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Results for CEP3

Z-value: 0.74

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Transcription factors associated with CEP3

Gene Symbol Gene ID Gene Info
CEP3
S000004778 Essential kinetochore protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CEP3YMR168C0.174.0e-01Click!

Activity profile of CEP3 motif

Sorted Z-values of CEP3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YHR092C 2.39
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YBR054W 1.39
YRO2
Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YLL053C 1.25 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YDR278C 1.21 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAR060C 1.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL216C 1.12 Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YLL052C 1.12
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YER067C-A 1.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
YCR102W-A 1.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR082C 1.06 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL160W 1.04
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YNR001W-A 1.01 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YGR139W 1.01 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL033W 1.00
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YPR157W 0.91 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YLL055W 0.91
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YEL008W 0.90 Hypothetical protein predicted to be involved in metabolism
YOL136C 0.89
PFK27
6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YBR072W 0.88
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YCR104W 0.87
PAU3
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YHR095W 0.76 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR023W 0.73
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YBR067C 0.72
TIP1
Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YER066W 0.70 Putative protein of unknown function; YER066W is not an essential gene
YHR212W-A 0.70 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPL014W 0.66 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YAR047C 0.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR036C 0.63
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YPL025C 0.62 Hypothetical protein
YFR022W 0.61
ROG3
Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YIL166C 0.61 Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
YKL163W 0.61
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YGR138C 0.60
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YPR149W 0.60
NCE102
Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YBR222C 0.59
PCS60
Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
YMR034C 0.58 Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
YDR276C 0.56
PMP3
Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YKL217W 0.55
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YBR177C 0.55
EHT1
Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YDL037C 0.54
BSC1
Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YKR040C 0.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YGL179C 0.54
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YCR021C 0.53
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YER067W 0.53 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YBR183W 0.52
YPC1
Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YHR212C 0.52 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER130C 0.50 Hypothetical protein
YDR222W 0.49 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YNR067C 0.49
DSE4
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YPR196W 0.49 Putative maltose activator
YDR269C 0.48 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR382W 0.47
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YKL162C 0.47 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YJL142C 0.47
IRC9
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci
YGR250C 0.46 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR129C 0.46
SAC6
Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
YOL097W-A 0.46 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YPL111W 0.45
CAR1
Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YKR102W 0.45
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YDR343C 0.43
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YGR249W 0.43
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YJL222W-A 0.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL107C 0.42 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YNL327W 0.42
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YOL128C 0.42
YGK3
Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YDR541C 0.42 Putative dihydrokaempferol 4-reductase
YPL103C 0.42
FMP30
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR067C 0.42 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YGL158W 0.42
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YLL058W 0.41 Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene
YDR533C 0.41
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YOR178C 0.41
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YBR182C-A 0.40 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGR254W 0.40
ENO1
Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YLR350W 0.40
ORM2
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YDR270W 0.40
CCC2
Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases
YOL059W 0.39
GPD2
NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria
YLR251W 0.39
SYM1
Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
YHL021C 0.39
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YLR120C 0.39
YPS1
Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YGR022C 0.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YOR376W 0.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YJR155W 0.38
AAD10
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YPR145C-A 0.37 Putative protein of unknown function
YOR003W 0.37
YSP3
Putative precursor to the subtilisin-like protease III
YBR158W 0.37
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YGL256W 0.37
ADH4
Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
YDL215C 0.37
GDH2
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YFR056C 0.37 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YLR142W 0.36
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YKL216W 0.35
URA1
Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YPR156C 0.35
TPO3
Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YEL063C 0.35
CAN1
Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance
YDL238C 0.34
GUD1
Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
YDR106W 0.34
ARP10
Component of the dynactin complex, localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex
YKL039W 0.34
PTM1
Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p
YIL119C 0.34
RPI1
Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YOL161C 0.34
PAU20
Hypothetical protein
YOR120W 0.33
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YBR047W 0.33
FMP23
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL214W 0.33
HXT8
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YAL067W-A 0.33 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR442W 0.33 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL196W 0.33
DSD1
D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia; specifc for D-serine, unlike the bacterial enzyme which recognizes both D-serine and L-serine as substrates
YNR034W-A 0.32 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YGL229C 0.32
SAP4
Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
YLR342W 0.32
FKS1
Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
YGR142W 0.32
BTN2
v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YCR106W 0.31
RDS1
Zinc cluster transcription factor involved in conferring resistance to cycloheximide
YHL024W 0.31
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YBL043W 0.31
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YOL015W 0.31
IRC10
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YER001W 0.31
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YLR296W 0.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL039C 0.31
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YER150W 0.31
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YOL143C 0.30
RIB4
Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin
YDR133C 0.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YBR003W 0.30
COQ1
Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
YJL082W 0.30
IML2
Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAL066W 0.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR287C 0.29 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies
YHR001W 0.29
OSH7
Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YLR420W 0.29
URA4
Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YKL062W 0.28
MSN4
Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YJL213W 0.28 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YPR108W-A 0.28 Putative protein of unknown function; identified by fungal homology and RT-PCR
YEL009C 0.28
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YPL262W 0.27
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YLR329W 0.27
REC102
Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
YFR053C 0.27
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YER066C-A 0.27 Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
YKR103W 0.27
NFT1
Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
YGL257C 0.26
MNT2
Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
YBR027C 0.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR379C-A 0.26 Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YIL050W 0.26
PCL7
Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
YEL017W 0.26
GTT3
Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YPL054W 0.26
LEE1
Zinc-finger protein of unknown function
YDL129W 0.26 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene
YIL046W-A 0.26 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YEL007W 0.25 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YLR252W 0.25 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism
YCR023C 0.25 Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
YCR022C 0.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YKL142W 0.24
MRP8
Putative mitochondrial ribosomal protein, has similarity to E. coli ribosomal protein S2
YJR061W 0.24 Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p
YEL011W 0.24
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YHR180W-A 0.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YLL056C 0.24 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YCR009C 0.24
RVS161
Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
YPR026W 0.23
ATH1
Acid trehalase required for utilization of extracellular trehalose
YGL053W 0.23
PRM8
Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
YMR251W-A 0.23
HOR7
Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor
YMR105C 0.23
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YLR174W 0.23
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YOR029W 0.23 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YOR135C 0.23
IRC14
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci
YLR113W 0.23
HOG1
Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
YGL034C 0.23 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER103W 0.23
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YGL001C 0.23
ERG26
C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YOR377W 0.23
ATF1
Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation
YBL001C 0.22
ECM15
Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
YLR297W 0.22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR102C 0.22 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YEL020C 0.22 Hypothetical protein with low sequence identity to Pdc1p
YDR342C 0.22
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YDR344C 0.22 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL067C 0.22
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YAR053W 0.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR035W 0.22
IMP2
Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
YDR105C 0.22
TMS1
Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
YMR194C-A 0.21 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER158C 0.21 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YMR145C 0.21
NDE1
Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
YDR103W 0.21
STE5
Pheromone-response scaffold protein; binds kinases Ste11p, Ste7p, and Fus3p to form a MAPK cascade complex that interacts with the plasma membrane, via a PH (pleckstrin homology) and PM/NLS domain, and with Ste4p-Ste18p, during signaling
YPL024W 0.21
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YPR016W-A 0.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR151C 0.21
CTH1
Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis
YBR178W 0.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C
YER078W-A 0.20 Putative protein of unknown function; identified by fungal homology and RT-PCR
YLL059C 0.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR046C 0.20
ZTA1
Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
YLR402W 0.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL131W 0.20 Putative protein of unknown function
YLL024C 0.20
SSA2
ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall
YKL067W 0.20
YNK1
Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YOR268C 0.20 Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
YBR203W 0.20
COS111
Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL134C 0.20 Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YGR136W 0.20
LSB1
Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YKR098C 0.19
UBP11
Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
YMR081C 0.19
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YBL101C 0.19
ECM21
Non-essential protein of unknown function; promoter contains several Gcn4p binding elements
YJR152W 0.19
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YLR047C 0.19
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YPL185W 0.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YDR148C 0.19
KGD2
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
YGR043C 0.19
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity

Network of associatons between targets according to the STRING database.

First level regulatory network of CEP3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0000101 sulfur amino acid transport(GO:0000101)
0.3 0.9 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 0.9 GO:0000296 spermine transport(GO:0000296)
0.2 0.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 0.5 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.2 0.5 GO:0005993 trehalose catabolic process(GO:0005993)
0.2 0.7 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.2 0.5 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.2 0.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.6 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.1 0.5 GO:0019627 urea metabolic process(GO:0019627)
0.1 0.3 GO:0006000 fructose metabolic process(GO:0006000)
0.1 0.4 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.1 0.5 GO:0006848 pyruvate transport(GO:0006848)
0.1 0.7 GO:0070941 eisosome assembly(GO:0070941)
0.1 0.4 GO:0097306 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
0.1 0.7 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.1 0.3 GO:0042843 D-xylose catabolic process(GO:0042843)
0.1 1.0 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.8 GO:0015891 siderophore transport(GO:0015891)
0.1 0.1 GO:0035952 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.1 0.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.1 0.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.3 GO:0046113 nucleobase catabolic process(GO:0046113)
0.1 0.3 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.1 0.3 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.1 0.4 GO:0019388 galactose catabolic process(GO:0019388)
0.1 0.3 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.1 0.2 GO:0060988 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 0.2 GO:0042938 dipeptide transport(GO:0042938)
0.1 1.3 GO:0007129 synapsis(GO:0007129)
0.1 0.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 0.5 GO:0006573 valine metabolic process(GO:0006573)
0.1 0.3 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.4 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.4 GO:0046337 phosphatidylethanolamine metabolic process(GO:0046337)
0.1 0.1 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 0.1 GO:0046323 glucose import(GO:0046323)
0.1 0.3 GO:0034308 ethanol metabolic process(GO:0006067) primary alcohol metabolic process(GO:0034308)
0.1 0.2 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.1 0.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.3 GO:0009208 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.1 0.2 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.1 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.3 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.1 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.0 0.3 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.2 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.0 0.2 GO:0046351 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.0 0.1 GO:0072523 purine-containing compound catabolic process(GO:0072523)
0.0 0.2 GO:0015867 ATP transport(GO:0015867)
0.0 0.1 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.0 0.2 GO:0015809 arginine transport(GO:0015809)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.3 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.2 GO:0015976 carbon utilization(GO:0015976)
0.0 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.0 0.2 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.5 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.0 0.5 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0 0.2 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.3 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.2 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.1 GO:0055088 lipid homeostasis(GO:0055088)
0.0 0.1 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.0 0.1 GO:0019357 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.0 0.1 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.2 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.0 0.1 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.0 0.2 GO:0015677 copper ion import(GO:0015677)
0.0 1.2 GO:0070726 cell wall assembly(GO:0070726)
0.0 0.8 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.4 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.1 GO:0045923 positive regulation of fatty acid metabolic process(GO:0045923)
0.0 0.1 GO:0015786 pyrimidine nucleotide-sugar transport(GO:0015781) UDP-glucose transport(GO:0015786)
0.0 0.2 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0015691 cadmium ion transport(GO:0015691)
0.0 0.1 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.1 GO:0015793 glycerol transport(GO:0015793)
0.0 0.3 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.5 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.1 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.0 0.2 GO:0042407 cristae formation(GO:0042407)
0.0 0.3 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0006026 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0 0.2 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.4 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.1 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.0 0.2 GO:0060238 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238)
0.0 0.0 GO:0046160 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.0 0.1 GO:0034090 maintenance of meiotic sister chromatid cohesion(GO:0034090)
0.0 0.0 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.2 GO:0090522 vesicle tethering involved in exocytosis(GO:0090522)
0.0 0.3 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.0 0.1 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.6 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.1 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.1 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.0 0.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.2 GO:0042886 amide transport(GO:0042886)
0.0 0.2 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.0 0.1 GO:2001038 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.2 GO:0031333 negative regulation of protein complex assembly(GO:0031333)
0.0 0.5 GO:0051445 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.0 0.2 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.1 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.0 0.0 GO:0051606 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.0 0.2 GO:0048278 vesicle docking(GO:0048278)
0.0 0.1 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.0 0.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.4 GO:0022900 electron transport chain(GO:0022900)
0.0 0.3 GO:0043086 negative regulation of catalytic activity(GO:0043086)
0.0 0.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.3 GO:0009272 fungal-type cell wall biogenesis(GO:0009272)
0.0 0.0 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.0 0.1 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.1 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.0 0.2 GO:0042181 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.0 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0010526 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.0 0.5 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.1 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.0 GO:0006546 glycine catabolic process(GO:0006546)
0.0 0.1 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.1 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.0 0.0 GO:0071049 nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
0.0 1.1 GO:0006457 protein folding(GO:0006457)
0.0 0.0 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.1 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.0 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.0 GO:0043649 glutamate catabolic process(GO:0006538) dicarboxylic acid catabolic process(GO:0043649)
0.0 0.1 GO:0007009 plasma membrane organization(GO:0007009)
0.0 0.1 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.0 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.0 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.0 GO:0018206 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:0000266 mitochondrial fission(GO:0000266)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0030428 cell septum(GO:0030428)
0.2 0.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.8 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.4 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 0.5 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 1.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.2 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.1 0.3 GO:0005869 dynactin complex(GO:0005869)
0.1 0.4 GO:0032432 actin filament bundle(GO:0032432)
0.1 0.2 GO:0070211 Snt2C complex(GO:0070211)
0.1 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.2 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.0 0.4 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0000938 GARP complex(GO:0000938)
0.0 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.2 GO:0030286 dynein complex(GO:0030286)
0.0 0.1 GO:0005771 multivesicular body(GO:0005771)
0.0 0.2 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.0 0.1 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.0 0.2 GO:0034044 exomer complex(GO:0034044)
0.0 0.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.3 GO:0098797 plasma membrane protein complex(GO:0098797)
0.0 0.7 GO:0070469 respiratory chain(GO:0070469)
0.0 0.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.3 GO:0005619 ascospore wall(GO:0005619)
0.0 0.1 GO:0035649 Nrd1 complex(GO:0035649)
0.0 0.1 GO:0030897 HOPS complex(GO:0030897)
0.0 0.2 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.2 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.3 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.0 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.6 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.1 GO:0005769 early endosome(GO:0005769)
0.0 0.0 GO:0000928 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.0 0.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.0 GO:0001400 mating projection base(GO:0001400)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 2.9 GO:0022838 substrate-specific channel activity(GO:0022838)
0.2 0.9 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.2 0.6 GO:0016289 CoA hydrolase activity(GO:0016289)
0.2 0.6 GO:0016208 AMP binding(GO:0016208)
0.2 0.9 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.2 0.7 GO:0005537 mannose binding(GO:0005537)
0.2 0.9 GO:0015295 solute:proton symporter activity(GO:0015295)
0.2 0.5 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.2 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 0.8 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 0.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.4 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.1 0.5 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.1 0.6 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.3 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.1 0.4 GO:0004396 hexokinase activity(GO:0004396)
0.1 0.5 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1 0.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.4 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.1 0.3 GO:0016417 S-acyltransferase activity(GO:0016417)
0.1 1.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 0.4 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.4 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.4 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.2 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.1 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.1 0.2 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.1 0.4 GO:0031072 heat shock protein binding(GO:0031072)
0.1 0.3 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 0.5 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 0.3 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 1.1 GO:0016298 lipase activity(GO:0016298)
0.0 0.1 GO:0019203 trehalose-phosphatase activity(GO:0004805) carbohydrate phosphatase activity(GO:0019203)
0.0 0.1 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.0 0.5 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.6 GO:0017171 serine hydrolase activity(GO:0017171)
0.0 0.3 GO:0000149 SNARE binding(GO:0000149)
0.0 0.2 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.2 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.0 0.2 GO:0004075 biotin carboxylase activity(GO:0004075)
0.0 0.1 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.0 0.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.2 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.1 GO:0015186 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.3 GO:0019239 deaminase activity(GO:0019239)
0.0 0.1 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.0 0.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.2 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.3 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.1 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.0 0.6 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.0 0.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.2 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.4 GO:0003774 motor activity(GO:0003774)
0.0 0.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.3 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.2 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.1 GO:0034979 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.0 0.1 GO:0048029 monosaccharide binding(GO:0048029)
0.0 0.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.0 0.1 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295)
0.0 0.0 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.1 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 1.0 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.0 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 0.0 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.0 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.1 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.5 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.2 GO:0016896 exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.0 0.4 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.0 0.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.0 GO:0008252 nucleotidase activity(GO:0008252)
0.0 0.4 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.0 GO:0016872 intramolecular lyase activity(GO:0016872)
0.0 0.2 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 0.0 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0015293 symporter activity(GO:0015293)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 0.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.1 PID ATM PATHWAY ATM pathway
0.0 0.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 22.1 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 0.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 0.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.2 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.1 0.2 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.1 0.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.2 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 22.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein