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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Thrb

Z-value: 0.69

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Transcription factors associated with Thrb

Gene Symbol Gene ID Gene Info
Thrb
ENSRNOG00000006649 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Thrbrn6_v1_chr15_-_8914501_8914501-0.482.0e-19Click!

Activity profile of Thrb motif

Sorted Z-values of Thrb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_30276372 39.72 ENSRNOT00000011823
Pon1
paraoxonase 1
chr1_-_170431073 33.77 ENSRNOT00000024710
Hpx
hemopexin
chr15_+_57290849 28.08 ENSRNOT00000014909
Cpb2
carboxypeptidase B2
chr16_+_74865516 19.44 ENSRNOT00000058072
Atp7b
ATPase copper transporting beta
chr6_+_139486775 17.96 ENSRNOT00000077771
AABR07065699.3

chr5_+_133865331 16.55 ENSRNOT00000035409
Tal1
TAL bHLH transcription factor 1, erythroid differentiation factor
chr3_-_6626284 15.94 ENSRNOT00000012494
Fcnb
ficolin B
chr1_+_201660042 14.11 ENSRNOT00000093289
ENSRNOT00000054910
Dmbt1
deleted in malignant brain tumors 1
chr4_+_102147211 13.62 ENSRNOT00000083239
AABR07060980.1

chr7_+_118712035 13.33 ENSRNOT00000074245
LOC100911562
apolipoprotein L3-like
chr1_+_88875375 13.23 ENSRNOT00000028284
Tyrobp
Tyro protein tyrosine kinase binding protein
chr20_-_5123073 12.55 ENSRNOT00000001126
Apom
apolipoprotein M
chr17_+_81352700 12.43 ENSRNOT00000024736
Mrc1
mannose receptor, C type 1
chr10_-_56962161 11.71 ENSRNOT00000026038
Alox15
arachidonate 15-lipoxygenase
chr1_+_219144205 11.62 ENSRNOT00000083942
Unc93b1
unc-93 homolog B1 (C. elegans)
chr5_+_34040258 11.15 ENSRNOT00000009758
Ggh
gamma-glutamyl hydrolase
chr3_-_4055806 11.15 ENSRNOT00000026408
Agpat2
1-acylglycerol-3-phosphate O-acyltransferase 2
chr9_+_14513037 9.94 ENSRNOT00000073130
Tspo2
translocator protein 2
chr4_-_157252565 9.83 ENSRNOT00000079947
Ptpn6
protein tyrosine phosphatase, non-receptor type 6
chr4_-_157252104 9.56 ENSRNOT00000082739
Ptpn6
protein tyrosine phosphatase, non-receptor type 6
chr3_+_148438939 7.64 ENSRNOT00000064196
Ttll9
tubulin tyrosine ligase like 9
chr2_-_88135410 7.62 ENSRNOT00000014180
Car3
carbonic anhydrase 3
chr8_+_122789453 7.35 ENSRNOT00000014585
Cmtm6
CKLF-like MARVEL transmembrane domain containing 6
chr3_-_82368357 7.02 ENSRNOT00000000052
Cd82
Cd82 molecule
chr2_+_127686925 6.18 ENSRNOT00000086653
ENSRNOT00000016946
Plk4
polo-like kinase 4
chr11_+_85633243 6.02 ENSRNOT00000045807
LOC682352
Ig lambda chain V-VI region AR-like
chr20_-_2103864 5.89 ENSRNOT00000001014
Rnf39
ring finger protein 39
chr10_+_31508512 5.81 ENSRNOT00000031580
Fam71b
family with sequence similarity 71, member B
chr13_+_50977431 5.72 ENSRNOT00000035658
Chit1
chitinase 1
chr8_+_128027958 5.47 ENSRNOT00000045049
Acaa1b
acetyl-Coenzyme A acyltransferase 1B
chr17_-_90522091 5.40 ENSRNOT00000077767
Lyst
lysosomal trafficking regulator
chr13_+_93751759 5.35 ENSRNOT00000065706
Wdr64
WD repeat domain 64
chr5_-_19559244 5.19 ENSRNOT00000014289
ENSRNOT00000089666
Nsmaf
neutral sphingomyelinase activation associated factor
chr3_+_81294275 5.11 ENSRNOT00000009068
RGD1563263
similar to RIKEN cDNA 1700029I15
chr10_+_108387789 4.99 ENSRNOT00000084845
AABR07030901.1

chr2_-_210703265 4.87 ENSRNOT00000080228
Gstm6l
glutathione S-transferase, mu 6-like
chr9_+_17728816 4.58 ENSRNOT00000065754
Capn11
calpain 11
chr4_+_174181644 4.57 ENSRNOT00000011555
Capza3
capping actin protein of muscle Z-line alpha subunit 3
chr10_+_92245442 4.26 ENSRNOT00000006808
Sppl2c
signal peptide peptidase like 2C
chr16_-_10706073 4.23 ENSRNOT00000089114
Fam25a
family with sequence similarity 25, member A
chr8_+_112594691 3.86 ENSRNOT00000038383
ENSRNOT00000081281
Acad11
acyl-CoA dehydrogenase family, member 11
chr5_+_156668712 3.82 ENSRNOT00000067228
Ddost
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
chr14_-_81053905 3.73 ENSRNOT00000045068
ENSRNOT00000040215
Rgs12
regulator of G-protein signaling 12
chr8_+_2635851 3.65 ENSRNOT00000061973
Casp4
caspase 4
chr14_+_43694183 3.58 ENSRNOT00000046342
RGD1563570
similar to ribosomal protein S23
chr9_+_94310921 3.04 ENSRNOT00000026646
Eif4e2
eukaryotic translation initiation factor 4E family member 2
chr17_+_45175121 2.89 ENSRNOT00000080417
Nkapl
NFKB activating protein-like
chr16_-_21473808 2.86 ENSRNOT00000066776
Zfp964
zinc finger protein 964
chr5_-_151117042 2.74 ENSRNOT00000066549
Fam76a
family with sequence similarity 76, member A
chr10_+_49368314 2.69 ENSRNOT00000004392
Cdrt4
CMT1A duplicated region transcript 4
chrX_+_124268129 2.53 ENSRNOT00000035489
Rhox13
Reproductive homeobox 13
chrX_-_61151601 2.47 ENSRNOT00000004132
Mageb4
melanoma antigen family B, 4
chr7_+_141053876 2.47 ENSRNOT00000084674
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr4_+_52147641 2.45 ENSRNOT00000009458
Hyal4
hyaluronoglucosaminidase 4
chr12_+_50315933 2.31 ENSRNOT00000000826
Srrd
SRR1 domain containing
chr5_-_159371313 2.24 ENSRNOT00000009921
Padi1
peptidyl arginine deiminase 1
chr17_-_22678253 2.07 ENSRNOT00000083122
LOC100362172
LRRGT00112-like
chr3_-_7051953 2.03 ENSRNOT00000013473
RGD1306233
similar to hypothetical protein MGC29761
chr4_+_72221550 1.80 ENSRNOT00000078533
Olr806
olfactory receptor 806
chr4_-_56786754 1.70 ENSRNOT00000050795
Kcp
kielin/chordin-like protein
chr9_+_94310469 1.61 ENSRNOT00000065743
Eif4e2
eukaryotic translation initiation factor 4E family member 2
chrX_-_102039530 1.54 ENSRNOT00000085348
AABR07040480.1

chr3_-_119405453 1.49 ENSRNOT00000090355
Sppl2a
signal peptide peptidase-like 2A
chr10_-_110431792 1.13 ENSRNOT00000054922
LOC619574
hypothetical protein LOC619574
chr13_+_109909053 0.89 ENSRNOT00000090541
AC125873.1

chr15_-_27499998 0.79 ENSRNOT00000050189
LOC103693822
olfactory receptor 11H4-like
chr8_-_115358046 0.68 ENSRNOT00000017607
Grm2
glutamate metabotropic receptor 2
chr13_+_91768256 0.64 ENSRNOT00000071206
LOC681470
similar to olfactory receptor 1403
chr15_-_27485639 0.61 ENSRNOT00000041030
Olr1631
olfactory receptor 1631
chr10_-_76263866 0.43 ENSRNOT00000003219
Scpep1
serine carboxypeptidase 1
chr1_-_73733788 0.42 ENSRNOT00000025338
Leng8
leukocyte receptor cluster member 8
chr10_-_12386222 0.42 ENSRNOT00000060994
Olr1364
olfactory receptor 1364
chr8_+_115131367 0.41 ENSRNOT00000014849
Rpl29
ribosomal protein L29
chr7_-_144960527 0.36 ENSRNOT00000086554
Zfp385a
zinc finger protein 385A
chr3_-_20853708 0.35 ENSRNOT00000010360
Olr411
olfactory receptor 411
chr15_-_27549748 0.35 ENSRNOT00000040096
Olr1635
olfactory receptor 1635
chr10_-_44082313 0.34 ENSRNOT00000051126
Olr1421
olfactory receptor 1421
chr8_-_111107599 0.30 ENSRNOT00000031313
Cep63
centrosomal protein 63
chr3_-_160922341 0.21 ENSRNOT00000029206
Tp53tg5
TP53 target 5
chr10_+_44933574 0.09 ENSRNOT00000072854
LOC103690280
olfactory receptor 2AK2-like
chr10_+_44958544 0.01 ENSRNOT00000072282
Olr1439
olfactory receptor 1439

Network of associatons between targets according to the STRING database.

First level regulatory network of Thrb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
17.4 52.3 GO:0034445 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
9.4 28.1 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
8.4 33.8 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
6.5 19.4 GO:0015680 intracellular copper ion transport(GO:0015680)
5.5 16.6 GO:0045799 positive regulation of chromatin assembly or disassembly(GO:0045799)
4.8 19.4 GO:0033277 abortive mitotic cell cycle(GO:0033277)
4.0 15.9 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
2.7 5.4 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
2.3 11.7 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
2.1 6.2 GO:0046601 positive regulation of centriole replication(GO:0046601)
1.7 11.6 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154) positive regulation of interleukin-12 secretion(GO:2001184)
1.5 13.2 GO:2001204 regulation of osteoclast development(GO:2001204)
1.1 5.7 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.8 2.5 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.8 11.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.7 14.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.6 3.7 GO:0023021 termination of signal transduction(GO:0023021)
0.5 5.8 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.5 3.7 GO:0070269 pyroptosis(GO:0070269)
0.4 2.2 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.4 11.2 GO:0006541 glutamine metabolic process(GO:0006541)
0.4 3.9 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.3 12.4 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.2 7.6 GO:0006730 one-carbon metabolic process(GO:0006730)
0.2 4.6 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.2 2.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 2.5 GO:0006026 aminoglycan catabolic process(GO:0006026)
0.1 3.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.4 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 0.7 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1 5.9 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 0.3 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 1.7 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 4.6 GO:0006413 translational initiation(GO:0006413)
0.0 11.2 GO:0006869 lipid transport(GO:0006869)
0.0 0.4 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.0 5.5 GO:0006631 fatty acid metabolic process(GO:0006631)
0.0 2.9 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.4 GO:0002181 cytoplasmic translation(GO:0002181)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 52.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
2.4 19.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.3 15.9 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
1.2 6.2 GO:0098536 deuterosome(GO:0098536)
1.1 11.6 GO:0032009 early phagosome(GO:0032009)
0.8 5.8 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.7 14.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.7 3.7 GO:0072557 IPAF inflammasome complex(GO:0072557) NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169)
0.7 19.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.5 4.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.3 33.8 GO:0072562 blood microparticle(GO:0072562)
0.3 4.6 GO:0005845 mRNA cap binding complex(GO:0005845)
0.2 3.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 16.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 2.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.2 11.7 GO:0005811 lipid particle(GO:0005811)
0.1 3.7 GO:0097440 apical dendrite(GO:0097440)
0.1 11.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 8.6 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 12.4 GO:0010008 endosome membrane(GO:0010008)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 4.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 34.5 GO:0005615 extracellular space(GO:0005615)
0.0 15.7 GO:0009986 cell surface(GO:0009986)
0.0 5.4 GO:0005874 microtubule(GO:0005874)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
13.2 39.7 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
3.9 19.4 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
3.8 33.8 GO:0015232 heme transporter activity(GO:0015232)
2.9 11.7 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
2.2 19.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
2.0 14.1 GO:0035375 zymogen binding(GO:0035375)
1.7 5.2 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
1.3 3.9 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
1.1 15.9 GO:0033691 sialic acid binding(GO:0033691)
1.0 28.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.0 11.2 GO:0008242 omega peptidase activity(GO:0008242)
1.0 7.6 GO:0016151 nickel cation binding(GO:0016151)
1.0 5.7 GO:0004568 chitinase activity(GO:0004568)
0.9 11.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.8 11.6 GO:0035325 Toll-like receptor binding(GO:0035325)
0.8 5.5 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.6 12.4 GO:0005537 mannose binding(GO:0005537)
0.6 2.5 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.4 2.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.3 16.6 GO:0070888 E-box binding(GO:0070888)
0.3 3.7 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.3 3.8 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 2.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 1.5 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.2 2.5 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.2 0.7 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.2 4.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 7.8 GO:0015485 cholesterol binding(GO:0015485)
0.1 4.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 12.6 GO:0005319 lipid transporter activity(GO:0005319)
0.1 0.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 3.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 4.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 13.2 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 1.7 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.0 7.6 GO:0016874 ligase activity(GO:0016874)
0.0 13.3 GO:0008289 lipid binding(GO:0008289)
0.0 4.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 19.4 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.2 11.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 21.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.2 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 7.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 15.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 32.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.9 11.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.3 11.1 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.3 3.8 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 3.7 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 6.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 4.6 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 2.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 2.8 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events