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Results for GSM1

Z-value: 1.58

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Transcription factors associated with GSM1

Gene Symbol Gene ID Gene Info
GSM1
S000003639 Putative zinc cluster protein of unknown function

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GSM1YJL103C0.921.9e-11Click!

Activity profile of GSM1 motif

Sorted Z-values of GSM1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YLR377C 18.59
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YJR095W 17.51
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YJR048W 15.51
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YKR097W 14.67
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YPL223C 14.35
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YFR053C 13.64
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YLR174W 11.53
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YDR342C 11.50
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YJL045W 11.02 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YBR116C 9.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YLL041C 9.32
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YLR307C-A 8.80 Putative protein of unknown function
YPL024W 8.79
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YDR277C 8.76
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YAR053W 8.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR216W 8.55
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YJL116C 8.23
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YPR030W 8.19
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YMR244W 8.19 Putative protein of unknown function
YFL051C 7.92 Putative protein of unknown function; YFL051C is not an essential gene
YCR007C 7.85 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YML081C-A 7.72
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YPL026C 7.25
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YHR096C 7.25
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YKL171W 7.14 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YFL030W 7.09
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YOR343C 6.59 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YAL039C 6.44
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YKR009C 6.43
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YAR060C 6.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL064C 6.28
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YPL222W 6.23
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR034W-A 6.19 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YKL109W 5.93
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YGR144W 5.82
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YMR206W 5.72 Putative protein of unknown function; YMR206W is not an essential gene
YHR212C 5.64 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR070C 5.58
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL186C 5.42
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YDR343C 5.18
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YDL194W 5.12
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YOL084W 4.87
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YHR212W-A 4.87 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLR312C 4.87
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YGR256W 4.86
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YPL185W 4.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YER158C 4.77 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YDR406W 4.71
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YKL093W 4.64
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YPL201C 4.61
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YMR090W 4.59 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YDL210W 4.52
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YOL060C 4.40
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YIL125W 4.39
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YFL054C 4.38 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YKR015C 4.16 Putative protein of unknown function
YOR381W 4.15
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YOR192C 3.90
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YGR110W 3.89 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YAL018C 3.89 Putative protein of unknown function
YMR081C 3.88
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YBR201C-A 3.86 Putative protein of unknown function
YGL258W-A 3.83 Putative protein of unknown function
YCR005C 3.80
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YDL238C 3.77
GUD1
Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
YLR402W 3.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL205W 3.76
POX1
Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YLR403W 3.59
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YDL222C 3.54
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YIL057C 3.53 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YOR192C-C 3.44 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YDR298C 3.41
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YMR107W 3.40
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YLR111W 3.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR100C 3.30
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YDR536W 3.30
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YNL277W-A 3.29 Putative protein of unknown function
YML128C 3.29
MSC1
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YPR196W 3.26 Putative maltose activator
YDR022C 3.21
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YKL148C 3.19
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YMR104C 3.11
YPK2
Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YPL200W 3.04
CSM4
Protein required for accurate chromosome segregation during meiosis
YFL053W 2.98
DAK2
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YPL015C 2.94
HST2
Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YHR189W 2.89
PTH1
One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration
YLR296W 2.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR279W 2.85 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR021C 2.84
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YBL043W 2.81
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDR030C 2.81
RAD28
Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
YPL025C 2.80 Hypothetical protein
YML042W 2.80
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YGR032W 2.76
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YKR016W 2.75
AIM28
Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media
YKL031W 2.68 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YOL085W-A 2.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YLL053C 2.61 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YPL147W 2.61
PXA1
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YJL037W 2.58
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YDR031W 2.57
MIC14
Mitochondrial intermembrane space cysteine motif protein of 14 kDa
YDR528W 2.57
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YJL093C 2.56
TOK1
Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YKL133C 2.56 Putative protein of unknown function
YPL156C 2.55
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YLR295C 2.52
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YJL152W 2.48 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR289C 2.47
MAL11
Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; broad substrate specificity that includes maltotriose
YNL055C 2.43
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YLR324W 2.39
PEX30
Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
YGL215W 2.36
CLG1
Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
YJR151C 2.36
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YMR170C 2.35
ALD2
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YBR269C 2.33
FMP21
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR017W 2.32
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YHL024W 2.32
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YER033C 2.30
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YLL052C 2.30
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YER004W 2.30
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YNL144C 2.29 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YHL021C 2.26
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YOR388C 2.20
FDH1
NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
YML089C 2.19 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YGR290W 2.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)
YPL089C 2.18
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YLR152C 2.13 Putative protein of unknown function; YLR152C is not an essential gene
YHR139C 2.10
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YJL213W 2.06 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YPR007C 2.05
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YAL017W 2.05
PSK1
One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
YMR135C 2.04
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YML081W 2.04 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene
YDR173C 2.04
ARG82
Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
YOR374W 2.03
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YBR021W 2.02
FUR4
Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
YLL039C 2.02
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YDL085W 2.00
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YBR105C 1.99
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YNL240C 1.99
NAR1
Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YDL237W 1.94
LRC1
Putative protein of unknown function; YDL237W is not an essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YBR039W 1.91
ATP3
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YGR250C 1.90 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YMR182C 1.89
RGM1
Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth
YDR234W 1.88
LYS4
Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YDR043C 1.88
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YJR154W 1.87 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YPR027C 1.85 Putative protein of unknown function
YFL036W 1.85
RPO41
Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YGR129W 1.81
SYF2
Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression
YAL062W 1.81
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YOR371C 1.80
GPB1
Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p
YKL217W 1.78
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YOR072W 1.77 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YAL054C 1.75
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YJR152W 1.73
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YLR278C 1.70 Zinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene
YPL098C 1.70
MGR2
Protein required for growth of cells lacking the mitochondrial genome
YMR216C 1.69
SKY1
SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
YOR363C 1.67
PIP2
Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes
YNL045W 1.66 Leucyl aminopeptidase (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; role in vivo is not defined; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YJR146W 1.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YJL220W 1.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2
YIL070C 1.64
MAM33
Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
YDR441C 1.63
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YGR292W 1.63
MAL12
Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus
YDL246C 1.62
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YFL052W 1.62 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YGL096W 1.60
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YDR231C 1.59
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YJL038C 1.58
LOH1
Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W
YEL052W 1.58
AFG1
Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
YGL081W 1.56 Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
YCR010C 1.56
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YMR297W 1.55
PRC1
Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YNR001C 1.55
CIT1
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YMR194C-B 1.54 Putative protein of unknown function
YBR132C 1.53
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YLR281C 1.52 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
YPR160W 1.51
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YNL142W 1.51
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YOR071C 1.51
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YPL240C 1.51
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YPL222C-A 1.50 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLL013C 1.50
PUF3
Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
YLR280C 1.50 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL120W 1.50
QDR1
Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban
YPL088W 1.49 Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YIR027C 1.49
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YNL014W 1.48
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YDR254W 1.47
CHL4
Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p
YOR376W 1.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YIR029W 1.46
DAL2
Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YOL138C 1.45
RTC1
Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; null mutation suppresses cdc13-1 temperature sensitivity
YEL070W 1.44
DSF1
Deletion suppressor of mpt5 mutation
YLR431C 1.43
ATG23
Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway; cycles between the pre-autophagosome (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p
YJL221C 1.42
FSP2
Protein of unknown function, expression is induced during nitrogen limitation
YPR013C 1.42 Putative zinc finger protein; YPR013C is not an essential gene
YDR287W 1.41
INM2
Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
YDL214C 1.40
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YKL146W 1.40
AVT3
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

Network of associatons between targets according to the STRING database.

First level regulatory network of GSM1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 18.8 GO:0015755 fructose transport(GO:0015755)
4.6 13.7 GO:0015740 C4-dicarboxylate transport(GO:0015740)
3.4 10.2 GO:0046321 regulation of fatty acid beta-oxidation(GO:0031998) positive regulation of fatty acid beta-oxidation(GO:0032000) regulation of fatty acid oxidation(GO:0046320) positive regulation of fatty acid oxidation(GO:0046321)
2.8 13.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
2.5 12.4 GO:0006102 isocitrate metabolic process(GO:0006102)
2.4 7.1 GO:0006545 glycine biosynthetic process(GO:0006545)
2.3 18.6 GO:0015758 glucose transport(GO:0015758)
2.2 8.8 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
2.1 6.4 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.8 5.4 GO:0015888 thiamine transport(GO:0015888)
1.7 15.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
1.7 1.7 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
1.6 4.9 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
1.5 4.6 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
1.5 5.9 GO:0015847 putrescine transport(GO:0015847)
1.4 4.1 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
1.2 17.2 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
1.2 20.8 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
1.2 3.7 GO:0006740 NADPH regeneration(GO:0006740)
1.1 5.3 GO:0006097 glyoxylate cycle(GO:0006097)
1.0 9.2 GO:0006635 fatty acid beta-oxidation(GO:0006635)
1.0 2.9 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.9 2.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.9 12.1 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.9 8.2 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.9 6.0 GO:0000023 maltose metabolic process(GO:0000023)
0.8 3.3 GO:0006598 polyamine catabolic process(GO:0006598)
0.8 3.1 GO:0019748 secondary metabolic process(GO:0019748)
0.8 3.0 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.7 2.9 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.7 7.2 GO:0046686 response to cadmium ion(GO:0046686)
0.7 4.3 GO:0043457 regulation of cellular respiration(GO:0043457)
0.7 3.5 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.7 2.8 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.7 19.1 GO:0006094 gluconeogenesis(GO:0006094)
0.7 2.7 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.6 3.2 GO:0006083 acetate metabolic process(GO:0006083)
0.6 1.9 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.6 1.8 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.6 0.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.6 5.0 GO:0043269 regulation of ion transport(GO:0043269)
0.6 1.7 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.6 3.9 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.5 1.6 GO:0044209 AMP salvage(GO:0044209)
0.5 3.8 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.5 3.1 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.5 2.5 GO:0070941 eisosome assembly(GO:0070941)
0.5 2.0 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.5 2.0 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.5 3.5 GO:0015891 siderophore transport(GO:0015891)
0.5 1.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.5 1.5 GO:0034090 maintenance of meiotic sister chromatid cohesion(GO:0034090)
0.5 2.3 GO:0034486 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.4 2.7 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.4 1.8 GO:0006848 pyruvate transport(GO:0006848)
0.4 2.1 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.4 1.7 GO:0016241 regulation of macroautophagy(GO:0016241) negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.4 1.6 GO:0019568 arabinose metabolic process(GO:0019566) arabinose catabolic process(GO:0019568)
0.4 2.4 GO:0006279 premeiotic DNA replication(GO:0006279)
0.4 1.5 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.4 1.8 GO:0033500 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.4 1.1 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.4 0.7 GO:0019388 galactose catabolic process(GO:0019388)
0.4 1.8 GO:0043954 cellular component maintenance(GO:0043954)
0.3 5.8 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.3 1.3 GO:0032371 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.3 1.0 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.3 16.0 GO:0009060 aerobic respiration(GO:0009060)
0.3 1.5 GO:0005980 glycogen catabolic process(GO:0005980)
0.3 0.9 GO:0046113 nucleobase catabolic process(GO:0046113)
0.3 0.9 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.3 1.2 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.3 2.2 GO:0015893 drug transport(GO:0015893)
0.3 9.2 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.3 0.3 GO:0051099 positive regulation of binding(GO:0051099)
0.3 0.8 GO:0035376 sterol import(GO:0035376)
0.3 1.0 GO:0015793 glycerol transport(GO:0015793)
0.3 1.3 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.3 1.5 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.3 1.5 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.2 1.0 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.2 0.7 GO:0042407 cristae formation(GO:0042407)
0.2 1.2 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.2 0.7 GO:0006311 meiotic gene conversion(GO:0006311)
0.2 4.4 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.2 2.5 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.2 1.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.2 2.1 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 0.4 GO:2001040 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.2 1.9 GO:0046777 protein autophosphorylation(GO:0046777)
0.2 0.8 GO:0043200 response to amino acid(GO:0043200)
0.2 0.8 GO:0071168 protein localization to chromatin(GO:0071168)
0.2 2.2 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.2 1.0 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 1.0 GO:0006828 manganese ion transport(GO:0006828)
0.2 2.0 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.2 4.3 GO:0008361 regulation of cell size(GO:0008361)
0.2 0.8 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 1.0 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.2 0.9 GO:0060238 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238)
0.2 1.5 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.2 0.5 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.2 0.7 GO:0006012 galactose metabolic process(GO:0006012)
0.2 0.9 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.2 0.5 GO:0051596 glutathione biosynthetic process(GO:0006750) methylglyoxal metabolic process(GO:0009438) nonribosomal peptide biosynthetic process(GO:0019184) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 0.5 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.2 2.8 GO:0000209 protein polyubiquitination(GO:0000209)
0.2 0.8 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.2 0.6 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 2.3 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.2 0.3 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.1 0.7 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.6 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.1 0.9 GO:0016559 peroxisome fission(GO:0016559)
0.1 0.5 GO:0070988 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.1 0.4 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.1 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 4.6 GO:0070726 cell wall assembly(GO:0070726)
0.1 1.5 GO:0007129 synapsis(GO:0007129)
0.1 1.3 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 1.0 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.4 GO:0072337 modified amino acid transport(GO:0072337)
0.1 0.5 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 0.5 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.1 1.7 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.2 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.1 0.2 GO:0015851 nucleobase transport(GO:0015851)
0.1 3.9 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.8 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.7 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.4 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 0.9 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.1 0.3 GO:0005993 trehalose catabolic process(GO:0005993)
0.1 0.6 GO:0046337 phosphatidylethanolamine metabolic process(GO:0046337)
0.1 0.7 GO:0031167 rRNA methylation(GO:0031167)
0.1 2.8 GO:0007031 peroxisome organization(GO:0007031)
0.1 1.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.2 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 0.3 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.2 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1 0.3 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 0.4 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.1 0.5 GO:0000321 re-entry into mitotic cell cycle(GO:0000320) re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 1.2 GO:0016579 protein deubiquitination(GO:0016579)
0.1 1.5 GO:0030437 ascospore formation(GO:0030437) cell development(GO:0048468)
0.1 0.5 GO:0005977 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.1 0.2 GO:0031297 replication fork processing(GO:0031297)
0.1 0.1 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 0.5 GO:0034476 U5 snRNA 3'-end processing(GO:0034476)
0.1 0.2 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.1 0.8 GO:0023014 MAPK cascade(GO:0000165) signal transduction by protein phosphorylation(GO:0023014)
0.0 0.3 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.0 0.5 GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0000750) signal transduction involved in conjugation with cellular fusion(GO:0032005)
0.0 0.3 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.0 0.2 GO:0019400 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.0 0.6 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.0 1.0 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0 0.1 GO:0009746 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.0 0.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.8 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.6 GO:0046785 microtubule nucleation(GO:0007020) microtubule polymerization(GO:0046785)
0.0 0.2 GO:0070058 tRNA gene clustering(GO:0070058)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.2 GO:0006826 iron ion transport(GO:0006826)
0.0 0.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.1 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.2 GO:0015918 sterol transport(GO:0015918)
0.0 0.2 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.0 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.0 0.0 GO:0019433 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.8 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
2.8 13.8 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
2.1 17.1 GO:0042597 periplasmic space(GO:0042597)
1.7 15.3 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
1.6 6.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.6 4.9 GO:0045240 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.9 2.8 GO:0046930 pore complex(GO:0046930)
0.8 16.8 GO:0070469 respiratory chain(GO:0070469)
0.7 2.8 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.6 1.9 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.6 4.0 GO:0034657 GID complex(GO:0034657)
0.5 1.0 GO:0032126 eisosome(GO:0032126)
0.4 26.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 1.8 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.3 0.7 GO:0044284 mitochondrial crista junction(GO:0044284)
0.3 1.0 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.3 4.2 GO:0005619 ascospore wall(GO:0005619)
0.3 0.9 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.3 1.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 12.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 1.0 GO:0030128 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.2 1.9 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 0.6 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 1.0 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.2 0.8 GO:0032221 Rpd3S complex(GO:0032221)
0.1 0.9 GO:0034967 Set3 complex(GO:0034967)
0.1 1.8 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 3.4 GO:0031201 SNARE complex(GO:0031201)
0.1 2.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 1.0 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 0.8 GO:0000127 transcription factor TFIIIC complex(GO:0000127) condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.1 0.5 GO:0070209 ASTRA complex(GO:0070209)
0.1 100.3 GO:0005739 mitochondrion(GO:0005739)
0.1 1.0 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.2 GO:0070211 Snt2C complex(GO:0070211)
0.1 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.1 1.3 GO:0000942 condensed chromosome outer kinetochore(GO:0000940) condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 0.7 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 0.3 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 2.2 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 0.8 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.5 GO:0033263 CORVET complex(GO:0033263)
0.1 2.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.2 GO:0001400 mating projection base(GO:0001400)
0.1 0.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.3 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 9.3 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 0.3 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.7 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0031968 outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 0.1 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0070210 Rpd3L complex(GO:0033698) Rpd3L-Expanded complex(GO:0070210)
0.0 0.2 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.4 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
3.6 14.6 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
3.5 17.6 GO:0050308 sugar-phosphatase activity(GO:0050308)
3.4 13.6 GO:0004396 hexokinase activity(GO:0004396)
2.8 13.8 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
2.3 11.5 GO:0015295 solute:proton symporter activity(GO:0015295)
2.1 8.6 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.8 7.3 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
1.8 5.3 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.7 5.1 GO:0005536 glucose binding(GO:0005536)
1.5 16.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.5 8.7 GO:0000400 four-way junction DNA binding(GO:0000400)
1.4 4.1 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
1.2 6.1 GO:0008198 ferrous iron binding(GO:0008198)
1.1 6.7 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.1 4.4 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
1.0 3.0 GO:0016208 AMP binding(GO:0016208)
0.9 2.8 GO:0015288 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.9 2.8 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.9 2.7 GO:0016289 CoA hydrolase activity(GO:0016289)
0.9 6.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.8 2.4 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.8 8.0 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.7 7.4 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.7 2.1 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.7 1.4 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.7 8.5 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.6 2.6 GO:0005261 cation channel activity(GO:0005261)
0.6 1.8 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.6 2.4 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.6 2.9 GO:0070403 NAD+ binding(GO:0070403)
0.6 2.3 GO:0005537 mannose binding(GO:0005537)
0.5 4.8 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.5 10.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.5 1.4 GO:0015658 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.5 0.9 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.4 7.9 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 1.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 2.0 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.4 1.6 GO:0004180 carboxypeptidase activity(GO:0004180)
0.4 2.3 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.4 6.3 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.3 2.4 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.3 1.7 GO:0042887 amide transmembrane transporter activity(GO:0042887)
0.3 1.4 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.3 6.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 1.8 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.3 1.2 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.3 1.1 GO:0016531 copper chaperone activity(GO:0016531)
0.3 0.8 GO:0032183 SUMO binding(GO:0032183)
0.3 0.5 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.2 1.5 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.2 0.7 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.2 2.1 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2 0.9 GO:0000156 phosphorelay response regulator activity(GO:0000156) osmosensor activity(GO:0005034)
0.2 4.4 GO:0050661 NADP binding(GO:0050661)
0.2 2.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.2 0.9 GO:0022821 calcium ion transmembrane transporter activity(GO:0015085) potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.2 1.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 2.6 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.2 5.1 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 1.0 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.2 2.0 GO:0031386 protein tag(GO:0031386)
0.2 1.0 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.2 2.2 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.2 0.9 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.2 0.5 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.2 0.7 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.2 0.7 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.2 0.5 GO:0016417 S-acyltransferase activity(GO:0016417)
0.2 0.3 GO:0032452 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) histone demethylase activity(GO:0032452) histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 0.9 GO:0030246 carbohydrate binding(GO:0030246)
0.2 4.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.2 6.6 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 1.0 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 3.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.8 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.8 GO:0001034 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.1 1.2 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 0.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.1 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.1 1.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 0.7 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 1.2 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.1 1.1 GO:0035064 methylated histone binding(GO:0035064)
0.1 11.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 1.7 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 0.3 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 3.3 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.5 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
0.1 0.7 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.1 0.3 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.1 0.3 GO:0000150 recombinase activity(GO:0000150)
0.1 0.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.4 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 0.6 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 1.4 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 1.1 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 1.4 GO:0004843 obsolete ubiquitin thiolesterase activity(GO:0004221) thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 1.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.1 GO:0051087 chaperone binding(GO:0051087)
0.1 0.5 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.5 GO:0043495 protein anchor(GO:0043495)
0.0 0.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.1 GO:0050662 coenzyme binding(GO:0050662)
0.0 1.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 1.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.3 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.3 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.1 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.2 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 0.0 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.0 9.0 PID FANCONI PATHWAY Fanconi anemia pathway
0.6 1.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 1.6 PID PLK1 PATHWAY PLK1 signaling events
0.2 1.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 0.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.4 PID CMYB PATHWAY C-MYB transcription factor network
0.1 0.3 PID P73PATHWAY p73 transcription factor network
0.1 0.1 PID AP1 PATHWAY AP-1 transcription factor network
0.1 84.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.5 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
3.7 33.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.9 2.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.6 1.9 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.4 0.7 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.3 1.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.4 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.1 0.5 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.1 84.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME MEIOSIS Genes involved in Meiosis
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane