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Results for HSF1

Z-value: 2.17

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Transcription factors associated with HSF1

Gene Symbol Gene ID Gene Info
HSF1
S000003041 Trimeric heat shock transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HSF1YGL073W0.724.0e-05Click!

Activity profile of HSF1 motif

Sorted Z-values of HSF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YBR117C 23.20
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YGR142W 20.55
BTN2
v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YBR072W 18.07
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YDR342C 13.84
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YER103W 13.81
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YPL250C 13.49
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YFL051C 12.61 Putative protein of unknown function; YFL051C is not an essential gene
YBL075C 11.77
SSA3
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YAR050W 11.01
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YJL045W 10.64 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YOR343C 10.14 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YKR097W 9.54
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YDR171W 9.54
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YOR027W 9.40
STI1
Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein
YAR047C 9.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL240C 8.89
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YHR145C 8.79 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL171C 8.19
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YJL116C 7.74
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YCR011C 7.08
ADP1
Putative ATP-dependent permease of the ABC transporter family of proteins
YAL005C 6.64
SSA1
ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YDL180W 6.60 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YLR346C 6.56 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YLL026W 6.53
HSP104
Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YBR101C 6.50
FES1
Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum
YDR258C 6.36
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YOR192C-C 6.03 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YHL040C 5.93
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YPR010C-A 5.81 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YDR070C 5.78
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR102W 5.72
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YMR250W 5.63
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YDR381C-A 5.55 Protein of unknown function, localized to the mitochondrial outer membrane
YMR040W 5.43
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YNR034W 5.37
SOL1
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p
YAL062W 5.36
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YDL169C 5.33
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YOR152C 5.24 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YDR343C 5.22
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YGR065C 5.15
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YBR169C 5.07
SSE2
Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p
YOR192C 5.04
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YKR009C 4.98
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YKL044W 4.87 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR262W 4.83 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
YGL133W 4.62
ITC1
Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1
YNL006W 4.47
LST8
Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
YEL049W 4.45
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YNL194C 4.37 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YOL081W 4.36
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YLR259C 4.36
HSP60
Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YOR298C-A 4.31
MBF1
Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
YDL181W 4.25
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YOR376W 4.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YNL055C 4.12
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YAR035W 4.07
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YDL210W 4.01
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YCR021C 3.97
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YHR211W 3.89
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YPR030W 3.83
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YOR020W-A 3.80 Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR216C 3.80
CPR6
Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YOL128C 3.78
YGK3
Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YDL218W 3.75 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YKL221W 3.74
MCH2
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YNL077W 3.70
APJ1
Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR217W 3.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6
YHL046W-A 3.58 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR046W 3.58
TAH11
DNA replication licensing factor, required for pre-replication complex assembly
YDL085W 3.54
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YIL162W 3.52
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YLR149C 3.50 Putative protein of unknown function; YLR149C is not an essential gene
YMR175W 3.45
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YNL063W 3.45
MTQ1
S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene
YJR045C 3.41
SSC1
Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family
YFR053C 3.41
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YMR053C 3.37
STB2
Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p
YJR078W 3.36
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YIL057C 3.30 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YAR053W 3.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR114C 3.28 Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
YLR307C-A 3.25 Putative protein of unknown function
YHL047C 3.22
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YKL028W 3.10
TFA1
TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YMR081C 3.06
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YKL043W 3.01
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YDL223C 3.00
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YGR211W 2.97
ZPR1
Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p)
YBR056W-A 2.96 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YOR235W 2.92
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YKL141W 2.92
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YDR334W 2.91
SWR1
Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YMR118C 2.91 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YKL171W 2.89 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YGR144W 2.88
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YOR383C 2.88
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YDR250C 2.86 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YFL003C 2.85
MSH4
Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
YDR313C 2.80
PIB1
RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YHR125W 2.77 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR043C 2.76
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YER116C 2.73
SLX8
Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
YLR299W 2.73
ECM38
Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
YBR021W 2.72
FUR4
Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
YAR060C 2.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR378W 2.67 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YNR069C 2.66
BSC5
Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YDR216W 2.64
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YNL007C 2.62
SIS1
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins
YMR196W 2.62 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
YLR164W 2.60 Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YHR210C 2.59 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YOR120W 2.57
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YDL020C 2.52
RPN4
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
YCR005C 2.52
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YPL262W 2.51
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YKR091W 2.51
SRL3
Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate
YFR019W 2.50
FAB1
1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis
YHL008C 2.48 Putative protein of unknown function, does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YOL032W 2.47
OPI10
Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline
YJL199C 2.45
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YOR100C 2.43
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YOR020C 2.41
HSP10
Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES
YAR019C 2.40
CDC15
Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YDR263C 2.40
DIN7
Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination
YAR019W-A 2.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR251W 2.33
PAM1
Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
YLL039C 2.33
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YDL010W 2.33
GRX6
Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX6
YPR007C 2.31
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YHR092C 2.28
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YOL106W 2.27 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDR249C 2.24 Putative protein of unknown function
YOL051W 2.20
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YIL099W 2.18
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YKL220C 2.18
FRE2
Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
YLL029W 2.18
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YOR381W 2.17
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YBR116C 2.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YOR346W 2.14
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YFR057W 2.13 Putative protein of unknown function
YKR039W 2.13
GAP1
General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YOR374W 2.11
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YKR058W 2.11
GLG1
Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin
YDL011C 2.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YPL258C 2.09
THI21
Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
YFL011W 2.07
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YBR250W 2.07
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YGR250C 2.03 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBL048W 2.02 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YDR169C 2.02
STB3
Protein that binds Sin3p in a two-hybrid assay
YDR096W 2.00
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YDR234W 2.00
LYS4
Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YDL012C 1.95 Plasma membrane protein of unknown function; YDL012C is not an essential gene
YPR026W 1.95
ATH1
Acid trehalase required for utilization of extracellular trehalose
YHR212C 1.93 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR214W 1.92
AHA1
Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock
YLL030C 1.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL036W 1.91
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YPL282C 1.89
PAU22
Hypothetical protein
YKR040C 1.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YHL041W 1.85 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YFL050C 1.85
ALR2
Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition
YKL067W 1.83
YNK1
Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YJL100W 1.83
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YDR540C 1.82
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOR308C 1.80
SNU66
Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; has homology to human SART-1 and to an S. pombe protein; snu66 null mutation confers cold-sensitivity but is not lethal at normal growth temperatures
YKL224C 1.76
PAU16
Putative protein of unknown function
YHR212W-A 1.75 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR405W 1.74
MRP20
Mitochondrial ribosomal protein of the large subunit
YAL063C 1.72
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YNL156C 1.72
NSG2
Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins
YCL001W-B 1.69 Putative protein of unknown function; identified by homology
YHR104W 1.69
GRE3
Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway
YOR345C 1.68 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YJR077C 1.66
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YOR228C 1.65 Protein of unknown function, localized to the mitochondrial outer membrane
YGR039W 1.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YDR333C 1.63 Putative protein of unknown function
YBR054W 1.63
YRO2
Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YOR031W 1.62
CRS5
Copper-binding metallothionein, required for wild-type copper resistance
YER033C 1.60
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YLL056C 1.60 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YCR007C 1.59 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YPL224C 1.59
MMT2
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
YBR082C 1.58
UBC4
Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
YDR018C 1.58 Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype
YGR197C 1.57
SNG1
Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance
YGL131C 1.56
SNT2
DNA binding protein with similarity to the S. pombe Snt2 protein
YHR146W 1.56
CRP1
Protein that binds to cruciform DNA structures
YDR034C 1.56
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YHL042W 1.54 Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YDR528W 1.54
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YLL055W 1.54
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YOL055C 1.52
THI20
Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p
YHR202W 1.52 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YPR084W 1.52 Putative protein of unknown function
YBR083W 1.52
TEC1
Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member
YIL101C 1.52
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YBR108W 1.51
AIM3
Protein interacting with Rsv167p; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 16.3 GO:0043335 protein unfolding(GO:0043335)
3.8 34.5 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
3.6 21.7 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
2.7 8.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
2.6 2.6 GO:0071361 positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
2.2 4.4 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
2.0 6.1 GO:0015888 thiamine transport(GO:0015888)
1.9 28.6 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
1.9 15.1 GO:0015891 siderophore transport(GO:0015891)
1.9 24.5 GO:0042026 protein refolding(GO:0042026)
1.9 5.6 GO:0006538 glutamate catabolic process(GO:0006538)
1.4 4.3 GO:0042843 D-xylose catabolic process(GO:0042843)
1.4 4.1 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
1.2 28.4 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
1.1 1.1 GO:0042542 response to hydrogen peroxide(GO:0042542)
1.1 3.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.0 5.1 GO:0051180 vitamin transport(GO:0051180)
1.0 4.0 GO:0015847 putrescine transport(GO:0015847)
1.0 3.8 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
0.9 2.8 GO:0005993 trehalose catabolic process(GO:0005993)
0.9 2.7 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.9 3.6 GO:0042357 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.8 4.2 GO:0071467 cellular response to pH(GO:0071467)
0.8 4.1 GO:0044070 regulation of anion transport(GO:0044070)
0.8 2.3 GO:0006740 NADPH regeneration(GO:0006740)
0.8 3.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.7 19.5 GO:0006885 regulation of pH(GO:0006885)
0.7 4.5 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.7 2.2 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.7 2.8 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.7 0.7 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.7 2.1 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.6 1.9 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.6 5.1 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.6 3.2 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.6 14.6 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.6 1.8 GO:0015693 magnesium ion transport(GO:0015693)
0.6 3.0 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.6 4.5 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.5 6.4 GO:0016925 protein sumoylation(GO:0016925)
0.5 4.7 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.5 1.5 GO:0000101 sulfur amino acid transport(GO:0000101)
0.5 3.5 GO:1902707 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.5 2.0 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.5 1.9 GO:0043462 regulation of ATPase activity(GO:0043462)
0.5 4.8 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.4 2.2 GO:0005980 glycogen catabolic process(GO:0005980)
0.4 2.2 GO:0046185 aldehyde catabolic process(GO:0046185)
0.4 0.8 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.4 2.5 GO:0006020 inositol metabolic process(GO:0006020)
0.4 1.2 GO:0015691 cadmium ion transport(GO:0015691)
0.4 4.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.4 1.2 GO:0044209 AMP salvage(GO:0044209)
0.4 1.2 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.4 0.8 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.4 1.9 GO:0032105 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.4 3.0 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.4 1.9 GO:0009209 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.4 2.5 GO:0006097 glyoxylate cycle(GO:0006097) glyoxylate metabolic process(GO:0046487)
0.3 2.1 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.3 4.7 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.3 1.3 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.3 4.1 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.3 1.6 GO:0000023 maltose metabolic process(GO:0000023)
0.3 1.6 GO:0006828 manganese ion transport(GO:0006828)
0.3 0.9 GO:0032006 regulation of TOR signaling(GO:0032006)
0.3 2.2 GO:0051322 anaphase(GO:0051322)
0.3 0.3 GO:0043270 positive regulation of ion transport(GO:0043270)
0.3 3.8 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.3 1.4 GO:0015793 glycerol transport(GO:0015793)
0.3 0.9 GO:0006108 malate metabolic process(GO:0006108)
0.3 0.9 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 0.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.3 2.8 GO:0000710 meiotic mismatch repair(GO:0000710)
0.3 2.0 GO:0070987 error-free translesion synthesis(GO:0070987)
0.3 0.8 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.2 1.0 GO:0006848 pyruvate transport(GO:0006848)
0.2 1.2 GO:0016562 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.2 2.1 GO:0006829 zinc II ion transport(GO:0006829)
0.2 1.4 GO:0051598 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.2 18.1 GO:0006457 protein folding(GO:0006457)
0.2 1.4 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.2 1.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.2 3.2 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.2 0.4 GO:0090662 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.2 0.2 GO:0051594 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.2 0.6 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 2.3 GO:0006826 iron ion transport(GO:0006826)
0.2 0.6 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.2 1.2 GO:0046777 protein autophosphorylation(GO:0046777)
0.2 0.6 GO:0033499 hexose catabolic process(GO:0019320) galactose catabolic process via UDP-galactose(GO:0033499)
0.2 0.2 GO:0010507 negative regulation of autophagy(GO:0010507)
0.2 1.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 1.1 GO:0000266 mitochondrial fission(GO:0000266)
0.2 2.6 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.2 2.6 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.2 1.3 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.2 3.8 GO:0016579 protein deubiquitination(GO:0016579)
0.2 0.5 GO:0006545 glycine biosynthetic process(GO:0006545)
0.2 0.3 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.2 2.5 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.2 2.0 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.2 0.8 GO:0016241 regulation of macroautophagy(GO:0016241)
0.2 0.8 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.2 1.3 GO:0015893 drug transport(GO:0015893)
0.2 1.0 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.2 0.6 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 5.0 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.2 0.8 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.2 0.3 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 1.0 GO:0006801 superoxide metabolic process(GO:0006801)
0.1 1.0 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.3 GO:2000197 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.1 0.4 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 3.6 GO:0098656 anion transmembrane transport(GO:0098656)
0.1 0.3 GO:0015809 arginine transport(GO:0015809)
0.1 0.8 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.1 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 2.7 GO:0006915 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.1 0.7 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.6 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.1 0.9 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.4 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 0.1 GO:0036251 positive regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0036251) positive regulation of transcription from RNA polymerase II promoter in response to increased salt(GO:0061404) regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
0.1 0.9 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.6 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 0.1 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 0.2 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.1 1.0 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.1 0.3 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.1 0.5 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.5 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 0.3 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 1.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 0.2 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.1 0.3 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 0.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.1 GO:0060631 regulation of meiosis I(GO:0060631)
0.1 0.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.3 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.1 0.4 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 2.6 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.3 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.1 0.6 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.2 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.1 3.8 GO:0009060 aerobic respiration(GO:0009060)
0.1 1.8 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.3 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.1 0.1 GO:0061393 regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061392) positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.1 0.2 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.1 0.6 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.1 0.8 GO:0019740 nitrogen utilization(GO:0019740)
0.1 0.4 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.5 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.3 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 0.3 GO:0010038 response to metal ion(GO:0010038)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.2 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.0 1.8 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.2 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.0 0.4 GO:0006754 ATP biosynthetic process(GO:0006754) hydrogen ion transmembrane transport(GO:1902600)
0.0 0.2 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.7 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.2 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.0 0.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0097502 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0 0.1 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.0 0.1 GO:0046497 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.0 0.1 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.2 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.0 4.1 GO:0007005 mitochondrion organization(GO:0007005)
0.0 0.2 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.6 GO:0022900 electron transport chain(GO:0022900)
0.0 0.1 GO:0055067 monovalent inorganic cation homeostasis(GO:0055067)
0.0 0.4 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.1 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.1 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.0 0.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.1 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.0 0.1 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:0043954 cellular component maintenance(GO:0043954)
0.0 0.1 GO:0042991 transcription factor import into nucleus(GO:0042991)
0.0 0.2 GO:0009968 negative regulation of signal transduction(GO:0009968) negative regulation of signaling(GO:0023057)
0.0 0.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.0 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.0 GO:0045596 negative regulation of cell differentiation(GO:0045596) negative regulation of developmental process(GO:0051093)
0.0 0.1 GO:0007231 osmosensory signaling pathway(GO:0007231)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 10.3 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
1.6 17.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
1.4 4.1 GO:0046930 pore complex(GO:0046930)
1.2 4.6 GO:0008623 CHRAC(GO:0008623)
1.1 4.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.9 4.7 GO:0031931 TORC1 complex(GO:0031931)
0.8 2.3 GO:0005796 Golgi lumen(GO:0005796)
0.8 3.8 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.6 24.6 GO:0005770 late endosome(GO:0005770)
0.5 1.6 GO:0070211 Snt2C complex(GO:0070211)
0.5 4.3 GO:0000795 synaptonemal complex(GO:0000795)
0.4 2.6 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.4 1.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.4 0.8 GO:0032389 MutLalpha complex(GO:0032389)
0.4 1.2 GO:0034099 luminal surveillance complex(GO:0034099)
0.4 1.5 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.4 18.4 GO:0031225 anchored component of membrane(GO:0031225)
0.4 7.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 1.1 GO:0033551 monopolin complex(GO:0033551)
0.2 0.5 GO:0032126 eisosome(GO:0032126)
0.2 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 3.7 GO:0070822 Sin3-type complex(GO:0070822)
0.2 0.6 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 3.0 GO:0000812 Swr1 complex(GO:0000812)
0.2 1.2 GO:0070772 PAS complex(GO:0070772)
0.2 0.5 GO:0005787 signal peptidase complex(GO:0005787)
0.2 2.4 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 0.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 1.8 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.4 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.1 6.3 GO:0010008 endosome membrane(GO:0010008)
0.1 8.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 1.9 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.1 0.3 GO:0033186 CAF-1 complex(GO:0033186)
0.1 1.0 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.3 GO:0038201 TOR complex(GO:0038201)
0.1 0.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 66.0 GO:0005739 mitochondrion(GO:0005739)
0.1 9.9 GO:0000322 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 1.3 GO:0070847 core mediator complex(GO:0070847)
0.1 0.2 GO:0044697 HICS complex(GO:0044697)
0.0 0.7 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.6 GO:0005643 nuclear pore(GO:0005643)
0.0 0.3 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.7 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0070274 RES complex(GO:0070274)
0.0 0.5 GO:0031201 SNARE complex(GO:0031201)
0.0 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.2 GO:0097346 INO80-type complex(GO:0097346)
0.0 0.4 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.0 1.9 GO:0042995 mating projection(GO:0005937) cell projection(GO:0042995)
0.0 0.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.3 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.0 9.8 GO:0031224 intrinsic component of membrane(GO:0031224)
0.0 0.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.0 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 22.3 GO:0005537 mannose binding(GO:0005537)
4.0 16.1 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
3.9 23.2 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
2.3 9.2 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
2.3 20.6 GO:0000149 SNARE binding(GO:0000149)
1.8 7.4 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
1.8 12.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
1.4 11.5 GO:0031072 heat shock protein binding(GO:0031072)
1.4 4.1 GO:0022829 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
1.4 4.1 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
1.3 5.4 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
1.3 4.0 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
1.3 5.2 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
1.3 3.8 GO:0048038 quinone binding(GO:0048038)
1.3 86.3 GO:0051082 unfolded protein binding(GO:0051082)
1.2 3.6 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
1.2 3.5 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.2 3.5 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
1.1 4.4 GO:0004396 hexokinase activity(GO:0004396)
1.1 4.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.0 3.0 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.0 14.3 GO:0015293 symporter activity(GO:0015293)
0.9 2.8 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.9 2.7 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.8 5.6 GO:0005216 ion channel activity(GO:0005216)
0.8 6.3 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.8 7.6 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.7 14.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.7 2.1 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.7 6.1 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.7 2.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.7 2.6 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.6 2.3 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.5 2.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.5 2.0 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.5 2.0 GO:0022821 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.4 1.3 GO:0016289 CoA hydrolase activity(GO:0016289)
0.4 1.3 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.4 1.7 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.4 3.3 GO:0004386 helicase activity(GO:0004386)
0.4 1.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.4 1.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.4 1.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.4 2.1 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 1.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.3 1.7 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.3 4.5 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.3 3.6 GO:0030983 mismatched DNA binding(GO:0030983)
0.3 1.2 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.3 0.6 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.3 2.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 0.5 GO:0022838 substrate-specific channel activity(GO:0022838)
0.3 2.5 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.3 0.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 5.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 3.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 1.0 GO:0045118 azole transporter activity(GO:0045118)
0.2 1.9 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 1.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.2 2.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.2 1.3 GO:0051213 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) dioxygenase activity(GO:0051213)
0.2 0.8 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.2 0.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 4.6 GO:0003713 transcription coactivator activity(GO:0003713)
0.2 2.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.2 1.0 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 1.2 GO:0072509 divalent inorganic cation transmembrane transporter activity(GO:0072509)
0.2 1.2 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.2 4.0 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.2 3.4 GO:0008276 protein methyltransferase activity(GO:0008276)
0.2 0.8 GO:0008198 ferrous iron binding(GO:0008198)
0.1 5.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.5 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.4 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 1.5 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 0.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.5 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.1 0.3 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 0.9 GO:0031386 protein tag(GO:0031386)
0.1 0.3 GO:0032183 SUMO binding(GO:0032183)
0.1 0.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 1.0 GO:0051087 chaperone binding(GO:0051087)
0.1 0.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.0 GO:0005507 copper ion binding(GO:0005507)
0.1 0.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.2 GO:0005536 G-protein coupled receptor activity(GO:0004930) glucose binding(GO:0005536)
0.1 0.3 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.1 0.5 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 0.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.3 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.7 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.2 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.4 GO:0032947 protein complex scaffold(GO:0032947)
0.1 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.4 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.8 GO:0046873 metal ion transmembrane transporter activity(GO:0046873)
0.0 0.1 GO:0072341 vitamin binding(GO:0019842) modified amino acid binding(GO:0072341)
0.0 0.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.1 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.3 GO:0015238 drug transmembrane transporter activity(GO:0015238) drug transporter activity(GO:0090484)
0.0 1.8 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.2 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.0 0.3 GO:0060089 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.0 0.3 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 1.1 GO:0032182 ubiquitin-like protein binding(GO:0032182) ubiquitin binding(GO:0043130)
0.0 0.6 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.3 GO:0008320 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.0 0.9 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.0 0.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.4 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 2.9 GO:0016887 ATPase activity(GO:0016887)
0.0 0.2 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.3 GO:0050661 NADP binding(GO:0050661)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.5 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.6 1.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.3 0.9 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.3 1.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.3 1.1 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.2 0.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 106.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 9.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.7 2.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.6 1.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.5 1.1 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.5 1.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.4 3.7 REACTOME MEIOSIS Genes involved in Meiosis
0.4 1.2 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.2 0.2 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.2 1.8 REACTOME DNA REPAIR Genes involved in DNA Repair
0.2 0.4 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.1 106.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.3 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation