Results for ARO80
Z-value: 0.76
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Transcription factors associated with ARO80
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ARO80
|
S000002829 | Zinc-finger transcriptional activator of the Zn2Cys6 family |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 4.09 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 3.39 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YDR098C Show fit | 3.08 |
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage |
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| YPR157W Show fit | 2.77 |
Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation |
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| YHR136C Show fit | 2.73 |
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
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| YER131W Show fit | 2.63 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein |
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| YMR001C-A Show fit | 2.59 |
Putative protein of unknown function |
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| YDR033W Show fit | 2.37 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
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| YGL055W Show fit | 2.35 |
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria |
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| YLR154C Show fit | 2.34 |
Ribonuclease H2 subunit, required for RNase H2 activity |
Network of associatons between targets according to the STRING database.
First level regulatory network of ARO80
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.6 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.3 | 5.3 | GO:0006407 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.1 | 4.1 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.1 | 4.0 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.6 | 3.9 | GO:0046501 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.0 | 3.7 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.9 | 3.4 | GO:0000296 | spermine transport(GO:0000296) |
| 0.3 | 3.3 | GO:0052803 | histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803) |
| 0.1 | 3.0 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 0.2 | 2.8 | GO:0019682 | pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 10.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 5.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 4.7 | GO:0005933 | cellular bud(GO:0005933) |
| 0.1 | 4.2 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.0 | 2.9 | GO:0005730 | nucleolus(GO:0005730) |
| 0.8 | 2.5 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.2 | 2.3 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 2.0 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.1 | 2.0 | GO:0015935 | small ribosomal subunit(GO:0015935) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 4.0 | GO:0016875 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.3 | 3.7 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.9 | 3.5 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.9 | 3.4 | GO:0000297 | spermine transmembrane transporter activity(GO:0000297) |
| 0.5 | 3.2 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.1 | 2.9 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.2 | 2.7 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 0.6 | 2.5 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.8 | 2.4 | GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 0.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 0.2 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 0.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 0.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.1 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 1.3 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.1 | 1.1 | REACTOME GPCR DOWNSTREAM SIGNALING | Genes involved in GPCR downstream signaling |
| 0.2 | 0.9 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 0.9 | REACTOME DEADENYLATION DEPENDENT MRNA DECAY | Genes involved in Deadenylation-dependent mRNA decay |
| 0.1 | 0.8 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.2 | 0.7 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 0.1 | 0.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 0.4 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.2 | 0.3 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |