Results for ABF2
Z-value: 1.87
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Transcription factors associated with ABF2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ABF2
|
S000004676 | Mitochondrial DNA-binding protein |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YBR072W Show fit | 22.11 |
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells |
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| YAR053W Show fit | 18.81 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YAR060C Show fit | 14.52 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YMR107W Show fit | 11.90 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YKL163W Show fit | 11.60 |
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway |
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| YHR212C Show fit | 11.30 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
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| YDL204W Show fit | 10.63 |
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily |
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| YHR212W-A Show fit | 10.43 |
Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
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| YCR005C Show fit | 9.73 |
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors |
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| YAL062W Show fit | 9.60 |
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources |
Network of associatons between targets according to the STRING database.
First level regulatory network of ABF2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.7 | GO:0006457 | protein folding(GO:0006457) |
| 2.0 | 17.8 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 1.7 | 15.6 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
| 3.0 | 12.1 | GO:0046688 | response to copper ion(GO:0046688) |
| 2.7 | 10.8 | GO:0046323 | glucose import(GO:0046323) |
| 2.1 | 10.4 | GO:0043954 | cellular component maintenance(GO:0043954) |
| 0.0 | 10.1 | GO:0007005 | mitochondrion organization(GO:0007005) |
| 3.1 | 9.3 | GO:0030808 | regulation of cyclic nucleotide metabolic process(GO:0030799) regulation of cyclic nucleotide biosynthetic process(GO:0030802) regulation of nucleotide biosynthetic process(GO:0030808) regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of purine nucleotide biosynthetic process(GO:1900371) |
| 2.2 | 8.9 | GO:0006075 | (1->3)-beta-D-glucan biosynthetic process(GO:0006075) |
| 2.9 | 8.8 | GO:0043335 | protein unfolding(GO:0043335) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.2 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.0 | 16.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 14.1 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 2.3 | 9.3 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 2.2 | 8.9 | GO:0000148 | 1,3-beta-D-glucan synthase complex(GO:0000148) |
| 0.1 | 8.4 | GO:0000324 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 0.2 | 7.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.5 | 7.4 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.2 | 6.5 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 1.2 | 5.9 | GO:0072380 | ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 46.1 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.8 | 16.3 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.3 | 13.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 1.0 | 11.9 | GO:0022838 | substrate-specific channel activity(GO:0022838) |
| 1.9 | 11.6 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.5 | 11.6 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 3.7 | 11.0 | GO:0036440 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 0.7 | 10.5 | GO:0015293 | symporter activity(GO:0015293) |
| 0.5 | 10.0 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 3.0 | 8.9 | GO:0003843 | 1,3-beta-D-glucan synthase activity(GO:0003843) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 146.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.9 | 3.7 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 0.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 0.6 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 0.4 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 0.1 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 0.1 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 144.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.3 | 4.2 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 1.3 | 3.8 | REACTOME PI3K EVENTS IN ERBB2 SIGNALING | Genes involved in PI3K events in ERBB2 signaling |
| 0.3 | 3.0 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 1.0 | 2.9 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 1.5 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.3 | 1.0 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.2 | 1.0 | REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | Genes involved in Transmembrane transport of small molecules |
| 0.2 | 0.8 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |
| 0.2 | 0.6 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |