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Results for MIG2

Z-value: 0.78

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Transcription factors associated with MIG2

Gene Symbol Gene ID Gene Info
MIG2
S000003177 Zinc finger transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MIG2YGL209W-0.714.2e-05Click!

Activity profile of MIG2 motif

Sorted Z-values of MIG2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YDR342C 12.14
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YIL162W 6.90
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YGR067C 6.83 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YGR243W 6.72
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFR053C 6.62
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YDR343C 6.32
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YNR073C 5.79 Putative mannitol dehydrogenase
YKL217W 5.53
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YLR327C 5.35
TMA10
Protein of unknown function that associates with ribosomes
YDR536W 4.98
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YHR092C 4.98
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YOR100C 4.43
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YEL070W 4.33
DSF1
Deletion suppressor of mpt5 mutation
YPR184W 4.24
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YMR107W 4.12
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YLR023C 3.94
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YER065C 3.85
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YDR277C 3.68
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YMR081C 3.48
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YFL052W 3.34 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YJR115W 3.28 Putative protein of unknown function
YFR017C 3.21 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YPR030W 3.19
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YNR002C 3.18
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YBR105C 3.14
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YOL052C-A 3.01
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YLR312C 2.88
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YDR178W 2.77
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YGR183C 2.76
QCR9
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YOR343C 2.69 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPL119C 2.61
DBP1
Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs
YML089C 2.60 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YMR272C 2.60
SCS7
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YHR211W 2.54
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YOL154W 2.54
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YER084W 2.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL166W 2.42
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YHL032C 2.42
GUT1
Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
YEL011W 2.36
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YCR010C 2.36
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YLR377C 2.29
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YMR194C-B 2.26 Putative protein of unknown function
YBR033W 2.22
EDS1
Putative zinc cluster protein; YBR033W is not an essential gene
YNR071C 2.15 Putative protein of unknown function
YHR217C 2.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YOR382W 2.07
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YMR105C 2.07
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YKL093W 2.06
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YML042W 2.05
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YIL057C 2.03 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YDL244W 1.96
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YBR297W 1.93
MAL33
MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YDR032C 1.92
PST2
Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML120C 1.90
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YER066W 1.90 Putative protein of unknown function; YER066W is not an essential gene
YDL079C 1.89
MRK1
Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YKL109W 1.88
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YPL201C 1.88
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YGL146C 1.86 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YBR019C 1.86
GAL10
UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
YJR120W 1.84 Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YAL039C 1.84
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YLR004C 1.81
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YNL117W 1.79
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YIL155C 1.78
GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YNL144C 1.77 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YBR230C 1.76
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YFL054C 1.70 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YKR066C 1.68
CCP1
Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YCR091W 1.68
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YLR258W 1.67
GSY2
Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YBR050C 1.64
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YKR097W 1.62
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YPL134C 1.61
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YLR174W 1.56
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YBR051W 1.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YOR383C 1.54
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YPL200W 1.50
CSM4
Protein required for accurate chromosome segregation during meiosis
YDL214C 1.47
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YMR280C 1.43
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YML090W 1.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YGR288W 1.38
MAL13
MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
YHR210C 1.37 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YHR218W 1.37 Helicase-like protein encoded within the telomeric Y' element
YKR067W 1.36
GPT2
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YMR104C 1.36
YPK2
Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YHL021C 1.36
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YNL055C 1.34
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YER004W 1.34
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YDL130W-A 1.32
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YDR516C 1.32
EMI2
Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p
YOL084W 1.31
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YKR102W 1.31
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YCR007C 1.30 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YOR376W 1.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YDR009W 1.29
GAL3
Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
YFL062W 1.25
COS4
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YNL142W 1.25
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YDR247W 1.25
VHS1
Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YKL141W 1.25
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YOR374W 1.22
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YEL074W 1.22 Hypothetical protein
YAL060W 1.22
BDH1
NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
YFL063W 1.21 Dubious open reading frame, based on available experimental and comparative sequence data
YBR132C 1.21
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YNR014W 1.21 Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YER067W 1.21 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YOR178C 1.17
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YLR296W 1.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL033W 1.17
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YPL036W 1.15
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YLR295C 1.14
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YIL055C 1.12 Putative protein of unknown function
YAL054C 1.12
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YPL230W 1.11
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YFL011W 1.11
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YFL053W 1.11
DAK2
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YPR196W 1.09 Putative maltose activator
YJR159W 1.09
SOR1
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YNL125C 1.09
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YBR021W 1.09
FUR4
Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
YFR015C 1.08
GSY1
Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YCL001W-B 1.07 Putative protein of unknown function; identified by homology
YDR010C 1.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR001W 1.06
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YBR020W 1.06
GAL1
Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p
YJR154W 1.04 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YFL064C 1.04 Putative protein of unknown function
YCL054W 1.04
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YFL055W 1.04
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YIL125W 1.00
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YEL075C 0.99 Putative protein of unknown function
YPL156C 0.98
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YOR134W 0.96
BAG7
Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p
YPL040C 0.96
ISM1
Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
YOR020W-A 0.95 Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFL036W 0.94
RPO41
Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YCR005C 0.94
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YNL196C 0.94
SLZ1
Sporulation-specific protein with a leucine zipper motif
YDR234W 0.94
LYS4
Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YOL051W 0.93
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YPR013C 0.93 Putative zinc finger protein; YPR013C is not an essential gene
YPR160W 0.92
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YCR073W-A 0.92
SOL2
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p
YER188C-A 0.91 Putative protein of unknown function
YOR338W 0.90 Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen
YER039C-A 0.89 Putative protein of unknown function; YER039C-A is not an essential gene
YGR254W 0.89
ENO1
Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YLL039C 0.88
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YER150W 0.88
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YIL024C 0.87 Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
YML091C 0.87
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YKL031W 0.87 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YOR120W 0.86
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YDL245C 0.85
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YLR149C 0.84 Putative protein of unknown function; YLR149C is not an essential gene
YDL194W 0.83
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YMR175W 0.82
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YPR150W 0.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YMR195W 0.81
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YJL043W 0.81 Putative protein of unknown function; YJL043W is a non-essential gene
YBL094C 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
YNL336W 0.79
COS1
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YOR211C 0.79
MGM1
Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YOR298C-A 0.79
MBF1
Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
YEL072W 0.79
RMD6
Protein required for sporulation
YEL044W 0.79
IES6
Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YMR114C 0.78 Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
YOR020C 0.78
HSP10
Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES
YLR037C 0.77
DAN2
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YIL054W 0.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL015W 0.75
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YJR151C 0.74
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YER189W 0.74 Putative protein of unknown function
YPR010C-A 0.72 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YMR191W 0.72
SPG5
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YDL210W 0.72
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YLR273C 0.72
PIG1
Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
YKL044W 0.72 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL157C 0.71 Putative protein of unknown function
YJR160C 0.71
MPH3
Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YDR250C 0.70 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YGR043C 0.70
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YEL012W 0.69
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YNL143C 0.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL204C 0.69 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR001C 0.69
NTH2
Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses
YJL133C-A 0.69 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL052C 0.68
SPE2
S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
YBR230W-A 0.68 Putative protein of unknown function
YDL033C 0.67
SLM3
tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
YHR033W 0.67 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YDR249C 0.67 Putative protein of unknown function
YDR119W-A 0.67 Putative protein of unknown function
YIL033C 0.67
BCY1
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YHR145C 0.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL008W 0.65 Hypothetical protein predicted to be involved in metabolism
YGL236C 0.65
MTO1
Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
YPL262W 0.64
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YNL283C 0.64
WSC2
Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response

Network of associatons between targets according to the STRING database.

First level regulatory network of MIG2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.2 GO:0006848 pyruvate transport(GO:0006848)
2.3 6.9 GO:0015755 fructose transport(GO:0015755)
1.1 5.5 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
1.1 9.7 GO:0006097 glyoxylate cycle(GO:0006097)
1.0 3.1 GO:0051469 vesicle fusion with vacuole(GO:0051469)
1.0 5.2 GO:0005980 glycogen catabolic process(GO:0005980)
1.0 3.0 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
1.0 4.8 GO:0000023 maltose metabolic process(GO:0000023)
0.9 7.3 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.9 2.7 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.9 3.5 GO:0015793 glycerol transport(GO:0015793)
0.9 4.3 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.7 2.1 GO:0019388 galactose catabolic process(GO:0019388)
0.6 1.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.6 13.5 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.6 3.9 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.6 1.9 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.6 1.8 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.6 6.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.5 1.5 GO:0006740 NADPH regeneration(GO:0006740)
0.5 0.5 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.5 1.4 GO:0019629 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.5 7.0 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.4 1.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.4 0.9 GO:0042843 D-xylose catabolic process(GO:0042843)
0.4 1.3 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.4 4.8 GO:0015696 ammonium transport(GO:0015696)
0.4 4.0 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.4 1.5 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.4 1.9 GO:0006083 acetate metabolic process(GO:0006083)
0.4 3.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.3 0.3 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.3 2.7 GO:0015891 siderophore transport(GO:0015891)
0.3 1.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.3 1.0 GO:0005993 trehalose catabolic process(GO:0005993)
0.3 1.6 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.3 1.3 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.3 0.9 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 4.3 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.3 1.4 GO:0070941 eisosome assembly(GO:0070941)
0.3 1.1 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.3 1.3 GO:0044070 regulation of anion transport(GO:0044070)
0.3 1.3 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.3 2.0 GO:0045332 phospholipid translocation(GO:0045332)
0.3 1.0 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.2 3.6 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.2 0.9 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.2 0.7 GO:0008216 spermidine metabolic process(GO:0008216)
0.2 0.2 GO:0035786 protein complex oligomerization(GO:0035786)
0.2 0.6 GO:0006545 glycine biosynthetic process(GO:0006545)
0.2 0.6 GO:0006311 meiotic gene conversion(GO:0006311)
0.2 5.4 GO:0006094 gluconeogenesis(GO:0006094)
0.2 1.1 GO:0015908 fatty acid transport(GO:0015908)
0.2 1.1 GO:0042407 cristae formation(GO:0042407)
0.2 0.3 GO:0006102 isocitrate metabolic process(GO:0006102)
0.2 2.8 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.2 0.5 GO:0000409 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.1 0.4 GO:0044209 AMP salvage(GO:0044209)
0.1 0.6 GO:0032373 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.1 6.3 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.6 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.1 0.5 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.4 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 0.4 GO:0015976 carbon utilization(GO:0015976)
0.1 0.4 GO:0015691 cadmium ion transport(GO:0015691)
0.1 1.0 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.4 GO:0006003 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.2 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.4 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.1 1.0 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 1.6 GO:0007129 synapsis(GO:0007129)
0.1 1.2 GO:0006754 ATP biosynthetic process(GO:0006754)
0.1 0.4 GO:0015804 neutral amino acid transport(GO:0015804)
0.1 0.1 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.1 0.2 GO:0046033 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.1 0.3 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.1 0.5 GO:0006829 zinc II ion transport(GO:0006829)
0.1 1.5 GO:0042026 protein refolding(GO:0042026)
0.1 0.3 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 0.3 GO:0032365 intracellular lipid transport(GO:0032365)
0.1 0.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.1 1.0 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 0.5 GO:0006855 drug transmembrane transport(GO:0006855)
0.1 0.2 GO:0015886 heme transport(GO:0015886)
0.1 0.2 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.5 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.1 0.6 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.3 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 0.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.5 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.1 0.5 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 1.3 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.2 GO:0019346 transsulfuration(GO:0019346)
0.1 0.3 GO:0043461 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.1 0.7 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.1 0.1 GO:0042148 strand invasion(GO:0042148)
0.1 0.7 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.6 GO:0006826 iron ion transport(GO:0006826)
0.1 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.0 0.1 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.0 0.2 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.0 0.4 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.5 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.2 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.8 GO:0001101 response to acid chemical(GO:0001101)
0.0 0.2 GO:0043954 cellular component maintenance(GO:0043954)
0.0 0.2 GO:0001666 response to hypoxia(GO:0001666)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.8 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0009098 leucine biosynthetic process(GO:0009098)
0.0 0.8 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.1 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322)
0.0 0.6 GO:0022900 electron transport chain(GO:0022900)
0.0 0.3 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.6 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.2 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.0 0.1 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.3 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.7 GO:1902653 secondary alcohol biosynthetic process(GO:1902653)
0.0 1.0 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.2 GO:0009092 homoserine metabolic process(GO:0009092)
0.0 0.1 GO:0045861 negative regulation of proteolysis(GO:0045861)
0.0 1.1 GO:0006631 fatty acid metabolic process(GO:0006631)
0.0 0.1 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.4 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0019627 urea metabolic process(GO:0019627)
0.0 0.2 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0018410 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.0 0.1 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.3 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.8 GO:0042176 regulation of protein catabolic process(GO:0042176)
0.0 0.1 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.0 0.1 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.0 0.9 GO:0006839 mitochondrial transport(GO:0006839)
0.0 0.1 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.1 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.0 0.3 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.0 GO:0055088 lipid homeostasis(GO:0055088)
0.0 0.2 GO:0034620 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.0 0.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.0 GO:0042710 biofilm formation(GO:0042710)
0.0 0.0 GO:0008272 sulfate transport(GO:0008272)
0.0 0.1 GO:0060211 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196) regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.0 0.1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.3 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.6 5.7 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.6 1.7 GO:0046930 pore complex(GO:0046930)
0.5 1.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 3.1 GO:0034657 GID complex(GO:0034657)
0.4 3.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 0.8 GO:0030061 mitochondrial crista(GO:0030061)
0.3 2.8 GO:0042597 periplasmic space(GO:0042597)
0.3 1.0 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.3 1.0 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.3 0.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 2.8 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.2 3.1 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.2 1.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 12.8 GO:0005576 extracellular region(GO:0005576)
0.2 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 0.6 GO:0000817 COMA complex(GO:0000817)
0.1 3.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.5 GO:0070469 respiratory chain(GO:0070469)
0.1 1.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 19.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.4 GO:0001400 mating projection base(GO:0001400)
0.1 2.9 GO:0009277 fungal-type cell wall(GO:0009277)
0.1 3.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.4 GO:0005884 actin filament(GO:0005884)
0.1 0.4 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.9 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 37.5 GO:0005739 mitochondrion(GO:0005739)
0.1 1.1 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 0.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0032126 eisosome(GO:0032126)
0.0 0.1 GO:0008623 CHRAC(GO:0008623)
0.0 0.1 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0034967 Set3 complex(GO:0034967)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.0 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 3.8 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.1 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 0.1 GO:0032221 Rpd3S complex(GO:0032221)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.3 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
2.3 11.6 GO:0015295 solute:proton symporter activity(GO:0015295)
2.2 6.7 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.9 7.4 GO:0004396 hexokinase activity(GO:0004396)
1.6 6.6 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
1.4 4.2 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.3 4.0 GO:0048038 quinone binding(GO:0048038)
1.0 3.9 GO:0005537 mannose binding(GO:0005537)
0.9 2.7 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.7 2.2 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.7 5.4 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.7 2.0 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.6 4.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.6 1.7 GO:0022829 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.6 1.1 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.6 1.7 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.5 2.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.5 2.3 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.4 4.5 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.4 1.1 GO:0016208 AMP binding(GO:0016208)
0.4 2.6 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.4 1.1 GO:0015294 solute:cation symporter activity(GO:0015294)
0.3 3.4 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.3 1.0 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.3 1.0 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.3 5.3 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.3 1.9 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.3 3.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.3 0.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 3.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.3 0.8 GO:0005536 glucose binding(GO:0005536)
0.3 2.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 1.9 GO:0030246 carbohydrate binding(GO:0030246)
0.3 1.6 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 1.0 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.3 3.8 GO:0015297 antiporter activity(GO:0015297)
0.3 1.0 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.2 0.7 GO:0016289 CoA hydrolase activity(GO:0016289)
0.2 0.9 GO:0032452 demethylase activity(GO:0032451) histone demethylase activity(GO:0032452)
0.2 0.9 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.2 0.9 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 0.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 2.7 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.2 0.5 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.2 0.3 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.2 0.7 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 0.8 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.2 0.5 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 1.8 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 1.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.7 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.1 1.3 GO:0010181 FMN binding(GO:0010181)
0.1 0.6 GO:0008198 ferrous iron binding(GO:0008198)
0.1 0.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 0.4 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 1.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.5 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.1 1.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.6 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 0.3 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.1 0.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.3 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 0.6 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.4 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 1.6 GO:0050661 NADP binding(GO:0050661)
0.1 0.7 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 0.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 2.5 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 0.7 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 1.5 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.2 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.1 0.6 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.1 0.5 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 1.3 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.1 1.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.2 GO:0019003 GDP binding(GO:0019003)
0.1 0.2 GO:0004629 phospholipase C activity(GO:0004629)
0.1 0.6 GO:0004872 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.1 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.2 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.1 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0 0.1 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.8 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 6.6 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 1.4 GO:0050662 coenzyme binding(GO:0050662)
0.0 0.6 GO:0016298 lipase activity(GO:0016298)
0.0 0.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.2 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.5 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
0.0 0.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.3 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.2 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.3 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0070336 flap-structured DNA binding(GO:0070336)
0.0 0.1 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.0 GO:0032183 SUMO binding(GO:0032183)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0043138 3'-5' DNA helicase activity(GO:0043138) ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.0 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.0 0.2 GO:0003713 transcription coactivator activity(GO:0003713)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 2.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.3 0.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 0.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 0.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 15.7 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.9 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.3 2.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 0.1 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.1 0.3 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.1 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.0 0.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 15.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis