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Results for MIG3

Z-value: 1.44

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Transcription factors associated with MIG3

Gene Symbol Gene ID Gene Info
MIG3
S000000830 Transcriptional regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MIG3YER028C-0.203.3e-01Click!

Activity profile of MIG3 motif

Sorted Z-values of MIG3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YDR342C 25.67
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YGR067C 21.67 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YGR243W 17.30
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR073C 13.68 Putative mannitol dehydrogenase
YDR536W 12.28
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YFR053C 12.16
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YDR343C 11.85
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YOR100C 11.62
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YMR107W 11.53
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YLR327C 11.40
TMA10
Protein of unknown function that associates with ribosomes
YKL217W 11.36
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YPR030W 10.67
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YIL162W 10.19
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YEL070W 9.59
DSF1
Deletion suppressor of mpt5 mutation
YLR023C 9.42
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YPR184W 8.89
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YDR277C 8.85
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YFR017C 8.57 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YFL052W 8.46 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YER065C 8.43
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YER084W 8.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL117W 8.08
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YOL052C-A 7.55
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YML089C 7.25 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YPL119C 7.21
DBP1
Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs
YOR382W 7.20
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YMR081C 7.19
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YJR115W 7.19 Putative protein of unknown function
YLR312C 6.95
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YBR033W 6.92
EDS1
Putative zinc cluster protein; YBR033W is not an essential gene
YIL057C 6.75 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YNR002C 6.69
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YOR383C 6.61
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YHR211W 6.52
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YML042W 6.49
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YOR343C 6.41 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YKL109W 6.36
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YDL244W 6.29
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YBR105C 6.05
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YMR194C-B 5.96 Putative protein of unknown function
YDR178W 5.94
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YGL180W 5.74
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YLR377C 5.71
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YGR183C 5.69
QCR9
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YKL093W 5.65
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YGL033W 5.62
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YOR178C 5.58
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YBR297W 5.50
MAL33
MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YEL011W 5.49
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YCR010C 5.49
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YHR092C 5.46
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YHL032C 5.33
GUT1
Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
YLR004C 5.22
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YMR104C 5.17
YPK2
Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YIL155C 5.12
GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YJR159W 5.07
SOR1
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YOL051W 4.97
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YCR091W 4.82
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YCR007C 4.79 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YBR230C 4.72
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YJL166W 4.69
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YLR149C 4.69 Putative protein of unknown function; YLR149C is not an essential gene
YBR051W 4.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YGL146C 4.55 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YMR114C 4.47 Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
YBR050C 4.47
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YPL201C 4.40
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YDL214C 4.37
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YMR105C 4.34
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YML090W 4.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YOL154W 4.31
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YHR217C 4.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YPL230W 4.19
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YAL039C 4.19
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YBR019C 4.14
GAL10
UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
YDL246C 4.04
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YER004W 3.94
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YPR010C-A 3.87 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YIL055C 3.86 Putative protein of unknown function
YMR272C 3.84
SCS7
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YDL079C 3.78
MRK1
Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YKR102W 3.77
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YML120C 3.76
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YFL011W 3.75
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YDL130W-A 3.74
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YPL134C 3.71
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YLR174W 3.70
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YKR097W 3.63
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YHR033W 3.55 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YIL024C 3.52 Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
YKR067W 3.46
GPT2
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YBL015W 3.40
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YHR210C 3.36 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YML091C 3.35
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YPL036W 3.35
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YFL055W 3.34
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YAR035W 3.33
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YER150W 3.31
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YLR273C 3.26
PIG1
Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
YFL054C 3.26 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YMR195W 3.23
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YCL001W-B 3.21 Putative protein of unknown function; identified by homology
YPR150W 3.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YOR376W 3.15 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YJR160C 3.14
MPH3
Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YBR132C 3.14
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YNL074C 3.12
MLF3
Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YKL031W 3.08 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YPL186C 3.07
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YJR154W 3.06 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YFL036W 3.05
RPO41
Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YNL125C 3.04
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YMR280C 2.98
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YDL245C 2.96
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YEL074W 2.96 Hypothetical protein
YER121W 2.94 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YEL012W 2.93
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YGR288W 2.90
MAL13
MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
YHR095W 2.90 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL063W 2.85 Dubious open reading frame, based on available experimental and comparative sequence data
YHL021C 2.81
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YIL125W 2.79
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YKL141W 2.77
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YHR218W 2.69 Helicase-like protein encoded within the telomeric Y' element
YOR020W-A 2.69 Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL185W 2.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YEL044W 2.64
IES6
Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YJR120W 2.60 Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YPL200W 2.59
CSM4
Protein required for accurate chromosome segregation during meiosis
YPL040C 2.59
ISM1
Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
YPL156C 2.57
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YKL188C 2.56
PXA2
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YOR328W 2.55
PDR10
ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
YBR056W-A 2.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YKR066C 2.53
CCP1
Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YDR009W 2.52
GAL3
Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
YAL054C 2.51
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YMR206W 2.50 Putative protein of unknown function; YMR206W is not an essential gene
YEL075C 2.45 Putative protein of unknown function
YFL064C 2.43 Putative protein of unknown function
YBR020W 2.41
GAL1
Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p
YJL116C 2.41
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YDR010C 2.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCL054W 2.36
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YHR145C 2.35 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER066W 2.34 Putative protein of unknown function; YER066W is not an essential gene
YLR267W 2.33
BOP2
Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YDL194W 2.30
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YDR247W 2.30
VHS1
Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YER188C-A 2.27 Putative protein of unknown function
YLR111W 2.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR073W-A 2.27
SOL2
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p
YMR180C 2.26
CTL1
RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm
YBR230W-A 2.24 Putative protein of unknown function
YGR161C 2.23
RTS3
Putative component of the protein phosphatase type 2A complex
YGR043C 2.21
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YER067W 2.19 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YOR338W 2.18 Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen
YLL039C 2.18
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YDR096W 2.18
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YDR085C 2.16
AFR1
Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p
YPR001W 2.15
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YDL210W 2.14
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YFL053W 2.14
DAK2
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YBR021W 2.13
FUR4
Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
YEL049W 2.11
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YBR203W 2.10
COS111
Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR071C 2.10 Putative protein of unknown function
YOR186C-A 2.08 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGR144W 2.08
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YMR191W 2.07
SPG5
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YDR119W-A 2.07 Putative protein of unknown function
YEL008W 2.07 Hypothetical protein predicted to be involved in metabolism
YLR258W 2.04
GSY2
Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YER142C 2.03
MAG1
3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired
YDL021W 2.02
GPM2
Homolog of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YER187W 2.00 Putative protein of unknown function; induced in respiratory-deficient cells
YER098W 1.96
UBP9
Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YNL144C 1.94 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YER189W 1.93 Putative protein of unknown function
YBL033C 1.91
RIB1
GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YEL009C 1.89
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YJR151C 1.88
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YDR441C 1.85
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YLR037C 1.84
DAN2
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YOL159C 1.84 Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
YFL062W 1.81
COS4
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YKR049C 1.79
FMP46
Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR113W 1.78
AZF1
Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance
YPR013C 1.76 Putative zinc finger protein; YPR013C is not an essential gene
YJL133C-A 1.76 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL084W 1.75
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YDR250C 1.75 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YDR234W 1.73
LYS4
Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YNL036W 1.72
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YJL199C 1.71
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YAL060W 1.70
BDH1
NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
YOR020C 1.68
HSP10
Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES
YNL283C 1.67
WSC2
Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YCR005C 1.62
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors

Network of associatons between targets according to the STRING database.

First level regulatory network of MIG3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 28.3 GO:0006848 pyruvate transport(GO:0006848)
3.8 11.4 GO:0015755 fructose transport(GO:0015755)
3.3 9.8 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
2.8 25.3 GO:0006097 glyoxylate cycle(GO:0006097)
2.6 10.4 GO:0015793 glycerol transport(GO:0015793)
2.5 12.7 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
2.3 7.0 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
2.1 10.7 GO:0005980 glycogen catabolic process(GO:0005980)
2.0 6.0 GO:0051469 vesicle fusion with vacuole(GO:0051469)
1.9 9.7 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.8 10.7 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.8 12.4 GO:0000023 maltose metabolic process(GO:0000023)
1.7 10.2 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
1.6 4.8 GO:0019541 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.4 4.3 GO:0019388 galactose catabolic process(GO:0019388)
1.4 11.5 GO:0015891 siderophore transport(GO:0015891)
1.4 4.2 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.3 13.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.3 27.8 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
1.3 3.9 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
1.2 3.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.2 11.2 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.2 17.8 GO:0005978 glycogen biosynthetic process(GO:0005978)
1.1 7.7 GO:0006083 acetate metabolic process(GO:0006083)
1.1 3.2 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
1.0 3.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
1.0 1.0 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
1.0 4.0 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
1.0 1.0 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
0.9 13.1 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.9 9.3 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.9 1.7 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.9 3.5 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.9 5.2 GO:0070941 eisosome assembly(GO:0070941)
0.8 13.5 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.8 3.2 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.7 2.8 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.7 1.4 GO:0042843 D-xylose catabolic process(GO:0042843)
0.7 4.8 GO:0045332 phospholipid translocation(GO:0045332)
0.6 2.6 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.6 10.7 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.6 1.8 GO:0044209 AMP salvage(GO:0044209)
0.6 3.0 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.6 1.7 GO:0015976 carbon utilization(GO:0015976)
0.5 1.6 GO:0046352 trehalose catabolic process(GO:0005993) disaccharide catabolic process(GO:0046352)
0.5 2.1 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.5 1.6 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.5 10.3 GO:0019740 nitrogen utilization(GO:0019740)
0.5 2.0 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.5 3.0 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322)
0.5 13.2 GO:0006094 gluconeogenesis(GO:0006094)
0.5 1.0 GO:0042710 biofilm formation(GO:0042710)
0.5 1.4 GO:0019627 urea metabolic process(GO:0019627) nitrogen cycle metabolic process(GO:0071941)
0.5 1.4 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.5 0.9 GO:0006102 isocitrate metabolic process(GO:0006102)
0.5 2.8 GO:0006855 drug transmembrane transport(GO:0006855)
0.4 1.2 GO:0008216 spermidine metabolic process(GO:0008216)
0.4 5.2 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.4 5.8 GO:0007129 synapsis(GO:0007129)
0.4 0.8 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.4 5.6 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.4 1.1 GO:0006598 polyamine catabolic process(GO:0006598)
0.4 1.1 GO:0000411 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.4 0.7 GO:0006167 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.4 1.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.3 1.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.3 1.7 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.3 4.9 GO:0006754 ATP biosynthetic process(GO:0006754)
0.3 13.5 GO:0009060 aerobic respiration(GO:0009060)
0.3 1.5 GO:0051274 beta-glucan biosynthetic process(GO:0051274)
0.3 2.4 GO:0031167 rRNA methylation(GO:0031167)
0.3 0.3 GO:0043902 positive regulation of multi-organism process(GO:0043902)
0.3 1.1 GO:0034764 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.3 1.6 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.3 0.8 GO:0006545 glycine biosynthetic process(GO:0006545)
0.3 1.3 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.3 0.8 GO:0071456 cellular response to hypoxia(GO:0071456)
0.3 1.3 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.2 2.5 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 1.6 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.2 7.0 GO:0022900 electron transport chain(GO:0022900)
0.2 0.4 GO:0042148 strand invasion(GO:0042148)
0.2 2.6 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.2 3.2 GO:0042026 protein refolding(GO:0042026)
0.2 3.9 GO:0016579 protein deubiquitination(GO:0016579)
0.2 1.3 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.2 0.7 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.2 0.2 GO:0001666 response to hypoxia(GO:0001666)
0.2 0.7 GO:0072485 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.2 1.2 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.2 0.7 GO:0045033 peroxisome inheritance(GO:0045033)
0.2 1.2 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.2 1.3 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.2 1.6 GO:0009092 homoserine metabolic process(GO:0009092)
0.2 0.5 GO:0030048 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 1.8 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.4 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324) age-dependent general metabolic decline(GO:0007571)
0.1 1.0 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.3 GO:0008272 sulfate transport(GO:0008272)
0.1 1.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 0.6 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.1 5.5 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 0.5 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.1 0.4 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.6 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.1 2.1 GO:0043248 proteasome assembly(GO:0043248)
0.1 2.1 GO:0001101 response to acid chemical(GO:0001101)
0.1 0.3 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.1 0.5 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.7 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 1.8 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.3 GO:0060194 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.1 0.3 GO:0015691 cadmium ion transport(GO:0015691)
0.1 0.7 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 0.7 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.1 0.3 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.1 0.2 GO:0006311 meiotic gene conversion(GO:0006311)
0.1 1.1 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.1 GO:0044154 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.1 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 0.4 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.1 0.8 GO:0046173 polyol biosynthetic process(GO:0046173)
0.1 1.5 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.1 0.3 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.8 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.5 GO:0006826 iron ion transport(GO:0006826)
0.1 0.4 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 2.0 GO:0042176 regulation of protein catabolic process(GO:0042176)
0.0 0.5 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:0042732 D-xylose metabolic process(GO:0042732)
0.0 0.6 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.5 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.0 0.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0051292 cellular component maintenance(GO:0043954) pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.3 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.2 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.0 0.2 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.2 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.7 GO:0042493 response to drug(GO:0042493)
0.0 0.5 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 1.6 GO:0006839 mitochondrial transport(GO:0006839)
0.0 0.7 GO:0019318 hexose metabolic process(GO:0019318)
0.0 0.1 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.0 0.2 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.2 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.0 0.3 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.1 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.0 0.2 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.2 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.2 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.0 0.3 GO:0008361 regulation of cell size(GO:0008361)
0.0 0.1 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.2 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.1 GO:0045861 negative regulation of proteolysis(GO:0045861)
0.0 0.2 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.0 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.0 0.0 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of sulfur metabolic process(GO:0042762)
0.0 0.1 GO:0048017 inositol lipid-mediated signaling(GO:0048017)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 9.7 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.7 5.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
1.7 13.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.6 6.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.3 11.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.9 2.8 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.9 6.0 GO:0034657 GID complex(GO:0034657)
0.8 2.3 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.8 1.5 GO:0030061 mitochondrial crista(GO:0030061)
0.8 9.0 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.7 2.2 GO:0001400 mating projection base(GO:0001400)
0.7 5.7 GO:0042597 periplasmic space(GO:0042597)
0.7 2.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.5 9.2 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.4 21.9 GO:0031225 anchored component of membrane(GO:0031225)
0.4 0.7 GO:0046930 pore complex(GO:0046930)
0.4 5.3 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.3 1.4 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.3 1.0 GO:0005796 Golgi lumen(GO:0005796)
0.3 50.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 4.2 GO:0070469 respiratory chain(GO:0070469)
0.3 2.6 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 0.9 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.3 5.3 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 1.9 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.3 2.6 GO:0030677 ribonuclease P complex(GO:0030677)
0.3 2.3 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.3 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 4.6 GO:0070847 core mediator complex(GO:0070847)
0.2 1.4 GO:0034967 Set3 complex(GO:0034967)
0.2 5.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 2.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 0.7 GO:0008623 CHRAC(GO:0008623)
0.2 3.5 GO:0009277 fungal-type cell wall(GO:0009277)
0.2 3.3 GO:0005811 lipid particle(GO:0005811)
0.2 0.3 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.6 GO:0032126 eisosome(GO:0032126)
0.1 1.9 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 3.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 4.5 GO:0005576 extracellular region(GO:0005576)
0.1 1.2 GO:0000974 Prp19 complex(GO:0000974)
0.1 7.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 0.6 GO:0016592 mediator complex(GO:0016592)
0.1 1.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.0 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.3 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 0.2 GO:0070985 TFIIK complex(GO:0070985)
0.1 57.4 GO:0005739 mitochondrion(GO:0005739)
0.1 1.1 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.3 GO:0030478 actin cap(GO:0030478)
0.1 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.3 GO:0032221 Rpd3S complex(GO:0032221)
0.1 1.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.2 GO:0000942 condensed chromosome outer kinetochore(GO:0000940) condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0031011 Ino80 complex(GO:0031011)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 16.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
5.1 25.6 GO:0015295 solute:proton symporter activity(GO:0015295)
3.4 10.2 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
3.3 9.8 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
3.0 8.9 GO:0090599 alpha-glucosidase activity(GO:0090599)
2.9 8.7 GO:0048038 quinone binding(GO:0048038)
2.7 10.7 GO:0005537 mannose binding(GO:0005537)
2.6 10.2 GO:0004396 hexokinase activity(GO:0004396)
2.3 9.3 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
2.0 4.0 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.5 4.5 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.4 4.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.4 9.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.3 10.4 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.3 3.8 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.2 5.0 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
1.1 13.8 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.1 3.4 GO:0016289 CoA hydrolase activity(GO:0016289)
1.1 12.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
1.1 4.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
1.1 8.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.0 5.1 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.0 9.8 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.9 11.4 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.9 7.9 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.8 2.5 GO:0016878 AMP binding(GO:0016208) CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.8 2.4 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.8 2.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.8 2.3 GO:0005536 glucose binding(GO:0005536)
0.7 2.2 GO:0015294 solute:cation symporter activity(GO:0015294)
0.7 0.7 GO:0032452 histone demethylase activity(GO:0032452)
0.7 2.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.7 2.8 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.7 2.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.7 2.0 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.6 10.7 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.6 4.1 GO:0030246 carbohydrate binding(GO:0030246)
0.6 2.4 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.6 2.3 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.5 1.6 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.5 2.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.5 2.9 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.5 1.9 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.5 0.9 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.5 2.3 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.5 1.4 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.4 2.1 GO:0008198 ferrous iron binding(GO:0008198)
0.4 2.0 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.4 1.2 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.4 3.5 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.4 2.7 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.4 1.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.4 4.5 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.4 1.1 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.3 6.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 2.2 GO:0019238 cyclohydrolase activity(GO:0019238)
0.3 2.9 GO:0005057 receptor signaling protein activity(GO:0005057)
0.3 0.9 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.3 1.6 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.3 4.8 GO:0015297 antiporter activity(GO:0015297)
0.3 2.4 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.3 1.8 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.3 0.9 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.3 1.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 2.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.3 2.0 GO:0050661 NADP binding(GO:0050661)
0.2 0.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 0.7 GO:0015288 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.2 1.8 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.2 0.6 GO:0032183 SUMO binding(GO:0032183)
0.2 2.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.2 1.8 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 1.8 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 20.1 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.2 1.0 GO:0016783 sulfurtransferase activity(GO:0016783)
0.2 11.5 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors(GO:0016614)
0.2 1.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 1.6 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 0.7 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 1.7 GO:0004872 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.2 0.5 GO:0004629 phospholipase C activity(GO:0004629)
0.2 1.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 0.5 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.3 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.1 0.4 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 1.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 4.2 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 2.5 GO:0004843 obsolete ubiquitin thiolesterase activity(GO:0004221) thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 1.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.4 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 2.6 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.1 0.6 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.5 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.5 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.2 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 1.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 3.9 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.1 0.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 1.2 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 3.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.4 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 0.6 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.5 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.1 1.7 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 1.3 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
0.1 0.4 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 1.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.7 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.1 0.2 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.1 1.1 GO:0016298 lipase activity(GO:0016298)
0.1 0.6 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.6 GO:0045182 translation regulator activity(GO:0045182)
0.1 1.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.6 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.1 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.3 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0045118 azole transporter activity(GO:0045118)
0.0 0.5 GO:0043138 3'-5' DNA helicase activity(GO:0043138) ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.4 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.8 GO:0051087 chaperone binding(GO:0051087)
0.0 0.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.8 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 2.3 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 1.2 GO:0032182 ubiquitin-like protein binding(GO:0032182) ubiquitin binding(GO:0043130)
0.0 0.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.3 GO:0015238 drug transmembrane transporter activity(GO:0015238) drug transporter activity(GO:0090484)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691) G-quadruplex DNA binding(GO:0051880)
0.0 0.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.3 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 1.2 GO:0032403 protein complex binding(GO:0032403)
0.0 0.0 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.1 3.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.8 4.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.5 3.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.5 1.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 0.2 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.1 0.2 PID AURORA B PATHWAY Aurora B signaling
0.0 61.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.1 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 14.6 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.7 3.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.7 3.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.5 1.6 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.3 1.0 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.4 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.1 0.1 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.0 60.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.1 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling