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Results for CUP2

Z-value: 1.23

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Transcription factors associated with CUP2

Gene Symbol Gene ID Gene Info
CUP2
S000003134 Copper-binding transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CUP2YGL166W0.815.3e-07Click!

Activity profile of CUP2 motif

Sorted Z-values of CUP2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YLR307C-A 14.98 Putative protein of unknown function
YHR053C 14.53
CUP1-1
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YHR055C 14.20
CUP1-2
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YAR053W 13.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR107W 12.83
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YIL057C 11.12 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YHR054W-A 10.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2
YJL089W 10.53
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YAR060C 9.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR244W 9.24 Putative protein of unknown function
YCR005C 8.64
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YIL162W 8.32
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YFR053C 8.18
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YKL217W 8.17
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YHR212C 7.77 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL210W 7.72
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YHR096C 7.50
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YFL030W 6.99
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YPR007C 6.68
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YHR054C 6.57 Putative protein of unknown function
YJR095W 6.42
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YCR007C 6.38 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YBR117C 6.24
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YKL031W 6.11 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YHR212W-A 5.98 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YKL103C 5.89
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YKL102C 5.28 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YFL011W 5.12
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YJR150C 5.12
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YNL117W 5.09
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YNL144C 5.06 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YDR536W 5.02
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YCL054W 4.99
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YJL130C 4.81
URA2
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YPL240C 4.74
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YFL051C 4.50 Putative protein of unknown function; YFL051C is not an essential gene
YLR122C 4.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YPL092W 4.42
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YGL255W 4.41
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YMR206W 4.35 Putative protein of unknown function; YMR206W is not an essential gene
YCR021C 4.31
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YJR078W 4.28
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YOR192C 4.11
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YEL024W 4.10
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YBL043W 4.07
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YJL037W 4.01
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YPR013C 3.97 Putative zinc finger protein; YPR013C is not an essential gene
YAL062W 3.97
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YAL039C 3.95
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YOR192C-C 3.90 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YEL028W 3.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR277C 3.80
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YDR342C 3.79
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YIR039C 3.77
YPS6
Putative GPI-anchored aspartic protease
YBR201C-A 3.72 Putative protein of unknown function
YLR123C 3.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YHR139C 3.68
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YOL052C-A 3.65
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YMR103C 3.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIR027C 3.59
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YPR010C-A 3.40 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YAR050W 3.40
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YOR382W 3.39
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YNL142W 3.39
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YOR152C 3.35 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YFL052W 3.34 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YDR034C 3.34
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YKR097W 3.28
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YMR017W 3.28
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YAR035W 3.21
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YPL057C 3.17
SUR1
Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p
YCL001W-B 3.17 Putative protein of unknown function; identified by homology
YDR102C 3.12 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YMR256C 3.09
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YIL077C 3.08 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YBR296C 3.06
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YGR043C 3.05
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YML089C 3.03 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YJR154W 3.03 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOR387C 3.02 Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YHR048W 3.00
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YOL154W 2.98
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YLR307W 2.94
CDA1
Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YLR346C 2.93 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YEL059W 2.90 Dubious open reading frame unlikely to encode a functional protein
YAR047C 2.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL014W 2.86
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YBR105C 2.85
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YOR139C 2.81 Hypothetical protein
YER065C 2.76
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YDR250C 2.74 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOR120W 2.71
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YDR542W 2.70
PAU10
Hypothetical protein
YKR102W 2.69
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YEL012W 2.68
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YJL116C 2.65
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YPR196W 2.65 Putative maltose activator
YNR002C 2.64
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YPL216W 2.63 Putative protein of unknown function; YPL216W is not an essential gene
YDR216W 2.62
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YPL054W 2.62
LEE1
Zinc-finger protein of unknown function
YOR140W 2.61
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YLL053C 2.60 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YLR149C 2.58 Putative protein of unknown function; YLR149C is not an essential gene
YMR034C 2.58 Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
YMR280C 2.57
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YDR251W 2.56
PAM1
Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
YLR124W 2.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR379C-A 2.50 Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YLR311C 2.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR033W 2.48 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YPL262W 2.46
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YIL113W 2.43
SDP1
Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
YMR096W 2.41
SNZ1
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YNL143C 2.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR347C 2.40
PYK2
Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux
YDR249C 2.37 Putative protein of unknown function
YJL038C 2.36
LOH1
Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W
YCL038C 2.35
ATG22
Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
YEL070W 2.33
DSF1
Deletion suppressor of mpt5 mutation
YEL008W 2.33 Hypothetical protein predicted to be involved in metabolism
YLR125W 2.33 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YLL052C 2.32
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YLR136C 2.31
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YER150W 2.31
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YGR256W 2.29
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YEL009C 2.29
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YBR116C 2.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YBR241C 2.25 Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YKL044W 2.25 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL217W 2.24 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YDR103W 2.23
STE5
Pheromone-response scaffold protein; binds kinases Ste11p, Ste7p, and Fus3p to form a MAPK cascade complex that interacts with the plasma membrane, via a PH (pleckstrin homology) and PM/NLS domain, and with Ste4p-Ste18p, during signaling
YLR296W 2.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR077C 2.22
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YAL060W 2.21
BDH1
NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
YER033C 2.20
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YGL072C 2.16 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YGL184C 2.16
STR3
Cystathionine beta-lyase, converts cystathionine into homocysteine
YKL221W 2.16
MCH2
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YBR045C 2.15
GIP1
Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
YLR111W 2.15 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL155C 2.11
GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YPL223C 2.10
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YMR194C-B 2.07 Putative protein of unknown function
YOL081W 2.06
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YGL104C 2.04
VPS73
Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
YNL092W 2.03 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene
YGR065C 2.03
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YER014C-A 2.03
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YPR078C 2.02 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YOR214C 2.02 Putative protein of unknown function; YOR214C is not an essential gene
YML042W 2.00
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YDR259C 1.98
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YBR035C 1.97
PDX3
Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YHR217C 1.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YER121W 1.97 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YOR343C 1.95 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDL180W 1.95 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YOR090C 1.94
PTC5
Mitochondrial type 2C protein phosphatase involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
YLR295C 1.93
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YGL045W 1.92
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YDR124W 1.92 Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
YFL003C 1.90
MSH4
Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
YOR348C 1.90
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YDR042C 1.87 Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
YDR541C 1.87 Putative dihydrokaempferol 4-reductase
YOL047C 1.86 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YPL171C 1.84
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YPR001W 1.84
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YPR026W 1.84
ATH1
Acid trehalase required for utilization of extracellular trehalose
YHR130C 1.83 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR235W 1.83
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YDR476C 1.82 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YPR027C 1.82 Putative protein of unknown function
YML090W 1.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YPR023C 1.81
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YGR045C 1.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR202W 1.79 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YHR211W 1.78
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YBR006W 1.78
UGA2
Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm
YJL144W 1.76 Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YBR223C 1.74
TDP1
Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosyl bonds to generate 3'-phosphate DNA and tyrosine, involved in the repair of DNA lesions created by topoisomerase I
YHR015W 1.74
MIP6
Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YOL082W 1.74
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YOR138C 1.74
RUP1
Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain
YFR023W 1.72
PES4
Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
YBR224W 1.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
YKR009C 1.70
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YMR081C 1.70
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YDL114W 1.69 Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
YOR121C 1.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
YMR250W 1.69
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YER116C 1.69
SLX8
Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
YCR068W 1.68
ATG15
Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YDR443C 1.68
SSN2
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
YKL032C 1.68
IXR1
Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YMR135C 1.67
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YKL028W 1.67
TFA1
TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YLR438W 1.67
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YOR394W 1.66
PAU21
Hypothetical protein

Network of associatons between targets according to the STRING database.

First level regulatory network of CUP2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 29.2 GO:0046688 response to copper ion(GO:0046688)
4.4 13.3 GO:0035948 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
3.0 9.1 GO:0015755 fructose transport(GO:0015755)
2.6 7.8 GO:0006545 glycine biosynthetic process(GO:0006545)
2.2 8.9 GO:0006848 pyruvate transport(GO:0006848)
2.1 6.4 GO:0015740 C4-dicarboxylate transport(GO:0015740)
2.1 16.6 GO:0006097 glyoxylate cycle(GO:0006097)
2.1 8.2 GO:0015847 putrescine transport(GO:0015847)
1.7 5.2 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
1.7 5.2 GO:0015888 thiamine transport(GO:0015888)
1.4 4.3 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.4 4.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.4 2.7 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
1.4 4.1 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.3 8.0 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.2 10.7 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
1.2 9.3 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
1.2 3.5 GO:0006538 glutamate catabolic process(GO:0006538)
1.1 8.9 GO:0015758 glucose transport(GO:0015758)
1.0 3.1 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
1.0 3.0 GO:0032000 regulation of fatty acid beta-oxidation(GO:0031998) positive regulation of fatty acid beta-oxidation(GO:0032000) regulation of fatty acid oxidation(GO:0046320) positive regulation of fatty acid oxidation(GO:0046321)
1.0 3.0 GO:0005993 trehalose catabolic process(GO:0005993)
1.0 3.9 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.9 4.7 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.9 1.9 GO:0015804 neutral amino acid transport(GO:0015804)
0.9 2.8 GO:0042843 D-xylose catabolic process(GO:0042843)
0.9 5.4 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.9 7.2 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.9 2.7 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.9 2.6 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.9 8.7 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.9 4.3 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.8 5.9 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.8 12.6 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.8 4.1 GO:0015793 glycerol transport(GO:0015793)
0.8 6.5 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.8 5.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.8 0.8 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.8 2.3 GO:0006824 cobalt ion transport(GO:0006824)
0.7 9.7 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.7 2.9 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.7 2.9 GO:1903138 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.7 2.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.7 5.0 GO:0006829 zinc II ion transport(GO:0006829)
0.7 1.4 GO:0045117 azole transport(GO:0045117)
0.7 4.2 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.7 0.7 GO:0045923 positive regulation of fatty acid metabolic process(GO:0045923)
0.7 0.7 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.7 3.4 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.7 2.0 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.7 6.7 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.6 7.0 GO:0072348 sulfur compound transport(GO:0072348)
0.6 4.4 GO:0015891 siderophore transport(GO:0015891)
0.6 5.6 GO:0031167 rRNA methylation(GO:0031167)
0.6 2.5 GO:0000435 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.6 1.9 GO:0046058 cAMP metabolic process(GO:0046058)
0.6 2.4 GO:0019748 secondary metabolic process(GO:0019748)
0.6 2.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.6 5.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.6 1.7 GO:0036257 multivesicular body organization(GO:0036257)
0.5 3.8 GO:0042775 respiratory electron transport chain(GO:0022904) ATP synthesis coupled electron transport(GO:0042773) mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.5 2.7 GO:0006026 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.5 2.7 GO:0000023 maltose metabolic process(GO:0000023)
0.5 4.2 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.5 4.1 GO:0006591 ornithine metabolic process(GO:0006591)
0.5 2.0 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.5 2.0 GO:0051099 positive regulation of binding(GO:0051099)
0.5 1.9 GO:0019660 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.5 6.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.5 1.9 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.5 0.9 GO:0006740 NADPH regeneration(GO:0006740)
0.5 1.4 GO:0070583 spore membrane bending pathway(GO:0070583)
0.4 1.3 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.4 1.3 GO:2000909 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.4 1.2 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.4 3.6 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.4 1.6 GO:0019346 transsulfuration(GO:0019346)
0.4 1.2 GO:0010039 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.4 2.8 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.4 4.7 GO:0006772 thiamine metabolic process(GO:0006772)
0.4 1.2 GO:0006108 malate metabolic process(GO:0006108)
0.4 0.4 GO:0006119 oxidative phosphorylation(GO:0006119)
0.4 1.5 GO:0071456 cellular response to hypoxia(GO:0071456)
0.4 0.8 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.4 1.1 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.4 1.1 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.4 1.1 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.4 2.5 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.3 1.7 GO:0006113 fermentation(GO:0006113)
0.3 1.7 GO:0001881 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.3 3.0 GO:0007129 synapsis(GO:0007129)
0.3 1.0 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.3 1.9 GO:0006855 drug transmembrane transport(GO:0006855)
0.3 1.9 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.3 1.6 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.3 1.3 GO:0015893 drug transport(GO:0015893)
0.3 0.3 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.3 0.6 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.3 1.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.3 0.3 GO:0071241 cellular response to inorganic substance(GO:0071241)
0.3 0.6 GO:0006754 ATP biosynthetic process(GO:0006754)
0.3 0.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 1.1 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.3 0.3 GO:0015688 iron chelate transport(GO:0015688)
0.3 1.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.3 4.5 GO:0015918 sterol transport(GO:0015918)
0.3 1.9 GO:0000266 mitochondrial fission(GO:0000266)
0.3 7.1 GO:0098660 inorganic ion transmembrane transport(GO:0098660)
0.3 2.1 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.3 1.0 GO:0072396 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.3 1.0 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.3 0.8 GO:0000304 response to singlet oxygen(GO:0000304)
0.3 2.3 GO:0045332 phospholipid translocation(GO:0045332)
0.2 3.5 GO:0019740 nitrogen utilization(GO:0019740)
0.2 0.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 1.6 GO:0010921 regulation of phosphatase activity(GO:0010921) regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 3.6 GO:0042026 protein refolding(GO:0042026)
0.2 0.7 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.2 0.2 GO:0007032 endosome organization(GO:0007032)
0.2 8.2 GO:0009060 aerobic respiration(GO:0009060)
0.2 0.6 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.2 0.4 GO:0032006 regulation of TOR signaling(GO:0032006)
0.2 0.2 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.2 0.8 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.2 0.4 GO:0043270 positive regulation of ion transport(GO:0043270)
0.2 1.4 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.2 0.2 GO:0009593 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.2 1.3 GO:0006641 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.2 0.8 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.2 0.6 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.2 0.4 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.2 0.2 GO:0042148 strand invasion(GO:0042148)
0.2 0.6 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.2 0.6 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.2 0.7 GO:0055088 lipid homeostasis(GO:0055088)
0.2 1.3 GO:0010526 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.2 2.1 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.2 0.7 GO:0046503 glycerolipid catabolic process(GO:0046503)
0.2 0.7 GO:0051346 negative regulation of hydrolase activity(GO:0051346)
0.2 0.3 GO:0043970 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.2 0.5 GO:0019243 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 0.7 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 0.5 GO:0042744 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.2 1.0 GO:0006465 signal peptide processing(GO:0006465)
0.2 1.1 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 1.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.2 1.7 GO:0010038 response to metal ion(GO:0010038)
0.2 0.6 GO:0006067 ethanol metabolic process(GO:0006067)
0.2 0.9 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.2 1.1 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.2 1.1 GO:0018345 protein palmitoylation(GO:0018345)
0.1 5.0 GO:0070591 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.9 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.1 3.5 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 1.7 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 0.6 GO:0015677 copper ion import(GO:0015677)
0.1 0.4 GO:0034091 regulation of maintenance of sister chromatid cohesion(GO:0034091)
0.1 0.3 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.4 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.1 0.4 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.6 GO:0006595 polyamine metabolic process(GO:0006595)
0.1 0.6 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.1 0.6 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.1 0.1 GO:0031098 stress-activated protein kinase signaling cascade(GO:0031098) regulation of stress-activated MAPK cascade(GO:0032872) stress-activated MAPK cascade(GO:0051403) regulation of stress-activated protein kinase signaling cascade(GO:0070302)
0.1 1.5 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.1 0.8 GO:0006452 translational frameshifting(GO:0006452)
0.1 1.6 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 0.3 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.1 0.9 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 0.5 GO:0016241 regulation of macroautophagy(GO:0016241) negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.1 0.2 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.1 3.0 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.2 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 0.6 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.1 0.7 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.1 0.6 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.1 1.0 GO:0015802 basic amino acid transport(GO:0015802)
0.1 0.3 GO:0033499 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 0.2 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 0.5 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 0.3 GO:0006083 acetate metabolic process(GO:0006083)
0.1 1.2 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.3 GO:0006816 calcium ion transport(GO:0006816)
0.1 1.5 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 0.5 GO:0051259 protein oligomerization(GO:0051259)
0.1 0.4 GO:0006826 iron ion transport(GO:0006826)
0.1 0.3 GO:0006739 NADP metabolic process(GO:0006739)
0.1 0.8 GO:0051318 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318)
0.1 0.4 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.2 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.5 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 0.3 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 0.2 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.3 GO:0001927 exocyst assembly(GO:0001927)
0.1 0.4 GO:0031134 sister chromatid biorientation(GO:0031134)
0.1 0.7 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.1 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.1 1.9 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.1 0.8 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.1 0.2 GO:0000409 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.1 0.4 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 1.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.2 GO:0015976 carbon utilization(GO:0015976)
0.1 1.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.1 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.1 0.4 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.4 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.1 GO:0030048 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 0.1 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.8 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 0.7 GO:0051181 cofactor transport(GO:0051181)
0.1 0.1 GO:0097035 lipid translocation(GO:0034204) regulation of membrane lipid distribution(GO:0097035)
0.1 0.8 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.1 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.1 0.2 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.9 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.2 GO:0061013 regulation of mRNA catabolic process(GO:0061013)
0.1 0.2 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 0.3 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.3 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.1 0.2 GO:0043954 cellular component maintenance(GO:0043954)
0.1 0.2 GO:0097271 protein localization to bud neck(GO:0097271)
0.1 0.3 GO:0006813 potassium ion transport(GO:0006813)
0.1 1.5 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.1 GO:0019932 second-messenger-mediated signaling(GO:0019932)
0.0 0.3 GO:0043487 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.0 0.1 GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.0 0.1 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.0 0.3 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.5 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.4 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.0 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.0 0.2 GO:1902808 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.0 0.1 GO:0015786 pyrimidine nucleotide-sugar transport(GO:0015781) UDP-glucose transport(GO:0015786)
0.0 0.3 GO:0070272 proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.1 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.7 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.1 GO:0001308 progressive alteration of chromatin involved in replicative cell aging(GO:0001304) negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.0 0.0 GO:0035822 gene conversion(GO:0035822)
0.0 0.2 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.2 GO:0070550 rDNA condensation(GO:0070550)
0.0 0.1 GO:0042407 cristae formation(GO:0042407)
0.0 0.1 GO:0090399 replicative senescence(GO:0090399)
0.0 0.4 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.0 0.5 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.1 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.0 0.1 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.0 0.1 GO:0019400 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.0 0.1 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.1 GO:0045337 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.0 0.1 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.0 0.2 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.0 0.2 GO:0046173 polyol biosynthetic process(GO:0046173)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.0 GO:0051098 regulation of binding(GO:0051098)
0.0 0.3 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.0 GO:0070726 cell wall assembly(GO:0070726)
0.0 1.8 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.1 GO:0045033 peroxisome inheritance(GO:0045033)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.0 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.0 0.1 GO:0034965 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.0 0.0 GO:0032978 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.0 0.2 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.0 GO:2001040 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.1 GO:0070941 eisosome assembly(GO:0070941)
0.0 0.0 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.0 0.0 GO:0043200 response to amino acid(GO:0043200)
0.0 0.0 GO:0009410 response to xenobiotic stimulus(GO:0009410)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0031166 integral component of vacuolar membrane(GO:0031166)
1.1 8.0 GO:0034657 GID complex(GO:0034657)
1.0 8.7 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.7 8.3 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.7 3.9 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.7 5.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) cytochrome complex(GO:0070069)
0.6 1.8 GO:0032585 multivesicular body membrane(GO:0032585)
0.6 1.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.6 2.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.6 1.7 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.6 5.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.6 1.7 GO:0001400 mating projection base(GO:0001400)
0.5 2.7 GO:0098803 mitochondrial respiratory chain(GO:0005746) respiratory chain complex(GO:0098803)
0.5 6.9 GO:0005619 ascospore wall(GO:0005619)
0.5 1.4 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.5 3.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 1.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.4 2.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.4 1.9 GO:0032221 Rpd3S complex(GO:0032221)
0.4 1.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 1.8 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.4 1.1 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.3 2.3 GO:0034967 Set3 complex(GO:0034967)
0.3 0.9 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.3 16.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 0.9 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.3 0.6 GO:0030061 mitochondrial crista(GO:0030061)
0.3 2.6 GO:0000795 synaptonemal complex(GO:0000795)
0.3 0.8 GO:0005787 signal peptidase complex(GO:0005787)
0.3 1.1 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.3 1.1 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.3 0.5 GO:0032126 eisosome(GO:0032126)
0.3 1.3 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.3 12.4 GO:0031225 anchored component of membrane(GO:0031225)
0.3 1.3 GO:0070772 PAS complex(GO:0070772)
0.2 1.7 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.2 4.0 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.2 0.9 GO:0070469 respiratory chain(GO:0070469)
0.2 4.5 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.2 1.2 GO:0031932 TORC2 complex(GO:0031932)
0.2 2.1 GO:0005769 early endosome(GO:0005769)
0.2 8.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 0.4 GO:0032389 MutLalpha complex(GO:0032389)
0.2 1.1 GO:0033263 CORVET complex(GO:0033263)
0.2 2.1 GO:0070822 Sin3-type complex(GO:0070822)
0.2 0.5 GO:0032177 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.2 3.9 GO:0016592 mediator complex(GO:0016592)
0.2 0.5 GO:0030870 Mre11 complex(GO:0030870)
0.2 2.3 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 1.4 GO:0030677 ribonuclease P complex(GO:0030677)
0.1 0.9 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 2.2 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.5 GO:0000817 COMA complex(GO:0000817)
0.1 1.0 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.3 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 13.0 GO:0000322 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 0.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.5 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 2.6 GO:0005576 extracellular region(GO:0005576)
0.1 0.5 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 11.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.3 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013)
0.1 2.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.7 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.7 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.1 0.3 GO:0034099 luminal surveillance complex(GO:0034099)
0.1 3.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.3 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 1.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.2 GO:0033551 monopolin complex(GO:0033551)
0.1 0.3 GO:0030666 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.3 GO:0071819 DUBm complex(GO:0071819)
0.1 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.0 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.3 GO:0000145 exocyst(GO:0000145)
0.1 2.8 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.1 0.2 GO:0032116 SMC loading complex(GO:0032116)
0.1 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 17.5 GO:0005886 plasma membrane(GO:0005886)
0.1 0.2 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.1 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 0.2 GO:0030869 RENT complex(GO:0030869)
0.1 0.2 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.2 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 1.2 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.2 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0005618 cell wall(GO:0005618) external encapsulating structure(GO:0030312)
0.0 0.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.3 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.4 GO:0098798 mitochondrial protein complex(GO:0098798)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0097346 INO80-type complex(GO:0097346)
0.0 0.1 GO:0000796 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 28.8 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
4.1 20.5 GO:0015295 solute:proton symporter activity(GO:0015295)
3.9 11.6 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
2.8 8.3 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
2.4 9.6 GO:0004396 hexokinase activity(GO:0004396)
2.2 8.9 GO:0005537 mannose binding(GO:0005537)
1.7 5.2 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
1.7 6.7 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
1.6 4.8 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
1.4 8.4 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
1.2 4.9 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
1.2 5.9 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
1.0 2.0 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.0 3.0 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.9 2.8 GO:0016208 AMP binding(GO:0016208)
0.9 3.7 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.9 7.4 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.9 12.0 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.8 2.5 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.8 2.5 GO:0005536 glucose binding(GO:0005536)
0.8 6.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.8 2.4 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.7 3.0 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091) TFIID-class transcription factor binding(GO:0001094)
0.7 5.9 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.7 4.4 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.7 5.7 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.7 2.8 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.7 1.4 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.7 6.3 GO:0015293 symporter activity(GO:0015293)
0.7 2.7 GO:0015386 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.6 6.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6 5.9 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.6 5.9 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.6 1.7 GO:0048038 quinone binding(GO:0048038)
0.5 2.2 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.5 1.6 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 2.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.5 2.7 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.5 2.0 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.5 4.9 GO:0010181 FMN binding(GO:0010181)
0.5 1.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.5 2.3 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.4 5.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.4 0.8 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.4 1.2 GO:0004629 phospholipase C activity(GO:0004629)
0.4 7.6 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 1.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.4 0.8 GO:0045118 azole transporter activity(GO:0045118)
0.4 2.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 1.2 GO:0016289 CoA hydrolase activity(GO:0016289)
0.4 3.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.4 3.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.4 1.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.4 1.8 GO:0008198 ferrous iron binding(GO:0008198)
0.3 2.8 GO:0031072 heat shock protein binding(GO:0031072)
0.3 16.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.3 1.0 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.3 3.0 GO:0015297 antiporter activity(GO:0015297)
0.3 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 1.0 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.3 1.0 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.3 2.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 7.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.3 2.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.3 0.3 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.3 4.5 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.3 3.0 GO:0035064 methylated histone binding(GO:0035064)
0.3 0.9 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.3 4.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.3 0.9 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.3 1.7 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.3 1.4 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.3 0.3 GO:0005261 cation channel activity(GO:0005261)
0.3 3.6 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.3 1.3 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.3 1.6 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 1.3 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.3 0.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 1.0 GO:0004180 carboxypeptidase activity(GO:0004180)
0.2 7.6 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.2 2.6 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 0.7 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.2 0.9 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.2 0.9 GO:0016417 S-acyltransferase activity(GO:0016417)
0.2 1.7 GO:0051920 peroxiredoxin activity(GO:0051920)
0.2 0.8 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 1.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 0.2 GO:0019903 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.2 0.6 GO:0000150 recombinase activity(GO:0000150)
0.2 1.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 0.8 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 0.8 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.2 1.7 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 0.4 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.2 0.7 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.2 1.6 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 0.7 GO:0019789 SUMO transferase activity(GO:0019789)
0.2 0.2 GO:0016530 metallochaperone activity(GO:0016530)
0.2 1.1 GO:0005507 copper ion binding(GO:0005507)
0.2 1.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 0.5 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.1 0.6 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 1.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.7 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.1 0.4 GO:0016872 intramolecular lyase activity(GO:0016872)
0.1 0.6 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.7 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.5 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.1 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 1.3 GO:0004872 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.1 0.4 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.1 0.8 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 0.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.1 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.1 0.3 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.1 1.2 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 0.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.6 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 0.8 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 0.3 GO:0004458 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.1 0.4 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.5 GO:0017022 myosin binding(GO:0017022)
0.1 1.4 GO:0017171 serine hydrolase activity(GO:0017171)
0.1 0.3 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 0.2 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.1 1.0 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.2 GO:0016722 oxidoreductase activity, oxidizing metal ions(GO:0016722)
0.1 1.4 GO:0005509 calcium ion binding(GO:0005509)
0.1 0.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 0.1 GO:0019842 vitamin binding(GO:0019842)
0.1 0.7 GO:0032947 protein complex scaffold(GO:0032947)
0.1 0.6 GO:0000149 SNARE binding(GO:0000149)
0.1 0.1 GO:0019213 deacetylase activity(GO:0019213)
0.1 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.2 GO:0032183 SUMO binding(GO:0032183)
0.1 1.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.2 GO:0030332 cyclin binding(GO:0030332)
0.1 1.3 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 0.2 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.1 0.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.2 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.2 GO:0016783 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.0 0.6 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0015291 secondary active transmembrane transporter activity(GO:0015291)
0.0 1.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.5 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.4 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.3 GO:0022838 substrate-specific channel activity(GO:0022838)
0.0 0.3 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.1 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.0 0.3 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128)
0.0 0.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.2 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.0 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 1.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.3 GO:0050661 NADP binding(GO:0050661)
0.0 0.5 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.0 0.2 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.1 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.0 GO:0001026 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.2 3.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.5 1.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.4 0.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.3 0.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 0.9 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.2 0.7 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.2 0.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.2 0.8 PID CMYB PATHWAY C-MYB transcription factor network
0.2 235.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 0.2 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 0.5 PID PLK1 PATHWAY PLK1 signaling events
0.1 0.3 PID P73PATHWAY p73 transcription factor network
0.1 0.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.1 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.1 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.1 PID AURORA B PATHWAY Aurora B signaling
0.0 0.0 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.5 2.1 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.4 2.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3 1.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 1.4 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.3 2.0 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 232.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.4 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 0.2 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.1 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.1 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 0.2 REACTOME ACTIVATED TLR4 SIGNALLING Genes involved in Activated TLR4 signalling
0.1 0.1 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.1 0.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.0 0.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.1 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.1 REACTOME INNATE IMMUNE SYSTEM Genes involved in Innate Immune System
0.0 0.0 REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT Genes involved in SLC-mediated transmembrane transport
0.0 0.0 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling