Results for HAP3
Z-value: 3.56
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Transcription factors associated with HAP3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HAP3
|
S000000117 | Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YAL062W Show fit | 56.74 |
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources |
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| YLR174W Show fit | 34.80 |
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose |
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| YML089C Show fit | 30.99 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage |
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| YBR201C-A Show fit | 30.45 |
Putative protein of unknown function |
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| YOR343C Show fit | 28.28 |
Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data |
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| YDR536W Show fit | 28.08 |
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
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| YNL117W Show fit | 22.45 |
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium |
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| YBR117C Show fit | 22.34 |
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids |
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| YDL067C Show fit | 21.28 |
Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain |
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| YGL062W Show fit | 20.65 |
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis |
Network of associatons between targets according to the STRING database.
First level regulatory network of HAP3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.1 | 100.3 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 7.1 | 99.3 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 7.6 | 68.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 8.0 | 63.9 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 5.6 | 44.9 | GO:0006119 | oxidative phosphorylation(GO:0006119) |
| 12.2 | 36.7 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 4.4 | 35.1 | GO:0015891 | siderophore transport(GO:0015891) |
| 5.4 | 32.4 | GO:0000501 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 0.8 | 29.4 | GO:0009060 | aerobic respiration(GO:0009060) |
| 5.2 | 26.1 | GO:0015793 | glycerol transport(GO:0015793) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 133.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 9.0 | 80.9 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) |
| 8.0 | 71.8 | GO:0070069 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) cytochrome complex(GO:0070069) |
| 0.4 | 61.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.2 | 60.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 11.2 | 33.6 | GO:0000274 | mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265) |
| 5.1 | 30.9 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 4.8 | 24.2 | GO:0098803 | mitochondrial respiratory chain(GO:0005746) respiratory chain complex(GO:0098803) |
| 7.5 | 22.6 | GO:0045269 | mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269) |
| 1.9 | 22.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 80.9 | GO:0016675 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 7.3 | 80.3 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 8.4 | 67.4 | GO:0016679 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 13.2 | 39.5 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 9.2 | 36.7 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 8.1 | 32.4 | GO:0005537 | mannose binding(GO:0005537) |
| 5.6 | 28.1 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 1.4 | 27.4 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 6.3 | 25.1 | GO:0016885 | ligase activity, forming carbon-carbon bonds(GO:0016885) |
| 3.1 | 25.1 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 144.4 | PID IFNG PATHWAY | IFN-gamma pathway |
| 4.1 | 12.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 2.7 | 8.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.8 | 7.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 2.2 | 6.6 | PID FOXO PATHWAY | FoxO family signaling |
| 0.6 | 1.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.5 | 1.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 1.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.4 | 1.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.5 | 0.5 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 144.4 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 1.5 | 13.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.5 | 13.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 4.0 | 12.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 3.1 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.8 | 2.5 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.6 | 1.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 1.5 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.1 | 0.8 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.2 | 0.7 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |