ISMARA results: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.15

Motif logo

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Gene Symbol	Gene ID	Gene Info
Tfeb NCBI RGD Ensembl	ENSRNOG00000014666	transcription factor EB
Usf1 NCBI RGD Ensembl	ENSRNOG00000004255	upstream transcription factor 1
Srebf1 NCBI RGD Ensembl	ENSRNOG00000003463	sterol regulatory element binding transcription factor 1
Usf2 NCBI RGD Ensembl	ENSRNOG00000053725	upstream transcription factor 2, c-fos interacting
Bhlhe41 NCBI RGD Ensembl	ENSRNOG00000048961	basic helix-loop-helix family, member e41
Srebf2 NCBI RGD Ensembl	ENSRNOG00000007400	sterol regulatory element binding transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tfeb	rn6_v1_chr9_-_15214596_15214596	0.53	3.0e-24	Click!
Usf2	rn6_v1_chr1_-_89382463_89382463	0.37	1.2e-11	Click!
Usf1	rn6_v1_chr13_+_89797800_89797800	0.34	2.5e-10	Click!
Srebf2	rn6_v1_chr7_+_123381077_123381082	0.14	1.5e-02	Click!
Srebf1	rn6_v1_chr10_-_46593009_46593009	0.10	7.3e-02	Click!
Bhlhe41	rn6_v1_chr4_-_180234804_180234804	0.06	3.1e-01	Click!

Activity profile of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Sorted Z-values of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_161298962 Show fit	113.24	ENSRNOT00000066028	Ctsa NCBI RGD Ensembl Show fit	cathepsin A
chr10_+_84135116 Show fit	81.58	ENSRNOT00000031035	Hoxb7 NCBI RGD Ensembl Show fit	homeo box B7
chr3_-_161299024 Show fit	64.76	ENSRNOT00000021216	Neurl2 NCBI RGD Ensembl Show fit	neuralized E3 ubiquitin protein ligase 2
chr7_+_65616177 Show fit	59.56	ENSRNOT00000006566	Gns NCBI RGD Ensembl Show fit	glucosamine (N-acetyl)-6-sulfatase
chr5_-_164844586 Show fit	59.26	ENSRNOT00000011287	Clcn6 NCBI RGD Ensembl Show fit	chloride voltage-gated channel 6
chr7_+_63467216 Show fit	51.95	ENSRNOT00000064349	LOC100909505 NCBI RGD Ensembl Show fit	N-acetylglucosamine-6-sulfatase-like
chr1_+_48176106 Show fit	50.58	ENSRNOT00000021840	Igf2r NCBI RGD Ensembl Show fit	insulin-like growth factor 2 receptor
chr10_-_13536899 Show fit	49.83	ENSRNOT00000008537	Amdhd2 NCBI RGD Ensembl Show fit	amidohydrolase domain containing 2
chr10_+_56610051 Show fit	43.01	ENSRNOT00000024348	Dvl2 NCBI RGD Ensembl Show fit	dishevelled segment polarity protein 2
chrX_-_105417323 Show fit	40.88	ENSRNOT00000015494	Gla NCBI RGD Ensembl Show fit	galactosidase, alpha
chrX_+_134979646 Show fit	40.64	ENSRNOT00000006035	Sash3 NCBI RGD Ensembl Show fit	SAM and SH3 domain containing 3
chr16_-_81706664 Show fit	39.73	ENSRNOT00000026580	Lamp1 NCBI RGD Ensembl Show fit	lysosomal-associated membrane protein 1
chr9_-_82345262 Show fit	39.05	ENSRNOT00000024975	Cnppd1 NCBI RGD Ensembl Show fit	cyclin Pas1/PHO80 domain containing 1
chr14_-_84189266 Show fit	38.41	ENSRNOT00000005934	Tcn2 NCBI RGD Ensembl Show fit	transcobalamin 2
chr7_-_121058029 Show fit	37.92	ENSRNOT00000068033	Cbx6 NCBI RGD Ensembl Show fit	chromobox 6
chr13_+_70174936 Show fit	37.26	ENSRNOT00000064068 ENSRNOT00000079861 ENSRNOT00000092562	Arpc5 NCBI RGD Ensembl Show fit	actin related protein 2/3 complex, subunit 5
chr7_-_12741296 Show fit	37.23	ENSRNOT00000060648	Arhgap45 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 45
chr19_-_601469 Show fit	36.04	ENSRNOT00000016462	Pdp2 NCBI RGD Ensembl Show fit	pyruvate dehyrogenase phosphatase catalytic subunit 2
chr2_+_164747677 Show fit	35.58	ENSRNOT00000018489	Mfsd1 NCBI RGD Ensembl Show fit	major facilitator superfamily domain containing 1
chr1_+_166991474 Show fit	35.30	ENSRNOT00000027150	LOC100361543 NCBI RGD Ensembl Show fit	RhoA activator C11orf59-like
chr17_-_1879279 Show fit	30.03	ENSRNOT00000025462	Ctsl NCBI RGD Ensembl Show fit	cathepsin L
chr7_-_67116980 Show fit	29.85	ENSRNOT00000005798	Ppm1h NCBI RGD Ensembl Show fit	protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr13_-_70174565 Show fit	29.41	ENSRNOT00000067135	Rgl1 NCBI RGD Ensembl Show fit	ral guanine nucleotide dissociation stimulator,-like 1
chr5_+_90800082 Show fit	28.99	ENSRNOT00000093696 ENSRNOT00000093206	Kdm4c NCBI RGD Ensembl Show fit	lysine demethylase 4C
chr6_+_135724455 Show fit	28.91	ENSRNOT00000012469	Amn NCBI RGD Ensembl Show fit	amnion associated transmembrane protein
chr2_+_187697523 Show fit	28.57	ENSRNOT00000026153	Glmp NCBI RGD Ensembl Show fit	glycosylated lysosomal membrane protein
chr5_-_147784311 Show fit	28.13	ENSRNOT00000074172	Fam167b NCBI RGD Ensembl Show fit	family with sequence similarity 167, member B
chr2_+_188489362 Show fit	28.01	ENSRNOT00000027815	Clk2 NCBI RGD Ensembl Show fit	CDC-like kinase 2
chr1_-_101457126 Show fit	27.82	ENSRNOT00000087061 ENSRNOT00000028328	Bax NCBI RGD Ensembl Show fit	BCL2 associated X, apoptosis regulator
chr20_+_46250363 Show fit	27.23	ENSRNOT00000076522 ENSRNOT00000000334	Cd164 NCBI RGD Ensembl Show fit	CD164 molecule
chr1_+_103172987 Show fit	26.71	ENSRNOT00000018688	Tmem86a NCBI RGD Ensembl Show fit	transmembrane protein 86A
chr16_+_20426566 Show fit	26.53	ENSRNOT00000026225	Ifi30 NCBI RGD Ensembl Show fit	IFI30, lysosomal thiol reductase
chr19_-_38120578 Show fit	26.49	ENSRNOT00000026873	Esrp2 NCBI RGD Ensembl Show fit	epithelial splicing regulatory protein 2
chr12_+_2054680 Show fit	26.38	ENSRNOT00000001290	Mcoln1 NCBI RGD Ensembl Show fit	mucolipin 1
chr4_-_82271893 Show fit	26.29	ENSRNOT00000075005	Hoxa7 NCBI RGD Ensembl Show fit	homeobox A7
chr7_+_13062196 Show fit	26.15	ENSRNOT00000000193	Plpp2 NCBI RGD Ensembl Show fit	phospholipid phosphatase 2
chr3_+_61604672 Show fit	25.91	ENSRNOT00000080456	Hoxd11 NCBI RGD Ensembl Show fit	homeobox D11
chrX_-_54303729 Show fit	25.91	ENSRNOT00000087919 ENSRNOT00000064340 ENSRNOT00000051249 ENSRNOT00000087547	Gk NCBI RGD Ensembl Show fit	glycerol kinase
chr1_-_32140136 Show fit	25.83	ENSRNOT00000081339 ENSRNOT00000022635	Slc12a7 NCBI RGD Ensembl Show fit	solute carrier family 12 member 7
chr18_+_71395830 Show fit	25.50	ENSRNOT00000024831	Smad7 NCBI RGD Ensembl Show fit	SMAD family member 7
chr2_-_33841499 Show fit	25.27	ENSRNOT00000040533	Srek1 NCBI RGD Ensembl Show fit	splicing regulatory glutamic acid and lysine rich protein 1
chr5_-_79691258 Show fit	24.96	ENSRNOT00000072920	Tnfsf8 NCBI RGD Ensembl Show fit	tumor necrosis factor superfamily member 8
chr8_+_23014956 Show fit	24.89	ENSRNOT00000018009	Prkcsh NCBI RGD Ensembl Show fit	protein kinase C substrate 80K-H
chr6_+_26587443 Show fit	24.44	ENSRNOT00000034207	Mpv17 NCBI RGD Ensembl Show fit	MpV17 mitochondrial inner membrane protein
chrX_-_156399760 Show fit	24.40	ENSRNOT00000086921	Fam50a NCBI RGD Ensembl Show fit	family with sequence similarity 50, member A
chr4_-_140220487 Show fit	24.28	ENSRNOT00000009008	Sumf1 NCBI RGD Ensembl Show fit	sulfatase modifying factor 1
chr11_-_68197772 Show fit	24.16	ENSRNOT00000003060 ENSRNOT00000081875	Hspbap1 NCBI RGD Ensembl Show fit	Hspb associated protein 1
chr8_+_117117430 Show fit	24.15	ENSRNOT00000073247	Gpx1 NCBI RGD Ensembl Show fit	glutathione peroxidase 1
chr4_-_82186190 Show fit	24.10	ENSRNOT00000071729	LOC100911622 NCBI RGD Ensembl Show fit	homeobox protein Hox-A7-like
chr17_-_67904674 Show fit	23.70	ENSRNOT00000078532	Klf6 NCBI RGD Ensembl Show fit	Kruppel-like factor 6
chr3_+_61613774 Show fit	23.61	ENSRNOT00000002148	Hoxd10 NCBI RGD Ensembl Show fit	homeo box D10
chr6_-_55001464 Show fit	23.60	ENSRNOT00000006618	Ahr NCBI RGD Ensembl Show fit	aryl hydrocarbon receptor
chr15_+_46316741 Show fit	23.49	ENSRNOT00000014177	Ctsb NCBI RGD Ensembl Show fit	cathepsin B
chr14_+_63095720 Show fit	23.06	ENSRNOT00000006071	Ppargc1a NCBI RGD Ensembl Show fit	PPARG coactivator 1 alpha
chr19_-_55423052 Show fit	22.50	ENSRNOT00000019528 ENSRNOT00000079641	Galns NCBI RGD Ensembl Show fit	galactosamine (N-acetyl)-6-sulfatase
chr12_-_14175945 Show fit	22.41	ENSRNOT00000001469	Ap5z1 NCBI RGD Ensembl Show fit	adaptor-related protein complex 5, zeta 1 subunit
chr10_+_16970626 Show fit	22.03	ENSRNOT00000005383	Dusp1 NCBI RGD Ensembl Show fit	dual specificity phosphatase 1
chr1_-_22625204 Show fit	21.99	ENSRNOT00000021694	Vnn1 NCBI RGD Ensembl Show fit	vanin 1
chr3_+_28627084 Show fit	21.59	ENSRNOT00000049884	Arhgap15 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 15
chr10_-_56850085 Show fit	21.53	ENSRNOT00000025767	Rnasek NCBI RGD Ensembl Show fit	ribonuclease K
chr4_+_78694447 Show fit	21.32	ENSRNOT00000011945	Gpnmb NCBI RGD Ensembl Show fit	glycoprotein nmb
chr9_-_37144015 Show fit	21.26	ENSRNOT00000015638	Phf3 NCBI RGD Ensembl Show fit	PHD finger protein 3
chr10_+_106785077 Show fit	21.21	ENSRNOT00000075047	Tmc8 NCBI RGD Ensembl Show fit	transmembrane channel-like 8
chrX_-_10413984 Show fit	21.20	ENSRNOT00000039551 ENSRNOT00000091448	Ddx3x NCBI RGD Ensembl Show fit	DEAD-box helicase 3, X-linked
chr11_+_73936750 Show fit	21.07	ENSRNOT00000002350	Atp13a3 NCBI RGD Ensembl Show fit	ATPase 13A3
chr8_-_94922017 Show fit	20.78	ENSRNOT00000083934	Cep162 NCBI RGD Ensembl Show fit	centrosomal protein 162
chr5_-_164898420 Show fit	20.65	ENSRNOT00000011747	Agtrap NCBI RGD Ensembl Show fit	angiotensin II receptor-associated protein
chr8_+_50310405 Show fit	20.59	ENSRNOT00000073507	Sik3 NCBI RGD Ensembl Show fit	SIK family kinase 3
chr19_-_55257876 Show fit	20.46	ENSRNOT00000017564	Cyba NCBI RGD Ensembl Show fit	cytochrome b-245 alpha chain
chr5_+_78120607 Show fit	20.44	ENSRNOT00000019379	Slc31a2 NCBI RGD Ensembl Show fit	solute carrier family 31 member 2
chr17_+_10463303 Show fit	20.40	ENSRNOT00000060822	Rnf44 NCBI RGD Ensembl Show fit	ring finger protein 44
chr1_-_215553451 Show fit	20.22	ENSRNOT00000027407	Ctsd NCBI RGD Ensembl Show fit	cathepsin D
chr12_-_48365784 Show fit	20.21	ENSRNOT00000077317	Dao NCBI RGD Ensembl Show fit	D-amino-acid oxidase
chr1_-_260254600 Show fit	20.21	ENSRNOT00000019014	Blnk NCBI RGD Ensembl Show fit	B-cell linker
chr10_+_84167331 Show fit	20.21	ENSRNOT00000010965	Hoxb4 NCBI RGD Ensembl Show fit	homeo box B4
chr3_-_2573387 Show fit	20.09	ENSRNOT00000017271	Dpp7 NCBI RGD Ensembl Show fit	dipeptidylpeptidase 7
chr8_-_23146689 Show fit	19.96	ENSRNOT00000092200	Acp5 NCBI RGD Ensembl Show fit	acid phosphatase 5, tartrate resistant
chr19_-_37525762 Show fit	19.70	ENSRNOT00000023606	Atp6v0d1 NCBI RGD Ensembl Show fit	ATPase H+ transporting V0 subunit D1
chr10_+_47961056 Show fit	19.64	ENSRNOT00000027312	Fam83g NCBI RGD Ensembl Show fit	family with sequence similarity 83, member G
chr19_+_9622611 Show fit	19.53	ENSRNOT00000061498	Slc38a7 NCBI RGD Ensembl Show fit	solute carrier family 38, member 7
chr20_-_5533448 Show fit	19.41	ENSRNOT00000000568	Cuta NCBI RGD Ensembl Show fit	cutA divalent cation tolerance homolog
chr4_-_82194927 Show fit	19.27	ENSRNOT00000072302	LOC103692128 NCBI RGD Ensembl Show fit	homeobox protein Hox-A9
chr7_+_2737765 Show fit	18.99	ENSRNOT00000004895	Cnpy2 NCBI RGD Ensembl Show fit	canopy FGF signaling regulator 2
chr10_-_14215957 Show fit	18.73	ENSRNOT00000019767	Fahd1 NCBI RGD Ensembl Show fit	fumarylacetoacetate hydrolase domain containing 1
chr2_-_259898525 Show fit	18.71	ENSRNOT00000082253	St6galnac3 NCBI RGD Ensembl Show fit	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr3_+_72238981 Show fit	18.68	ENSRNOT00000011006	Slc43a1 NCBI RGD Ensembl Show fit	solute carrier family 43 member 1
chr1_+_154377447 Show fit	18.67	ENSRNOT00000084268 ENSRNOT00000092086 ENSRNOT00000091470 ENSRNOT00000025415	Picalm NCBI RGD Ensembl Show fit	phosphatidylinositol binding clathrin assembly protein
chr6_-_3794489 Show fit	18.54	ENSRNOT00000087891 ENSRNOT00000011000 ENSRNOT00000084499	Thumpd2 NCBI RGD Ensembl Show fit	THUMP domain containing 2
chr12_+_23544287 Show fit	18.53	ENSRNOT00000001938	Orai2 NCBI RGD Ensembl Show fit	ORAI calcium release-activated calcium modulator 2
chr10_+_90376933 Show fit	18.46	ENSRNOT00000028557	Grn NCBI RGD Ensembl Show fit	granulin precursor
chr1_-_73660593 Show fit	18.43	ENSRNOT00000038802	Lilra5 NCBI RGD Ensembl Show fit	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
chr1_-_282170017 Show fit	18.27	ENSRNOT00000066947	Eif3a NCBI RGD Ensembl Show fit	eukaryotic translation initiation factor 3, subunit A
chr6_+_86785771 Show fit	18.07	ENSRNOT00000066702	Prpf39 NCBI RGD Ensembl Show fit	pre-mRNA processing factor 39
chr1_-_170594168 Show fit	18.07	ENSRNOT00000026280	Tpp1 NCBI RGD Ensembl Show fit	tripeptidyl peptidase 1
chr10_-_4644570 Show fit	18.04	ENSRNOT00000088279	Snn NCBI RGD Ensembl Show fit	stannin
chr17_+_9837402 Show fit	18.04	ENSRNOT00000076436	Rab24 NCBI RGD Ensembl Show fit	RAB24, member RAS oncogene family
chr1_+_144601410 Show fit	17.97	ENSRNOT00000047408	Efl1 NCBI RGD Ensembl Show fit	elongation factor like GTPase 1
chr1_-_100537377 Show fit	17.94	ENSRNOT00000026599	Spib NCBI RGD Ensembl Show fit	Spi-B transcription factor
chr4_-_120840111 Show fit	17.93	ENSRNOT00000022231	Mcm2 NCBI RGD Ensembl Show fit	minichromosome maintenance complex component 2
chr12_+_22451596 Show fit	17.81	ENSRNOT00000072838	Trip6 NCBI RGD Ensembl Show fit	thyroid hormone receptor interactor 6
chr2_+_93792601 Show fit	17.58	ENSRNOT00000014701 ENSRNOT00000077311	Fabp4 NCBI RGD Ensembl Show fit	fatty acid binding protein 4
chr5_-_138470096 Show fit	17.50	ENSRNOT00000011392	Ppcs NCBI RGD Ensembl Show fit	phosphopantothenoylcysteine synthetase
chr1_+_154377247 Show fit	17.34	ENSRNOT00000092945	Picalm NCBI RGD Ensembl Show fit	phosphatidylinositol binding clathrin assembly protein
chr1_-_80544825 Show fit	17.13	ENSRNOT00000057802 ENSRNOT00000040060 ENSRNOT00000067049 ENSRNOT00000052387 ENSRNOT00000073352	Relb NCBI RGD Ensembl Show fit	RELB proto-oncogene, NF-kB subunit
chr3_+_113415774 Show fit	17.11	ENSRNOT00000056151	Serf2 NCBI RGD Ensembl Show fit	small EDRK-rich factor 2
chr10_+_90377103 Show fit	17.09	ENSRNOT00000040472	Grn NCBI RGD Ensembl Show fit	granulin precursor
chr8_-_104995725 Show fit	17.05	ENSRNOT00000037120	Slc25a36 NCBI RGD Ensembl Show fit	solute carrier family 25 member 36
chr19_+_26022849 Show fit	17.04	ENSRNOT00000014887	Dnase2 NCBI RGD Ensembl Show fit	deoxyribonuclease 2, lysosomal
chr1_-_222495382 Show fit	17.02	ENSRNOT00000028759	Naa40 NCBI RGD Ensembl Show fit	N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr9_-_61690956 Show fit	16.81	ENSRNOT00000066589	Hspd1 NCBI RGD Ensembl Show fit	heat shock protein family D member 1
chr12_+_16340922 Show fit	16.71	ENSRNOT00000001696	Snx8 NCBI RGD Ensembl Show fit	sorting nexin 8
chrX_+_16170576 Show fit	16.67	ENSRNOT00000003895	Clcn5 NCBI RGD Ensembl Show fit	chloride voltage-gated channel 5
chr2_-_104830898 Show fit	16.65	ENSRNOT00000050440	Hps3 NCBI RGD Ensembl Show fit	Hermansky-Pudlak syndrome 3
chr1_-_219450451 Show fit	16.50	ENSRNOT00000025317	Rad9a NCBI RGD Ensembl Show fit	RAD9 checkpoint clamp component A
chr10_-_62287189 Show fit	16.41	ENSRNOT00000004365	Wdr81 NCBI RGD Ensembl Show fit	WD repeat domain 81
chr2_+_188516582 Show fit	16.34	ENSRNOT00000074727	Gba NCBI RGD Ensembl Show fit	glucosylceramidase beta
chr2_+_266315036 Show fit	16.20	ENSRNOT00000055245	Wls NCBI RGD Ensembl Show fit	wntless Wnt ligand secretion mediator
chr5_-_50362344 Show fit	16.19	ENSRNOT00000035808	Zfp292 NCBI RGD Ensembl Show fit	zinc finger protein 292
chr2_-_178616719 Show fit	15.96	ENSRNOT00000078610	Tmem144 NCBI RGD Ensembl Show fit	transmembrane protein 144
chr17_-_9837293 Show fit	15.94	ENSRNOT00000091320 ENSRNOT00000022134	Prelid1 NCBI RGD Ensembl Show fit	PRELI domain containing 1
chr11_-_38457373 Show fit	15.87	ENSRNOT00000041177	Zfp295 NCBI RGD Ensembl Show fit	zinc finger protein 295
chr8_-_121973125 Show fit	15.85	ENSRNOT00000012114	Pdcd6ip NCBI RGD Ensembl Show fit	programmed cell death 6 interacting protein
chr2_-_52282548 Show fit	15.84	ENSRNOT00000033627	Nnt NCBI RGD Ensembl Show fit	nicotinamide nucleotide transhydrogenase
chr20_-_5533600 Show fit	15.83	ENSRNOT00000072319	Cuta NCBI RGD Ensembl Show fit	cutA divalent cation tolerance homolog
chr5_+_145138697 Show fit	15.69	ENSRNOT00000019135	Zmym6 NCBI RGD Ensembl Show fit	zinc finger MYM-type containing 6
chr10_+_88997399 Show fit	15.61	ENSRNOT00000027116	Mlx NCBI RGD Ensembl Show fit	MLX, MAX dimerization protein
chr1_-_164101578 Show fit	15.60	ENSRNOT00000022176	Uvrag NCBI RGD Ensembl Show fit	UV radiation resistance associated
chr5_-_166259069 Show fit	15.57	ENSRNOT00000055572	Ube4b NCBI RGD Ensembl Show fit	ubiquitination factor E4B
chr9_-_88086488 Show fit	15.55	ENSRNOT00000019579	Irs1 NCBI RGD Ensembl Show fit	insulin receptor substrate 1
chr3_-_175709465 Show fit	15.53	ENSRNOT00000089971	Gata5 NCBI RGD Ensembl Show fit	GATA binding protein 5
chr10_+_29067102 Show fit	15.44	ENSRNOT00000005161	C1qtnf2 NCBI RGD Ensembl Show fit	C1q and tumor necrosis factor related protein 2
chr15_-_43667029 Show fit	15.35	ENSRNOT00000014798	Bnip3l NCBI RGD Ensembl Show fit	BCL2/adenovirus E1B interacting protein 3-like
chr8_-_115621394 Show fit	15.32	ENSRNOT00000018995	Rbm15b NCBI RGD Ensembl Show fit	RNA binding motif protein 15B
chr3_-_94808861 Show fit	15.20	ENSRNOT00000038464	Prrg4 NCBI RGD Ensembl Show fit	proline rich and Gla domain 4
chr1_-_228194977 Show fit	15.15	ENSRNOT00000028535	Stx3 NCBI RGD Ensembl Show fit	syntaxin 3
chr15_-_32780603 Show fit	15.13	ENSRNOT00000046980	Trdv5 NCBI RGD Ensembl Show fit	T cell receptor delta variable 5
chr2_-_104958034 Show fit	15.12	ENSRNOT00000080699	Gyg1 NCBI RGD Ensembl Show fit	glycogenin 1
chr2_+_190007216 Show fit	15.12	ENSRNOT00000015612	S100a6 NCBI RGD Ensembl Show fit	S100 calcium binding protein A6
chr10_+_76343847 Show fit	15.04	ENSRNOT00000055674	Trim25 NCBI RGD Ensembl Show fit	tripartite motif-containing 25
chr13_+_109713489 Show fit	15.03	ENSRNOT00000004962	Batf3 NCBI RGD Ensembl Show fit	basic leucine zipper ATF-like transcription factor 3
chrX_+_33599671 Show fit	14.99	ENSRNOT00000006843	Txlng NCBI RGD Ensembl Show fit	taxilin gamma
chr19_-_24831500 Show fit	14.95	ENSRNOT00000005770	Pkn1 NCBI RGD Ensembl Show fit	protein kinase N1
chr7_+_3332788 Show fit	14.86	ENSRNOT00000010180	Cd63 NCBI RGD Ensembl Show fit	Cd63 molecule
chr20_-_11737050 Show fit	14.72	ENSRNOT00000001637	Sumo3 NCBI RGD Ensembl Show fit	small ubiquitin-like modifier 3
chr4_-_82215022 Show fit	14.70	ENSRNOT00000010256	Hoxa11 NCBI RGD Ensembl Show fit	homeobox A11
chr6_-_26820959 Show fit	14.58	ENSRNOT00000043572	Khk NCBI RGD Ensembl Show fit	ketohexokinase
chrX_-_123474154 Show fit	14.56	ENSRNOT00000092415 ENSRNOT00000092455	RGD1564541 NCBI RGD Ensembl Show fit	similar to hypothetical protein FLJ22965
chr11_+_80255790 Show fit	14.41	ENSRNOT00000002522	Bcl6 NCBI RGD Ensembl Show fit	B-cell CLL/lymphoma 6
chr2_-_53827175 Show fit	14.40	ENSRNOT00000078158	RGD1305938 NCBI RGD Ensembl Show fit	similar to expressed sequence AW549877
chr7_+_144628120 Show fit	14.37	ENSRNOT00000022247	Hoxc5 NCBI RGD Ensembl Show fit	homeo box C5
chr2_+_122690278 Show fit	14.28	ENSRNOT00000086831	AABR07010085.1 NCBI RGD Ensembl Show fit
chr10_-_109811323 Show fit	14.06	ENSRNOT00000054970	Mafg NCBI RGD Ensembl Show fit	MAF bZIP transcription factor G
chr5_-_171648327 Show fit	14.06	ENSRNOT00000082847	Arhgef16 NCBI RGD Ensembl Show fit	Rho guanine nucleotide exchange factor 16
chr1_-_101123402 Show fit	13.94	ENSRNOT00000027976	Rpl13a NCBI RGD Ensembl Show fit
chr1_-_102849430 Show fit	13.80	ENSRNOT00000086856	Saa4 NCBI RGD Ensembl Show fit	serum amyloid A4
chr2_-_195423787 Show fit	13.80	ENSRNOT00000071603	LOC103689947 NCBI RGD Ensembl Show fit	selenium-binding protein 1
chr3_+_62481323 Show fit	13.78	ENSRNOT00000078872	Hnrnpa3 NCBI RGD Ensembl Show fit	heterogeneous nuclear ribonucleoprotein A3
chr12_+_47590154 Show fit	13.77	ENSRNOT00000045946	Git2 NCBI RGD Ensembl Show fit	GIT ArfGAP 2
chr10_-_82326771 Show fit	13.75	ENSRNOT00000004673	Acsf2 NCBI RGD Ensembl Show fit	acyl-CoA synthetase family member 2
chr8_+_77107536 Show fit	13.72	ENSRNOT00000083255	Adam10 NCBI RGD Ensembl Show fit	ADAM metallopeptidase domain 10
chr18_+_48132414 Show fit	13.68	ENSRNOT00000050631	Snx2 NCBI RGD Ensembl Show fit	sorting nexin 2
chr2_-_196113149 Show fit	13.54	ENSRNOT00000088465	Selenbp1 NCBI RGD Ensembl Show fit	selenium binding protein 1
chr8_+_81863619 Show fit	13.49	ENSRNOT00000080608	Fam214a NCBI RGD Ensembl Show fit	family with sequence similarity 214, member A
chr5_-_160352927 Show fit	13.38	ENSRNOT00000017247	Dnajc16 NCBI RGD Ensembl Show fit	DnaJ heat shock protein family (Hsp40) member C16
chr7_-_12673659 Show fit	13.29	ENSRNOT00000091650 ENSRNOT00000041277 ENSRNOT00000044865	Ptbp1 NCBI RGD Ensembl Show fit	polypyrimidine tract binding protein 1
chr3_+_155297566 Show fit	13.28	ENSRNOT00000021435 ENSRNOT00000084866	Dhx35 NCBI RGD Ensembl Show fit	DEAH-box helicase 35
chr5_-_159577134 Show fit	13.25	ENSRNOT00000011114	Crocc NCBI RGD Ensembl Show fit	ciliary rootlet coiled-coil, rootletin
chr4_+_82214342 Show fit	13.23	ENSRNOT00000066360	Hoxa11-as NCBI RGD Ensembl Show fit	homeobox A11, opposite strand
chr5_-_171648563 Show fit	13.21	ENSRNOT00000072786	Arhgef16 NCBI RGD Ensembl Show fit	Rho guanine nucleotide exchange factor 16
chr1_-_13175876 Show fit	13.13	ENSRNOT00000084870	Abracl NCBI RGD Ensembl Show fit	ABRA C-terminal like
chr9_+_16647598 Show fit	13.02	ENSRNOT00000087413	Klc4 NCBI RGD Ensembl Show fit	kinesin light chain 4
chr4_+_82300778 Show fit	12.94	ENSRNOT00000075254	Hoxa11-as NCBI RGD Ensembl Show fit	homeobox A11, opposite strand
chr7_+_141249044 Show fit	12.83	ENSRNOT00000084911	Aqp5 NCBI RGD Ensembl Show fit	aquaporin 5
chr7_-_27213651 Show fit	12.79	ENSRNOT00000077041 ENSRNOT00000076468	Tdg NCBI RGD Ensembl Show fit	thymine-DNA glycosylase
chr13_+_35554964 Show fit	12.73	ENSRNOT00000072632	Tmem185b NCBI RGD Ensembl Show fit	transmembrane protein 185B
chr4_+_122365093 Show fit	12.67	ENSRNOT00000024011	Klf15 NCBI RGD Ensembl Show fit	Kruppel-like factor 15
chr16_-_60427474 Show fit	12.66	ENSRNOT00000051720	Ppp1r3b NCBI RGD Ensembl Show fit	protein phosphatase 1, regulatory subunit 3B
chr19_+_14508616 Show fit	12.50	ENSRNOT00000019192	Hmox1 NCBI RGD Ensembl Show fit	heme oxygenase 1
chr10_-_74298599 Show fit	12.45	ENSRNOT00000007379	Ypel2 NCBI RGD Ensembl Show fit	yippee-like 2
chr2_+_40000313 Show fit	12.45	ENSRNOT00000014270	Depdc1b NCBI RGD Ensembl Show fit	DEP domain containing 1B
chr18_-_24397551 Show fit	12.42	ENSRNOT00000023032	Slc25a46 NCBI RGD Ensembl Show fit	solute carrier family 25, member 46
chr5_+_150725654 Show fit	12.42	ENSRNOT00000089852 ENSRNOT00000017740	Dnajc8 NCBI RGD Ensembl Show fit	DnaJ heat shock protein family (Hsp40) member C8
chr11_+_27364916 Show fit	12.35	ENSRNOT00000002151	Bach1 NCBI RGD Ensembl Show fit	BTB domain and CNC homolog 1
chr8_+_70994563 Show fit	12.30	ENSRNOT00000051504 ENSRNOT00000077163	Spg21 NCBI RGD Ensembl Show fit	spastic paraplegia 21 homolog (human)
chr10_-_35927268 Show fit	12.29	ENSRNOT00000004740	Rufy1 NCBI RGD Ensembl Show fit	RUN and FYVE domain containing 1
chrX_-_4945944 Show fit	12.16	ENSRNOT00000077238	Kdm6a NCBI RGD Ensembl Show fit	lysine demethylase 6A
chr14_-_2056762 Show fit	12.14	ENSRNOT00000000048	Idua NCBI RGD Ensembl Show fit	iduronidase, alpha-L-
chr16_+_2278701 Show fit	12.13	ENSRNOT00000016233	Dennd6a NCBI RGD Ensembl Show fit	DENN domain containing 6A
chrX_+_106823491 Show fit	12.13	ENSRNOT00000045997	Bex3 NCBI RGD Ensembl Show fit	brain expressed X-linked 3
chr7_+_41114697 Show fit	12.06	ENSRNOT00000041354	Atp2b1 NCBI RGD Ensembl Show fit	ATPase plasma membrane Ca2+ transporting 1
chr10_-_76263866 Show fit	11.97	ENSRNOT00000003219	Scpep1 NCBI RGD Ensembl Show fit	serine carboxypeptidase 1
chr4_-_82300503 Show fit	11.94	ENSRNOT00000071568	Hoxa11 NCBI RGD Ensembl Show fit	homeobox A11
chr6_-_102472926 Show fit	11.88	ENSRNOT00000079351	Zfyve26 NCBI RGD Ensembl Show fit	zinc finger FYVE-type containing 26
chr1_+_171820423 Show fit	11.80	ENSRNOT00000047831	Ppfibp2 NCBI RGD Ensembl Show fit	PPFIA binding protein 2
chr7_-_140291620 Show fit	11.80	ENSRNOT00000088323	Adcy6 NCBI RGD Ensembl Show fit	adenylate cyclase 6
chr9_-_41337498 Show fit	11.78	ENSRNOT00000039480	Fam168b NCBI RGD Ensembl Show fit	family with sequence similarity 168, member B
chr15_-_60766579 Show fit	11.67	ENSRNOT00000079978	Akap11 NCBI RGD Ensembl Show fit	A-kinase anchoring protein 11
chrX_+_77076106 Show fit	11.51	ENSRNOT00000091527 ENSRNOT00000089381	Atp7a NCBI RGD Ensembl Show fit	ATPase copper transporting alpha
chr4_+_99937558 Show fit	11.50	ENSRNOT00000050249	St3gal5 NCBI RGD Ensembl Show fit	ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr2_-_236395067 Show fit	11.48	ENSRNOT00000014658	Hadh NCBI RGD Ensembl Show fit	hydroxyacyl-CoA dehydrogenase

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
18.9	113.2	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)
14.9	59.6	GO:0042339	keratan sulfate metabolic process(GO:0042339)
13.5	67.3	GO:0015889	cobalamin transport(GO:0015889)
13.2	39.7	GO:0043323	positive regulation of natural killer cell degranulation(GO:0043323)
12.8	51.4	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
12.0	36.0	GO:1902962	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
9.3	9.3	GO:1904586	response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586)
9.3	27.8	GO:0097296	regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
8.6	25.9	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
8.0	24.1	GO:0009609	response to symbiotic bacterium(GO:0009609)
8.0	64.0	GO:0046477	glycosylceramide catabolic process(GO:0046477)
7.9	23.6	GO:1902544	regulation of DNA N-glycosylase activity(GO:1902544)
7.7	23.1	GO:1904638	cellular response to nitrite(GO:0071250) response to nitrite(GO:0080033) response to resveratrol(GO:1904638) regulation of progesterone biosynthetic process(GO:2000182)
7.5	37.5	GO:0009758	carbohydrate utilization(GO:0009758)
7.2	43.0	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
6.8	20.5	GO:1904844	response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
6.8	40.9	GO:0032439	endosome localization(GO:0032439)
6.8	20.3	GO:0042412	taurine biosynthetic process(GO:0042412)
6.7	20.2	GO:0046416	D-amino acid metabolic process(GO:0046416)
6.7	26.9	GO:0032763	regulation of mast cell cytokine production(GO:0032763)
6.5	19.5	GO:0089709	histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
6.3	19.0	GO:0045716	positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
6.1	18.2	GO:0043311	positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
5.9	17.8	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
5.9	35.6	GO:0001835	blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
5.9	23.6	GO:0040009	regulation of growth rate(GO:0040009)
5.7	17.0	GO:0061357	positive regulation of Wnt protein secretion(GO:0061357)
5.6	16.8	GO:0002840	T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840)
5.6	39.2	GO:0042256	mature ribosome assembly(GO:0042256)
5.5	27.4	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
5.3	37.2	GO:0048102	autophagic cell death(GO:0048102)
5.3	15.8	GO:0044837	assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
5.3	15.8	GO:0060764	cell-cell signaling involved in mammary gland development(GO:0060764)
5.2	15.5	GO:1901420	negative regulation of vitamin D receptor signaling pathway(GO:0070563) negative regulation of response to alcohol(GO:1901420)
4.7	60.9	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272)
4.7	4.7	GO:0061034	olfactory bulb mitral cell layer development(GO:0061034)
4.6	4.6	GO:0002397	MHC class I protein complex assembly(GO:0002397)
4.6	13.7	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
4.6	18.3	GO:0002188	translation reinitiation(GO:0002188)
4.4	13.3	GO:0032053	ciliary basal body organization(GO:0032053) positive regulation of protein localization to cilium(GO:1903566)
4.1	12.4	GO:0090149	mitochondrial membrane fission(GO:0090149)
4.1	37.3	GO:0021769	orbitofrontal cortex development(GO:0021769)
4.1	8.2	GO:0030043	actin filament fragmentation(GO:0030043)
4.1	16.4	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
4.1	4.1	GO:0016240	autophagosome docking(GO:0016240)
4.1	32.6	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
4.0	12.1	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
4.0	20.2	GO:0048539	bone marrow development(GO:0048539)
4.0	28.2	GO:0045656	negative regulation of monocyte differentiation(GO:0045656)
3.9	15.6	GO:0097680	double-strand break repair via classical nonhomologous end joining(GO:0097680)
3.9	15.6	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
3.8	11.4	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
3.8	11.3	GO:0042822	pyridoxal phosphate metabolic process(GO:0042822)
3.6	25.5	GO:2000317	negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
3.5	10.4	GO:0003430	growth plate cartilage chondrocyte growth(GO:0003430)
3.4	23.7	GO:0071409	cellular response to cycloheximide(GO:0071409)
3.3	9.9	GO:0006552	leucine catabolic process(GO:0006552)
3.3	22.8	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
3.2	15.9	GO:1901857	positive regulation of cellular respiration(GO:1901857)
3.2	9.5	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
3.1	9.4	GO:0031296	B cell costimulation(GO:0031296)
3.1	81.6	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
3.1	12.5	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
3.1	9.4	GO:0035964	COPI-coated vesicle budding(GO:0035964)
3.1	18.4	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
3.0	14.9	GO:0002634	regulation of germinal center formation(GO:0002634)
3.0	5.9	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
3.0	11.8	GO:1900224	zygotic specification of dorsal/ventral axis(GO:0007352) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
2.9	40.6	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
2.9	11.5	GO:1904959	negative regulation of iron ion transmembrane transport(GO:0034760) elastin biosynthetic process(GO:0051542) regulation of cytochrome-c oxidase activity(GO:1904959)
2.8	11.3	GO:0090204	protein localization to nuclear pore(GO:0090204)
2.7	8.1	GO:0006117	acetaldehyde metabolic process(GO:0006117)
2.7	32.4	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
2.7	13.3	GO:0070094	positive regulation of glucagon secretion(GO:0070094)
2.5	2.5	GO:1902304	positive regulation of potassium ion export(GO:1902304)
2.5	9.9	GO:0050787	detoxification of mercury ion(GO:0050787)
2.4	12.2	GO:0071557	histone H3-K27 demethylation(GO:0071557)
2.4	9.7	GO:0046951	ketone body biosynthetic process(GO:0046951)
2.4	12.1	GO:0030205	dermatan sulfate metabolic process(GO:0030205)
2.4	4.8	GO:0009608	response to symbiont(GO:0009608)
2.4	7.2	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
2.4	4.7	GO:1904587	response to glycoprotein(GO:1904587)
2.4	7.1	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
2.3	7.0	GO:0021997	neural plate axis specification(GO:0021997)
2.3	30.4	GO:0034498	early endosome to Golgi transport(GO:0034498)
2.3	9.3	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
2.3	4.6	GO:1903463	regulation of mitotic cell cycle DNA replication(GO:1903463)
2.3	16.0	GO:0043622	cortical microtubule organization(GO:0043622)
2.3	11.4	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
2.3	6.8	GO:0009227	nucleotide-sugar catabolic process(GO:0009227)
2.3	18.1	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
2.2	6.7	GO:0044565	dendritic cell proliferation(GO:0044565)
2.2	6.7	GO:0032258	CVT pathway(GO:0032258)
2.2	6.5	GO:0071163	DNA replication preinitiation complex assembly(GO:0071163)
2.2	15.2	GO:0098881	exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
2.1	8.6	GO:0051142	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
2.1	6.4	GO:1903070	negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
2.1	4.2	GO:0071288	cellular response to mercury ion(GO:0071288)
2.1	6.2	GO:0030327	prenylated protein catabolic process(GO:0030327)
2.1	25.0	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
2.0	4.1	GO:0035973	aggrephagy(GO:0035973)
2.0	46.0	GO:0002115	store-operated calcium entry(GO:0002115)
2.0	2.0	GO:0070237	positive regulation of activation-induced cell death of T cells(GO:0070237)
2.0	11.8	GO:0072658	maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660)
2.0	7.9	GO:0006957	complement activation, alternative pathway(GO:0006957)
1.9	5.7	GO:0006478	peptidyl-tyrosine sulfation(GO:0006478)
1.9	7.6	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
1.9	5.7	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
1.9	16.9	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
1.9	24.4	GO:0032836	glomerular basement membrane development(GO:0032836)
1.9	20.6	GO:0038166	angiotensin-activated signaling pathway(GO:0038166)
1.9	3.7	GO:0002086	diaphragm contraction(GO:0002086)
1.9	14.9	GO:2000680	regulation of rubidium ion transport(GO:2000680)
1.9	5.6	GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
1.8	12.9	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
1.8	12.8	GO:0015670	carbon dioxide transport(GO:0015670)
1.8	7.3	GO:0015811	L-cystine transport(GO:0015811)
1.8	16.4	GO:0035434	copper ion transmembrane transport(GO:0035434)
1.8	21.5	GO:0071493	cellular response to UV-B(GO:0071493)
1.8	19.7	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
1.8	1.8	GO:0033364	mast cell secretory granule organization(GO:0033364)
1.8	5.4	GO:0046604	positive regulation of mitotic centrosome separation(GO:0046604)
1.8	5.3	GO:0071529	cementum mineralization(GO:0071529)
1.8	10.6	GO:0015860	purine nucleoside transmembrane transport(GO:0015860)
1.8	21.1	GO:0038094	Fc-gamma receptor signaling pathway(GO:0038094)
1.7	10.5	GO:0015074	DNA integration(GO:0015074)
1.7	7.0	GO:0044725	chromatin reprogramming in the zygote(GO:0044725)
1.7	6.9	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
1.7	8.6	GO:0002003	angiotensin maturation(GO:0002003)
1.7	15.4	GO:0046479	glycosphingolipid catabolic process(GO:0046479)
1.7	8.5	GO:0034059	response to anoxia(GO:0034059)
1.7	22.0	GO:0090266	regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
1.7	22.0	GO:2000400	positive regulation of T cell differentiation in thymus(GO:0033089) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176) positive regulation of thymocyte aggregation(GO:2000400)
1.7	15.2	GO:0033299	secretion of lysosomal enzymes(GO:0033299)
1.7	5.0	GO:0032474	otolith morphogenesis(GO:0032474)
1.7	15.1	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
1.7	5.0	GO:0046833	positive regulation of RNA export from nucleus(GO:0046833)
1.7	13.3	GO:0075522	IRES-dependent viral translational initiation(GO:0075522)
1.6	31.3	GO:0006491	N-glycan processing(GO:0006491)
1.6	8.2	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
1.6	4.9	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
1.6	11.5	GO:1901098	positive regulation of autophagosome maturation(GO:1901098)
1.6	54.0	GO:0060441	epithelial tube branching involved in lung morphogenesis(GO:0060441)
1.6	35.8	GO:0097503	sialylation(GO:0097503)
1.6	11.4	GO:0072717	cellular response to actinomycin D(GO:0072717)
1.6	3.2	GO:1903936	cellular response to sodium arsenite(GO:1903936)
1.6	69.4	GO:1903959	regulation of anion transmembrane transport(GO:1903959)
1.6	7.9	GO:1904401	cellular response to Thyroid stimulating hormone(GO:1904401)
1.6	6.2	GO:0035494	SNARE complex disassembly(GO:0035494)
1.5	7.6	GO:0015808	L-alanine transport(GO:0015808)
1.5	7.5	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
1.5	6.0	GO:0048549	protein depalmitoylation(GO:0002084) positive regulation of pinocytosis(GO:0048549)
1.5	4.5	GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
1.5	33.8	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
1.5	26.4	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
1.5	8.7	GO:0071386	cellular response to corticosterone stimulus(GO:0071386)
1.4	7.2	GO:0097332	response to antipsychotic drug(GO:0097332)
1.4	4.3	GO:1990737	negative regulation of translational initiation in response to stress(GO:0032057) response to manganese-induced endoplasmic reticulum stress(GO:1990737)
1.4	19.9	GO:0032460	negative regulation of protein oligomerization(GO:0032460)
1.4	5.4	GO:0060857	establishment of glial blood-brain barrier(GO:0060857)
1.3	2.7	GO:1903691	positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
1.3	9.3	GO:2000074	regulation of type B pancreatic cell development(GO:2000074)
1.3	6.6	GO:0007042	lysosomal lumen acidification(GO:0007042)
1.3	17.0	GO:0006309	apoptotic DNA fragmentation(GO:0006309)
1.3	5.2	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
1.3	3.9	GO:1904431	positive regulation of t-circle formation(GO:1904431)
1.3	15.4	GO:0046321	positive regulation of fatty acid oxidation(GO:0046321)
1.3	7.6	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
1.3	2.5	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
1.3	8.8	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
1.3	2.5	GO:0002447	eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
1.2	2.5	GO:0042539	hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
1.2	6.2	GO:0006685	sphingomyelin catabolic process(GO:0006685)
1.2	1.2	GO:0097167	circadian regulation of translation(GO:0097167)
1.2	14.6	GO:0009744	response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
1.2	21.6	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
1.2	4.7	GO:0033668	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
1.2	10.6	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
1.2	9.4	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
1.2	19.8	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
1.2	4.7	GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
1.2	10.4	GO:0045759	cannabinoid signaling pathway(GO:0038171) negative regulation of action potential(GO:0045759)
1.1	1.1	GO:2000259	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
1.1	3.4	GO:1903542	negative regulation of exosomal secretion(GO:1903542)
1.1	10.1	GO:0018344	protein geranylgeranylation(GO:0018344)
1.1	3.3	GO:1900220	semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
1.1	5.4	GO:1903223	cellular response to temperature stimulus(GO:0071502) positive regulation of oxidative stress-induced neuron death(GO:1903223)
1.1	5.4	GO:1904528	positive regulation of microtubule binding(GO:1904528)
1.1	7.6	GO:0016259	selenocysteine metabolic process(GO:0016259)
1.1	4.2	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)
1.1	3.2	GO:0033123	positive regulation of purine nucleotide catabolic process(GO:0033123)
1.0	6.3	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.0	17.6	GO:0050872	white fat cell differentiation(GO:0050872)
1.0	25.7	GO:0097352	autophagosome maturation(GO:0097352)
1.0	11.2	GO:0044804	nucleophagy(GO:0044804)
1.0	29.9	GO:0009303	rRNA transcription(GO:0009303)
1.0	4.9	GO:0006868	glutamine transport(GO:0006868)
1.0	7.8	GO:0051639	actin filament network formation(GO:0051639)
1.0	23.2	GO:0060351	cartilage development involved in endochondral bone morphogenesis(GO:0060351)
1.0	41.3	GO:0048009	insulin-like growth factor receptor signaling pathway(GO:0048009)
1.0	13.4	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
1.0	2.9	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
1.0	17.2	GO:0043968	histone H2A acetylation(GO:0043968)
1.0	7.6	GO:1902715	positive regulation of interferon-gamma secretion(GO:1902715)
0.9	2.8	GO:0002192	IRES-dependent translational initiation(GO:0002192)
0.9	46.4	GO:0045214	sarcomere organization(GO:0045214)
0.9	30.3	GO:0090004	positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.9	2.8	GO:1904706	negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.9	6.4	GO:0045059	positive thymic T cell selection(GO:0045059)
0.9	10.0	GO:0006782	protoporphyrinogen IX biosynthetic process(GO:0006782)
0.9	4.5	GO:0097070	ductus arteriosus closure(GO:0097070)
0.9	0.9	GO:0032349	positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.9	2.7	GO:0046061	dATP catabolic process(GO:0046061)
0.9	15.0	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.9	5.3	GO:0002315	marginal zone B cell differentiation(GO:0002315)
0.9	4.4	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.9	41.8	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.9	7.0	GO:0046116	queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.9	6.9	GO:0010044	response to aluminum ion(GO:0010044)
0.9	2.6	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.9	3.4	GO:0035795	negative regulation of mitochondrial membrane permeability(GO:0035795)
0.9	2.6	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.8	5.9	GO:0061450	trophoblast cell migration(GO:0061450)
0.8	3.4	GO:0060174	limb bud formation(GO:0060174)
0.8	20.0	GO:0031954	positive regulation of protein autophosphorylation(GO:0031954)
0.8	9.9	GO:0021520	spinal cord motor neuron cell fate specification(GO:0021520)
0.8	9.0	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.8	3.2	GO:0033132	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.8	4.8	GO:2001280	positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.8	6.4	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.8	9.4	GO:1900363	regulation of mRNA polyadenylation(GO:1900363)
0.8	6.3	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.8	17.9	GO:0030225	macrophage differentiation(GO:0030225)
0.8	0.8	GO:0060120	auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.8	7.7	GO:0016926	protein desumoylation(GO:0016926)
0.8	3.8	GO:0000960	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.8	2.3	GO:0035483	gastric emptying(GO:0035483)
0.8	2.3	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.7	2.2	GO:1903715	regulation of aerobic respiration(GO:1903715)
0.7	8.1	GO:2000641	regulation of early endosome to late endosome transport(GO:2000641)
0.7	8.8	GO:2000615	regulation of histone H3-K9 acetylation(GO:2000615)
0.7	24.9	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.7	7.3	GO:0015886	heme transport(GO:0015886)
0.7	2.9	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.7	5.7	GO:0060872	semicircular canal morphogenesis(GO:0048752) semicircular canal development(GO:0060872)
0.7	1.4	GO:1990169	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.7	2.8	GO:2000628	regulation of miRNA metabolic process(GO:2000628)
0.7	3.5	GO:0050917	sensory perception of umami taste(GO:0050917)
0.7	4.9	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.7	2.8	GO:0019072	viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.7	2.1	GO:0097010	eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.7	2.7	GO:0007182	common-partner SMAD protein phosphorylation(GO:0007182)
0.7	19.1	GO:0006958	complement activation, classical pathway(GO:0006958)
0.7	2.0	GO:0042414	epinephrine metabolic process(GO:0042414)
0.7	6.0	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.7	18.1	GO:0043171	peptide catabolic process(GO:0043171)
0.7	2.0	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.7	1.3	GO:0060154	cellular process regulating host cell cycle in response to virus(GO:0060154)
0.6	14.7	GO:0001522	pseudouridine synthesis(GO:0001522)
0.6	2.5	GO:0060454	positive regulation of gastric acid secretion(GO:0060454)
0.6	1.3	GO:1904373	response to kainic acid(GO:1904373)
0.6	1.9	GO:0060086	circadian temperature homeostasis(GO:0060086)
0.6	1.9	GO:0061043	positive regulation of vascular wound healing(GO:0035470) regulation of vascular wound healing(GO:0061043)
0.6	3.1	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.6	6.8	GO:0006336	DNA replication-independent nucleosome assembly(GO:0006336)
0.6	6.0	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.6	21.5	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.6	18.7	GO:0015804	neutral amino acid transport(GO:0015804)
0.6	1.7	GO:0009197	dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.6	11.0	GO:0042036	negative regulation of cytokine biosynthetic process(GO:0042036)
0.6	2.9	GO:1903142	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.6	1.7	GO:2000872	positive regulation of progesterone secretion(GO:2000872)
0.6	12.0	GO:0042573	retinoic acid metabolic process(GO:0042573)
0.6	4.0	GO:0035879	plasma membrane lactate transport(GO:0035879)
0.6	1.1	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.6	7.2	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
0.6	8.3	GO:1902358	sulfate transport(GO:0008272) oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.6	3.9	GO:0003374	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.5	15.3	GO:0045839	negative regulation of mitotic nuclear division(GO:0045839)
0.5	6.9	GO:0006308	DNA catabolic process(GO:0006308)
0.5	1.6	GO:1903413	cellular response to bile acid(GO:1903413)
0.5	4.8	GO:0015747	urate transport(GO:0015747)
0.5	2.6	GO:0030421	defecation(GO:0030421)
0.5	12.1	GO:0061462	protein localization to lysosome(GO:0061462)
0.5	5.2	GO:0045351	type I interferon biosynthetic process(GO:0045351)
0.5	29.2	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5	15.1	GO:0005978	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.5	3.1	GO:0015866	ADP transport(GO:0015866)
0.5	8.3	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.5	5.7	GO:0040034	regulation of development, heterochronic(GO:0040034)
0.5	5.2	GO:0070257	positive regulation of mucus secretion(GO:0070257)
0.5	8.2	GO:0000076	DNA replication checkpoint(GO:0000076)
0.5	1.5	GO:0070084	protein initiator methionine removal(GO:0070084)
0.5	1.5	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.5	3.5	GO:0015871	choline transport(GO:0015871)
0.5	4.9	GO:0006265	DNA topological change(GO:0006265)
0.5	4.4	GO:0046085	adenosine metabolic process(GO:0046085)
0.5	2.0	GO:0032808	lacrimal gland development(GO:0032808)
0.5	13.8	GO:0048266	behavioral response to pain(GO:0048266)
0.5	2.4	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.5	2.4	GO:0071340	skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.5	3.7	GO:0003416	endochondral bone growth(GO:0003416)
0.5	1.4	GO:0016129	phytosteroid metabolic process(GO:0016128) phytosteroid biosynthetic process(GO:0016129)
0.4	9.7	GO:0006884	cell volume homeostasis(GO:0006884)
0.4	1.3	GO:2000312	regulation of kainate selective glutamate receptor activity(GO:2000312)
0.4	13.3	GO:0015991	ATP hydrolysis coupled proton transport(GO:0015991)
0.4	10.7	GO:0072661	protein targeting to plasma membrane(GO:0072661)
0.4	1.3	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.4	5.1	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.4	1.3	GO:0021539	subthalamus development(GO:0021539)
0.4	1.7	GO:1901894	regulation of calcium-transporting ATPase activity(GO:1901894)
0.4	0.8	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.4	15.0	GO:0045604	regulation of epidermal cell differentiation(GO:0045604)
0.4	7.2	GO:0070266	necroptotic process(GO:0070266)
0.4	13.5	GO:0050873	brown fat cell differentiation(GO:0050873)
0.4	2.0	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.4	12.8	GO:0097502	mannosylation(GO:0097502)
0.4	15.8	GO:0006739	NADP metabolic process(GO:0006739)
0.4	3.1	GO:0032025	response to cobalt ion(GO:0032025)
0.4	3.4	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.4	1.9	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.4	1.9	GO:2000767	positive regulation of cytoplasmic translation(GO:2000767)
0.4	3.0	GO:0038180	nerve growth factor signaling pathway(GO:0038180)
0.4	1.9	GO:0032790	ribosome disassembly(GO:0032790)
0.4	1.9	GO:1904995	negative regulation of leukocyte tethering or rolling(GO:1903237) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.4	5.9	GO:0006895	Golgi to endosome transport(GO:0006895)
0.4	8.1	GO:0019835	cytolysis(GO:0019835)
0.4	4.1	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.4	1.5	GO:0071955	recycling endosome to Golgi transport(GO:0071955)
0.4	3.2	GO:0044090	positive regulation of vacuole organization(GO:0044090)
0.3	6.2	GO:0043153	entrainment of circadian clock by photoperiod(GO:0043153)
0.3	7.9	GO:0040019	positive regulation of embryonic development(GO:0040019)
0.3	4.7	GO:0030071	regulation of mitotic metaphase/anaphase transition(GO:0030071)
0.3	2.7	GO:0010866	regulation of triglyceride biosynthetic process(GO:0010866)
0.3	2.7	GO:0043102	amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.3	3.3	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.3	7.2	GO:0016226	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.3	4.9	GO:1901976	regulation of cell cycle checkpoint(GO:1901976)
0.3	1.6	GO:0010939	regulation of necrotic cell death(GO:0010939)
0.3	0.3	GO:0021593	rhombomere morphogenesis(GO:0021593)
0.3	1.3	GO:0046351	disaccharide biosynthetic process(GO:0046351)
0.3	3.9	GO:0046325	negative regulation of glucose import(GO:0046325)
0.3	1.0	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.3	2.9	GO:2000778	positive regulation of interleukin-6 secretion(GO:2000778)
0.3	13.8	GO:0006953	acute-phase response(GO:0006953)
0.3	29.0	GO:0000724	double-strand break repair via homologous recombination(GO:0000724)
0.3	4.1	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.3	0.3	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway(GO:0034136)
0.3	1.8	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.3	3.3	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.3	8.3	GO:0006099	tricarboxylic acid cycle(GO:0006099)
0.3	1.5	GO:0044351	macropinocytosis(GO:0044351)
0.3	2.0	GO:0006517	protein deglycosylation(GO:0006517)
0.3	1.5	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.3	2.3	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3	12.4	GO:0030500	regulation of bone mineralization(GO:0030500)
0.3	1.4	GO:0071233	cellular response to leucine(GO:0071233)
0.3	0.5	GO:1904578	response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.3	8.1	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.3	20.5	GO:0048706	embryonic skeletal system development(GO:0048706)
0.3	3.5	GO:0001702	gastrulation with mouth forming second(GO:0001702)
0.3	0.8	GO:0071031	nuclear mRNA surveillance of mRNA 3'-end processing(GO:0071031) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
0.3	1.0	GO:0009649	entrainment of circadian clock(GO:0009649)
0.3	2.8	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.2	10.8	GO:0046676	negative regulation of insulin secretion(GO:0046676)
0.2	4.4	GO:0090161	Golgi ribbon formation(GO:0090161)
0.2	6.2	GO:0048538	thymus development(GO:0048538)
0.2	2.1	GO:0060211	regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.2	1.4	GO:0071918	urea transmembrane transport(GO:0071918)
0.2	21.0	GO:0048678	response to axon injury(GO:0048678)
0.2	2.5	GO:0019432	triglyceride biosynthetic process(GO:0019432)
0.2	2.0	GO:0006983	ER overload response(GO:0006983)
0.2	15.1	GO:0043473	pigmentation(GO:0043473)
0.2	6.3	GO:0006024	glycosaminoglycan biosynthetic process(GO:0006024)
0.2	0.9	GO:0015936	coenzyme A metabolic process(GO:0015936)
0.2	5.0	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.2	0.9	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
0.2	12.4	GO:0030177	positive regulation of Wnt signaling pathway(GO:0030177)
0.2	2.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.2	3.4	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.2	0.8	GO:0033326	cerebrospinal fluid secretion(GO:0033326)
0.2	9.6	GO:0043966	histone H3 acetylation(GO:0043966)
0.2	26.5	GO:0042113	B cell activation(GO:0042113)
0.2	3.5	GO:0060712	spongiotrophoblast layer development(GO:0060712)
0.2	2.3	GO:0046457	prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.2	0.6	GO:0045792	negative regulation of cell size(GO:0045792)
0.2	0.7	GO:0010138	pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) UMP salvage(GO:0044206)
0.2	8.0	GO:0031338	regulation of vesicle fusion(GO:0031338)
0.2	2.9	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2	5.3	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.2	0.5	GO:0097498	endothelial tube lumen extension(GO:0097498)
0.2	3.9	GO:0072676	lymphocyte migration(GO:0072676)
0.2	1.2	GO:0002063	chondrocyte development(GO:0002063)
0.2	1.2	GO:1904294	positive regulation of ERAD pathway(GO:1904294)
0.2	4.7	GO:0035458	cellular response to interferon-beta(GO:0035458)
0.2	0.3	GO:0061534	gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.2	5.7	GO:0097421	liver regeneration(GO:0097421)
0.2	4.8	GO:0070936	protein K48-linked ubiquitination(GO:0070936)
0.2	6.2	GO:0032945	negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.2	0.5	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.2	2.9	GO:0030033	microvillus assembly(GO:0030033)
0.2	1.4	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.2	2.3	GO:0000132	establishment of mitotic spindle orientation(GO:0000132)
0.2	7.1	GO:2000181	negative regulation of angiogenesis(GO:0016525) negative regulation of blood vessel morphogenesis(GO:2000181)
0.2	9.9	GO:1902476	chloride transmembrane transport(GO:1902476)
0.1	1.0	GO:0007256	activation of JNKK activity(GO:0007256)
0.1	3.8	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1	3.9	GO:0006801	superoxide metabolic process(GO:0006801)
0.1	0.7	GO:0003360	brainstem development(GO:0003360)
0.1	1.1	GO:0035067	negative regulation of histone acetylation(GO:0035067)
0.1	1.3	GO:0070070	proton-transporting V-type ATPase complex assembly(GO:0070070)
0.1	1.1	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.1	6.7	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1	0.5	GO:0036506	maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1	2.8	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.1	4.8	GO:0019915	lipid storage(GO:0019915)
0.1	0.9	GO:0043686	co-translational protein modification(GO:0043686)
0.1	1.8	GO:0009060	aerobic respiration(GO:0009060)
0.1	48.4	GO:0043547	positive regulation of GTPase activity(GO:0043547)
0.1	3.6	GO:0070527	platelet aggregation(GO:0070527)
0.1	2.1	GO:0000154	rRNA modification(GO:0000154)
0.1	1.6	GO:0042407	cristae formation(GO:0042407)
0.1	0.1	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.1	0.4	GO:0014842	regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.1	1.7	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1	15.8	GO:0006486	protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.1	1.0	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1	0.6	GO:0002943	tRNA dihydrouridine synthesis(GO:0002943)
0.1	1.9	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902235)
0.1	1.8	GO:0002385	organ or tissue specific immune response(GO:0002251) mucosal immune response(GO:0002385)
0.1	0.4	GO:0090367	negative regulation of mRNA modification(GO:0090367)
0.1	6.1	GO:0009408	response to heat(GO:0009408)
0.1	0.7	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1	2.6	GO:0018345	protein palmitoylation(GO:0018345)
0.1	1.0	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.1	0.2	GO:0006045	N-acetylglucosamine biosynthetic process(GO:0006045) N-acetylneuraminate biosynthetic process(GO:0046380) glucosamine-containing compound biosynthetic process(GO:1901073)
0.1	3.1	GO:0033138	positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1	5.2	GO:0008344	adult locomotory behavior(GO:0008344)
0.1	2.0	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.1	4.8	GO:0030217	T cell differentiation(GO:0030217)
0.1	0.9	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.1	1.8	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1	5.6	GO:0002244	hematopoietic progenitor cell differentiation(GO:0002244)
0.1	0.3	GO:0070317	negative regulation of G0 to G1 transition(GO:0070317)
0.1	0.8	GO:0032288	myelin assembly(GO:0032288)
0.1	2.5	GO:0045445	myoblast differentiation(GO:0045445)
0.1	0.9	GO:0043267	negative regulation of potassium ion transport(GO:0043267)
0.1	1.5	GO:1904031	positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.1	0.2	GO:0007000	nucleolus organization(GO:0007000)
0.1	0.9	GO:0061515	myeloid cell development(GO:0061515)
0.1	4.7	GO:0071773	response to BMP(GO:0071772) cellular response to BMP stimulus(GO:0071773)
0.1	0.4	GO:0072520	seminiferous tubule development(GO:0072520)
0.1	0.4	GO:0060736	prostate gland growth(GO:0060736)
0.0	1.3	GO:0006893	Golgi to plasma membrane transport(GO:0006893)
0.0	1.5	GO:0042220	response to cocaine(GO:0042220)
0.0	0.5	GO:0035902	response to immobilization stress(GO:0035902)
0.0	0.6	GO:0031468	nuclear envelope reassembly(GO:0031468)
0.0	1.1	GO:0071300	cellular response to retinoic acid(GO:0071300)
0.0	3.2	GO:0006818	hydrogen transport(GO:0006818)
0.0	6.4	GO:0010038	response to metal ion(GO:0010038)
0.0	1.6	GO:0008286	insulin receptor signaling pathway(GO:0008286)
0.0	1.7	GO:0006334	nucleosome assembly(GO:0006334)
0.0	0.3	GO:0021554	optic nerve development(GO:0021554)
0.0	0.5	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0	0.3	GO:0051443	positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0	0.8	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.5	GO:0048747	muscle fiber development(GO:0048747)
0.0	0.3	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.7	GO:0006888	ER to Golgi vesicle-mediated transport(GO:0006888)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
13.0	64.8	GO:0005927	muscle tendon junction(GO:0005927)
9.9	39.7	GO:0061474	phagolysosome membrane(GO:0061474)
5.4	37.8	GO:0071986	Ragulator complex(GO:0071986)
5.2	15.6	GO:0005899	insulin receptor complex(GO:0005899)
5.1	15.2	GO:1990796	photoreceptor cell terminal bouton(GO:1990796)
4.7	23.6	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
4.2	42.2	GO:0005641	nuclear envelope lumen(GO:0005641)
4.2	29.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
3.7	14.9	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
3.4	16.9	GO:0097413	Lewy body(GO:0097413)
3.4	16.8	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
3.3	36.0	GO:0097418	neurofibrillary tangle(GO:0097418)
3.0	11.8	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
2.9	37.3	GO:0005885	Arp2/3 protein complex(GO:0005885)
2.8	11.2	GO:0045273	respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281)
2.7	21.8	GO:0000243	commitment complex(GO:0000243)
2.7	26.8	GO:0043020	NADPH oxidase complex(GO:0043020)
2.6	18.2	GO:0000322	storage vacuole(GO:0000322)
2.5	15.1	GO:0005879	axonemal microtubule(GO:0005879)
2.5	32.5	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
2.3	18.3	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
2.2	8.7	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
2.1	17.2	GO:0097452	GAIT complex(GO:0097452)
2.0	4.1	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
2.0	19.7	GO:0042587	glycogen granule(GO:0042587)
2.0	25.5	GO:0016342	catenin complex(GO:0016342)
1.9	21.2	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
1.9	17.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
1.9	11.4	GO:0071817	MMXD complex(GO:0071817)
1.7	3.5	GO:0030906	retromer, cargo-selective complex(GO:0030906)
1.7	13.7	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
1.7	8.5	GO:0097169	IPAF inflammasome complex(GO:0072557) AIM2 inflammasome complex(GO:0097169)
1.6	18.0	GO:0042555	MCM complex(GO:0042555)
1.6	7.9	GO:0031085	BLOC-3 complex(GO:0031085)
1.6	9.4	GO:0070765	gamma-secretase complex(GO:0070765)
1.6	14.0	GO:0033263	CORVET complex(GO:0033263)
1.5	3.1	GO:1990590	ATF1-ATF4 transcription factor complex(GO:1990590)
1.5	13.7	GO:0031082	BLOC complex(GO:0031082)
1.5	6.0	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
1.5	6.0	GO:0044393	TCR signalosome(GO:0036398) microspike(GO:0044393)
1.4	4.3	GO:1990723	cytoplasmic periphery of the nuclear pore complex(GO:1990723)
1.4	10.9	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
1.4	8.2	GO:0030896	checkpoint clamp complex(GO:0030896)
1.3	3.9	GO:0033557	Slx1-Slx4 complex(GO:0033557)
1.3	6.3	GO:0061689	tricellular tight junction(GO:0061689)
1.2	6.2	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
1.2	13.6	GO:0005797	Golgi medial cisterna(GO:0005797)
1.2	8.4	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
1.2	14.1	GO:0030008	TRAPP complex(GO:0030008)
1.2	620.1	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.2	15.0	GO:0030904	retromer complex(GO:0030904)
1.2	4.6	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
1.1	3.2	GO:1990826	nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
1.1	34.0	GO:0005721	pericentric heterochromatin(GO:0005721)
1.0	3.1	GO:0031510	SUMO activating enzyme complex(GO:0031510)
1.0	3.1	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
1.0	13.3	GO:0035253	ciliary rootlet(GO:0035253)
1.0	4.1	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
1.0	11.8	GO:0005662	DNA replication factor A complex(GO:0005662)
1.0	2.9	GO:0005960	glycine cleavage complex(GO:0005960)
1.0	10.5	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.9	91.6	GO:0016605	PML body(GO:0016605)
0.9	11.5	GO:0044666	MLL3/4 complex(GO:0044666)
0.9	7.0	GO:0001940	male pronucleus(GO:0001940)
0.9	6.1	GO:0005827	polar microtubule(GO:0005827)
0.9	7.7	GO:0000813	ESCRT I complex(GO:0000813)
0.8	6.4	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.8	7.2	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.8	3.2	GO:1990630	IRE1-RACK1-PP2A complex(GO:1990630)
0.8	5.4	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.8	20.9	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.8	2.3	GO:0071149	TEAD-1-YAP complex(GO:0071148) TEAD-2-YAP complex(GO:0071149)
0.7	11.2	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.7	5.0	GO:0098797	plasma membrane protein complex(GO:0098797)
0.7	2.1	GO:0061673	mitotic spindle astral microtubule(GO:0061673)
0.7	3.4	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.7	10.3	GO:0032591	dendritic spine membrane(GO:0032591)
0.7	4.7	GO:0042382	paraspeckles(GO:0042382)
0.7	8.7	GO:0030914	STAGA complex(GO:0030914)
0.7	5.3	GO:0065010	extracellular membrane-bounded organelle(GO:0065010)
0.7	13.8	GO:0031528	microvillus membrane(GO:0031528)
0.6	9.5	GO:0035102	PRC1 complex(GO:0035102)
0.6	15.8	GO:0032839	dendrite cytoplasm(GO:0032839)
0.6	3.6	GO:0001651	dense fibrillar component(GO:0001651)
0.6	4.8	GO:0042613	MHC class II protein complex(GO:0042613)
0.6	3.0	GO:0048179	activin receptor complex(GO:0048179)
0.6	1.8	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.6	1.8	GO:0045203	intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
0.6	37.0	GO:0000792	heterochromatin(GO:0000792)
0.6	2.9	GO:0005642	annulate lamellae(GO:0005642)
0.6	9.6	GO:0005685	U1 snRNP(GO:0005685)
0.6	7.8	GO:0001891	phagocytic cup(GO:0001891)
0.5	15.9	GO:0001772	immunological synapse(GO:0001772)
0.5	37.1	GO:0030136	clathrin-coated vesicle(GO:0030136)
0.5	33.7	GO:1903293	phosphatase complex(GO:1903293)
0.5	12.9	GO:0000242	pericentriolar material(GO:0000242)
0.5	33.5	GO:0005811	lipid particle(GO:0005811)
0.5	75.6	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.5	8.6	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.5	26.2	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.5	1.5	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.5	2.0	GO:0071010	prespliceosome(GO:0071010)
0.5	1.5	GO:0005818	astral microtubule(GO:0000235) aster(GO:0005818)
0.5	1.5	GO:0045025	mitochondrial degradosome(GO:0045025)
0.5	5.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.5	9.3	GO:0016460	myosin II complex(GO:0016460)
0.5	18.6	GO:0009925	basal plasma membrane(GO:0009925)
0.5	31.5	GO:0031526	brush border membrane(GO:0031526)
0.5	5.0	GO:0044294	dendritic growth cone(GO:0044294)
0.4	33.4	GO:0005770	late endosome(GO:0005770)
0.4	1.3	GO:0044308	axonal spine(GO:0044308)
0.4	9.2	GO:0035371	microtubule plus-end(GO:0035371)
0.4	4.5	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.4	2.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.4	7.4	GO:0031430	M band(GO:0031430)
0.4	17.8	GO:0005776	autophagosome(GO:0005776)
0.4	7.6	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.4	24.9	GO:0005901	caveola(GO:0005901)
0.4	17.1	GO:0005871	kinesin complex(GO:0005871)
0.4	14.1	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.4	1.8	GO:0070761	pre-snoRNP complex(GO:0070761)
0.3	15.0	GO:0045171	intercellular bridge(GO:0045171)
0.3	7.0	GO:0005640	nuclear outer membrane(GO:0005640)
0.3	2.8	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.3	8.6	GO:0035145	exon-exon junction complex(GO:0035145)
0.3	4.8	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.3	2.9	GO:0008290	F-actin capping protein complex(GO:0008290)
0.3	1.9	GO:0042788	polysomal ribosome(GO:0042788)
0.3	1.2	GO:0042405	nuclear inclusion body(GO:0042405)
0.3	1.5	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3	4.6	GO:0030126	COPI vesicle coat(GO:0030126)
0.3	42.2	GO:0005681	spliceosomal complex(GO:0005681)
0.3	0.6	GO:1990730	VCP-NSFL1C complex(GO:1990730)
0.3	7.0	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.3	25.5	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.3	2.4	GO:0099634	postsynaptic specialization membrane(GO:0099634)
0.3	5.3	GO:0005614	interstitial matrix(GO:0005614)
0.3	30.0	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3	0.8	GO:0032593	insulin-responsive compartment(GO:0032593)
0.3	3.9	GO:0044217	other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.3	0.5	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.3	11.2	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.3	3.3	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3	58.4	GO:0031965	nuclear membrane(GO:0031965)
0.2	1.0	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.2	3.4	GO:0000346	transcription export complex(GO:0000346)
0.2	22.1	GO:0005769	early endosome(GO:0005769)
0.2	1.4	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.2	11.4	GO:0005657	replication fork(GO:0005657)
0.2	1.1	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.2	1.6	GO:0061617	MICOS complex(GO:0061617)
0.2	7.6	GO:0060077	inhibitory synapse(GO:0060077)
0.2	0.9	GO:0042824	MHC class I peptide loading complex(GO:0042824)
0.2	0.8	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.2	24.9	GO:0001650	fibrillar center(GO:0001650)
0.2	2.4	GO:0030666	endocytic vesicle membrane(GO:0030666)
0.2	5.1	GO:0000788	nuclear nucleosome(GO:0000788)
0.2	100.7	GO:0016604	nuclear body(GO:0016604)
0.2	9.5	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2	11.8	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.2	0.6	GO:0031931	TORC1 complex(GO:0031931)
0.2	11.3	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2	2.0	GO:0031258	lamellipodium membrane(GO:0031258)
0.2	17.3	GO:0032993	protein-DNA complex(GO:0032993)
0.2	27.7	GO:0005925	focal adhesion(GO:0005925)
0.2	9.2	GO:0005581	collagen trimer(GO:0005581)
0.2	0.7	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.2	2.7	GO:0016459	myosin complex(GO:0016459)
0.2	4.3	GO:0070382	exocytic vesicle(GO:0070382)
0.2	1.1	GO:0005652	nuclear lamina(GO:0005652)
0.2	62.8	GO:0005740	mitochondrial envelope(GO:0005740)
0.1	0.7	GO:0045098	type III intermediate filament(GO:0045098)
0.1	2.8	GO:0005680	anaphase-promoting complex(GO:0005680)
0.1	5.4	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.1	326.0	GO:0070062	extracellular exosome(GO:0070062)
0.1	3.8	GO:0005768	endosome(GO:0005768)
0.1	4.0	GO:0000118	histone deacetylase complex(GO:0000118)
0.1	36.3	GO:0000139	Golgi membrane(GO:0000139)
0.1	4.2	GO:0055037	recycling endosome(GO:0055037)
0.1	4.4	GO:0005774	vacuolar membrane(GO:0005774)
0.1	1.7	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1	3.2	GO:0015935	small ribosomal subunit(GO:0015935)
0.1	1.4	GO:0031672	A band(GO:0031672)
0.1	1.7	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.1	2.6	GO:0097060	synaptic membrane(GO:0097060)
0.1	3.4	GO:0005840	ribosome(GO:0005840)
0.1	1.3	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.1	1.7	GO:0005604	basement membrane(GO:0005604)
0.1	0.9	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.1	1.7	GO:0030686	90S preribosome(GO:0030686)
0.1	0.9	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.1	24.4	GO:0005730	nucleolus(GO:0005730)
0.1	1.7	GO:0098802	plasma membrane receptor complex(GO:0098802)
0.1	3.3	GO:0001726	ruffle(GO:0001726)
0.1	1.2	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1	12.9	GO:0000785	chromatin(GO:0000785)
0.1	0.4	GO:0046930	pore complex(GO:0046930)
0.0	2.4	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	0.1	GO:0031045	dense core granule(GO:0031045)
0.0	30.0	GO:0005739	mitochondrion(GO:0005739)
0.0	16.4	GO:0030054	cell junction(GO:0030054)
0.0	4.1	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	108.0	GO:0016021	integral component of membrane(GO:0016021)
0.0	2.3	GO:0016324	apical plasma membrane(GO:0016324)
0.0	14.8	GO:0005783	endoplasmic reticulum(GO:0005783)
0.0	0.2	GO:0045177	apical part of cell(GO:0045177)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
31.3	125.2	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
14.9	59.6	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
13.4	53.5	GO:0030984	kininogen binding(GO:0030984)
12.0	36.0	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
8.6	25.9	GO:0004370	glycerol kinase activity(GO:0004370)
7.9	23.6	GO:0004874	aryl hydrocarbon receptor activity(GO:0004874)
7.9	23.6	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
7.3	22.0	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
6.5	19.5	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
6.3	6.3	GO:0070506	high-density lipoprotein particle receptor activity(GO:0070506)
6.2	18.7	GO:0008948	oxaloacetate decarboxylase activity(GO:0008948) hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
6.1	18.2	GO:0016230	sphingomyelin phosphodiesterase activator activity(GO:0016230)
5.9	29.4	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
5.7	17.0	GO:0031871	proteinase activated receptor binding(GO:0031871)
5.3	26.4	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
5.3	47.3	GO:0031995	insulin-like growth factor II binding(GO:0031995)
5.1	40.9	GO:0016936	galactoside binding(GO:0016936)
5.0	40.3	GO:0031419	cobalamin binding(GO:0031419)
4.6	27.8	GO:0051434	BH3 domain binding(GO:0051434)
4.6	13.7	GO:1990460	leptin receptor binding(GO:1990460)
4.5	18.1	GO:0008240	tripeptidyl-peptidase activity(GO:0008240)
4.5	35.8	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
4.4	13.3	GO:0001069	regulatory region RNA binding(GO:0001069)
4.3	17.0	GO:1990189	peptide-serine-N-acetyltransferase activity(GO:1990189)
4.2	12.5	GO:0004392	heme oxygenase (decyclizing) activity(GO:0004392)
4.1	37.3	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
4.1	20.6	GO:0004945	angiotensin type II receptor activity(GO:0004945)
3.9	19.5	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
3.5	31.9	GO:0032050	clathrin heavy chain binding(GO:0032050)
3.5	66.9	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
3.5	24.4	GO:0033592	RNA strand annealing activity(GO:0033592)
3.4	13.7	GO:0005163	nerve growth factor receptor binding(GO:0005163)
3.4	16.8	GO:0034186	apolipoprotein A-I binding(GO:0034186)
3.3	10.0	GO:1990050	phosphatidic acid transporter activity(GO:1990050)
3.2	38.2	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
3.1	24.6	GO:0008430	selenium binding(GO:0008430)
3.0	12.2	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
2.8	17.0	GO:0070180	large ribosomal subunit rRNA binding(GO:0070180)
2.8	11.2	GO:0000104	succinate dehydrogenase activity(GO:0000104)
2.8	11.2	GO:0019776	Atg8 ligase activity(GO:0019776)
2.8	13.8	GO:0051032	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
2.7	21.3	GO:0045545	syndecan binding(GO:0045545)
2.6	10.4	GO:0004949	cannabinoid receptor activity(GO:0004949)
2.5	7.6	GO:0005302	L-tyrosine transmembrane transporter activity(GO:0005302)
2.5	27.9	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
2.5	4.9	GO:0015186	L-glutamine transmembrane transporter activity(GO:0015186)
2.5	12.3	GO:0019770	IgG receptor activity(GO:0019770)
2.4	9.7	GO:0016833	oxo-acid-lyase activity(GO:0016833)
2.4	26.1	GO:0042577	lipid phosphatase activity(GO:0042577)
2.3	9.4	GO:0035614	snRNA stem-loop binding(GO:0035614)
2.3	7.0	GO:0005119	smoothened binding(GO:0005119)
2.3	16.2	GO:0031852	mu-type opioid receptor binding(GO:0031852)
2.3	20.5	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
2.2	17.5	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
2.2	15.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
2.1	6.2	GO:0005483	soluble NSF attachment protein activity(GO:0005483)
2.0	20.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
2.0	11.8	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
1.9	5.7	GO:0008476	protein-tyrosine sulfotransferase activity(GO:0008476)
1.9	11.5	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
1.9	9.5	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
1.8	14.7	GO:0031386	protein tag(GO:0031386)
1.8	9.2	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
1.8	7.3	GO:0015184	L-cystine transmembrane transporter activity(GO:0015184)
1.8	10.9	GO:0042289	MHC class II protein binding(GO:0042289)
1.8	32.6	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
1.8	7.2	GO:0052794	exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
1.8	5.3	GO:0033906	hyaluronoglucuronidase activity(GO:0033906)
1.7	7.0	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
1.7	6.9	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
1.7	6.8	GO:0005534	galactose binding(GO:0005534)
1.7	13.4	GO:0035184	histone threonine kinase activity(GO:0035184)
1.7	5.0	GO:0017042	glycosylceramidase activity(GO:0017042)
1.6	8.2	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
1.6	6.4	GO:1904288	BAT3 complex binding(GO:1904288)
1.6	4.8	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.6	14.4	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
1.6	4.8	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
1.6	9.4	GO:0001849	complement component C1q binding(GO:0001849)
1.6	15.6	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
1.6	4.7	GO:0031432	titin binding(GO:0031432)
1.5	7.6	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
1.4	11.4	GO:0046527	glucosyltransferase activity(GO:0046527)
1.4	4.2	GO:0004911	interleukin-2 receptor activity(GO:0004911)
1.4	16.9	GO:0019911	structural constituent of myelin sheath(GO:0019911)
1.4	4.2	GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
1.4	25.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
1.4	15.2	GO:0050544	arachidonic acid binding(GO:0050544)
1.4	31.5	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
1.3	24.1	GO:0004602	glutathione peroxidase activity(GO:0004602)
1.3	19.0	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
1.3	12.6	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
1.3	2.5	GO:0004698	calcium-dependent protein kinase C activity(GO:0004698)
1.2	3.7	GO:0004574	oligo-1,6-glucosidase activity(GO:0004574)
1.2	13.7	GO:0005346	adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346)
1.2	9.9	GO:0016421	CoA carboxylase activity(GO:0016421)
1.2	9.7	GO:1990825	sequence-specific mRNA binding(GO:1990825)
1.2	7.2	GO:0046624	sphingolipid transporter activity(GO:0046624)
1.2	6.0	GO:0097016	L27 domain binding(GO:0097016)
1.2	7.2	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
1.2	30.0	GO:0008198	ferrous iron binding(GO:0008198)
1.2	4.8	GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
1.2	21.1	GO:0044548	S100 protein binding(GO:0044548)
1.1	11.5	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
1.1	21.3	GO:0016881	acid-amino acid ligase activity(GO:0016881)
1.1	8.9	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
1.1	8.7	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
1.1	23.5	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
1.1	48.0	GO:0048365	Rac GTPase binding(GO:0048365)
1.1	8.5	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
1.1	6.4	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
1.1	50.9	GO:0019213	deacetylase activity(GO:0019213)
1.1	11.6	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
1.0	3.1	GO:0044388	small protein activating enzyme binding(GO:0044388)
1.0	9.4	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.0	7.2	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
1.0	4.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
1.0	4.1	GO:0004594	pantothenate kinase activity(GO:0004594)
1.0	6.0	GO:0043426	MRF binding(GO:0043426)
1.0	1.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.0	3.0	GO:0019912	cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.0	14.7	GO:0009982	pseudouridine synthase activity(GO:0009982)
1.0	2.9	GO:0004159	dihydrouracil dehydrogenase (NAD+) activity(GO:0004159) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
1.0	4.9	GO:0034597	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
1.0	21.4	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
1.0	41.6	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.0	3.8	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
1.0	2.9	GO:0051425	PTB domain binding(GO:0051425)
0.9	10.4	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.9	4.7	GO:0001042	RNA polymerase I core binding(GO:0001042)
0.9	12.3	GO:0042609	CD4 receptor binding(GO:0042609)
0.9	17.9	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.9	20.5	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.9	2.8	GO:0004736	pyruvate carboxylase activity(GO:0004736)
0.9	2.8	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.9	5.4	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.9	10.0	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.9	6.3	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.9	7.1	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.9	7.1	GO:0003680	AT DNA binding(GO:0003680)
0.9	6.2	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.9	7.0	GO:0008479	queuine tRNA-ribosyltransferase activity(GO:0008479)
0.9	6.0	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.8	4.2	GO:0015166	polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
0.8	4.9	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.8	11.5	GO:0008373	sialyltransferase activity(GO:0008373)
0.8	7.3	GO:0015232	heme transporter activity(GO:0015232)
0.8	20.9	GO:0004190	aspartic-type endopeptidase activity(GO:0004190)
0.8	3.2	GO:0016426	tRNA (adenine) methyltransferase activity(GO:0016426)
0.8	38.2	GO:0005507	copper ion binding(GO:0005507)
0.8	9.3	GO:0070700	BMP receptor binding(GO:0070700)
0.8	8.5	GO:0097200	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153) cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.8	7.7	GO:0016929	SUMO-specific protease activity(GO:0016929)
0.8	23.9	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.8	1.5	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.8	4.5	GO:0070403	NAD+ binding(GO:0070403)
0.8	16.5	GO:0008327	methyl-CpG binding(GO:0008327)
0.8	36.8	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
0.7	15.3	GO:0005521	lamin binding(GO:0005521)
0.7	3.6	GO:0044547	DNA topoisomerase binding(GO:0044547)
0.7	10.8	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.7	10.0	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.7	12.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.7	3.5	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.7	2.7	GO:0050693	LBD domain binding(GO:0050693)
0.7	30.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.7	6.1	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.7	5.3	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.7	26.5	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.7	6.0	GO:0008381	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.7	48.2	GO:0032947	protein complex scaffold(GO:0032947)
0.6	9.7	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.6	10.2	GO:0017166	vinculin binding(GO:0017166)
0.6	2.5	GO:0086089	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.6	8.2	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.6	8.1	GO:0003796	lysozyme activity(GO:0003796)
0.6	1.2	GO:0051538	3 iron, 4 sulfur cluster binding(GO:0051538)
0.6	4.8	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.6	22.0	GO:0016831	carboxy-lyase activity(GO:0016831)
0.6	1.8	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.6	2.9	GO:0031994	insulin-like growth factor I binding(GO:0031994) neuregulin binding(GO:0038132)
0.6	5.3	GO:0015250	water channel activity(GO:0015250)
0.6	4.1	GO:0019238	cyclohydrolase activity(GO:0019238)
0.6	1.7	GO:0009041	uridylate kinase activity(GO:0009041) nucleoside phosphate kinase activity(GO:0050145)
0.6	2.9	GO:0042608	T cell receptor binding(GO:0042608)
0.6	26.4	GO:1901476	carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.6	9.2	GO:0031005	filamin binding(GO:0031005)
0.6	15.5	GO:0036002	pre-mRNA binding(GO:0036002)
0.6	3.4	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.6	7.3	GO:0003688	DNA replication origin binding(GO:0003688)
0.6	6.2	GO:0071837	HMG box domain binding(GO:0071837)
0.5	18.7	GO:0015175	neutral amino acid transmembrane transporter activity(GO:0015175)
0.5	11.0	GO:0000030	mannosyltransferase activity(GO:0000030)
0.5	3.7	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.5	2.7	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.5	39.5	GO:0003727	single-stranded RNA binding(GO:0003727)
0.5	12.8	GO:0042288	MHC class I protein binding(GO:0042288)
0.5	6.4	GO:1990405	protein antigen binding(GO:1990405)
0.5	3.7	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.5	2.5	GO:0090554	phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.5	1.5	GO:0009384	N-acylmannosamine kinase activity(GO:0009384)
0.5	2.5	GO:0032051	clathrin light chain binding(GO:0032051)
0.5	4.0	GO:0043495	protein anchor(GO:0043495)
0.5	1.5	GO:0045340	mercury ion binding(GO:0045340)
0.5	2.5	GO:0003988	acetyl-CoA C-acyltransferase activity(GO:0003988)
0.5	4.0	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.5	144.7	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.5	12.7	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.5	28.8	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.5	55.4	GO:0017124	SH3 domain binding(GO:0017124)
0.5	20.9	GO:0005080	protein kinase C binding(GO:0005080)
0.5	9.5	GO:0005158	insulin receptor binding(GO:0005158)
0.5	3.3	GO:0015119	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.5	1.4	GO:0004661	protein geranylgeranyltransferase activity(GO:0004661)
0.5	1.9	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.5	6.9	GO:0036442	hydrogen-exporting ATPase activity(GO:0036442)
0.5	25.7	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.4	3.6	GO:0051400	BH domain binding(GO:0051400)
0.4	10.3	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.4	13.4	GO:0008536	Ran GTPase binding(GO:0008536)
0.4	12.6	GO:0019200	carbohydrate kinase activity(GO:0019200)
0.4	9.4	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.4	1.3	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.4	1.3	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.4	2.9	GO:0017070	U6 snRNA binding(GO:0017070)
0.4	2.9	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.4	19.5	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.4	1.2	GO:0008254	3'-nucleotidase activity(GO:0008254)
0.4	2.5	GO:0008172	S-methyltransferase activity(GO:0008172)
0.4	1.2	GO:0016748	succinyltransferase activity(GO:0016748)
0.4	3.5	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.4	7.1	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.4	6.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.4	2.7	GO:0032554	purine deoxyribonucleotide binding(GO:0032554)
0.4	1.9	GO:1990226	histone methyltransferase binding(GO:1990226)
0.4	11.8	GO:0005504	fatty acid binding(GO:0005504)
0.4	3.3	GO:0043295	glutathione binding(GO:0043295)
0.4	2.9	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.4	35.7	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.4	2.5	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.4	2.8	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.4	3.9	GO:0048185	activin binding(GO:0048185)
0.3	1.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.3	5.2	GO:0031996	thioesterase binding(GO:0031996)
0.3	9.6	GO:0008378	galactosyltransferase activity(GO:0008378)
0.3	2.4	GO:0034185	apolipoprotein binding(GO:0034185)
0.3	15.8	GO:0051287	NAD binding(GO:0051287)
0.3	4.0	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.3	15.1	GO:0019894	kinesin binding(GO:0019894)
0.3	1.2	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.3	14.5	GO:0004521	endoribonuclease activity(GO:0004521)
0.3	5.8	GO:0051010	microtubule plus-end binding(GO:0051010)
0.3	3.3	GO:0030215	semaphorin receptor binding(GO:0030215)
0.3	0.9	GO:0046978	TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.3	3.7	GO:0042043	neurexin family protein binding(GO:0042043)
0.3	1.4	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.3	9.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.3	0.5	GO:0016882	cyclo-ligase activity(GO:0016882)
0.3	7.3	GO:0050699	WW domain binding(GO:0050699)
0.3	43.8	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.3	3.3	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.2	3.4	GO:0017154	semaphorin receptor activity(GO:0017154)
0.2	1.2	GO:0031685	adenosine receptor binding(GO:0031685)
0.2	18.9	GO:0042626	ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.2	9.3	GO:0030295	protein kinase activator activity(GO:0030295)
0.2	12.6	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2	15.4	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.2	4.0	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.2	1.7	GO:0070087	chromo shadow domain binding(GO:0070087)
0.2	3.1	GO:0001671	ATPase activator activity(GO:0001671)
0.2	46.9	GO:0005096	GTPase activator activity(GO:0005096)
0.2	4.9	GO:0017147	Wnt-protein binding(GO:0017147)
0.2	6.2	GO:0046332	SMAD binding(GO:0046332)
0.2	5.0	GO:0035258	steroid hormone receptor binding(GO:0035258)
0.2	9.4	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.2	10.8	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2	2.9	GO:0042056	chemoattractant activity(GO:0042056)
0.2	1.9	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.2	97.0	GO:0003700	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2	2.0	GO:0016868	intramolecular transferase activity, phosphotransferases(GO:0016868)
0.2	1.3	GO:0016681	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2	2.5	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.1	6.0	GO:0005484	SNAP receptor activity(GO:0005484)
0.1	0.6	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1	21.6	GO:0005125	cytokine activity(GO:0005125)
0.1	2.3	GO:0004364	glutathione transferase activity(GO:0004364)
0.1	1.3	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1	2.0	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1	0.8	GO:0030274	LIM domain binding(GO:0030274)
0.1	1.6	GO:0008097	5S rRNA binding(GO:0008097)
0.1	1.2	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1	1.3	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.1	1.6	GO:0004697	protein kinase C activity(GO:0004697)
0.1	2.9	GO:0035254	glutamate receptor binding(GO:0035254)
0.1	1.3	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.1	10.2	GO:0030165	PDZ domain binding(GO:0030165)
0.1	1.8	GO:0017080	sodium channel regulator activity(GO:0017080)
0.1	1.4	GO:0004016	adenylate cyclase activity(GO:0004016) guanylate cyclase activity(GO:0004383)
0.1	2.8	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.1	1.2	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1	1.9	GO:1901505	carbohydrate derivative transporter activity(GO:1901505)
0.1	2.3	GO:0033613	activating transcription factor binding(GO:0033613)
0.1	0.5	GO:0001729	ceramide kinase activity(GO:0001729)
0.1	0.9	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.1	0.6	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.1	3.3	GO:0005246	calcium channel regulator activity(GO:0005246)
0.1	3.7	GO:0008080	N-acetyltransferase activity(GO:0008080)
0.1	1.9	GO:0005326	neurotransmitter transporter activity(GO:0005326)
0.1	0.8	GO:0031748	D1 dopamine receptor binding(GO:0031748)
0.1	6.4	GO:0051219	phosphoprotein binding(GO:0051219)
0.1	15.5	GO:0000287	magnesium ion binding(GO:0000287)
0.1	1.6	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1	4.1	GO:0051087	chaperone binding(GO:0051087)
0.1	0.6	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1	3.7	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.1	0.3	GO:0030622	U4 snRNA binding(GO:0030621) U4atac snRNA binding(GO:0030622)
0.1	1.0	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1	8.9	GO:0051015	actin filament binding(GO:0051015)
0.1	11.5	GO:0004866	endopeptidase inhibitor activity(GO:0004866)
0.1	2.6	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1	20.3	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	0.2	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.1	1.3	GO:0015299	solute:proton antiporter activity(GO:0015299)
0.1	21.6	GO:0019904	protein domain specific binding(GO:0019904)
0.1	10.7	GO:0046906	tetrapyrrole binding(GO:0046906)
0.1	10.0	GO:0016874	ligase activity(GO:0016874)
0.1	2.9	GO:0005044	scavenger receptor activity(GO:0005044)
0.1	0.9	GO:0016854	racemase and epimerase activity(GO:0016854)
0.1	0.9	GO:0004576	oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1	1.5	GO:0001786	phosphatidylserine binding(GO:0001786)
0.1	5.7	GO:0004713	protein tyrosine kinase activity(GO:0004713)
0.1	1.6	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.1	11.7	GO:0003924	GTPase activity(GO:0003924)
0.1	3.4	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.1	0.4	GO:0008061	chitin binding(GO:0008061)
0.0	0.8	GO:0005112	Notch binding(GO:0005112)
0.0	1.7	GO:0015078	hydrogen ion transmembrane transporter activity(GO:0015078)
0.0	3.0	GO:0004896	cytokine receptor activity(GO:0004896)
0.0	2.2	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	0.4	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0000703	oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703)
0.0	1.0	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	2.2	GO:0003777	microtubule motor activity(GO:0003777)
0.0	2.5	GO:0004702	receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0	0.6	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0	0.7	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.2	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.0	0.1	GO:0019870	potassium channel inhibitor activity(GO:0019870) sodium channel inhibitor activity(GO:0019871)
0.0	1.7	GO:0016503	pheromone receptor activity(GO:0016503)
0.0	1.4	GO:0008201	heparin binding(GO:0008201)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.0	23.7	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
1.9	34.7	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.8	29.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
1.7	36.6	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
1.2	73.9	PID AP1 PATHWAY	AP-1 transcription factor network
1.1	47.0	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
1.1	24.9	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
1.0	65.5	PID RAC1 PATHWAY	RAC1 signaling pathway
1.0	9.7	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.9	8.9	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.9	20.0	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.9	23.1	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.9	36.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.8	25.5	PID ALK1 PATHWAY	ALK1 signaling events
0.8	41.6	PID LKB1 PATHWAY	LKB1 signaling events
0.8	18.9	PID MYC PATHWAY	C-MYC pathway
0.8	30.8	PID ATR PATHWAY	ATR signaling pathway
0.7	16.8	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.7	33.7	PID IL12 2PATHWAY	IL12-mediated signaling events
0.7	11.8	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.7	14.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.7	5.2	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.6	143.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6	15.7	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.5	14.7	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.5	17.6	PID ILK PATHWAY	Integrin-linked kinase signaling
0.5	6.8	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.4	7.0	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.4	16.0	PID P53 REGULATION PATHWAY	p53 pathway
0.4	1.6	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.4	11.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4	9.0	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.4	19.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.4	8.9	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.3	34.3	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.3	6.0	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.3	4.3	PID IL1 PATHWAY	IL1-mediated signaling events
0.3	9.3	PID P73PATHWAY	p73 transcription factor network
0.3	10.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.3	11.1	PID BMP PATHWAY	BMP receptor signaling
0.3	12.3	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.2	2.4	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.2	4.2	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.2	16.7	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.2	2.6	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.2	6.1	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2	5.2	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.2	1.9	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.2	1.9	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	2.7	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	3.7	PID ATM PATHWAY	ATM pathway
0.2	2.6	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.2	9.3	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.2	26.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	1.1	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.2	1.5	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.2	2.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.2	1.6	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	7.2	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	3.8	PID ENDOTHELIN PATHWAY	Endothelins
0.1	4.7	PID NOTCH PATHWAY	Notch signaling pathway
0.1	1.3	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.1	5.0	PID AURORA B PATHWAY	Aurora B signaling
0.1	2.8	PID INSULIN PATHWAY	Insulin Pathway
0.1	2.2	PID ERBB4 PATHWAY	ErbB4 signaling events
0.1	1.7	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	0.9	ST G ALPHA I PATHWAY	G alpha i Pathway
0.1	1.0	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.1	1.7	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	1.1	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	0.1	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.8	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.0	5.2	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0	0.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	0.2	PID RHOA PATHWAY	RhoA signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.4	59.6	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
5.4	209.5	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
3.2	31.9	REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
2.7	26.8	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
2.4	24.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
2.3	35.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
2.2	40.9	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
2.1	27.4	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
2.0	46.8	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
1.9	11.4	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
1.7	103.7	REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	Genes involved in trans-Golgi Network Vesicle Budding
1.7	29.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
1.7	18.6	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
1.7	21.6	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
1.6	14.5	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
1.6	23.5	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
1.6	21.8	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
1.5	27.3	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
1.5	22.5	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
1.5	20.9	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
1.3	22.5	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
1.3	37.3	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
1.2	17.6	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.2	18.5	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
1.1	14.7	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
1.1	8.9	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
1.1	12.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
1.1	30.2	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
1.1	18.3	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.1	12.8	REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
1.1	20.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
1.0	9.9	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
1.0	4.9	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
1.0	9.5	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.9	19.0	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.9	6.4	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.9	34.2	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.9	12.4	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.8	31.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.8	9.4	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.8	11.0	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.8	13.3	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.8	29.0	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.8	22.1	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.8	4.6	REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	Genes involved in p53-Independent G1/S DNA damage checkpoint
0.7	87.2	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.6	6.4	REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.6	7.6	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.6	61.3	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.6	7.9	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.5	5.3	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.5	5.3	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.5	25.8	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.5	5.8	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.5	4.1	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.5	11.5	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.5	4.3	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.4	3.5	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.4	8.7	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.4	4.8	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.4	12.8	REACTOME KINESINS	Genes involved in Kinesins
0.4	62.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.4	3.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.4	5.1	REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	Genes involved in Activation of Kainate Receptors upon glutamate binding
0.4	17.5	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.4	3.7	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.4	4.3	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.4	5.3	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.4	26.1	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.4	6.0	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.3	4.0	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.3	5.9	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.3	13.6	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.3	2.9	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.3	6.1	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.3	3.4	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3	1.1	REACTOME HOST INTERACTIONS OF HIV FACTORS	Genes involved in Host Interactions of HIV factors
0.3	9.6	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.3	2.9	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.3	2.9	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.2	4.2	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.2	2.5	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2	8.0	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.2	9.7	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2	8.9	REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.2	3.0	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.2	7.7	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.2	6.8	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2	2.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2	10.1	REACTOME ASPARAGINE N LINKED GLYCOSYLATION	Genes involved in Asparagine N-linked glycosylation
0.2	3.6	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2	11.9	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.2	1.9	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	1.5	REACTOME SIGNALLING TO RAS	Genes involved in Signalling to RAS
0.2	9.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	28.6	REACTOME METABOLISM OF CARBOHYDRATES	Genes involved in Metabolism of carbohydrates
0.2	11.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.2	1.2	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2	7.5	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.2	9.3	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism
0.2	16.4	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.1	3.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	1.7	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	7.9	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	2.9	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	1.7	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	5.3	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	3.0	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	7.0	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.1	2.5	REACTOME G2 M CHECKPOINTS	Genes involved in G2/M Checkpoints
0.1	1.0	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1	3.3	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.1	2.1	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	1.0	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1	6.2	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	1.1	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	1.2	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.1	0.9	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.1	1.6	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	2.7	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.1	0.3	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	1.4	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	1.4	REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS	Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0	1.7	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	0.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Results for Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.15

Motif logo

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Activity-expression correlation:

Activity profile of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Sorted Z-values of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: