Results for AFT2
Z-value: 3.67
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Transcription factors associated with AFT2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
AFT2
|
S000006123 | Iron-regulated transcriptional activator |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YOR382W Show fit | 110.34 |
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall |
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| YHR217C Show fit | 103.53 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R. |
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| YHR218W Show fit | 71.35 |
Helicase-like protein encoded within the telomeric Y' element |
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| YFL063W Show fit | 70.21 |
Dubious open reading frame, based on available experimental and comparative sequence data |
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| YFL064C Show fit | 61.71 |
Putative protein of unknown function |
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| YFL062W Show fit | 50.36 |
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins |
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| YOR383C Show fit | 38.35 |
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall |
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| YDR536W Show fit | 35.80 |
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
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| YNL336W Show fit | 34.96 |
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins |
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| YNL339C Show fit | 32.47 |
Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p |
Network of associatons between targets according to the STRING database.
First level regulatory network of AFT2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 25.0 | 200.2 | GO:0015891 | siderophore transport(GO:0015891) |
| 8.0 | 39.8 | GO:0015793 | glycerol transport(GO:0015793) |
| 1.2 | 32.2 | GO:0055072 | iron ion homeostasis(GO:0055072) |
| 10.5 | 31.5 | GO:0035948 | regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414) |
| 5.2 | 31.4 | GO:0000501 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 0.5 | 31.3 | GO:0030437 | ascospore formation(GO:0030437) cell development(GO:0048468) |
| 1.3 | 31.0 | GO:0061726 | mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726) |
| 2.2 | 28.7 | GO:0007135 | meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144) |
| 1.9 | 26.2 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 6.5 | 26.0 | GO:0006848 | pyruvate transport(GO:0006848) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 188.7 | GO:0000323 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 3.2 | 158.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.6 | 110.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.3 | 94.6 | GO:0005886 | plasma membrane(GO:0005886) |
| 1.1 | 31.9 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.5 | 27.4 | GO:0010008 | endosome membrane(GO:0010008) |
| 2.1 | 26.9 | GO:0005619 | ascospore wall(GO:0005619) |
| 0.3 | 17.5 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 2.9 | 17.4 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 2.4 | 16.9 | GO:0000112 | nucleotide-excision repair factor 3 complex(GO:0000112) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.0 | 75.2 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 1.3 | 62.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 5.5 | 49.9 | GO:0016723 | ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723) |
| 9.7 | 38.7 | GO:0015603 | siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927) |
| 7.9 | 31.4 | GO:0005537 | mannose binding(GO:0005537) |
| 2.4 | 29.0 | GO:0022838 | substrate-specific channel activity(GO:0022838) |
| 0.5 | 27.4 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 2.1 | 27.0 | GO:0015297 | antiporter activity(GO:0015297) |
| 8.2 | 24.7 | GO:0016406 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 2.4 | 23.7 | GO:0015293 | symporter activity(GO:0015293) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 718.7 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 2.6 | 10.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 2.3 | 6.9 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 1.0 | 5.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 1.1 | 4.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.5 | 4.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 1.1 | 3.4 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 1.0 | 3.1 | PID FOXO PATHWAY | FoxO family signaling |
| 0.8 | 2.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.2 | 2.4 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 716.7 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 1.0 | 9.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 2.6 | 7.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 2.5 | 7.5 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 3.1 | 6.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.5 | 4.7 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.5 | 4.1 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.7 | 2.0 | REACTOME TRIF MEDIATED TLR3 SIGNALING | Genes involved in TRIF mediated TLR3 signaling |
| 0.4 | 1.2 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.2 | 1.0 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |