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Results for GCR1

Z-value: 1.58

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Transcription factors associated with GCR1

Gene Symbol Gene ID Gene Info
GCR1
S000005996 Transcriptional activator of genes involved in glycolysis

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GCR1YPL075W0.626.7e-04Click!

Activity profile of GCR1 motif

Sorted Z-values of GCR1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YGR108W 29.10
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YFR055W 18.52
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 17.36 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YDR098C 13.32
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YOL086C 13.08
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YER177W 12.72
BMH1
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YAL038W 12.36
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YCR018C 12.15
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YIL053W 11.95
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YHR174W 11.22
ENO2
Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
YKL152C 11.09
GPM1
Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YLL045C 8.58
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YPL075W 8.52
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YIR021W 8.45
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YJR009C 7.82
TDH2
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YER131W 7.50
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YGR106C 7.10
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YGR040W 6.90
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YHR181W 6.53
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YMR205C 6.50
PFK2
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YKL182W 6.50
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YDR050C 6.45
TPI1
Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
YLR344W 6.44
RPL26A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YKL218C 6.06
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YDR033W 5.99
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YNR054C 5.82
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YGL135W 5.82
RPL1B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YMR143W 5.81
RPS16A
Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YER137C 5.79 Putative protein of unknown function
YJL029C 5.78
VPS53
Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
YMR142C 5.67
RPL13B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YMR106C 5.66
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YGL097W 5.64
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YOL085C 5.57 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YOR315W 5.47
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YAL007C 5.47
ERP2
Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YPL178W 5.42
CBC2
Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YLR198C 5.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
YGR107W 5.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR376W-A 5.27 Putative protein of unknown function; identified by fungal homology and RT-PCR
YKL060C 5.09
FBA1
Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YDR385W 5.07
EFT2
Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YHR173C 5.07 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR455W 5.01 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YBR158W 4.97
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YBR011C 4.85
IPP1
Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YJL200C 4.85
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YGR192C 4.66
TDH3
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YDR044W 4.64
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YHR180W-A 4.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YLR150W 4.52
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YLR257W 4.51 Putative protein of unknown function
YIL114C 4.46
POR2
Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability
YDR497C 4.37
ITR1
Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YHR144C 4.34
DCD1
Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YMR194W 4.29
RPL36A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YIL056W 4.24
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YFR054C 4.15 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR406C 4.12
RPL31B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YKL128C 4.11
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YGL123W 4.09
RPS2
Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YGL123C-A 4.05 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YJL173C 4.02
RFA3
Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YDR339C 4.00
FCF1
Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis; contains a PINc domain; copurifies with Faf1p
YDR074W 3.97
TPS2
Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YHR005C-A 3.97
MRS11
Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YOR375C 3.96
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YDL211C 3.95 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YDL055C 3.94
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YDR133C 3.93 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YBR181C 3.89
RPS6B
Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YGL039W 3.86 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YCR012W 3.81
PGK1
3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YNR001W-A 3.81 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YJR010W 3.75
MET3
ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YKL119C 3.73
VPH2
Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
YOR342C 3.71 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YMR123W 3.69
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YGR027C 3.68
RPS25A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YOR153W 3.61
PDR5
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YPL090C 3.60
RPS6A
Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YDL241W 3.55 Putative protein of unknown function; YDL241W is not an essential gene
YLR154C 3.54
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YLR353W 3.51
BUD8
Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
YDR025W 3.49
RPS11A
Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YKR075C 3.48 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YPR043W 3.47
RPL43A
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype
YEL020C-B 3.46 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YKL122C 3.46
SRP21
Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YER043C 3.45
SAH1
S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YEL027W 3.44
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YER124C 3.42
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YGL148W 3.37
ARO2
Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YER117W 3.33
RPL23B
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YER180C-A 3.33
SLO1
Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
YBR084C-A 3.28
RPL19A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YMR318C 3.26
ADH6
NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YLR372W 3.25
SUR4
Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YCR031C 3.17
RPS14A
Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YLR333C 3.12
RPS25B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YGR090W 3.10
UTP22
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YKL118W 3.10 Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
YJL198W 3.10
PHO90
Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YOL104C 3.10
NDJ1
Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes
YDR384C 3.08
ATO3
Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YEL056W 3.06
HAT2
Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YHR208W 3.05
BAT1
Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
YEL054C 3.03
RPL12A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YDR471W 3.02
RPL27B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
YOR008C-A 3.00 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YHL028W 2.98
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YOL101C 2.98
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YEL029C 2.95
BUD16
Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YKR079C 2.92
TRZ1
tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2
YCL021W-A 2.90 Putative protein of unknown function
YLR328W 2.87
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YIL021W 2.85
RPB3
RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
YNL111C 2.84
CYB5
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YBR191W 2.79
RPL21A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein
YDR382W 2.73
RPP2B
Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YDR517W 2.71
GRH1
Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
YMR217W 2.68
GUA1
GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YKL063C 2.67 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YPR010C 2.67
RPA135
RNA polymerase I subunit A135
YJL188C 2.65
BUD19
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YLR413W 2.63 Putative protein of unknown function; YLR413W is not an essential gene
YPR060C 2.61
ARO7
Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
YJR043C 2.61
POL32
Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YLR264W 2.60
RPS28B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein
YOR230W 2.57
WTM1
Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
YGL209W 2.56
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YKL127W 2.52
PGM1
Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YAR020C 2.51
PAU7
Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
YDR002W 2.50
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YLR367W 2.50
RPS22B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YGR138C 2.49
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YGL040C 2.48
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YBR210W 2.47
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YGL189C 2.44
RPS26A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein
YBL087C 2.44
RPL23A
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
YDL023C 2.44 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YOL136C 2.42
PFK27
6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YFR009W 2.40
GCN20
Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
YER130C 2.38 Hypothetical protein
YMR009W 2.37
ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YCL022C 2.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W
YER083C 2.35
GET2
Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function
YLR043C 2.34
TRX1
Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance
YKL117W 2.33
SBA1
Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
YJL028W 2.33 Protein of unknown function; may interact with ribosomes, based on co-purification experiments
YKR094C 2.33
RPL40B
Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YDR037W 2.31
KRS1
Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YOL127W 2.29
RPL25
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YDL191W 2.26
RPL35A
Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YPL141C 2.26 Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YNL289W 2.26
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YOR314W 2.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL069C 2.26
RPL16B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YDL007W 2.25
RPT2
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YPL245W 2.22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YJL177W 2.21
RPL17B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
YDR279W 2.19
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YOR313C 2.17
SPS4
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YLR154W-B 2.16 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGR164W 2.15 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR099C 2.15 Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
YMR102C 2.15 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YOL161C 2.14
PAU20
Hypothetical protein
YOL124C 2.14
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YOL103W 2.13
ITR2
Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YBR012C 2.12 Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YDR345C 2.11
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YER012W 2.11
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YBR087W 2.10
RFC5
Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YLL064C 2.10
PAU18
Hypothetical protein
YKR038C 2.08
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YDL022W 2.07
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YCR019W 2.07
MAK32
Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YLR411W 2.06
CTR3
High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YNR016C 2.06
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YBR085W 2.06
AAC3
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YGR140W 2.04
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YDR502C 2.03
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YOR310C 2.03
NOP58
Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YGR251W 2.01 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YBL070C 2.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL196C 1.99
ELO1
Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
YLR154W-A 1.99 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YHR013C 1.99
ARD1
Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YKL189W 1.98
HYM1
Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
YGR014W 1.97
MSB2
Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
YLR437C 1.96 Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YLR449W 1.95
FPR4
Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YMR038C 1.90
CCS1
Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation
YOR163W 1.90
DDP1
Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases
YLR227C 1.87
ADY4
Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
YGR139W 1.87 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR074C 1.86
TKL1
Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YAL003W 1.86
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YMR049C 1.86
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1

Network of associatons between targets according to the STRING database.

First level regulatory network of GCR1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
4.7 14.2 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
4.0 12.0 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
3.8 26.9 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
2.9 8.8 GO:0072363 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
2.7 67.0 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
1.9 7.4 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
1.8 12.7 GO:1902707 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
1.7 5.1 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
1.7 5.1 GO:0045901 positive regulation of translational elongation(GO:0045901)
1.6 4.7 GO:0009176 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
1.4 5.7 GO:0030497 fatty acid elongation(GO:0030497)
1.4 24.9 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
1.4 6.9 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
1.3 9.4 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
1.3 3.9 GO:0060548 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
1.3 6.4 GO:0046417 chorismate metabolic process(GO:0046417)
1.3 3.8 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
1.2 8.3 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
1.1 4.6 GO:0000296 spermine transport(GO:0000296)
1.1 5.7 GO:0007535 donor selection(GO:0007535)
1.0 8.4 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
1.0 14.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
1.0 5.1 GO:0006177 GMP biosynthetic process(GO:0006177)
1.0 3.9 GO:1900436 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.9 1.9 GO:0009166 nucleotide catabolic process(GO:0009166)
0.9 2.8 GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422)
0.9 6.4 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.9 5.4 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.9 3.6 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.9 0.9 GO:0009221 pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate biosynthetic process(GO:0046385)
0.9 3.5 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.8 109.8 GO:0002181 cytoplasmic translation(GO:0002181)
0.8 3.4 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.8 5.8 GO:0015791 polyol transport(GO:0015791)
0.8 5.0 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.8 3.3 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.8 6.6 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.8 1.6 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.8 3.1 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.8 3.8 GO:0044070 regulation of anion transport(GO:0044070)
0.7 2.2 GO:0043171 peptide catabolic process(GO:0043171)
0.7 1.5 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.7 5.8 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.7 1.4 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.7 2.8 GO:0031057 negative regulation of histone modification(GO:0031057)
0.7 2.7 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.7 2.7 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.7 7.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.6 7.1 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.6 3.0 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.6 5.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.6 3.5 GO:0006116 NADH oxidation(GO:0006116)
0.6 0.6 GO:0046031 purine nucleoside diphosphate metabolic process(GO:0009135) purine ribonucleoside diphosphate metabolic process(GO:0009179) ribonucleoside diphosphate metabolic process(GO:0009185) ADP metabolic process(GO:0046031)
0.6 3.3 GO:0007030 Golgi organization(GO:0007030)
0.5 2.1 GO:0015680 intracellular copper ion transport(GO:0015680)
0.5 2.7 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.5 0.5 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.5 1.0 GO:0070814 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.5 1.6 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.5 2.1 GO:0015886 heme transport(GO:0015886)
0.5 1.5 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.5 2.0 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.5 4.8 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.5 2.3 GO:0009098 leucine biosynthetic process(GO:0009098)
0.5 10.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.4 1.3 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.4 3.5 GO:0006814 sodium ion transport(GO:0006814)
0.4 1.8 GO:0051046 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.4 0.4 GO:0071482 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.4 0.8 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.4 5.3 GO:0007120 axial cellular bud site selection(GO:0007120)
0.4 0.4 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.4 1.6 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.4 1.2 GO:0015867 ATP transport(GO:0015867)
0.4 0.8 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.4 1.6 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.4 1.1 GO:0043902 positive regulation of multi-organism process(GO:0043902)
0.4 1.5 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.4 1.8 GO:0045337 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.4 1.1 GO:0008272 sulfate transport(GO:0008272)
0.4 1.8 GO:0051125 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) regulation of actin nucleation(GO:0051125)
0.4 5.8 GO:0006448 regulation of translational elongation(GO:0006448)
0.4 5.0 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.4 0.7 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.3 4.9 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.3 1.7 GO:0007232 osmosensory signaling pathway via Sho1 osmosensor(GO:0007232)
0.3 1.0 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.3 0.9 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.3 1.5 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.3 0.3 GO:0000967 rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.3 4.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.3 2.6 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.3 5.1 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.3 7.0 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.3 7.1 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.3 0.8 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.3 3.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.3 2.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.3 2.6 GO:0006272 leading strand elongation(GO:0006272)
0.3 2.0 GO:0000022 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.3 1.0 GO:0097549 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
0.3 0.5 GO:0071902 positive regulation of protein serine/threonine kinase activity(GO:0071902)
0.2 1.0 GO:0042173 regulation of sporulation resulting in formation of a cellular spore(GO:0042173)
0.2 0.7 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.2 0.5 GO:0018344 protein geranylgeranylation(GO:0018344)
0.2 0.5 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.2 1.7 GO:0032988 ribonucleoprotein complex disassembly(GO:0032988)
0.2 1.0 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.2 1.4 GO:0032273 positive regulation of protein polymerization(GO:0032273)
0.2 4.2 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.2 3.3 GO:0030488 tRNA methylation(GO:0030488)
0.2 1.4 GO:0030042 actin filament depolymerization(GO:0030042)
0.2 1.2 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.2 1.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 1.1 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.2 0.4 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.2 0.2 GO:0045896 regulation of transcription during mitosis(GO:0045896)
0.2 0.7 GO:0006068 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
0.2 0.9 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.2 1.5 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.2 0.4 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.2 8.0 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.2 1.0 GO:0042558 folic acid-containing compound metabolic process(GO:0006760) folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound metabolic process(GO:0042558) pteridine-containing compound biosynthetic process(GO:0042559)
0.2 5.9 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.2 1.5 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.2 1.1 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.2 1.3 GO:0016559 peroxisome fission(GO:0016559)
0.2 0.5 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.2 5.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2 0.5 GO:0000916 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.2 1.4 GO:0052803 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.2 4.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 10.0 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.2 2.2 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.2 0.5 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.2 6.0 GO:0006612 protein targeting to membrane(GO:0006612)
0.2 0.8 GO:0043007 maintenance of rDNA(GO:0043007)
0.2 0.6 GO:0042990 regulation of transcription factor import into nucleus(GO:0042990)
0.2 0.8 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.2 0.2 GO:0048211 Golgi vesicle docking(GO:0048211)
0.2 0.6 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
0.2 0.8 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 0.6 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.1 1.6 GO:0006415 translational termination(GO:0006415)
0.1 1.2 GO:0006857 oligopeptide transport(GO:0006857)
0.1 1.7 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 0.4 GO:0006458 'de novo' protein folding(GO:0006458)
0.1 0.8 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.1 1.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 1.2 GO:0009435 NAD biosynthetic process(GO:0009435)
0.1 0.1 GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing(GO:0071031)
0.1 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.1 14.8 GO:0006364 rRNA processing(GO:0006364)
0.1 0.7 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.1 1.1 GO:0006379 mRNA cleavage(GO:0006379)
0.1 0.5 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.1 0.8 GO:0033313 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.1 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 4.4 GO:0006400 tRNA modification(GO:0006400)
0.1 0.5 GO:2000221 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.1 0.4 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.1 1.9 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 0.2 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.1 1.1 GO:0017148 negative regulation of translation(GO:0017148)
0.1 1.9 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 1.3 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 0.2 GO:0043244 regulation of protein complex disassembly(GO:0043244)
0.1 0.6 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 0.7 GO:0006783 porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole biosynthetic process(GO:0033014)
0.1 0.2 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.6 GO:0035376 sterol import(GO:0035376)
0.1 0.4 GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.1 1.7 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.3 GO:0006999 nuclear pore organization(GO:0006999)
0.1 0.2 GO:0010695 regulation of spindle pole body separation(GO:0010695)
0.1 2.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.1 3.0 GO:0006333 chromatin assembly or disassembly(GO:0006333)
0.1 0.2 GO:1901983 regulation of histone acetylation(GO:0035065) regulation of protein acetylation(GO:1901983) regulation of peptidyl-lysine acetylation(GO:2000756)
0.1 0.8 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.3 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 0.3 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 2.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.7 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) isoleucine biosynthetic process(GO:0009097)
0.1 0.4 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.5 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.6 GO:0010529 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.1 0.9 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 1.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 1.2 GO:0006513 protein monoubiquitination(GO:0006513)
0.1 0.2 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.1 0.4 GO:0043487 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.1 0.7 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.8 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.5 GO:0006012 galactose metabolic process(GO:0006012)
0.1 0.7 GO:0010383 cell wall polysaccharide metabolic process(GO:0010383)
0.1 0.4 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.1 0.4 GO:0007009 plasma membrane organization(GO:0007009)
0.1 0.3 GO:0045116 protein neddylation(GO:0045116)
0.1 0.3 GO:0060304 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.3 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1 0.1 GO:0032231 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233)
0.1 0.1 GO:0070507 regulation of microtubule-based process(GO:0032886) regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.2 GO:0072337 modified amino acid transport(GO:0072337)
0.0 0.0 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.0 0.2 GO:0031385 regulation of termination of mating projection growth(GO:0031385)
0.0 0.4 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.1 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072) negative regulation of phospholipid metabolic process(GO:1903726)
0.0 0.4 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.0 0.2 GO:0015883 FAD transport(GO:0015883)
0.0 0.2 GO:0042435 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.1 GO:0000101 sulfur amino acid transport(GO:0000101)
0.0 0.1 GO:0034032 coenzyme A metabolic process(GO:0015936) nucleoside bisphosphate metabolic process(GO:0033865) ribonucleoside bisphosphate metabolic process(GO:0033875) purine nucleoside bisphosphate metabolic process(GO:0034032)
0.0 0.2 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.0 0.2 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.0 0.4 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 1.1 GO:0043547 regulation of GTPase activity(GO:0043087) positive regulation of GTPase activity(GO:0043547)
0.0 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.2 GO:0006817 phosphate ion transport(GO:0006817)
0.0 0.1 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:1905038 negative regulation of lipid biosynthetic process(GO:0051055) regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.0 0.5 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0 0.3 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.0 0.3 GO:0048193 Golgi vesicle transport(GO:0048193)
0.0 0.3 GO:0044774 mitotic DNA integrity checkpoint(GO:0044774)
0.0 0.7 GO:0036503 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0 0.3 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.1 GO:0032042 mitochondrial DNA metabolic process(GO:0032042)
0.0 0.0 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.3 GO:0010833 telomere maintenance via telomere lengthening(GO:0010833)
0.0 0.1 GO:0006688 glycosphingolipid metabolic process(GO:0006687) glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.1 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0070583 spore membrane bending pathway(GO:0070583)
0.0 0.3 GO:0006414 translational elongation(GO:0006414)
0.0 0.3 GO:0000001 mitochondrion inheritance(GO:0000001) mitochondrion distribution(GO:0048311)
0.0 0.1 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.0 0.1 GO:0019363 nicotinamide nucleotide biosynthetic process(GO:0019359) pyridine nucleotide biosynthetic process(GO:0019363)
0.0 0.4 GO:0006505 GPI anchor metabolic process(GO:0006505)
0.0 0.3 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 0.2 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.0 0.1 GO:0030473 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.0 0.1 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.0 GO:0015865 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.0 0.1 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.1 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.6 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.1 GO:0031938 regulation of chromatin silencing at telomere(GO:0031938)
0.0 0.0 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.9 5.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.8 30.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.4 5.8 GO:0000938 GARP complex(GO:0000938)
1.4 4.3 GO:0005662 DNA replication factor A complex(GO:0005662)
1.2 6.2 GO:0034518 RNA cap binding complex(GO:0034518)
1.1 3.3 GO:0046930 pore complex(GO:0046930)
1.1 3.3 GO:0070545 PeBoW complex(GO:0070545)
1.1 4.3 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
1.1 8.5 GO:0042597 periplasmic space(GO:0042597)
1.0 85.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.9 2.7 GO:0043529 GET complex(GO:0043529)
0.9 2.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.9 52.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.8 5.0 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.8 2.4 GO:0031415 NatA complex(GO:0031415)
0.8 3.9 GO:0032545 CURI complex(GO:0032545)
0.7 5.7 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.7 2.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.7 3.4 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.7 2.7 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.6 4.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.6 16.9 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.5 19.7 GO:0005811 lipid particle(GO:0005811)
0.5 1.5 GO:0016363 nuclear matrix(GO:0016363)
0.5 6.6 GO:0022626 cytosolic ribosome(GO:0022626)
0.5 2.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 1.3 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.4 2.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.4 3.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.4 1.7 GO:0031518 CBF3 complex(GO:0031518)
0.4 2.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.4 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 4.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 1.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.4 2.5 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.4 2.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.3 2.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.3 4.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.3 2.2 GO:0000346 transcription export complex(GO:0000346)
0.3 1.2 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.3 0.9 GO:0097344 Rix1 complex(GO:0097344)
0.3 0.3 GO:0030689 Noc complex(GO:0030689)
0.3 0.8 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3 1.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.3 1.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 1.6 GO:0031499 TRAMP complex(GO:0031499)
0.3 1.3 GO:0030478 actin cap(GO:0030478)
0.2 0.5 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.2 1.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 3.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 1.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.2 1.3 GO:0016272 prefoldin complex(GO:0016272)
0.2 2.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.2 1.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 2.0 GO:0000243 commitment complex(GO:0000243)
0.2 0.2 GO:0034099 luminal surveillance complex(GO:0034099)
0.2 1.3 GO:0042555 MCM complex(GO:0042555)
0.2 0.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 3.2 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.2 0.6 GO:0042788 polysomal ribosome(GO:0042788)
0.2 5.5 GO:0030686 90S preribosome(GO:0030686)
0.2 5.6 GO:0032040 small-subunit processome(GO:0032040)
0.2 0.7 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.2 0.5 GO:0005955 calcineurin complex(GO:0005955)
0.2 0.7 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.2 1.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 1.0 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 0.9 GO:0000136 alpha-1,6-mannosyltransferase complex(GO:0000136)
0.2 1.2 GO:0017119 Golgi transport complex(GO:0017119)
0.2 2.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 4.9 GO:0044445 cytosolic part(GO:0044445)
0.1 1.0 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.1 5.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 0.3 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.4 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.1 0.8 GO:0001400 mating projection base(GO:0001400)
0.1 0.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.4 GO:0000930 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.1 0.7 GO:0000796 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.1 5.5 GO:0000131 incipient cellular bud site(GO:0000131)
0.1 0.5 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 0.6 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.3 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 0.3 GO:0042729 DASH complex(GO:0042729)
0.1 0.5 GO:0005884 actin filament(GO:0005884)
0.1 0.6 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.6 GO:0051233 spindle midzone(GO:0051233)
0.1 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.3 GO:0000814 ESCRT II complex(GO:0000814)
0.1 0.4 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.1 2.9 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.1 0.4 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.7 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 1.2 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.5 GO:0031201 SNARE complex(GO:0031201)
0.1 11.1 GO:0005933 cellular bud(GO:0005933)
0.1 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.3 GO:0034044 exomer complex(GO:0034044)
0.1 0.3 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.7 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.4 GO:0034399 nuclear periphery(GO:0034399)
0.1 0.6 GO:0005688 U6 snRNP(GO:0005688)
0.1 9.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 2.7 GO:0030427 site of polarized growth(GO:0030427)
0.1 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 8.5 GO:0005730 nucleolus(GO:0005730)
0.1 0.4 GO:0000439 core TFIIH complex(GO:0000439)
0.1 1.0 GO:0016586 RSC complex(GO:0016586)
0.1 0.3 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.4 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.1 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.0 4.1 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.0 1.2 GO:0005794 Golgi apparatus(GO:0005794)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 2.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.6 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.1 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 8.1 GO:0005886 plasma membrane(GO:0005886)
0.0 0.2 GO:0034967 Set3 complex(GO:0034967)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.8 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.3 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.0 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.8 GO:0005815 microtubule organizing center(GO:0005815) spindle pole body(GO:0005816)
0.0 3.0 GO:0005829 cytosol(GO:0005829)
0.0 0.3 GO:0030863 cortical cytoskeleton(GO:0030863) cortical actin cytoskeleton(GO:0030864)
0.0 0.2 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.2 GO:0005844 polysome(GO:0005844)
0.0 0.0 GO:0000798 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.0 GO:0005801 cis-Golgi network(GO:0005801)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.7 GO:0051219 phosphoprotein binding(GO:0051219)
4.2 12.5 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
4.0 11.9 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
3.8 11.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
2.6 7.9 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
2.1 6.3 GO:0000339 RNA cap binding(GO:0000339)
2.0 11.9 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.9 5.7 GO:0009922 fatty acid elongase activity(GO:0009922)
1.8 8.9 GO:0008443 phosphofructokinase activity(GO:0008443)
1.7 8.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.6 6.5 GO:0016417 S-acyltransferase activity(GO:0016417)
1.5 6.1 GO:0016841 ammonia-lyase activity(GO:0016841) racemase and epimerase activity(GO:0016854)
1.5 5.9 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.4 5.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.4 7.1 GO:0004707 MAP kinase activity(GO:0004707)
1.3 4.0 GO:0004805 trehalose-phosphatase activity(GO:0004805)
1.3 3.9 GO:0070568 guanylyltransferase activity(GO:0070568)
1.3 5.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
1.2 3.6 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
1.2 27.6 GO:0019901 protein kinase binding(GO:0019901)
1.2 4.6 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
1.1 6.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.1 4.6 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
1.1 3.4 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
1.1 3.3 GO:0008308 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
1.0 3.1 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
1.0 8.0 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
1.0 3.8 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.9 13.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.8 2.5 GO:0016504 peptidase activator activity(GO:0016504)
0.8 2.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.7 2.9 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.7 4.3 GO:0008312 7S RNA binding(GO:0008312)
0.7 2.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.7 2.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.7 2.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.7 2.1 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.7 135.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 3.9 GO:0003993 acid phosphatase activity(GO:0003993)
0.7 2.6 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.6 2.5 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.6 3.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.6 13.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.6 2.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.5 4.9 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.5 5.4 GO:0019239 deaminase activity(GO:0019239)
0.5 3.3 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295)
0.5 1.6 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.5 2.1 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.5 7.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.5 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.5 2.0 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.5 7.9 GO:0042803 protein homodimerization activity(GO:0042803)
0.5 1.9 GO:0005034 osmosensor activity(GO:0005034)
0.5 1.9 GO:0016531 copper chaperone activity(GO:0016531)
0.5 1.4 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.4 6.1 GO:0001671 ATPase activator activity(GO:0001671)
0.4 2.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.4 1.7 GO:0008172 S-methyltransferase activity(GO:0008172)
0.4 0.4 GO:0019842 vitamin binding(GO:0019842)
0.4 5.8 GO:0070566 adenylyltransferase activity(GO:0070566)
0.4 2.8 GO:0005216 ion channel activity(GO:0005216)
0.4 0.8 GO:1901681 sulfur compound binding(GO:1901681)
0.4 1.5 GO:0001055 RNA polymerase II activity(GO:0001055)
0.4 2.2 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.4 0.4 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.4 1.8 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.4 1.1 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.4 1.1 GO:0072341 modified amino acid binding(GO:0072341)
0.4 2.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 2.1 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.3 1.7 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.3 4.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.3 1.3 GO:0019206 nucleoside kinase activity(GO:0019206)
0.3 1.3 GO:0009378 four-way junction helicase activity(GO:0009378)
0.3 0.9 GO:0016882 cyclo-ligase activity(GO:0016882)
0.3 1.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.3 4.5 GO:0016866 intramolecular transferase activity(GO:0016866)
0.3 1.5 GO:0019201 nucleotide kinase activity(GO:0019201)
0.3 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 2.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.3 1.1 GO:0008144 drug binding(GO:0008144)
0.3 8.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.3 1.0 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.3 1.3 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.2 1.6 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 1.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.2 1.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 1.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 1.1 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 1.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 2.8 GO:0051015 actin filament binding(GO:0051015)
0.2 0.6 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2 2.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 1.0 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.2 0.8 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.2 6.8 GO:0030674 protein binding, bridging(GO:0030674)
0.2 8.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.2 2.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 1.2 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.2 0.6 GO:0001169 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
0.2 0.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.2 2.3 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.2 2.0 GO:0043495 protein anchor(GO:0043495)
0.2 0.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 2.4 GO:0051087 chaperone binding(GO:0051087)
0.2 0.5 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.2 5.9 GO:0000287 magnesium ion binding(GO:0000287)
0.2 0.5 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.2 0.7 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.2 0.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 1.6 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 3.5 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.2 2.7 GO:0005048 signal sequence binding(GO:0005048)
0.2 0.8 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.2 0.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.4 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.1 0.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 2.1 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 3.6 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 1.2 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.1 0.1 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.1 0.7 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.4 GO:0070717 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.1 2.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.1 0.9 GO:0031386 protein tag(GO:0031386)
0.1 0.4 GO:0004100 chitin synthase activity(GO:0004100)
0.1 3.6 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.8 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 6.8 GO:0003924 GTPase activity(GO:0003924)
0.1 3.1 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 5.2 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.6 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 1.0 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 1.1 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 0.3 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.4 GO:0003779 actin binding(GO:0003779)
0.1 0.8 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.1 0.6 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.1 0.1 GO:0001186 transcription factor activity, RNA polymerase I transcription factor recruiting(GO:0001186)
0.1 2.7 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 0.5 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 6.0 GO:0016791 phosphatase activity(GO:0016791)
0.1 0.1 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.3 GO:0016642 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.1 0.6 GO:0017069 snRNA binding(GO:0017069)
0.1 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 0.4 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.1 0.1 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 1.8 GO:0015631 tubulin binding(GO:0015631)
0.1 1.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.3 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.1 0.5 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
0.1 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.5 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.2 GO:0048038 quinone binding(GO:0048038)
0.0 0.4 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.0 0.5 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0043022 ribosome binding(GO:0043022)
0.0 0.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0030276 clathrin binding(GO:0030276)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.2 GO:0001004 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.3 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.3 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.0 0.1 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.3 GO:0019843 rRNA binding(GO:0019843)
0.0 0.2 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.0 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.0 0.1 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.1 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.1 GO:0016408 C-acyltransferase activity(GO:0016408)
0.0 0.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.4 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.2 GO:0050661 NADP binding(GO:0050661)
0.0 0.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.1 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.4 1.3 PID CDC42 PATHWAY CDC42 signaling events
0.4 3.6 PID ATR PATHWAY ATR signaling pathway
0.2 1.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 0.9 PID PLK1 PATHWAY PLK1 signaling events
0.1 0.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 0.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.2 PID E2F PATHWAY E2F transcription factor network
0.1 0.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.1 PID ATM PATHWAY ATM pathway
0.0 0.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 21.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.6 4.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.8 2.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.8 2.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.7 17.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.5 2.1 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.5 2.1 REACTOME TRANSCRIPTION COUPLED NER TC NER Genes involved in Transcription-coupled NER (TC-NER)
0.5 2.1 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.4 1.2 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.3 1.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.3 1.7 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.3 0.5 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.3 1.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 1.0 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.2 1.7 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 1.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 0.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 0.4 REACTOME DNA STRAND ELONGATION Genes involved in DNA strand elongation
0.2 0.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 0.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 0.5 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.1 0.4 REACTOME SIGNALLING BY NGF Genes involved in Signalling by NGF
0.1 1.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.2 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.1 0.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.0 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.1 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway