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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zbtb16

Z-value: 1.10

Motif logo

Transcription factors associated with Zbtb16

Gene Symbol Gene ID Gene Info
ENSRNOG00000029980 zinc finger and BTB domain containing 16

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zbtb16rn6_v1_chr8_-_53146953_53146953-0.312.1e-08Click!

Activity profile of Zbtb16 motif

Sorted Z-values of Zbtb16 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_163762434 56.70 ENSRNOT00000081854
immunoreceptor Ly49si1
chr4_-_164051812 56.01 ENSRNOT00000085719

chr10_-_85947938 35.57 ENSRNOT00000037318
ENSRNOT00000082427
ADP-ribosylation factor like GTPase 5C
chr4_-_163954817 35.41 ENSRNOT00000079951
immunoreceptor Ly49si3
chr4_-_164015365 33.84 ENSRNOT00000078121
immunoreceptor Ly49si2
chr20_+_3875706 33.81 ENSRNOT00000036900
RT1 class II, locus Ha
chr4_-_163849618 33.38 ENSRNOT00000086363
ENSRNOT00000077637
immunoreceptor Ly49si1
chr17_+_43633675 32.11 ENSRNOT00000072119
histone H3.2-like
chr4_-_163810403 31.84 ENSRNOT00000079704

chr20_-_1878126 31.83 ENSRNOT00000000995
ubiquitin D
chr6_+_122254841 29.36 ENSRNOT00000005055
G-protein coupled receptor 65
chr4_-_164123974 26.50 ENSRNOT00000082447
similar to immunoreceptor Ly49si1
chr11_-_60547201 22.26 ENSRNOT00000093151
B and T lymphocyte associated
chr16_-_75481115 22.21 ENSRNOT00000035128
defensin alpha 7
chr7_-_118792625 21.97 ENSRNOT00000007398
myosin, heavy chain 9
chr4_-_164174725 20.94 ENSRNOT00000080754

chr4_+_14109864 20.94 ENSRNOT00000076349
similar to fatty acid translocase/CD36
chr13_-_100450209 20.65 ENSRNOT00000090712
lamin B receptor
chr10_+_30038709 20.51 ENSRNOT00000005898
interleukin 12B
chr13_-_61591139 19.92 ENSRNOT00000005324
regulator of G-protein signaling 18
chr1_+_81763614 18.87 ENSRNOT00000027254
CD79a molecule
chrX_+_28486869 18.82 ENSRNOT00000005620
toll-like receptor 7
chr11_-_60546997 18.82 ENSRNOT00000083124
ENSRNOT00000050092
B and T lymphocyte associated
chr3_-_2853272 18.27 ENSRNOT00000023022
ficolin A
chr9_-_16795887 17.90 ENSRNOT00000071609
Cd79a molecule-like
chr3_+_100373439 17.79 ENSRNOT00000085176
kinesin family member 18A
chr1_+_223214132 17.55 ENSRNOT00000066559

chr6_-_140572023 17.37 ENSRNOT00000072338

chr9_+_92681078 16.65 ENSRNOT00000034152
SP100 nuclear antigen
chr6_-_140407307 16.64 ENSRNOT00000079087

chr14_-_82347679 16.39 ENSRNOT00000032972
transforming, acidic coiled-coil containing protein 3
chr4_-_163463718 15.63 ENSRNOT00000085671
killer cell lectin like receptor C1
chr20_-_14025067 15.62 ENSRNOT00000093430
ENSRNOT00000074533
gamma-glutamyltransferase 1
chr19_+_26016382 15.60 ENSRNOT00000004601
Kruppel like factor 1
chr3_+_20375699 15.43 ENSRNOT00000088492

chr9_+_91001828 15.08 ENSRNOT00000080956

chr7_-_2961873 14.53 ENSRNOT00000067441
ribosomal protein S15, pseudogene 2
chr15_+_31642169 14.43 ENSRNOT00000072362

chr18_-_411849 14.38 ENSRNOT00000033663
mature T-cell proliferation 1
chr2_-_54777729 14.16 ENSRNOT00000082548
complement C7
chr2_-_202350929 14.03 ENSRNOT00000026306
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
chr5_+_154260062 13.98 ENSRNOT00000074998
cannabinoid receptor 2
chr12_-_2438817 13.89 ENSRNOT00000037059
C-C motif chemokine ligand 25
chr4_-_165118062 13.69 ENSRNOT00000087219
Ly49s8
chr13_+_53351717 12.83 ENSRNOT00000012038
kinesin family member 14
chr7_+_71065197 12.66 ENSRNOT00000051075
retinol dehydrogenase 16 (all-trans)
chr3_-_10153554 12.53 ENSRNOT00000093246
exosome component 2
chr14_-_86078954 12.47 ENSRNOT00000018319
DNA polymerase mu
chr13_-_92210052 12.45 ENSRNOT00000004670
olfactory receptor 1592
chr2_-_31753528 11.79 ENSRNOT00000075057
phosphoinositide-3-kinase regulatory subunit 1
chr18_+_44716226 11.71 ENSRNOT00000086431
TNF alpha induced protein 8
chr8_-_84320714 11.63 ENSRNOT00000079356
ENSRNOT00000088487
tubulointerstitial nephritis antigen
chr1_+_227640680 11.38 ENSRNOT00000033613
membrane-spanning 4-domains, subfamily A, member 4C
chr18_+_56414488 11.36 ENSRNOT00000088988
colony stimulating factor 1 receptor
chr2_-_56151531 11.24 ENSRNOT00000040847
ENSRNOT00000080677
oncostatin M receptor
chr11_+_64472072 11.17 ENSRNOT00000042756
similar to ribosomal protein L27
chr3_-_118635268 10.99 ENSRNOT00000086357
ATPase phospholipid transporting 8B4 (putative)
chr14_-_88886198 10.94 ENSRNOT00000012661
tensin 3
chr4_+_171748273 10.93 ENSRNOT00000009998
deoxyribose-phosphate aldolase
chr2_+_153830586 10.91 ENSRNOT00000042576
membrane metallo-endopeptidase
chr4_+_162937774 10.81 ENSRNOT00000083188
C-type lectin domain family 2, member G
chr4_-_162680757 10.79 ENSRNOT00000085918
killer cell lectin-like receptor, subfamily A, member 5
chr1_+_229416489 10.73 ENSRNOT00000028617
olfactory receptor 336
chr13_-_99531959 10.67 ENSRNOT00000005059
WD repeat domain 26
chr7_-_60860990 10.59 ENSRNOT00000009511
RAP1B, member of RAS oncogene family
chr10_-_103590607 10.51 ENSRNOT00000034741
Cd300 molecule-like family member E
chr6_-_99576196 10.20 ENSRNOT00000040565
similar to ribosomal protein S17
chr14_+_46001849 10.05 ENSRNOT00000076611
RELT-like 1
chr10_+_89484468 9.98 ENSRNOT00000035523
transmembrane protein 106A
chr4_-_164304532 9.91 ENSRNOT00000089484
Ly49 inhibitory receptor 5
chr2_+_240396152 9.76 ENSRNOT00000034565
centromere protein E
chr9_+_65620658 9.74 ENSRNOT00000084498
caspase 8
chr1_-_22269831 9.65 ENSRNOT00000081804
syntaxin 7
chr8_-_119326938 9.64 ENSRNOT00000044467
C-C motif chemokine receptor like 2
chr19_-_55389256 9.63 ENSRNOT00000064180
adenine phosphoribosyl transferase
chr2_+_178679395 9.23 ENSRNOT00000088686
family with sequence similarity 198, member B
chr9_-_20621051 9.04 ENSRNOT00000015918
TNF receptor superfamily member 21
chr7_+_12535527 9.01 ENSRNOT00000093135
RNA polymerase II subunit E
chr10_+_15484795 9.00 ENSRNOT00000079826
transmembrane protein 8A
chr6_-_146195819 8.97 ENSRNOT00000007625
Sp4 transcription factor
chr1_+_68436917 8.73 ENSRNOT00000088586
leucyl-cystinyl aminopeptidase
chr6_-_145777767 8.52 ENSRNOT00000046799
ribosomal protein L32
chr9_-_17212628 8.48 ENSRNOT00000002656
ENSRNOT00000007876
similar to 40S ribosomal protein S2
chr2_-_33920837 8.44 ENSRNOT00000075196
erbb2 interacting protein
chr4_-_103569159 8.39 ENSRNOT00000084036

chr1_+_247562202 8.34 ENSRNOT00000021614
programmed cell death 1 ligand 2
chr15_-_36798814 8.33 ENSRNOT00000065764
centromere protein J
chr1_-_134870255 8.27 ENSRNOT00000055829
chromodomain helicase DNA binding protein 2
chr1_+_68436593 8.25 ENSRNOT00000080325
leucyl-cystinyl aminopeptidase
chr20_-_5805627 8.17 ENSRNOT00000085996
colipase
chr19_-_38484611 8.16 ENSRNOT00000077960
nuclear factor of activated T-cells 5
chr19_+_24849356 8.14 ENSRNOT00000090312
DExD-box helicase 39A
chr9_+_61738471 8.13 ENSRNOT00000090305

chr4_+_163112301 8.10 ENSRNOT00000087113
C-type lectin domain family 12, member A
chr3_-_72071895 7.84 ENSRNOT00000082857
selenoprotein H
chr9_+_65172194 7.66 ENSRNOT00000040493

chr12_-_40686249 7.56 ENSRNOT00000042264
40S ribosomal protein S20-like
chr6_+_135680615 7.56 ENSRNOT00000077770
Tnf receptor-associated factor 3
chr8_-_21453190 7.52 ENSRNOT00000078192
zinc finger protein 26
chr12_-_46414434 7.49 ENSRNOT00000041281
citron rho-interacting serine/threonine kinase
chr8_+_116754178 7.43 ENSRNOT00000068295
ENSRNOT00000084429
ubiquitin-like modifier activating enzyme 7
chr17_-_89163113 7.39 ENSRNOT00000050445
ribosomal protein S19-like
chr15_-_27726646 7.37 ENSRNOT00000082139
cyclin B1 interacting protein 1
chr14_+_104452917 7.29 ENSRNOT00000050489
similar to 60S ribosomal protein L38
chr4_-_163649637 7.19 ENSRNOT00000080873
similar to killer cell lectin-like receptor, subfamily A, member 17
chr1_+_91716383 7.08 ENSRNOT00000016919
solute carrier family 7 member 9
chr1_-_73732118 6.90 ENSRNOT00000077964
leukocyte receptor cluster member 8
chr6_+_95826546 6.81 ENSRNOT00000043587

chr10_-_76039964 6.77 ENSRNOT00000003164
musashi RNA-binding protein 2
chr4_-_165522418 6.70 ENSRNOT00000064420
mago homolog B, exon junction complex core component
chr1_-_91588609 6.68 ENSRNOT00000050931
small nuclear ribonucleoprotein polypeptide G
chr1_-_89258935 6.66 ENSRNOT00000003180
ribosomal protein L36-like
chr2_+_26240385 6.64 ENSRNOT00000024292
coagulation factor II (thrombin) receptor-like 2
chr8_+_23193181 6.59 ENSRNOT00000071703
zinc finger protein 872
chr19_-_9843673 6.56 ENSRNOT00000015795
GINS complex subunit 3
chr3_+_112346627 6.43 ENSRNOT00000074392
synaptosomal-associated protein 23
chr10_+_104036367 6.40 ENSRNOT00000004843
armadillo repeat containing 7
chrX_-_1076850 6.31 ENSRNOT00000090671
zinc finger protein 81 (HFZ20)-like
chr9_-_88534710 6.31 ENSRNOT00000020880
transmembrane 4 L six family member 20
chr16_-_80850340 6.22 ENSRNOT00000000124
chromosome alignment maintaining phosphoprotein 1
chrX_+_77119911 6.16 ENSRNOT00000080141
ATPase copper transporting alpha
chr1_+_198960542 6.09 ENSRNOT00000072389
Snf2-related CREBBP activator protein
chr4_-_165361623 6.01 ENSRNOT00000088908
immunoreceptor Ly49i7
chr12_-_11808977 5.96 ENSRNOT00000071795

chrX_+_40286592 5.95 ENSRNOT00000087898
membrane-bound transcription factor peptidase, site 2
chr4_+_31704747 5.94 ENSRNOT00000047850

chr15_-_34263224 5.92 ENSRNOT00000026001
ER membrane protein complex subunit 9
chr5_+_57657909 5.88 ENSRNOT00000073017
similar to ribosomal protein S13
chr2_+_251805392 5.88 ENSRNOT00000019911
B-cell CLL/lymphoma 10
chr12_+_11179329 5.87 ENSRNOT00000001302
zinc finger protein 394
chr1_-_72329856 5.87 ENSRNOT00000021391
U2 small nuclear RNA auxiliary factor 2
chr12_-_6879154 5.87 ENSRNOT00000001207
arachidonate 5-lipoxygenase activating protein
chr8_+_82038967 5.83 ENSRNOT00000079535
myosin VA
chr5_-_60871705 5.78 ENSRNOT00000016582
exosome component 3
chr10_-_94652658 5.72 ENSRNOT00000017371
endoplasmic reticulum to nucleus signaling 1
chr1_-_221233905 5.71 ENSRNOT00000092740
ENSRNOT00000028331
FERM domain containing 8
chr2_+_2694480 5.60 ENSRNOT00000083565

chr3_-_4341771 5.55 ENSRNOT00000034694
similar to ribosomal protein S13
chr11_-_72814850 5.55 ENSRNOT00000091575
UBX domain-containing protein 7-like
chr12_-_43576754 5.53 ENSRNOT00000042331
ENSRNOT00000081780
mediator complex subunit 13-like
chr4_-_162726628 5.42 ENSRNOT00000073877
killer cell lectin-like receptor 5-like
chrX_+_119390013 5.40 ENSRNOT00000074269
angiotensin II receptor, type 2
chr12_-_21973474 5.36 ENSRNOT00000071110
similar to Zinc finger, CW type with PWWP domain 1
chr15_+_37171052 5.33 ENSRNOT00000011684
zinc finger MYM-type containing 2
chr16_+_21518873 5.33 ENSRNOT00000015635
zinc finger protein 868
chr3_+_156886454 5.24 ENSRNOT00000022403
lipin 3
chr17_-_90522091 5.21 ENSRNOT00000077767
lysosomal trafficking regulator
chr5_+_135354700 5.20 ENSRNOT00000021850
intracisternal A particle-promoted polypeptide
chr8_+_119214541 5.12 ENSRNOT00000050117
similar to 60S ribosomal protein L29 (P23)
chr12_-_13462038 5.06 ENSRNOT00000043110
ribosomal protein L36-like
chr3_+_80670140 5.06 ENSRNOT00000085614
autophagy and beclin 1 regulator 1
chr10_+_65552897 5.01 ENSRNOT00000056217
sperm associated antigen 5
chr4_-_120408232 5.00 ENSRNOT00000073269
40S ribosomal protein S25-like
chr1_+_11963836 4.93 ENSRNOT00000074325

chr10_-_5344121 4.91 ENSRNOT00000003479
nucleotide binding protein 1
chr8_-_13906355 4.87 ENSRNOT00000029634
centrosomal protein 295
chr14_-_21299068 4.83 ENSRNOT00000065778
amelotin
chr5_-_135994848 4.82 ENSRNOT00000067675
BTB domain containing 19
chr3_+_21983841 4.81 ENSRNOT00000043621
similar to 40S ribosomal protein S16
chr5_-_12199283 4.81 ENSRNOT00000007769
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
chr6_-_91676344 4.80 ENSRNOT00000083872
nuclear export mediator factor
chr7_+_121361415 4.79 ENSRNOT00000067904
TGF-beta activated kinase 1/MAP3K7 binding protein 1
chr20_-_26852199 4.65 ENSRNOT00000078739
sirtuin 1
chr1_-_78110786 4.55 ENSRNOT00000089718
DExH-box helicase 34
chr18_-_72649915 4.52 ENSRNOT00000072205

chr16_+_19767264 4.51 ENSRNOT00000051802
ENSRNOT00000092073
occludin/ELL domain containing 1
chr2_-_235161263 4.51 ENSRNOT00000080235
uncharacterized LOC103691699
chr5_-_50068706 4.51 ENSRNOT00000084643
origin recognition complex, subunit 3
chr2_+_243425007 4.48 ENSRNOT00000082894
tRNA methyltransferase 10A
chr14_+_17195014 4.44 ENSRNOT00000031667
C-X-C motif chemokine ligand 11
chr20_-_3440769 4.44 ENSRNOT00000084981
immediate early response 3
chr17_-_66288202 4.43 ENSRNOT00000083172
5-methyltetrahydrofolate-homocysteine methyltransferase
chr12_+_47590154 4.36 ENSRNOT00000045946
GIT ArfGAP 2
chr2_-_106703401 4.31 ENSRNOT00000043933

chr10_+_66509107 4.28 ENSRNOT00000017230
similar to ubiquitin-like/S30 ribosomal fusion protein
chr17_+_1305016 4.22 ENSRNOT00000025965
ERCC excision repair 6 like 2
chr5_-_138361702 4.20 ENSRNOT00000067943
ENSRNOT00000064712
peptidylprolyl isomerase H
chr13_-_91737053 4.19 ENSRNOT00000083561
Fc fragment of IgE receptor Ia
chr17_-_6892497 4.06 ENSRNOT00000026407
Idnk, gluconokinase
chr1_-_238376841 4.03 ENSRNOT00000076393
transmembrane channel-like 1
chr18_+_76317134 4.01 ENSRNOT00000074465
mitochondrial ribosomal protein S21-like
chr7_-_123476238 4.01 ENSRNOT00000036917
centromere protein M
chr14_-_45376127 3.96 ENSRNOT00000059247

chr10_-_97750679 3.95 ENSRNOT00000078059
solute carrier family 16, member 6
chr2_-_66608324 3.93 ENSRNOT00000077597
ceroid-lipofuscinosis, neuronal 5
chr12_-_40822159 3.89 ENSRNOT00000001826
HECT domain E3 ubiquitin protein ligase 4
chr15_+_49010492 3.89 ENSRNOT00000024527
nuclear GTPase, germinal center associated
chr17_+_53965562 3.86 ENSRNOT00000090387
geranylgeranyl diphosphate synthase 1
chr2_+_236625357 3.85 ENSRNOT00000081248
3'-phosphoadenosine 5'-phosphosulfate synthase 1
chr13_-_81214494 3.79 ENSRNOT00000004950
ENSRNOT00000082385
paired related homeobox 1
chr1_-_84732242 3.76 ENSRNOT00000025586
zinc finger protein 59-like
chr6_+_107001763 3.75 ENSRNOT00000011378
DDB1 and CUL4 associated factor 4
chr16_-_19583386 3.73 ENSRNOT00000090131
zinc finger protein 617
chr3_+_111298713 3.65 ENSRNOT00000043677
developmental pluripotency-associated 3
chr6_+_10642700 3.64 ENSRNOT00000040329
karyopherin alpha 2-like
chr16_+_2278701 3.58 ENSRNOT00000016233
DENN domain containing 6A
chr5_-_141363524 3.56 ENSRNOT00000084109
microtubule-actin crosslinking factor 1
chr17_+_13519130 3.53 ENSRNOT00000076794
semaphorin 4D
chr4_+_155531906 3.51 ENSRNOT00000060937
Nanog homeobox
chr13_-_25652473 3.50 ENSRNOT00000020752
phosphatidylinositol glycan anchor biosynthesis, class N

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb16

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 22.0 GO:1903919 protein processing in phagocytic vesicle(GO:1900756) regulation of actin filament severing(GO:1903918) negative regulation of actin filament severing(GO:1903919) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
6.1 18.3 GO:0071038 nuclear mRNA surveillance of mRNA 3'-end processing(GO:0071031) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
5.5 16.6 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
5.1 20.5 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
4.6 18.3 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
4.3 12.8 GO:0021698 cerebellar cortex structural organization(GO:0021698)
4.0 31.8 GO:0070842 aggresome assembly(GO:0070842)
3.9 15.6 GO:0031179 peptide modification(GO:0031179)
3.8 18.8 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
3.7 41.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
3.2 9.6 GO:0044209 AMP salvage(GO:0044209)
2.9 5.9 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
2.8 8.4 GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433)
2.8 11.2 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
2.8 13.9 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
2.7 10.9 GO:0071492 cellular response to UV-A(GO:0071492)
2.6 5.2 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
2.4 9.7 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
2.4 7.2 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
2.3 11.4 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
2.3 9.0 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
2.2 6.7 GO:1904638 response to resveratrol(GO:1904638)
2.2 10.9 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
2.1 10.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
2.1 8.3 GO:0061511 centriole elongation(GO:0061511)
2.0 5.9 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
2.0 5.9 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
1.9 33.8 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
1.8 5.4 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) regulation of metanephros size(GO:0035566)
1.8 7.1 GO:0015811 L-cystine transport(GO:0015811)
1.6 4.9 GO:0072697 protein localization to cell cortex(GO:0072697)
1.6 9.8 GO:1902101 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
1.6 4.8 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
1.6 12.7 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.6 14.0 GO:0038171 cannabinoid signaling pathway(GO:0038171)
1.5 6.2 GO:1904959 negative regulation of iron ion transmembrane transport(GO:0034760) elastin biosynthetic process(GO:0051542) regulation of cytochrome-c oxidase activity(GO:1904959)
1.5 4.5 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.5 7.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.5 5.8 GO:0051643 endoplasmic reticulum localization(GO:0051643)
1.4 4.2 GO:0045401 positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
1.3 15.6 GO:0043249 erythrocyte maturation(GO:0043249)
1.3 16.4 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
1.2 3.7 GO:0044726 protection of DNA demethylation of female pronucleus(GO:0044726)
1.2 11.8 GO:0010459 negative regulation of heart rate(GO:0010459)
1.2 3.5 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
1.1 5.7 GO:1903061 positive regulation of protein lipidation(GO:1903061)
1.1 36.0 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
1.1 4.4 GO:1904640 response to methionine(GO:1904640)
1.1 16.4 GO:0030953 astral microtubule organization(GO:0030953)
1.1 3.2 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
1.1 17.0 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
1.0 3.0 GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
1.0 5.7 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.9 12.1 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.9 8.3 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.9 6.4 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.9 3.6 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.9 2.6 GO:0006649 phospholipid transfer to membrane(GO:0006649)
0.8 7.6 GO:0008063 Toll signaling pathway(GO:0008063)
0.8 4.1 GO:0019520 aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.8 4.0 GO:0060005 vestibular reflex(GO:0060005)
0.8 14.2 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.8 6.2 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.8 17.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.8 4.6 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.7 1.5 GO:0003275 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.7 3.9 GO:1904426 positive regulation of GTP binding(GO:1904426)
0.7 2.6 GO:0019042 viral latency(GO:0019042) release from viral latency(GO:0019046)
0.6 2.5 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.6 2.5 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.6 1.7 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.6 1.7 GO:0014908 myotube differentiation involved in skeletal muscle regeneration(GO:0014908)
0.6 2.2 GO:1900170 glucocorticoid mediated signaling pathway(GO:0043402) regulation of glucocorticoid mediated signaling pathway(GO:1900169) negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.5 3.8 GO:0000103 sulfate assimilation(GO:0000103)
0.5 3.2 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.5 5.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.5 8.3 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.5 1.9 GO:2000851 negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322) positive regulation of cortisol secretion(GO:0051464) positive regulation of glucocorticoid secretion(GO:2000851)
0.5 3.2 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.4 3.6 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.4 1.8 GO:0010157 response to chlorate(GO:0010157)
0.4 3.1 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.4 13.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 1.3 GO:0007468 regulation of rhodopsin gene expression(GO:0007468)
0.4 2.0 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.4 8.2 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.4 3.8 GO:0048664 neuron fate determination(GO:0048664)
0.4 12.1 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.4 4.4 GO:0045820 negative regulation of glycolytic process(GO:0045820)
0.4 18.9 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.3 2.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.3 11.4 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.3 32.1 GO:0006334 nucleosome assembly(GO:0006334)
0.3 3.3 GO:0006068 ethanol catabolic process(GO:0006068)
0.3 2.3 GO:0010764 negative regulation of fibroblast migration(GO:0010764) regulation of hepatic stellate cell activation(GO:2000489)
0.3 0.9 GO:1901090 regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094)
0.3 7.5 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.3 4.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.3 4.4 GO:0010818 T cell chemotaxis(GO:0010818) positive regulation of cAMP-mediated signaling(GO:0043950)
0.2 2.7 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.2 1.2 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.2 1.0 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.2 1.7 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 1.4 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.2 4.5 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 0.6 GO:0030327 prenylated protein catabolic process(GO:0030327) CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.2 5.1 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.2 0.4 GO:0045590 positive regulation of memory T cell differentiation(GO:0043382) negative regulation of regulatory T cell differentiation(GO:0045590)
0.2 3.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 2.6 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.2 1.8 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.2 6.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 1.9 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 20.9 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.2 10.5 GO:0016126 sterol biosynthetic process(GO:0016126)
0.2 2.1 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.2 9.0 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.2 8.5 GO:0097421 liver regeneration(GO:0097421)
0.2 0.5 GO:0098939 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.2 3.4 GO:0006450 regulation of translational fidelity(GO:0006450)
0.2 4.4 GO:0048266 behavioral response to pain(GO:0048266)
0.1 10.9 GO:0048286 lung alveolus development(GO:0048286)
0.1 11.7 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 3.3 GO:0010107 potassium ion import(GO:0010107)
0.1 1.5 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.1 2.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 0.4 GO:0006567 threonine catabolic process(GO:0006567)
0.1 1.6 GO:0006517 protein deglycosylation(GO:0006517)
0.1 0.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 2.1 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1 6.6 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 3.1 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.1 0.8 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 0.6 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.1 4.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 3.2 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 3.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 1.7 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.1 1.7 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)
0.1 1.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 1.3 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 2.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 2.9 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.1 4.0 GO:0032094 response to food(GO:0032094)
0.1 0.5 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 3.4 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.1 27.5 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.1 4.6 GO:0051168 nuclear export(GO:0051168)
0.1 5.2 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.3 GO:0001842 neural fold formation(GO:0001842)
0.1 1.1 GO:0070266 necroptotic process(GO:0070266)
0.1 1.9 GO:0000266 mitochondrial fission(GO:0000266)
0.1 3.0 GO:0006664 glycolipid metabolic process(GO:0006664)
0.1 2.0 GO:0001825 blastocyst formation(GO:0001825)
0.1 3.0 GO:1902117 positive regulation of organelle assembly(GO:1902117)
0.0 1.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 4.8 GO:0008213 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0 6.8 GO:0048864 stem cell development(GO:0048864)
0.0 8.0 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.4 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 3.4 GO:0006401 RNA catabolic process(GO:0006401)
0.0 1.2 GO:0006817 phosphate ion transport(GO:0006817)
0.0 8.9 GO:0006260 DNA replication(GO:0006260)
0.0 7.3 GO:0008380 RNA splicing(GO:0008380)
0.0 2.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.6 GO:0001702 gastrulation with mouth forming second(GO:0001702)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 22.0 GO:0097513 myosin II filament(GO:0097513)
4.7 18.9 GO:0019815 B cell receptor complex(GO:0019815)
3.9 11.8 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
3.8 11.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
3.2 9.7 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
2.4 16.6 GO:0030870 Mre11 complex(GO:0030870)
2.1 33.8 GO:0042613 MHC class II protein complex(GO:0042613)
2.0 14.2 GO:0005579 membrane attack complex(GO:0005579)
2.0 17.8 GO:0005828 kinetochore microtubule(GO:0005828)
1.9 5.8 GO:0042642 actomyosin, myosin complex part(GO:0042642)
1.9 18.8 GO:0032009 early phagosome(GO:0032009)
1.7 18.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
1.5 18.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
1.5 4.5 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.4 5.7 GO:1990630 IRE1-RACK1-PP2A complex(GO:1990630)
1.4 4.2 GO:0071001 U4/U6 snRNP(GO:0071001)
1.2 9.7 GO:0070820 tertiary granule(GO:0070820)
1.2 5.9 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
1.1 20.7 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
1.1 3.3 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
1.0 5.9 GO:0089701 U2AF(GO:0089701)
1.0 6.7 GO:0005683 U7 snRNP(GO:0005683)
0.9 4.7 GO:0033553 rDNA heterochromatin(GO:0033553)
0.8 2.3 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.8 9.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.8 9.8 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778) mitotic spindle midzone(GO:1990023)
0.7 12.8 GO:0051233 spindle midzone(GO:0051233)
0.6 31.8 GO:0016235 aggresome(GO:0016235)
0.6 7.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.5 5.9 GO:0072546 ER membrane protein complex(GO:0072546)
0.5 3.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.5 6.4 GO:0042581 specific granule(GO:0042581)
0.5 6.4 GO:0016342 catenin complex(GO:0016342)
0.5 3.7 GO:0001940 male pronucleus(GO:0001940)
0.4 8.4 GO:0030056 hemidesmosome(GO:0030056)
0.4 2.8 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.4 9.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.3 32.1 GO:0000786 nucleosome(GO:0000786)
0.3 7.1 GO:0005775 vacuolar lumen(GO:0005775)
0.3 2.6 GO:0000813 ESCRT I complex(GO:0000813)
0.3 4.0 GO:0032426 stereocilium tip(GO:0032426)
0.3 1.4 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.3 2.0 GO:0042583 chromaffin granule(GO:0042583)
0.2 0.7 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.2 3.4 GO:0000178 exosome (RNase complex)(GO:0000178)
0.2 3.8 GO:0005682 U5 snRNP(GO:0005682)
0.2 15.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 6.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 1.7 GO:0031209 SCAR complex(GO:0031209)
0.2 4.8 GO:0005605 basal lamina(GO:0005605)
0.2 5.0 GO:0035371 microtubule plus-end(GO:0035371)
0.2 19.0 GO:0005814 centriole(GO:0005814)
0.2 0.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 0.8 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 10.6 GO:0005811 lipid particle(GO:0005811)
0.1 20.5 GO:0005903 brush border(GO:0005903)
0.1 1.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 6.8 GO:0005844 polysome(GO:0005844)
0.1 44.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 10.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 11.0 GO:0005604 basement membrane(GO:0005604)
0.1 0.4 GO:0044194 cytolytic granule(GO:0044194)
0.1 2.2 GO:0019013 viral nucleocapsid(GO:0019013)
0.1 1.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 5.5 GO:0016592 mediator complex(GO:0016592)
0.1 2.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 5.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 9.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.7 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 7.5 GO:0031985 Golgi cisterna(GO:0031985)
0.1 3.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.7 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 6.1 GO:0032587 ruffle membrane(GO:0032587)
0.1 5.3 GO:0016605 PML body(GO:0016605)
0.1 0.8 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 8.8 GO:0005681 spliceosomal complex(GO:0005681)
0.1 5.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 3.6 GO:0005643 nuclear pore(GO:0005643)
0.1 17.7 GO:0005925 focal adhesion(GO:0005925)
0.1 2.1 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 1.0 GO:0044439 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 1.9 GO:0031201 SNARE complex(GO:0031201)
0.0 1.9 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.9 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 3.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.0 GO:0044295 axonal growth cone(GO:0044295)
0.0 2.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.6 GO:0055037 recycling endosome(GO:0055037)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.0 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 8.5 GO:0000790 nuclear chromatin(GO:0000790)
0.0 2.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 4.1 GO:0016604 nuclear body(GO:0016604)
0.0 0.1 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 4.3 GO:0016607 nuclear speck(GO:0016607)
0.0 1.9 GO:0098794 postsynapse(GO:0098794)
0.0 4.5 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 1.6 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 1.6 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 18.4 GO:0005654 nucleoplasm(GO:0005654)
0.0 70.9 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 22.0 GO:0031762 follicle-stimulating hormone receptor binding(GO:0031762)
4.7 37.3 GO:0070087 chromo shadow domain binding(GO:0070087)
4.6 13.9 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
3.7 11.2 GO:0004924 oncostatin-M receptor activity(GO:0004924)
3.5 14.0 GO:0004949 cannabinoid receptor activity(GO:0004949)
3.2 9.6 GO:0002060 purine nucleobase binding(GO:0002060)
2.6 15.6 GO:0036374 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
2.4 9.7 GO:0035877 death effector domain binding(GO:0035877)
2.4 18.8 GO:0035197 siRNA binding(GO:0035197)
2.0 11.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
2.0 5.9 GO:0004464 arachidonate 5-lipoxygenase activity(GO:0004051) leukotriene-C4 synthase activity(GO:0004464)
1.9 30.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.8 7.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
1.7 8.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
1.7 31.8 GO:0070628 proteasome binding(GO:0070628)
1.7 6.6 GO:0015057 thrombin receptor activity(GO:0015057)
1.6 4.7 GO:0043398 HLH domain binding(GO:0043398)
1.5 3.1 GO:0016936 galactoside binding(GO:0016936)
1.4 7.2 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
1.3 3.8 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
1.2 6.2 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-dependent protein binding(GO:0032767) copper-transporting ATPase activity(GO:0043682)
1.2 15.6 GO:1990405 protein antigen binding(GO:1990405)
1.2 4.8 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
1.1 9.0 GO:0001055 RNA polymerase II activity(GO:0001055)
1.1 4.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.1 9.8 GO:0043515 kinetochore binding(GO:0043515)
1.1 5.4 GO:0004945 angiotensin type II receptor activity(GO:0004945)
1.1 3.2 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
1.0 18.3 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.9 4.5 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.9 3.5 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.9 33.8 GO:0042605 peptide antigen binding(GO:0042605)
0.8 9.7 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.8 5.6 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.8 2.3 GO:0004096 catalase activity(GO:0004096)
0.7 6.7 GO:1990446 U1 snRNP binding(GO:1990446)
0.7 17.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.7 10.9 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.7 4.2 GO:0019767 IgE receptor activity(GO:0019767)
0.7 7.4 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.6 3.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.6 4.8 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.6 14.4 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.6 22.2 GO:0004532 exoribonuclease activity(GO:0004532)
0.6 13.8 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.6 4.4 GO:0031419 cobalamin binding(GO:0031419)
0.5 3.2 GO:0033142 progesterone receptor binding(GO:0033142)
0.5 7.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 2.6 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.5 6.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.5 3.4 GO:0008422 beta-glucosidase activity(GO:0008422)
0.5 136.3 GO:0030246 carbohydrate binding(GO:0030246)
0.4 3.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.4 4.0 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.4 9.0 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.4 2.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.4 11.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 12.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 1.2 GO:0052724 inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.4 3.0 GO:0046527 glucosyltransferase activity(GO:0046527)
0.4 1.8 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.4 5.8 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.4 9.6 GO:0004950 chemokine receptor activity(GO:0004950)
0.3 3.3 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 5.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.3 2.8 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.3 5.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.3 20.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.3 1.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.3 2.7 GO:1990239 steroid hormone binding(GO:1990239)
0.3 3.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 4.0 GO:0043422 protein kinase B binding(GO:0043422)
0.3 1.1 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.3 5.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.3 1.8 GO:0043559 insulin binding(GO:0043559)
0.2 1.2 GO:0004568 chitinase activity(GO:0004568)
0.2 2.9 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.2 1.4 GO:0000150 recombinase activity(GO:0000150)
0.2 3.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.2 8.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 8.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 2.1 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 40.8 GO:0042393 histone binding(GO:0042393)
0.2 1.2 GO:0005047 signal recognition particle binding(GO:0005047)
0.2 15.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 1.3 GO:1901612 cardiolipin binding(GO:1901612)
0.2 1.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 2.2 GO:0016805 dipeptidase activity(GO:0016805)
0.2 11.4 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.2 2.7 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 10.6 GO:0019003 GDP binding(GO:0019003)
0.2 4.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 1.0 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 3.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 6.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.4 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.1 2.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 3.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 1.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 27.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 4.5 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 7.5 GO:0097110 scaffold protein binding(GO:0097110)
0.1 2.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.5 GO:0008301 DNA binding, bending(GO:0008301)
0.1 28.6 GO:0005525 GTP binding(GO:0005525)
0.1 2.1 GO:0070412 R-SMAD binding(GO:0070412)
0.1 2.7 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 20.5 GO:0005096 GTPase activator activity(GO:0005096)
0.1 1.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 3.7 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1 5.0 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.0 5.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.9 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 3.1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.6 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 6.5 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 2.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.8 GO:0019894 kinesin binding(GO:0019894)
0.0 0.5 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.6 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.8 GO:0042165 neurotransmitter binding(GO:0042165)
0.0 0.9 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.0 1.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 5.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 2.4 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 1.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 9.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.8 32.3 PID IL23 PATHWAY IL23-mediated signaling events
0.7 12.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.4 5.9 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.4 6.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.4 16.4 PID AURORA A PATHWAY Aurora A signaling
0.3 8.2 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 10.6 PID NECTIN PATHWAY Nectin adhesion pathway
0.3 11.4 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.3 7.6 PID CD40 PATHWAY CD40/CD40L signaling
0.3 17.3 PID BCR 5PATHWAY BCR signaling pathway
0.2 4.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.2 10.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.2 9.8 PID PLK1 PATHWAY PLK1 signaling events
0.2 7.5 PID RHOA PATHWAY RhoA signaling pathway
0.2 4.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 4.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 1.9 PID ARF 3PATHWAY Arf1 pathway
0.1 4.4 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 2.5 PID REELIN PATHWAY Reelin signaling pathway
0.1 4.7 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 2.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 1.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.7 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 2.3 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 2.2 PID BMP PATHWAY BMP receptor signaling
0.0 2.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 7.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.1 PID P53 REGULATION PATHWAY p53 pathway
0.0 5.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 18.8 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
1.7 21.7 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.9 9.7 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.8 7.6 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.8 11.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.8 17.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.7 25.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.7 49.4 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.7 4.8 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.7 10.6 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.6 6.7 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.6 7.3 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.6 9.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.6 9.0 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.6 17.8 REACTOME KINESINS Genes involved in Kinesins
0.5 15.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.5 9.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.5 5.9 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.4 5.9 REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.4 5.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.4 5.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.4 18.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.4 7.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.4 17.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.4 15.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 16.6 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.3 7.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3 3.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.3 7.1 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.3 49.0 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.2 2.3 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.2 9.0 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.2 7.2 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 3.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 7.6 REACTOME UNFOLDED PROTEIN RESPONSE Genes involved in Unfolded Protein Response
0.2 4.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 3.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 8.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 8.7 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.1 2.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 4.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 13.9 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 12.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 2.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 2.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 5.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 2.1 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 4.4 REACTOME TRANSLATION Genes involved in Translation
0.1 2.5 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.1 0.6 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 4.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.1 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.0 0.6 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D