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Results for ABF2

Z-value: 1.87

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Transcription factors associated with ABF2

Gene Symbol Gene ID Gene Info
ABF2
S000004676 Mitochondrial DNA-binding protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ABF2YMR072W-0.723.7e-05Click!

Activity profile of ABF2 motif

Sorted Z-values of ABF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YBR072W 22.11
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YAR053W 18.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR060C 14.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR107W 11.90
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YKL163W 11.60
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YHR212C 11.30 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL204W 10.63
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YHR212W-A 10.43 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YCR005C 9.73
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YAL062W 9.60
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YOL081W 9.34
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YBR116C 9.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YER103W 9.33
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YJL116C 8.89
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YFL052W 8.63 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YMR306W 7.91
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL133C-A 7.54 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL012W 6.68
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YHR126C 6.55 Putative protein of unknown function; transcription dependent upon Azf1p
YPL240C 6.45
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YAL005C 6.32
SSA1
ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YKL038W 6.11
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YGR142W 6.05
BTN2
v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YHR054W-A 5.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2
YLL026W 5.90
HSP104
Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YHR055C 5.87
CUP1-2
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YHR053C 5.78
CUP1-1
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YDL210W 5.76
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YCR021C 5.73
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YKL221W 5.71
MCH2
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YJL144W 5.58 Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YLL053C 5.51 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YNL194C 5.41 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDL218W 5.27 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YFR049W 5.14
YMR31
Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
YMR013C 5.09
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YFR053C 5.03
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YGR144W 5.01
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YDR542W 4.99
PAU10
Hypothetical protein
YLL052C 4.97
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YHR145C 4.58 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL161W 4.55
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR393W 4.54
ERR1
Protein of unknown function, has similarity to enolases
YOL052C-A 4.52
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YJR078W 4.34
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YOR338W 4.32 Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen
YDR059C 4.30
UBC5
Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YLR122C 4.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YOR346W 4.18
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YER065C 4.06
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YMR280C 3.98
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YGR043C 3.96
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YOR235W 3.91
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YMR017W 3.84
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YEL070W 3.84
DSF1
Deletion suppressor of mpt5 mutation
YML047W-A 3.84 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLL039C 3.71
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YDR043C 3.65
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YHR096C 3.62
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YOR345C 3.62 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YLR123C 3.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YDR541C 3.47 Putative dihydrokaempferol 4-reductase
YNL077W 3.42
APJ1
Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR343C 3.42 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YBR117C 3.35
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YNR073C 3.31 Putative mannitol dehydrogenase
YLR216C 3.24
CPR6
Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YPL021W 3.23
ECM23
Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
YCL001W-B 3.23 Putative protein of unknown function; identified by homology
YDR342C 3.17
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YLR403W 3.15
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YLR402W 3.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR381W 3.10
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YBR047W 3.08
FMP23
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR020W-A 3.06 Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAL063C 3.05
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YLR217W 3.02 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6
YBR169C 2.98
SSE2
Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p
YDR258C 2.90
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YPR150W 2.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YOR391C 2.77
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YFL054C 2.76 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YAR050W 2.76
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YAR019W-A 2.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR019C 2.75
CDC15
Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YMR068W 2.72
AVO2
Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YLR124W 2.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR054C 2.66 Putative protein of unknown function
YGL045W 2.65
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YLR456W 2.63 Putative protein of unknown function; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YDL020C 2.62
RPN4
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
YHR092C 2.55
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YBR046C 2.54
ZTA1
Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
YOR383C 2.54
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YJR008W 2.53 Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source.
YKL217W 2.51
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YKR009C 2.50
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YNR069C 2.45
BSC5
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YDR102C 2.44 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YGL191W 2.41
COX13
Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YAL034C 2.36
FUN19
Non-essential protein of unknown function
YMR105C 2.33
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YGR250C 2.32 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR125W 2.30 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YML131W 2.30 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YMR141C 2.29 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLL060C 2.28
GTT2
Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YBR054W 2.26
YRO2
Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YNL318C 2.26
HXT14
Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL055C 2.25
THI20
Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p
YPL278C 2.25 Putative protein of unknown function; gene expression regulated by copper levels
YAR047C 2.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR014W 2.24
BUD22
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YKL107W 2.21 Putative protein of unknown function
YPR013C 2.21 Putative zinc finger protein; YPR013C is not an essential gene
YPL250C 2.20
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YNL036W 2.17
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YOR227W 2.17 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCL054W 2.13
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YFL051C 2.12 Putative protein of unknown function; YFL051C is not an essential gene
YKL067W 2.11
YNK1
Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YLR247C 2.08
IRC20
Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
YOR376W 2.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YDR103W 2.06
STE5
Pheromone-response scaffold protein; binds kinases Ste11p, Ste7p, and Fus3p to form a MAPK cascade complex that interacts with the plasma membrane, via a PH (pleckstrin homology) and PM/NLS domain, and with Ste4p-Ste18p, during signaling
YDR214W 2.04
AHA1
Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock
YPL262W 2.04
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YDR277C 2.04
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YMR165C 2.04
PAH1
Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
YGR211W 2.03
ZPR1
Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p)
YDR298C 1.98
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YDL181W 1.97
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YJR077C 1.97
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YJL130C 1.94
URA2
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YGL255W 1.91
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YBR145W 1.87
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YPR036W-A 1.85 Protein of unknown function; transcription is regulated by Pdr1p
YBL048W 1.84 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOR386W 1.83
PHR1
DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
YLR047C 1.83
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YOL078W 1.82
AVO1
Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YFL053W 1.82
DAK2
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YDL085W 1.80
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YOR020C 1.79
HSP10
Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES
YER111C 1.76
SWI4
DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
YPR006C 1.76
ICL2
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YDR453C 1.76
TSA2
Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YDR092W 1.75
UBC13
Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YDL113C 1.72
ATG20
Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
YIL146C 1.72
ECM37
Non-essential protein of unknown function
YDR473C 1.71
PRP3
Splicing factor, component of the U4/U6-U5 snRNP complex
YNL190W 1.70 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YLR111W 1.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL109W 1.68
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YNL274C 1.68
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFR057W 1.67 Putative protein of unknown function
YDR223W 1.65
CRF1
Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
YFR052C-A 1.64 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR007C 1.63
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YKR029C 1.63
SET3
Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains
YMR186W 1.58
HSC82
Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
YBL038W 1.58
MRPL16
Mitochondrial ribosomal protein of the large subunit
YPL216W 1.58 Putative protein of unknown function; YPL216W is not an essential gene
YGL096W 1.57
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YMR081C 1.53
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YPL183W-A 1.51
RTC6
Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome; null mutation suppresses cdc13-1 temperature sensitivity
YPR065W 1.51
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YGR065C 1.49
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YPL187W 1.49
MF(ALPHA)1
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
YAL067W-A 1.48 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YER047C 1.46
SAP1
Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
YOR005C 1.45
DNL4
DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
YKL141W 1.45
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YOR392W 1.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat
YFR040W 1.44
SAP155
Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p
YFR016C 1.41 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
YLR366W 1.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YHR102W 1.41
KIC1
Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body
YDR151C 1.40
CTH1
Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis
YPL013C 1.39
MRPS16
Mitochondrial ribosomal protein of the small subunit
YKR011C 1.39 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YBR295W 1.37
PCA1
Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function
YMR206W 1.37 Putative protein of unknown function; YMR206W is not an essential gene
YHR078W 1.37 High osmolarity-regulated gene of unknown function
YBR250W 1.37
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YFL003C 1.33
MSH4
Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
YNL282W 1.33
POP3
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YDR262W 1.33 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
YHL008C 1.33 Putative protein of unknown function, does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YCR026C 1.31
NPP1
Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation
YIL160C 1.31
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YMR257C 1.30
PET111
Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
YBL054W 1.29 Protein of unknown function involved in rRNA and ribosome biosynthesis
YPL166W 1.26
ATG29
Protein specifically required for autophagy; may function in autophagosome formation at the pre-autophagosomal structure in collaboration with other autophagy proteins
YNR001C 1.26
CIT1
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YBR182C 1.25
SMP1
Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors
YOL060C 1.25
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YMR118C 1.25 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YGR183C 1.22
QCR9
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YOL100W 1.22
PKH2
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YDR034C 1.22
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer

Network of associatons between targets according to the STRING database.

First level regulatory network of ABF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.3 GO:0030808 regulation of cyclic nucleotide metabolic process(GO:0030799) regulation of cyclic nucleotide biosynthetic process(GO:0030802) regulation of nucleotide biosynthetic process(GO:0030808) regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of purine nucleotide biosynthetic process(GO:1900371)
3.0 12.1 GO:0046688 response to copper ion(GO:0046688)
2.9 8.8 GO:0043335 protein unfolding(GO:0043335)
2.7 10.8 GO:0046323 glucose import(GO:0046323)
2.6 7.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
2.2 8.9 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
2.1 10.4 GO:0043954 cellular component maintenance(GO:0043954)
2.0 6.0 GO:0019676 ammonia assimilation cycle(GO:0019676)
2.0 17.8 GO:0006097 glyoxylate cycle(GO:0006097)
1.7 15.6 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
1.7 1.7 GO:0046487 glyoxylate metabolic process(GO:0046487)
1.7 6.7 GO:0015847 putrescine transport(GO:0015847)
1.4 4.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.3 7.7 GO:0000492 box C/D snoRNP assembly(GO:0000492)
1.2 3.7 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.9 3.6 GO:0006848 pyruvate transport(GO:0006848)
0.9 5.4 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.9 4.4 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.8 0.8 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.8 7.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.7 2.1 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.7 5.6 GO:0015891 siderophore transport(GO:0015891)
0.7 2.8 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.7 4.7 GO:0015758 glucose transport(GO:0015758)
0.7 2.7 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.7 7.3 GO:0042026 protein refolding(GO:0042026)
0.6 2.5 GO:0015976 carbon utilization(GO:0015976)
0.6 6.3 GO:0060962 regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060962)
0.6 4.2 GO:1902707 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.6 1.8 GO:0019629 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.6 1.7 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.6 1.1 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.6 5.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.5 7.8 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.5 1.0 GO:0006102 isocitrate metabolic process(GO:0006102)
0.5 1.9 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.5 8.0 GO:0000209 protein polyubiquitination(GO:0000209)
0.5 3.2 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.5 1.4 GO:0015691 cadmium ion transport(GO:0015691)
0.5 1.4 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.4 1.3 GO:0015888 thiamine transport(GO:0015888)
0.4 2.2 GO:0051180 vitamin transport(GO:0051180)
0.4 1.8 GO:0043462 regulation of ATPase activity(GO:0043462)
0.4 2.6 GO:0071467 cellular response to pH(GO:0071467)
0.4 4.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.4 2.0 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.4 2.4 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.4 1.6 GO:0006527 arginine catabolic process(GO:0006527)
0.4 1.5 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.4 1.1 GO:0006545 glycine biosynthetic process(GO:0006545)
0.4 4.8 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.4 5.1 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 26.7 GO:0006457 protein folding(GO:0006457)
0.3 1.0 GO:0000304 response to singlet oxygen(GO:0000304)
0.3 1.7 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.3 2.0 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.3 4.3 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.3 1.3 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.3 4.8 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.3 0.6 GO:0006013 mannose metabolic process(GO:0006013)
0.3 2.1 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.3 1.2 GO:2000282 regulation of cellular amino acid biosynthetic process(GO:2000282) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.3 2.9 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.3 0.3 GO:0034224 cellular response to zinc ion starvation(GO:0034224) regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation(GO:0034225)
0.3 7.0 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.3 0.3 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.3 1.1 GO:0000435 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.3 0.8 GO:0032006 regulation of TOR signaling(GO:0032006)
0.3 1.9 GO:0061013 regulation of mRNA catabolic process(GO:0061013)
0.3 0.8 GO:0090630 activation of GTPase activity(GO:0090630)
0.3 1.0 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.2 0.7 GO:0051596 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 1.4 GO:0046686 response to cadmium ion(GO:0046686)
0.2 2.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.2 2.0 GO:0006829 zinc II ion transport(GO:0006829)
0.2 0.7 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.2 0.6 GO:0033993 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.2 0.6 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.2 0.4 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.2 1.7 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.2 1.2 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.2 1.2 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.2 0.6 GO:0005993 trehalose catabolic process(GO:0005993)
0.2 0.6 GO:0034389 lipid particle organization(GO:0034389)
0.2 1.7 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.2 0.9 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.2 0.9 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.2 1.3 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.2 0.7 GO:0034508 centromere complex assembly(GO:0034508) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.2 0.7 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.2 0.2 GO:0018105 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.2 1.7 GO:0030952 establishment or maintenance of actin cytoskeleton polarity(GO:0030950) establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.2 1.7 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.2 0.7 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.2 0.8 GO:0016242 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.2 2.1 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.2 2.3 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.2 0.6 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021)
0.1 1.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 4.6 GO:0022900 electron transport chain(GO:0022900)
0.1 2.9 GO:0006096 glycolytic process(GO:0006096) nucleoside diphosphate phosphorylation(GO:0006165) ATP generation from ADP(GO:0006757)
0.1 0.3 GO:0034755 high-affinity iron ion transmembrane transport(GO:0006827) iron ion transmembrane transport(GO:0034755)
0.1 0.7 GO:0035376 sterol import(GO:0035376)
0.1 1.4 GO:0006817 phosphate ion transport(GO:0006817)
0.1 1.2 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.7 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 0.9 GO:0051322 anaphase(GO:0051322)
0.1 1.9 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.1 0.4 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.1 1.4 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 0.9 GO:0030100 regulation of endocytosis(GO:0030100)
0.1 0.7 GO:0006452 translational frameshifting(GO:0006452)
0.1 2.0 GO:0009267 cellular response to starvation(GO:0009267)
0.1 0.4 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.1 0.8 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.7 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.4 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.1 0.5 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.1 0.1 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.1 0.3 GO:0036257 multivesicular body organization(GO:0036257)
0.1 1.2 GO:0007118 budding cell apical bud growth(GO:0007118)
0.1 0.3 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054) negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 0.5 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 0.5 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.6 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.9 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.3 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.2 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.3 GO:0051099 positive regulation of binding(GO:0051099)
0.1 1.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 1.0 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 0.8 GO:0015893 drug transport(GO:0015893)
0.1 0.1 GO:0045033 peroxisome inheritance(GO:0045033)
0.1 0.2 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.1 0.6 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.1 GO:0043270 positive regulation of ion transport(GO:0043270)
0.1 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.2 GO:0006546 glycine catabolic process(GO:0006546)
0.1 0.2 GO:0043007 maintenance of rDNA(GO:0043007)
0.1 0.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 1.1 GO:0006986 response to unfolded protein(GO:0006986)
0.1 0.4 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 0.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.1 GO:0019748 secondary metabolic process(GO:0019748)
0.0 0.1 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.0 0.2 GO:0072417 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.0 0.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970) cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629) ER-associated misfolded protein catabolic process(GO:0071712) endoplasmic reticulum to cytosol transport(GO:1903513)
0.0 10.1 GO:0007005 mitochondrion organization(GO:0007005)
0.0 0.3 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.5 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.1 GO:0045117 azole transport(GO:0045117)
0.0 0.2 GO:0006826 iron ion transport(GO:0006826)
0.0 0.3 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.0 0.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.1 GO:0046461 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.1 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.0 0.2 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.0 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.2 GO:0009651 response to salt stress(GO:0009651)
0.0 0.1 GO:0019400 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.0 0.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.2 GO:0006312 mitotic recombination(GO:0006312)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
2.2 8.9 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
1.7 5.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.2 5.9 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.7 4.2 GO:0031932 TORC2 complex(GO:0031932)
0.7 2.0 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.6 1.2 GO:0032126 eisosome(GO:0032126)
0.5 5.9 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.5 3.0 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.5 1.5 GO:0032807 DNA ligase IV complex(GO:0032807)
0.5 7.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.4 1.8 GO:0033309 SBF transcription complex(GO:0033309)
0.4 1.3 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.4 1.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 1.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.4 1.1 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.4 3.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.3 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 0.7 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 2.9 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.3 0.9 GO:0070211 Snt2C complex(GO:0070211)
0.3 1.4 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) mitochondrial inner membrane protein insertion complex(GO:0042721) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.3 2.6 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 0.7 GO:0032389 MutLalpha complex(GO:0032389)
0.2 0.7 GO:0033255 SAS acetyltransferase complex(GO:0033255)
0.2 1.6 GO:0034967 Set3 complex(GO:0034967)
0.2 1.9 GO:0000795 synaptonemal complex(GO:0000795)
0.2 0.9 GO:0031901 early endosome membrane(GO:0031901)
0.2 3.5 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.2 14.1 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 6.5 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 0.6 GO:0070274 RES complex(GO:0070274)
0.2 1.2 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.2 0.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.2 7.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.9 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 0.6 GO:0034448 EGO complex(GO:0034448)
0.1 2.9 GO:0031201 SNARE complex(GO:0031201)
0.1 3.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 0.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.2 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 1.3 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 1.6 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 0.5 GO:0034657 GID complex(GO:0034657)
0.1 0.2 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 2.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.5 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 8.4 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 3.5 GO:0000502 proteasome complex(GO:0000502)
0.1 20.2 GO:0005886 plasma membrane(GO:0005886)
0.1 0.9 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.5 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 4.1 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.1 GO:0097526 U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 1.2 GO:0061645 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.0 16.8 GO:0005739 mitochondrion(GO:0005739)
0.0 0.1 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.0 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
3.0 8.9 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
2.2 6.7 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
1.9 11.6 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
1.7 5.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.5 6.0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.5 5.8 GO:0005537 mannose binding(GO:0005537)
1.2 7.3 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
1.2 4.8 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
1.2 4.7 GO:0004396 hexokinase activity(GO:0004396)
1.0 5.0 GO:0008198 ferrous iron binding(GO:0008198)
1.0 11.9 GO:0022838 substrate-specific channel activity(GO:0022838)
1.0 4.8 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.9 2.7 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.8 16.3 GO:0051087 chaperone binding(GO:0051087)
0.8 5.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.7 10.5 GO:0015293 symporter activity(GO:0015293)
0.7 6.2 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.7 2.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.7 46.1 GO:0051082 unfolded protein binding(GO:0051082)
0.7 4.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.6 1.9 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.6 2.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.5 2.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.5 2.1 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.5 10.0 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.5 2.0 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.5 1.4 GO:0048038 quinone binding(GO:0048038)
0.5 11.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.5 5.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5 2.3 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.4 1.3 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.4 3.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 1.6 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.4 2.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.4 1.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.4 1.5 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.3 2.7 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.3 3.2 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 1.6 GO:0016783 sulfurtransferase activity(GO:0016783)
0.3 0.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 0.9 GO:0032183 SUMO binding(GO:0032183)
0.3 13.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.3 2.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 2.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 1.6 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.2 0.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 0.7 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.2 1.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 2.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 1.1 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.2 1.3 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.2 1.3 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.2 0.6 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.2 1.0 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.2 1.0 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.2 0.6 GO:0035673 peptide-transporting ATPase activity(GO:0015440) oligopeptide transmembrane transporter activity(GO:0035673)
0.2 0.6 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.2 0.4 GO:0051183 vitamin transporter activity(GO:0051183)
0.2 1.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 0.9 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.2 0.4 GO:0072341 modified amino acid binding(GO:0072341)
0.2 0.7 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.2 2.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 3.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 1.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 1.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 0.5 GO:0031072 heat shock protein binding(GO:0031072)
0.2 0.7 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.2 2.1 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.2 1.5 GO:0035064 methylated histone binding(GO:0035064)
0.2 1.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2 1.4 GO:0072509 divalent inorganic cation transmembrane transporter activity(GO:0072509)
0.1 0.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.4 GO:0097027 cyclin binding(GO:0030332) ubiquitin-protein transferase activator activity(GO:0097027)
0.1 2.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.5 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 0.5 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 2.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 2.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.0 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.1 3.2 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 0.5 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 1.0 GO:0099600 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.1 0.6 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 1.1 GO:0045182 translation regulator activity(GO:0045182)
0.1 5.3 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.1 1.0 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.5 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.9 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.2 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 1.1 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.8 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.1 1.0 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 0.1 GO:0090484 drug transporter activity(GO:0090484)
0.1 0.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.5 GO:0005096 GTPase activator activity(GO:0005096)
0.1 0.8 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 0.6 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0017022 myosin binding(GO:0017022)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.2 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 7.1 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.0 0.2 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.0 0.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.3 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 0.5 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.3 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 0.3 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.3 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.6 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.0 0.4 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.2 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.2 GO:0005199 structural constituent of cell wall(GO:0005199)
0.0 0.3 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.0 0.1 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 0.7 PID NOTCH PATHWAY Notch signaling pathway
0.2 0.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 0.6 PID P73PATHWAY p73 transcription factor network
0.1 146.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
1.0 2.9 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 4.2 REACTOME DNA REPAIR Genes involved in DNA Repair
0.3 1.0 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.3 3.0 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.2 1.5 REACTOME MEIOSIS Genes involved in Meiosis
0.2 0.8 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.2 1.0 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.2 0.6 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 144.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.2 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation