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Results for FKH1

Z-value: 1.18

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Transcription factors associated with FKH1

Gene Symbol Gene ID Gene Info
FKH1
S000001393 Forkhead family transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FKH1YIL131C0.831.8e-07Click!

Activity profile of FKH1 motif

Sorted Z-values of FKH1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YOR315W 29.72
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YGR108W 28.34
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YPR119W 25.72
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YER124C 14.53
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YDR033W 13.31
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YOR314W 12.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR313C 11.91
SPS4
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YIR021W 11.69
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YKL096W-A 11.68
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YJR094W-A 11.33
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YDL055C 9.65
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YFR055W 9.51
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YLR042C 9.29 Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YBR092C 8.85
PHO3
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YOR051C 8.68 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YFR056C 8.60 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YOL127W 8.52
RPL25
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YGL028C 8.16
SCW11
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YER070W 8.16
RNR1
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YLR257W 7.84 Putative protein of unknown function
YGL102C 7.64 Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YDR345C 7.64
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YBR158W 7.63
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YGL021W 7.13
ALK1
Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins
YJL011C 7.07
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YMR199W 6.32
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YOR008C-A 6.32 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YGL039W 6.29 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YAL038W 6.27
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YPR157W 6.19 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YFR032C-A 6.07
RPL29
Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate
YGR106C 5.98
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YPL250W-A 5.97 Identified by fungal homology and RT-PCR
YJR145C 5.92
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YDR418W 5.81
RPL12B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YLR333C 5.72
RPS25B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YMR177W 5.61
MMT1
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YLR167W 5.55
RPS31
Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
YER043C 5.46
SAH1
S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YHR094C 5.38
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YGL101W 5.37 Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p
YDL075W 5.18
RPL31A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YGR107W 5.15 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR040W 5.12
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YHR143W 5.03
DSE2
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YIL009W 5.02
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YOR369C 4.99
RPS12
Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YLR372W 4.95
SUR4
Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YDL228C 4.83 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1
YMR032W 4.70
HOF1
Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YHL015W 4.68
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YIL131C 4.61
FKH1
Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching
YCR099C 4.60 Putative protein of unknown function
YMR003W 4.59
AIM34
Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YDR044W 4.56
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YER011W 4.50
TIR1
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YGR195W 4.46
SKI6
3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YDR279W 4.46
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YDR133C 4.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YOL124C 4.38
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YBR029C 4.36
CDS1
Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
YKR092C 4.35
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YBR249C 4.34
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YDR098C 4.33
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YDR146C 4.27
SWI5
Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YMR144W 4.20 Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YPL141C 4.19 Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YLR367W 4.17
RPS22B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YKL128C 4.15
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YLR083C 4.01
EMP70
Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions
YBR009C 4.00
HHF1
One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YDL211C 3.97 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YAL003W 3.95
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YMR106C 3.95
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YIL009C-A 3.90
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YJL136C 3.88
RPS21B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YGL040C 3.77
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YDL084W 3.76
SUB2
Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56
YJL157C 3.76
FAR1
Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate
YJL190C 3.74
RPS22A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YDR224C 3.67
HTB1
One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YNR001W-A 3.67 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YBL092W 3.66
RPL32
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YLR300W 3.65
EXG1
Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YMR303C 3.58
ADH2
Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
YBL063W 3.56
KIP1
Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YGL123C-A 3.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YGL123W 3.52
RPS2
Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YNL066W 3.48
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YER001W 3.48
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YGL209W 3.47
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YOR312C 3.44
RPL20B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
YML052W 3.42
SUR7
Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YIL118W 3.37
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YLR411W 3.34
CTR3
High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YMR290C 3.32
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YNL043C 3.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YMR290W-A 3.25 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YNR009W 3.24
NRM1
Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
YGR251W 3.19 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YOL002C 3.19
IZH2
Plasma membrane protein involved in zinc metabolism and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
YEL040W 3.19
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YJL158C 3.13
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YDR225W 3.13
HTA1
One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YMR123W 3.10
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YDL101C 3.10
DUN1
Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
YBR011C 3.10
IPP1
Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YBR030W 3.09 Putative protein of unknown function; predicted protein contains a SET domain (S-adenosyl-L-methionine-binding fold)
YPL253C 3.09
VIK1
Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p
YGL009C 3.08
LEU1
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YML088W 3.07
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YHR108W 3.06
GGA2
Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
YLR455W 3.05 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YOL123W 3.03
HRP1
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YKL209C 3.01
STE6
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YPL051W 2.92
ARL3
GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
YGR138C 2.91
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YPL075W 2.89
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YOR222W 2.89
ODC2
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YCR043C 2.86 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
YDL003W 2.86
MCD1
Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase
YPR033C 2.86
HTS1
Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence
YLR301W 2.84 Protein of unknown function that interacts with Sec72p
YOR309C 2.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
YKL180W 2.82
RPL17A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YGL029W 2.80
CGR1
Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
YER073W 2.78
ALD5
Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YML026C 2.78
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YLR154C 2.78
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YGR179C 2.77
OKP1
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YGL103W 2.74
RPL28
Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
YBL003C 2.74
HTA2
One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YJR009C 2.73
TDH2
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YNL035C 2.73 Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
YHR181W 2.73
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YLR286C 2.71
CTS1
Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YLR325C 2.71
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YCL063W 2.71
VAC17
Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YEL001C 2.70
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YHR172W 2.70
SPC97
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YEL053W-A 2.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YMR215W 2.68
GAS3
Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YCL050C 2.65
APA1
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p
YNR072W 2.65
HXT17
Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YPL227C 2.64
ALG5
UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
YDR417C 2.63 Hypothetical protein
YGL001C 2.61
ERG26
C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YKL122C 2.59
SRP21
Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YBR244W 2.56
GPX2
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YLR268W 2.54
SEC22
R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
YLR192C 2.54
HCR1
Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA
YBR010W 2.54
HHT1
One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YPL014W 2.53 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YGL201C 2.52
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YOL031C 2.51
SIL1
Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YOL041C 2.51
NOP12
Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe
YHR064C 2.49
SSZ1
Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
YKL165C 2.48
MCD4
Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YOL101C 2.48
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YMR006C 2.47
PLB2
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YMR119W 2.47
ASI1
Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YDR278C 2.46 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL327W 2.46
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YGL179C 2.46
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YKL127W 2.44
PGM1
Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YPL197C 2.44 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
YGR140W 2.43
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YNL058C 2.43 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene
YDR341C 2.42 Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR094C 2.42
RPL40B
Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YNR054C 2.42
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YAL033W 2.41
POP5
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YGL158W 2.41
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YGR280C 2.37
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YIL169C 2.37 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YLR060W 2.37
FRS1
Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; sequence is evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase (Msf1p), but substrate binding is similar
YML071C 2.36
COG8
Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YDR451C 2.36
YHP1
One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval
YDR326C 2.35
YSP2
Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification
YHR107C 2.34
CDC12
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YJR032W 2.34
CPR7
Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YDR344C 2.34 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR183C 2.34
TOS4
Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YBL009W 2.32
ALK2
Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins
YOR009W 2.32
TIR4
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock
YER031C 2.31
YPT31
GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YFL022C 2.31
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YGR118W 2.30
RPS23A
Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YJR076C 2.30
CDC11
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YNL044W 2.30
YIP3
Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
YER048C 2.28
CAJ1
Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YER137C 2.28 Putative protein of unknown function
YLR185W 2.28
RPL37A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YLR190W 2.27
MMR1
Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
YFR054C 2.26 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR210W 2.23
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YJL193W 2.23 Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
YJL145W 2.23
SFH5
Putative phosphatidylinositol transfer protein (PITP), exhibits phosphatidylinositol- but not phosphatidylcholine-transfer activity, localized to cytosol and microsomes, similar to Sec14p; may be PITP regulator rather than actual PITP
YDR147W 2.22
EKI1
Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway
YLR084C 2.22
RAX2
N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p

Network of associatons between targets according to the STRING database.

First level regulatory network of FKH1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.9 55.1 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
3.4 10.3 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
3.2 9.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
3.1 34.1 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
2.2 10.8 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
1.8 5.3 GO:0000092 mitotic anaphase B(GO:0000092)
1.6 4.7 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
1.5 6.0 GO:0000296 spermine transport(GO:0000296)
1.5 11.8 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
1.3 4.0 GO:0035953 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
1.3 5.3 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
1.3 5.3 GO:0030497 fatty acid elongation(GO:0030497)
1.3 5.2 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
1.3 3.8 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
1.2 8.7 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
1.2 6.0 GO:0051046 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
1.2 4.7 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
1.1 3.4 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
1.1 4.5 GO:0009423 chorismate biosynthetic process(GO:0009423)
1.1 4.5 GO:0007535 donor selection(GO:0007535)
1.1 4.5 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
1.1 4.5 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
1.1 4.4 GO:0045896 regulation of transcription during mitosis(GO:0045896)
1.1 1.1 GO:0007119 budding cell isotropic bud growth(GO:0007119)
1.1 10.8 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
1.0 5.1 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
1.0 6.9 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
1.0 3.9 GO:0006657 CDP-choline pathway(GO:0006657)
0.9 13.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.9 1.9 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.9 3.6 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.9 0.9 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.9 18.1 GO:0006450 regulation of translational fidelity(GO:0006450)
0.9 8.0 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.9 4.4 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.8 2.5 GO:0006531 aspartate metabolic process(GO:0006531)
0.8 3.3 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.8 2.4 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.8 4.9 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.8 2.4 GO:0019413 acetate biosynthetic process(GO:0019413)
0.8 108.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.8 1.6 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
0.8 3.9 GO:0000433 negative regulation of transcription from RNA polymerase II promoter by glucose(GO:0000433) negative regulation of transcription by glucose(GO:0045014)
0.8 19.7 GO:0006334 nucleosome assembly(GO:0006334)
0.8 0.8 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.7 2.2 GO:0006528 asparagine metabolic process(GO:0006528)
0.7 1.5 GO:0036213 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.7 7.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.7 3.4 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.7 2.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.7 2.0 GO:0006571 tyrosine biosynthetic process(GO:0006571)
0.6 0.6 GO:0097271 protein localization to bud neck(GO:0097271)
0.6 8.8 GO:0000921 septin ring assembly(GO:0000921)
0.6 8.1 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.6 5.6 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.6 0.6 GO:0032368 regulation of lipid transport(GO:0032368)
0.6 14.1 GO:0006885 regulation of pH(GO:0006885)
0.6 9.8 GO:0032508 DNA duplex unwinding(GO:0032508)
0.6 0.6 GO:0010182 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.6 2.8 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.6 3.3 GO:0006491 N-glycan processing(GO:0006491)
0.6 2.2 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.6 1.7 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.6 31.9 GO:0007124 pseudohyphal growth(GO:0007124)
0.5 1.6 GO:0006567 threonine catabolic process(GO:0006567)
0.5 2.2 GO:0015867 ATP transport(GO:0015867)
0.5 9.7 GO:0030488 tRNA methylation(GO:0030488)
0.5 2.1 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.5 2.1 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.5 0.5 GO:0019348 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.5 4.7 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
0.5 3.1 GO:0046037 GMP metabolic process(GO:0046037)
0.5 1.5 GO:0030031 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
0.5 5.1 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.5 1.0 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.5 3.0 GO:0048478 replication fork protection(GO:0048478)
0.5 1.0 GO:0006110 regulation of glycolytic process(GO:0006110)
0.5 2.0 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.5 2.5 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.5 2.0 GO:1902750 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) negative regulation of cell cycle G2/M phase transition(GO:1902750)
0.5 2.5 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.5 2.0 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.5 3.4 GO:0070058 tRNA gene clustering(GO:0070058)
0.5 0.5 GO:0048313 Golgi inheritance(GO:0048313)
0.5 2.3 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.5 2.8 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.5 0.9 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.4 0.9 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.4 3.1 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.4 0.4 GO:0070827 chromatin maintenance(GO:0070827)
0.4 2.1 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.4 1.3 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.4 10.4 GO:0008219 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.4 1.2 GO:1901970 positive regulation of mitotic nuclear division(GO:0045840) positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101) positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.4 1.2 GO:0042990 regulation of transcription factor import into nucleus(GO:0042990) negative regulation of transcription factor import into nucleus(GO:0042992)
0.4 2.8 GO:0009098 leucine biosynthetic process(GO:0009098)
0.4 7.6 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.4 3.6 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.4 4.4 GO:0010970 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) cytoskeleton-dependent intracellular transport(GO:0030705) organelle transport along microtubule(GO:0072384)
0.4 0.8 GO:0019358 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.4 1.9 GO:0006021 inositol biosynthetic process(GO:0006021)
0.4 0.7 GO:0000076 DNA replication checkpoint(GO:0000076)
0.4 4.0 GO:0009636 response to toxic substance(GO:0009636)
0.4 2.9 GO:0007120 axial cellular bud site selection(GO:0007120)
0.4 1.1 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.4 1.8 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.4 2.1 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.4 3.5 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.4 1.4 GO:0043007 maintenance of rDNA(GO:0043007)
0.3 2.1 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.3 4.2 GO:0071047 nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.3 5.7 GO:0006730 one-carbon metabolic process(GO:0006730)
0.3 0.7 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.3 3.3 GO:0007052 mitotic spindle organization(GO:0007052)
0.3 1.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.3 2.0 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) isoleucine biosynthetic process(GO:0009097)
0.3 2.0 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.3 3.6 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.3 2.3 GO:0032042 mitochondrial DNA metabolic process(GO:0032042)
0.3 1.9 GO:0006448 regulation of translational elongation(GO:0006448)
0.3 1.6 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.3 3.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.3 5.0 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.3 0.9 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.3 1.5 GO:0035376 sterol import(GO:0035376)
0.3 0.9 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.3 4.6 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.3 2.7 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.3 1.5 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.3 3.8 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.3 1.2 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.3 1.2 GO:0051647 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.3 2.5 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.3 3.3 GO:0015833 peptide transport(GO:0015833)
0.3 2.5 GO:0009395 phospholipid catabolic process(GO:0009395)
0.3 1.6 GO:0016233 telomere capping(GO:0016233)
0.3 3.8 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.3 0.5 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.3 6.3 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.3 1.6 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.3 2.3 GO:0000011 vacuole inheritance(GO:0000011)
0.3 7.2 GO:0016129 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.3 4.4 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.3 2.5 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.2 4.9 GO:0006378 mRNA polyadenylation(GO:0006378)
0.2 0.5 GO:0070813 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.2 0.7 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.2 0.7 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.2 2.4 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 0.7 GO:0001173 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111) DNA-templated transcriptional start site selection(GO:0001173) transcriptional start site selection at RNA polymerase II promoter(GO:0001174)
0.2 3.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.2 0.7 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.2 1.2 GO:0045116 protein neddylation(GO:0045116)
0.2 0.7 GO:0006344 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.2 2.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.2 1.8 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.2 1.1 GO:0042559 folic acid-containing compound metabolic process(GO:0006760) folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound metabolic process(GO:0042558) pteridine-containing compound biosynthetic process(GO:0042559)
0.2 3.1 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.2 0.4 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.2 1.5 GO:0006901 vesicle coating(GO:0006901)
0.2 0.4 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.2 2.8 GO:0006999 nuclear pore organization(GO:0006999)
0.2 0.6 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.2 0.6 GO:0023021 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.2 0.8 GO:0070189 kynurenine metabolic process(GO:0070189)
0.2 6.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.2 0.8 GO:0051016 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.2 0.6 GO:0000101 sulfur amino acid transport(GO:0000101)
0.2 1.0 GO:0018344 protein geranylgeranylation(GO:0018344)
0.2 0.2 GO:0048211 Golgi vesicle docking(GO:0048211)
0.2 0.4 GO:0015680 intracellular copper ion transport(GO:0015680)
0.2 2.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.2 0.2 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.2 1.0 GO:0007021 tubulin complex assembly(GO:0007021)
0.2 0.9 GO:0030011 maintenance of cell polarity(GO:0030011)
0.2 0.5 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.2 0.9 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 3.9 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2 3.5 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.2 0.5 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.2 0.8 GO:0006563 L-serine metabolic process(GO:0006563)
0.2 1.3 GO:0009435 NAD biosynthetic process(GO:0009435)
0.2 1.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 0.5 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.2 0.9 GO:0016559 peroxisome fission(GO:0016559)
0.2 0.5 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.2 1.4 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.2 0.8 GO:0042435 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.1 1.0 GO:0006469 negative regulation of protein kinase activity(GO:0006469) negative regulation of kinase activity(GO:0033673)
0.1 0.6 GO:0007157 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.1 0.1 GO:0070868 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
0.1 1.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 1.4 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 0.4 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.7 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 4.2 GO:0000910 cytokinesis(GO:0000910)
0.1 9.7 GO:0006913 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.1 0.1 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 0.4 GO:0030837 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.1 0.7 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.1 1.2 GO:0019954 cell budding(GO:0007114) asexual reproduction(GO:0019954)
0.1 0.3 GO:0007051 spindle organization(GO:0007051)
0.1 1.2 GO:0031070 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.1 2.9 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.6 GO:0060304 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.1 1.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 6.8 GO:0016311 dephosphorylation(GO:0016311)
0.1 0.2 GO:0046083 adenine metabolic process(GO:0046083)
0.1 4.8 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 2.0 GO:0048311 mitochondrion inheritance(GO:0000001) mitochondrion distribution(GO:0048311)
0.1 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.7 GO:0007323 peptide pheromone maturation(GO:0007323)
0.1 0.6 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 1.6 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 0.4 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.1 2.0 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.6 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.2 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.1 0.5 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.2 GO:0042256 mature ribosome assembly(GO:0042256)
0.1 2.7 GO:0006413 translational initiation(GO:0006413)
0.1 0.2 GO:0000348 mRNA branch site recognition(GO:0000348)
0.1 0.5 GO:0009306 protein secretion(GO:0009306)
0.1 0.8 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.1 1.5 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 1.9 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 0.4 GO:0036260 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260)
0.1 0.4 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.6 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 1.2 GO:0045047 protein targeting to ER(GO:0045047)
0.1 0.2 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.1 1.3 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.1 0.9 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 1.5 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.1 0.5 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 1.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.1 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.1 0.4 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.1 0.2 GO:0000032 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.1 0.2 GO:2000756 regulation of histone acetylation(GO:0035065) positive regulation of histone acetylation(GO:0035066) regulation of protein acetylation(GO:1901983) positive regulation of protein acetylation(GO:1901985) regulation of peptidyl-lysine acetylation(GO:2000756) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.1 0.3 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.1 0.3 GO:0051668 localization within membrane(GO:0051668)
0.1 0.4 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.1 0.4 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.8 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.1 0.9 GO:0007015 actin filament organization(GO:0007015)
0.1 0.9 GO:0016197 endosomal transport(GO:0016197)
0.1 0.4 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.1 0.2 GO:0071267 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.1 0.4 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.4 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.2 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.0 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.4 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.9 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.2 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.0 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.5 GO:0042255 ribosome assembly(GO:0042255)
0.0 0.2 GO:0052803 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.0 0.8 GO:0006400 tRNA modification(GO:0006400)
0.0 0.1 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.0 0.2 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.0 0.1 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.2 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.2 GO:0000320 re-entry into mitotic cell cycle(GO:0000320) re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 0.2 GO:0090151 establishment of protein localization to mitochondrial membrane(GO:0090151)
0.0 0.0 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.1 GO:0034249 negative regulation of cellular amide metabolic process(GO:0034249)
0.0 0.1 GO:0015883 FAD transport(GO:0015883)
0.0 0.1 GO:0048193 Golgi vesicle transport(GO:0048193)
0.0 0.2 GO:0008033 tRNA processing(GO:0008033)
0.0 0.1 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.0 GO:0009847 spore germination(GO:0009847)
0.0 0.1 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.1 GO:0008655 pyrimidine-containing compound salvage(GO:0008655)
0.0 0.0 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.0 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.0 0.0 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.0 8.1 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
2.0 6.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.7 15.4 GO:0000144 cellular bud neck septin ring(GO:0000144)
1.7 10.1 GO:0005871 kinesin complex(GO:0005871)
1.5 18.2 GO:0000788 nuclear nucleosome(GO:0000788)
1.5 25.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.3 5.1 GO:0042597 periplasmic space(GO:0042597)
1.2 3.7 GO:0030428 cell septum(GO:0030428)
1.1 5.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.0 3.1 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
1.0 60.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.0 82.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.9 5.7 GO:0005880 nuclear microtubule(GO:0005880)
0.9 5.6 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.9 3.5 GO:0030907 MBF transcription complex(GO:0030907)
0.8 2.5 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.8 5.8 GO:0005884 actin filament(GO:0005884)
0.8 4.9 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.8 3.2 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.8 3.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.8 3.1 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.8 6.2 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.8 3.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.8 4.5 GO:0042555 MCM complex(GO:0042555)
0.7 4.5 GO:0032126 eisosome(GO:0032126)
0.7 2.8 GO:0000817 COMA complex(GO:0000817)
0.7 2.8 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.7 11.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.7 2.0 GO:0000229 cytoplasmic chromosome(GO:0000229) mitochondrial chromosome(GO:0000262)
0.7 2.7 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.7 2.7 GO:0044611 nuclear pore inner ring(GO:0044611)
0.7 4.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.6 0.6 GO:0000145 exocyst(GO:0000145)
0.6 1.9 GO:0097344 Rix1 complex(GO:0097344)
0.6 7.5 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.6 4.7 GO:0017119 Golgi transport complex(GO:0017119)
0.5 2.2 GO:0031518 CBF3 complex(GO:0031518)
0.5 1.6 GO:0070545 PeBoW complex(GO:0070545)
0.5 3.8 GO:0000346 transcription export complex(GO:0000346)
0.5 2.1 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.5 1.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.5 1.5 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.5 2.0 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.5 0.5 GO:0030286 dynactin complex(GO:0005869) dynein complex(GO:0030286)
0.5 3.0 GO:0034455 t-UTP complex(GO:0034455)
0.5 2.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.5 2.8 GO:0000796 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.5 1.4 GO:0030869 RENT complex(GO:0030869)
0.5 1.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.5 36.1 GO:0009277 fungal-type cell wall(GO:0009277)
0.4 5.4 GO:0070938 actomyosin contractile ring(GO:0005826) contractile ring(GO:0070938)
0.4 28.8 GO:0000922 spindle pole(GO:0000922)
0.4 2.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.4 1.3 GO:0033186 CAF-1 complex(GO:0033186)
0.4 5.6 GO:0044433 cytoplasmic vesicle part(GO:0044433)
0.4 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.4 2.1 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.4 2.3 GO:0072686 mitotic spindle(GO:0072686)
0.4 3.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.4 2.7 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 1.9 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.4 2.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.4 2.9 GO:0030126 COPI vesicle coat(GO:0030126)
0.4 3.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.4 12.9 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.4 2.1 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.3 1.4 GO:0000938 GARP complex(GO:0000938)
0.3 4.2 GO:0030133 transport vesicle(GO:0030133)
0.3 1.9 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.3 3.8 GO:0030131 AP-type membrane coat adaptor complex(GO:0030119) clathrin adaptor complex(GO:0030131)
0.3 1.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 0.9 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.3 42.9 GO:0005933 cellular bud(GO:0005933)
0.3 5.1 GO:0016586 RSC complex(GO:0016586)
0.3 12.6 GO:0030686 90S preribosome(GO:0030686)
0.3 1.1 GO:0097196 Shu complex(GO:0097196)
0.3 0.8 GO:0070939 Dsl1p complex(GO:0070939)
0.3 1.6 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 3.2 GO:0098857 membrane raft(GO:0045121) membrane region(GO:0098589) membrane microdomain(GO:0098857)
0.3 0.8 GO:0016363 nuclear matrix(GO:0016363)
0.3 2.6 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.3 1.0 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.3 1.0 GO:0000811 GINS complex(GO:0000811)
0.3 1.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176) exosome (RNase complex)(GO:0000178)
0.2 1.2 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.2 1.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 1.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 0.7 GO:0043529 GET complex(GO:0043529)
0.2 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.2 2.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 0.7 GO:0070985 TFIIK complex(GO:0070985)
0.2 4.3 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.2 2.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 2.0 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.2 3.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 6.0 GO:0005844 polysome(GO:0005844)
0.2 7.2 GO:0043332 mating projection tip(GO:0043332)
0.2 0.4 GO:0032545 CURI complex(GO:0032545)
0.2 0.8 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.2 0.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 0.4 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.2 1.5 GO:0030008 TRAPP complex(GO:0030008)
0.2 1.1 GO:0032040 small-subunit processome(GO:0032040)
0.2 3.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.2 0.9 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.2 0.7 GO:0016587 Isw1 complex(GO:0016587)
0.2 2.0 GO:0032541 cortical endoplasmic reticulum(GO:0032541) endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.2 0.3 GO:0044815 DNA packaging complex(GO:0044815)
0.2 0.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 1.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 0.5 GO:0030427 site of polarized growth(GO:0030427)
0.1 0.4 GO:0031415 NatA complex(GO:0031415)
0.1 0.4 GO:0000792 heterochromatin(GO:0000792)
0.1 7.3 GO:0000139 Golgi membrane(GO:0000139)
0.1 0.4 GO:0097255 R2TP complex(GO:0097255)
0.1 0.8 GO:0016272 prefoldin complex(GO:0016272)
0.1 1.2 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.1 2.4 GO:0070847 core mediator complex(GO:0070847)
0.1 0.5 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 3.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 0.5 GO:0005819 spindle(GO:0005819)
0.1 0.8 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 0.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.0 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.1 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.1 5.2 GO:0005794 Golgi apparatus(GO:0005794)
0.1 0.9 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 3.2 GO:0005811 lipid particle(GO:0005811)
0.1 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 2.6 GO:0071010 U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.1 0.5 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.5 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 0.4 GO:0030867 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.1 0.3 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.1 0.2 GO:0000417 HIR complex(GO:0000417)
0.1 10.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 0.2 GO:0000243 commitment complex(GO:0000243)
0.1 0.2 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.2 GO:0045254 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.1 0.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 1.1 GO:0044445 cytosolic part(GO:0044445)
0.0 0.2 GO:0030897 HOPS complex(GO:0030897)
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 1.5 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.1 GO:0043601 replisome(GO:0030894) nuclear replisome(GO:0043601)
0.0 0.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.5 GO:0000502 proteasome complex(GO:0000502)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.1 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.6 GO:0070568 guanylyltransferase activity(GO:0070568)
2.3 58.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
2.2 8.7 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.9 5.6 GO:0070567 cytidylyltransferase activity(GO:0070567)
1.8 5.3 GO:0009922 fatty acid elongase activity(GO:0009922)
1.7 8.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.7 10.2 GO:0003993 acid phosphatase activity(GO:0003993)
1.6 11.2 GO:0008422 beta-glucosidase activity(GO:0008422)
1.6 6.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.6 4.7 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
1.5 6.0 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
1.5 4.4 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
1.4 4.3 GO:0051219 phosphoprotein binding(GO:0051219)
1.3 3.9 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.2 14.6 GO:0005199 structural constituent of cell wall(GO:0005199)
1.1 4.6 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.1 3.4 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
1.1 3.3 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
1.1 4.4 GO:0009378 four-way junction helicase activity(GO:0009378)
1.0 10.3 GO:0005216 ion channel activity(GO:0005216)
1.0 5.1 GO:0004707 MAP kinase activity(GO:0004707)
1.0 4.0 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
1.0 2.9 GO:0015248 sterol transporter activity(GO:0015248)
0.9 9.2 GO:0003777 microtubule motor activity(GO:0003777)
0.9 3.5 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.9 2.6 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.8 2.5 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.8 4.2 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.8 8.3 GO:0031386 protein tag(GO:0031386)
0.8 3.9 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.8 3.9 GO:0000146 microfilament motor activity(GO:0000146)
0.8 3.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.7 6.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.7 30.7 GO:0019843 rRNA binding(GO:0019843)
0.7 7.3 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.7 4.3 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.7 2.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.7 10.4 GO:0015926 glucosidase activity(GO:0015926)
0.7 11.7 GO:0001056 RNA polymerase III activity(GO:0001056)
0.7 2.7 GO:0004622 lysophospholipase activity(GO:0004622)
0.7 19.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.6 3.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.6 3.1 GO:0008312 7S RNA binding(GO:0008312)
0.6 1.8 GO:0019003 GDP binding(GO:0019003)
0.6 2.3 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.6 1.7 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.6 2.8 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.6 2.8 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.5 1.6 GO:0016872 intramolecular lyase activity(GO:0016872)
0.5 97.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 0.5 GO:0015645 fatty acid ligase activity(GO:0015645) very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.5 2.7 GO:0070300 phosphatidic acid binding(GO:0070300)
0.5 1.6 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.5 2.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.5 1.6 GO:0004100 chitin synthase activity(GO:0004100)
0.5 5.6 GO:0051015 actin filament binding(GO:0051015)
0.5 0.5 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.5 2.0 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.5 9.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.4 2.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.4 3.0 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.4 1.7 GO:0016841 ammonia-lyase activity(GO:0016841)
0.4 2.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.4 2.0 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.4 1.6 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 2.7 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.4 2.3 GO:0016408 C-acyltransferase activity(GO:0016408)
0.4 1.1 GO:0016504 peptidase activator activity(GO:0016504)
0.4 1.5 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.4 2.2 GO:0003774 motor activity(GO:0003774)
0.3 1.7 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.3 1.4 GO:0004771 sterol esterase activity(GO:0004771)
0.3 0.7 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.3 1.9 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.3 1.9 GO:0019237 centromeric DNA binding(GO:0019237)
0.3 4.2 GO:0070566 adenylyltransferase activity(GO:0070566)
0.3 1.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 3.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.3 0.9 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.3 0.9 GO:0003680 AT DNA binding(GO:0003680)
0.3 8.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.3 3.0 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.3 2.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 1.8 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.3 5.8 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.3 0.8 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.3 1.6 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.3 2.5 GO:0030276 clathrin binding(GO:0030276)
0.3 2.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.3 0.8 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.3 0.8 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.3 1.6 GO:0030145 manganese ion binding(GO:0030145)
0.3 1.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 1.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 2.5 GO:0019239 deaminase activity(GO:0019239)
0.2 2.2 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.2 1.7 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.2 2.2 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 0.7 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.2 7.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 3.9 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.2 1.6 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.2 2.0 GO:0043495 protein anchor(GO:0043495)
0.2 1.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 1.9 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.2 5.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 3.0 GO:0042803 protein homodimerization activity(GO:0042803)
0.2 1.0 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 5.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 1.0 GO:0019201 nucleotide kinase activity(GO:0019201)
0.2 0.8 GO:0019211 phosphatase activator activity(GO:0019211)
0.2 2.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 1.0 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.2 11.8 GO:0003924 GTPase activity(GO:0003924)
0.2 6.1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.2 0.8 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.2 9.7 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.2 0.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 1.4 GO:0005516 calmodulin binding(GO:0005516)
0.2 2.8 GO:0030515 snoRNA binding(GO:0030515)
0.2 0.9 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.2 1.0 GO:0016778 diphosphotransferase activity(GO:0016778)
0.2 2.7 GO:0015616 DNA translocase activity(GO:0015616)
0.2 1.2 GO:0003724 RNA helicase activity(GO:0003724)
0.2 0.5 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026) RNA polymerase I transcription factor binding(GO:0001179)
0.2 1.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 1.1 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 0.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 2.2 GO:0001671 ATPase activator activity(GO:0001671)
0.2 0.8 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.9 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.4 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 0.3 GO:0072341 modified amino acid binding(GO:0072341)
0.1 0.4 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.1 1.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.4 GO:0019901 protein kinase binding(GO:0019901)
0.1 0.5 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.1 2.9 GO:0005048 signal sequence binding(GO:0005048)
0.1 2.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 3.7 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.6 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.2 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.1 1.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 1.0 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.4 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.9 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.4 GO:0008252 nucleotidase activity(GO:0008252)
0.1 0.6 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 2.8 GO:0051540 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.1 0.9 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.1 1.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.9 GO:0019904 protein domain specific binding(GO:0019904)
0.1 0.3 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.1 0.7 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 4.0 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.3 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 1.0 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1 0.5 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.6 GO:0000049 tRNA binding(GO:0000049)
0.1 0.2 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 1.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.2 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.1 0.3 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 0.2 GO:0019202 amino acid kinase activity(GO:0019202)
0.1 0.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 0.1 GO:0000403 Y-form DNA binding(GO:0000403)
0.1 0.1 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.7 GO:0050661 NADP binding(GO:0050661)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.2 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.2 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.5 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
0.0 0.5 GO:0019207 kinase regulator activity(GO:0019207)
0.0 0.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0004620 phospholipase activity(GO:0004620)
0.0 0.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.0 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 2.6 GO:0003723 RNA binding(GO:0003723)
0.0 0.1 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 0.0 GO:0000404 heteroduplex DNA loop binding(GO:0000404) DNA insertion or deletion binding(GO:0032135)
0.0 0.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.0 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.9 2.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.7 3.7 PID PLK1 PATHWAY PLK1 signaling events
0.7 2.2 PID SHP2 PATHWAY SHP2 signaling
0.7 0.7 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.7 2.6 PID E2F PATHWAY E2F transcription factor network
0.5 1.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4 0.8 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.4 1.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 1.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 1.0 PID P73PATHWAY p73 transcription factor network
0.2 0.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 0.7 PID AURORA B PATHWAY Aurora B signaling
0.2 0.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 2.0 PID ATR PATHWAY ATR signaling pathway
0.2 0.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 0.1 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.2 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.0 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 13.8 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
1.4 22.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
1.3 5.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
1.2 1.2 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
1.0 2.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.9 2.7 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.9 2.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.9 1.7 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.7 4.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.6 1.2 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.6 1.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.6 1.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.6 0.6 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.5 5.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 1.9 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.4 0.8 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.4 2.3 REACTOME TRANSLATION Genes involved in Translation
0.4 1.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 0.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 1.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.3 1.0 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.2 3.8 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.2 0.4 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.2 1.3 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.1 0.1 REACTOME CELL CYCLE MITOTIC Genes involved in Cell Cycle, Mitotic
0.1 0.9 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 0.5 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
0.1 0.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 0.2 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.0 0.0 REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.0 0.5 REACTOME HIV INFECTION Genes involved in HIV Infection
0.0 0.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling