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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Xbp1_Creb3l1

Z-value: 1.16

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Transcription factors associated with Xbp1_Creb3l1

Gene Symbol Gene ID Gene Info
Xbp1
ENSRNOG00000010298 X-box binding protein 1
Creb3l1
ENSRNOG00000005413 cAMP responsive element binding protein 3-like 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Creb3l1rn6_v1_chr3_-_80933283_809332830.565.8e-28Click!
Xbp1rn6_v1_chr14_+_85753760_857537600.422.6e-15Click!

Activity profile of Xbp1_Creb3l1 motif

Sorted Z-values of Xbp1_Creb3l1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_101086198 52.35 ENSRNOT00000027917
Rcn3
reticulocalbin 3
chr1_-_101085884 49.81 ENSRNOT00000085352
Rcn3
reticulocalbin 3
chr2_+_227455722 46.48 ENSRNOT00000064809
Sec24d
SEC24 homolog D, COPII coat complex component
chr18_+_52423883 32.44 ENSRNOT00000022017
Prrc1
proline-rich coiled-coil 1
chr7_+_120749752 31.00 ENSRNOT00000087888
Kdelr3
KDEL endoplasmic reticulum protein retention receptor 3
chr4_+_56625561 29.46 ENSRNOT00000008356
ENSRNOT00000090808
ENSRNOT00000008972
Calu
calumenin
chr5_-_173081839 29.32 ENSRNOT00000066880
Mmp23
matrix metallopeptidase 23
chr18_-_47513030 28.00 ENSRNOT00000083881
ENSRNOT00000074226
Lox
lysyl oxidase
chr17_+_26925828 24.66 ENSRNOT00000018310
Txndc5
thioredoxin domain containing 5
chr13_+_80125391 21.64 ENSRNOT00000044190
Mir199a2
microRNA 199a-2
chr3_-_138116664 18.04 ENSRNOT00000055602
Rrbp1
ribosome binding protein 1
chr17_+_9736786 17.78 ENSRNOT00000081920
F12
coagulation factor XII
chr7_+_11490852 16.88 ENSRNOT00000044484
Creb3l3
cAMP responsive element binding protein 3-like 3
chr7_+_31784438 15.97 ENSRNOT00000010914
ENSRNOT00000010929
Ikbip
IKBKB interacting protein
chr4_+_119997268 15.81 ENSRNOT00000073429
Rpn1
ribophorin I
chr11_+_46009322 15.46 ENSRNOT00000002233
Tmem45a
transmembrane protein 45A
chr5_-_59025631 15.45 ENSRNOT00000049000
ENSRNOT00000022801
Tpm2
tropomyosin 2, beta
chr11_+_46714355 15.41 ENSRNOT00000073404
Tmem45al
transmembrane protein 45A-like
chr11_+_68493035 14.26 ENSRNOT00000067984
Pdia5
protein disulfide isomerase family A, member 5
chr9_-_100624638 14.13 ENSRNOT00000051155
Hdlbp
high density lipoprotein binding protein
chr6_+_53401109 13.99 ENSRNOT00000014763
Twist1
twist family bHLH transcription factor 1
chr5_+_167952728 13.39 ENSRNOT00000085315
Errfi1
ERBB receptor feedback inhibitor 1
chr1_+_251145253 12.78 ENSRNOT00000083555
ENSRNOT00000014979
Papss2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr3_+_95232166 12.24 ENSRNOT00000017952
LOC691083
hypothetical protein LOC691083
chr8_+_112594691 12.06 ENSRNOT00000038383
ENSRNOT00000081281
Acad11
acyl-CoA dehydrogenase family, member 11
chr1_-_226152524 11.93 ENSRNOT00000027756
Fads2
fatty acid desaturase 2
chr15_+_57891680 11.55 ENSRNOT00000001383
Tpt1
tumor protein, translationally-controlled 1
chr5_-_59063592 11.47 ENSRNOT00000022400
Tln1
talin 1
chr4_-_120467932 11.36 ENSRNOT00000018454
Sec61a1
Sec61 translocon alpha 1 subunit
chr5_+_76150840 11.33 ENSRNOT00000020702
Dnajc25
DnaJ heat shock protein family (Hsp40) member C25
chr17_+_30965942 11.20 ENSRNOT00000060143
Pxdc1
PX domain containing 1
chr1_-_185143272 11.14 ENSRNOT00000027752
Nucb2
nucleobindin 2
chr10_+_39435227 11.05 ENSRNOT00000042144
ENSRNOT00000077185
P4ha2
prolyl 4-hydroxylase subunit alpha 2
chr20_+_46250363 10.75 ENSRNOT00000076522
ENSRNOT00000000334
Cd164
CD164 molecule
chr5_+_5215196 10.50 ENSRNOT00000010481
Tram1
translocation associated membrane protein 1
chr1_+_220470089 9.80 ENSRNOT00000027406
ENSRNOT00000078657
Yif1a
Yip1 interacting factor homolog A, membrane trafficking protein
chr4_-_82258765 9.69 ENSRNOT00000008523
Hoxa5
homeo box A5
chr16_+_2338333 9.60 ENSRNOT00000017692
Arf4
ADP-ribosylation factor 4
chr1_+_101859346 9.26 ENSRNOT00000028627
Kdelr1
KDEL endoplasmic reticulum protein retention receptor 1
chr9_-_82699551 9.20 ENSRNOT00000020673
Obsl1
obscurin-like 1
chr20_-_3822754 8.95 ENSRNOT00000000541
ENSRNOT00000077357
Slc39a7
solute carrier family 39 member 7
chr8_-_97083120 8.78 ENSRNOT00000018603
Tmed3
transmembrane p24 trafficking protein 3
chr12_-_13210758 8.64 ENSRNOT00000001438
Kdelr2
KDEL endoplasmic reticulum protein retention receptor 2
chr5_+_63192298 8.48 ENSRNOT00000008329
Sec61b
Sec61 translocon beta subunit
chr5_-_58445953 8.31 ENSRNOT00000046102
Vcp
valosin-containing protein
chr4_-_84768249 8.21 ENSRNOT00000013205
Fkbp14
FK506 binding protein 14
chr1_+_199941161 7.85 ENSRNOT00000027616
Bag3
Bcl2-associated athanogene 3
chr4_+_55772377 7.75 ENSRNOT00000047698
Snd1
staphylococcal nuclease and tudor domain containing 1
chrX_-_156999650 7.55 ENSRNOT00000083557
Ssr4
signal sequence receptor subunit 4
chr8_-_13109487 7.43 ENSRNOT00000061616
Amotl1
angiomotin-like 1
chr7_+_24939498 7.18 ENSRNOT00000010601
Ckap4
cytoskeleton-associated protein 4
chr20_+_47494270 7.17 ENSRNOT00000036365
Sec63
SEC63 homolog, protein translocation regulator
chr20_+_47494424 7.10 ENSRNOT00000087718
Sec63
SEC63 homolog, protein translocation regulator
chr10_-_37209881 7.08 ENSRNOT00000090475
Sec24a
SEC24 homolog A, COPII coat complex component
chr9_-_100592271 7.05 ENSRNOT00000086433
Hdlbp
high density lipoprotein binding protein
chr1_+_225096598 6.74 ENSRNOT00000035650
Ganab
glucosidase II alpha subunit
chr11_-_64752544 6.70 ENSRNOT00000048738
Tmem39a
transmembrane protein 39a
chr16_-_71125316 6.68 ENSRNOT00000020900
Plpp5
phospholipid phosphatase 5
chr10_+_65448950 6.64 ENSRNOT00000082348
ENSRNOT00000037016
Rab34
RAB34, member RAS oncogene family
chr10_-_105149971 6.56 ENSRNOT00000012436
Srp68
signal recognition particle 68
chr11_+_64601029 6.40 ENSRNOT00000004138
Arhgap31
Rho GTPase activating protein 31
chr17_-_1830001 6.31 ENSRNOT00000066230
Aaed1
AhpC/TSA antioxidant enzyme domain containing 1
chr7_-_2819299 6.11 ENSRNOT00000045547
Slc39a5
solute carrier family 39 member 5
chr8_-_39243882 5.91 ENSRNOT00000082086
Stt3a
STT3A, catalytic subunit of the oligosaccharyltransferase complex
chr11_-_66819079 5.81 ENSRNOT00000003255
Golgb1
golgin B1
chr12_-_37480297 5.77 ENSRNOT00000001397
Tmed2
transmembrane p24 trafficking protein 2
chr11_-_51202703 5.74 ENSRNOT00000002719
ENSRNOT00000077220
Cblb
Cbl proto-oncogene B
chr8_-_39243705 5.71 ENSRNOT00000043518
Stt3a
STT3A, catalytic subunit of the oligosaccharyltransferase complex
chr2_+_9526209 5.62 ENSRNOT00000021818
Lysmd3
LysM domain containing 3
chr10_-_105228547 5.43 ENSRNOT00000028875
Srp68
signal recognition particle 68
chr19_-_38120578 5.36 ENSRNOT00000026873
Esrp2
epithelial splicing regulatory protein 2
chr17_+_82065937 5.01 ENSRNOT00000051349
Arl5b
ADP-ribosylation factor like GTPase 5B
chr19_-_37938857 4.96 ENSRNOT00000026730
Slc12a4
solute carrier family 12 member 4
chr6_+_91476698 4.88 ENSRNOT00000005608
Mgat2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr1_+_164425475 4.86 ENSRNOT00000023386
Klhl35
kelch-like family member 35
chr4_-_29092753 4.72 ENSRNOT00000014810
Bet1
Bet1 golgi vesicular membrane trafficking protein
chr16_-_20873344 4.68 ENSRNOT00000027381
Cope
coatomer protein complex, subunit epsilon
chr1_+_221644867 4.61 ENSRNOT00000054830
Ehd1
EH-domain containing 1
chr16_+_19501193 4.54 ENSRNOT00000085328
Cyp4f18
cytochrome P450, family 4, subfamily f, polypeptide 18
chr20_+_22728208 4.43 ENSRNOT00000000794
LOC100363472
nuclear receptor-binding factor 2-like
chr2_+_85377318 4.29 ENSRNOT00000016506
ENSRNOT00000085094
Sema5a
semaphorin 5A
chr20_+_31298269 4.28 ENSRNOT00000000673
Ppa1
pyrophosphatase (inorganic) 1
chr7_-_97759852 4.24 ENSRNOT00000007484
Derl1
derlin 1
chr2_+_198823366 4.23 ENSRNOT00000083769
ENSRNOT00000028814
Pias3
protein inhibitor of activated STAT, 3
chr14_-_17436897 4.21 ENSRNOT00000003277
Uso1
USO1 vesicle transport factor
chr5_-_24631679 4.11 ENSRNOT00000010846
ENSRNOT00000067129
Esrp1
epithelial splicing regulatory protein 1
chrX_-_34162827 3.95 ENSRNOT00000046759
RGD1560203
similar to ferritin heavy polypeptide-like 17
chr8_-_49075892 3.82 ENSRNOT00000082687
Arcn1
archain 1
chr4_+_113948514 3.79 ENSRNOT00000011521
LOC103692171
mannosyl-oligosaccharide glucosidase
chr4_-_145699577 3.73 ENSRNOT00000014377
Sec13
SEC13 homolog, nuclear pore and COPII coat complex component
chr15_-_34322115 3.71 ENSRNOT00000026734
Tm9sf1
transmembrane 9 superfamily member 1
chr13_+_89253617 3.61 ENSRNOT00000044575
LOC100362384
ferritin light chain 1-like
chr19_+_39357791 3.35 ENSRNOT00000086435
ENSRNOT00000015006
Cyb5b
cytochrome b5 type B
chr8_+_79606789 3.35 ENSRNOT00000087114
Pygo1
pygopus family PHD finger 1
chr17_+_82066152 3.06 ENSRNOT00000083034
Arl5b
ADP-ribosylation factor like GTPase 5B
chr1_-_190965115 2.99 ENSRNOT00000023483
AC103221.1

chr15_-_45927804 2.98 ENSRNOT00000086271
Ints6
integrator complex subunit 6
chr5_+_59063531 2.96 ENSRNOT00000085311
ENSRNOT00000065909
Creb3
cAMP responsive element binding protein 3
chr7_+_29282305 2.93 ENSRNOT00000007623
Arl1
ADP-ribosylation factor like GTPase 1
chr1_-_260517323 2.80 ENSRNOT00000018043
Tm9sf3
transmembrane 9 superfamily member 3
chr12_+_47218969 2.80 ENSRNOT00000081343
ENSRNOT00000038395
Unc119b
unc-119 lipid binding chaperone B
chr2_-_183582553 2.72 ENSRNOT00000014236
Arfip1
ADP-ribosylation factor interacting protein 1
chr3_+_56966654 2.71 ENSRNOT00000088097
Gorasp2
golgi reassembly stacking protein 2
chr4_+_118852062 2.70 ENSRNOT00000090827
ENSRNOT00000025070
Gfpt1
glutamine fructose-6-phosphate transaminase 1
chr7_-_124198200 2.66 ENSRNOT00000078947
Arfgap3
ADP-ribosylation factor GTPase activating protein 3
chr8_+_62341613 2.65 ENSRNOT00000066923
Scamp2
secretory carrier membrane protein 2
chr5_-_117612123 2.53 ENSRNOT00000065112
Dock7
dedicator of cytokinesis 7
chr3_-_95418679 2.51 ENSRNOT00000018074
Rcn1
reticulocalbin 1
chrX_+_73390903 2.44 ENSRNOT00000077002
Zfp449
zinc finger protein 449
chr9_+_100080144 2.38 ENSRNOT00000071411
Rnpepl1
arginyl aminopeptidase like 1
chr1_+_266530477 2.36 ENSRNOT00000054699
Cnnm2
cyclin and CBS domain divalent metal cation transport mediator 2
chr9_-_82673898 2.34 ENSRNOT00000027165
Chpf
chondroitin polymerizing factor
chr5_-_152920343 2.31 ENSRNOT00000022956
Man1c1
mannosidase, alpha, class 1C, member 1
chr1_-_6970040 2.24 ENSRNOT00000016273
Utrn
utrophin
chr18_+_1504178 2.11 ENSRNOT00000048198
Rpl36al
ribosomal protein L36a-like
chr13_-_90467235 2.09 ENSRNOT00000081534
ENSRNOT00000008150
Ncstn
nicastrin
chr7_-_31784192 2.01 ENSRNOT00000010869
Apaf1
apoptotic peptidase activating factor 1
chr12_-_12407561 1.98 ENSRNOT00000037251
Bhlha15
basic helix-loop-helix family, member a15
chr7_-_24668250 1.94 ENSRNOT00000083806
Tmem263
transmembrane protein 263
chrX_+_9815652 1.93 ENSRNOT00000091382
LOC100910506
peripheral plasma membrane protein CASK-like
chr15_-_57805184 1.92 ENSRNOT00000000168
Cog3
component of oligomeric golgi complex 3
chr1_-_141188031 1.83 ENSRNOT00000044567
Polg
DNA polymerase gamma, catalytic subunit
chr19_-_37210412 1.72 ENSRNOT00000083097
B3gnt9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr9_-_61810417 1.66 ENSRNOT00000020910
Rftn2
raftlin family member 2
chr2_-_2891253 1.64 ENSRNOT00000029250
Arsk
arylsulfatase family, member K
chr16_-_49484985 1.55 ENSRNOT00000016723
Ufsp2
UFM1-specific peptidase 2
chr3_+_11317183 1.51 ENSRNOT00000091171
ENSRNOT00000016341
Golga2
golgin A2
chr7_-_11406771 1.50 ENSRNOT00000047450
Eef2
eukaryotic translation elongation factor 2
chr3_-_10269693 1.50 ENSRNOT00000021871
Fubp3
far upstream element binding protein 3
chr15_-_4057104 1.49 ENSRNOT00000084350
ENSRNOT00000012270
Sec24c
SEC24 homolog C, COPII coat complex component
chr10_-_84789832 1.47 ENSRNOT00000071719
Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr5_-_39650894 1.47 ENSRNOT00000010421
ENSRNOT00000089522
Ufl1
Ufm1-specific ligase 1
chr7_+_66717267 1.39 ENSRNOT00000005654
Mon2
MON2 homolog, regulator of endosome-to-Golgi trafficking
chr1_-_220067123 1.21 ENSRNOT00000071020
ENSRNOT00000072373
Rbm14
RNA binding motif protein 14
chr6_+_21051327 1.21 ENSRNOT00000052131
Fam98a
family with sequence similarity 98, member A
chr16_+_20873642 1.12 ENSRNOT00000004891
Ddx49
DEAD-box helicase 49
chr1_-_87174530 1.10 ENSRNOT00000089578
Kcnk6
potassium two pore domain channel subfamily K member 6
chr3_+_14889510 0.98 ENSRNOT00000080760
Dab2ip
DAB2 interacting protein
chr6_+_38474804 0.95 ENSRNOT00000009779
Nbas
neuroblastoma amplified sequence
chr4_+_342302 0.92 ENSRNOT00000009233
Insig1
insulin induced gene 1
chr2_-_30846149 0.91 ENSRNOT00000025506
Slc30a5
solute carrier family 30 member 5
chr7_-_11444786 0.82 ENSRNOT00000027323
Zbtb7a
zinc finger and BTB domain containing 7a
chr17_-_85141210 0.79 ENSRNOT00000000162
Dnajc1
DnaJ heat shock protein family (Hsp40) member C1
chr2_-_211352540 0.77 ENSRNOT00000023728
LOC108349010
protein kish-B
chr14_+_38192870 0.73 ENSRNOT00000077080
Nfxl1
nuclear transcription factor, X-box binding-like 1
chrX_+_45637415 0.72 ENSRNOT00000050544
RGD1563378
similar to ferritin heavy polypeptide-like 17
chr9_+_61810859 0.66 ENSRNOT00000079058
AABR07067763.1

chr5_-_152227677 0.65 ENSRNOT00000020051
Dhdds
dehydrodolichyl diphosphate synthase subunit
chr3_+_160945359 0.64 ENSRNOT00000019761
Pigt
phosphatidylinositol glycan anchor biosynthesis, class T
chr13_+_90467265 0.45 ENSRNOT00000008518
Copa
coatomer protein complex subunit alpha
chr7_+_117951154 0.34 ENSRNOT00000060181
Znf7
zinc finger protein 7
chr12_-_52558606 0.28 ENSRNOT00000056656
Golga3
golgin A3
chr10_-_16689321 0.21 ENSRNOT00000028173
Bnip1
BCL2/adenovirus E1B interacting protein 1
chr8_+_5790034 0.20 ENSRNOT00000061887
Mmp27
matrix metallopeptidase 27
chr10_-_56558487 0.20 ENSRNOT00000023256
Slc2a4
solute carrier family 2 member 4
chr11_-_16889201 0.16 ENSRNOT00000002121
Btg3
BTG anti-proliferation factor 3
chr10_-_59360661 0.14 ENSRNOT00000036942
Cyb5d2
cytochrome b5 domain containing 2
chr1_+_241501679 0.08 ENSRNOT00000054775
Ptar1
protein prenyltransferase alpha subunit repeat containing 1
chr5_+_62109328 0.04 ENSRNOT00000012260
Nans
N-acetylneuraminate synthase

Network of associatons between targets according to the STRING database.

First level regulatory network of Xbp1_Creb3l1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 22.8 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
7.0 48.9 GO:0006621 protein retention in ER lumen(GO:0006621)
5.9 17.8 GO:0002353 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) activation of plasma proteins involved in acute inflammatory response(GO:0002541)
4.7 14.0 GO:0035359 negative regulation of histone phosphorylation(GO:0033128) negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
3.9 11.6 GO:2000384 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
3.7 11.1 GO:2000845 positive regulation of testosterone secretion(GO:2000845)
3.3 13.4 GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
3.2 9.7 GO:0060764 cell-cell signaling involved in mammary gland development(GO:0060764)
2.8 28.0 GO:0048251 elastic fiber assembly(GO:0048251)
2.8 8.3 GO:2000158 flavin-containing compound metabolic process(GO:0042726) positive regulation of ubiquitin-specific protease activity(GO:2000158)
2.5 7.4 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
2.3 11.4 GO:0039019 pronephric nephron development(GO:0039019)
2.0 6.1 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
1.8 29.5 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
1.8 11.0 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
1.8 12.8 GO:0000103 sulfate assimilation(GO:0000103)
1.8 12.5 GO:0031584 activation of phospholipase D activity(GO:0031584)
1.7 11.6 GO:0043686 co-translational protein modification(GO:0043686)
1.5 4.6 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
1.5 4.5 GO:0036101 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
1.3 3.8 GO:0021699 cerebellar cortex maturation(GO:0021699)
1.1 16.9 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
1.1 12.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
1.0 11.5 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
1.0 3.0 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
1.0 5.7 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.9 9.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.8 85.3 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.7 6.6 GO:0044351 macropinocytosis(GO:0044351) phagosome-lysosome fusion(GO:0090385)
0.7 11.9 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.7 2.7 GO:1901073 glucosamine-containing compound biosynthetic process(GO:1901073)
0.6 5.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.6 37.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.5 4.3 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.5 6.7 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.5 1.5 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.5 14.4 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.4 2.5 GO:0071569 protein ufmylation(GO:0071569)
0.4 5.8 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.4 7.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.4 4.2 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.4 9.3 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.4 2.5 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.4 4.2 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.3 9.5 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.3 1.0 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.3 1.8 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.3 1.7 GO:0033227 dsRNA transport(GO:0033227)
0.3 2.0 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.2 15.4 GO:0043462 regulation of ATPase activity(GO:0043462)
0.2 0.7 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.2 2.4 GO:0015693 magnesium ion transport(GO:0015693)
0.2 2.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.2 2.1 GO:0007220 Notch receptor processing(GO:0007220)
0.2 21.2 GO:0008203 cholesterol metabolic process(GO:0008203)
0.2 10.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 1.2 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.2 2.7 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.2 6.7 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.2 7.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 3.3 GO:0007289 spermatid nucleus differentiation(GO:0007289)
0.2 0.9 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 2.0 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.1 6.1 GO:0009311 oligosaccharide metabolic process(GO:0009311)
0.1 2.2 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 3.0 GO:0016180 snRNA processing(GO:0016180)
0.1 0.6 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 25.8 GO:0001649 osteoblast differentiation(GO:0001649)
0.1 6.3 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.1 0.3 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 2.7 GO:0007030 Golgi organization(GO:0007030)
0.0 1.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 5.0 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 9.0 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 0.8 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 22.0 GO:0006508 proteolysis(GO:0006508)
0.0 0.2 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 29.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
3.9 55.0 GO:0030127 COPII vesicle coat(GO:0030127)
3.2 16.0 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
2.9 11.6 GO:0045298 tubulin complex(GO:0045298)
2.8 8.3 GO:1990730 VCP-NSFL1C complex(GO:1990730)
2.8 11.0 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
2.2 15.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
1.6 27.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
1.5 4.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
1.5 9.2 GO:1990393 3M complex(GO:1990393)
1.5 30.6 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
1.4 13.9 GO:0005797 Golgi medial cisterna(GO:0005797)
0.9 10.1 GO:0048500 signal recognition particle(GO:0048500)
0.8 7.7 GO:0097433 dense body(GO:0097433)
0.7 21.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.7 19.3 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.6 1.8 GO:0005760 gamma DNA polymerase complex(GO:0005760)
0.5 37.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.5 21.1 GO:0005801 cis-Golgi network(GO:0005801)
0.5 0.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.4 2.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.4 2.0 GO:0043293 apoptosome(GO:0043293)
0.4 28.0 GO:0005581 collagen trimer(GO:0005581)
0.3 1.0 GO:1990032 climbing fiber(GO:0044301) parallel fiber(GO:1990032)
0.3 0.9 GO:0070939 Dsl1p complex(GO:0070939)
0.3 0.3 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.3 10.0 GO:0008180 COP9 signalosome(GO:0008180)
0.2 6.6 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.2 148.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.2 3.0 GO:0032039 integrator complex(GO:0032039)
0.2 1.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.2 3.7 GO:0000421 autophagosome membrane(GO:0000421)
0.2 1.5 GO:0042788 polysomal ribosome(GO:0042788)
0.2 6.7 GO:0044432 endoplasmic reticulum part(GO:0044432)
0.1 2.2 GO:0070938 contractile ring(GO:0070938)
0.1 3.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 7.2 GO:0005811 lipid particle(GO:0005811)
0.1 13.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 21.1 GO:0001726 ruffle(GO:0001726)
0.1 7.2 GO:0005795 Golgi stack(GO:0005795)
0.1 12.1 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 15.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 4.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 7.9 GO:0030018 Z disc(GO:0030018)
0.0 6.4 GO:0030027 lamellipodium(GO:0030027)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 8.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 7.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 14.4 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.8 48.9 GO:0046923 ER retention sequence binding(GO:0046923)
5.6 28.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
4.3 12.8 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
4.0 12.1 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
3.0 12.0 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
3.0 11.9 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768)
2.8 8.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
2.8 11.0 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
2.1 8.5 GO:0048408 epidermal growth factor binding(GO:0048408)
2.0 27.4 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
1.9 38.9 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
1.5 4.5 GO:0050051 leukotriene-B4 20-monooxygenase activity(GO:0050051) tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871)
1.4 11.5 GO:0030274 LIM domain binding(GO:0030274)
1.2 19.8 GO:0035497 cAMP response element binding(GO:0035497)
1.1 4.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.9 2.7 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.9 4.3 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.8 7.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.7 9.2 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.6 8.2 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.5 15.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 5.0 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.4 15.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.4 14.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.4 6.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.4 6.6 GO:0017160 Ral GTPase binding(GO:0017160)
0.3 6.7 GO:0008199 ferric iron binding(GO:0008199)
0.3 1.5 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.3 4.2 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.3 9.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.3 11.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 1.0 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 29.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 3.8 GO:0015926 glucosidase activity(GO:0015926)
0.2 22.9 GO:0008565 protein transporter activity(GO:0008565)
0.2 157.6 GO:0005509 calcium ion binding(GO:0005509)
0.2 2.2 GO:0017166 vinculin binding(GO:0017166)
0.2 2.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.2 1.6 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.2 2.0 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 19.8 GO:0017124 SH3 domain binding(GO:0017124)
0.1 2.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 6.7 GO:0043022 ribosome binding(GO:0043022)
0.1 0.6 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 2.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 2.3 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 4.9 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 4.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 1.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 6.7 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 6.3 GO:0016209 antioxidant activity(GO:0016209)
0.1 4.7 GO:0019905 syntaxin binding(GO:0019905)
0.1 1.7 GO:0008378 galactosyltransferase activity(GO:0008378)
0.1 1.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 2.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 11.2 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.1 3.4 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.7 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 9.5 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 9.0 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 1.5 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 33.6 GO:0008270 zinc ion binding(GO:0008270)
0.0 9.2 GO:0005525 GTP binding(GO:0005525)
0.0 0.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 2.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 14.9 GO:0042802 identical protein binding(GO:0042802)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 13.9 PID ARF 3PATHWAY Arf1 pathway
0.4 4.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.4 11.5 PID NECTIN PATHWAY Nectin adhesion pathway
0.3 14.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 57.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 13.1 PID PLK1 PATHWAY PLK1 signaling events
0.2 3.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.2 2.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 5.7 PID CD40 PATHWAY CD40/CD40L signaling
0.1 2.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 2.5 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 2.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 4.5 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 3.8 PID CMYB PATHWAY C-MYB transcription factor network
0.0 3.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.0 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 4.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 51.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.5 70.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
1.2 11.9 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
1.1 6.7 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
1.0 24.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
1.0 8.9 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
1.0 12.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.8 17.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.8 16.0 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.8 1.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.5 59.5 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.4 15.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.3 7.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.3 5.8 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.3 18.8 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.2 4.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 2.1 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.2 16.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 5.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 1.6 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 4.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.0 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 5.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 6.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 4.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters