Results for AFT1
Z-value: 0.88
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Transcription factors associated with AFT1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
AFT1
|
S000003039 | Transcription factor involved in iron utilization and homeostasis |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YOR383C Show fit | 13.45 |
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall |
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| YOR382W Show fit | 13.17 |
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall |
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| YDR536W Show fit | 7.21 |
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
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| YLR136C Show fit | 5.99 |
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis |
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| YEL065W Show fit | 5.32 |
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p |
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| YHL040C Show fit | 5.31 |
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores |
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| YLR205C Show fit | 5.24 |
ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1 |
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| YKL217W Show fit | 4.79 |
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose |
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| YAR053W Show fit | 4.36 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YER065C Show fit | 3.84 |
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose |
Network of associatons between targets according to the STRING database.
First level regulatory network of AFT1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 38.7 | GO:0015891 | siderophore transport(GO:0015891) |
| 0.5 | 12.6 | GO:0006879 | cellular iron ion homeostasis(GO:0006879) |
| 1.5 | 7.6 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.7 | 6.3 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 1.2 | 4.8 | GO:0006848 | pyruvate transport(GO:0006848) |
| 1.0 | 4.0 | GO:0046323 | glucose import(GO:0046323) |
| 0.1 | 3.8 | GO:0022900 | electron transport chain(GO:0022900) |
| 0.9 | 3.7 | GO:0000949 | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949) |
| 0.3 | 3.3 | GO:0015893 | drug transport(GO:0015893) |
| 0.4 | 2.7 | GO:0000501 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 25.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 12.9 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.0 | 11.6 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.1 | 8.6 | GO:0000329 | fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852) |
| 0.0 | 6.8 | GO:0005740 | mitochondrial envelope(GO:0005740) |
| 0.2 | 5.4 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 1.0 | 5.2 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.3 | 3.7 | GO:0005619 | ascospore wall(GO:0005619) |
| 0.4 | 3.3 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.2 | 2.5 | GO:0098797 | plasma membrane protein complex(GO:0098797) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 15.4 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 3.4 | 13.8 | GO:0042927 | siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927) |
| 0.1 | 7.0 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.7 | 6.2 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723) |
| 0.1 | 6.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.4 | 4.7 | GO:0015662 | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662) |
| 0.2 | 4.1 | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705) |
| 0.9 | 3.7 | GO:0004737 | pyruvate decarboxylase activity(GO:0004737) |
| 0.5 | 3.7 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.1 | 3.7 | GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.5 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.6 | 1.8 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.2 | 0.7 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.1 | 0.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 0.5 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 0.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 0.2 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 0.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 0.1 | PID EPHB FWD PATHWAY | EPHB forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.3 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.5 | 1.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 0.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 0.5 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.0 | 0.5 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.1 | 0.4 | REACTOME BIOLOGICAL OXIDATIONS | Genes involved in Biological oxidations |
| 0.1 | 0.3 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |
| 0.0 | 0.2 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 0.1 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.1 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |