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Results for MBP1

Z-value: 2.64

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Transcription factors associated with MBP1

Gene Symbol Gene ID Gene Info
MBP1
S000002214 Transcription factor involved in cell cycle progression from G1 to S

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MBP1YDL056W0.432.9e-02Click!

Activity profile of MBP1 motif

Sorted Z-values of MBP1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YBL003C 17.18
HTA2
One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YFR055W 16.40
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 15.30 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YBL085W 13.87
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YNL178W 13.76
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YER070W 11.83
RNR1
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YOR315W 11.82
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YIL053W 10.93
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YMR199W 10.80
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YOR073W-A 9.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR
YBL002W 9.51
HTB2
One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YGR140W 8.72
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YDL023C 8.57 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YER001W 8.53
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YLR154C 8.17
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YOR074C 7.77
CDC21
Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YJR094W-A 7.68
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YNL030W 7.59
HHF2
One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YNL301C 7.59
RPL18B
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YMR290W-A 7.58 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YGL147C 7.58
RPL9A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YDL022W 7.50
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YJR145C 7.43
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YCL024W 7.33
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YMR290C 7.16
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YDL003W 7.14
MCD1
Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase
YDL047W 6.87
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YGR138C 6.81
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YLR349W 6.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YGR108W 6.50
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YAR008W 6.49
SEN34
Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
YLR154W-C 6.42
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YKL063C 6.25 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YJL194W 6.24
CDC6
Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p
YJL190C 6.23
RPS22A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YLR348C 6.22
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YLR154W-A 6.17 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YNR009W 6.10
NRM1
Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
YDR507C 6.00
GIN4
Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p
YJL115W 5.97
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YLR300W 5.96
EXG1
Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YCL023C 5.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YGR139W 5.84 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR154W-B 5.80 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YOR313C 5.75
SPS4
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YGL201C 5.69
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YBR088C 5.60
POL30
Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
YOL040C 5.52
RPS15
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YPL177C 5.45
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YPL081W 5.44
RPS9A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins
YDL101C 5.40
DUN1
Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
YOR376W-A 5.39 Putative protein of unknown function; identified by fungal homology and RT-PCR
YDL022C-A 5.35 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YOL039W 5.34
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YER003C 5.32
PMI40
Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YMR144W 5.24 Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YHR154W 5.21
RTT107
Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition
YGL179C 5.17
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YGL076C 4.97
RPL7A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YOR375C 4.91
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YLR049C 4.90 Putative protein of unknown function
YDL055C 4.83
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YEL001C 4.79
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YOR096W 4.62
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YBL063W 4.61
KIP1
Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YOR314W 4.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFR054C 4.60 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR103C 4.48
CDC45
DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
YLR441C 4.45
RPS1A
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
YOR063W 4.44
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YPL090C 4.43
RPS6A
Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YBR081C 4.39
SPT7
Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
YLR150W 4.35
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YPL256C 4.35
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YML088W 4.30
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YMR177W 4.25
MMT1
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YOR254C 4.25
SEC63
Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YCR065W 4.17
HCM1
Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role
YDL164C 4.17
CDC9
DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
YJR009C 4.16
TDH2
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YPL267W 4.15
ACM1
Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins
YHR010W 4.11
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YPR121W 4.10
THI22
Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
YDL192W 4.09
ARF1
ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
YFL034C-A 4.06
RPL22B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein
YPR050C 4.05 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
YJL173C 4.03
RFA3
Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YGL103W 4.03
RPL28
Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
YPL153C 4.03
RAD53
Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
YNL031C 4.01
HHT2
One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YLR032W 4.01
RAD5
DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; contains RING finger domain
YPL075W 4.00
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YJR043C 3.95
POL32
Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YDL048C 3.92
STP4
Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YGR152C 3.90
RSR1
GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
YDL211C 3.87 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YMR006C 3.86
PLB2
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YIL009W 3.85
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YKR038C 3.83
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YJL136C 3.78
RPS21B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YOL086C 3.77
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YKR094C 3.77
RPL40B
Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YMR070W 3.75
MOT3
Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes
YHR123W 3.73
EPT1
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability
YKL110C 3.72
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YKL096W-A 3.72
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YJR006W 3.72
POL31
DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair
YJR010W 3.67
MET3
ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YGL035C 3.60
MIG1
Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YNL231C 3.59
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YDL085C-A 3.59 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YNL102W 3.59
POL1
Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
YOR327C 3.58
SNC2
Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YNL273W 3.54
TOF1
Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
YDR509W 3.53 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR113C 3.45
PDS1
Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei
YBR084W 3.43
MIS1
Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
YGR251W 3.38 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YCR018C 3.37
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YMR142C 3.34
RPL13B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YIL159W 3.32
BNR1
Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
YLR143W 3.32 Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene
YJL181W 3.30 Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis
YDR508C 3.29
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YFL008W 3.26
SMC1
Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
YGL242C 3.24 Putative protein of unknown function; deletion mutant is viable
YMR076C 3.22
PDS5
Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes in an interdependent manner, may function as a protein-protein interaction scaffold
YOL080C 3.20
REX4
Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
YKL209C 3.19
STE6
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YMR011W 3.17
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YHR153C 3.17
SPO16
Protein of unknown function, required for spore formation
YNL090W 3.16
RHO2
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YAR007C 3.16
RFA1
Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YDR279W 3.15
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YPL250W-A 3.13 Identified by fungal homology and RT-PCR
YHR203C 3.10
RPS4B
Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YGR060W 3.10
ERG25
C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YJL122W 3.09
ALB1
Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
YKL062W 3.06
MSN4
Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YJR005C-A 3.05 Putative protein of unknown function, originally identified as a syntenic homolog of an Ashbya gossypii gene
YHR149C 3.03
SKG6
Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YPL019C 3.03
VTC3
Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
YBR252W 3.02
DUT1
dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability
YOL079W 3.02 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YLR372W 2.99
SUR4
Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YNL166C 2.98
BNI5
Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
YJL196C 2.97
ELO1
Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
YJR094C 2.96
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YMR143W 2.96
RPS16A
Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YER118C 2.95
SHO1
Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway
YDR502C 2.94
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YOL017W 2.94
ESC8
Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex
YDL163W 2.92 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase
YMR083W 2.92
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YPR010C 2.89
RPA135
RNA polymerase I subunit A135
YOR115C 2.85
TRS33
One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YOR092W 2.80
ECM3
Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation
YNL024C 2.79 Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene
YKL128C 2.79
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YMR296C 2.79
LCB1
Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YBR106W 2.77
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YJR022W 2.76
LSM8
Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
YLR313C 2.74
SPH1
Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p
YLL021W 2.73
SPA2
Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
YIL127C 2.73 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YIL169C 2.71 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YNL233W 2.71
BNI4
Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
YMR141W-A 2.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C
YKL101W 2.67
HSL1
Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YNR021W 2.65 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene
YML063W 2.64
RPS1B
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YMR277W 2.62
FCP1
Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
YDR510W 2.62
SMT3
Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YGR249W 2.61
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YJR054W 2.60 Vacuolar protein of unknown function; potential Cdc28p substrate
YHR045W 2.60 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YPL062W 2.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YPL254W 2.59
HFI1
Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
YMR194C-A 2.57 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL152C 2.53
GPM1
Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YPR018W 2.53
RLF2
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin
YOR130C 2.52
ORT1
Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
YKR043C 2.51 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YJL187C 2.51
SWE1
Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
YBR126W-A 2.51 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YDR500C 2.49
RPL37B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
YLR321C 2.48
SFH1
Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
YDL103C 2.47
QRI1
UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis
YDR133C 2.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YKR039W 2.45
GAP1
General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YGL177W 2.44 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL042W 2.43
SPC42
Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
YFL015W-A 2.42 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR025W 2.42
RPS11A
Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YBR078W 2.41
ECM33
GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
YPR175W 2.41
DPB2
Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate
YDL219W 2.41
DTD1
D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
YGR090W 2.39
UTP22
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YBR143C 2.38
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YDR278C 2.38 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Network of associatons between targets according to the STRING database.

First level regulatory network of MBP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 16.1 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
4.5 13.6 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
4.0 16.0 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
3.6 10.9 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
3.4 10.2 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
3.1 21.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
2.5 7.5 GO:0035952 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
2.4 4.8 GO:0030541 plasmid partitioning(GO:0030541)
2.1 10.6 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
2.0 40.3 GO:0006334 nucleosome assembly(GO:0006334)
2.0 9.8 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
1.9 11.5 GO:0048478 replication fork protection(GO:0048478)
1.9 7.5 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
1.9 7.4 GO:0030497 fatty acid elongation(GO:0030497)
1.7 7.0 GO:0000296 spermine transport(GO:0000296)
1.7 5.1 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
1.7 15.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.7 3.3 GO:0009219 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate biosynthetic process(GO:0046385)
1.6 4.9 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.6 4.9 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
1.6 6.4 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
1.5 6.2 GO:1902931 negative regulation of alcohol biosynthetic process(GO:1902931)
1.5 16.4 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
1.5 8.9 GO:0006491 N-glycan processing(GO:0006491)
1.5 4.4 GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422)
1.5 5.9 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
1.5 4.4 GO:0060548 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
1.4 14.4 GO:0007076 mitotic chromosome condensation(GO:0007076)
1.4 15.6 GO:0006273 lagging strand elongation(GO:0006273)
1.4 22.5 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
1.3 4.0 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
1.2 2.5 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
1.2 2.4 GO:0006572 tyrosine catabolic process(GO:0006572)
1.1 4.5 GO:0030834 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
1.1 2.2 GO:0015909 long-chain fatty acid transport(GO:0015909)
1.1 3.3 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
1.1 4.3 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
1.1 2.1 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
1.0 11.2 GO:0006817 phosphate ion transport(GO:0006817)
1.0 4.0 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
1.0 9.0 GO:0010695 regulation of spindle pole body separation(GO:0010695)
1.0 6.0 GO:0032508 DNA duplex unwinding(GO:0032508)
0.9 8.4 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.9 3.7 GO:0006657 CDP-choline pathway(GO:0006657)
0.9 1.9 GO:0009847 spore germination(GO:0009847)
0.9 126.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.9 5.5 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.9 2.7 GO:0008105 asymmetric protein localization(GO:0008105)
0.9 1.8 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.9 4.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.8 3.2 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.8 4.0 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.8 2.4 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.8 2.3 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.8 1.5 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.7 0.7 GO:0007232 osmosensory signaling pathway via Sho1 osmosensor(GO:0007232)
0.7 5.9 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.7 3.7 GO:0046656 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.7 1.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.7 2.9 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.7 8.7 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.7 14.4 GO:0007020 microtubule nucleation(GO:0007020) microtubule polymerization(GO:0046785)
0.7 4.9 GO:0045014 negative regulation of transcription from RNA polymerase II promoter by glucose(GO:0000433) negative regulation of transcription by glucose(GO:0045014)
0.7 17.4 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.7 8.3 GO:0010383 cell wall polysaccharide metabolic process(GO:0010383)
0.7 2.6 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.7 2.0 GO:0045128 negative regulation of reciprocal meiotic recombination(GO:0045128)
0.7 2.6 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.7 2.6 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.6 2.5 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.6 3.6 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.6 4.2 GO:0043457 regulation of cellular respiration(GO:0043457)
0.6 1.2 GO:0048211 Golgi vesicle docking(GO:0048211)
0.6 1.2 GO:0006110 regulation of glycolytic process(GO:0006110)
0.6 7.0 GO:0007120 axial cellular bud site selection(GO:0007120)
0.6 1.7 GO:0031382 mating projection assembly(GO:0031382)
0.5 2.2 GO:0050667 transsulfuration(GO:0019346) homocysteine metabolic process(GO:0050667)
0.5 1.6 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.5 2.7 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.5 1.6 GO:0071456 cellular response to hypoxia(GO:0071456)
0.5 4.2 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.5 2.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.5 1.5 GO:0006567 threonine catabolic process(GO:0006567)
0.5 3.0 GO:0010529 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.5 11.0 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.5 2.0 GO:0048313 Golgi inheritance(GO:0048313)
0.5 2.0 GO:0015883 FAD transport(GO:0015883)
0.5 2.0 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.5 1.4 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.5 5.7 GO:0006415 translational termination(GO:0006415)
0.5 0.9 GO:0031292 gene conversion at mating-type locus, DNA double-strand break processing(GO:0031292)
0.5 4.1 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.5 3.2 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.5 0.9 GO:0048194 Golgi vesicle budding(GO:0048194)
0.5 1.8 GO:0072396 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.4 2.2 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.4 4.0 GO:0009395 phospholipid catabolic process(GO:0009395)
0.4 1.3 GO:0043419 urea catabolic process(GO:0043419)
0.4 2.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 4.4 GO:0015833 peptide transport(GO:0015833)
0.4 1.3 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.4 1.3 GO:0001111 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.4 1.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.4 1.2 GO:0044819 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.4 2.8 GO:0016584 nucleosome positioning(GO:0016584)
0.4 3.1 GO:0030261 chromosome condensation(GO:0030261)
0.4 2.0 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.4 1.2 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.4 3.7 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.4 1.8 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.4 3.3 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.4 3.2 GO:0055070 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.3 1.4 GO:0043007 maintenance of rDNA(GO:0043007)
0.3 5.0 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.3 8.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.3 2.6 GO:0006284 base-excision repair(GO:0006284)
0.3 1.3 GO:0017157 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338) regulation of secretion by cell(GO:1903530)
0.3 3.7 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.3 0.6 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.3 1.2 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.3 1.5 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.3 2.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.3 1.8 GO:0009099 valine biosynthetic process(GO:0009099)
0.3 1.5 GO:0042435 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.3 0.9 GO:0007535 donor selection(GO:0007535)
0.3 0.9 GO:0070623 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.3 3.8 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.3 1.7 GO:0034063 stress granule assembly(GO:0034063)
0.3 1.7 GO:0070941 eisosome assembly(GO:0070941)
0.3 0.3 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.3 2.5 GO:0006458 'de novo' protein folding(GO:0006458)
0.3 0.8 GO:0046777 protein autophosphorylation(GO:0046777)
0.3 0.5 GO:0071044 histone mRNA metabolic process(GO:0008334) histone mRNA catabolic process(GO:0071044)
0.3 0.5 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.3 1.0 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.3 2.9 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.3 1.0 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.3 1.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.2 8.9 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.2 1.0 GO:0007157 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.2 1.4 GO:0006901 vesicle coating(GO:0006901)
0.2 5.4 GO:0042255 ribosome assembly(GO:0042255)
0.2 1.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 1.7 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.2 3.0 GO:0006999 nuclear pore organization(GO:0006999)
0.2 0.6 GO:0000733 DNA strand renaturation(GO:0000733)
0.2 1.3 GO:0000755 cytogamy(GO:0000755)
0.2 0.6 GO:0034310 ethanol catabolic process(GO:0006068) acetate biosynthetic process(GO:0019413) primary alcohol catabolic process(GO:0034310)
0.2 2.6 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.2 1.5 GO:0006272 leading strand elongation(GO:0006272)
0.2 0.6 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.2 1.7 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.2 2.9 GO:0030488 tRNA methylation(GO:0030488)
0.2 4.0 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.2 0.8 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 8.1 GO:0007124 pseudohyphal growth(GO:0007124)
0.2 0.9 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 0.5 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.2 0.9 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.2 0.5 GO:0006344 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.2 0.7 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 0.4 GO:0046677 response to antibiotic(GO:0046677)
0.2 3.1 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 1.5 GO:0006526 arginine biosynthetic process(GO:0006526)
0.2 1.5 GO:0042991 transcription factor import into nucleus(GO:0042991)
0.2 0.5 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.2 2.3 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 0.7 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.2 4.6 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.2 0.6 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 0.9 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.2 1.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 0.6 GO:0070828 heterochromatin organization(GO:0070828)
0.1 0.9 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 1.5 GO:0000921 septin ring assembly(GO:0000921)
0.1 1.0 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 1.9 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 1.9 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.1 0.3 GO:2000197 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.1 6.6 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 0.5 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.1 0.3 GO:1901983 regulation of histone acetylation(GO:0035065) regulation of protein acetylation(GO:1901983) regulation of peptidyl-lysine acetylation(GO:2000756)
0.1 17.3 GO:0006364 rRNA processing(GO:0006364)
0.1 0.4 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.3 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 0.5 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.1 2.9 GO:0006885 regulation of pH(GO:0006885)
0.1 5.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 2.3 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 2.2 GO:0000725 recombinational repair(GO:0000725)
0.1 0.4 GO:0051258 protein polymerization(GO:0051258)
0.1 1.3 GO:0000077 DNA damage checkpoint(GO:0000077)
0.1 0.6 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.1 0.2 GO:0031106 septin ring organization(GO:0031106)
0.1 0.6 GO:0071267 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.1 0.7 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.6 GO:0071027 RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.1 0.4 GO:0009306 protein secretion(GO:0009306)
0.1 0.3 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.1 1.6 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.1 0.8 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 2.1 GO:0006400 tRNA modification(GO:0006400)
0.1 0.2 GO:0070893 DNA integration(GO:0015074) transposon integration(GO:0070893)
0.1 0.8 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.1 0.9 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.6 GO:0034982 mitochondrial protein processing(GO:0034982)
0.1 2.7 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 0.2 GO:0051225 spindle assembly(GO:0051225)
0.1 0.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 1.1 GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0000750) signal transduction involved in conjugation with cellular fusion(GO:0032005)
0.1 0.4 GO:0033014 porphyrin-containing compound metabolic process(GO:0006778) porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole metabolic process(GO:0033013) tetrapyrrole biosynthetic process(GO:0033014) heme metabolic process(GO:0042168)
0.1 0.3 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389) positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) regulation of cell cycle G2/M phase transition(GO:1902749) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 0.9 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 0.4 GO:0019365 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.1 4.0 GO:0007015 actin filament organization(GO:0007015)
0.1 0.7 GO:0006972 hyperosmotic response(GO:0006972)
0.1 0.4 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.1 0.6 GO:0051666 actin cortical patch localization(GO:0051666)
0.1 1.4 GO:0040020 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.1 0.2 GO:0045862 positive regulation of proteolysis(GO:0045862)
0.1 0.2 GO:0000389 mRNA branch site recognition(GO:0000348) mRNA 3'-splice site recognition(GO:0000389)
0.1 1.0 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 0.2 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.1 0.2 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.1 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.2 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.1 0.2 GO:2001252 positive regulation of chromosome organization(GO:2001252)
0.1 1.5 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 0.3 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.8 GO:0006379 mRNA cleavage(GO:0006379)
0.1 1.3 GO:0006413 translational initiation(GO:0006413)
0.1 0.3 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.1 1.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.9 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.8 GO:0045047 protein targeting to ER(GO:0045047)
0.0 0.2 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.0 1.3 GO:0046474 glycerophospholipid biosynthetic process(GO:0046474)
0.0 0.3 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.2 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.2 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.3 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.3 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0019932 second-messenger-mediated signaling(GO:0019932)
0.0 0.2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.0 0.0 GO:0035690 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.1 GO:2000241 regulation of reproductive process(GO:2000241)
0.0 0.1 GO:0007029 endoplasmic reticulum organization(GO:0007029)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
3.4 13.6 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
3.2 38.1 GO:0000788 nuclear nucleosome(GO:0000788)
2.8 8.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
2.5 7.6 GO:0005662 DNA replication factor A complex(GO:0005662)
2.5 7.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
2.0 8.1 GO:0031518 CBF3 complex(GO:0031518)
1.6 6.4 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
1.5 6.2 GO:0030907 MBF transcription complex(GO:0030907)
1.4 2.9 GO:0008278 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
1.4 8.4 GO:0042555 MCM complex(GO:0042555)
1.3 82.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.3 5.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.3 20.0 GO:0005940 septin ring(GO:0005940)
1.2 16.1 GO:0031298 replication fork protection complex(GO:0031298)
1.1 3.3 GO:0033186 CAF-1 complex(GO:0033186)
1.1 3.3 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
1.0 5.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.0 1.0 GO:0005822 inner plaque of spindle pole body(GO:0005822)
1.0 5.2 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
1.0 3.1 GO:0044697 HICS complex(GO:0044697)
1.0 3.8 GO:0005797 Golgi medial cisterna(GO:0005797)
1.0 79.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.9 8.7 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.8 4.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.8 4.9 GO:0005871 kinesin complex(GO:0005871)
0.8 3.2 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.8 2.4 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.8 3.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.7 3.0 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.7 2.0 GO:0032301 MutSalpha complex(GO:0032301)
0.7 2.6 GO:0031207 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.6 3.9 GO:0000133 polarisome(GO:0000133)
0.6 3.1 GO:0031391 Elg1 RFC-like complex(GO:0031391)
0.6 3.6 GO:0000796 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.6 4.2 GO:0051233 spindle midzone(GO:0051233)
0.6 2.3 GO:0097255 R2TP complex(GO:0097255)
0.6 1.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.6 9.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 2.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.5 4.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.5 2.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.5 4.2 GO:0005688 U6 snRNP(GO:0005688)
0.5 2.1 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.5 7.5 GO:0005657 replication fork(GO:0005657)
0.5 8.9 GO:0016586 RSC complex(GO:0016586)
0.5 0.5 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.5 2.4 GO:0032545 CURI complex(GO:0032545)
0.5 3.7 GO:0030008 TRAPP complex(GO:0030008)
0.5 1.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.5 7.7 GO:0022626 cytosolic ribosome(GO:0022626)
0.4 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 0.9 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.4 1.3 GO:0030896 checkpoint clamp complex(GO:0030896)
0.4 0.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.4 2.2 GO:0005771 multivesicular body(GO:0005771)
0.4 2.5 GO:0072686 mitotic spindle(GO:0072686)
0.4 4.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.4 6.7 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.4 1.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.3 1.4 GO:0097196 Shu complex(GO:0097196)
0.3 1.4 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.3 1.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 3.6 GO:0030658 transport vesicle membrane(GO:0030658)
0.3 1.2 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.3 1.5 GO:0031262 Ndc80 complex(GO:0031262)
0.3 1.5 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.3 1.2 GO:0030689 Noc complex(GO:0030689)
0.3 13.3 GO:0000131 incipient cellular bud site(GO:0000131)
0.3 0.6 GO:0005824 outer plaque of spindle pole body(GO:0005824)
0.3 10.3 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.3 0.6 GO:0000786 nucleosome(GO:0000786)
0.3 1.7 GO:0032126 eisosome(GO:0032126)
0.3 1.9 GO:0000346 transcription export complex(GO:0000346)
0.3 1.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.3 0.8 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.3 14.7 GO:0030686 90S preribosome(GO:0030686)
0.3 1.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.3 0.8 GO:0070274 RES complex(GO:0070274)
0.3 1.0 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.2 2.0 GO:0017119 Golgi transport complex(GO:0017119)
0.2 23.4 GO:0005935 cellular bud neck(GO:0005935)
0.2 2.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 0.7 GO:0032389 MutLalpha complex(GO:0032389)
0.2 0.7 GO:0005880 polar microtubule(GO:0005827) nuclear microtubule(GO:0005880) tubulin complex(GO:0045298)
0.2 3.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 0.9 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.2 7.7 GO:0005811 lipid particle(GO:0005811)
0.2 0.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.2 1.4 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.2 0.9 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.2 0.2 GO:0030904 retromer complex(GO:0030904)
0.2 0.8 GO:0034044 exomer complex(GO:0034044)
0.2 2.9 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.2 0.5 GO:0070985 TFIIK complex(GO:0070985)
0.2 0.2 GO:0033309 SBF transcription complex(GO:0033309)
0.2 12.3 GO:0000139 Golgi membrane(GO:0000139)
0.2 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 0.6 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.9 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.1 6.6 GO:0005819 spindle(GO:0005819)
0.1 0.9 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.4 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.9 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.6 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.1 0.6 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 0.6 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.3 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 1.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.9 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.3 GO:0000417 HIR complex(GO:0000417)
0.1 0.5 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 0.6 GO:0030897 HOPS complex(GO:0030897)
0.1 0.2 GO:0030428 cell septum(GO:0030428)
0.1 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.1 2.9 GO:0005844 polysome(GO:0005844)
0.1 0.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 6.7 GO:0000785 chromatin(GO:0000785)
0.1 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 4.4 GO:0005794 Golgi apparatus(GO:0005794)
0.1 1.9 GO:0005643 nuclear pore(GO:0005643)
0.1 0.2 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.1 1.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 1.8 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0033176 vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176)
0.0 0.3 GO:0043614 multi-eIF complex(GO:0043614)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0034099 luminal surveillance complex(GO:0034099)
0.0 0.3 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 30.8 GO:0005634 nucleus(GO:0005634)
0.0 0.2 GO:0005934 cellular bud tip(GO:0005934)
0.0 0.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.6 GO:0009378 four-way junction helicase activity(GO:0009378)
2.7 10.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
2.5 7.6 GO:0072341 modified amino acid binding(GO:0072341)
2.5 15.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
2.5 7.4 GO:0009922 fatty acid elongase activity(GO:0009922)
2.4 14.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
2.2 8.9 GO:0008310 3'-5'-exodeoxyribonuclease activity(GO:0008296) single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
1.9 5.6 GO:0003680 AT DNA binding(GO:0003680)
1.7 7.0 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
1.7 8.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.7 8.5 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.6 4.8 GO:0070568 guanylyltransferase activity(GO:0070568)
1.6 6.4 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
1.4 4.2 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.4 5.4 GO:0005034 osmosensor activity(GO:0005034)
1.3 5.3 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.3 4.0 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
1.3 9.1 GO:0019237 centromeric DNA binding(GO:0019237)
1.3 3.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.3 37.6 GO:0046982 protein heterodimerization activity(GO:0046982)
1.2 4.9 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.2 4.7 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
1.2 3.5 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
1.1 4.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
1.1 3.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
1.0 4.2 GO:0004622 lysophospholipase activity(GO:0004622)
1.0 5.2 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
1.0 2.0 GO:0019104 DNA N-glycosylase activity(GO:0019104)
1.0 15.7 GO:0070491 repressing transcription factor binding(GO:0070491)
1.0 2.9 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
1.0 2.9 GO:0004100 chitin synthase activity(GO:0004100)
0.9 23.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.9 3.5 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.8 37.9 GO:0019843 rRNA binding(GO:0019843)
0.8 2.5 GO:0070569 uridylyltransferase activity(GO:0070569)
0.8 3.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.8 6.1 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.7 3.7 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.7 2.1 GO:0016504 peptidase activator activity(GO:0016504)
0.7 2.1 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.7 2.0 GO:0004000 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.6 6.4 GO:0031386 protein tag(GO:0031386)
0.6 4.9 GO:0003777 microtubule motor activity(GO:0003777)
0.6 1.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.6 4.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.6 102.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 2.3 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.5 1.6 GO:0019003 GDP binding(GO:0019003)
0.5 4.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.5 1.1 GO:0000403 Y-form DNA binding(GO:0000403)
0.5 2.7 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.5 2.6 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.5 9.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.5 2.0 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.5 2.9 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.5 12.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 2.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.5 1.4 GO:0032451 demethylase activity(GO:0032451)
0.5 7.5 GO:0015616 DNA translocase activity(GO:0015616)
0.5 2.3 GO:0048256 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.5 1.4 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.4 4.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 1.7 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.4 15.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 1.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.4 4.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 13.2 GO:0042393 histone binding(GO:0042393)
0.4 2.3 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.4 4.3 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.3 1.4 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.3 4.8 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.3 2.0 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 1.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 1.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.3 19.2 GO:0003924 GTPase activity(GO:0003924)
0.3 9.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.3 1.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.3 1.8 GO:0019201 nucleotide kinase activity(GO:0019201)
0.3 0.9 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.3 0.3 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.3 0.3 GO:1904680 peptide transmembrane transporter activity(GO:1904680)
0.3 0.9 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.3 1.7 GO:0015248 sterol transporter activity(GO:0015248)
0.3 0.3 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.3 0.5 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.3 7.6 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.3 1.6 GO:0004312 fatty acid synthase activity(GO:0004312)
0.3 1.0 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.3 5.0 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.2 2.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 0.7 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.2 1.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 4.6 GO:0003684 damaged DNA binding(GO:0003684)
0.2 1.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2 1.1 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.2 20.1 GO:0005198 structural molecule activity(GO:0005198)
0.2 3.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 2.4 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.2 23.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.2 0.6 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2 8.1 GO:0003779 actin binding(GO:0003779)
0.2 6.0 GO:0030674 protein binding, bridging(GO:0030674)
0.2 11.1 GO:0003682 chromatin binding(GO:0003682)
0.2 0.6 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.2 0.6 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.2 1.6 GO:0003724 RNA helicase activity(GO:0003724)
0.2 2.1 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.2 0.9 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 0.4 GO:0000150 recombinase activity(GO:0000150)
0.2 1.3 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.2 0.5 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.2 4.4 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.2 1.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 0.6 GO:0016408 C-acyltransferase activity(GO:0016408)
0.2 0.8 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.2 0.6 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 1.2 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 1.9 GO:0019887 protein kinase regulator activity(GO:0019887)
0.1 0.3 GO:0019901 protein kinase binding(GO:0019901)
0.1 2.0 GO:0019001 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.1 1.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.3 GO:0019207 kinase regulator activity(GO:0019207)
0.1 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.1 0.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.0 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.7 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 1.7 GO:0051087 chaperone binding(GO:0051087)
0.1 9.0 GO:0008289 lipid binding(GO:0008289)
0.1 6.2 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.6 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 4.1 GO:0008168 methyltransferase activity(GO:0008168)
0.1 0.3 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.1 0.6 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.1 GO:0051213 dioxygenase activity(GO:0051213)
0.1 0.5 GO:0000149 SNARE binding(GO:0000149)
0.1 1.3 GO:0015631 tubulin binding(GO:0015631)
0.1 0.3 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.3 GO:0000339 RNA cap binding(GO:0000339)
0.1 6.5 GO:0003690 double-stranded DNA binding(GO:0003690)
0.1 4.7 GO:0016791 phosphatase activity(GO:0016791)
0.1 1.1 GO:0046983 protein dimerization activity(GO:0046983)
0.1 0.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 2.8 GO:0030695 GTPase regulator activity(GO:0030695)
0.1 0.1 GO:0015645 long-chain fatty acid-CoA ligase activity(GO:0004467) fatty acid ligase activity(GO:0015645)
0.1 1.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 0.5 GO:0017069 snRNA binding(GO:0017069)
0.1 0.5 GO:0043566 structure-specific DNA binding(GO:0043566)
0.1 1.4 GO:0008047 enzyme activator activity(GO:0008047)
0.1 0.3 GO:0019239 deaminase activity(GO:0019239)
0.0 0.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.3 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0000049 tRNA binding(GO:0000049)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.3 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.7 GO:0030234 enzyme regulator activity(GO:0030234)
0.0 0.1 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.2 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.2 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.1 PID E2F PATHWAY E2F transcription factor network
1.4 4.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.0 3.0 PID ATM PATHWAY ATM pathway
0.6 1.9 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.6 1.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.5 4.0 PID ATR PATHWAY ATR signaling pathway
0.4 0.9 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.4 0.4 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.4 0.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.3 1.2 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.3 1.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.3 1.3 PID PLK1 PATHWAY PLK1 signaling events
0.2 0.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.2 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
2.8 11.2 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
2.7 21.8 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
1.5 23.8 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
1.4 8.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.4 4.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.6 1.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.6 3.7 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.6 1.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.5 0.5 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.5 0.5 REACTOME INFLUENZA LIFE CYCLE Genes involved in Influenza Life Cycle
0.4 4.4 REACTOME G2 M CHECKPOINTS Genes involved in G2/M Checkpoints
0.4 0.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.4 1.2 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 1.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.3 3.6 REACTOME MITOTIC M M G1 PHASES Genes involved in Mitotic M-M/G1 phases
0.2 1.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 0.2 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.2 0.4 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.2 1.7 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
0.2 0.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 2.0 REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.1 2.5 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 0.4 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.1 0.5 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.0 0.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism