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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zic4

Z-value: 1.01

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Transcription factors associated with Zic4

Gene Symbol Gene ID Gene Info
Zic4
ENSRNOG00000014871 Zic family member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zic4rn6_v1_chr8_+_98755104_987551040.632.2e-37Click!

Activity profile of Zic4 motif

Sorted Z-values of Zic4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_24923128 69.15 ENSRNOT00000044087
Pde8b
phosphodiesterase 8B
chr3_-_148428494 38.43 ENSRNOT00000011350
Dusp15
dual specificity phosphatase 15
chr3_-_148428288 32.70 ENSRNOT00000072663
Dusp15
dual specificity phosphatase 15
chr5_+_156876706 31.08 ENSRNOT00000021864
Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr9_+_82120059 31.06 ENSRNOT00000057368
Cdk5r2
cyclin-dependent kinase 5 regulatory subunit 2
chr10_-_91047177 31.02 ENSRNOT00000003986
C1ql1
complement C1q like 1
chr1_+_266953139 29.18 ENSRNOT00000054696
Neurl1
neuralized E3 ubiquitin protein ligase 1
chr5_-_40237591 27.57 ENSRNOT00000011393
Fut9
fucosyltransferase 9
chr19_-_9801942 25.87 ENSRNOT00000051414
ENSRNOT00000017494
Ndrg4
NDRG family member 4
chr8_-_36760742 23.67 ENSRNOT00000017307
Ddx25
DEAD-box helicase 25
chr17_-_10208360 22.95 ENSRNOT00000087397
Unc5a
unc-5 netrin receptor A
chr10_+_80790168 21.98 ENSRNOT00000073315
ENSRNOT00000075163
Car10
carbonic anhydrase 10
chr7_+_140788987 21.79 ENSRNOT00000086611
Kcnh3
potassium voltage-gated channel subfamily H member 3
chr1_+_84470829 21.74 ENSRNOT00000025472
Ttc9b
tetratricopeptide repeat domain 9B
chr1_-_212549477 21.32 ENSRNOT00000024765
Caly
calcyon neuron-specific vesicular protein
chr5_+_123905166 20.93 ENSRNOT00000082021
Dab1
DAB1, reelin adaptor protein
chr12_+_36694960 20.81 ENSRNOT00000064276
ENSRNOT00000001299
Scarb1
scavenger receptor class B, member 1
chr17_+_9109731 19.32 ENSRNOT00000016009
Cxcl14
C-X-C motif chemokine ligand 14
chrX_-_157312028 18.98 ENSRNOT00000077979
Atp2b3
ATPase plasma membrane Ca2+ transporting 3
chrX_-_82986051 18.57 ENSRNOT00000077587
Hdx
highly divergent homeobox
chr2_+_149214265 18.01 ENSRNOT00000084020
Med12l
mediator complex subunit 12-like
chr7_-_107009330 17.59 ENSRNOT00000074573
Kcnq3
potassium voltage-gated channel subfamily Q member 3
chr10_-_92008082 17.16 ENSRNOT00000006361
Nsf
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
chr1_-_112811936 17.15 ENSRNOT00000093339
Gabrg3
gamma-aminobutyric acid type A receptor gamma 3 subunit
chr19_+_20607507 16.78 ENSRNOT00000000011
Cbln1
cerebellin 1 precursor
chr13_+_110920830 16.49 ENSRNOT00000077014
ENSRNOT00000076362
Kcnh1
potassium voltage-gated channel subfamily H member 1
chr3_+_3310954 16.47 ENSRNOT00000061773
Kcnt1
potassium sodium-activated channel subfamily T member 1
chr1_-_216663720 16.33 ENSRNOT00000078944
ENSRNOT00000077409
Cdkn1c
cyclin-dependent kinase inhibitor 1C
chr8_-_103190243 15.62 ENSRNOT00000075305
Chst2
carbohydrate sulfotransferase 2
chr2_-_211207465 15.44 ENSRNOT00000027263
Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2
chrX_-_136807885 15.35 ENSRNOT00000010325
Igsf1
immunoglobulin superfamily, member 1
chr1_+_266952561 15.16 ENSRNOT00000076452
Neurl1
neuralized E3 ubiquitin protein ligase 1
chr19_-_15431274 14.66 ENSRNOT00000022285
ENSRNOT00000048470
Slc6a2
solute carrier family 6 member 2
chr13_-_51076165 14.50 ENSRNOT00000004602
Adora1
adenosine A1 receptor
chr19_-_43596801 13.93 ENSRNOT00000025625
Fa2h
fatty acid 2-hydroxylase
chr10_-_40953651 13.79 ENSRNOT00000063889
Glra1
glycine receptor, alpha 1
chr1_-_199270627 13.75 ENSRNOT00000026063
Stx1b
syntaxin 1B
chr3_+_112916217 13.25 ENSRNOT00000030065
Tmem62
transmembrane protein 62
chr3_-_2803574 12.72 ENSRNOT00000040995
RGD1560470
similar to Gene model 996
chr16_+_26739389 12.52 ENSRNOT00000047223
Klhl2
kelch-like family member 2
chr5_-_88629491 12.37 ENSRNOT00000058906
Tle1
transducin like enhancer of split 1
chr16_+_74886719 11.32 ENSRNOT00000089265
Atp7b
ATPase copper transporting beta
chr5_+_135962911 10.78 ENSRNOT00000087353
Ptch2
patched 2
chr1_-_84491466 10.66 ENSRNOT00000034609
Map3k10
mitogen activated protein kinase kinase kinase 10
chr20_-_1984737 10.59 ENSRNOT00000040232
ENSRNOT00000051634
ENSRNOT00000079445
Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
chr10_-_40953467 10.22 ENSRNOT00000092189
Glra1
glycine receptor, alpha 1
chr20_-_3822754 10.07 ENSRNOT00000000541
ENSRNOT00000077357
Slc39a7
solute carrier family 39 member 7
chr4_+_132137793 10.04 ENSRNOT00000014455
Gpr27
G protein-coupled receptor 27
chr1_-_78997869 9.89 ENSRNOT00000023490
Hif3a
hypoxia inducible factor 3, alpha subunit
chr11_+_75434197 9.70 ENSRNOT00000032569
Mb21d2
Mab-21 domain containing 2
chr17_-_31535172 9.51 ENSRNOT00000023914
Bphl
biphenyl hydrolase like
chr13_+_71107465 9.14 ENSRNOT00000003239
Rgs8
regulator of G-protein signaling 8
chr16_+_10267482 8.92 ENSRNOT00000085255
Gdf2
growth differentiation factor 2
chr7_-_124620703 8.80 ENSRNOT00000017727
Scube1
signal peptide, CUB domain and EGF like domain containing 1
chr2_-_26438790 8.79 ENSRNOT00000035017
Iqgap2
IQ motif containing GTPase activating protein 2
chr1_+_226435979 8.52 ENSRNOT00000048704
ENSRNOT00000036232
ENSRNOT00000035576
ENSRNOT00000036180
ENSRNOT00000036168
ENSRNOT00000047964
ENSRNOT00000036283
ENSRNOT00000007429
Syt7
synaptotagmin 7
chr5_-_150323063 8.36 ENSRNOT00000014084
Oprd1
opioid receptor, delta 1
chr10_+_48240127 7.75 ENSRNOT00000080682
Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr1_+_219348721 7.44 ENSRNOT00000025084
Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr6_-_6842758 7.21 ENSRNOT00000006094
Kcng3
potassium voltage-gated channel modifier subfamily G member 3
chr20_-_31598118 7.06 ENSRNOT00000046537
Col13a1
collagen type XIII alpha 1 chain
chr8_+_117246376 6.98 ENSRNOT00000074493
Ccdc71
coiled-coil domain containing 71
chr17_-_9695292 6.94 ENSRNOT00000036162
Prr7
proline rich 7 (synaptic)
chr10_-_109840047 6.75 ENSRNOT00000054947
Notum
NOTUM, palmitoleoyl-protein carboxylesterase
chr12_+_25036605 6.19 ENSRNOT00000001996
ENSRNOT00000084427
Limk1
LIM domain kinase 1
chr2_+_95008311 6.09 ENSRNOT00000077270
Tpd52
tumor protein D52
chr5_-_142845116 5.96 ENSRNOT00000065105
RGD1559909
RGD1559909
chr2_+_95008477 5.88 ENSRNOT00000015327
Tpd52
tumor protein D52
chr7_-_139254149 5.70 ENSRNOT00000078644
Rapgef3
Rap guanine nucleotide exchange factor 3
chr6_+_33885495 5.62 ENSRNOT00000086633
Sdc1
syndecan 1
chr16_-_20686317 5.48 ENSRNOT00000060097
Crlf1
cytokine receptor-like factor 1
chr16_+_59988603 5.26 ENSRNOT00000015176
Cldn23
claudin 23
chr8_+_45797315 5.23 ENSRNOT00000059997
AABR07070046.1

chr5_-_28131133 5.21 ENSRNOT00000067331
Slc26a7
solute carrier family 26 member 7
chr1_-_221605400 5.03 ENSRNOT00000028542
Ppp2r5b
protein phosphatase 2, regulatory subunit B', beta
chr1_-_165967069 4.86 ENSRNOT00000089359
Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr10_+_48240330 4.85 ENSRNOT00000057798
Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr3_+_175885894 4.57 ENSRNOT00000039780
Ntsr1
neurotensin receptor 1
chr17_-_52569036 4.46 ENSRNOT00000019396
Gli3
GLI family zinc finger 3
chr5_-_74190991 4.46 ENSRNOT00000090366
Epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr7_-_117786872 4.44 ENSRNOT00000030517
Lrrc24
leucine rich repeat containing 24
chr5_-_144479306 4.02 ENSRNOT00000087697
Ago1
argonaute 1, RISC catalytic component
chr10_-_75270561 3.88 ENSRNOT00000012279
Dynll2
dynein light chain LC8-type 2
chr6_+_69950500 3.76 ENSRNOT00000049500
RGD1559629
similar to H+ ATP synthase
chr16_+_59197367 3.74 ENSRNOT00000014924
Dlc1
DLC1 Rho GTPase activating protein
chr6_-_126582034 3.69 ENSRNOT00000010656
ENSRNOT00000080829
Itpk1
inositol-tetrakisphosphate 1-kinase
chr3_+_147226004 3.57 ENSRNOT00000012765
Tmem74b
transmembrane protein 74B
chr19_+_39229754 3.39 ENSRNOT00000050612
Vps4a
vacuolar protein sorting 4 homolog A
chr5_-_28130803 3.38 ENSRNOT00000093186
Slc26a7
solute carrier family 26 member 7
chr5_-_173622645 3.27 ENSRNOT00000045678
Agrn
agrin
chr20_-_422464 3.27 ENSRNOT00000051646
Olr1673
olfactory receptor 1673
chr10_+_86950557 3.26 ENSRNOT00000014153
Igfbp4
insulin-like growth factor binding protein 4
chr18_+_3995921 3.17 ENSRNOT00000091424
Ttc39c
tetratricopeptide repeat domain 39C
chr4_-_113886994 3.05 ENSRNOT00000037333
Htra2
HtrA serine peptidase 2
chr6_+_104017607 2.84 ENSRNOT00000033378
Exd2
exonuclease 3'-5' domain containing 2
chr7_-_144960527 2.84 ENSRNOT00000086554
Zfp385a
zinc finger protein 385A
chr10_+_15485905 2.70 ENSRNOT00000027609
Tmem8a
transmembrane protein 8A
chr5_-_74191167 2.58 ENSRNOT00000088169
Epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr6_+_1657331 2.52 ENSRNOT00000049672
ENSRNOT00000079864
Qpct
glutaminyl-peptide cyclotransferase
chr14_-_84170301 2.52 ENSRNOT00000080413
Slc35e4
solute carrier family 35, member E4
chr10_-_13898855 2.42 ENSRNOT00000004249
Rab26
RAB26, member RAS oncogene family
chr3_+_151609602 2.41 ENSRNOT00000065052
Spag4
sperm associated antigen 4
chr5_+_147714163 2.33 ENSRNOT00000012663
Marcksl1
MARCKS-like 1
chr1_-_67390141 2.26 ENSRNOT00000025808
Sbk1
SH3 domain binding kinase 1
chr1_+_146037426 2.21 ENSRNOT00000055583
Mesdc2
mesoderm development candidate 2
chr7_+_12006710 2.16 ENSRNOT00000045421
Klf16
Kruppel-like factor 16
chr7_+_54031316 2.16 ENSRNOT00000039096
Bbs10
Bardet-Biedl syndrome 10
chr1_-_277827178 2.14 ENSRNOT00000084915
ENSRNOT00000073346
Afap1l2
actin filament associated protein 1-like 2
chr3_+_147585947 2.05 ENSRNOT00000006833
Scrt2
scratch family transcriptional repressor 2
chrX_-_14331486 2.03 ENSRNOT00000067603
Rpgr
retinitis pigmentosa GTPase regulator
chr1_+_197659187 1.68 ENSRNOT00000082228
LOC103690016
serine/threonine-protein kinase SBK1
chr13_-_105141030 1.64 ENSRNOT00000003313
Tgfb2
transforming growth factor, beta 2
chr4_+_49369296 1.62 ENSRNOT00000007822
Wnt16
wingless-type MMTV integration site family, member 16
chr3_-_163814799 1.44 ENSRNOT00000055127
Znfx1
zinc finger, NFX1-type containing 1
chr14_-_12387102 1.38 ENSRNOT00000038872
Bmp3
bone morphogenetic protein 3
chr1_+_41325462 1.35 ENSRNOT00000081017
ENSRNOT00000078494
ENSRNOT00000088168
Esr1
estrogen receptor 1
chr4_-_77747070 1.34 ENSRNOT00000009247
Zfp746
zinc finger protein 746
chr15_+_24254042 0.94 ENSRNOT00000092161
Fbxo34
F-box protein 34
chr2_-_154508641 0.85 ENSRNOT00000065346
RGD1565059
similar to hypothetical protein E130311K13
chr7_+_117963740 0.74 ENSRNOT00000075405
LOC108348189
COMM domain-containing protein 5
chr5_-_169167831 0.73 ENSRNOT00000012407
Phf13
PHD finger protein 13
chr3_+_73010786 0.26 ENSRNOT00000051010
Olr447
olfactory receptor 447
chr13_-_48284990 0.23 ENSRNOT00000086928
Srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr1_+_204861566 0.18 ENSRNOT00000023214
Fam175b
family with sequence similarity 175, member B
chr14_+_81362618 0.15 ENSRNOT00000017386
Mfsd10
major facilitator superfamily domain containing 10
chr20_-_7397448 0.15 ENSRNOT00000059426
LOC294154
similar to chromosome 6 open reading frame 106 isoform a
chr7_+_116943057 0.09 ENSRNOT00000056527
Tigd5
tigger transposable element derived 5

Network of associatons between targets according to the STRING database.

First level regulatory network of Zic4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
13.8 69.2 GO:0035106 operant conditioning(GO:0035106)
7.8 31.1 GO:0021586 pons maturation(GO:0021586)
7.0 20.9 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
6.9 20.8 GO:0015920 lipopolysaccharide transport(GO:0015920)
6.2 31.0 GO:0061743 motor learning(GO:0061743)
5.5 38.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)
4.8 14.5 GO:0042323 regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) negative regulation of long term synaptic depression(GO:1900453)
4.6 13.8 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
4.3 17.2 GO:0035494 SNARE complex disassembly(GO:0035494)
3.8 23.0 GO:0033564 anterior/posterior axon guidance(GO:0033564)
3.8 11.3 GO:0015680 intracellular copper ion transport(GO:0015680)
3.3 10.0 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
3.2 19.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
3.2 44.3 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
3.1 15.4 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
3.0 24.0 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
2.9 25.9 GO:2001135 regulation of endocytic recycling(GO:2001135)
2.8 8.5 GO:1990926 short-term synaptic potentiation(GO:1990926)
2.7 16.3 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
2.4 19.0 GO:1990034 calcium ion export from cell(GO:1990034)
2.0 27.6 GO:0036065 fucosylation(GO:0036065)
1.8 10.6 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
1.6 9.8 GO:0032286 central nervous system myelin maintenance(GO:0032286)
1.5 4.6 GO:0089718 amino acid import across plasma membrane(GO:0089718)
1.4 5.6 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
1.2 7.3 GO:1904426 positive regulation of GTP binding(GO:1904426)
1.2 16.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.1 3.4 GO:0090611 multivesicular body assembly(GO:0036258) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of viral budding via host ESCRT complex(GO:1903774)
1.1 4.5 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
1.1 5.5 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
1.1 3.3 GO:0045887 positive regulation of synaptic growth at neuromuscular junction(GO:0045887) regulation of sodium:potassium-exchanging ATPase activity(GO:1903406) regulation of protein geranylgeranylation(GO:2000539) positive regulation of protein geranylgeranylation(GO:2000541)
1.0 4.0 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
1.0 17.6 GO:0060081 membrane hyperpolarization(GO:0060081)
1.0 14.7 GO:0051934 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934)
0.9 8.4 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.8 2.5 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.8 9.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.8 15.6 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.7 8.8 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.7 5.0 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.7 23.5 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.7 2.8 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.7 12.4 GO:2000811 negative regulation of anoikis(GO:2000811)
0.6 7.0 GO:0051547 regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.6 71.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.6 23.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.6 6.7 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.5 7.7 GO:0007256 activation of JNKK activity(GO:0007256)
0.5 8.6 GO:1902358 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.5 3.1 GO:1904923 regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.5 8.9 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.4 17.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.4 10.1 GO:0006882 cellular zinc ion homeostasis(GO:0006882)
0.3 1.4 GO:1990375 baculum development(GO:1990375)
0.3 2.4 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.2 3.7 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.2 6.2 GO:0051444 negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.2 3.3 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.2 1.6 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.2 3.7 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.1 31.1 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 2.2 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 4.9 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.1 2.1 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.1 7.4 GO:0015914 phospholipid transport(GO:0015914)
0.1 2.8 GO:0000729 DNA double-strand break processing(GO:0000729)
0.1 12.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.1 3.9 GO:0008038 neuron recognition(GO:0008038)
0.1 0.2 GO:0021815 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.1 4.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.7 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 9.9 GO:0071456 cellular response to hypoxia(GO:0071456)
0.1 2.0 GO:0042073 intraciliary transport(GO:0042073)
0.1 2.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 2.0 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 2.2 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.2 GO:0042891 antibiotic transport(GO:0042891)
0.0 1.4 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 5.5 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.2 GO:0070417 cellular response to cold(GO:0070417)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
10.4 31.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
7.8 31.0 GO:0044301 climbing fiber(GO:0044301)
3.5 10.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
1.9 5.7 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
1.8 5.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
1.4 13.8 GO:0048787 presynaptic active zone membrane(GO:0048787)
1.2 40.3 GO:0097440 apical dendrite(GO:0097440)
1.2 23.7 GO:0033391 chromatoid body(GO:0033391)
1.0 31.0 GO:0030673 axolemma(GO:0030673)
0.9 32.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.9 8.5 GO:0032009 early phagosome(GO:0032009)
0.8 20.8 GO:0031528 microvillus membrane(GO:0031528)
0.8 41.2 GO:0034707 chloride channel complex(GO:0034707)
0.8 4.6 GO:0032280 symmetric synapse(GO:0032280)
0.7 17.6 GO:0033268 node of Ranvier(GO:0033268)
0.6 4.0 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.5 35.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.5 22.4 GO:0016592 mediator complex(GO:0016592)
0.5 3.4 GO:0090543 Flemming body(GO:0090543)
0.4 3.9 GO:0016461 unconventional myosin complex(GO:0016461)
0.4 11.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 8.4 GO:0032590 dendrite membrane(GO:0032590)
0.3 3.3 GO:0043083 synaptic cleft(GO:0043083)
0.3 17.2 GO:0005795 Golgi stack(GO:0005795)
0.3 3.1 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 8.8 GO:0031941 filamentous actin(GO:0031941)
0.2 29.6 GO:0031253 cell projection membrane(GO:0031253)
0.2 5.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 12.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 6.2 GO:0044295 axonal growth cone(GO:0044295)
0.1 28.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 1.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 19.6 GO:0005903 brush border(GO:0005903)
0.1 17.3 GO:0098791 trans-Golgi network(GO:0005802) Golgi subcompartment(GO:0098791)
0.1 12.3 GO:0005923 bicellular tight junction(GO:0005923)
0.1 8.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 14.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 54.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 2.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 2.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 2.4 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 0.2 GO:0070552 BRISC complex(GO:0070552)
0.0 2.1 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 24.0 GO:0030977 taurine binding(GO:0030977)
7.8 31.1 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
6.9 20.8 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
5.5 38.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
4.6 27.6 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
4.6 23.0 GO:0005042 netrin receptor activity(GO:0005042)
3.7 14.7 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
3.6 21.3 GO:0032051 clathrin light chain binding(GO:0032051)
3.0 54.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
2.9 14.5 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
2.7 10.7 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
2.6 10.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
2.6 15.6 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
2.3 11.3 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
2.2 15.4 GO:0034711 inhibin binding(GO:0034711)
1.4 8.4 GO:0004985 opioid receptor activity(GO:0004985)
1.3 71.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.2 7.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
1.2 16.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
1.1 4.6 GO:0016492 G-protein coupled neurotensin receptor activity(GO:0016492)
1.0 17.2 GO:0031748 D1 dopamine receptor binding(GO:0031748)
1.0 31.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.9 5.5 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.9 19.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.8 37.7 GO:0045182 translation regulator activity(GO:0045182)
0.7 17.1 GO:0004890 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.6 5.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.6 2.4 GO:0019002 GMP binding(GO:0019002)
0.6 8.8 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.6 8.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.6 16.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.6 2.8 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.5 19.3 GO:0008009 chemokine activity(GO:0008009)
0.5 3.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.4 22.3 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.4 1.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.4 3.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.4 3.7 GO:0051766 inositol trisphosphate kinase activity(GO:0051766)
0.3 10.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 23.7 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.3 13.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.3 4.0 GO:0035198 miRNA binding(GO:0035198)
0.3 13.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 7.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 10.3 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.2 3.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 3.7 GO:0017166 vinculin binding(GO:0017166)
0.2 8.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 4.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 2.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 9.9 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 2.5 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 3.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 2.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 9.5 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 13.9 GO:0020037 heme binding(GO:0020037)
0.1 2.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 5.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 6.2 GO:0031072 heat shock protein binding(GO:0031072)
0.1 0.2 GO:0042895 antibiotic transporter activity(GO:0042895)
0.0 7.1 GO:0008201 heparin binding(GO:0008201)
0.0 6.7 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 1.6 GO:0005109 frizzled binding(GO:0005109)
0.0 3.9 GO:0003774 motor activity(GO:0003774)
0.0 8.4 GO:0003779 actin binding(GO:0003779)
0.0 15.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 4.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 4.8 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 3.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0048365 Rac GTPase binding(GO:0048365)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 52.0 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.6 12.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.6 23.0 PID NETRIN PATHWAY Netrin-mediated signaling events
0.5 9.9 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.4 10.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.3 5.7 ST G ALPHA S PATHWAY G alpha s Pathway
0.3 5.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 8.9 PID ALK1 PATHWAY ALK1 signaling events
0.2 3.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.2 7.3 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.2 53.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 8.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 20.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 3.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 23.0 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
1.5 41.2 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
1.2 20.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.9 48.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.9 17.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.9 14.5 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.8 19.0 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.7 13.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.6 14.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.5 10.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.5 15.6 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.5 5.6 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.5 9.9 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.5 10.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.4 5.7 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.4 53.3 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.3 12.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 5.0 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.3 11.3 REACTOME ION CHANNEL TRANSPORT Genes involved in Ion channel transport
0.3 6.2 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.2 3.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 3.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 3.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 4.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 4.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 9.7 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 5.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 4.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.4 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4