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Results for GAT3

Z-value: 0.33

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Transcription factors associated with GAT3

Gene Symbol Gene ID Gene Info
GAT3
S000004003 Protein containing GATA family zinc finger motifs

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GAT3YLR013W0.385.4e-02Click!

Activity profile of GAT3 motif

Sorted Z-values of GAT3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YKL217W 1.28
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YPL223C 1.11
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YFR053C 1.07
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YHR139C 0.99
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YER103W 0.98
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YOR343C 0.97 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YKR097W 0.95
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YFL052W 0.93 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YPL250C 0.92
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YJR146W 0.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YGL255W 0.87
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YEL039C 0.85
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YML128C 0.84
MSC1
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YEL070W 0.80
DSF1
Deletion suppressor of mpt5 mutation
YPL054W 0.77
LEE1
Zinc-finger protein of unknown function
YFR017C 0.76 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YNR034W-A 0.75 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YJR078W 0.70
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YBR072W 0.68
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YHR096C 0.68
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YIL057C 0.67 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YEL008W 0.65 Hypothetical protein predicted to be involved in metabolism
YAR060C 0.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR248W 0.64
SOL4
6-phosphogluconolactonase with similarity to Sol3p
YDR453C 0.63
TSA2
Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YML054C 0.61
CYB2
Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YAL054C 0.61
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YIL012W 0.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR139C-A 0.58 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR316C-B 0.58 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR023W 0.57
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YJL217W 0.57 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YMR317W 0.57 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YHL021C 0.56
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YDR536W 0.56
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YJR077C 0.55
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YNL052W 0.53
COX5A
Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YNL074C 0.52
MLF3
Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YLR296W 0.50 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR312C 0.49
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YGR191W 0.49
HIP1
High-affinity histidine permease, also involved in the transport of manganese ions
YAR053W 0.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR375W 0.48
STP3
Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YNL042W-B 0.48 Putative protein of unknown function
YJR048W 0.48
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YOR178C 0.48
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YOL154W 0.47
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YDR530C 0.47
APA2
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YPL156C 0.46
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YGR022C 0.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YLL026W 0.46
HSP104
Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YHR092C 0.45
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YJL067W 0.45 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR030W 0.45
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YIR027C 0.44
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YML100W 0.44
TSL1
Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YGR043C 0.44
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YBR214W 0.44
SDS24
One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YJL045W 0.44 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YHR212C 0.43 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR332W 0.43
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YCR021C 0.43
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YBR132C 0.42
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YPL222W 0.42
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR235W 0.42
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YNL036W 0.42
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YAR019C 0.41
CDC15
Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YLR331C 0.40
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YBR077C 0.40
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YDR171W 0.39
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YGL162W 0.39
SUT1
Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression
YDL085W 0.38
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YBR085C-A 0.38 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YNL142W 0.38
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YNL055C 0.38
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YOR348C 0.38
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YEL009C 0.37
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YIL037C 0.37
PRM2
Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p
YOL032W 0.37
OPI10
Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline
YNL125C 0.36
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YNL144C 0.36 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YDL181W 0.36
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YPL262W 0.36
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YLR374C 0.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
YLR294C 0.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
YBR145W 0.35
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YGR213C 0.35
RTA1
Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions
YHR212W-A 0.35 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YJL144W 0.35 Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YKL163W 0.35
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YPR160W 0.35
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YKR011C 0.34 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YKL100C 0.34 Putative protein of unknown function with similarity to a human minor histocompatibility antigen; YKL100C is not an essential gene
YGR069W 0.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR268C 0.34
HUA1
Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YOL119C 0.33
MCH4
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YBL099W 0.33
ATP1
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YMR191W 0.33
SPG5
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YHR086W 0.33
NAM8
RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA
YOL118C 0.33 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YIL059C 0.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YER147C 0.32
SCC4
Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
YNL093W 0.32
YPT53
GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YJR150C 0.32
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YPR027C 0.32 Putative protein of unknown function
YAR050W 0.31
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YFL051C 0.31 Putative protein of unknown function; YFL051C is not an essential gene
YOR298C-A 0.31
MBF1
Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
YOR152C 0.31 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YGR070W 0.31
ROM1
GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YJR147W 0.31
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YIL047C 0.31
SYG1
Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YAR047C 0.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR190C 0.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YDR034C 0.30
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YGL140C 0.30 Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
YJL093C 0.30
TOK1
Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YLL019C 0.30
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YBL100C 0.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YLR311C 0.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR295C 0.28
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YIL046W-A 0.28 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YGR149W 0.28 Putative protein of unknown function; predicted to be an integal membrane protein
YMR280C 0.28
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YCL048W-A 0.28 Putative protein of unknown function
YGR279C 0.27
SCW4
Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YFL039C 0.27
ACT1
Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YBL015W 0.27
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YPR061C 0.27
JID1
Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YNR055C 0.27
HOL1
Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake
YKL051W 0.27
SFK1
Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YGR197C 0.27
SNG1
Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance
YPR106W 0.27
ISR1
Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
YGL262W 0.27 Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
YDR059C 0.26
UBC5
Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YDR540C 0.26
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YKR042W 0.26
UTH1
Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death
YPR191W 0.26
QCR2
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YGL114W 0.26 Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YBR108W 0.26
AIM3
Protein interacting with Rsv167p; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YNL037C 0.26
IDH1
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YIL060W 0.25 Putative protein of unknown function; mutant accumulates less glycogen than does wild type; YIL060W is not an essential gene
YML087C 0.25
AIM33
Putative protein of unknown function; highly conserved across species and orthologous to human CYB5R4; null mutant shows increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YLR297W 0.25 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YAR019W-A 0.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR020W 0.25
ATP20
Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
YJR151C 0.25
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YCL001W-B 0.24 Putative protein of unknown function; identified by homology
YIL147C 0.24
SLN1
Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
YML131W 0.24 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YER163C 0.24 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YHR145C 0.24 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR412C-A 0.24 Putative protein of unknown function
YGR250C 0.24 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR315W 0.24
NKP2
Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)
YDR342C 0.24
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YJR152W 0.23
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YBR056W-A 0.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YDR322C-A 0.23
TIM11
Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase
YDR445C 0.23 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR142W 0.23
BTN2
v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YKL044W 0.23 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL224C 0.23
WHI4
Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division
YOR100C 0.22
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YPR028W 0.22
YOP1
Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells
YPL271W 0.22
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YKL148C 0.22
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YDR446W 0.22
ECM11
Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
YEL011W 0.22
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YIL162W 0.22
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YDR250C 0.22 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOR379C 0.22 Hypothetical protein
YMR020W 0.22
FMS1
Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
YKL103C 0.22
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YKL220C 0.21
FRE2
Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
YPL018W 0.21
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YJR148W 0.21
BAT2
Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
YPL224C 0.21
MMT2
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
YPR015C 0.21 Putative protein of unknown function
YBR076C-A 0.21 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YHR002W 0.21
LEU5
Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized
YDR533C 0.21
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YBL074C 0.20
AAR2
Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
YER065C 0.20
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YGR067C 0.20 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YNL276C 0.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W
YAR023C 0.20 Putative integral membrane protein, member of DUP240 gene family
YBR060C 0.20
ORC2
Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
YMR189W 0.20
GCV2
P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
YLR037C 0.20
DAN2
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YOR378W 0.20 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YBL073W 0.20 Hypothetical protein; open reading frame overlaps 5' end of essential AAR2 gene encoding a component of the U5 snRNP required for splicing of U3 precursors
YGR236C 0.20
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR203C 0.20
MSS51
Nuclear encoded protein required for translation of COX1 mRNA; binds to Cox1 protein
YER004W 0.20
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR272C 0.20
SCS7
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YOR231W 0.19
MKK1
Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p
YPL058C 0.19
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YBL049W 0.19
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YKL177W 0.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3

Network of associatons between targets according to the STRING database.

First level regulatory network of GAT3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0015755 fructose transport(GO:0015755)
0.3 1.3 GO:0006848 pyruvate transport(GO:0006848)
0.3 0.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 0.7 GO:0043335 protein unfolding(GO:0043335)
0.2 2.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 0.6 GO:0035786 protein complex oligomerization(GO:0035786)
0.2 0.2 GO:0034225 cellular response to zinc ion starvation(GO:0034224) regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation(GO:0034225)
0.2 0.8 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 0.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.5 GO:0015976 carbon utilization(GO:0015976)
0.1 0.6 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 1.1 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.4 GO:0050685 positive regulation of mRNA processing(GO:0050685)
0.1 0.8 GO:0006083 acetate metabolic process(GO:0006083)
0.1 0.7 GO:0045117 azole transport(GO:0045117)
0.1 0.4 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.1 0.8 GO:0019655 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.1 0.4 GO:0032371 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.1 0.3 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 0.6 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.3 GO:0035948 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.1 0.3 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.1 0.7 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.1 0.4 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 0.6 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.1 0.4 GO:0046351 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 0.3 GO:0030048 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 1.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.3 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.1 0.7 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.5 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.3 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 0.3 GO:0044070 regulation of anion transport(GO:0044070)
0.1 0.3 GO:0006074 (1->3)-beta-D-glucan metabolic process(GO:0006074)
0.1 0.3 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.1 0.3 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.1 0.2 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.1 0.3 GO:0015793 glycerol transport(GO:0015793)
0.1 0.2 GO:0006546 glycine catabolic process(GO:0006546)
0.1 0.6 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 0.3 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.1 0.5 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.2 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 1.1 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.1 0.3 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.8 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.0 0.3 GO:0051322 anaphase(GO:0051322)
0.0 0.1 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.0 0.2 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.0 0.5 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.4 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.1 GO:0072529 pyrimidine-containing compound catabolic process(GO:0072529)
0.0 0.1 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.0 0.2 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.3 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.2 GO:0046688 response to copper ion(GO:0046688)
0.0 0.7 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 1.0 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.2 GO:0051503 adenine nucleotide transport(GO:0051503)
0.0 0.0 GO:0060631 regulation of meiosis I(GO:0060631)
0.0 1.0 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.1 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.4 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.0 0.1 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.0 0.2 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.1 GO:0000435 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0036257 multivesicular body organization(GO:0036257)
0.0 0.2 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.0 0.1 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.0 0.1 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.3 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.1 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.0 0.3 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.0 0.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.2 GO:0006113 fermentation(GO:0006113)
0.0 0.1 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.0 0.5 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.0 0.1 GO:0019627 urea metabolic process(GO:0019627)
0.0 0.1 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.0 0.2 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.3 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.2 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.2 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.2 GO:0042819 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.2 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.1 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.0 0.1 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.0 0.1 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.1 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.1 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.3 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.1 GO:0000736 removal of nonhomologous ends(GO:0000735) double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.0 0.1 GO:0070814 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.0 0.2 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.1 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.1 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0055088 lipid homeostasis(GO:0055088)
0.0 0.3 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.1 GO:0006452 translational frameshifting(GO:0006452)
0.0 0.4 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.2 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 0.0 GO:0006032 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0 1.1 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.1 GO:0000755 cytogamy(GO:0000755)
0.0 0.0 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.2 GO:0006826 iron ion transport(GO:0006826)
0.0 0.1 GO:0006545 glycine biosynthetic process(GO:0006545)
0.0 0.1 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.0 GO:1900461 positive regulation of cell growth(GO:0030307) positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter(GO:1900461) positive regulation of pseudohyphal growth(GO:2000222)
0.0 0.1 GO:0044209 AMP salvage(GO:0044209)
0.0 0.7 GO:0070726 cell wall assembly(GO:0070726)
0.0 0.1 GO:1903138 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.0 0.0 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.1 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.0 0.1 GO:0032973 amino acid export(GO:0032973) amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.0 0.1 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0032261 purine nucleotide salvage(GO:0032261)
0.0 0.1 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.1 GO:0042744 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.0 0.1 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.0 0.2 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.0 0.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.0 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.0 0.3 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.3 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.0 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.1 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.0 0.0 GO:0006000 fructose metabolic process(GO:0006000)
0.0 0.2 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.0 GO:0090399 replicative senescence(GO:0090399)
0.0 0.1 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.1 GO:0032120 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.0 0.0 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.0 0.1 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.0 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.0 0.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.1 GO:0006276 plasmid maintenance(GO:0006276)
0.0 0.0 GO:0006183 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.0 0.0 GO:0034204 lipid translocation(GO:0034204) regulation of membrane lipid distribution(GO:0097035)
0.0 0.0 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.0 0.1 GO:0019400 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.0 0.1 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.0 0.1 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.1 GO:0045010 positive regulation of actin filament polymerization(GO:0030838) actin nucleation(GO:0045010)
0.0 0.1 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.0 0.0 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.0 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.0 0.0 GO:0006108 malate metabolic process(GO:0006108)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 GO:0070469 respiratory chain(GO:0070469)
0.1 0.6 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.3 GO:0046930 pore complex(GO:0046930)
0.1 2.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.6 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.5 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 0.4 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 0.3 GO:0032116 SMC loading complex(GO:0032116)
0.1 0.2 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.3 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 0.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.2 GO:0000817 COMA complex(GO:0000817)
0.0 0.1 GO:0034099 luminal surveillance complex(GO:0034099)
0.0 0.1 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.0 0.6 GO:0031160 spore wall(GO:0031160)
0.0 0.1 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.7 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.0 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.0 0.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.1 GO:0030428 cell septum(GO:0030428)
0.0 0.1 GO:0034448 EGO complex(GO:0034448)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.0 0.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.2 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.1 GO:0030139 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.1 GO:0044232 ERMES complex(GO:0032865) organelle membrane contact site(GO:0044232) ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.6 GO:0005770 late endosome(GO:0005770)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.1 GO:0008623 CHRAC(GO:0008623)
0.0 1.0 GO:0009277 fungal-type cell wall(GO:0009277)
0.0 0.0 GO:0030312 cell wall(GO:0005618) external encapsulating structure(GO:0030312)
0.0 0.2 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 0.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.0 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0005677 chromatin silencing complex(GO:0005677)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0015295 solute:proton symporter activity(GO:0015295)
0.3 1.1 GO:0004396 hexokinase activity(GO:0004396)
0.2 0.8 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.2 0.7 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 2.8 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.2 0.5 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.2 0.6 GO:0005537 mannose binding(GO:0005537)
0.1 0.4 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.1 0.4 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.7 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.3 GO:0015288 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.1 0.3 GO:0016289 CoA hydrolase activity(GO:0016289)
0.1 0.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.7 GO:0005216 ion channel activity(GO:0005216)
0.1 0.3 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.1 1.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 1.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.2 GO:0022838 substrate-specific channel activity(GO:0022838)
0.1 0.8 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.4 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 0.2 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.1 0.1 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.1 0.5 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.1 0.4 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 0.3 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.1 0.9 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.1 0.1 GO:0015294 solute:cation symporter activity(GO:0015294)
0.1 0.5 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.3 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 0.1 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.1 0.2 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.1 0.2 GO:0004375 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.1 0.5 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 0.1 GO:0031072 heat shock protein binding(GO:0031072)
0.1 0.3 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.1 0.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.2 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.0 0.1 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.6 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.6 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.0 0.3 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.0 0.4 GO:0099600 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.0 0.0 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.2 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.0 0.1 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.0 0.1 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.1 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.0 0.2 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.0 1.1 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.3 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.0 0.1 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.0 0.2 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.0 0.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.2 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.0 0.6 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.1 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.2 GO:0000149 SNARE binding(GO:0000149)
0.0 0.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.1 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.1 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.0 0.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.1 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091) TFIID-class transcription factor binding(GO:0001094)
0.0 1.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.0 0.1 GO:0004629 phospholipase C activity(GO:0004629)
0.0 0.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0 0.3 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.1 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.2 GO:0050661 NADP binding(GO:0050661)
0.0 0.7 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 0.1 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.0 0.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.4 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.0 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.0 0.0 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.0 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.0 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.0 0.2 GO:0043022 ribosome binding(GO:0043022)
0.0 0.1 GO:0010181 FMN binding(GO:0010181)
0.0 0.1 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 0.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.1 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.2 PID FANCONI PATHWAY Fanconi anemia pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 1.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.1 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 0.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.1 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 0.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.0 REACTOME MEIOSIS Genes involved in Meiosis