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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Vsx2_Dlx3

Z-value: 0.98

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Transcription factors associated with Vsx2_Dlx3

Gene Symbol Gene ID Gene Info
Vsx2
ENSRNOG00000011918 visual system homeobox 2
Dlx3
ENSRNOG00000004278 distal-less homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Dlx3rn6_v1_chr10_+_82937971_829379710.331.1e-09Click!
Vsx2rn6_v1_chr6_+_108285822_1082858220.304.2e-08Click!

Activity profile of Vsx2_Dlx3 motif

Sorted Z-values of Vsx2_Dlx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_43638161 58.76 ENSRNOT00000024460
Ipcef1
interaction protein for cytohesin exchange factors 1
chr1_+_59156251 56.59 ENSRNOT00000017442
Lix1
limb and CNS expressed 1
chr13_-_76049363 46.96 ENSRNOT00000075865
ENSRNOT00000007455
Brinp2
BMP/retinoic acid inducible neural specific 2
chr2_-_219262901 44.17 ENSRNOT00000037068
Gpr88
G-protein coupled receptor 88
chr14_+_39964588 36.97 ENSRNOT00000003240
Gabrg1
gamma-aminobutyric acid type A receptor gamma 1 subunit
chr10_-_87248572 35.18 ENSRNOT00000066637
ENSRNOT00000085677
Krt26
keratin 26
chr6_+_48452369 33.16 ENSRNOT00000044310
Myt1l
myelin transcription factor 1-like
chr4_-_55011415 32.08 ENSRNOT00000056996
Grm8
glutamate metabotropic receptor 8
chr9_-_85243001 30.82 ENSRNOT00000020219
Scg2
secretogranin II
chr4_-_4473307 30.45 ENSRNOT00000045773
Dpp6
dipeptidyl peptidase like 6
chr4_+_108301129 29.65 ENSRNOT00000007993
LRRTM1
leucine rich repeat transmembrane neuronal 1
chr12_-_2174131 28.84 ENSRNOT00000001313
Pcp2
Purkinje cell protein 2
chr13_+_31081804 27.38 ENSRNOT00000041413
Cdh7
cadherin 7
chr1_+_198383201 25.26 ENSRNOT00000037405
Sez6l2
seizure related 6 homolog like 2
chr5_-_17061837 24.89 ENSRNOT00000011892
Penk
proenkephalin
chr3_-_66417741 24.87 ENSRNOT00000007662
Neurod1
neuronal differentiation 1
chr12_-_35979193 24.05 ENSRNOT00000071104
Tmem132b
transmembrane protein 132B
chr4_+_94696965 23.73 ENSRNOT00000064696
Grid2
glutamate ionotropic receptor delta type subunit 2
chr12_-_10335499 23.43 ENSRNOT00000071567
Wasf3
WAS protein family, member 3
chr5_-_17061361 22.48 ENSRNOT00000089318
Penk
proenkephalin
chr18_+_81821127 22.42 ENSRNOT00000058199
Fbxo15
F-box protein 15
chr16_-_73152921 22.13 ENSRNOT00000048602
Zmat4
zinc finger, matrin type 4
chr2_-_139528162 21.44 ENSRNOT00000014317
Slc7a11
solute carrier family 7 member 11
chr3_+_48106099 21.12 ENSRNOT00000007218
Slc4a10
solute carrier family 4 member 10
chr11_+_58624198 20.44 ENSRNOT00000002091
Gap43
growth associated protein 43
chr11_+_69739384 20.34 ENSRNOT00000016340
Kalrn
kalirin, RhoGEF kinase
chr7_-_52404774 19.69 ENSRNOT00000082100
Nav3
neuron navigator 3
chr18_-_26211445 19.03 ENSRNOT00000027739
Nrep
neuronal regeneration related protein
chr2_-_173087648 18.93 ENSRNOT00000091079
Iqcj
IQ motif containing J
chr5_-_130085838 18.90 ENSRNOT00000035252
Elavl4
ELAV like RNA binding protein 4
chr12_-_19167015 18.83 ENSRNOT00000001797
Gjc3
gap junction protein, gamma 3
chr7_-_76488216 18.82 ENSRNOT00000080024
Ncald
neurocalcin delta
chr12_-_17186679 18.80 ENSRNOT00000001730
Uncx
UNC homeobox
chr2_-_179704629 17.51 ENSRNOT00000083361
ENSRNOT00000077941
Gria2
glutamate ionotropic receptor AMPA type subunit 2
chr15_+_1054937 16.29 ENSRNOT00000008154
AABR07016841.1

chr4_-_17594598 15.59 ENSRNOT00000008936
Sema3e
semaphorin 3E
chr4_-_135069970 15.23 ENSRNOT00000008221
Cntn3
contactin 3
chr13_+_71107465 15.02 ENSRNOT00000003239
Rgs8
regulator of G-protein signaling 8
chr7_+_78558701 14.71 ENSRNOT00000006393
Rims2
regulating synaptic membrane exocytosis 2
chr1_-_215033460 14.26 ENSRNOT00000044565
Dusp8
dual specificity phosphatase 8
chr10_-_66848388 13.98 ENSRNOT00000018891
Omg
oligodendrocyte-myelin glycoprotein
chr14_-_21128505 13.87 ENSRNOT00000004776
Rufy3
RUN and FYVE domain containing 3
chr18_-_12640716 13.78 ENSRNOT00000020697
Klhl14
kelch-like family member 14
chr3_+_95715193 13.31 ENSRNOT00000089525
Pax6
paired box 6
chr6_-_108660063 12.69 ENSRNOT00000006240
Arel1
apoptosis resistant E3 ubiquitin protein ligase 1
chr3_+_54253949 12.04 ENSRNOT00000010018
B3galt1
Beta-1,3-galactosyltransferase 1
chr20_+_29655226 11.95 ENSRNOT00000089059
Spock2
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
chr8_+_33239139 10.50 ENSRNOT00000011589
Arhgap32
Rho GTPase activating protein 32
chr6_+_58468155 10.38 ENSRNOT00000091263
Etv1
ets variant 1
chr15_+_12827707 10.17 ENSRNOT00000012452
Fezf2
Fez family zinc finger 2
chr19_+_25043680 9.95 ENSRNOT00000043971
Adgrl1
adhesion G protein-coupled receptor L1
chr8_-_128754514 9.76 ENSRNOT00000025019
Cx3cr1
C-X3-C motif chemokine receptor 1
chr7_-_143353925 9.29 ENSRNOT00000068533
Krt71
keratin 71
chr7_-_142348232 8.82 ENSRNOT00000078848
Galnt6
polypeptide N-acetylgalactosaminyltransferase 6
chr4_-_117575154 8.71 ENSRNOT00000075813
LOC102556148
probable N-acetyltransferase CML2-like
chr13_-_95250235 8.55 ENSRNOT00000085648
Akt3
AKT serine/threonine kinase 3
chr5_+_61474000 8.47 ENSRNOT00000013930
Ccdc180
coiled-coil domain containing 180
chr12_+_18679789 7.84 ENSRNOT00000001863
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
chr20_-_27578244 6.97 ENSRNOT00000000708
Fam26d
family with sequence similarity 26, member D
chr7_-_145062956 6.60 ENSRNOT00000055274
RGD1563200
similar to CDNA sequence BC048502
chr4_-_150485781 6.40 ENSRNOT00000008763
Zfp248
zinc finger protein 248
chr1_+_217345545 6.38 ENSRNOT00000071741
Shank2
SH3 and multiple ankyrin repeat domains 2
chr5_-_32956159 6.33 ENSRNOT00000078264
Cnbd1
cyclic nucleotide binding domain containing 1
chr9_+_66058047 6.25 ENSRNOT00000071819
Cdk15
cyclin-dependent kinase 15
chr6_+_132510757 5.97 ENSRNOT00000080230
Evl
Enah/Vasp-like
chr10_+_90230711 5.61 ENSRNOT00000055185
Tmub2
transmembrane and ubiquitin-like domain containing 2
chr5_-_28131133 5.50 ENSRNOT00000067331
Slc26a7
solute carrier family 26 member 7
chr13_+_70157522 5.23 ENSRNOT00000036906
Apobec4
apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
chrX_+_131381134 5.18 ENSRNOT00000007474
AABR07041481.1

chr5_-_28130803 4.88 ENSRNOT00000093186
Slc26a7
solute carrier family 26 member 7
chr7_+_83348694 4.30 ENSRNOT00000006402
Eny2
ENY2, transcription and export complex 2 subunit
chr7_-_83348487 4.02 ENSRNOT00000006685
Nudcd1
NudC domain containing 1
chr9_-_81566096 3.93 ENSRNOT00000019497
Aamp
angio-associated, migratory cell protein
chr14_-_6793558 3.82 ENSRNOT00000002927
Mepe
matrix extracellular phosphoglycoprotein
chr4_-_50312608 3.76 ENSRNOT00000010019
Fezf1
Fez family zinc finger 1
chr2_-_113616766 3.68 ENSRNOT00000016858
ENSRNOT00000074723
Tmem212
transmembrane protein 212
chr18_+_51523758 3.61 ENSRNOT00000078518
Gramd3
GRAM domain containing 3
chr9_+_71915421 3.58 ENSRNOT00000020447
Pikfyve
phosphoinositide kinase, FYVE-type zinc finger containing
chr17_-_45746753 3.45 ENSRNOT00000077475
RGD1564243
similar to brain Zn-finger protein
chr3_+_47578384 3.36 ENSRNOT00000082769
Psmd14
proteasome 26S subunit, non-ATPase 14
chr2_+_145174876 3.28 ENSRNOT00000040631
Mab21l1
mab-21 like 1
chr11_-_46693565 3.24 ENSRNOT00000044900
Impg2
interphotoreceptor matrix proteoglycan 2
chr13_+_98311827 3.10 ENSRNOT00000082844
Cdc42bpa
CDC42 binding protein kinase alpha
chr18_-_69780922 3.07 ENSRNOT00000079093
Me2
malic enzyme 2
chr13_-_100672731 2.92 ENSRNOT00000004319
Degs1
delta(4)-desaturase, sphingolipid 1
chr18_+_66741144 2.92 ENSRNOT00000021161
AABR07032457.1

chr19_-_17399548 2.86 ENSRNOT00000075991
Chd9
chromodomain helicase DNA binding protein 9
chr9_-_81566642 2.85 ENSRNOT00000080345
Aamp
angio-associated, migratory cell protein
chr1_-_279277339 2.82 ENSRNOT00000023667
Gfra1
GDNF family receptor alpha 1
chr1_+_279633671 2.76 ENSRNOT00000036012
ENSRNOT00000091669
Ccdc172
coiled-coil domain containing 172
chr10_+_82032656 2.56 ENSRNOT00000067751
Ankrd40
ankyrin repeat domain 40
chr4_+_31333970 2.50 ENSRNOT00000064866
LOC100911994
coiled-coil domain-containing protein 132-like
chr9_-_65736852 2.43 ENSRNOT00000087458
Trak2
trafficking kinesin protein 2
chr7_-_122581777 2.40 ENSRNOT00000025758
Slc25a17
solute carrier family 25 member 17
chr1_-_124803363 2.29 ENSRNOT00000066380
Klf13
Kruppel-like factor 13
chr5_-_66322567 2.25 ENSRNOT00000032726
Cylc2
cylicin 2
chr16_-_6404578 2.24 ENSRNOT00000051371
Cacna1d
calcium voltage-gated channel subunit alpha1 D
chr2_+_226563050 2.12 ENSRNOT00000065111
Bcar3
breast cancer anti-estrogen resistance 3
chr10_+_91217079 2.05 ENSRNOT00000004218
Hexim2
hexamethylene bis-acetamide inducible 2
chr3_+_18787606 1.94 ENSRNOT00000090508
AABR07051658.1

chr16_-_6404957 1.91 ENSRNOT00000048459
Cacna1d
calcium voltage-gated channel subunit alpha1 D
chr8_+_107229832 1.90 ENSRNOT00000045821
Faim
Fas apoptotic inhibitory molecule
chr18_-_61672663 1.82 ENSRNOT00000022718
Cplx4
complexin 4
chrX_+_136466779 1.66 ENSRNOT00000093268
ENSRNOT00000068717
Arhgap36
Rho GTPase activating protein 36
chr9_-_38495126 1.65 ENSRNOT00000016933
ENSRNOT00000090385
Rab23
RAB23, member RAS oncogene family
chr4_+_88119838 1.60 ENSRNOT00000073173
Vom1r82
vomeronasal 1 receptor 82
chr6_+_73358112 1.50 ENSRNOT00000041373
Arhgap5
Rho GTPase activating protein 5
chr9_-_65737538 1.38 ENSRNOT00000014939
Trak2
trafficking kinesin protein 2
chr10_+_29606748 1.37 ENSRNOT00000080720
AABR07029467.2

chr4_+_61924013 1.34 ENSRNOT00000090717
Bpgm
bisphosphoglycerate mutase
chr4_+_2053712 1.33 ENSRNOT00000045086
Rnf32
ring finger protein 32
chr20_-_11626876 1.32 ENSRNOT00000001635
LOC100361664
keratin associated protein 12-1-like
chr4_+_6827429 1.29 ENSRNOT00000071737
Rheb
Ras homolog enriched in brain
chr12_+_46042413 1.27 ENSRNOT00000046882
Ccdc60
coiled-coil domain containing 60
chr7_+_71157664 1.12 ENSRNOT00000005919
Sdr9c7
short chain dehydrogenase/reductase family 9C, member 7
chr6_+_64252020 1.04 ENSRNOT00000047296
ENSRNOT00000082105
Pnpla8
patatin-like phospholipase domain containing 8
chr3_+_19045214 0.99 ENSRNOT00000070878
AABR07051670.1

chr1_+_98414226 0.93 ENSRNOT00000090785
Siglecl1
SIGLEC family like 1
chr7_-_143967484 0.89 ENSRNOT00000081758
Sp7
Sp7 transcription factor
chr2_-_33025271 0.82 ENSRNOT00000074941
NEWGENE_1310139
microtubule associated serine/threonine kinase family member 4
chr7_+_3173287 0.82 ENSRNOT00000092037
Pym1
PYM homolog 1, exon junction complex associated factor
chrX_+_78769419 0.72 ENSRNOT00000003190
Tbx22
T-box 22
chr17_-_78812111 0.67 ENSRNOT00000021506
Dclre1c
DNA cross-link repair 1C
chr3_-_57646572 0.66 ENSRNOT00000076202
Mettl8
methyltransferase like 8
chr8_-_39551700 0.63 ENSRNOT00000091894
ENSRNOT00000076025
Pknox2
PBX/knotted 1 homeobox 2
chr8_+_57983556 0.44 ENSRNOT00000009562
RGD1311251
similar to RIKEN cDNA 4930550C14
chr10_-_18131562 0.44 ENSRNOT00000006676
Tlx3
T-cell leukemia, homeobox 3
chr3_+_72134731 0.43 ENSRNOT00000083592
Ypel4
yippee-like 4
chr16_+_35934970 0.35 ENSRNOT00000084707
ENSRNOT00000016474
Galnt7
polypeptide N-acetylgalactosaminyltransferase 7
chr7_-_14364178 0.34 ENSRNOT00000090673
Akap8l
A-kinase anchoring protein 8 like
chr2_-_98610368 0.29 ENSRNOT00000011641
Zfhx4
zinc finger homeobox 4
chr8_+_81863619 0.20 ENSRNOT00000080608
Fam214a
family with sequence similarity 214, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of Vsx2_Dlx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.8 47.4 GO:0051867 general adaptation syndrome, behavioral process(GO:0051867)
8.8 44.2 GO:0061743 motor learning(GO:0061743)
5.0 24.9 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
4.4 13.3 GO:0021918 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
4.1 20.3 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
3.7 29.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
3.6 28.8 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
3.5 13.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.9 32.1 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
2.4 9.8 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
2.3 18.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
2.1 30.8 GO:0048245 eosinophil chemotaxis(GO:0048245)
2.0 20.4 GO:0016198 axon choice point recognition(GO:0016198)
2.0 7.8 GO:0009822 lipid hydroxylation(GO:0002933) alkaloid catabolic process(GO:0009822)
1.7 23.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.5 11.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.4 46.8 GO:0097352 autophagosome maturation(GO:0097352)
1.3 25.3 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
1.3 3.8 GO:0098939 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
1.3 21.4 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
1.2 23.4 GO:0031643 positive regulation of myelination(GO:0031643)
1.2 21.1 GO:0021860 pyramidal neuron development(GO:0021860)
1.2 15.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
1.1 14.7 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.9 10.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.9 12.0 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.8 2.4 GO:0043132 NAD transport(GO:0043132)
0.8 32.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.7 17.5 GO:0060992 response to fungicide(GO:0060992)
0.7 30.5 GO:1901381 positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of potassium ion transmembrane transport(GO:1901381)
0.6 9.9 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.6 8.6 GO:0045793 positive regulation of cell size(GO:0045793)
0.6 10.4 GO:0019532 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.6 4.1 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.6 13.9 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.6 47.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.5 33.0 GO:0031103 axon regeneration(GO:0031103)
0.5 6.4 GO:0099562 maintenance of postsynaptic specialization structure(GO:0098880) maintenance of postsynaptic density structure(GO:0099562)
0.5 15.6 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.4 4.4 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.4 9.3 GO:0045109 intermediate filament organization(GO:0045109)
0.3 4.3 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.3 18.9 GO:0042220 response to cocaine(GO:0042220)
0.3 1.0 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.2 3.1 GO:0007097 nuclear migration(GO:0007097)
0.2 3.8 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.2 22.4 GO:0042552 myelination(GO:0042552)
0.2 2.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.2 1.3 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714) regulation of type B pancreatic cell development(GO:2000074)
0.1 6.0 GO:0045010 actin nucleation(GO:0045010)
0.1 3.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 1.6 GO:0006968 cellular defense response(GO:0006968)
0.1 3.4 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 0.3 GO:0030397 membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.1 2.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 10.6 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 2.0 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.1 6.8 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 12.7 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.1 0.7 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 1.9 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1 8.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 19.1 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161)
0.0 0.9 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 9.2 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 1.5 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.0 0.4 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 3.2 GO:0007601 visual perception(GO:0007601)
0.0 2.9 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 2.8 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.0 0.8 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 7.2 GO:0016337 single organismal cell-cell adhesion(GO:0016337)
0.0 5.1 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.5 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 5.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.9 47.4 GO:0032280 symmetric synapse(GO:0032280)
3.5 21.1 GO:0097441 basilar dendrite(GO:0097441)
2.6 20.4 GO:0032584 growth cone membrane(GO:0032584)
1.9 30.8 GO:0031045 dense core granule(GO:0031045)
1.9 18.9 GO:0042788 polysomal ribosome(GO:0042788)
1.5 17.5 GO:0098839 postsynaptic density membrane(GO:0098839)
1.1 3.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.8 16.2 GO:0005922 connexon complex(GO:0005922)
0.7 13.9 GO:0071437 invadopodium(GO:0071437)
0.7 24.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.6 37.0 GO:0034707 chloride channel complex(GO:0034707)
0.6 30.1 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.6 56.7 GO:0042734 presynaptic membrane(GO:0042734)
0.4 4.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.4 3.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.3 15.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 30.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 4.3 GO:0000124 SAGA complex(GO:0000124)
0.3 15.1 GO:0016235 aggresome(GO:0016235)
0.3 22.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 3.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 6.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 29.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 21.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 120.6 GO:0043025 neuronal cell body(GO:0043025)
0.2 23.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 28.5 GO:0030027 lamellipodium(GO:0030027)
0.1 2.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.7 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 10.5 GO:0001650 fibrillar center(GO:0001650)
0.1 3.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 10.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 19.7 GO:0005635 nuclear envelope(GO:0005635)
0.0 16.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 8.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 2.0 GO:0042641 actomyosin(GO:0042641)
0.0 3.0 GO:0005882 intermediate filament(GO:0005882)
0.0 1.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.6 GO:0045171 intercellular bridge(GO:0045171)
0.0 59.0 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 32.1 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
7.9 47.4 GO:0001515 opioid peptide activity(GO:0001515)
7.1 21.4 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
5.1 20.4 GO:0035727 lysophosphatidic acid binding(GO:0035727)
4.1 33.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
3.5 17.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
3.0 30.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
2.4 12.0 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
2.4 40.8 GO:0050811 GABA receptor binding(GO:0050811)
2.0 9.8 GO:0019960 C-X3-C chemokine binding(GO:0019960)
1.3 13.3 GO:0003680 AT DNA binding(GO:0003680)
1.3 23.7 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
1.2 15.6 GO:0030215 semaphorin receptor binding(GO:0030215)
1.1 30.8 GO:0042056 chemoattractant activity(GO:0042056)
1.0 2.9 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.9 20.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.8 9.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.8 21.1 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.7 18.9 GO:0017091 AU-rich element binding(GO:0017091)
0.7 10.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.7 4.1 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
0.6 18.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.6 24.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.5 3.8 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.5 3.1 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.5 6.4 GO:0098919 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.5 2.4 GO:0051185 coenzyme transporter activity(GO:0051185)
0.5 3.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.4 3.6 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.3 1.3 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.3 6.0 GO:0005522 profilin binding(GO:0005522)
0.3 44.2 GO:0003774 motor activity(GO:0003774)
0.3 31.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.3 7.8 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.2 8.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 3.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 11.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 5.2 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 8.6 GO:0005080 protein kinase C binding(GO:0005080)
0.1 31.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 1.0 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.1 3.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.2 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.1 0.7 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 9.4 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 14.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 4.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 6.8 GO:0051082 unfolded protein binding(GO:0051082)
0.1 60.3 GO:0019904 protein domain specific binding(GO:0019904)
0.1 36.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 1.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 8.3 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 9.9 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.8 GO:0005178 integrin binding(GO:0005178)
0.0 1.3 GO:0019003 GDP binding(GO:0019003)
0.0 7.0 GO:0005261 cation channel activity(GO:0005261)
0.0 10.2 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.8 GO:0043022 ribosome binding(GO:0043022)
0.0 1.6 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 8.8 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 67.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
1.1 20.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.9 38.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.6 47.4 PID AP1 PATHWAY AP-1 transcription factor network
0.5 10.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.4 14.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 13.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.3 12.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.3 16.4 PID CDC42 PATHWAY CDC42 signaling events
0.1 9.0 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 2.8 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 32.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 15.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 1.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.7 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.3 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 46.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
1.5 32.1 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.2 18.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.0 27.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
1.0 17.5 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.9 15.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.8 21.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.3 34.3 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.3 57.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 6.0 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 9.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.3 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 1.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 2.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 8.7 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 3.4 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.1 2.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 7.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.0 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE