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Results for HAP4

Z-value: 2.74

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Transcription factors associated with HAP4

Gene Symbol Gene ID Gene Info
HAP4
S000001592 Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HAP4YKL109W0.891.0e-09Click!

Activity profile of HAP4 motif

Sorted Z-values of HAP4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YAL062W 41.65
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YJR095W 21.20
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YDR536W 21.18
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YER065C 20.96
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YNL052W 18.47
COX5A
Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YBL015W 14.49
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YNR002C 14.41
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YBR117C 13.71
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YJR078W 13.63
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YDL181W 13.60
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YKL148C 13.18
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YKL141W 12.11
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YPR010C-A 12.08 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YFR017C 11.91 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YBL099W 11.79
ATP1
Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YAL063C 11.74
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YMR256C 11.08
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YIL125W 10.67
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YBL100C 10.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YBR201C-A 10.32 Putative protein of unknown function
YCR005C 10.22
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YEL008W 10.20 Hypothetical protein predicted to be involved in metabolism
YBL030C 10.20
PET9
Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
YML087C 10.19
AIM33
Putative protein of unknown function; highly conserved across species and orthologous to human CYB5R4; null mutant shows increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YIL136W 10.14
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YMR175W 10.11
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YHR139C 10.10
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YML089C 10.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YDR298C 10.00
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YEL009C 9.64
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YLR023C 9.35
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YIL057C 9.30 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YCR091W 9.30
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YBR230C 8.84
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YGR183C 8.83
QCR9
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YDL067C 8.82
COX9
Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YEL024W 8.81
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YPL024W 8.80
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YPL262W 8.80
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YKR009C 8.77
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YKL085W 8.62
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YLR038C 8.57
COX12
Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated
YMR107W 8.28
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YIL162W 8.16
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YML120C 7.78
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YEL035C 7.61
UTR5
Protein of unknown function; transcription may be regulated by Gcr1p
YJR077C 7.53
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YJL103C 7.43
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YDR377W 7.40
ATP17
Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YML081C-A 7.31
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YMR280C 7.31
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YPL271W 7.27
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YDR178W 7.21
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YLR296W 7.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR027C 7.10 Putative protein of unknown function
YDR529C 7.10
QCR7
Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
YDR034C 7.01
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YDL204W 6.98
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YFR049W 6.96
YMR31
Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
YPR036W-A 6.86 Protein of unknown function; transcription is regulated by Pdr1p
YHR212C 6.83 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL026C 6.80
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YBL048W 6.75 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YIR029W 6.71
DAL2
Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YLR304C 6.71
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YAR053W 6.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL190W 6.61 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YKL163W 6.60
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YLL019C 6.55
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YFL019C 6.55 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YJL116C 6.52
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YLR295C 6.40
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YLR122C 6.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YER066W 6.37 Putative protein of unknown function; YER066W is not an essential gene
YCL057C-A 6.35 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR186C-A 6.28 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGL104C 6.24
VPS73
Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
YML090W 6.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YOR121C 6.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
YLR395C 6.17
COX8
Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YHL036W 6.13
MUP3
Low affinity methionine permease, similar to Mup1p
YIL059C 6.03 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YLL020C 6.01 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1
YKR102W 5.98
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YNL055C 5.93
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YFR053C 5.91
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YHR212W-A 5.89 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHL021C 5.83
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YDR322C-A 5.76
TIM11
Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase
YKL146W 5.76
AVT3
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YBR250W 5.76
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YHR001W-A 5.72
QCR10
Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YOR147W 5.71
MDM32
Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YHR096C 5.66
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YKL147C 5.57 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YKL016C 5.53
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YLR123C 5.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YOL077W-A 5.32
ATP19
Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase
YNR001C 5.26
CIT1
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YKR049C 5.24
FMP46
Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL059W 5.24 Dubious open reading frame unlikely to encode a functional protein
YCL001W-B 5.22 Putative protein of unknown function; identified by homology
YNL277W-A 5.22 Putative protein of unknown function
YNL074C 5.18
MLF3
Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YAR060C 5.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL038W 5.09
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YML054C 5.04
CYB2
Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YGR243W 5.04
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL102W 4.98
MEF2
Mitochondrial elongation factor involved in translational elongation
YER014C-A 4.98
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YFL030W 4.81
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YPR151C 4.80
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YFL051C 4.75 Putative protein of unknown function; YFL051C is not an essential gene
YMR118C 4.69 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YDR148C 4.64
KGD2
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
YPL189C-A 4.63
COA2
Putative cytochrome oxidase assembly factor; identified by homology to Ashbya gossypii; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity
YPR020W 4.60
ATP20
Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
YKL109W 4.56
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YHR008C 4.54
SOD2
Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YML091C 4.51
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YGR019W 4.47
UGA1
Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization
YKL151C 4.42 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YPR007C 4.42
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YPL078C 4.29
ATP4
Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YIL146C 4.25
ECM37
Non-essential protein of unknown function
YGL258W-A 4.22 Putative protein of unknown function
YJL088W 4.21
ARG3
Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
YLR393W 4.13
ATP10
Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
YFL020C 4.13
PAU5
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDR470C 4.10
UGO1
Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion
YKR097W 4.08
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YLR037C 4.05
DAN2
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YFL055W 4.01
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YOL084W 4.00
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YMR174C 3.93
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YAL067C 3.93
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YLR174W 3.87
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YGR268C 3.84
HUA1
Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YOR178C 3.83
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YDL176W 3.83 Putative protein of unknown function; YDL176W is not an essential gene
YBR230W-A 3.77 Putative protein of unknown function
YDL114W 3.77 Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
YGR236C 3.72
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLL009C 3.71
COX17
Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase
YIL017C 3.70
VID28
Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
YHL040C 3.69
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YCR021C 3.68
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YBR292C 3.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YMR002W 3.67
MIC17
Mitochondrial intermembrane space cysteine motif protein; MIC17 is not an essential gene
YKR101W 3.63
SIR1
Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
YLR124W 3.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLL001W 3.57
DNM1
Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis
YJR019C 3.55
TES1
Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
YBR033W 3.52
EDS1
Putative zinc cluster protein; YBR033W is not an essential gene
YDR263C 3.49
DIN7
Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination
YCL054W 3.46
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YJR151C 3.46
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YJR020W 3.46 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR473C 3.39
PRP3
Splicing factor, component of the U4/U6-U5 snRNP complex
YMR105C 3.34
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YFL011W 3.33
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YGL072C 3.31 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YKL177W 3.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YDL140C 3.31
RPO21
RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
YEL028W 3.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR009W 3.29
GAL3
Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
YPL250C 3.29
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YLR125W 3.27 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YOR376W 3.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YLR297W 3.26 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YPL183W-A 3.24
RTC6
Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome; null mutation suppresses cdc13-1 temperature sensitivity
YDR216W 3.22
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YGR059W 3.18
SPR3
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI
YKR011C 3.16 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YHR092C 3.13
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YNR073C 3.07 Putative mannitol dehydrogenase
YEL007W 3.07 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YER166W 3.04
DNF1
Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YKR015C 3.03 Putative protein of unknown function
YDR231C 2.97
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YKL150W 2.97
MCR1
Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
YKR100C 2.96
SKG1
Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
YJL199C 2.93
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YHL041W 2.91 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOR285W 2.90 Protein of unknown function, localized to the mitochondrial outer membrane
YAR050W 2.89
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YHR145C 2.89 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL025C 2.88 Hypothetical protein
YGL140C 2.87 Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
YLL039C 2.84
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YPR028W 2.82
YOP1
Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells
YPR150W 2.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YBR218C 2.76
PYC2
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YGL139W 2.74
FLC3
Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
YLR073C 2.73 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; YLR073C is not an esssential gene
YER098W 2.72
UBP9
Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YLR332W 2.71
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YIL160C 2.67
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YOR343C 2.67 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YER165C-A 2.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DNF1/YER166W

Network of associatons between targets according to the STRING database.

First level regulatory network of HAP4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.6 34.7 GO:0019676 ammonia assimilation cycle(GO:0019676)
6.8 33.9 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
6.6 19.9 GO:0015740 C4-dicarboxylate transport(GO:0015740)
5.8 17.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
5.7 79.1 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
4.8 43.4 GO:0006097 glyoxylate cycle(GO:0006097)
4.8 43.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
4.5 22.3 GO:0015793 glycerol transport(GO:0015793)
4.3 47.5 GO:0006119 oxidative phosphorylation(GO:0006119)
3.8 15.3 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
3.2 3.2 GO:0097306 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
3.1 18.7 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
3.0 15.0 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
2.9 8.6 GO:0006108 malate metabolic process(GO:0006108)
2.8 11.0 GO:0046323 glucose import(GO:0046323)
2.7 10.8 GO:0071462 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
2.6 10.4 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
2.5 10.2 GO:0015867 ATP transport(GO:0015867) heme transport(GO:0015886)
2.4 9.6 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
2.3 15.9 GO:0006083 acetate metabolic process(GO:0006083)
2.1 19.2 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
2.0 13.8 GO:0015758 glucose transport(GO:0015758)
1.8 16.2 GO:0006635 fatty acid beta-oxidation(GO:0006635)
1.7 6.8 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
1.7 8.3 GO:0044746 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
1.6 4.8 GO:0006545 glycine biosynthetic process(GO:0006545)
1.6 20.5 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
1.4 4.3 GO:0072353 cellular age-dependent response to reactive oxygen species(GO:0072353)
1.3 6.7 GO:0043954 cellular component maintenance(GO:0043954)
1.3 3.9 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
1.3 7.7 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
1.2 5.0 GO:0006848 pyruvate transport(GO:0006848)
1.2 9.9 GO:0045332 phospholipid translocation(GO:0045332)
1.2 6.1 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
1.2 3.6 GO:0006343 establishment of chromatin silencing(GO:0006343)
1.2 5.9 GO:0044070 regulation of anion transport(GO:0044070)
1.2 9.5 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
1.2 18.9 GO:0019740 nitrogen utilization(GO:0019740)
1.2 2.3 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
1.1 10.0 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
1.0 15.2 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
1.0 5.1 GO:0008053 mitochondrial fusion(GO:0008053)
1.0 2.9 GO:0015888 thiamine transport(GO:0015888)
0.9 2.7 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061395) cellular response to arsenic-containing substance(GO:0071243) negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.8 5.0 GO:0006089 lactate metabolic process(GO:0006089)
0.8 3.3 GO:0000435 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.8 5.7 GO:0000266 mitochondrial fission(GO:0000266)
0.8 4.0 GO:0043457 regulation of cellular respiration(GO:0043457)
0.8 3.1 GO:0015847 putrescine transport(GO:0015847)
0.8 1.5 GO:0000101 sulfur amino acid transport(GO:0000101)
0.8 0.8 GO:0097035 lipid translocation(GO:0034204) regulation of membrane lipid distribution(GO:0097035)
0.8 2.3 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.7 2.2 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.7 5.9 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.7 2.7 GO:0015883 FAD transport(GO:0015883)
0.7 2.7 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.7 3.3 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.7 5.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.6 1.8 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.6 4.1 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.6 2.3 GO:0015976 carbon utilization(GO:0015976)
0.6 5.1 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.6 1.1 GO:0043270 positive regulation of ion transport(GO:0043270)
0.6 2.2 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.5 3.8 GO:0043461 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.5 0.5 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.5 6.4 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.5 1.5 GO:0042743 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.5 1.9 GO:0071467 cellular response to pH(GO:0071467)
0.5 3.8 GO:0006591 ornithine metabolic process(GO:0006591)
0.5 0.5 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.5 0.5 GO:0051503 adenine nucleotide transport(GO:0051503)
0.5 1.8 GO:0019748 secondary metabolic process(GO:0019748)
0.5 2.3 GO:0000023 maltose metabolic process(GO:0000023)
0.4 2.7 GO:0015802 basic amino acid transport(GO:0015802)
0.4 4.0 GO:0031167 rRNA methylation(GO:0031167)
0.4 11.3 GO:0098656 anion transmembrane transport(GO:0098656)
0.4 1.7 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.4 7.7 GO:0006094 gluconeogenesis(GO:0006094)
0.4 1.6 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.4 1.1 GO:0046113 nucleobase catabolic process(GO:0046113)
0.4 1.1 GO:0046688 response to copper ion(GO:0046688)
0.3 1.0 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.3 3.7 GO:0015893 drug transport(GO:0015893)
0.3 1.0 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.3 2.5 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.3 1.5 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.3 2.4 GO:0070987 error-free translesion synthesis(GO:0070987)
0.3 2.1 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.3 2.1 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.3 12.3 GO:0042244 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.3 3.3 GO:0015914 phospholipid transport(GO:0015914)
0.3 0.8 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.3 1.1 GO:0000409 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.3 0.8 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.3 1.6 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.3 1.8 GO:0019722 calcium-mediated signaling(GO:0019722)
0.3 1.0 GO:0032371 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.3 4.5 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.2 0.7 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.2 1.7 GO:0015891 siderophore transport(GO:0015891)
0.2 1.7 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.2 4.9 GO:0016579 protein deubiquitination(GO:0016579)
0.2 1.0 GO:0051352 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.2 1.1 GO:0006279 premeiotic DNA replication(GO:0006279)
0.2 0.4 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.2 0.9 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.2 1.2 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.2 0.4 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.2 2.1 GO:0046173 polyol biosynthetic process(GO:0046173)
0.2 0.9 GO:0032979 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979)
0.2 0.9 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.2 1.0 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.2 0.5 GO:0051346 negative regulation of hydrolase activity(GO:0051346)
0.2 4.8 GO:0009060 aerobic respiration(GO:0009060)
0.2 0.5 GO:0006546 glycine catabolic process(GO:0006546)
0.2 2.2 GO:0042493 response to drug(GO:0042493)
0.2 0.2 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.1 2.1 GO:0001300 chronological cell aging(GO:0001300)
0.1 0.6 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 1.0 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 0.3 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.1 0.4 GO:0032365 intracellular lipid transport(GO:0032365)
0.1 0.5 GO:0046464 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.1 3.9 GO:0006184 obsolete GTP catabolic process(GO:0006184)
0.1 1.2 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.1 0.2 GO:0042148 strand invasion(GO:0042148)
0.1 0.5 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.1 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.5 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.5 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.2 GO:1903321 negative regulation of protein ubiquitination(GO:0031397) negative regulation of protein modification by small protein conjugation or removal(GO:1903321)
0.1 0.4 GO:0006048 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.3 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.1 0.5 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.2 GO:0010676 positive regulation of cellular carbohydrate metabolic process(GO:0010676) positive regulation of carbohydrate metabolic process(GO:0045913)
0.1 1.3 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.1 0.3 GO:0030007 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.1 0.3 GO:0051228 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.1 0.2 GO:0008272 sulfate transport(GO:0008272)
0.1 0.7 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.2 GO:0042407 cristae formation(GO:0042407)
0.1 0.5 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.2 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1 1.8 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 1.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.4 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.8 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.2 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.6 GO:0006865 amino acid transport(GO:0006865)
0.1 0.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.3 GO:0015858 nucleoside transport(GO:0015858)
0.1 0.4 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.2 GO:0051181 cofactor transport(GO:0051181)
0.1 0.2 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.1 0.8 GO:0009651 response to salt stress(GO:0009651)
0.1 0.3 GO:0032447 protein urmylation(GO:0032447)
0.1 0.1 GO:0001112 DNA-templated transcriptional open complex formation(GO:0001112) protein-DNA complex remodeling(GO:0001120) macromolecular complex remodeling(GO:0034367)
0.1 0.4 GO:0006816 calcium ion transport(GO:0006816)
0.1 0.3 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 0.2 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.0 0.1 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.0 1.4 GO:1902408 cellular bud site selection(GO:0000282) mitotic cytokinesis, site selection(GO:1902408)
0.0 0.9 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.0 2.1 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.3 GO:0009306 protein secretion(GO:0009306)
0.0 0.6 GO:0031929 TOR signaling(GO:0031929)
0.0 0.4 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.0 0.4 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.7 GO:0007265 Ras protein signal transduction(GO:0007265)
0.0 0.2 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 1.1 GO:0030435 sporulation resulting in formation of a cellular spore(GO:0030435)
0.0 0.1 GO:0017004 cytochrome complex assembly(GO:0017004)
0.0 0.1 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.0 0.7 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.6 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.1 GO:0051601 exocyst localization(GO:0051601)
0.0 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.1 GO:0034982 protein processing involved in protein targeting to mitochondrion(GO:0006627) mitochondrial protein processing(GO:0034982)
0.0 0.2 GO:0051031 tRNA transport(GO:0051031)
0.0 0.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.1 GO:0046174 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563) polyol catabolic process(GO:0046174)
0.0 0.1 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.1 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.4 GO:0030437 ascospore formation(GO:0030437) cell development(GO:0048468)
0.0 1.5 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.0 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.2 GO:0008361 regulation of cell size(GO:0008361)
0.0 0.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 33.9 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
6.6 19.8 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
6.1 36.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
5.8 51.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
5.1 15.3 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
4.5 22.5 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
3.7 11.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
3.6 32.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
2.9 8.8 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
2.0 5.9 GO:0046930 pore complex(GO:0046930)
1.5 26.2 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
1.3 5.0 GO:0070469 respiratory chain(GO:0070469)
1.1 4.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.0 13.6 GO:0005619 ascospore wall(GO:0005619)
0.9 2.6 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.8 5.5 GO:0034657 GID complex(GO:0034657)
0.6 1.2 GO:0005618 cell wall(GO:0005618) external encapsulating structure(GO:0030312)
0.6 3.0 GO:0044233 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.6 2.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.6 1.1 GO:0030061 mitochondrial crista(GO:0030061)
0.5 3.8 GO:0033101 cellular bud membrane(GO:0033101)
0.5 3.6 GO:0005677 chromatin silencing complex(GO:0005677)
0.5 1.5 GO:0032585 multivesicular body membrane(GO:0032585)
0.5 11.2 GO:0098573 intrinsic component of mitochondrial membrane(GO:0098573)
0.5 8.0 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.5 0.9 GO:0032126 eisosome(GO:0032126)
0.5 1.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.5 4.5 GO:0030677 ribonuclease P complex(GO:0030677)
0.4 3.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 1.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.4 29.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 1.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 12.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.4 50.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 6.0 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 1.0 GO:0033255 SAS acetyltransferase complex(GO:0033255)
0.3 3.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 1.4 GO:0031932 TORC2 complex(GO:0031932)
0.2 112.4 GO:0005739 mitochondrion(GO:0005739)
0.2 1.3 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 1.1 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 0.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 1.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 5.9 GO:0009277 fungal-type cell wall(GO:0009277)
0.1 4.7 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.1 0.4 GO:0016587 Isw1 complex(GO:0016587)
0.1 0.3 GO:0005871 kinesin complex(GO:0005871)
0.1 0.6 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.5 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.3 GO:0016592 mediator complex(GO:0016592)
0.1 0.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.3 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.3 GO:0034967 Set3 complex(GO:0034967)
0.0 0.6 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.6 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.0 0.3 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.6 GO:0005682 U5 snRNP(GO:0005682)
0.0 1.7 GO:0030479 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.0 11.6 GO:0005886 plasma membrane(GO:0005886)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.2 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013)
0.0 0.3 GO:0005769 early endosome(GO:0005769)
0.0 2.2 GO:0000329 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.0 0.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.0 0.1 GO:0000145 exocyst(GO:0000145)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.7 34.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
6.8 33.9 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
6.0 18.0 GO:0016289 CoA hydrolase activity(GO:0016289)
5.9 64.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
5.2 26.1 GO:0015295 solute:proton symporter activity(GO:0015295)
5.2 51.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
5.2 15.5 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
5.2 20.6 GO:0005537 mannose binding(GO:0005537)
5.0 19.9 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
4.0 32.3 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
3.4 10.1 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
3.1 9.2 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
3.0 21.0 GO:0016833 oxo-acid-lyase activity(GO:0016833)
2.7 10.7 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
2.6 7.9 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
2.6 15.4 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
2.5 10.2 GO:0005471 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
2.4 19.5 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
2.2 6.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
2.0 5.9 GO:0008308 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
1.9 5.8 GO:0015186 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
1.8 5.5 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.6 6.3 GO:0004457 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
1.5 5.9 GO:0004396 hexokinase activity(GO:0004396)
1.5 7.3 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
1.4 8.6 GO:0000400 four-way junction DNA binding(GO:0000400)
1.3 3.9 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
1.2 4.9 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
1.2 6.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
1.2 3.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.2 2.4 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
1.1 14.6 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
1.1 12.9 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.9 3.7 GO:0016531 copper chaperone activity(GO:0016531)
0.9 3.4 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.8 3.3 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.7 5.9 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.7 3.7 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.7 5.6 GO:0031072 heat shock protein binding(GO:0031072)
0.7 6.9 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.7 2.7 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.6 6.4 GO:0015293 symporter activity(GO:0015293)
0.6 5.0 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.6 1.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.6 1.8 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.6 1.8 GO:0005536 glucose binding(GO:0005536)
0.6 8.9 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.6 10.4 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.6 3.4 GO:0043177 amino acid binding(GO:0016597) carboxylic acid binding(GO:0031406) organic acid binding(GO:0043177)
0.6 14.5 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.6 0.6 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.5 4.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.5 2.0 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.5 1.9 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.5 0.5 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.5 4.5 GO:0004526 ribonuclease P activity(GO:0004526)
0.4 1.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.4 1.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.4 3.2 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.4 1.6 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.4 1.1 GO:0045118 azole transporter activity(GO:0045118)
0.4 2.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 3.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.4 3.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.4 1.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.4 16.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.3 1.0 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.3 1.6 GO:0008198 ferrous iron binding(GO:0008198)
0.3 4.7 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.3 3.5 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.3 3.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.3 1.7 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 0.9 GO:0032183 SUMO binding(GO:0032183)
0.3 2.8 GO:0031386 protein tag(GO:0031386)
0.2 0.7 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.2 2.0 GO:0035064 methylated histone binding(GO:0035064)
0.2 0.9 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.2 2.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 0.9 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129)
0.2 0.6 GO:0016882 cyclo-ligase activity(GO:0016882)
0.2 1.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 2.9 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 0.2 GO:0004075 biotin carboxylase activity(GO:0004075)
0.2 0.7 GO:0004180 carboxypeptidase activity(GO:0004180)
0.2 0.8 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 0.5 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.2 1.8 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.2 1.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 1.5 GO:0019239 deaminase activity(GO:0019239)
0.1 0.7 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.1 6.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 2.2 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.1 0.5 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 0.5 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.4 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 2.5 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221) thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 1.1 GO:0090484 drug transmembrane transporter activity(GO:0015238) drug transporter activity(GO:0090484)
0.1 1.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.9 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.0 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 0.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.7 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 8.4 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.8 GO:0010181 FMN binding(GO:0010181)
0.1 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.7 GO:0008144 drug binding(GO:0008144)
0.1 1.7 GO:0042802 identical protein binding(GO:0042802)
0.1 0.2 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.1 0.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.7 GO:0015297 antiporter activity(GO:0015297)
0.1 0.5 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 0.4 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 0.6 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.3 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.1 0.2 GO:0016208 AMP binding(GO:0016208) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.8 GO:0016896 exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.1 0.2 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 1.0 GO:0016298 lipase activity(GO:0016298)
0.1 0.7 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 0.1 GO:0001026 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.1 0.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 3.2 GO:0016853 isomerase activity(GO:0016853)
0.1 4.8 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.6 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.2 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.0 0.5 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 2.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.6 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 1.3 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0017022 myosin binding(GO:0017022)
0.0 0.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.2 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.1 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.1 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.1 GO:0017171 serine hydrolase activity(GO:0017171)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.5 4.5 PID FOXO PATHWAY FoxO family signaling
1.3 4.0 PID NOTCH PATHWAY Notch signaling pathway
0.8 7.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.4 1.4 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.4 1.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 147.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.2 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
2.4 7.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
1.6 14.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.2 3.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
1.1 2.3 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
1.1 1.1 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.5 1.9 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 0.7 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 2.2 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1 0.6 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 144.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.3 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.1 REACTOME DNA REPAIR Genes involved in DNA Repair