Results for ACE2
Z-value: 2.52
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Transcription factors associated with ACE2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ACE2
|
S000004121 | Transcription factor required for septum destruction after cytokinesis |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YLR154W-B Show fit | 35.30 |
Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand |
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| YLR154W-A Show fit | 34.61 |
Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand |
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| YLR154C Show fit | 33.29 |
Ribonuclease H2 subunit, required for RNase H2 activity |
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| YER124C Show fit | 32.89 |
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall |
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| YFR055W Show fit | 32.75 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YDL055C Show fit | 30.16 |
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure |
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| YFR056C Show fit | 26.89 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YNL327W Show fit | 25.80 |
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner |
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| YNL066W Show fit | 19.57 |
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family |
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| YHR143W Show fit | 19.23 |
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP |
Network of associatons between targets according to the STRING database.
First level regulatory network of ACE2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 142.8 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 9.1 | 99.8 | GO:0007109 | obsolete cytokinesis, completion of separation(GO:0007109) |
| 5.1 | 35.7 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 10.9 | 32.8 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 10.1 | 30.2 | GO:0019673 | GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673) |
| 1.9 | 29.8 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.3 | 29.7 | GO:0051169 | nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169) |
| 2.0 | 23.4 | GO:0000917 | barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529) |
| 0.2 | 23.0 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 4.5 | 22.7 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 127.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.7 | 101.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 1.2 | 86.8 | GO:0005576 | extracellular region(GO:0005576) |
| 0.4 | 75.3 | GO:0005933 | cellular bud(GO:0005933) |
| 14.2 | 42.5 | GO:0030428 | cell septum(GO:0030428) |
| 11.9 | 35.7 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.3 | 34.0 | GO:0005840 | ribosome(GO:0005840) |
| 0.2 | 30.7 | GO:0005730 | nucleolus(GO:0005730) |
| 0.6 | 20.7 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.4 | 15.0 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 169.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.2 | 54.5 | GO:0019843 | rRNA binding(GO:0019843) |
| 2.9 | 52.0 | GO:0015926 | glucosidase activity(GO:0015926) |
| 2.2 | 38.7 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 8.9 | 35.7 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 5.6 | 33.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 10.1 | 30.2 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 7.5 | 29.9 | GO:0042973 | glucan endo-1,3-beta-D-glucosidase activity(GO:0042973) |
| 0.3 | 18.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 4.3 | 17.0 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 10.6 | PID SHP2 PATHWAY | SHP2 signaling |
| 1.8 | 5.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 2.5 | 2.5 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.7 | 2.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.4 | 1.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.6 | 1.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.4 | 1.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.6 | 1.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.4 | 1.2 | PID FGF PATHWAY | FGF signaling pathway |
| 0.9 | 0.9 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 47.3 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 3.5 | 10.6 | REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR | Genes involved in Downstream signaling of activated FGFR |
| 1.4 | 5.4 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 1.6 | 4.9 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.9 | 3.6 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.8 | 3.2 | REACTOME GPCR DOWNSTREAM SIGNALING | Genes involved in GPCR downstream signaling |
| 0.3 | 2.4 | REACTOME METABOLISM OF RNA | Genes involved in Metabolism of RNA |
| 0.2 | 1.8 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.4 | 1.7 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.2 | 1.7 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |