Results for AZF1
Z-value: 2.59
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Transcription factors associated with AZF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
AZF1
|
S000005639 | Zinc-finger transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 62.25 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 53.57 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YIL053W Show fit | 28.03 |
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress |
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| YPR119W Show fit | 26.16 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YDR033W Show fit | 24.84 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
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| YDR044W Show fit | 23.10 |
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) |
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| YHR094C Show fit | 22.40 |
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting |
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| YDL055C Show fit | 20.74 |
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure |
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| YJR094W-A Show fit | 20.17 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein |
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| YMR290W-A Show fit | 19.64 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase |
Network of associatons between targets according to the STRING database.
First level regulatory network of AZF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 313.5 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 20.4 | 61.1 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 3.3 | 58.6 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.6 | 56.9 | GO:0006364 | rRNA processing(GO:0006364) |
| 6.6 | 46.3 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 6.3 | 31.5 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 4.2 | 29.3 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 9.6 | 28.8 | GO:0019401 | glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) |
| 2.7 | 27.5 | GO:0006797 | polyphosphate metabolic process(GO:0006797) |
| 0.8 | 27.5 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 232.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.8 | 149.3 | GO:0005933 | cellular bud(GO:0005933) |
| 2.2 | 135.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.6 | 63.7 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 55.7 | GO:0005634 | nucleus(GO:0005634) |
| 1.1 | 40.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.6 | 34.6 | GO:0030684 | preribosome(GO:0030684) |
| 0.8 | 30.6 | GO:0005811 | lipid particle(GO:0005811) |
| 2.0 | 28.3 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 1.5 | 26.2 | GO:0022626 | cytosolic ribosome(GO:0022626) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 346.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.2 | 75.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 2.3 | 59.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.7 | 56.6 | GO:0016791 | phosphatase activity(GO:0016791) |
| 0.3 | 56.3 | GO:0003723 | RNA binding(GO:0003723) |
| 8.4 | 50.4 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 1.3 | 41.3 | GO:0008186 | RNA-dependent ATPase activity(GO:0008186) |
| 2.0 | 28.3 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 4.7 | 28.0 | GO:0016408 | C-acyltransferase activity(GO:0016408) |
| 0.8 | 26.3 | GO:0016875 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 8.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.5 | 5.4 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 1.2 | 4.7 | PID E2F PATHWAY | E2F transcription factor network |
| 1.4 | 4.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 1.0 | 3.9 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.9 | 3.5 | PID P73PATHWAY | p73 transcription factor network |
| 1.0 | 3.1 | PID SHP2 PATHWAY | SHP2 signaling |
| 1.0 | 2.9 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.7 | 2.7 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 1.8 | 1.8 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 48.2 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 3.7 | 29.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 2.4 | 19.1 | REACTOME SIGNALING BY GPCR | Genes involved in Signaling by GPCR |
| 1.2 | 8.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.9 | 7.6 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.9 | 6.4 | REACTOME METABOLISM OF MRNA | Genes involved in Metabolism of mRNA |
| 1.5 | 5.9 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.5 | 5.5 | REACTOME MITOTIC M M G1 PHASES | Genes involved in Mitotic M-M/G1 phases |
| 2.3 | 4.6 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 1.0 | 3.9 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |