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Results for GIS1

Z-value: 2.69

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Transcription factors associated with GIS1

Gene Symbol Gene ID Gene Info
GIS1
S000002503 Histone demethylase and transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GIS1YDR096W0.935.1e-12Click!

Activity profile of GIS1 motif

Sorted Z-values of GIS1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YMR175W 80.93
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YHR139C 59.93
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YMR107W 55.03
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YGR087C 54.44
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YNR034W-A 51.51 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YBR072W 48.66
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YOL052C-A 46.76
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YOR393W 46.55
ERR1
Protein of unknown function, has similarity to enolases
YKL217W 43.66
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YPL223C 41.15
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YHR096C 38.15
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YNL117W 36.82
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YER065C 36.32
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YNL194C 34.45 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YMR174C 33.60
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YIL136W 33.10
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YGR088W 31.57
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YOL084W 31.27
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YPR026W 30.77
ATH1
Acid trehalase required for utilization of extracellular trehalose
YOR348C 30.66
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YOR391C 30.50
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YIL099W 29.87
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YMR081C 29.69
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YEL039C 29.54
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YFR017C 29.27 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YGR243W 29.11
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR105C 28.43
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YAL054C 27.75
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YFR053C 27.59
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YDR277C 27.33
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YMR206W 27.23 Putative protein of unknown function; YMR206W is not an essential gene
YHL040C 26.03
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YPL054W 25.74
LEE1
Zinc-finger protein of unknown function
YDR343C 25.58
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YDL218W 25.41 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YPR010C-A 25.25 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YPL186C 24.59
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YPL036W 24.58
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YBL015W 23.81
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YIL057C 23.67 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YIL101C 23.09
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YLR312C 22.86
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YPL230W 22.84
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YKL026C 22.68
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YGR236C 22.58
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR043C 22.50
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YCR021C 22.05
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YGR067C 21.94 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YPL185W 21.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YAL034C 21.75
FUN19
Non-essential protein of unknown function
YAL062W 21.69
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YDR070C 21.51
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR171W 21.20
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YDR258C 21.05
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YGR201C 20.72 Putative protein of unknown function
YBR241C 20.57 Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YAL061W 20.46
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YEL011W 19.98
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YMR251W 19.62
GTO3
Omega class glutathione transferase; putative cytosolic localization
YML089C 19.43 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YLR149C 19.34 Putative protein of unknown function; YLR149C is not an essential gene
YDR096W 19.12
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YER150W 19.08
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YLR377C 18.95
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YMR169C 18.93
ALD3
Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YPL271W 18.84
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YDL085W 18.80
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YJR115W 18.32 Putative protein of unknown function
YKL163W 18.20
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YHR139C-A 18.05 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR031W 17.73
CRS5
Copper-binding metallothionein, required for wild-type copper resistance
YBL049W 17.58
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YOL085W-A 17.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YPL222W 17.08
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR406W 16.95
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YJL089W 16.95
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YKL065W-A 16.72 Putative protein of unknown function
YOR392W 16.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat
YGR256W 16.01
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YKL107W 15.99 Putative protein of unknown function
YER067W 15.66 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YOR186W 15.56 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YOL082W 15.52
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YER103W 15.43
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YKL103C 15.32
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YBL078C 15.26
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YMR194C-B 14.97 Putative protein of unknown function
YKL148C 14.69
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YBR117C 14.60
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YIR039C 14.59
YPS6
Putative GPI-anchored aspartic protease
YLL026W 14.55
HSP104
Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YPR192W 14.54
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YDL214C 14.12
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YFL030W 13.98
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YCL048W-A 13.97 Putative protein of unknown function
YKL031W 13.94 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YIL100C-A 13.78 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR178C 13.77
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YAR053W 13.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR201C-A 13.66 Putative protein of unknown function
YBR147W 13.55
RTC2
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YDR342C 13.51
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YFL011W 13.33
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YFL058W 13.27
THI5
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YLR178C 13.27
TFS1
Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway
YKL109W 13.24
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YPR036W-A 13.06 Protein of unknown function; transcription is regulated by Pdr1p
YMR118C 12.75 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YGL096W 12.73
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YIL100W 12.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YLR080W 12.66
EMP46
Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YKL102C 12.60 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YNR001C 12.47
CIT1
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YLR327C 12.41
TMA10
Protein of unknown function that associates with ribosomes
YDR119W-A 12.39 Putative protein of unknown function
YDL169C 12.36
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YPL250C 12.34
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YGR070W 12.32
ROM1
GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YDL210W 12.28
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YIL086C 12.22 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML100W 12.22
TSL1
Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YDR043C 12.06
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YDR536W 11.94
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YBL075C 11.93
SSA3
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YOL060C 11.83
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YML090W 11.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YML128C 11.79
MSC1
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YDL222C 11.73
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YDL130W-A 11.67
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YGR248W 11.65
SOL4
6-phosphogluconolactonase with similarity to Sol3p
YNL180C 11.51
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YPL247C 11.49 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; YPL247C is not an essential gene
YNL144C 11.30 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YJL116C 10.99
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YJL067W 10.85 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR250W 10.84
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YLR164W 10.67 Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YNL014W 10.66
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YOR100C 10.66
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YNL179C 10.64 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YHR082C 10.64
KSP1
Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
YOR173W 10.62
DCS2
Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YAR050W 10.60
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YBR214W 10.55
SDS24
One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YHR087W 10.49
RTC3
Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity
YCR005C 10.29
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YCR025C 10.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YJR095W 10.22
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YPL240C 10.17
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YHL021C 10.15
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YMR256C 10.14
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YIL087C 10.09
LRC2
Putative protein of unknown function; protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YOR346W 10.06
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YHR033W 9.99 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YLR346C 9.95 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YAR060C 9.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER084W 9.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR542W 9.82
PAU10
Hypothetical protein
YEL070W 9.63
DSF1
Deletion suppressor of mpt5 mutation
YMR196W 9.61 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
YDR533C 9.60
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YOR343C 9.56 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YEL059W 9.52 Dubious open reading frame unlikely to encode a functional protein
YPL061W 9.46
ALD6
Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YKL093W 9.44
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YER066W 9.39 Putative protein of unknown function; YER066W is not an essential gene
YPR184W 9.39
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YNL305C 9.38 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YOL047C 9.35 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR001C 9.34
NTH1
Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
YGL156W 9.27
AMS1
Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
YJL144W 9.27 Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YML091C 9.27
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YNL077W 9.25
APJ1
Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR195W 9.24
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YOR345C 9.17 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YER039C-A 9.03 Putative protein of unknown function; YER039C-A is not an essential gene
YPL017C 9.00
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YIL045W 8.95
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YHR001W-A 8.88
QCR10
Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YLL041C 8.87
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YKL050C 8.79 Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p
YGL045W 8.72
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YIL155C 8.65
GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YMR013C 8.64
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YGR066C 8.62 Putative protein of unknown function
YHR211W 8.61
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YGR258C 8.61
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YPL119C 8.58
DBP1
Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs
YLL053C 8.53 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YOR120W 8.53
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YDL204W 8.53
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YAR047C 8.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER054C 8.42
GIP2
Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p
YJL066C 8.42
MPM1
Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches
YPR027C 8.40 Putative protein of unknown function
YNL142W 8.39
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YPR127W 8.34 Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YIL122W 8.29
POG1
Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YGL177W 8.28 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Network of associatons between targets according to the STRING database.

First level regulatory network of GIS1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
20.0 79.9 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
19.2 76.7 GO:0006848 pyruvate transport(GO:0006848)
17.6 52.7 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
13.5 40.6 GO:0005993 trehalose catabolic process(GO:0005993)
13.4 53.4 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
13.2 39.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
12.8 38.5 GO:0043335 protein unfolding(GO:0043335)
11.6 34.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
10.6 95.0 GO:0006097 glyoxylate cycle(GO:0006097)
9.6 19.2 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
9.3 46.3 GO:0005980 glycogen catabolic process(GO:0005980)
9.1 27.2 GO:0015755 fructose transport(GO:0015755)
9.0 35.9 GO:0015804 neutral amino acid transport(GO:0015804)
8.9 62.3 GO:0006083 acetate metabolic process(GO:0006083)
7.3 58.6 GO:0015758 glucose transport(GO:0015758)
7.1 7.1 GO:0097306 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
6.4 19.1 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
6.3 31.4 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
6.2 24.8 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
6.1 24.3 GO:0006598 polyamine catabolic process(GO:0006598)
5.8 57.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
5.6 27.9 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
5.5 22.0 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
5.2 21.0 GO:0071467 cellular response to pH(GO:0071467)
5.2 30.9 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
5.1 5.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
4.9 14.7 GO:0006538 glutamate catabolic process(GO:0006538)
4.9 14.6 GO:0006545 glycine biosynthetic process(GO:0006545)
4.6 9.3 GO:0006013 mannose metabolic process(GO:0006013)
4.3 12.8 GO:0042843 D-xylose catabolic process(GO:0042843)
4.3 12.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
4.1 12.4 GO:1903339 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
4.1 12.4 GO:0090630 activation of GTPase activity(GO:0090630)
4.1 61.8 GO:0005978 glycogen biosynthetic process(GO:0005978)
4.1 20.5 GO:0034486 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
3.9 11.7 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
3.9 30.8 GO:0015891 siderophore transport(GO:0015891)
3.8 34.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
3.8 60.1 GO:0006754 ATP biosynthetic process(GO:0006754)
3.5 3.5 GO:0044109 cellular alcohol catabolic process(GO:0044109)
3.5 14.1 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
3.5 10.5 GO:0019676 ammonia assimilation cycle(GO:0019676)
3.5 13.8 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
3.4 17.2 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
3.4 34.3 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
3.4 10.3 GO:0006000 fructose metabolic process(GO:0006000)
3.4 6.7 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
3.3 13.3 GO:0016242 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
3.1 3.1 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
3.1 40.5 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
3.0 6.1 GO:0042732 D-xylose metabolic process(GO:0042732)
2.9 26.3 GO:0046364 monosaccharide biosynthetic process(GO:0046364)
2.8 8.5 GO:0015740 C4-dicarboxylate transport(GO:0015740)
2.7 10.9 GO:0015847 putrescine transport(GO:0015847)
2.6 7.9 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
2.6 10.6 GO:0015793 glycerol transport(GO:0015793)
2.6 2.6 GO:0046185 aldehyde catabolic process(GO:0046185)
2.6 15.7 GO:0006537 glutamate biosynthetic process(GO:0006537)
2.6 2.6 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
2.4 7.3 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
2.4 7.3 GO:0006108 malate metabolic process(GO:0006108)
2.4 57.0 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
2.4 2.4 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
2.3 7.0 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
2.3 6.9 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
2.3 20.6 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
2.3 4.5 GO:0072353 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
2.2 38.0 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
2.2 6.6 GO:0019748 secondary metabolic process(GO:0019748)
2.1 8.2 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
2.0 15.7 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
2.0 5.9 GO:0046058 cAMP metabolic process(GO:0046058)
1.9 5.8 GO:0042128 nitrate metabolic process(GO:0042126) nitrate assimilation(GO:0042128)
1.9 5.7 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
1.9 5.7 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.9 9.3 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
1.8 8.8 GO:0043954 cellular component maintenance(GO:0043954)
1.7 8.6 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
1.7 8.5 GO:0019433 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
1.7 71.5 GO:0070590 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
1.7 5.1 GO:0033499 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
1.7 15.2 GO:0006119 oxidative phosphorylation(GO:0006119)
1.7 6.7 GO:0005977 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
1.7 28.2 GO:0006749 glutathione metabolic process(GO:0006749)
1.7 1.7 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
1.6 3.3 GO:0000821 regulation of arginine metabolic process(GO:0000821)
1.6 25.9 GO:0001101 response to acid chemical(GO:0001101)
1.6 21.9 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
1.5 6.2 GO:0034389 lipid particle organization(GO:0034389)
1.5 9.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
1.5 3.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.5 1.5 GO:0000304 response to singlet oxygen(GO:0000304)
1.5 9.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
1.5 9.0 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
1.5 7.4 GO:0043605 cellular amide catabolic process(GO:0043605)
1.4 43.7 GO:0006200 obsolete ATP catabolic process(GO:0006200)
1.3 27.4 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
1.3 15.4 GO:0019740 nitrogen utilization(GO:0019740)
1.3 11.4 GO:0070987 error-free translesion synthesis(GO:0070987)
1.3 15.1 GO:0016925 protein sumoylation(GO:0016925)
1.3 8.8 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
1.2 4.9 GO:0006527 arginine catabolic process(GO:0006527)
1.2 3.6 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
1.2 10.8 GO:0046686 response to cadmium ion(GO:0046686)
1.2 4.8 GO:0051654 establishment of mitochondrion localization(GO:0051654)
1.1 7.9 GO:0007130 synaptonemal complex assembly(GO:0007130)
1.1 3.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
1.1 4.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
1.1 10.6 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
1.1 5.3 GO:0016562 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
1.0 3.1 GO:0015976 carbon utilization(GO:0015976)
1.0 5.1 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
1.0 41.1 GO:0009060 aerobic respiration(GO:0009060)
1.0 3.0 GO:0032079 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
1.0 4.9 GO:0000023 maltose metabolic process(GO:0000023)
1.0 2.0 GO:0000411 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.9 2.8 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.9 2.8 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.9 2.7 GO:0015888 thiamine transport(GO:0015888)
0.9 2.7 GO:0036257 multivesicular body organization(GO:0036257)
0.9 4.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.9 6.9 GO:0072348 sulfur compound transport(GO:0072348)
0.9 6.0 GO:0010508 positive regulation of autophagy(GO:0010508)
0.9 6.9 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.9 2.6 GO:0015809 arginine transport(GO:0015809)
0.8 1.7 GO:0045117 azole transport(GO:0045117)
0.8 2.5 GO:0071168 protein localization to chromatin(GO:0071168)
0.8 1.6 GO:0043270 positive regulation of ion transport(GO:0043270)
0.8 3.2 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.8 15.8 GO:0098656 anion transmembrane transport(GO:0098656)
0.8 3.1 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.8 1.5 GO:0009268 response to pH(GO:0009268)
0.7 3.0 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.7 8.1 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.7 2.9 GO:0046503 glycerolipid catabolic process(GO:0046503)
0.7 2.9 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.7 3.6 GO:0009757 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.7 2.9 GO:0051503 adenine nucleotide transport(GO:0051503)
0.7 4.2 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.7 0.7 GO:0015688 iron chelate transport(GO:0015688)
0.7 4.2 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.7 6.0 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.7 2.0 GO:0000755 cytogamy(GO:0000755)
0.6 3.8 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.6 13.3 GO:0031503 protein complex localization(GO:0031503)
0.6 13.8 GO:0022900 electron transport chain(GO:0022900)
0.6 2.3 GO:0051260 protein homooligomerization(GO:0051260)
0.6 4.0 GO:0018345 protein palmitoylation(GO:0018345)
0.6 3.4 GO:0006452 translational frameshifting(GO:0006452)
0.6 2.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.5 26.6 GO:0007031 peroxisome organization(GO:0007031)
0.5 10.4 GO:0016579 protein deubiquitination(GO:0016579)
0.5 1.5 GO:0033313 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.5 1.0 GO:0051093 negative regulation of cell differentiation(GO:0045596) negative regulation of developmental process(GO:0051093)
0.5 3.5 GO:0006635 fatty acid beta-oxidation(GO:0006635) fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.5 2.5 GO:0006265 DNA topological change(GO:0006265)
0.5 2.0 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.5 1.4 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.5 0.5 GO:0051446 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.5 3.3 GO:0009306 protein secretion(GO:0009306)
0.5 2.8 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.5 1.4 GO:0006638 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.5 0.9 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.5 19.6 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.5 1.4 GO:0042407 cristae formation(GO:0042407)
0.4 7.6 GO:0006895 Golgi to endosome transport(GO:0006895)
0.4 0.4 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.4 1.8 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.4 1.3 GO:1901701 cellular response to oxygen-containing compound(GO:1901701)
0.4 0.4 GO:0035376 sterol import(GO:0035376)
0.4 3.0 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.4 1.6 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.4 1.2 GO:0097033 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.4 2.4 GO:0006465 signal peptide processing(GO:0006465)
0.4 0.4 GO:0070726 cell wall assembly(GO:0070726)
0.4 3.9 GO:0006312 mitotic recombination(GO:0006312)
0.4 1.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.4 1.5 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.4 1.5 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.4 0.8 GO:0001304 progressive alteration of chromatin involved in replicative cell aging(GO:0001304) negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.4 2.6 GO:0055074 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.4 4.8 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.4 1.1 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.4 1.1 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.4 3.2 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.4 8.9 GO:0000902 cell morphogenesis(GO:0000902)
0.3 3.0 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.3 0.6 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.3 4.8 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.3 0.6 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.3 3.7 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.3 2.7 GO:0051294 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.3 0.6 GO:0006089 lactate metabolic process(GO:0006089)
0.3 0.3 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.3 0.9 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.3 0.9 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.3 4.2 GO:0000209 protein polyubiquitination(GO:0000209)
0.3 1.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.3 2.2 GO:0009263 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 1.1 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.3 3.7 GO:0007266 Rho protein signal transduction(GO:0007266)
0.3 0.5 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.3 1.0 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.3 8.5 GO:0048468 ascospore formation(GO:0030437) cell development(GO:0048468)
0.3 1.0 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835) negative regulation of meiotic cell cycle(GO:0051447)
0.2 0.7 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.2 0.5 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.2 1.9 GO:0015893 drug transport(GO:0015893)
0.2 0.9 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.2 1.3 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.2 1.3 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.2 2.0 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.2 0.7 GO:0090399 replicative senescence(GO:0090399)
0.2 3.0 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.2 0.6 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 0.9 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.2 0.7 GO:0043388 positive regulation of DNA binding(GO:0043388) positive regulation of binding(GO:0051099) regulation of DNA binding(GO:0051101)
0.2 0.3 GO:0018410 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.2 0.7 GO:0006813 potassium ion transport(GO:0006813)
0.2 0.5 GO:0001109 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.2 0.3 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 0.2 GO:0035822 gene conversion(GO:0035822)
0.2 4.2 GO:0036503 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.1 0.4 GO:0015802 basic amino acid transport(GO:0015802)
0.1 0.6 GO:0032979 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.1 0.5 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.4 GO:0030100 regulation of endocytosis(GO:0030100)
0.1 0.4 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.1 0.4 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.2 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.1 0.1 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.1 0.2 GO:2001040 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.1 0.4 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.1 0.5 GO:0051274 beta-glucan biosynthetic process(GO:0051274)
0.1 0.5 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.1 GO:0051098 regulation of binding(GO:0051098)
0.1 0.4 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 0.4 GO:0015858 nucleoside transport(GO:0015858)
0.1 0.4 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 0.9 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.1 0.4 GO:0031578 mitotic spindle orientation checkpoint(GO:0031578)
0.1 0.3 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 1.1 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.1 0.3 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.1 0.3 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.1 0.1 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.0 0.4 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0046688 response to copper ion(GO:0046688)
0.0 0.0 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.1 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.1 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.0 GO:0051180 vitamin transport(GO:0051180)
0.0 0.1 GO:0015908 fatty acid transport(GO:0015908)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
15.9 47.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
8.2 24.6 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
6.3 31.4 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
5.3 21.2 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
4.8 57.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
4.7 60.8 GO:0005619 ascospore wall(GO:0005619)
4.6 18.5 GO:0042597 periplasmic space(GO:0042597)
4.5 13.6 GO:0031166 integral component of vacuolar membrane(GO:0031166)
4.2 16.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
3.9 11.7 GO:0045240 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
3.9 30.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
3.6 32.7 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
3.6 17.9 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
3.3 19.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
3.2 41.6 GO:0070469 respiratory chain(GO:0070469)
3.2 6.4 GO:0032126 eisosome(GO:0032126)
3.1 21.7 GO:0034657 GID complex(GO:0034657)
3.1 55.4 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
3.0 30.0 GO:0005775 vacuolar lumen(GO:0005775)
2.6 7.7 GO:0001400 mating projection base(GO:0001400)
2.1 23.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
2.0 4.0 GO:0030061 mitochondrial crista(GO:0030061)
1.9 22.6 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
1.7 5.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
1.7 6.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
1.4 9.5 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
1.3 4.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
1.3 28.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
1.1 17.1 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
1.1 3.2 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
1.0 18.7 GO:0005811 lipid particle(GO:0005811)
1.0 3.9 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.9 2.8 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.9 6.4 GO:0033101 cellular bud membrane(GO:0033101)
0.9 2.7 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.9 0.9 GO:0032585 multivesicular body membrane(GO:0032585)
0.8 38.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.8 3.2 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.8 123.2 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.7 4.2 GO:0008180 COP9 signalosome(GO:0008180)
0.7 1.4 GO:0044284 mitochondrial crista junction(GO:0044284)
0.7 2.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.6 1.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.6 17.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.6 30.0 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.6 1.1 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.5 2.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.5 408.8 GO:0005739 mitochondrion(GO:0005739)
0.5 2.5 GO:0005869 dynactin complex(GO:0005869)
0.5 1.5 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.4 7.5 GO:0070822 Sin3-type complex(GO:0070822)
0.4 1.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 2.4 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.4 0.4 GO:0030870 Mre11 complex(GO:0030870)
0.4 4.3 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.3 1.3 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.3 5.4 GO:0016592 mediator complex(GO:0016592)
0.3 1.0 GO:0033551 monopolin complex(GO:0033551)
0.2 0.5 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.2 0.4 GO:0070211 Snt2C complex(GO:0070211)
0.2 1.3 GO:0000795 synaptonemal complex(GO:0000795)
0.2 4.5 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.2 0.6 GO:0070847 core mediator complex(GO:0070847)
0.2 0.7 GO:0032116 SMC loading complex(GO:0032116)
0.2 0.5 GO:0005787 signal peptidase complex(GO:0005787)
0.2 2.0 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.2 1.0 GO:0034967 Set3 complex(GO:0034967)
0.2 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 4.3 GO:0010008 endosome membrane(GO:0010008)
0.1 5.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.8 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 1.6 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 1.4 GO:0000124 SAGA complex(GO:0000124)
0.1 0.8 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.1 2.2 GO:0005770 late endosome(GO:0005770)
0.1 1.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.8 GO:0000974 Prp19 complex(GO:0000974)
0.1 1.2 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.1 1.5 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.4 GO:0043614 multi-eIF complex(GO:0043614)
0.1 0.2 GO:0000417 HIR complex(GO:0000417)
0.0 0.2 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0031499 TRAMP complex(GO:0031499)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
17.6 52.7 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
15.9 47.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
13.5 40.6 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
13.4 67.0 GO:0015295 solute:proton symporter activity(GO:0015295)
13.4 53.4 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
11.0 33.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
9.6 28.8 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
8.9 26.6 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
8.4 33.5 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
8.3 24.9 GO:0016289 CoA hydrolase activity(GO:0016289)
7.6 30.4 GO:0004396 hexokinase activity(GO:0004396)
7.6 22.8 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
7.5 30.1 GO:0005537 mannose binding(GO:0005537)
7.2 29.0 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
7.0 21.0 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
6.6 19.9 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
6.3 31.4 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
6.2 24.8 GO:0004614 phosphoglucomutase activity(GO:0004614)
6.0 35.8 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
5.9 29.5 GO:0050308 sugar-phosphatase activity(GO:0050308)
5.3 31.5 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
5.0 34.9 GO:0016833 oxo-acid-lyase activity(GO:0016833)
4.8 67.7 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
4.8 38.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
4.7 33.1 GO:0004364 glutathione transferase activity(GO:0004364)
4.1 69.0 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
3.4 27.3 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
3.2 12.8 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
3.1 33.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
2.9 14.7 GO:0015294 solute:cation symporter activity(GO:0015294)
2.9 17.4 GO:0090599 alpha-glucosidase activity(GO:0090599)
2.6 7.9 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
2.6 10.5 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
2.6 10.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
2.6 12.9 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
2.5 7.6 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
2.5 5.0 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
2.5 9.8 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
2.4 9.5 GO:0004180 carboxypeptidase activity(GO:0004180)
2.3 9.3 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
2.3 27.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
2.3 9.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
2.3 2.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
2.3 13.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
2.2 2.2 GO:0032451 demethylase activity(GO:0032451)
2.0 10.2 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
2.0 10.0 GO:0015297 antiporter activity(GO:0015297)
2.0 16.0 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
2.0 23.8 GO:0022838 substrate-specific channel activity(GO:0022838)
2.0 21.5 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
1.9 15.4 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
1.9 5.7 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
1.9 5.6 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
1.8 9.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
1.8 5.4 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
1.8 18.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
1.8 8.9 GO:0008198 ferrous iron binding(GO:0008198)
1.8 3.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.8 134.2 GO:0051082 unfolded protein binding(GO:0051082)
1.7 6.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
1.7 5.1 GO:0070569 uridylyltransferase activity(GO:0070569)
1.6 7.9 GO:0017022 myosin binding(GO:0017022)
1.5 4.5 GO:0016872 intramolecular lyase activity(GO:0016872)
1.5 1.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
1.4 14.0 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
1.4 6.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
1.3 12.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
1.3 6.6 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
1.3 3.8 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
1.2 32.2 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
1.2 8.6 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
1.2 16.5 GO:0016831 carboxy-lyase activity(GO:0016831)
1.2 13.9 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
1.2 3.5 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
1.2 15.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
1.1 5.6 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
1.1 2.2 GO:0045118 azole transporter activity(GO:0045118)
1.1 3.3 GO:0015385 sodium:proton antiporter activity(GO:0015385)
1.1 3.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
1.0 12.2 GO:0099600 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
1.0 7.1 GO:0004713 protein tyrosine kinase activity(GO:0004713)
1.0 3.0 GO:0019776 Atg8 ligase activity(GO:0019776)
1.0 2.0 GO:0051185 coenzyme transporter activity(GO:0051185)
1.0 2.9 GO:0004629 phospholipase C activity(GO:0004629)
1.0 4.8 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.9 2.8 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.9 9.1 GO:0031386 protein tag(GO:0031386)
0.9 5.4 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.9 15.2 GO:0005507 copper ion binding(GO:0005507)
0.9 4.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.9 7.9 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.9 1.7 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091) TFIIH-class transcription factor binding(GO:0001097)
0.8 12.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.8 8.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.8 11.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.7 7.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.7 3.6 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.7 15.6 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.7 1.4 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.7 5.7 GO:0034979 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.7 3.5 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.7 26.3 GO:0043492 ATPase activity, coupled to movement of substances(GO:0043492)
0.7 1.3 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.6 1.3 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.6 9.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.6 3.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.6 2.5 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.6 7.3 GO:0045182 translation regulator activity(GO:0045182)
0.6 10.7 GO:0050661 NADP binding(GO:0050661)
0.6 4.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.5 2.2 GO:0016725 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5 2.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.5 2.1 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346) purine nucleoside transmembrane transporter activity(GO:0015211)
0.5 21.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.5 4.6 GO:0016722 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions(GO:0016722) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.5 0.5 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.5 5.5 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.5 0.5 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.5 1.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.5 1.4 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.5 0.9 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.5 6.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 2.7 GO:0005057 receptor signaling protein activity(GO:0005057)
0.4 1.3 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.4 1.7 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.4 1.7 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.4 2.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.4 0.4 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.4 7.4 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 1.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.4 1.1 GO:0097027 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) ubiquitin-protein transferase activator activity(GO:0097027)
0.4 9.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.4 0.4 GO:0051880 double-stranded telomeric DNA binding(GO:0003691) G-quadruplex DNA binding(GO:0051880)
0.4 25.3 GO:0005543 phospholipid binding(GO:0005543)
0.4 1.1 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.4 1.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.4 6.4 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.3 4.5 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.3 1.6 GO:0016783 sulfurtransferase activity(GO:0016783)
0.3 0.3 GO:0031072 heat shock protein binding(GO:0031072)
0.3 5.8 GO:0003713 transcription coactivator activity(GO:0003713)
0.3 1.4 GO:0008171 O-methyltransferase activity(GO:0008171)
0.3 9.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 4.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.3 0.8 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.2 2.2 GO:0035064 methylated histone binding(GO:0035064)
0.2 1.9 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.2 1.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.2 0.7 GO:0008169 C-methyltransferase activity(GO:0008169)
0.2 0.7 GO:0000150 recombinase activity(GO:0000150)
0.2 1.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.8 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 0.6 GO:0004458 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.2 0.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 0.6 GO:0070336 flap-structured DNA binding(GO:0070336)
0.2 2.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 2.2 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.2 0.3 GO:0005102 mating pheromone activity(GO:0000772) receptor binding(GO:0005102) pheromone activity(GO:0005186)
0.2 0.8 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 0.4 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 1.9 GO:0017171 serine hydrolase activity(GO:0017171)
0.1 9.2 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.1 0.4 GO:0032183 SUMO binding(GO:0032183)
0.1 0.8 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 0.8 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 1.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 1.6 GO:0005509 calcium ion binding(GO:0005509)
0.1 0.3 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.1 0.3 GO:0015293 symporter activity(GO:0015293)
0.1 2.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.6 GO:0032947 protein complex scaffold(GO:0032947)
0.1 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 1.3 GO:0031491 nucleosome binding(GO:0031491)
0.1 0.8 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 0.8 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.4 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 0.1 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.4 GO:0016298 lipase activity(GO:0016298)
0.0 1.7 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
9.0 26.9 PID IL4 2PATHWAY IL4-mediated signaling events
4.5 22.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
2.9 8.6 PID ERBB4 PATHWAY ErbB4 signaling events
2.5 7.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.5 4.5 PID FOXO PATHWAY FoxO family signaling
1.4 1.4 PID AR PATHWAY Coregulation of Androgen receptor activity
1.2 3.5 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
1.1 2.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
1.0 3.0 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.8 1.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.5 3.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.5 1.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4 601.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 0.1 PID AP1 PATHWAY AP-1 transcription factor network
0.1 0.3 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.0 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 32.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
5.0 55.0 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
4.0 8.1 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
2.0 5.9 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
1.2 3.5 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.7 2.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.7 1.3 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.5 4.1 REACTOME MEIOSIS Genes involved in Meiosis
0.4 1.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.4 578.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.3 0.7 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.3 1.1 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.2 1.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 0.5 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.1 0.6 REACTOME INNATE IMMUNE SYSTEM Genes involved in Innate Immune System
0.1 0.6 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 1.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression