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Results for LEU3

Z-value: 2.15

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Transcription factors associated with LEU3

Gene Symbol Gene ID Gene Info
LEU3
S000004443 Zinc-knuckle transcription factor, repressor and activator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LEU3YLR451W-0.242.3e-01Click!

Activity profile of LEU3 motif

Sorted Z-values of LEU3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 21.69
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YKL096W-A 20.86
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YFR056C 18.97 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YER131W 18.14
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YKL120W 15.16
OAC1
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YKR092C 14.13
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YDR033W 13.95
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YLL045C 12.90
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YOR376W-A 10.92 Putative protein of unknown function; identified by fungal homology and RT-PCR
YGL157W 10.42 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YOL086C 10.34
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YER073W 10.28
ALD5
Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YDR345C 9.98
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YDR344C 9.52 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL009C 9.14
LEU1
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YMR108W 9.05
ILV2
Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YHR094C 8.92
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YOR315W 8.78
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YOR375C 8.54
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YHR208W 8.42
BAT1
Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
YLR355C 8.40
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YMR290C 8.16
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YGR138C 8.09
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YLR154C 8.01
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YMR290W-A 7.99 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YBR092C 7.80
PHO3
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YFL015W-A 7.42 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL015C 7.39 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YJL136C 7.21
RPS21B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YML026C 7.05
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YDR044W 6.96
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YGR108W 6.94
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YBR032W 6.94 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YER074W 6.93
RPS24A
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YER102W 6.92
RPS8B
Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YDL241W 6.90 Putative protein of unknown function; YDL241W is not an essential gene
YLR110C 6.81
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YLR154W-B 6.53 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YER146W 6.51
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YGL201C 6.46
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YGR020C 6.46
VMA7
Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YOR108W 6.39
LEU9
Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YPR157W 6.38 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YER091C 6.37
MET6
Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YDL055C 6.32
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YER130C 6.31 Hypothetical protein
YLR154W-A 6.31 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YOR226C 6.27
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YFL022C 6.24
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YOR273C 6.08
TPO4
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YKL110C 6.05
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YAL038W 5.76
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YEL040W 5.74
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YMR083W 5.69
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YPL177C 5.63
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YGR140W 5.62
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YNL118C 5.59
DCP2
Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family
YKR093W 5.46
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YOR272W 5.45
YTM1
Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YGR139W 5.34 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL056W 5.33
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YDL023C 5.29 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YDR098C 5.28
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YPR074C 5.19
TKL1
Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YIL009W 5.11
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YBL029W 4.99 Non-essential protein of unknown function
YGL039W 4.95 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YLR314C 4.85
CDC3
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YOR101W 4.82
RAS1
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YLR328W 4.78
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YCL063W 4.68
VAC17
Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YDR144C 4.67
MKC7
GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YNL301C 4.60
RPL18B
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YOL085C 4.57 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YDL211C 4.52 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YDL022W 4.52
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YHR128W 4.50
FUR1
Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YOR047C 4.47
STD1
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YPL112C 4.45
PEX25
Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YGL029W 4.43
CGR1
Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
YGL076C 4.37
RPL7A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YDR531W 4.36 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YGR151C 4.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YOR342C 4.26 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YIL009C-A 4.23
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YOR271C 4.14
FSF1
Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YFR054C 4.13 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER137C 4.09 Putative protein of unknown function
YIL133C 4.09
RPL16A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YMR246W 4.06
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YIL118W 4.03
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YHR007C 4.01
ERG11
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YOL101C 3.97
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YPL160W 3.93
CDC60
Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
YER001W 3.89
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YMR049C 3.87
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YOR074C 3.86
CDC21
Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YCL064C 3.78
CHA1
Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YKL218C 3.78
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YKR075C 3.77 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YEL054C 3.73
RPL12A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YDL022C-A 3.71 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YPR148C 3.63 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YNL300W 3.60 Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YOR274W 3.58
MOD5
Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms
YOR073W-A 3.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR
YDR158W 3.55
HOM2
Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YKL081W 3.53
TEF4
Translation elongation factor EF-1 gamma
YGR157W 3.51
CHO2
Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YOR029W 3.50 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YFL016C 3.50
MDJ1
Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YDL228C 3.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1
YGL040C 3.45
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YLR300W 3.45
EXG1
Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YEL001C 3.45
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YML063W 3.34
RPS1B
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YCL018W 3.31
LEU2
Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YDR133C 3.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YOR028C 3.27
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YLR154W-C 3.27
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YNL178W 3.27
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YBR121C 3.23
GRS1
Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
YNL065W 3.20
AQR1
Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YCL024W 3.17
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YBR118W 3.06
TEF2
Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YPL183C 3.04
RTT10
Cytoplasmic protein with a role in regulation of Ty1 transposition
YOR314W 3.02 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL128C 3.00
TBF1
Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation
YHR005C-A 2.99
MRS11
Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YOR092W 2.96
ECM3
Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation
YMR082C 2.93 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL131W 2.90
TOM22
Component of the TOM (translocase of outer membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between the TOM and TIM complexes
YMR003W 2.88
AIM34
Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YBR096W 2.88 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER
YER036C 2.87
ARB1
ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YLR349W 2.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YOR310C 2.80
NOP58
Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YJR016C 2.77
ILV3
Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
YKR038C 2.76
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YLR348C 2.76
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YOR313C 2.76
SPS4
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YCR072C 2.75
RSA4
WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
YNL162W 2.75
RPL42A
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein
YCL023C 2.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YIL051C 2.69
MMF1
Mitochondrial protein involved in maintenance of the mitochondrial genome
YKL051W 2.67
SFK1
Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YBR210W 2.66
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YDR465C 2.66
RMT2
Arginine methyltransferase; ribosomal protein L12 is a substrate
YHR063C 2.65
PAN5
2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
YKL097C 2.63 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YNL090W 2.63
RHO2
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YDR276C 2.61
PMP3
Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YML073C 2.58
RPL6A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
YHR216W 2.58
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YIL121W 2.54
QDR2
Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake
YLR206W 2.52
ENT2
Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YOR179C 2.51
SYC1
Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs
YPL014W 2.48 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YKL165C 2.41
MCD4
Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YPL249C-A 2.38
RPL36B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YCR018C 2.37
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YIR021W 2.35
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YHR063W-A 2.35 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR047C 2.32
AAP1
Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
YMR015C 2.31
ERG5
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YHR181W 2.28
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YLL043W 2.27
FPS1
Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
YNL327W 2.26
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YDL078C 2.21
MDH3
Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
YPL178W 2.17
CBC2
Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YNL289W 2.17
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YDL047W 2.16
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YGR034W 2.15
RPL26B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YBR069C 2.14
TAT1
Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance
YMR208W 2.13
ERG12
Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YPR074W-A 2.13 Hypothetical protein identified by homology
YKL052C 2.11
ASK1
Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
YDR279W 2.09
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YDR226W 2.08
ADK1
Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence
YLR325C 2.08
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YMR037C 2.08
MSN2
Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YOR340C 2.06
RPA43
RNA polymerase I subunit A43
YKL009W 2.02
MRT4
Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YOL092W 2.01 Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W; deletion mutant has no detectable phenotype
YGR279C 2.00
SCW4
Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YDR099W 2.00
BMH2
14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YGR176W 1.98 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR271C-A 1.97
EFG1
Protein of unknown function; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YOL012C 1.97
HTZ1
Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YML123C 1.96
PHO84
High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YKL209C 1.94
STE6
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YER012W 1.94
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YGL145W 1.93
TIP20
Peripheral membrane protein required for fusion of COPI vesicles with the ER, prohibits back-fusion of COPII vesicles with the ER, may act as a sensor for vesicles at the ER membrane; interacts with Sec20p
YER117W 1.92
RPL23B
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YMR251W-A 1.92
HOR7
Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor
YDR157W 1.87 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL034C 1.86 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR130C 1.86
ORT1
Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
YOL077C 1.85
BRX1
Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
YOR107W 1.84
RGS2
Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p

Network of associatons between targets according to the STRING database.

First level regulatory network of LEU3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 22.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
5.1 15.2 GO:0008272 sulfate transport(GO:0008272) C4-dicarboxylate transport(GO:0015740)
4.5 26.7 GO:0009099 valine biosynthetic process(GO:0009099)
4.2 16.7 GO:0000296 spermine transport(GO:0000296)
3.7 18.4 GO:0009098 leucine biosynthetic process(GO:0009098)
3.3 9.9 GO:0019413 acetate biosynthetic process(GO:0019413)
2.8 8.5 GO:0019676 ammonia assimilation cycle(GO:0019676)
2.1 6.3 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
2.1 8.3 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
2.1 6.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
2.0 20.3 GO:0006116 NADH oxidation(GO:0006116)
2.0 9.9 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
1.9 7.6 GO:0007157 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
1.9 3.8 GO:0006567 threonine catabolic process(GO:0006567)
1.9 5.6 GO:0035955 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
1.8 29.5 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
1.6 11.3 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
1.6 6.2 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082)
1.5 4.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
1.5 4.5 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
1.4 10.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
1.4 5.5 GO:0042938 dipeptide transport(GO:0042938)
1.3 3.9 GO:0032006 regulation of TOR signaling(GO:0032006)
1.3 3.9 GO:0009202 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
1.2 4.7 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
1.1 4.5 GO:0010138 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
1.1 5.6 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
1.1 27.9 GO:0006885 regulation of pH(GO:0006885)
1.0 13.6 GO:0000921 septin ring assembly(GO:0000921)
1.0 4.0 GO:0090337 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
1.0 6.8 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.9 1.8 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.9 2.7 GO:1900062 regulation of cell aging(GO:0090342) regulation of replicative cell aging(GO:1900062)
0.9 2.7 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.9 2.6 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.9 3.4 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.8 5.7 GO:0006855 drug transmembrane transport(GO:0006855)
0.8 7.5 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.7 3.0 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015) negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.7 2.8 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.7 2.7 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.7 2.0 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.6 3.9 GO:0006491 N-glycan processing(GO:0006491)
0.6 5.8 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.6 0.6 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.6 1.8 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.6 4.9 GO:0015758 glucose transport(GO:0015758)
0.6 1.8 GO:0046083 purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083)
0.6 14.8 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.6 79.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.6 2.3 GO:0015867 ATP transport(GO:0015867)
0.5 4.9 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.5 1.6 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.5 1.5 GO:0018206 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.5 1.5 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.5 3.8 GO:0051318 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318)
0.5 0.9 GO:0006571 tyrosine biosynthetic process(GO:0006571) L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.5 0.9 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.5 2.3 GO:0006734 NADH metabolic process(GO:0006734)
0.5 6.0 GO:0007120 axial cellular bud site selection(GO:0007120)
0.5 1.8 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.4 3.6 GO:0016559 peroxisome fission(GO:0016559)
0.4 2.7 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.4 6.2 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.4 6.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.4 2.1 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.4 6.6 GO:0000011 vacuole inheritance(GO:0000011)
0.4 2.4 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.4 1.2 GO:0030541 plasmid partitioning(GO:0030541)
0.4 2.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.4 1.5 GO:0007535 donor selection(GO:0007535)
0.4 0.7 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.4 3.3 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.4 1.8 GO:0042435 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.4 1.1 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.4 3.6 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.4 1.1 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.3 6.6 GO:0009086 methionine biosynthetic process(GO:0009086)
0.3 8.7 GO:0016129 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.3 4.1 GO:0032508 DNA duplex unwinding(GO:0032508)
0.3 2.7 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.3 2.0 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.3 2.7 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.3 3.0 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.3 2.9 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.3 0.9 GO:1900436 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.3 6.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 2.4 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.3 1.2 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.3 2.3 GO:0015833 peptide transport(GO:0015833)
0.3 0.3 GO:0071482 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.3 2.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 2.6 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.3 13.2 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.3 3.0 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.3 1.3 GO:0022610 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.3 0.5 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.3 9.2 GO:0006414 translational elongation(GO:0006414)
0.3 1.0 GO:0030497 fatty acid elongation(GO:0030497)
0.2 4.4 GO:0009267 cellular response to starvation(GO:0009267)
0.2 1.0 GO:0046037 GMP metabolic process(GO:0046037)
0.2 3.1 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.2 2.6 GO:0007009 plasma membrane organization(GO:0007009)
0.2 3.5 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.2 4.1 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.2 0.9 GO:0006814 sodium ion transport(GO:0006814)
0.2 0.4 GO:0016114 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.2 2.0 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.2 1.7 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.2 1.1 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.2 28.9 GO:0006364 rRNA processing(GO:0006364)
0.2 3.7 GO:0042723 thiamine-containing compound metabolic process(GO:0042723)
0.2 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.2 0.6 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.2 0.8 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.2 0.6 GO:0043902 starch metabolic process(GO:0005982) starch catabolic process(GO:0005983) regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter(GO:0035956) positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0035957) positive regulation of multi-organism process(GO:0043902) regulation of starch catabolic process(GO:2000881) positive regulation of starch catabolic process(GO:2000883) regulation of starch metabolic process(GO:2000904) positive regulation of starch metabolic process(GO:2000906)
0.2 3.1 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.2 0.9 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.2 0.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 2.0 GO:0006526 arginine biosynthetic process(GO:0006526)
0.2 0.2 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.2 1.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.2 0.2 GO:0006952 defense response(GO:0006952)
0.2 0.5 GO:0048313 Golgi inheritance(GO:0048313)
0.2 0.3 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.2 4.8 GO:0009135 purine nucleoside diphosphate metabolic process(GO:0009135) purine ribonucleoside diphosphate metabolic process(GO:0009179) ribonucleoside diphosphate metabolic process(GO:0009185) ADP metabolic process(GO:0046031)
0.2 2.6 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 3.4 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.2 1.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 0.8 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 0.5 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.2 0.5 GO:0015804 sulfur amino acid transport(GO:0000101) neutral amino acid transport(GO:0015804)
0.2 2.1 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 0.6 GO:0006720 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.1 0.4 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.1 15.1 GO:0006913 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.1 0.9 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.1 0.6 GO:0000087 mitotic M phase(GO:0000087) M phase(GO:0000279)
0.1 2.4 GO:0006614 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.6 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 6.9 GO:0008033 tRNA processing(GO:0008033)
0.1 0.8 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.1 1.0 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 2.7 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 0.4 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.1 8.5 GO:0030036 actin cytoskeleton organization(GO:0030036)
0.1 0.1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.1 0.9 GO:0015677 copper ion import(GO:0015677)
0.1 0.6 GO:0035268 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.1 3.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.6 GO:0031134 sister chromatid biorientation(GO:0031134)
0.1 0.2 GO:0015865 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.1 1.3 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 0.8 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.1 0.2 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.1 0.7 GO:0046351 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 0.6 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 0.2 GO:0043471 regulation of carbohydrate catabolic process(GO:0043470) regulation of cellular carbohydrate catabolic process(GO:0043471)
0.1 1.0 GO:0051050 positive regulation of transport(GO:0051050)
0.1 0.7 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 0.3 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 0.3 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.1 1.3 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 1.6 GO:0000077 DNA damage checkpoint(GO:0000077)
0.1 0.4 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.7 GO:0006272 leading strand elongation(GO:0006272)
0.1 0.8 GO:0045047 protein targeting to ER(GO:0045047)
0.1 0.8 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 0.6 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.7 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 0.2 GO:0048478 replication fork protection(GO:0048478)
0.0 0.3 GO:0016233 telomere capping(GO:0016233)
0.0 0.6 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 0.1 GO:0051055 negative regulation of lipid biosynthetic process(GO:0051055)
0.0 0.1 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.2 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620) cellular response to topologically incorrect protein(GO:0035967)
0.0 0.2 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.2 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.4 GO:0007105 cellular bud site selection(GO:0000282) cytokinesis, site selection(GO:0007105) mitotic cytokinesis, site selection(GO:1902408)
0.0 0.1 GO:0051666 actin cortical patch localization(GO:0051666)
0.0 0.3 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.3 GO:0006887 exocytosis(GO:0006887)
0.0 0.1 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.0 0.2 GO:0018410 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.0 0.3 GO:0042559 folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound biosynthetic process(GO:0042559)
0.0 0.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.5 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 0.2 GO:0072507 cellular divalent inorganic cation homeostasis(GO:0072503) divalent inorganic cation homeostasis(GO:0072507)
0.0 0.0 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.0 1.9 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.3 GO:0043038 tRNA aminoacylation for protein translation(GO:0006418) amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)
0.0 0.2 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.1 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.1 GO:0006816 calcium ion transport(GO:0006816)
0.0 0.3 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0 0.1 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.1 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.0 0.1 GO:0016925 protein sumoylation(GO:0016925)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
3.1 9.3 GO:0070545 PeBoW complex(GO:0070545)
1.9 7.8 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
1.6 4.9 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
1.4 5.6 GO:0031518 CBF3 complex(GO:0031518)
1.3 6.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.2 4.8 GO:0032160 septin filament array(GO:0032160)
1.1 5.7 GO:0000144 cellular bud neck septin ring(GO:0000144)
1.1 6.6 GO:0042555 MCM complex(GO:0042555)
1.1 3.2 GO:0030428 cell septum(GO:0030428)
1.1 64.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.0 6.9 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.9 7.1 GO:0005688 U6 snRNP(GO:0005688)
0.7 2.2 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.7 2.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.7 57.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.6 1.9 GO:0070939 Dsl1p complex(GO:0070939)
0.6 3.2 GO:0000399 cellular bud neck septin structure(GO:0000399) cleavage apparatus septin structure(GO:0032161)
0.6 3.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.6 4.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.5 1.6 GO:0030896 checkpoint clamp complex(GO:0030896)
0.5 8.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 3.3 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.5 1.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.4 6.2 GO:0000786 nucleosome(GO:0000786)
0.4 2.2 GO:0034518 RNA cap binding complex(GO:0034518)
0.4 1.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.4 1.7 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.4 0.8 GO:0044391 ribosomal subunit(GO:0044391)
0.4 17.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.4 2.9 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.4 2.1 GO:0034448 EGO complex(GO:0034448)
0.4 2.8 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.4 1.6 GO:0005797 Golgi medial cisterna(GO:0005797)
0.4 1.5 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.4 1.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.3 1.3 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.3 11.9 GO:0005576 extracellular region(GO:0005576)
0.3 4.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.3 15.2 GO:0031225 anchored component of membrane(GO:0031225)
0.3 4.5 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.3 2.1 GO:0072686 mitotic spindle(GO:0072686)
0.3 0.8 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.3 2.0 GO:0033101 cellular bud membrane(GO:0033101)
0.2 6.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 0.7 GO:0000814 ESCRT II complex(GO:0000814)
0.2 0.7 GO:0001400 mating projection base(GO:0001400)
0.2 0.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 0.7 GO:0042788 polysomal ribosome(GO:0042788)
0.2 4.1 GO:0016586 RSC complex(GO:0016586)
0.2 1.3 GO:0000133 polarisome(GO:0000133)
0.2 2.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 9.5 GO:0044445 cytosolic part(GO:0044445)
0.2 0.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 1.5 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.2 4.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 35.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 1.1 GO:0005871 kinesin complex(GO:0005871)
0.2 0.7 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.2 1.0 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.2 5.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.2 1.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.9 GO:0005884 actin filament(GO:0005884)
0.1 0.6 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.7 GO:0005663 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.1 0.4 GO:0070823 HDA1 complex(GO:0070823)
0.1 25.2 GO:0005730 nucleolus(GO:0005730)
0.1 2.1 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 20.2 GO:0005933 cellular bud(GO:0005933)
0.1 0.8 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.1 GO:0005880 nuclear microtubule(GO:0005880)
0.1 0.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.8 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 4.0 GO:0005811 lipid particle(GO:0005811)
0.1 0.8 GO:0030125 clathrin vesicle coat(GO:0030125)
0.1 1.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 1.7 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.1 1.2 GO:0034399 nuclear periphery(GO:0034399)
0.1 0.4 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.6 GO:0000136 alpha-1,6-mannosyltransferase complex(GO:0000136)
0.1 0.5 GO:0044453 nuclear membrane part(GO:0044453)
0.1 0.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.2 GO:0097196 Shu complex(GO:0097196)
0.1 17.5 GO:0005886 plasma membrane(GO:0005886)
0.1 0.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 2.0 GO:0030863 cortical cytoskeleton(GO:0030863) cortical actin cytoskeleton(GO:0030864)
0.1 4.8 GO:0005768 endosome(GO:0005768)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.2 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.0 2.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.1 GO:0032116 SMC loading complex(GO:0032116)
0.0 8.6 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.1 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.2 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.7 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.2 GO:0031298 replication fork protection complex(GO:0031298)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.2 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
4.2 16.7 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
2.7 16.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
2.7 16.0 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
2.7 10.6 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
2.5 10.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
2.5 9.9 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
2.1 8.5 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
2.1 6.3 GO:0070568 guanylyltransferase activity(GO:0070568)
2.1 6.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
1.9 1.9 GO:0015440 peptide-transporting ATPase activity(GO:0015440) peptide transmembrane transporter activity(GO:1904680)
1.9 7.6 GO:0016841 ammonia-lyase activity(GO:0016841)
1.9 22.7 GO:0005199 structural constituent of cell wall(GO:0005199)
1.7 7.0 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.6 6.5 GO:0009378 four-way junction helicase activity(GO:0009378)
1.5 4.6 GO:0019003 GDP binding(GO:0019003)
1.5 9.0 GO:0003993 acid phosphatase activity(GO:0003993)
1.5 5.9 GO:0008172 S-methyltransferase activity(GO:0008172)
1.4 8.4 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.3 3.9 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
1.1 5.6 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
1.1 3.2 GO:0072341 modified amino acid binding(GO:0072341)
1.0 2.9 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
1.0 5.8 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.0 5.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.9 2.7 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.9 3.4 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.9 2.6 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.8 8.4 GO:0005216 ion channel activity(GO:0005216)
0.8 3.9 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.7 2.2 GO:0000339 RNA cap binding(GO:0000339)
0.7 5.6 GO:0019237 centromeric DNA binding(GO:0019237)
0.7 3.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.7 2.0 GO:0051219 phosphoprotein binding(GO:0051219)
0.6 1.9 GO:0016504 peptidase activator activity(GO:0016504)
0.6 1.9 GO:0008097 5S rRNA binding(GO:0008097)
0.6 4.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.6 2.4 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.6 6.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.6 5.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.6 123.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 5.5 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.5 9.0 GO:0050661 NADP binding(GO:0050661)
0.5 2.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.5 1.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.5 2.9 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.5 1.8 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.4 1.8 GO:0004622 lysophospholipase activity(GO:0004622)
0.4 3.0 GO:0019201 nucleotide kinase activity(GO:0019201)
0.4 4.7 GO:0043495 protein anchor(GO:0043495)
0.4 4.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.4 4.7 GO:0015266 protein channel activity(GO:0015266)
0.4 4.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 2.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 1.0 GO:0009922 fatty acid elongase activity(GO:0009922)
0.3 4.8 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.3 4.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.3 3.3 GO:0030276 clathrin binding(GO:0030276)
0.3 11.3 GO:0051536 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.3 6.1 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.3 19.1 GO:0003924 GTPase activity(GO:0003924)
0.3 0.9 GO:0042973 beta-glucosidase activity(GO:0008422) glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.3 4.9 GO:0042803 protein homodimerization activity(GO:0042803)
0.3 3.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 1.8 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.3 4.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.3 8.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.3 6.0 GO:0019901 protein kinase binding(GO:0019901)
0.3 0.8 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.3 1.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.3 1.3 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.2 5.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 1.0 GO:0005471 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.2 0.7 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.2 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 1.2 GO:0004707 MAP kinase activity(GO:0004707)
0.2 0.7 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.2 1.1 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.2 0.7 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.2 2.4 GO:0004177 aminopeptidase activity(GO:0004177)
0.2 6.1 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 0.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 2.9 GO:0001671 ATPase activator activity(GO:0001671)
0.2 6.6 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.2 2.1 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.2 0.8 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.2 1.0 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.2 0.7 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 0.9 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 4.0 GO:0008170 N-methyltransferase activity(GO:0008170)
0.2 0.8 GO:0000146 microfilament motor activity(GO:0000146)
0.2 1.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 6.0 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 0.5 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.2 0.6 GO:0008252 nucleotidase activity(GO:0008252)
0.2 2.0 GO:0019843 rRNA binding(GO:0019843)
0.2 1.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 1.4 GO:0000049 tRNA binding(GO:0000049)
0.1 0.3 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 3.3 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.9 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 5.0 GO:0008168 methyltransferase activity(GO:0008168)
0.1 0.5 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 4.7 GO:0000287 magnesium ion binding(GO:0000287)
0.1 0.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 2.3 GO:0008017 microtubule binding(GO:0008017)
0.1 3.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.6 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.6 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.9 GO:0019239 deaminase activity(GO:0019239)
0.1 0.5 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.9 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 1.2 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.2 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 0.2 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)
0.1 0.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 0.6 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.1 0.8 GO:0045182 translation regulator activity(GO:0045182)
0.1 1.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 1.0 GO:0015616 DNA translocase activity(GO:0015616)
0.1 1.5 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 0.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.7 GO:0043022 ribosome binding(GO:0043022)
0.1 0.5 GO:0005516 calmodulin binding(GO:0005516)
0.1 2.2 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.9 GO:0016866 intramolecular transferase activity(GO:0016866)
0.1 0.2 GO:0004312 fatty acid synthase activity(GO:0004312)
0.1 12.4 GO:0003723 RNA binding(GO:0003723)
0.1 0.4 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.0 0.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:1901618 organic hydroxy compound transmembrane transporter activity(GO:1901618)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0051015 actin filament binding(GO:0051015)
0.0 1.2 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:0016972 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) thiol oxidase activity(GO:0016972)
0.0 0.5 GO:0019001 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.0 0.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.0 0.3 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.2 GO:0000386 first spliceosomal transesterification activity(GO:0000384) second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.4 GO:0016853 isomerase activity(GO:0016853)
0.0 0.0 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.3 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.2 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.2 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 PID SHP2 PATHWAY SHP2 signaling
0.5 1.6 PID ATM PATHWAY ATM pathway
0.4 0.4 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.2 0.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 0.9 PID E2F PATHWAY E2F transcription factor network
0.2 0.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 0.8 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.2 1.0 PID PLK1 PATHWAY PLK1 signaling events
0.1 0.4 PID MYC PATHWAY C-MYC pathway
0.1 0.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 0.7 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR Genes involved in Downstream signaling of activated FGFR
2.0 5.9 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
1.1 4.5 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
1.0 7.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.9 6.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.6 4.3 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.5 7.2 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
0.4 1.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.4 0.8 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.4 1.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 2.6 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.3 1.8 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.2 1.6 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.2 0.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 1.8 REACTOME G2 M CHECKPOINTS Genes involved in G2/M Checkpoints
0.2 1.1 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.2 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.6 REACTOME DNA REPLICATION Genes involved in DNA Replication
0.1 0.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 0.5 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.0 0.4 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.1 REACTOME TRANSLATION Genes involved in Translation