Navigation
Downloads

Results for CBF1

Z-value: 1.17

Motif logo

logo of

Transcription factors associated with CBF1

Gene Symbol Gene ID Gene Info
CBF1
S000003821 Dual function helix-loop-helix protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CBF1YJR060W-0.758.9e-06Click!

Activity profile of CBF1 motif

Sorted Z-values of CBF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YDR509W 17.39 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR508C 17.07
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YPL250W-A 13.52 Identified by fungal homology and RT-PCR
YHR136C 12.96
SPL2
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR502C 9.71
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YER124C 9.14
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YJR009C 8.58
TDH2
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YDR497C 8.54
ITR1
Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YFR055W 7.75
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YHR137W 7.62
ARO9
Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YJL158C 7.53
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YML123C 6.75
PHO84
High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YFR056C 6.58 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YMR290C 6.09
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YEL001C 6.06
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YER001W 5.84
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YMR290W-A 5.56 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YOL101C 5.03
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YKL008C 4.97
LAC1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YLR150W 4.93
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YER091C 4.71
MET6
Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YNL178W 4.60
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YJL153C 4.57
INO1
Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YBR249C 4.50
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YJL167W 4.43
ERG20
Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YJR094W-A 3.96
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YER043C 3.96
SAH1
S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YAL012W 3.91
CYS3
Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine
YCR018C 3.70
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YJR105W 3.65
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YMR217W 3.63
GUA1
GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YGR155W 3.58
CYS4
Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YJR010W 3.57
MET3
ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YKL068W-A 3.55 Putative protein of unknown function; identified by homology to Ashbya gossypii
YBL077W 3.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YJR145C 3.51
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YAL003W 3.48
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YIL118W 3.41
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YKL182W 3.40
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YHR089C 3.35
GAR1
Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YGL148W 3.28
ARO2
Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YDR510W 3.25
SMT3
Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YGL077C 3.18
HNM1
Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
YML119W 3.15 Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YER177W 3.11
BMH1
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YPL019C 3.00
VTC3
Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
YLR029C 2.99
RPL15A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YCR099C 2.96 Putative protein of unknown function
YGL055W 2.90
OLE1
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YAL038W 2.89
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YOR376W-A 2.89 Putative protein of unknown function; identified by fungal homology and RT-PCR
YDR382W 2.88
RPP2B
Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YIL127C 2.86 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YNR013C 2.85
PHO91
Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YCR004C 2.84
YCP4
Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR023W 2.82
SES1
Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YDL023C 2.80 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YNL175C 2.80
NOP13
Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA
YHR032W-A 2.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A
YPR157W 2.78 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YER026C 2.76
CHO1
Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
YDR041W 2.73
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YPR102C 2.72
RPL11A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YMR123W 2.67
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YDL022C-A 2.65 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YGR052W 2.53
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YKR074W 2.52
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YPL177C 2.50
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YBL085W 2.50
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YLR162W-A 2.47 Putative protein of unknown function identified by fungal homology comparisons and RT-PCR
YLR409C 2.45
UTP21
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YGL001C 2.44
ERG26
C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YLR301W 2.44 Protein of unknown function that interacts with Sec72p
YER055C 2.39
HIS1
ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YDR040C 2.38
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YOR327C 2.38
SNC2
Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YNR016C 2.38
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YDL022W 2.36
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YNL043C 2.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YJL188C 2.25
BUD19
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YER074W 2.25
RPS24A
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YPL231W 2.22
FAS2
Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; phosphorylated
YPR010C 2.21
RPA135
RNA polymerase I subunit A135
YHR094C 2.20
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YNL113W 2.19
RPC19
RNA polymerase subunit, common to RNA polymerases I and III
YLR249W 2.17
YEF3
Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YHR141C 2.12
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YHR010W 2.10
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YDR072C 2.08
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YML121W 2.08
GTR1
Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YOR375C 2.06
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YMR194C-A 2.06 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER146W 2.06
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YGR234W 2.05
YHB1
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YJL012C 2.03
VTC4
Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
YOR099W 2.03
KTR1
Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family
YOL136C 2.01
PFK27
6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YGR050C 1.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL128C 1.97
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YAR071W 1.97
PHO11
One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YLR065C 1.96 Putative protein of unknown function; YLR065C is not an essential gene
YGR157W 1.94
CHO2
Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YBR066C 1.88
NRG2
Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YDR531W 1.87 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YDR344C 1.83 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR060W 1.83
ERG25
C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YLR257W 1.83 Putative protein of unknown function
YAR008W 1.82
SEN34
Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
YGR200C 1.81
ELP2
Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
YOR153W 1.78
PDR5
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YKL080W 1.78
VMA5
Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YOR163W 1.76
DDP1
Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases
YJL168C 1.75
SET2
Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
YGL076C 1.75
RPL7A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YJL115W 1.75
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YKL007W 1.73
CAP1
Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
YAL053W 1.73
FLC2
Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YFR001W 1.70
LOC1
Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles
YDR267C 1.68
CIA1
Essential protein involved in assembly of cytosolic and nuclear iron-sulfur proteins
YIL074C 1.67
SER33
3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p
YLR363W-A 1.65 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YJR001W 1.65
AVT1
Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YOR025W 1.64
HST3
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YGR249W 1.59
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YIR033W 1.58
MGA2
ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YGR229C 1.58
SMI1
Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YCR012W 1.57
PGK1
3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YCR087C-A 1.56
LUG1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
YMR083W 1.56
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YDR190C 1.56
RVB1
Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
YER107W-A 1.55 Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
YFR054C 1.53 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNR054C 1.52
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YCL043C 1.52
PDI1
Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds
YPL235W 1.52
RVB2
Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
YKL127W 1.51
PGM1
Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YJL136C 1.51
RPS21B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YER052C 1.50
HOM3
Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YPL198W 1.49
RPL7B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YBL003C 1.49
HTA2
One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YGR251W 1.48 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YML075C 1.47
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YMR198W 1.45
CIK1
Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p
YDL112W 1.42
TRM3
2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
YLR101C 1.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
YHR083W 1.41
SAM35
Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
YNL256W 1.41
FOL1
Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
YOR011W 1.39
AUS1
Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YJL010C 1.39
NOP9
Essential component of pre-40S ribosomes that is required for early cleavages of 35S pre-rRNA and hence formation of 18S rRNA; binds RNA in vitro and contains multiple pumilio-like repeats
YDR050C 1.38
TPI1
Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
YER107C 1.38
GLE2
Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
YER073W 1.37
ALD5
Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YGL189C 1.34
RPS26A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein
YBR093C 1.34
PHO5
Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YBL002W 1.33
HTB2
One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YAR002W 1.33
NUP60
Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
YOR013W 1.32
IRC11
Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
YOR230W 1.30
WTM1
Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
YPR029C 1.30
APL4
Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YOR315W 1.27
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YNL130C 1.26
CPT1
Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription
YPL254W 1.24
HFI1
Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
YGR146C-A 1.24 Putative protein of unknown function
YNL160W 1.21
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YML018C 1.18 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene
YOL064C 1.18
MET22
Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway
YGR169C-A 1.17 Putative protein of unknown function
YLR325C 1.16
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YIR042C 1.16 Putative protein of unknown function; YIR042C is a non-essential gene
YCR051W 1.14 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene
YER057C 1.14
HMF1
Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
YIL106W 1.14
MOB1
Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex
YJL109C 1.13
UTP10
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YPL028W 1.13
ERG10
Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
YDR465C 1.12
RMT2
Arginine methyltransferase; ribosomal protein L12 is a substrate
YPR175W 1.12
DPB2
Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate
YJR114W 1.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C
YML088W 1.11
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YMR305C 1.11
SCW10
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YDR297W 1.10
SUR2
Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
YGR254W 1.09
ENO1
Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YGL034C 1.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR212W 1.07
STE4
G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
YMR319C 1.07
FET4
Low-affinity Fe(II) transporter of the plasma membrane
YJR113C 1.07
RSM7
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YKR013W 1.06
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YEL051W 1.06
VMA8
Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YNL030W 1.05
HHF2
One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YLR066W 1.05
SPC3
Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
YKL110C 1.05
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YAR002C-A 1.04
ERP1
Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YFL017W-A 1.04
SMX2
Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
YLR367W 1.03
RPS22B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YNR014W 1.02 Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YLR050C 1.02 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene
YOL155C 1.00
HPF1
Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YCR022C 1.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YBR265W 1.00
TSC10
3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
YMR246W 1.00
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YKR038C 1.00
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex

Network of associatons between targets according to the STRING database.

First level regulatory network of CBF1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.5 GO:0097052 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
2.6 7.7 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
2.4 9.7 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
1.9 7.8 GO:0009423 chorismate biosynthetic process(GO:0009423)
1.9 7.5 GO:0050667 transsulfuration(GO:0019346) homocysteine metabolic process(GO:0050667)
1.8 18.1 GO:0006797 polyphosphate metabolic process(GO:0006797)
1.7 5.2 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
1.6 4.9 GO:0060548 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
1.3 7.9 GO:0006491 N-glycan processing(GO:0006491)
1.3 9.0 GO:0060238 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238)
1.2 4.9 GO:0006021 inositol biosynthetic process(GO:0006021)
1.2 3.5 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
1.1 3.4 GO:0035952 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
1.1 7.7 GO:0015791 polyol transport(GO:0015791)
1.0 4.2 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
1.0 3.1 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
1.0 3.9 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.9 2.8 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.9 4.4 GO:0045338 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.9 3.4 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.8 5.0 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.8 12.0 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.7 1.5 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.7 3.6 GO:0006177 GMP biosynthetic process(GO:0006177)
0.7 3.5 GO:2000758 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.7 2.8 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.7 1.4 GO:2000197 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.7 2.0 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.7 2.7 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.7 2.0 GO:0044209 AMP salvage(GO:0044209)
0.6 7.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.6 1.9 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.6 2.3 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.5 3.2 GO:0072337 modified amino acid transport(GO:0072337)
0.5 3.4 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.5 4.8 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.5 2.9 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.5 1.8 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.4 1.7 GO:0030835 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.4 1.7 GO:0015883 FAD transport(GO:0015883)
0.4 5.1 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.4 1.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.4 1.2 GO:0052646 phosphatidylserine metabolic process(GO:0006658) alditol phosphate metabolic process(GO:0052646)
0.4 2.1 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.4 1.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.4 1.5 GO:0019255 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.4 1.5 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
0.4 1.5 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.4 5.8 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.4 3.6 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.4 1.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.4 1.1 GO:0015680 intracellular copper ion transport(GO:0015680)
0.4 1.4 GO:0046656 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.4 7.7 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.3 1.7 GO:0006110 regulation of glycolytic process(GO:0006110)
0.3 1.4 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.3 1.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 1.6 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.3 2.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.3 1.9 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.3 1.5 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.3 2.1 GO:0009636 response to toxic substance(GO:0009636)
0.3 0.6 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.3 0.8 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
0.3 1.9 GO:0032447 protein urmylation(GO:0032447)
0.3 0.8 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.3 1.1 GO:0000296 spermine transport(GO:0000296)
0.3 6.8 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.3 3.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.2 2.9 GO:0016925 protein sumoylation(GO:0016925)
0.2 0.7 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.2 2.4 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.2 1.4 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.2 4.9 GO:0006696 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.2 1.6 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.2 1.1 GO:0070868 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
0.2 0.7 GO:0009088 threonine biosynthetic process(GO:0009088)
0.2 1.1 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.2 0.8 GO:1902750 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) negative regulation of cell cycle G2/M phase transition(GO:1902750)
0.2 0.8 GO:0019358 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.2 4.6 GO:0006334 nucleosome assembly(GO:0006334)
0.2 0.2 GO:0009303 rRNA transcription(GO:0009303)
0.2 0.6 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.2 0.8 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.2 0.2 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.2 0.9 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.2 4.9 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.2 0.5 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.2 0.5 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.2 3.2 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.2 1.8 GO:0090662 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.2 2.5 GO:0006415 translational termination(GO:0006415)
0.2 3.1 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 25.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 0.8 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202)
0.2 1.0 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.2 1.1 GO:0035376 sterol import(GO:0035376)
0.2 2.9 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.2 0.8 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.2 1.4 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
0.2 0.5 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.1 0.3 GO:0046083 adenine metabolic process(GO:0046083)
0.1 0.7 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.3 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 0.9 GO:0009099 valine biosynthetic process(GO:0009099)
0.1 0.3 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 0.3 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.1 0.4 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.1 0.4 GO:0019413 ethanol catabolic process(GO:0006068) acetate biosynthetic process(GO:0019413) primary alcohol catabolic process(GO:0034310)
0.1 0.4 GO:0008334 histone mRNA metabolic process(GO:0008334) U1 snRNA 3'-end processing(GO:0034473) histone mRNA catabolic process(GO:0071044) nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
0.1 0.9 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.1 0.6 GO:0000162 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.1 0.2 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472)
0.1 1.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 1.7 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 0.3 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.7 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.1 0.3 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 1.0 GO:0070592 cell wall chitin biosynthetic process(GO:0006038) fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) cell wall polysaccharide biosynthetic process(GO:0070592) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.1 0.8 GO:0010695 regulation of spindle pole body separation(GO:0010695) positive regulation of spindle pole body separation(GO:0010696)
0.1 1.9 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.2 GO:0006544 glycine metabolic process(GO:0006544) glycine biosynthetic process(GO:0006545)
0.1 0.3 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446) positive regulation of nuclear division(GO:0051785)
0.1 1.1 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 3.0 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 2.7 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 0.3 GO:2001021 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.1 0.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 14.3 GO:0006364 rRNA processing(GO:0006364)
0.1 1.1 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.1 0.4 GO:0045597 positive regulation of cell fate commitment(GO:0010455) positive regulation of mating type switching(GO:0031496) positive regulation of cell differentiation(GO:0045597) positive regulation of reproductive process(GO:2000243)
0.1 0.4 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 1.1 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 0.6 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.1 0.4 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.2 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.1 0.4 GO:0045014 negative regulation of transcription from RNA polymerase II promoter by glucose(GO:0000433) negative regulation of transcription by glucose(GO:0045014)
0.1 0.7 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 0.2 GO:0046174 polyol catabolic process(GO:0046174)
0.1 0.3 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 0.4 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1 0.4 GO:0044070 regulation of anion transport(GO:0044070)
0.1 0.3 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.1 0.6 GO:0006012 galactose metabolic process(GO:0006012)
0.1 1.0 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.2 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.1 GO:0042843 D-xylose catabolic process(GO:0042843)
0.1 0.9 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.1 0.6 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.1 0.2 GO:0032978 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979)
0.1 0.3 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.1 1.7 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 0.4 GO:0010921 regulation of phosphatase activity(GO:0010921) regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.4 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.3 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.4 GO:0090151 establishment of protein localization to mitochondrial membrane(GO:0090151)
0.1 0.1 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.1 1.1 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 0.2 GO:0051238 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.0 0.5 GO:0006825 copper ion transport(GO:0006825)
0.0 0.2 GO:0030833 regulation of actin polymerization or depolymerization(GO:0008064) actin filament polymerization(GO:0030041) regulation of actin filament length(GO:0030832) regulation of actin filament polymerization(GO:0030833)
0.0 0.2 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 4.1 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.2 GO:0035392 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.0 0.1 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.0 0.1 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.0 0.3 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.3 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 1.2 GO:0007015 actin filament organization(GO:0007015)
0.0 0.5 GO:0031106 septin ring organization(GO:0031106)
0.0 0.6 GO:0006865 amino acid transport(GO:0006865)
0.0 1.9 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.2 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.0 0.3 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.4 GO:0007120 axial cellular bud site selection(GO:0007120)
0.0 0.2 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.1 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.4 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 0.0 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.0 0.1 GO:0007030 Golgi organization(GO:0007030)
0.0 0.4 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.4 GO:0006999 nuclear pore organization(GO:0006999)
0.0 1.1 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0048255 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0 0.1 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.8 GO:0006839 mitochondrial transport(GO:0006839)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0 0.1 GO:0036260 7-methylguanosine RNA capping(GO:0009452) regulation of telomere maintenance via telomerase(GO:0032210) RNA capping(GO:0036260) regulation of telomere maintenance via telomere lengthening(GO:1904356) regulation of DNA biosynthetic process(GO:2000278)
0.0 0.0 GO:0048211 SNARE complex assembly(GO:0035493) Golgi vesicle docking(GO:0048211)
0.0 0.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.0 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.2 GO:0000077 DNA damage checkpoint(GO:0000077)
0.0 0.0 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.1 GO:0055074 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.0 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.9 2.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.8 3.4 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.8 3.1 GO:0097255 R2TP complex(GO:0097255)
0.7 3.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.6 7.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.5 2.1 GO:0034448 EGO complex(GO:0034448)
0.5 3.0 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.5 1.8 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.4 6.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.4 2.8 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 4.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 1.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 1.4 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.4 1.1 GO:0005787 signal peptidase complex(GO:0005787)
0.3 0.7 GO:0000786 nucleosome(GO:0000786)
0.3 2.6 GO:0005688 U6 snRNP(GO:0005688)
0.3 8.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.3 25.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 1.8 GO:0030133 transport vesicle(GO:0030133)
0.3 1.8 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.3 10.8 GO:0005811 lipid particle(GO:0005811)
0.3 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 4.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.3 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.7 GO:0005884 actin filament(GO:0005884)
0.2 1.4 GO:0005871 kinesin complex(GO:0005871)
0.2 1.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 1.3 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.2 0.8 GO:0000131 incipient cellular bud site(GO:0000131)
0.2 8.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 0.8 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 2.9 GO:0005940 septin ring(GO:0005940)
0.2 0.8 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.2 0.4 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.2 3.0 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 0.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 2.2 GO:0034399 nuclear periphery(GO:0034399)
0.2 0.5 GO:0000814 ESCRT II complex(GO:0000814)
0.2 9.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.5 GO:0030669 clathrin-coated pit(GO:0005905) AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) clathrin coat of coated pit(GO:0030132) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.2 3.2 GO:0030658 transport vesicle membrane(GO:0030658)
0.2 0.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 0.5 GO:0005827 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.1 0.7 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 6.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 0.7 GO:0034044 exomer complex(GO:0034044)
0.1 0.9 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.8 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 20.8 GO:0005933 cellular bud(GO:0005933)
0.1 0.5 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.3 GO:0034967 Set3 complex(GO:0034967)
0.1 11.0 GO:0000139 Golgi membrane(GO:0000139)
0.1 0.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 19.0 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 0.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.4 GO:0030120 vesicle coat(GO:0030120)
0.1 4.5 GO:0030684 preribosome(GO:0030684)
0.1 0.5 GO:0042555 MCM complex(GO:0042555)
0.1 0.9 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 4.0 GO:0005576 extracellular region(GO:0005576)
0.1 1.1 GO:0005802 trans-Golgi network(GO:0005802)
0.1 0.3 GO:0000938 GARP complex(GO:0000938)
0.1 0.3 GO:0031518 CBF3 complex(GO:0031518)
0.1 0.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.9 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.7 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 0.1 GO:0070209 ASTRA complex(GO:0070209)
0.1 2.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 1.0 GO:0070847 core mediator complex(GO:0070847)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.4 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.8 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.7 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.4 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.5 GO:0009277 fungal-type cell wall(GO:0009277)
0.0 1.1 GO:0044445 cytosolic part(GO:0044445)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0000815 ESCRT III complex(GO:0000815)
0.0 8.0 GO:0005886 plasma membrane(GO:0005886)
0.0 0.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.0 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.2 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.7 GO:0005794 Golgi apparatus(GO:0005794)
0.0 0.5 GO:0044391 ribosomal subunit(GO:0044391)
0.0 0.2 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 16.8 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
2.8 8.5 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
2.4 7.1 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.7 8.7 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
1.7 6.8 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
1.5 4.6 GO:0016872 intramolecular lyase activity(GO:0016872)
1.5 9.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.3 3.8 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
1.2 5.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.2 6.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.2 4.7 GO:0008172 S-methyltransferase activity(GO:0008172)
1.2 3.5 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
1.1 4.6 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
1.1 6.7 GO:0016408 C-acyltransferase activity(GO:0016408)
1.1 12.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
1.0 3.1 GO:0051219 phosphoprotein binding(GO:0051219)
0.9 3.6 GO:0019206 nucleoside kinase activity(GO:0019206)
0.8 4.0 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.8 3.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.8 4.6 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.7 2.1 GO:0019003 GDP binding(GO:0019003)
0.6 2.4 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.6 1.8 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.6 6.9 GO:0005199 structural constituent of cell wall(GO:0005199)
0.6 2.8 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.6 3.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.6 2.2 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.5 2.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.5 2.0 GO:0008252 nucleotidase activity(GO:0008252)
0.5 17.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.5 1.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.5 1.4 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.5 1.8 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.4 5.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 6.1 GO:0001054 RNA polymerase I activity(GO:0001054)
0.4 1.7 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.4 0.4 GO:0019202 amino acid kinase activity(GO:0019202)
0.4 1.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.4 2.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.4 1.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 1.8 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.3 1.0 GO:0016504 peptidase activator activity(GO:0016504)
0.3 3.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.3 3.2 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.3 1.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3 3.6 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.3 1.4 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.3 1.1 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.3 1.1 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.3 1.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.3 0.8 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.3 0.8 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.2 2.5 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.2 1.0 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 0.7 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 0.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 1.4 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 1.8 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.2 1.4 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2 1.3 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.2 2.2 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.2 4.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.2 6.1 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.2 2.0 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 0.6 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.2 0.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 2.9 GO:0008170 N-methyltransferase activity(GO:0008170)
0.2 7.7 GO:0019843 rRNA binding(GO:0019843)
0.2 0.7 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 5.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 0.9 GO:0070403 NAD+ binding(GO:0070403)
0.2 2.0 GO:0030276 clathrin binding(GO:0030276)
0.2 1.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 29.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 1.9 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.2 2.0 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 2.2 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
0.1 0.9 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 0.4 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 2.4 GO:0015926 glucosidase activity(GO:0015926)
0.1 0.4 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 0.5 GO:0016531 copper chaperone activity(GO:0016531)
0.1 0.6 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.1 0.6 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.1 2.3 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 0.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.3 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 1.5 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.7 GO:0030515 snoRNA binding(GO:0030515)
0.1 0.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 3.0 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.4 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.5 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.2 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 1.7 GO:0019901 protein kinase binding(GO:0019901)
0.1 0.2 GO:0004602 glutathione peroxidase activity(GO:0004602) phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 0.5 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 1.1 GO:0050661 NADP binding(GO:0050661)
0.1 0.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.3 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.4 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.4 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 0.4 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.3 GO:0051920 thioredoxin peroxidase activity(GO:0008379) peroxiredoxin activity(GO:0051920)
0.1 0.8 GO:0051015 actin filament binding(GO:0051015)
0.1 0.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 0.2 GO:0043177 amino acid binding(GO:0016597) carboxylic acid binding(GO:0031406) organic acid binding(GO:0043177)
0.1 0.9 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
0.1 0.8 GO:0005507 copper ion binding(GO:0005507)
0.1 1.1 GO:0019207 kinase regulator activity(GO:0019207)
0.1 0.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296) single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 1.2 GO:0042277 peptide binding(GO:0042277)
0.1 0.7 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.3 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.0 0.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.4 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 2.6 GO:0003924 GTPase activity(GO:0003924)
0.0 0.4 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.5 GO:0000049 tRNA binding(GO:0000049)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.4 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.6 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 1.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.9 GO:0003779 actin binding(GO:0003779)
0.0 0.4 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.6 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.2 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.0 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.2 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.9 1.7 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.5 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 1.9 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 0.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 0.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 0.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.1 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.1 PID E2F PATHWAY E2F transcription factor network
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.8 3.2 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.7 4.6 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.6 1.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.6 1.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.3 0.3 REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR Genes involved in Downstream signaling of activated FGFR
0.3 2.6 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.3 5.0 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.2 0.7 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 0.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.1 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.4 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.2 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation