Results for ADR1
Z-value: 1.99
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Transcription factors associated with ADR1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ADR1
|
S000002624 | Carbon source-responsive zinc-finger transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YKL217W Show fit | 56.93 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YKR097W Show fit | 19.88 |
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
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| YAL054C Show fit | 16.63 |
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions |
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| YLR312C Show fit | 16.38 |
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity |
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| YMR107W Show fit | 15.09 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YPR001W Show fit | 14.84 |
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate |
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| YFR053C Show fit | 13.71 |
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p |
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| YGR146C Show fit | 13.70 |
Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation |
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| YCR010C Show fit | 13.18 |
Acetate transporter required for normal sporulation; phosphorylated in mitochondria |
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| YGR067C Show fit | 12.42 |
Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p |
Network of associatons between targets according to the STRING database.
First level regulatory network of ADR1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.4 | 61.7 | GO:0006848 | pyruvate transport(GO:0006848) |
| 1.1 | 32.0 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 9.5 | 28.6 | GO:0019626 | propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629) |
| 2.0 | 27.9 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
| 2.8 | 27.6 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 3.1 | 21.7 | GO:0006083 | acetate metabolic process(GO:0006083) |
| 1.1 | 19.1 | GO:0042724 | thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724) |
| 1.1 | 17.1 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 5.3 | 15.9 | GO:0009437 | amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437) |
| 0.9 | 15.3 | GO:0005978 | glycogen biosynthetic process(GO:0005978) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 216.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.7 | 38.9 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.5 | 22.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 1.6 | 19.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.4 | 19.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.5 | 12.0 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.5 | 11.0 | GO:0005628 | prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764) |
| 0.7 | 9.0 | GO:0005619 | ascospore wall(GO:0005619) |
| 0.3 | 7.3 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 1.2 | 7.2 | GO:0045239 | tricarboxylic acid cycle enzyme complex(GO:0045239) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.2 | 65.8 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 1.7 | 23.8 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 7.8 | 23.4 | GO:0004108 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 0.4 | 20.5 | GO:0001228 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 1.2 | 18.7 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.7 | 17.2 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 5.5 | 16.6 | GO:0016208 | AMP binding(GO:0016208) |
| 5.3 | 15.9 | GO:0016406 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 3.4 | 13.8 | GO:0004396 | hexokinase activity(GO:0004396) |
| 0.7 | 13.5 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 203.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 6.8 | 20.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.6 | 6.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.9 | 2.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.4 | 2.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.5 | 1.4 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.4 | 1.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 1.0 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.2 | 0.7 | PID FOXO PATHWAY | FoxO family signaling |
| 0.3 | 0.5 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 198.6 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 2.4 | 18.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 2.6 | 7.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 1.0 | 4.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 1.5 | 4.4 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.3 | 3.1 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 1.0 | 2.9 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.3 | 0.9 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.3 | 0.9 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.1 | 0.8 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |