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Results for ADR1

Z-value: 1.99

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Transcription factors associated with ADR1

Gene Symbol Gene ID Gene Info
ADR1
S000002624 Carbon source-responsive zinc-finger transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ADR1YDR216W0.911.1e-10Click!

Activity profile of ADR1 motif

Sorted Z-values of ADR1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YKL217W 56.93
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YKR097W 19.88
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YAL054C 16.63
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YLR312C 16.38
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YMR107W 15.09
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YPR001W 14.84
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YFR053C 13.71
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YGR146C 13.70 Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation
YCR010C 13.18
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YGR067C 12.42 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YOR343C 12.32 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YHR217C 12.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YAR053W 12.18 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL116C 11.75
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YOR348C 11.58
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YML089C 11.24 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YER084W 11.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR236C 11.07
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR100C 9.82
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YGR144W 9.82
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YIL057C 9.40 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YJL133C-A 9.35 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAR035W 9.06
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YJL045W 8.93 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YMR017W 8.82
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YER014C-A 8.75
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YLR327C 8.62
TMA10
Protein of unknown function that associates with ribosomes
YMR034C 8.53 Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
YAR060C 8.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR002W 8.26
PDH1
Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YKL065W-A 8.24 Putative protein of unknown function
YHR218W 7.81 Helicase-like protein encoded within the telomeric Y' element
YNL202W 7.75
SPS19
Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
YER065C 7.75
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YFL051C 7.70 Putative protein of unknown function; YFL051C is not an essential gene
YGR243W 7.51
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR267W 7.51
BOP2
Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YDR119W-A 7.50 Putative protein of unknown function
YAL039C 7.36
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YPR151C 7.35
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YMR304W 7.29
UBP15
Ubiquitin-specific protease that may play a role in ubiquitin precursor processing
YCR007C 7.22 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YGL062W 7.20
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YKL109W 7.07
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YHR096C 7.04
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YHR139C 7.02
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YLR174W 7.01
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YOR388C 6.92
FDH1
NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
YML042W 6.85
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YLR004C 6.73
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YML090W 6.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YFL052W 6.59 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YDR277C 6.54
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YCR005C 6.50
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YDR043C 6.41
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YFR017C 6.40 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YLR438W 6.36
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YOL060C 6.25
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YDR536W 5.97
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YER188C-A 5.96 Putative protein of unknown function
YER189W 5.92 Putative protein of unknown function
YFL030W 5.78
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YPR184W 5.68
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YHR212C 5.66 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR211W 5.62
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YLR023C 5.60
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YNR073C 5.58 Putative mannitol dehydrogenase
YPR006C 5.53
ICL2
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YDR342C 5.52
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YIL162W 5.51
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YGL205W 5.46
POX1
Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YLR437C-A 5.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YGR087C 5.35
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YOL084W 5.33
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YML091C 5.21
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YPR036W-A 5.10 Protein of unknown function; transcription is regulated by Pdr1p
YPR007C 5.10
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YHR212W-A 5.09 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR138C 5.05 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YNL014W 4.86
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YKR009C 4.84
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YOR383C 4.80
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YML054C 4.72
CYB2
Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YER015W 4.68
FAA2
Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids
YPL147W 4.66
PXA1
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YDL174C 4.56
DLD1
D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YFL011W 4.54
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YDR259C 4.54
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YKL026C 4.50
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YOR235W 4.46
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YEL070W 4.45
DSF1
Deletion suppressor of mpt5 mutation
YEL009C 4.42
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YEL008W 4.39 Hypothetical protein predicted to be involved in metabolism
YGR070W 4.39
ROM1
GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YDL215C 4.38
GDH2
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YOR389W 4.37 Putative protein of unknown function; expression regulated by copper levels
YHR033W 4.30 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YPR030W 4.27
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YDR231C 4.22
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YKL016C 4.20
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YPL262W 4.20
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YEL009C-A 4.20 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL192W 4.19
IME4
Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YDL210W 4.18
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YOR374W 4.18
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YGL193C 4.17 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YBR105C 4.11
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YLL029W 4.07
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YDR036C 4.03
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YOR382W 3.97
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YMR170C 3.95
ALD2
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YER190W 3.95
YRF1-2
Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation
YPR154W 3.95
PIN3
Protein that induces appearance of [PIN+] prion when overproduced
YKR034W 3.93
DAL80
Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YNL036W 3.90
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YLR122C 3.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YGR032W 3.86
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YPL186C 3.84
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YOR072W 3.78 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YGL215W 3.75
CLG1
Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
YLR356W 3.74 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YPL024W 3.73
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YGL033W 3.70
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YNL055C 3.69
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YPL026C 3.64
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YBR051W 3.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YDL246C 3.62
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YMR311C 3.61
GLC8
Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2
YMR035W 3.59
IMP2
Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
YJR038C 3.58 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR026W 3.58
ATH1
Acid trehalase required for utilization of extracellular trehalose
YLR366W 3.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YFL063W 3.57 Dubious open reading frame, based on available experimental and comparative sequence data
YDL223C 3.57
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YBR050C 3.54
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YMR280C 3.54
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YLL009C 3.54
COX17
Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase
YMR175W 3.46
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YFL064C 3.43 Putative protein of unknown function
YML131W 3.43 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YMR040W 3.41
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YPL185W 3.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YLR123C 3.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YOL082W 3.37
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YOL085W-A 3.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YBR145W 3.35
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YKL171W 3.35 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YBR255C-A 3.32 Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YOR178C 3.31
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YPL201C 3.28
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YBL078C 3.28
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YHR097C 3.23 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YNL305C 3.20 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YDL085W 3.19
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YNL274C 3.19
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR115W 3.17 Putative protein of unknown function
YBL033C 3.15
RIB1
GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YEL010W 3.14 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL049W 3.13
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YOR071C 3.08
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YLR365W 3.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YJR159W 3.07
SOR1
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YDR070C 3.02
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL171C 3.02
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YER187W 2.99 Putative protein of unknown function; induced in respiratory-deficient cells
YNL115C 2.98 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
YAL062W 2.97
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YIL146C 2.92
ECM37
Non-essential protein of unknown function
YKL187C 2.90 Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
YKL148C 2.89
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YDR232W 2.86
HEM1
5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YLL060C 2.84
GTT2
Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YOR072W-A 2.83 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YER103W 2.82
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YGR088W 2.81
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YDL214C 2.80
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YMR181C 2.78 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YNL242W 2.77
ATG2
Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the pre-autophagosomal structure and mitochondria
YAL034C 2.77
FUN19
Non-essential protein of unknown function
YHL032C 2.77
GUT1
Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
YGL191W 2.76
COX13
Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YOL081W 2.76
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YIL160C 2.76
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YOR120W 2.73
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YNL125C 2.72
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YDL079C 2.70
MRK1
Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YGL045W 2.68
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YLR164W 2.68 Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YOR346W 2.68
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YOL047C 2.67 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YNL200C 2.67 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR452W 2.66
PPN1
Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
YML133C 2.66 Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron
YIL055C 2.66 Putative protein of unknown function
YDR077W 2.66
SED1
Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
YHR095W 2.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLL019C 2.63
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YDR010C 2.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR145C 2.62 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL107C 2.62
PFK26
6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A

Network of associatons between targets according to the STRING database.

First level regulatory network of ADR1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.4 61.7 GO:0006848 pyruvate transport(GO:0006848)
9.5 28.6 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
5.3 15.9 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
4.6 13.7 GO:0015755 fructose transport(GO:0015755)
3.1 21.7 GO:0006083 acetate metabolic process(GO:0006083)
2.9 11.6 GO:0015804 neutral amino acid transport(GO:0015804)
2.8 27.6 GO:0046487 glyoxylate metabolic process(GO:0046487)
2.5 7.6 GO:0006545 glycine biosynthetic process(GO:0006545)
2.5 7.4 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
2.2 2.2 GO:0019395 fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
2.0 27.9 GO:0009062 fatty acid catabolic process(GO:0009062)
2.0 6.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
1.9 7.8 GO:0006527 arginine catabolic process(GO:0006527)
1.9 11.4 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.7 1.7 GO:0006011 UDP-glucose metabolic process(GO:0006011)
1.7 5.2 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.7 6.8 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
1.6 4.9 GO:0006538 glutamate catabolic process(GO:0006538)
1.6 6.3 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.5 4.6 GO:0005993 trehalose catabolic process(GO:0005993)
1.5 4.4 GO:0090630 activation of GTPase activity(GO:0090630)
1.5 1.5 GO:0009313 oligosaccharide catabolic process(GO:0009313)
1.4 4.3 GO:0015888 thiamine transport(GO:0015888)
1.4 6.9 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
1.3 4.0 GO:0051469 vesicle fusion with vacuole(GO:0051469)
1.3 3.9 GO:0015976 carbon utilization(GO:0015976)
1.3 3.9 GO:0010039 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
1.3 2.6 GO:0046323 glucose import(GO:0046323)
1.3 3.8 GO:0042126 nitrate metabolic process(GO:0042126) nitrate assimilation(GO:0042128)
1.3 6.3 GO:0005980 glycogen catabolic process(GO:0005980)
1.2 11.0 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.2 2.4 GO:0006102 isocitrate metabolic process(GO:0006102)
1.2 9.6 GO:0015891 siderophore transport(GO:0015891)
1.2 5.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.2 11.6 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
1.1 19.1 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
1.1 32.0 GO:0006094 gluconeogenesis(GO:0006094)
1.1 4.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
1.1 2.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.1 17.1 GO:0015718 monocarboxylic acid transport(GO:0015718)
1.0 5.2 GO:0015793 glycerol transport(GO:0015793)
1.0 5.1 GO:0044746 amino acid export(GO:0032973) amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
1.0 3.0 GO:0030814 regulation of cyclic nucleotide metabolic process(GO:0030799) regulation of cyclic nucleotide biosynthetic process(GO:0030802) regulation of nucleotide biosynthetic process(GO:0030808) regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of purine nucleotide biosynthetic process(GO:1900371)
1.0 1.0 GO:0006108 malate metabolic process(GO:0006108)
1.0 4.0 GO:0006598 polyamine catabolic process(GO:0006598)
1.0 4.9 GO:0000023 maltose metabolic process(GO:0000023)
1.0 1.0 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
1.0 4.8 GO:0016562 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.9 5.7 GO:0006089 lactate metabolic process(GO:0006089)
0.9 3.7 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.9 2.7 GO:0042843 D-xylose catabolic process(GO:0042843)
0.9 15.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.9 1.8 GO:0046058 cAMP metabolic process(GO:0046058)
0.9 3.5 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.8 3.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.8 1.6 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.8 1.6 GO:0032006 regulation of TOR signaling(GO:0032006)
0.8 1.6 GO:0046688 response to copper ion(GO:0046688)
0.8 3.2 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.8 6.2 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.8 9.1 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.8 2.3 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.7 3.6 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.7 10.3 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.7 4.1 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.7 3.4 GO:0044070 regulation of anion transport(GO:0044070)
0.7 4.6 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.7 11.9 GO:0007129 synapsis(GO:0007129)
0.7 3.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.7 10.4 GO:0006754 ATP biosynthetic process(GO:0006754)
0.6 9.7 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.6 2.6 GO:0051274 beta-glucan biosynthetic process(GO:0051274)
0.6 1.3 GO:0043335 protein unfolding(GO:0043335)
0.6 1.9 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.6 1.9 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.6 2.4 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.6 1.8 GO:0033499 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.6 1.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.6 2.9 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.6 2.9 GO:0006828 manganese ion transport(GO:0006828)
0.6 0.6 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.6 2.3 GO:0034764 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.6 1.1 GO:0051594 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.6 3.9 GO:0009746 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.5 11.2 GO:0016579 protein deubiquitination(GO:0016579)
0.5 0.5 GO:0006772 thiamine metabolic process(GO:0006772)
0.5 2.1 GO:0006546 glycine catabolic process(GO:0006546)
0.5 2.1 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.5 0.5 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.5 2.1 GO:0070988 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.5 0.5 GO:0043902 positive regulation of multi-organism process(GO:0043902)
0.5 1.5 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.5 3.0 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.5 2.0 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.5 2.0 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.5 1.9 GO:0046464 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.5 3.4 GO:0045332 phospholipid translocation(GO:0045332)
0.5 2.4 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.5 6.6 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.5 1.4 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.5 1.4 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.5 1.8 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.4 1.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.4 3.5 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.4 1.7 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324) age-dependent general metabolic decline(GO:0007571)
0.4 0.8 GO:0019627 urea metabolic process(GO:0019627)
0.4 0.8 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.4 1.3 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.4 2.5 GO:0009098 leucine biosynthetic process(GO:0009098)
0.4 4.9 GO:0046686 response to cadmium ion(GO:0046686)
0.4 0.4 GO:0032069 regulation of nuclease activity(GO:0032069) positive regulation of nuclease activity(GO:0032075)
0.4 14.2 GO:0070591 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.4 1.1 GO:0046113 nucleobase catabolic process(GO:0046113)
0.4 2.2 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.4 2.5 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.4 2.9 GO:0072348 sulfur compound transport(GO:0072348)
0.4 1.8 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.3 3.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.3 11.4 GO:0009060 aerobic respiration(GO:0009060)
0.3 4.5 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.3 3.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.3 2.2 GO:0061013 regulation of mRNA catabolic process(GO:0061013)
0.3 3.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.3 0.9 GO:0071398 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.3 2.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.3 3.6 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.3 0.9 GO:0015856 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.3 3.8 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.3 1.1 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.3 1.4 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.3 1.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 1.8 GO:0018345 protein palmitoylation(GO:0018345)
0.3 1.3 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.2 0.7 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.2 0.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 0.2 GO:0042148 strand invasion(GO:0042148)
0.2 2.1 GO:0051293 establishment of spindle localization(GO:0051293) spindle localization(GO:0051653)
0.2 0.9 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 1.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.2 0.2 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.2 0.2 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322)
0.2 0.4 GO:0000304 response to singlet oxygen(GO:0000304)
0.2 2.1 GO:0015893 drug transport(GO:0015893)
0.2 1.5 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.2 0.6 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.2 4.4 GO:0006312 mitotic recombination(GO:0006312)
0.2 1.0 GO:0018065 protein-cofactor linkage(GO:0018065)
0.2 1.0 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.2 2.4 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.2 1.6 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.2 1.2 GO:0031397 negative regulation of protein ubiquitination(GO:0031397) negative regulation of protein modification by small protein conjugation or removal(GO:1903321)
0.2 0.6 GO:0001111 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.2 0.4 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.2 0.6 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.2 0.6 GO:0030491 heteroduplex formation(GO:0030491)
0.2 1.7 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 0.7 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.2 0.4 GO:0000409 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.2 3.4 GO:0032258 CVT pathway(GO:0032258)
0.2 1.1 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.2 1.1 GO:0032447 protein urmylation(GO:0032447)
0.2 0.4 GO:0051098 regulation of binding(GO:0051098)
0.2 0.5 GO:0045894 regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001196) negative regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001198) negative regulation of mating-type specific transcription, DNA-templated(GO:0045894)
0.2 0.7 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.2 0.3 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.2 0.7 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.2 0.6 GO:0006279 premeiotic DNA replication(GO:0006279)
0.2 0.5 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 0.5 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.1 0.4 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.1 2.6 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.3 GO:0051180 vitamin transport(GO:0051180)
0.1 0.4 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 0.3 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 0.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.1 1.0 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 1.7 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 0.8 GO:0016233 telomere capping(GO:0016233)
0.1 0.8 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 1.0 GO:0030242 pexophagy(GO:0030242)
0.1 0.5 GO:0030100 regulation of endocytosis(GO:0030100)
0.1 0.2 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.1 0.2 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.1 0.7 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 1.1 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 2.7 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.1 0.4 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 0.1 GO:0035494 SNARE complex disassembly(GO:0035494)
0.1 0.5 GO:0051260 protein homooligomerization(GO:0051260)
0.1 1.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.3 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 3.1 GO:0000282 cellular bud site selection(GO:0000282) mitotic cytokinesis, site selection(GO:1902408)
0.1 1.2 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.5 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.1 0.3 GO:0035822 gene conversion(GO:0035822)
0.1 0.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.4 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 0.2 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.1 0.4 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.1 0.3 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.1 0.8 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.5 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 0.3 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 0.4 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 0.9 GO:0006476 protein deacetylation(GO:0006476) protein deacylation(GO:0035601) macromolecule deacylation(GO:0098732)
0.1 0.3 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 1.4 GO:0022900 electron transport chain(GO:0022900)
0.1 0.3 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.1 0.6 GO:0006119 oxidative phosphorylation(GO:0006119)
0.1 1.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.2 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.1 0.2 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.3 GO:0016241 regulation of macroautophagy(GO:0016241)
0.1 0.3 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 0.1 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 2.2 GO:0007031 peroxisome organization(GO:0007031)
0.1 0.2 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.1 0.7 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.5 GO:0060261 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 0.1 GO:0045895 positive regulation of mating-type specific transcription, DNA-templated(GO:0045895)
0.1 0.3 GO:1902532 negative regulation of intracellular signal transduction(GO:1902532)
0.1 0.1 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.1 0.2 GO:0015809 arginine transport(GO:0015809)
0.1 0.1 GO:0015851 nucleobase transport(GO:0015851)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.0 0.1 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712) DNA topological change(GO:0006265)
0.0 0.3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.2 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.2 GO:0019400 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.0 0.2 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.3 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.0 0.1 GO:0042407 cristae formation(GO:0042407)
0.0 0.2 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.0 0.3 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.0 GO:0045117 azole transport(GO:0045117)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:1904666 regulation of ubiquitin protein ligase activity(GO:1904666)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.0 GO:0090399 replicative senescence(GO:0090399)
0.0 0.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.1 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.1 GO:0071033 nuclear retention of pre-mRNA at the site of transcription(GO:0071033)
0.0 0.1 GO:0071850 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.0 0.2 GO:0006301 postreplication repair(GO:0006301)
0.0 0.0 GO:0042762 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of sulfur metabolic process(GO:0042762)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.6 19.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.4 4.3 GO:0031166 integral component of vacuolar membrane(GO:0031166)
1.4 4.2 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
1.2 3.7 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
1.2 7.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
1.2 3.6 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
1.2 3.6 GO:0046930 pore complex(GO:0046930)
1.2 5.8 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.1 4.4 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
1.0 7.1 GO:0034657 GID complex(GO:0034657)
1.0 2.9 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.8 6.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.8 3.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.7 4.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.7 2.9 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.7 2.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.7 38.9 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.7 9.0 GO:0005619 ascospore wall(GO:0005619)
0.6 1.3 GO:0032126 eisosome(GO:0032126)
0.5 1.1 GO:0030061 mitochondrial crista(GO:0030061)
0.5 12.0 GO:0070469 respiratory chain(GO:0070469)
0.5 22.0 GO:0031225 anchored component of membrane(GO:0031225)
0.5 11.0 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.4 2.6 GO:0034967 Set3 complex(GO:0034967)
0.4 0.8 GO:0001400 mating projection base(GO:0001400)
0.4 19.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.4 1.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 3.2 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.3 7.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.3 1.4 GO:0033551 monopolin complex(GO:0033551)
0.3 1.6 GO:0000795 synaptonemal complex(GO:0000795)
0.3 0.8 GO:0030870 Mre11 complex(GO:0030870)
0.3 216.4 GO:0005739 mitochondrion(GO:0005739)
0.3 0.8 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.3 0.8 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.2 1.1 GO:0031932 TORC2 complex(GO:0031932)
0.2 0.6 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.2 3.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 0.8 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 1.8 GO:0031011 Ino80 complex(GO:0031011)
0.2 1.7 GO:0005769 early endosome(GO:0005769)
0.2 0.7 GO:0000817 COMA complex(GO:0000817)
0.2 0.7 GO:0016587 Isw1 complex(GO:0016587)
0.2 1.0 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 0.7 GO:0033309 SBF transcription complex(GO:0033309)
0.2 1.3 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 1.1 GO:0000439 nucleotide-excision repair factor 3 complex(GO:0000112) core TFIIH complex(GO:0000439)
0.2 0.9 GO:0031499 TRAMP complex(GO:0031499)
0.1 0.6 GO:0032116 SMC loading complex(GO:0032116)
0.1 0.3 GO:0005775 vacuolar lumen(GO:0005775)
0.1 0.9 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 2.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.6 GO:0005869 dynactin complex(GO:0005869)
0.1 0.4 GO:0032176 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.1 0.6 GO:0032221 Rpd3S complex(GO:0032221)
0.1 0.7 GO:0008180 COP9 signalosome(GO:0008180)
0.1 2.3 GO:0016592 mediator complex(GO:0016592)
0.1 0.8 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.2 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.1 0.9 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.2 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 1.8 GO:0005811 lipid particle(GO:0005811)
0.1 1.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.2 GO:0031207 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.1 0.3 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 0.3 GO:0097196 Shu complex(GO:0097196)
0.1 0.5 GO:0097346 INO80-type complex(GO:0097346)
0.1 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.2 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.1 0.2 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 0.6 GO:0000942 condensed chromosome outer kinetochore(GO:0000940) condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 1.2 GO:0005770 late endosome(GO:0005770)
0.0 0.2 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 1.3 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0030869 RENT complex(GO:0030869)
0.0 0.6 GO:0016586 RSC complex(GO:0016586)
0.0 0.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0032545 CURI complex(GO:0032545)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.1 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.1 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.0 0.0 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
13.2 65.8 GO:0015295 solute:proton symporter activity(GO:0015295)
7.8 23.4 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
5.5 16.6 GO:0016208 AMP binding(GO:0016208)
5.3 15.9 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
3.4 13.8 GO:0004396 hexokinase activity(GO:0004396)
2.9 8.6 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
2.8 11.1 GO:0005537 mannose binding(GO:0005537)
2.5 7.5 GO:0016289 CoA hydrolase activity(GO:0016289)
2.3 9.3 GO:0004457 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
2.2 11.2 GO:0008198 ferrous iron binding(GO:0008198)
1.9 11.2 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.9 13.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.7 23.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
1.7 5.0 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.6 6.3 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.5 6.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.5 4.6 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
1.5 4.5 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.5 4.4 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
1.4 2.8 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.4 2.8 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
1.3 7.6 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.2 18.7 GO:0016831 carboxy-lyase activity(GO:0016831)
1.2 2.4 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
1.2 3.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
1.2 3.6 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
1.2 3.6 GO:0022829 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
1.2 4.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.2 5.8 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.1 4.6 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.9 5.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.9 7.7 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.8 0.8 GO:0004075 biotin carboxylase activity(GO:0004075)
0.8 5.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.8 8.8 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.8 2.3 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.8 2.3 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.8 8.3 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.8 8.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.7 17.2 GO:0016836 hydro-lyase activity(GO:0016836)
0.7 4.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.7 13.5 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.7 6.6 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.7 3.3 GO:0016530 metallochaperone activity(GO:0016530)
0.6 0.6 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.6 6.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.6 0.6 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.5 1.1 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.5 5.4 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.5 2.1 GO:0016642 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.5 1.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.5 6.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.5 0.5 GO:0032452 histone demethylase activity(GO:0032452)
0.5 9.2 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.5 1.9 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.5 1.4 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.5 3.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.5 6.3 GO:0008236 serine-type peptidase activity(GO:0008236)
0.5 2.7 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.4 20.5 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.4 2.2 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.4 7.5 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 2.2 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.4 2.1 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.4 1.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.4 2.1 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.4 6.5 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.4 1.2 GO:0015186 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.4 1.2 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.4 2.3 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.4 1.9 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.4 1.5 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.4 3.4 GO:0004177 aminopeptidase activity(GO:0004177)
0.4 1.1 GO:0005536 glucose binding(GO:0005536)
0.4 1.5 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.4 1.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.4 1.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 1.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.3 0.7 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.3 3.3 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 7.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.3 0.7 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.3 3.9 GO:0005199 structural constituent of cell wall(GO:0005199)
0.3 2.6 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.3 0.8 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.3 0.8 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.3 0.5 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.2 2.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 0.9 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 2.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.2 0.9 GO:0022821 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.2 1.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 0.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 3.4 GO:0005057 receptor signaling protein activity(GO:0005057)
0.2 0.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 3.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.2 0.2 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 1.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 0.8 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.2 2.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 0.4 GO:0001026 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.2 2.8 GO:0015616 DNA translocase activity(GO:0015616)
0.2 2.1 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.2 1.5 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 2.4 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.2 0.8 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.2 1.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 1.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 0.5 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.2 0.8 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.2 0.6 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.7 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.1 0.6 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 0.1 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H3-K9 specific)(GO:0032129) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.1 0.3 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.4 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 1.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.4 GO:0097617 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.1 1.0 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 10.3 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.4 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 2.6 GO:0019901 protein kinase binding(GO:0019901)
0.1 0.4 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 8.1 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.2 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.1 1.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 0.5 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.5 GO:0000149 SNARE binding(GO:0000149)
0.1 0.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.3 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 0.2 GO:0000150 recombinase activity(GO:0000150)
0.1 0.5 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.1 0.6 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.1 0.2 GO:0032183 SUMO binding(GO:0032183)
0.1 0.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 0.7 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.3 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 0.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 0.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.6 GO:0005507 copper ion binding(GO:0005507)
0.1 1.1 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.1 0.4 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.3 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 0.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 0.5 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.4 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 3.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.6 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.2 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.9 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.4 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.5 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.0 GO:0045118 azole transporter activity(GO:0045118)
0.0 0.3 GO:0022838 substrate-specific channel activity(GO:0022838)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 1.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.3 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.3 GO:0008173 RNA methyltransferase activity(GO:0008173)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 20.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.6 6.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.9 2.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.5 1.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4 1.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.4 2.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.3 1.0 PID ATF2 PATHWAY ATF-2 transcription factor network
0.3 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 0.7 PID FOXO PATHWAY FoxO family signaling
0.2 0.4 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 203.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 0.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.1 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
2.4 18.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
1.5 4.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
1.0 2.9 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
1.0 4.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.3 3.1 REACTOME MEIOSIS Genes involved in Meiosis
0.3 0.3 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.3 0.7 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.3 0.9 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 0.9 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.2 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 0.3 REACTOME ACTIVATED TLR4 SIGNALLING Genes involved in Activated TLR4 signalling
0.1 198.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 0.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.1 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.1 0.8 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 0.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.2 REACTOME TRANSCRIPTION Genes involved in Transcription
0.0 0.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.0 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules