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Results for GCN4

Z-value: 1.05

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Transcription factors associated with GCN4

Gene Symbol Gene ID Gene Info
GCN4
S000000735 bZIP transcriptional activator of amino acid biosynthetic genes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GCN4YEL009C0.815.0e-07Click!

Activity profile of GCN4 motif

Sorted Z-values of GCN4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YLR307C-A 9.02 Putative protein of unknown function
YPL250C 6.69
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YAR053W 6.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR096W 5.61
SNZ1
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YAR060C 4.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL104C 4.54
LEU4
Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YHR212C 4.03 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR116C 3.96 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YJL088W 3.77
ARG3
Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
YMR107W 3.74
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YLR356W 3.71 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YPR036W-A 3.66 Protein of unknown function; transcription is regulated by Pdr1p
YMR095C 3.66
SNO1
Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
YBR145W 3.56
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YDL182W 3.55
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YPL092W 3.48
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YJR146W 3.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YKL217W 3.46
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YHR212W-A 3.40 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLR327C 3.40
TMA10
Protein of unknown function that associates with ribosomes
YER068C-A 3.38 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL162W 3.21
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YER069W 3.16
ARG5,6
Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p
YCL030C 2.94
HIS4
Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
YHR071W 2.86
PCL5
Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YOL058W 2.82
ARG1
Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
YPR184W 2.74
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YBR147W 2.67
RTC2
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YDR540C 2.67
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YFR052C-A 2.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR533C 2.59
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YNL005C 2.57
MRP7
Mitochondrial ribosomal protein of the large subunit
YPL018W 2.49
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YKL016C 2.46
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDL067C 2.27
COX9
Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YDL183C 2.24 Putative protein of unknown function; YDL183C is not an essential gene
YGL184C 2.20
STR3
Cystathionine beta-lyase, converts cystathionine into homocysteine
YHL046W-A 2.18 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR095W 2.17
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YFL051C 2.14 Putative protein of unknown function; YFL051C is not an essential gene
YER175C 2.12
TMT1
Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
YGR065C 2.10
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YDL170W 2.03
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YIR034C 1.93
LYS1
Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway
YER024W 1.91
YAT2
Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YKL103C 1.84
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YHR048W 1.81
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YHL047C 1.79
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YNR069C 1.76
BSC5
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YHL036W 1.75
MUP3
Low affinity methionine permease, similar to Mup1p
YCR005C 1.74
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YNL036W 1.67
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YER065C 1.62
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YOR100C 1.62
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YAL062W 1.60
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YNL183C 1.59
NPR1
Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation
YOL118C 1.58 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YHR092C 1.57
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YKL102C 1.55 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YMR081C 1.54
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YJR147W 1.53
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YJL133C-A 1.50 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR050C 1.50
LYS9
Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YNL125C 1.50
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YFR029W 1.49
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YAR050W 1.49
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YJL199C 1.47
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YPL135W 1.45
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YOL140W 1.44
ARG8
Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
YFR053C 1.43
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YJR109C 1.42
CPA2
Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
YLR152C 1.40 Putative protein of unknown function; YLR152C is not an essential gene
YER175W-A 1.39 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPR010C-A 1.39 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YAR047C 1.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR191W 1.35
HIP1
High-affinity histidine permease, also involved in the transport of manganese ions
YOL119C 1.31
MCH4
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YDR258C 1.31
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YBR218C 1.29
PYC2
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YBR250W 1.25
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YJR048W 1.23
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YGL059W 1.20
PKP2
Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p
YHL040C 1.19
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YDR010C 1.18 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL047C 1.15
SYG1
Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YGR190C 1.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YML076C 1.13
WAR1
Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
YDR342C 1.12
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YMR114C 1.10 Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
YIL057C 1.10 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YOL025W 1.06
LAG2
Protein involved in determination of longevity; LAG2 gene is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells
YDR453C 1.06
TSA2
Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YGR258C 1.02
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YKR097W 1.01
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YDL085W 0.99
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YMR013C 0.99
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YNL037C 0.99
IDH1
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YCR023C 0.99 Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
YGL219C 0.97
MDM34
Mitochondrial outer membrane protein, required for normal mitochondrial morphology and inheritance; localizes to dots on the mitochondrial surface near mtDNA nucleoids; interacts genetically with MDM31 and MDM32
YER039C-A 0.96 Putative protein of unknown function; YER039C-A is not an essential gene
YBR169C 0.96
SSE2
Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p
YJL185C 0.95 Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene
YFL030W 0.94
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YNL013C 0.93 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
YLL055W 0.91
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YKL112W 0.90
ABF1
DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
YJL213W 0.90 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YLL029W 0.90
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YJR122W 0.89
IBA57
Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system
YBR144C 0.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
YMR063W 0.89
RIM9
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein
YBR293W 0.88
VBA2
Permease of basic amino acids in the vacuolar membrane
YGR260W 0.88
TNA1
High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YNL240C 0.86
NAR1
Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YPL036W 0.86
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YGL072C 0.85 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YEL059W 0.85 Dubious open reading frame unlikely to encode a functional protein
YGR286C 0.84
BIO2
Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YDL244W 0.84
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YGL117W 0.82 Putative protein of unknown function
YFR047C 0.81
BNA6
Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YBL033C 0.81
RIB1
GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YLL056C 0.81 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YLR023C 0.79
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YOR227W 0.77 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR336W 0.77
KRE5
Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
YGR142W 0.76
BTN2
v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YOR066W 0.75
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YHR161C 0.75
YAP1801
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family
YKL071W 0.75 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGL236C 0.74
MTO1
Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
YMR118C 0.74 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YIR017C 0.74
MET28
Transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
YGL045W 0.74
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YHR180W 0.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR196W 0.73 Putative maltose activator
YDR542W 0.73
PAU10
Hypothetical protein
YGL180W 0.72
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YBR008C 0.72
FLR1
Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs
YHR139C 0.71
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YPL033C 0.71 Putative protein of unknown function; may be involved in DNA metabolism; expression is induced by Kar4p
YLR193C 0.69
UPS1
Mitochondrial intermembrane space protein that regulates alternative processing and sorting of Mgm1p and other proteins; required for normal mitochondrial morphology; ortholog of human PRELI
YJR130C 0.69
STR2
Cystathionine gamma-synthase, converts cysteine into cystathionine
YNL094W 0.69
APP1
Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization
YPL264C 0.68 Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene
YNL103W 0.68
MET4
Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
YMR135C 0.68
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YPL006W 0.67
NCR1
Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
YHR151C 0.66
MTC6
Putative protein of unknown function; YHR151C is synthetically sick with cdc13-1
YGL062W 0.66
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YDR525W-A 0.65
SNA2
Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBR292C 0.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YDR034C 0.65
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YKL167C 0.64
MRP49
Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
YBL102W 0.63
SFT2
Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
YER066W 0.63 Putative protein of unknown function; YER066W is not an essential gene
YNL220W 0.63
ADE12
Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
YER101C 0.62
AST2
Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YDL218W 0.62 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YLL047W 0.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
YOL117W 0.61
RRI2
Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response
YDR541C 0.60 Putative dihydrokaempferol 4-reductase
YEL044W 0.60
IES6
Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YKL224C 0.60
PAU16
Putative protein of unknown function
YJL100W 0.60
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YMR206W 0.60 Putative protein of unknown function; YMR206W is not an essential gene
YMR253C 0.59 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
YDR476C 0.59 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YBR035C 0.59
PDX3
Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YBR037C 0.59
SCO1
Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins
YPL230W 0.59
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YGL255W 0.58
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YNL095C 0.57 Putative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene
YGR087C 0.56
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YOR255W 0.56
OSW1
Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p
YPR027C 0.56 Putative protein of unknown function
YDL194W 0.56
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YBR105C 0.55
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YOR346W 0.55
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YGR273C 0.54 Putative protein of unknown function; deletion mutant has no readily detectable phenotype; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation
YFL025C 0.54
BST1
GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
YJL089W 0.54
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YIL060W 0.54 Putative protein of unknown function; mutant accumulates less glycogen than does wild type; YIL060W is not an essential gene
YPL183W-A 0.54
RTC6
Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome; null mutation suppresses cdc13-1 temperature sensitivity
YLR228C 0.54
ECM22
Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YCL048W 0.53
SPS22
Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YBL049W 0.53
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YIR039C 0.53
YPS6
Putative GPI-anchored aspartic protease
YPL229W 0.53 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene
YJL170C 0.53
ASG7
Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor
YIR018W 0.52
YAP5
Basic leucine zipper (bZIP) transcription factor
YGL170C 0.52
SPO74
Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
YOR192C 0.52
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YOL026C 0.50
MIM1
Mitochondrial outer membrane protein, required for assembly of the translocase of the outer membrane (TOM) complex and thereby for mitochondrial protein import; N terminus is exposed to the cytosol: transmembrane segment is highly conserved
YPL017C 0.50
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YGL141W 0.50
HUL5
Ubiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins; works in opposition to Ubp6p polyubiquitin-shortening activity; required for retrograde transport of misfolded proteins into cytoplasm during ERAD
YKR098C 0.50
UBP11
Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
YMR170C 0.49
ALD2
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YLR058C 0.49
SHM2
Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
YJL210W 0.48
PEX2
RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import

Network of associatons between targets according to the STRING database.

First level regulatory network of GCN4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0006592 ornithine biosynthetic process(GO:0006592)
1.2 9.9 GO:0042819 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.9 3.5 GO:0006848 pyruvate transport(GO:0006848)
0.8 3.2 GO:0015976 carbon utilization(GO:0015976)
0.7 7.4 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.7 5.7 GO:0006526 arginine biosynthetic process(GO:0006526)
0.7 1.3 GO:0045117 azole transport(GO:0045117)
0.7 2.0 GO:0015755 fructose transport(GO:0015755)
0.7 4.6 GO:0019655 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.6 1.9 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.6 2.9 GO:0043433 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108) negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.5 2.7 GO:0005980 glycogen catabolic process(GO:0005980)
0.5 2.7 GO:0044746 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.5 1.5 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.5 2.0 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.5 7.6 GO:0072348 sulfur compound transport(GO:0072348)
0.5 1.0 GO:0006102 isocitrate metabolic process(GO:0006102)
0.5 1.4 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.5 1.4 GO:0006545 glycine biosynthetic process(GO:0006545)
0.4 1.8 GO:0019748 secondary metabolic process(GO:0019748)
0.4 3.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 1.3 GO:0043335 protein unfolding(GO:0043335)
0.4 3.2 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.4 1.5 GO:0043200 response to amino acid(GO:0043200)
0.4 3.3 GO:0006097 glyoxylate cycle(GO:0006097)
0.3 2.4 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.3 7.5 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.3 1.8 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.3 0.6 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.3 0.5 GO:0061414 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.2 1.0 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.2 3.8 GO:0006754 ATP biosynthetic process(GO:0006754)
0.2 1.2 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.2 0.9 GO:0042743 hydrogen peroxide metabolic process(GO:0042743)
0.2 1.1 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.2 1.0 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.2 2.2 GO:0015893 drug transport(GO:0015893)
0.2 0.6 GO:0070583 spore membrane bending pathway(GO:0070583)
0.2 0.6 GO:0019627 urea metabolic process(GO:0019627)
0.2 1.0 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.2 0.6 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.2 2.6 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.2 0.6 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.2 1.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.2 1.2 GO:0015891 siderophore transport(GO:0015891)
0.1 0.4 GO:0051238 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 0.5 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 2.5 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.1 0.5 GO:0000200 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.1 0.5 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.1 0.4 GO:0051352 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.1 1.3 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.2 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.1 0.9 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.2 GO:2001038 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.1 0.6 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.4 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 3.3 GO:0006865 amino acid transport(GO:0006865)
0.1 0.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.3 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.1 0.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.5 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 0.4 GO:0000435 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.1 0.4 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
0.1 0.5 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 1.0 GO:0051181 cofactor transport(GO:0051181)
0.1 0.7 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.5 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.1 0.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.8 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.1 0.5 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 0.2 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 3.0 GO:0071940 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.3 GO:0071168 protein localization to chromatin(GO:0071168)
0.1 0.6 GO:0006825 copper ion transport(GO:0006825)
0.1 1.1 GO:0001101 response to acid chemical(GO:0001101)
0.1 0.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 0.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061395) cellular response to arsenic-containing substance(GO:0071243) negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.5 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.2 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.1 0.3 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.1 1.9 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.3 GO:0043605 cellular amide catabolic process(GO:0043605)
0.1 0.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 0.2 GO:0001109 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.1 1.0 GO:0015914 phospholipid transport(GO:0015914)
0.1 0.1 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.5 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.5 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 0.9 GO:0006094 gluconeogenesis(GO:0006094)
0.1 0.4 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.3 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196) regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.1 0.2 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.4 GO:0000105 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.0 0.4 GO:0006826 iron ion transport(GO:0006826)
0.0 0.6 GO:0042026 protein refolding(GO:0042026)
0.0 0.2 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.4 GO:0000755 cytogamy(GO:0000755)
0.0 0.2 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.2 GO:0043954 cellular component maintenance(GO:0043954)
0.0 0.0 GO:0010446 response to alkaline pH(GO:0010446) cellular response to alkaline pH(GO:0071469)
0.0 0.2 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.2 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 0.1 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.2 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.5 GO:0015849 organic acid transport(GO:0015849)
0.0 0.1 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.0 0.1 GO:0030491 heteroduplex formation(GO:0030491)
0.0 0.7 GO:0006869 lipid transport(GO:0006869)
0.0 0.2 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.2 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.4 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.0 0.1 GO:0042407 cristae formation(GO:0042407)
0.0 0.5 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.1 GO:0000348 mRNA branch site recognition(GO:0000348)
0.0 0.2 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.2 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 1.0 GO:0030437 ascospore formation(GO:0030437) cell development(GO:0048468)
0.0 0.2 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.0 0.4 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.1 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 2.1 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.4 GO:0031503 protein complex localization(GO:0031503)
0.0 0.1 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.1 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.2 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.2 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.1 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.0 0.2 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0006279 premeiotic DNA replication(GO:0006279)
0.0 0.1 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.1 GO:0045833 negative regulation of lipid metabolic process(GO:0045833)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.8 2.5 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.6 2.5 GO:0000817 COMA complex(GO:0000817)
0.3 1.7 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.3 2.7 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.3 0.8 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 0.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 1.0 GO:0044233 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.2 1.2 GO:0034657 GID complex(GO:0034657)
0.1 1.0 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 0.3 GO:0032126 eisosome(GO:0032126)
0.1 1.8 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.6 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.3 GO:0031160 spore wall(GO:0031160)
0.1 3.4 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 1.2 GO:0070469 respiratory chain(GO:0070469)
0.1 1.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 0.4 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 0.5 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 1.2 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.2 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 22.5 GO:0005886 plasma membrane(GO:0005886)
0.1 0.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.3 GO:0033263 CORVET complex(GO:0033263)
0.0 0.3 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 2.8 GO:0005576 extracellular region(GO:0005576)
0.0 2.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.1 GO:0044284 mitochondrial crista junction(GO:0044284)
0.0 0.7 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.0 2.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0032116 SMC loading complex(GO:0032116)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0070274 RES complex(GO:0070274)
0.0 0.1 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.0 0.2 GO:0034967 Set3 complex(GO:0034967)
0.0 0.2 GO:0071013 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013) post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.1 GO:0071819 DUBm complex(GO:0071819)
0.0 0.1 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.0 0.7 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.2 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.1 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.2 GO:0005769 early endosome(GO:0005769)
0.0 2.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.0 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.9 2.7 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.7 3.0 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.7 8.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.7 2.2 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.7 3.5 GO:0015295 solute:proton symporter activity(GO:0015295)
0.6 1.9 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.6 4.8 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.5 2.7 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.5 2.1 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.5 2.1 GO:0005537 mannose binding(GO:0005537)
0.5 2.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.5 2.9 GO:0016597 amino acid binding(GO:0016597)
0.5 1.4 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.5 3.2 GO:0019238 cyclohydrolase activity(GO:0019238)
0.4 4.9 GO:0015293 symporter activity(GO:0015293)
0.4 2.7 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.4 2.6 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.4 3.2 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.4 1.6 GO:0004396 hexokinase activity(GO:0004396)
0.4 1.4 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.4 0.7 GO:0045118 azole transporter activity(GO:0045118)
0.3 0.3 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.3 1.0 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 9.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.3 1.4 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.3 2.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 3.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 1.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 0.7 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.2 1.0 GO:0008198 ferrous iron binding(GO:0008198)
0.2 0.6 GO:0005536 glucose binding(GO:0005536)
0.2 0.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 0.7 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.2 0.8 GO:0016783 sulfurtransferase activity(GO:0016783)
0.2 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 0.6 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 1.0 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.6 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.6 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.1 1.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.5 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 5.7 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 1.3 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.1 0.3 GO:0016289 CoA hydrolase activity(GO:0016289)
0.1 0.8 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 3.2 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.1 0.3 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.1 GO:0072341 modified amino acid binding(GO:0072341)
0.1 0.9 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 0.9 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 0.3 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 1.5 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 0.4 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 0.4 GO:0016417 S-acyltransferase activity(GO:0016417)
0.1 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.1 0.8 GO:0000149 SNARE binding(GO:0000149)
0.1 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.7 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 2.7 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.1 0.6 GO:0010181 FMN binding(GO:0010181)
0.1 0.4 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.8 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 0.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.7 GO:0030276 clathrin binding(GO:0030276)
0.1 1.1 GO:0015297 antiporter activity(GO:0015297)
0.1 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.8 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.2 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 0.1 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)
0.1 0.6 GO:0038023 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.1 0.3 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.1 0.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.2 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.1 0.2 GO:0004458 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.0 0.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.6 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.6 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.2 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.2 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.3 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.4 GO:0004620 phospholipase activity(GO:0004620)
0.0 0.4 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.0 0.1 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.0 0.1 GO:0032183 SUMO binding(GO:0032183)
0.0 0.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.3 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.4 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 1.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.1 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.2 GO:0016298 lipase activity(GO:0016298)
0.0 0.1 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.1 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 0.1 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.0 0.0 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.3 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.4 1.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.3 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 56.5 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.1 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.1 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.0 PID ERBB4 PATHWAY ErbB4 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.3 3.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.5 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 56.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.1 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.0 0.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.1 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation