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Results for AFT2

Z-value: 3.67

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Transcription factors associated with AFT2

Gene Symbol Gene ID Gene Info
AFT2
S000006123 Iron-regulated transcriptional activator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
AFT2YPL202C0.611.0e-03Click!

Activity profile of AFT2 motif

Sorted Z-values of AFT2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YOR382W 110.34
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YHR217C 103.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YHR218W 71.35 Helicase-like protein encoded within the telomeric Y' element
YFL063W 70.21 Dubious open reading frame, based on available experimental and comparative sequence data
YFL064C 61.71 Putative protein of unknown function
YFL062W 50.36
COS4
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YOR383C 38.35
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YDR536W 35.80
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YNL336W 34.96
COS1
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YNL339C 32.47
YRF1-6
Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YLR136C 32.36
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YJL089W 31.47
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YJL133C-A 29.35 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL250C 28.67
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YNL337W 27.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL217W 25.99
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YOR100C 25.81
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YMR013C 25.00
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YAR035W 24.73
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YLR004C 24.72
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YPL017C 21.22
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YHR033W 20.49 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YOR381W 20.44
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YAL062W 20.44
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YNL194C 20.33 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YML133C 18.16 Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron
YOL084W 17.84
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YCR021C 17.78
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YDL222C 17.25
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YML132W 16.49
COS3
Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YOL082W 16.35
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YMR107W 15.65
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YOL052C-A 15.62
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YMR206W 15.12 Putative protein of unknown function; YMR206W is not an essential gene
YCR005C 14.28
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YDR034C 13.98
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YEL070W 13.83
DSF1
Deletion suppressor of mpt5 mutation
YIL057C 13.75 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YDL210W 13.38
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YIL055C 13.36 Putative protein of unknown function
YHL040C 13.32
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YMR056C 13.28
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YFL024C 13.14
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YLR205C 13.02
HMX1
ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1
YGR258C 12.80
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YBR296C 12.70
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YIL047C 12.58
SYG1
Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YAR053W 12.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL065W 12.28
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YMR014W 12.04
BUD22
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YBR117C 11.93
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YHR212C 11.78 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR186C 11.69 Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YHR211W 11.68
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YOR152C 11.52 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YOR348C 11.41
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YDR269C 11.32 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR032W 11.27
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YAR023C 11.14 Putative integral membrane protein, member of DUP240 gene family
YHR139C 10.99
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YJR095W 10.84
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YGR146C 10.81 Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR270W 10.56
CCC2
Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases
YHR212W-A 10.56 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR043C 10.43
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YCR025C 10.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YEL008W 10.38 Hypothetical protein predicted to be involved in metabolism
YOL060C 10.34
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YAR050W 10.30
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YAL067C 10.30
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YHL046W-A 10.01 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL144C 10.00 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YFL019C 10.00 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YER158C 9.86 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YEL009C 9.53
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YAR060C 9.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR213C 9.23
CRR1
Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
YHL047C 9.10
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YFL034W 9.08 Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
YKL103C 9.05
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YOR343C 8.87 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YBR047W 8.80
FMP23
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL258W-A 8.78 Putative protein of unknown function
YPR192W 8.64
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YGL146C 8.63 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YKL221W 8.55
MCH2
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YKL065W-A 8.48 Putative protein of unknown function
YDR441C 8.47
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YGL072C 8.45 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YKL112W 8.45
ABF1
DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
YAR047C 8.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR035C 8.43
PDX3
Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YEL074W 8.39 Hypothetical protein
YOL085W-A 8.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YIL099W 8.30
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YGL083W 8.25
SCY1
Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
YEL060C 8.23
PRB1
Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YOR384W 8.13
FRE5
Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR231C 8.05
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YKL177W 8.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YMR175W 7.99
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YGL255W 7.96
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YMR034C 7.92 Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
YPR015C 7.76 Putative protein of unknown function
YPR007C 7.74
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YMR194C-B 7.73 Putative protein of unknown function
YNL142W 7.65
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YOR387C 7.62 Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YLR047C 7.60
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YKL023W 7.54 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR036C 7.54
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YPL222C-A 7.48 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YMR081C 7.47
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YER065C 7.36
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YAL039C 7.34
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YBR046C 7.34
ZTA1
Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
YLR327C 7.31
TMA10
Protein of unknown function that associates with ribosomes
YKL102C 7.16 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YDR259C 7.15
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YHL035C 7.04
VMR1
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies
YDR542W 7.02
PAU10
Hypothetical protein
YMR017W 6.99
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YEL075C 6.90 Putative protein of unknown function
YBR072W 6.83
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YPL156C 6.82
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YBR292C 6.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YEL030C-A 6.74 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHL036W 6.71
MUP3
Low affinity methionine permease, similar to Mup1p
YPL018W 6.68
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YKL044W 6.64 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL020C 6.61
PAU5
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YPL024W 6.59
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YOR346W 6.54
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YNL237W 6.53
YTP1
Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
YNR069C 6.52
BSC5
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YGR065C 6.45
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YGR144W 6.42
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YPR036W-A 6.41 Protein of unknown function; transcription is regulated by Pdr1p
YML089C 6.39 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YDR442W 6.38 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL001W-A 6.34 Putative protein of unknown function; YCL001W-A is not an essential gene
YLR356W 6.32 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YDR178W 6.28
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YGR067C 6.26 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YIL125W 6.25
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YLR030W 6.20 Putative protein of unknown function
YGL084C 6.19
GUP1
Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport
YLR438W 6.16
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YOR378W 6.14 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YIL101C 6.14
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YKL178C 6.08
STE3
Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YFL021W 6.07
GAT1
Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YHR210C 5.95 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YOR345C 5.95 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YAL063C 5.93
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YHR096C 5.91
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YPL240C 5.90
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YBL075C 5.87
SSA3
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YHL032C 5.83
GUT1
Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
YGR039W 5.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YGR221C 5.76
TOS2
Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p
YHR050W 5.70
SMF2
Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
YPL282C 5.68
PAU22
Hypothetical protein
YLR402W 5.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR232W 5.60
HEM1
5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YLR214W 5.57
FRE1
Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
YAR069C 5.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR196W 5.48 Putative maltose activator
YPL026C 5.46
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YDR453C 5.45
TSA2
Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YHR049C-A 5.43 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR403W 5.41
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YDR301W 5.31
CFT1
RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF
YAR070C 5.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL146C 5.30
ECM37
Non-essential protein of unknown function
YCL001W-B 5.30 Putative protein of unknown function; identified by homology
YOR186C-A 5.29 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPR184W 5.26
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YLR437C-A 5.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YLR326W 5.21 Hypothetical protein
YBL099W 5.08
ATP1
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YLR425W 5.07
TUS1
Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
YLR377C 5.06
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YNL143C 5.03 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR103W 5.02
PRE2
Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
YJL094C 4.99
KHA1
Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
YPL135W 4.97
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YEL030W 4.96
ECM10
Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations
YGR066C 4.95 Putative protein of unknown function
YKR011C 4.92 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YMR250W 4.91
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YOR328W 4.84
PDR10
ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
YPL058C 4.83
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YNL277W 4.83
MET2
L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway
YLR390W-A 4.82
CCW14
Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
YJR005C-A 4.82 Putative protein of unknown function, originally identified as a syntenic homolog of an Ashbya gossypii gene
YDR541C 4.76 Putative dihydrokaempferol 4-reductase
YER014C-A 4.70
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YKR103W 4.67
NFT1
Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
YKL031W 4.65 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species

Network of associatons between targets according to the STRING database.

First level regulatory network of AFT2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
25.0 200.2 GO:0015891 siderophore transport(GO:0015891)
10.5 31.5 GO:0035948 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
8.2 24.7 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
8.0 39.8 GO:0015793 glycerol transport(GO:0015793)
6.5 26.0 GO:0006848 pyruvate transport(GO:0006848)
6.4 19.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
5.6 16.7 GO:0019676 ammonia assimilation cycle(GO:0019676)
5.5 16.5 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
5.2 31.4 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
4.0 4.0 GO:0015688 iron chelate transport(GO:0015688)
3.6 14.5 GO:0015804 neutral amino acid transport(GO:0015804)
3.6 10.8 GO:0015740 C4-dicarboxylate transport(GO:0015740)
3.2 9.6 GO:0006527 arginine catabolic process(GO:0006527)
3.2 9.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
2.9 11.6 GO:0015847 putrescine transport(GO:0015847)
2.8 11.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
2.8 22.4 GO:0006097 glyoxylate cycle(GO:0006097)
2.7 13.6 GO:0005980 glycogen catabolic process(GO:0005980)
2.6 10.5 GO:1901678 iron coordination entity transport(GO:1901678)
2.6 15.6 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
2.6 12.8 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
2.5 12.5 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
2.5 7.4 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
2.4 7.3 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
2.3 7.0 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
2.3 16.0 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
2.2 28.7 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
2.2 19.7 GO:0006826 iron ion transport(GO:0006826)
2.1 6.3 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
2.0 10.2 GO:0051099 positive regulation of binding(GO:0051099)
2.0 6.1 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
2.0 5.9 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
2.0 7.9 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
2.0 7.8 GO:0006598 polyamine catabolic process(GO:0006598)
1.9 13.6 GO:0016239 positive regulation of macroautophagy(GO:0016239)
1.9 5.7 GO:0015888 thiamine transport(GO:0015888)
1.9 26.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
1.8 1.8 GO:0043419 urea metabolic process(GO:0019627) urea catabolic process(GO:0043419)
1.6 4.9 GO:0006538 glutamate catabolic process(GO:0006538)
1.6 3.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.5 4.6 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
1.5 4.6 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
1.5 4.5 GO:0006108 malate metabolic process(GO:0006108)
1.5 5.9 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
1.5 4.4 GO:0015755 fructose transport(GO:0015755)
1.4 11.3 GO:0006829 zinc II ion transport(GO:0006829)
1.4 7.0 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.4 4.2 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
1.3 6.5 GO:0051180 vitamin transport(GO:0051180)
1.3 31.0 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
1.3 10.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
1.3 6.3 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
1.2 16.0 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
1.2 32.2 GO:0055072 iron ion homeostasis(GO:0055072)
1.2 3.5 GO:0006740 NADPH regeneration(GO:0006740)
1.2 3.5 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
1.1 6.9 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
1.1 3.4 GO:0071248 cellular response to metal ion(GO:0071248)
1.1 1.1 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
1.1 4.5 GO:0001324 age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324)
1.1 7.9 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
1.1 1.1 GO:0071361 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
1.1 6.6 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
1.1 5.5 GO:0046058 cAMP metabolic process(GO:0046058)
1.1 5.4 GO:0001666 response to hypoxia(GO:0001666)
1.0 6.2 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
1.0 9.9 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
1.0 5.9 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.9 2.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.9 6.6 GO:0000023 maltose metabolic process(GO:0000023)
0.9 8.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.9 2.8 GO:0006545 glycine biosynthetic process(GO:0006545)
0.9 2.7 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.9 2.7 GO:0043335 protein unfolding(GO:0043335)
0.9 0.9 GO:0046688 response to copper ion(GO:0046688)
0.9 3.4 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.9 2.6 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.9 4.3 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.8 5.1 GO:0015802 basic amino acid transport(GO:0015802)
0.8 2.4 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.8 2.4 GO:0009107 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.8 21.2 GO:0098656 anion transmembrane transport(GO:0098656)
0.8 1.6 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
0.8 10.7 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.8 2.3 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.7 2.2 GO:0072369 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.7 2.2 GO:0046174 polyol catabolic process(GO:0046174)
0.7 9.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.7 2.8 GO:0051352 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.7 8.7 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.7 3.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.6 13.6 GO:0032258 CVT pathway(GO:0032258)
0.6 5.7 GO:0070987 error-free translesion synthesis(GO:0070987)
0.6 1.8 GO:0051260 protein homooligomerization(GO:0051260)
0.6 1.8 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.6 6.7 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.6 4.2 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.6 6.6 GO:0015893 drug transport(GO:0015893)
0.6 3.0 GO:0006083 acetate metabolic process(GO:0006083)
0.6 5.3 GO:0045332 phospholipid translocation(GO:0045332)
0.6 5.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.6 3.5 GO:0006089 lactate metabolic process(GO:0006089)
0.6 6.2 GO:0042026 protein refolding(GO:0042026)
0.5 1.0 GO:0051259 protein oligomerization(GO:0051259)
0.5 1.5 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.5 4.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 2.5 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.5 0.5 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.5 5.4 GO:0043486 histone exchange(GO:0043486)
0.5 6.7 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.5 7.1 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.5 4.6 GO:0009743 response to carbohydrate(GO:0009743)
0.5 31.3 GO:0030437 ascospore formation(GO:0030437) cell development(GO:0048468)
0.5 2.7 GO:0006279 premeiotic DNA replication(GO:0006279)
0.4 2.7 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.4 0.4 GO:0072366 regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.4 1.6 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.4 2.0 GO:0043954 cellular component maintenance(GO:0043954)
0.4 17.2 GO:0009060 aerobic respiration(GO:0009060)
0.4 4.1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.4 4.1 GO:0022900 electron transport chain(GO:0022900)
0.4 5.1 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.4 2.2 GO:0046686 response to cadmium ion(GO:0046686)
0.4 2.5 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.4 3.6 GO:0009092 homoserine metabolic process(GO:0009092)
0.4 3.2 GO:0051181 cofactor transport(GO:0051181)
0.4 3.5 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.4 1.1 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.3 2.8 GO:0000755 cytogamy(GO:0000755)
0.3 7.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.3 4.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.3 0.3 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.3 9.7 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.3 2.3 GO:0030100 regulation of endocytosis(GO:0030100)
0.3 2.5 GO:0031167 rRNA methylation(GO:0031167)
0.3 0.9 GO:0032186 cellular bud neck septin ring organization(GO:0032186)
0.3 3.3 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.3 1.2 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.3 0.9 GO:0031507 heterochromatin assembly(GO:0031507)
0.3 3.1 GO:0007129 synapsis(GO:0007129)
0.3 1.6 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.2 0.2 GO:0070726 cell wall assembly(GO:0070726)
0.2 0.5 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.2 1.8 GO:0034476 U5 snRNA 3'-end processing(GO:0034476)
0.2 0.9 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.2 1.3 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.2 2.1 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.2 1.9 GO:0006553 lysine metabolic process(GO:0006553) lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 4.5 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.2 1.2 GO:0010677 negative regulation of cellular carbohydrate metabolic process(GO:0010677) negative regulation of gluconeogenesis(GO:0045721) negative regulation of carbohydrate metabolic process(GO:0045912)
0.2 0.6 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.2 1.0 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 0.8 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.2 0.6 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.2 0.4 GO:0046185 aldehyde catabolic process(GO:0046185)
0.2 0.7 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 0.4 GO:0060195 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 0.4 GO:0006531 aspartate metabolic process(GO:0006531)
0.2 0.5 GO:0043171 peptide catabolic process(GO:0043171)
0.2 1.9 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.2 0.2 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.2 1.0 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.2 1.5 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2 0.5 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.2 0.8 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.2 1.4 GO:0006526 arginine biosynthetic process(GO:0006526)
0.2 1.4 GO:0006865 amino acid transport(GO:0006865)
0.2 1.7 GO:0016925 protein sumoylation(GO:0016925)
0.1 1.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 0.3 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.1 0.3 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.8 GO:0019932 calcium-mediated signaling(GO:0019722) second-messenger-mediated signaling(GO:0019932)
0.1 1.8 GO:0043633 polyadenylation-dependent RNA catabolic process(GO:0043633)
0.1 3.9 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 1.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.7 GO:0051322 anaphase(GO:0051322)
0.1 0.4 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 2.3 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.4 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.1 0.6 GO:0031134 sister chromatid biorientation(GO:0031134)
0.1 0.1 GO:0034204 lipid translocation(GO:0034204) regulation of membrane lipid distribution(GO:0097035)
0.1 0.5 GO:0045033 peroxisome inheritance(GO:0045033)
0.1 0.7 GO:0006641 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.1 0.6 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 3.5 GO:0030435 sporulation resulting in formation of a cellular spore(GO:0030435)
0.1 0.3 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.1 0.7 GO:0023057 negative regulation of signal transduction(GO:0009968) negative regulation of signaling(GO:0023057)
0.1 1.1 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.6 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.1 1.1 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.2 GO:0008272 sulfate transport(GO:0008272)
0.1 3.2 GO:0007124 pseudohyphal growth(GO:0007124)
0.1 0.3 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.1 0.5 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.4 GO:0051318 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318)
0.1 1.4 GO:0007117 budding cell bud growth(GO:0007117)
0.1 0.2 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.1 0.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.2 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.1 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.1 0.4 GO:0006816 calcium ion transport(GO:0006816)
0.1 1.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 0.3 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.3 GO:0051294 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.0 0.1 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.0 0.2 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.0 0.3 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 1.1 GO:0006475 internal protein amino acid acetylation(GO:0006475) histone acetylation(GO:0016573) internal peptidyl-lysine acetylation(GO:0018393) peptidyl-lysine acetylation(GO:0018394)
0.0 0.2 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.9 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0 0.5 GO:0048278 vesicle docking(GO:0048278)
0.0 0.3 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.2 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.0 GO:0043096 purine nucleobase salvage(GO:0043096)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 158.8 GO:0031225 anchored component of membrane(GO:0031225)
3.1 9.2 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
2.9 17.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
2.8 11.3 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
2.4 12.2 GO:0005640 nuclear outer membrane(GO:0005640)
2.4 14.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
2.4 16.9 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
2.2 6.6 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
2.1 6.3 GO:0045240 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
2.1 26.9 GO:0005619 ascospore wall(GO:0005619)
1.5 7.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
1.4 7.0 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.3 9.3 GO:0033101 cellular bud membrane(GO:0033101)
1.3 5.2 GO:0070469 respiratory chain(GO:0070469)
1.1 3.4 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
1.1 10.0 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
1.1 31.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
1.0 4.2 GO:0031901 early endosome membrane(GO:0031901)
1.0 188.7 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.9 0.9 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.9 3.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.8 7.6 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.7 5.0 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.7 6.8 GO:0098797 plasma membrane protein complex(GO:0098797)
0.6 1.9 GO:0032807 DNA ligase IV complex(GO:0032807)
0.6 2.5 GO:0000817 COMA complex(GO:0000817)
0.6 110.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.6 4.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.5 10.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.5 2.7 GO:0005769 early endosome(GO:0005769)
0.5 8.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.5 2.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.5 27.4 GO:0010008 endosome membrane(GO:0010008)
0.5 3.4 GO:0016272 prefoldin complex(GO:0016272)
0.5 0.9 GO:0043291 RAVE complex(GO:0043291)
0.5 7.7 GO:0005774 vacuolar membrane(GO:0005774)
0.4 1.3 GO:0005770 late endosome(GO:0005770)
0.4 0.8 GO:0001400 mating projection base(GO:0001400)
0.4 5.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.4 2.6 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.3 1.0 GO:0005784 Sec61 translocon complex(GO:0005784)
0.3 11.0 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.3 4.5 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.3 94.6 GO:0005886 plasma membrane(GO:0005886)
0.3 0.3 GO:0034099 luminal surveillance complex(GO:0034099)
0.3 17.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 15.7 GO:0005874 microtubule(GO:0005874)
0.2 1.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 7.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 1.8 GO:0005940 septin ring(GO:0005940)
0.2 2.0 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 1.3 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.2 3.1 GO:0000124 SAGA complex(GO:0000124)
0.2 1.4 GO:0034657 GID complex(GO:0034657)
0.2 2.3 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.2 2.8 GO:0005682 U5 snRNP(GO:0005682)
0.2 1.0 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 0.5 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.2 1.0 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 0.6 GO:0030869 RENT complex(GO:0030869)
0.2 6.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.5 GO:0000974 Prp19 complex(GO:0000974)
0.1 3.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 2.8 GO:0016592 mediator complex(GO:0016592)
0.1 2.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 1.7 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.6 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.4 GO:0032221 Rpd3S complex(GO:0032221)
0.1 1.2 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.2 GO:0000417 HIR complex(GO:0000417)
0.1 0.2 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.3 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 1.2 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
15.0 75.2 GO:0015295 solute:proton symporter activity(GO:0015295)
9.7 38.7 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
8.2 24.7 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
7.9 31.4 GO:0005537 mannose binding(GO:0005537)
5.7 17.0 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
5.5 49.9 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
4.2 16.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
3.8 11.3 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
3.7 11.1 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
3.4 3.4 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
3.0 12.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
2.7 10.8 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
2.5 7.5 GO:0016289 CoA hydrolase activity(GO:0016289)
2.5 9.8 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
2.4 29.0 GO:0022838 substrate-specific channel activity(GO:0022838)
2.4 23.7 GO:0015293 symporter activity(GO:0015293)
2.3 21.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
2.2 4.4 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
2.2 10.9 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
2.1 8.4 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
2.1 10.5 GO:0008198 ferrous iron binding(GO:0008198)
2.1 6.3 GO:0048038 quinone binding(GO:0048038)
2.1 27.0 GO:0015297 antiporter activity(GO:0015297)
2.0 6.1 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
2.0 11.9 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
1.9 5.7 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
1.9 9.4 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
1.8 11.0 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.8 12.8 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
1.8 7.2 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
1.7 8.3 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.5 9.0 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.5 5.8 GO:0004396 hexokinase activity(GO:0004396)
1.4 11.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.4 12.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.3 8.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
1.3 62.1 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.3 3.8 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.2 3.7 GO:0016880 AMP binding(GO:0016208) acid-ammonia (or amide) ligase activity(GO:0016880)
1.2 14.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.1 4.6 GO:0016898 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
1.1 4.5 GO:0016615 malate dehydrogenase activity(GO:0016615)
1.0 4.2 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
1.0 6.2 GO:0000400 four-way junction DNA binding(GO:0000400)
1.0 8.2 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
1.0 3.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.9 9.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.9 6.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.9 5.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.9 1.7 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.9 4.3 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.8 4.1 GO:0016530 metallochaperone activity(GO:0016530)
0.8 9.8 GO:0005507 copper ion binding(GO:0005507)
0.8 7.0 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.8 3.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.8 6.9 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.8 7.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.7 22.6 GO:0003678 DNA helicase activity(GO:0003678)
0.7 17.9 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.7 3.4 GO:0008236 serine-type peptidase activity(GO:0008236)
0.6 1.3 GO:0005536 glucose binding(GO:0005536)
0.6 2.4 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.6 7.1 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.6 2.9 GO:0008171 O-methyltransferase activity(GO:0008171)
0.6 1.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.6 1.7 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.6 8.8 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.5 2.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.5 1.6 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.5 3.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.5 2.1 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.5 4.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.5 2.5 GO:0016783 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.5 8.4 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.5 27.4 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.5 1.4 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.5 3.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.5 1.8 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.5 1.8 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.5 6.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.4 0.9 GO:0004180 carboxypeptidase activity(GO:0004180)
0.4 0.4 GO:0061134 peptidase regulator activity(GO:0061134)
0.4 4.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.4 0.8 GO:0019903 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.4 0.8 GO:0005102 receptor binding(GO:0005102)
0.4 8.5 GO:0003684 damaged DNA binding(GO:0003684)
0.4 1.1 GO:0019203 carbohydrate phosphatase activity(GO:0019203)
0.4 4.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 2.9 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.4 2.9 GO:0051184 cofactor transporter activity(GO:0051184)
0.4 4.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.4 11.9 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.3 1.7 GO:0019789 SUMO transferase activity(GO:0019789)
0.3 0.7 GO:0042171 lysophosphatidic acid acyltransferase activity(GO:0042171)
0.3 1.3 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.3 2.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 3.4 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.3 1.5 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.3 0.9 GO:0001047 core promoter binding(GO:0001047)
0.3 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.3 19.6 GO:0051082 unfolded protein binding(GO:0051082)
0.3 0.8 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.3 0.8 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.3 0.8 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.3 0.8 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.2 2.0 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 0.7 GO:0016872 intramolecular lyase activity(GO:0016872)
0.2 0.7 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.2 1.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 1.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.2 0.4 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.2 1.8 GO:0045182 translation regulator activity(GO:0045182)
0.2 3.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.2 1.0 GO:0035064 methylated histone binding(GO:0035064)
0.2 6.2 GO:0043492 ATPase activity, coupled to movement of substances(GO:0043492)
0.2 1.4 GO:0008374 O-acyltransferase activity(GO:0008374)
0.1 1.0 GO:0015399 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405)
0.1 1.3 GO:0033613 RNA polymerase II activating transcription factor binding(GO:0001102) activating transcription factor binding(GO:0033613)
0.1 2.2 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.6 GO:0034739 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H3-K9 specific)(GO:0032129) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.1 0.2 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.1 7.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 1.9 GO:0036459 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 0.5 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.5 GO:0017022 myosin binding(GO:0017022)
0.1 1.2 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 0.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.3 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774) amino acid kinase activity(GO:0019202)
0.1 3.1 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.2 GO:0030332 cyclin binding(GO:0030332)
0.1 0.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.5 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 5.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 0.2 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.1 0.9 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.7 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.1 0.9 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.7 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.5 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 10.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
2.3 6.9 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.7 1.7 PID AR PATHWAY Coregulation of Androgen receptor activity
1.2 2.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
1.1 3.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
1.1 4.5 PID CMYB PATHWAY C-MYB transcription factor network
1.0 3.1 PID FOXO PATHWAY FoxO family signaling
1.0 5.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.8 2.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.5 4.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.5 718.7 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.3 1.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 0.2 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 0.2 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 6.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
2.6 7.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
2.5 7.5 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
1.0 9.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.7 2.0 REACTOME TRIF MEDIATED TLR3 SIGNALING Genes involved in TRIF mediated TLR3 signaling
0.5 4.7 REACTOME MEIOSIS Genes involved in Meiosis
0.5 716.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.5 4.1 REACTOME DNA REPAIR Genes involved in DNA Repair
0.4 1.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 1.0 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.2 0.9 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.1 0.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.0 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4