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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zscan4c

Z-value: 0.61

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Transcription factors associated with Zscan4c

Gene Symbol Gene ID Gene Info

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zscan4frn6_v1_chr7_-_17859653_178596530.114.3e-02Click!

Activity profile of Zscan4c motif

Sorted Z-values of Zscan4c motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_44746549 26.75 ENSRNOT00000003841
Fam183b
family with sequence similarity 183, member B
chr7_-_140483693 22.19 ENSRNOT00000089060
Ddn
dendrin
chr10_+_27973681 18.04 ENSRNOT00000004970
Gabrb2
gamma-aminobutyric acid type A receptor beta 2 subunit
chr5_-_62621737 13.91 ENSRNOT00000011573
Gabbr2
gamma-aminobutyric acid type B receptor subunit 2
chr10_-_107539658 13.73 ENSRNOT00000089346
Rbfox3
RNA binding protein, fox-1 homolog 3
chr10_-_107539465 12.30 ENSRNOT00000004524
Rbfox3
RNA binding protein, fox-1 homolog 3
chr1_-_8751198 11.57 ENSRNOT00000030511
Adgrg6
adhesion G protein-coupled receptor G6
chr13_+_101181994 11.07 ENSRNOT00000052407
Susd4
sushi domain containing 4
chr6_+_92229686 10.72 ENSRNOT00000046085
Atl1
atlastin GTPase 1
chr2_-_154418920 10.27 ENSRNOT00000076326
Plch1
phospholipase C, eta 1
chr2_-_154418629 9.94 ENSRNOT00000076274
ENSRNOT00000076165
Plch1
phospholipase C, eta 1
chr9_+_16862248 9.85 ENSRNOT00000080104
ENSRNOT00000024824
Ttbk1
tau tubulin kinase 1
chr4_-_180234804 9.79 ENSRNOT00000070957
Bhlhe41
basic helix-loop-helix family, member e41
chr18_+_59748444 9.40 ENSRNOT00000024752
St8sia3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr15_+_108908607 9.24 ENSRNOT00000089455
Zic2
Zic family member 2
chr1_+_170262156 9.22 ENSRNOT00000024077
ENSRNOT00000085395
Cckbr
cholecystokinin B receptor
chr17_-_9791781 9.02 ENSRNOT00000090536
Rgs14
regulator of G-protein signaling 14
chr18_-_14016713 9.01 ENSRNOT00000041125
Nol4
nucleolar protein 4
chr2_+_239415046 8.44 ENSRNOT00000072196
Cxxc4
CXXC finger protein 4
chr1_-_239057732 7.36 ENSRNOT00000024775
Gda
guanine deaminase
chr8_-_62987182 7.29 ENSRNOT00000070885
Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr5_-_7941822 7.17 ENSRNOT00000079917
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr2_+_236625357 6.81 ENSRNOT00000081248
Papss1
3'-phosphoadenosine 5'-phosphosulfate synthase 1
chr12_+_31934343 6.61 ENSRNOT00000011181
Tmem132d
transmembrane protein 132D
chr17_-_9792007 6.05 ENSRNOT00000021596
Rgs14
regulator of G-protein signaling 14
chr4_-_727691 6.04 ENSRNOT00000008497
Shh
sonic hedgehog
chr1_+_87248489 5.76 ENSRNOT00000028091
Dpf1
double PHD fingers 1
chr1_+_247084228 5.66 ENSRNOT00000020475
Plpp6
phospholipid phosphatase 6
chr13_+_82369493 5.53 ENSRNOT00000003733
Sell
selectin L
chr4_-_114853868 5.49 ENSRNOT00000090828
Wdr54
WD repeat domain 54
chr15_-_52399074 5.08 ENSRNOT00000018440
Xpo7
exportin 7
chrX_+_135348436 4.68 ENSRNOT00000008868
Rab33a
RAB33A, member RAS oncogene family
chr1_-_265798167 4.47 ENSRNOT00000079483
Ldb1
LIM domain binding 1
chr19_+_51317425 4.36 ENSRNOT00000019298
Cdh13
cadherin 13
chr20_+_42966140 4.19 ENSRNOT00000000707
Marcks
myristoylated alanine rich protein kinase C substrate
chr17_-_77687456 3.94 ENSRNOT00000045765
ENSRNOT00000081645
Frmd4a
FERM domain containing 4A
chr5_+_133864798 3.68 ENSRNOT00000091977
Tal1
TAL bHLH transcription factor 1, erythroid differentiation factor
chrX_+_70438617 3.33 ENSRNOT00000076671
Arr3
arrestin 3
chr13_-_90022269 3.09 ENSRNOT00000035498
Ly9
lymphocyte antigen 9
chr3_+_138974871 2.98 ENSRNOT00000012524
Scp2d1
SCP2 sterol-binding domain containing 1
chr20_+_48335540 2.95 ENSRNOT00000000352
Cd24
CD24 molecule
chr3_-_107760550 2.63 ENSRNOT00000077091
ENSRNOT00000051638
Meis2
Meis homeobox 2
chr9_+_94879745 2.21 ENSRNOT00000080482
Atg16l1
autophagy related 16-like 1
chr14_-_12387102 2.12 ENSRNOT00000038872
Bmp3
bone morphogenetic protein 3
chr3_-_162872831 1.57 ENSRNOT00000008478
Sulf2
sulfatase 2
chr12_+_42097626 1.41 ENSRNOT00000001893
Tbx5
T-box 5
chr5_+_63781801 1.39 ENSRNOT00000008302
Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr3_+_55094637 1.37 ENSRNOT00000058763
Cers6
ceramide synthase 6
chr1_-_82610350 1.25 ENSRNOT00000028177
Cyp2s1
cytochrome P450, family 2, subfamily s, polypeptide 1
chr1_+_201499028 1.23 ENSRNOT00000027860
Htra1
HtrA serine peptidase 1
chr2_-_210550490 1.21 ENSRNOT00000081835
ENSRNOT00000025222
ENSRNOT00000086403
Csf1
colony stimulating factor 1
chr10_+_34692870 0.97 ENSRNOT00000048930
Olr1395
olfactory receptor 1395
chr1_-_188895223 0.75 ENSRNOT00000032796
Gpr139
G protein-coupled receptor 139
chr3_+_171832500 0.63 ENSRNOT00000007554
Vapb
VAMP associated protein B and C
chr13_+_60619309 0.50 ENSRNOT00000082129
AABR07021204.1

chr10_+_15191078 0.49 ENSRNOT00000026697
Wdr24
WD repeat domain 24
chr5_-_155258392 0.30 ENSRNOT00000017065
C1qc
complement C1q C chain
chr10_+_74910713 0.08 ENSRNOT00000091619
Hsf5
heat shock transcription factor 5

Network of associatons between targets according to the STRING database.

First level regulatory network of Zscan4c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.1 GO:0010070 zygote asymmetric cell division(GO:0010070)
3.7 11.1 GO:0045959 negative regulation of complement activation, classical pathway(GO:0045959)
3.1 9.4 GO:1990743 protein sialylation(GO:1990743)
2.3 9.2 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
2.0 6.0 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
1.5 7.4 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
1.5 7.4 GO:0046098 guanine metabolic process(GO:0046098)
1.5 4.4 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
1.3 18.0 GO:0071420 cellular response to histamine(GO:0071420)
1.2 3.7 GO:0045799 positive regulation of chromatin assembly or disassembly(GO:0045799)
1.2 11.6 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
1.1 4.5 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
1.0 3.0 GO:0002840 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840)
1.0 6.8 GO:0000103 sulfate assimilation(GO:0000103)
0.9 9.8 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.6 5.5 GO:0070543 response to linoleic acid(GO:0070543)
0.6 4.2 GO:1900020 activation of phospholipase D activity(GO:0031584) regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.5 1.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.4 1.2 GO:0097187 dentinogenesis(GO:0097187)
0.4 1.2 GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 13.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.4 2.2 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.3 1.4 GO:0032763 regulation of mast cell cytokine production(GO:0032763) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3 17.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3 1.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.3 3.1 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.2 11.3 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.2 9.9 GO:0021762 substantia nigra development(GO:0021762)
0.2 27.4 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.1 3.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 4.7 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.1 7.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 6.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 5.1 GO:0006611 protein export from nucleus(GO:0006611)
0.1 0.3 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 1.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 3.0 GO:0015914 phospholipid transport(GO:0015914)
0.0 2.6 GO:0008542 visual learning(GO:0008542)
0.0 2.1 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 1.4 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 3.3 GO:0007601 visual perception(GO:0007601)
0.0 0.4 GO:0032008 positive regulation of TOR signaling(GO:0032008)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
1.5 10.7 GO:0000137 Golgi cis cisterna(GO:0000137)
1.5 22.2 GO:0032591 dendritic spine membrane(GO:0032591)
1.0 4.2 GO:0044307 germinal vesicle(GO:0042585) dendritic branch(GO:0044307)
0.8 18.0 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.4 1.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.4 5.8 GO:0071565 nBAF complex(GO:0071565)
0.2 9.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 3.0 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 15.1 GO:0016605 PML body(GO:0016605)
0.1 26.0 GO:0043204 perikaryon(GO:0043204)
0.1 2.2 GO:0000421 autophagosome membrane(GO:0000421)
0.1 5.1 GO:0005643 nuclear pore(GO:0005643)
0.1 3.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 0.5 GO:0061700 GATOR2 complex(GO:0061700)
0.1 3.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.4 GO:0042629 mast cell granule(GO:0042629)
0.0 4.4 GO:0005901 caveola(GO:0005901)
0.0 0.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 3.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 23.5 GO:0009986 cell surface(GO:0009986)
0.0 5.9 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 20.2 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
3.5 13.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
3.1 9.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
2.3 6.8 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
1.4 9.8 GO:0043426 MRF binding(GO:0043426)
1.3 18.0 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
1.1 4.4 GO:0055100 adiponectin binding(GO:0055100)
1.0 15.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.8 3.3 GO:0002046 opsin binding(GO:0002046)
0.8 6.0 GO:0043237 laminin-1 binding(GO:0043237)
0.6 5.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.6 4.5 GO:0030274 LIM domain binding(GO:0030274)
0.4 1.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.4 1.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 11.6 GO:0043236 laminin binding(GO:0043236)
0.3 7.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3 7.4 GO:0019239 deaminase activity(GO:0019239)
0.2 5.5 GO:0051861 glycolipid binding(GO:0051861)
0.2 9.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 2.1 GO:0070700 BMP receptor binding(GO:0070700)
0.2 1.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 0.6 GO:0033149 FFAT motif binding(GO:0033149)
0.1 3.0 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 3.0 GO:0015248 sterol transporter activity(GO:0015248)
0.1 24.7 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 3.7 GO:0070888 E-box binding(GO:0070888)
0.1 9.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 4.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 24.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 8.4 GO:0030165 PDZ domain binding(GO:0030165)
0.1 15.4 GO:0003924 GTPase activity(GO:0003924)
0.0 1.2 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 9.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.8 GO:0008188 neuropeptide receptor activity(GO:0008188)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 6.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.2 8.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 7.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 9.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.3 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.4 ST GA12 PATHWAY G alpha 12 Pathway
0.0 2.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 18.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.7 7.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.6 13.9 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.6 9.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.5 6.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.4 4.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 9.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 4.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 5.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 6.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.2 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 3.0 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 4.0 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway