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Results for MSN4

Z-value: 1.01

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Transcription factors associated with MSN4

Gene Symbol Gene ID Gene Info
MSN4
S000001545 Transcriptional activator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSN4YKL062W0.723.4e-05Click!

Activity profile of MSN4 motif

Sorted Z-values of MSN4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YMR175W 21.30
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YNR034W-A 20.11 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YOL052C-A 18.17
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YFR053C 15.03
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YKL217W 14.69
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YLR312C 13.40
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YBR072W 12.52
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YER150W 11.96
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YMR105C 11.83
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YMR206W 11.81 Putative protein of unknown function; YMR206W is not an essential gene
YOR393W 11.79
ERR1
Protein of unknown function, has similarity to enolases
YEL039C 11.47
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YNL117W 10.61
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YHR096C 9.88
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YDR343C 9.80
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YOL084W 9.38
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YGR087C 9.32
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YAR053W 8.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL136W 8.47
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YMR174C 8.47
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YOR100C 8.43
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YFR017C 8.32 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YBR201C-A 8.32 Putative protein of unknown function
YBL015W 8.05
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YKL163W 7.71
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YDR171W 7.66
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YPL054W 7.56
LEE1
Zinc-finger protein of unknown function
YER103W 7.47
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YAL061W 7.47
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YHR139C 7.31
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YAR060C 7.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR149C 6.94 Putative protein of unknown function; YLR149C is not an essential gene
YOR391C 6.93
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YER067W 6.79 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YMR081C 6.75
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YEL011W 6.74
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YER065C 6.64
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YNL194C 6.60 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YHL021C 6.52
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YDL210W 6.51
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YGR088W 6.39
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YMR107W 6.30
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YAR050W 6.23
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YBL049W 6.12
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YDR258C 6.10
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YKL026C 6.06
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YLR377C 6.05
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YHR092C 6.01
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YDR277C 5.95
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YMR169C 5.95
ALD3
Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YIL099W 5.84
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YAL039C 5.67
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YPL036W 5.64
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YMR251W 5.61
GTO3
Omega class glutathione transferase; putative cytosolic localization
YGR201C 5.60 Putative protein of unknown function
YHR212C 5.59 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL089W 5.57
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YPL247C 5.49 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; YPL247C is not an essential gene
YKL148C 5.48
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YJR115W 5.48 Putative protein of unknown function
YPR026W 5.44
ATH1
Acid trehalase required for utilization of extracellular trehalose
YCR021C 5.43
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YOR348C 5.34
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YGR243W 5.34
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR342C 5.19
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YNL093W 5.19
YPT53
GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YBR147W 5.16
RTC2
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YAL034C 5.11
FUN19
Non-essential protein of unknown function
YAR047C 5.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL230W 5.02
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YHR212W-A 4.99 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPR010C-A 4.97 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YPL271W 4.90
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YPR160W 4.78
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YGR070W 4.74
ROM1
GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YIL045W 4.67
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YHR087W 4.57
RTC3
Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity
YGR067C 4.54 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YDR096W 4.53
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YOL082W 4.52
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YPR184W 4.51
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YEL008W 4.44 Hypothetical protein predicted to be involved in metabolism
YDL204W 4.44
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YLL026W 4.38
HSP104
Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YPR036W-A 4.36 Protein of unknown function; transcription is regulated by Pdr1p
YKL093W 4.28
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YJL067W 4.26 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR015C 4.23
GSY1
Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YKL109W 4.21
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YNL305C 4.20 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YJL103C 4.20
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YPL186C 4.18
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YML128C 4.17
MSC1
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YHR138C 4.17 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YBR214W 4.06
SDS24
One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YKL031W 4.01 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YHL040C 4.00
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YIL101C 4.00
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YDL214C 3.99
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YOR186W 3.94 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YFL030W 3.92
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YDR070C 3.92
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR173W 3.89
DCS2
Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YEL009C 3.87
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YOR392W 3.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat
YPR027C 3.81 Putative protein of unknown function
YAL062W 3.79
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YAL054C 3.79
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YHR001W-A 3.77
QCR10
Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YIL122W 3.76
POG1
Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YPL185W 3.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YML100W 3.75
TSL1
Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YOR285W 3.72 Protein of unknown function, localized to the mitochondrial outer membrane
YPL240C 3.69
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YLL041C 3.69
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YGR236C 3.66
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR178C 3.65
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YOL085W-A 3.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YBR117C 3.56
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YOR120W 3.56
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YPL223C 3.53
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YJL066C 3.50
MPM1
Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches
YBR269C 3.49
FMP21
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL078C 3.48
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YDL130W-A 3.47
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YJR146W 3.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YML089C 3.43 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YIL162W 3.43
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YNR001C 3.40
CIT1
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YDR119W-A 3.40 Putative protein of unknown function
YJR096W 3.35 Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YGR258C 3.32
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YDR234W 3.29
LYS4
Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YIL066C 3.28
RNR3
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YGR248W 3.25
SOL4
6-phosphogluconolactonase with similarity to Sol3p
YDL169C 3.23
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YDL181W 3.23
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YLR258W 3.22
GSY2
Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YMR250W 3.20
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YPL017C 3.20
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YIL057C 3.19 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YJL144W 3.18 Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YKL085W 3.18
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YIR039C 3.14
YPS6
Putative GPI-anchored aspartic protease
YMR118C 3.12 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YML120C 3.11
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YOR066W 3.09
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YPL250C 3.09
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YMR194C-B 3.08 Putative protein of unknown function
YAL005C 3.07
SSA1
ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YLR080W 3.06
EMP46
Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YMR181C 3.06 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YJL141C 3.04
YAK1
Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal
YFL058W 3.03
THI5
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YOL118C 3.03 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGL045W 3.02
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YJL045W 2.99 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YOL060C 2.98
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YJL116C 2.96
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YNL077W 2.95
APJ1
Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR017W 2.93
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YLL053C 2.88 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YLR294C 2.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
YMR244W 2.85 Putative protein of unknown function
YLR122C 2.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YOR346W 2.83
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YLL019C 2.81
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YDR018C 2.81 Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype
YIL100C-A 2.80 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL154W 2.80
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YBR050C 2.77
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YDR178W 2.76
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YLR178C 2.75
TFS1
Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway
YOR374W 2.74
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YBR051W 2.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YBR183W 2.74
YPC1
Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YOR211C 2.73
MGM1
Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YFR022W 2.73
ROG3
Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YGR069W 2.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR230C 2.70
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YFL052W 2.68 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YOL047C 2.67 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YEL070W 2.65
DSF1
Deletion suppressor of mpt5 mutation
YGR256W 2.65
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YOR065W 2.64
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YOR382W 2.62
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YKL107W 2.61 Putative protein of unknown function
YPL156C 2.61
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YPL229W 2.60 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene
YKL177W 2.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YFL054C 2.60 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YMR280C 2.59
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YER088C 2.58
DOT6
Protein of unknown function, involved in telomeric gene silencing and filamentation
YMR297W 2.58
PRC1
Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YBR132C 2.58
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YLL052C 2.53
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YCR005C 2.52
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YJL102W 2.52
MEF2
Mitochondrial elongation factor involved in translational elongation
YMR196W 2.51 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
YNL055C 2.50
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated

Network of associatons between targets according to the STRING database.

First level regulatory network of MSN4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 21.6 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
5.1 20.4 GO:0006848 pyruvate transport(GO:0006848)
4.8 14.5 GO:0015755 fructose transport(GO:0015755)
4.2 12.5 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
4.0 12.1 GO:0032780 negative regulation of ATPase activity(GO:0032780)
3.9 11.8 GO:0043335 protein unfolding(GO:0043335)
3.0 15.0 GO:0005980 glycogen catabolic process(GO:0005980)
2.9 8.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
2.9 11.4 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
2.7 8.2 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
2.6 7.9 GO:0005993 trehalose catabolic process(GO:0005993)
2.6 20.8 GO:0006097 glyoxylate cycle(GO:0006097)
2.5 12.3 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
2.2 21.7 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
2.1 8.6 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.9 5.7 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.9 5.7 GO:0042843 D-xylose catabolic process(GO:0042843)
1.8 12.5 GO:0006083 acetate metabolic process(GO:0006083)
1.8 7.1 GO:0006598 polyamine catabolic process(GO:0006598)
1.7 25.5 GO:0005978 glycogen biosynthetic process(GO:0005978)
1.7 9.9 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.6 6.5 GO:0015804 neutral amino acid transport(GO:0015804)
1.6 4.7 GO:0090630 activation of GTPase activity(GO:0090630)
1.5 4.5 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
1.5 7.5 GO:0032974 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
1.4 5.5 GO:0015847 putrescine transport(GO:0015847)
1.3 5.2 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
1.3 3.9 GO:0006545 glycine biosynthetic process(GO:0006545)
1.3 3.9 GO:0006108 malate metabolic process(GO:0006108)
1.2 11.0 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
1.2 6.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
1.2 4.8 GO:0071467 cellular response to pH(GO:0071467)
1.2 3.6 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
1.2 3.5 GO:0000200 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
1.1 3.4 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
1.1 2.3 GO:0042732 D-xylose metabolic process(GO:0042732)
1.1 3.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
1.1 23.5 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
1.1 4.4 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
1.1 17.3 GO:0006754 ATP biosynthetic process(GO:0006754)
1.1 3.2 GO:0006538 glutamate catabolic process(GO:0006538)
1.0 3.1 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
1.0 4.0 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
1.0 3.9 GO:0019748 secondary metabolic process(GO:0019748)
0.9 6.4 GO:0015891 siderophore transport(GO:0015891)
0.9 0.9 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.9 1.7 GO:0072353 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
0.9 4.3 GO:0043954 cellular component maintenance(GO:0043954)
0.8 4.1 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.8 7.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.8 4.0 GO:0046058 cAMP metabolic process(GO:0046058)
0.8 2.3 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.7 14.1 GO:0001101 response to acid chemical(GO:0001101)
0.7 2.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.7 3.6 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.7 7.6 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.7 5.3 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.6 1.3 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.6 6.1 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.6 1.8 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.6 10.0 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.6 1.7 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.6 1.7 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.6 2.2 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.6 3.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.6 12.7 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.5 2.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.5 0.5 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.5 1.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.5 1.0 GO:0071456 response to hypoxia(GO:0001666) cellular response to hypoxia(GO:0071456)
0.5 1.5 GO:0033499 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.5 1.4 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.5 2.9 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.5 3.3 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.5 1.9 GO:0046185 aldehyde catabolic process(GO:0046185)
0.5 0.9 GO:2000197 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.5 6.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.5 0.5 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.4 7.1 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.4 2.7 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.4 2.2 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.4 2.1 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.4 2.1 GO:0000023 maltose metabolic process(GO:0000023)
0.4 3.5 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.4 3.5 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.4 1.9 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.4 1.9 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.4 1.5 GO:0016242 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.4 2.6 GO:0006639 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.4 1.1 GO:0034389 lipid particle organization(GO:0034389)
0.4 1.1 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.4 1.1 GO:0015976 carbon utilization(GO:0015976)
0.4 6.1 GO:0006094 gluconeogenesis(GO:0006094)
0.4 1.4 GO:0034764 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.3 3.0 GO:0070987 error-free translesion synthesis(GO:0070987)
0.3 2.0 GO:0016241 positive regulation of macroautophagy(GO:0016239) regulation of macroautophagy(GO:0016241)
0.3 2.7 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.3 1.6 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.3 0.9 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.3 3.4 GO:0016925 protein sumoylation(GO:0016925)
0.3 0.9 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.3 0.9 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.3 0.9 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 2.1 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.3 1.8 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.3 0.9 GO:0060194 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.3 2.5 GO:0046686 response to cadmium ion(GO:0046686)
0.3 1.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.3 5.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.3 0.8 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.3 11.6 GO:0009060 aerobic respiration(GO:0009060)
0.3 2.1 GO:0006119 oxidative phosphorylation(GO:0006119)
0.3 0.3 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.2 1.7 GO:0018345 protein palmitoylation(GO:0018345)
0.2 2.7 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.2 0.5 GO:0043270 positive regulation of ion transport(GO:0043270)
0.2 2.9 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.2 2.3 GO:0072348 sulfur compound transport(GO:0072348)
0.2 1.1 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.2 9.4 GO:0070726 cell wall assembly(GO:0070726)
0.2 1.3 GO:0006855 drug transmembrane transport(GO:0006855)
0.2 0.6 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.2 0.6 GO:0032079 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.2 0.8 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.2 0.4 GO:0042148 strand invasion(GO:0042148)
0.2 1.6 GO:0000755 cytogamy(GO:0000755)
0.2 1.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 1.0 GO:0051260 protein homooligomerization(GO:0051260)
0.2 3.4 GO:0000209 protein polyubiquitination(GO:0000209)
0.2 0.8 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.2 0.6 GO:0042407 cristae formation(GO:0042407)
0.2 0.4 GO:0018410 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.2 0.7 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.2 3.2 GO:0032258 CVT pathway(GO:0032258)
0.2 0.9 GO:0006265 DNA topological change(GO:0006265)
0.2 2.3 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.2 0.7 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.2 0.6 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.2 7.4 GO:0007031 peroxisome organization(GO:0007031)
0.2 1.4 GO:0043488 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.2 0.9 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.1 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.1 1.4 GO:0006813 potassium ion transport(GO:0006813)
0.1 2.3 GO:1905039 organic acid transmembrane transport(GO:1903825) carboxylic acid transmembrane transport(GO:1905039)
0.1 0.7 GO:0050821 protein stabilization(GO:0050821)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.3 GO:0006311 meiotic gene conversion(GO:0006311)
0.1 0.3 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 5.3 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 2.2 GO:0022900 electron transport chain(GO:0022900)
0.1 0.4 GO:0015793 glycerol transport(GO:0015793)
0.1 0.7 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.7 GO:0006452 translational frameshifting(GO:0006452)
0.1 1.4 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.1 0.8 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.2 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 1.0 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.4 GO:0019346 transsulfuration(GO:0019346)
0.1 0.3 GO:0051099 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of sulfur metabolic process(GO:0042762) positive regulation of DNA binding(GO:0043388) positive regulation of binding(GO:0051099) regulation of DNA binding(GO:0051101)
0.1 1.2 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.3 GO:0043096 purine nucleobase salvage(GO:0043096)
0.1 0.6 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.2 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1 1.4 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.5 GO:0051598 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.1 0.4 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 0.6 GO:0019395 fatty acid beta-oxidation(GO:0006635) fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.1 0.4 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.2 GO:0015867 ATP transport(GO:0015867)
0.1 0.4 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 0.2 GO:0015809 arginine transport(GO:0015809)
0.1 0.2 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.1 0.8 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.7 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753) cell morphogenesis involved in conjugation(GO:0000767)
0.1 0.1 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 1.4 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 0.2 GO:0090399 replicative senescence(GO:0090399)
0.1 1.0 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.1 0.3 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 0.3 GO:0015858 nucleoside transport(GO:0015858)
0.1 1.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1 0.3 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.1 0.4 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.4 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 0.3 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.2 GO:0071333 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.1 1.0 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.3 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.1 0.5 GO:0051294 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.1 0.5 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.1 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.1 GO:0060962 regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060962)
0.1 0.2 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.5 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.0 0.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.4 GO:0006826 iron ion transport(GO:0006826)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.3 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.2 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.9 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.4 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.0 0.2 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.0 0.1 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.0 0.1 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.1 GO:0009268 response to pH(GO:0009268)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.1 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.0 GO:0042727 flavin-containing compound metabolic process(GO:0042726) flavin-containing compound biosynthetic process(GO:0042727)
0.0 0.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.5 GO:0006631 fatty acid metabolic process(GO:0006631)
0.0 0.0 GO:0034030 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.0 0.1 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.4 GO:0034976 response to endoplasmic reticulum stress(GO:0034976)
0.0 0.0 GO:0045117 azole transport(GO:0045117)
0.0 0.1 GO:0009099 valine metabolic process(GO:0006573) valine biosynthetic process(GO:0009099)
0.0 0.1 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.0 0.1 GO:0007008 outer mitochondrial membrane organization(GO:0007008)
0.0 0.1 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.1 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.0 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.0 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.0 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.1 GO:0001300 chronological cell aging(GO:0001300)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 12.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
2.5 12.3 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
2.4 7.2 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
1.7 5.2 GO:0031166 integral component of vacuolar membrane(GO:0031166)
1.4 5.7 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
1.4 2.7 GO:0030061 mitochondrial crista(GO:0030061)
1.3 10.3 GO:0042597 periplasmic space(GO:0042597)
1.2 4.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.2 3.6 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
1.2 10.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.1 5.7 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
1.0 2.0 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
1.0 11.0 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.0 8.9 GO:0000328 fungal-type vacuole lumen(GO:0000328)
1.0 7.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.9 6.4 GO:0034657 GID complex(GO:0034657)
0.9 16.2 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.9 5.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.8 0.8 GO:0031931 TORC1 complex(GO:0031931)
0.7 9.7 GO:0070469 respiratory chain(GO:0070469)
0.7 8.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.7 2.2 GO:0001400 mating projection base(GO:0001400)
0.6 5.9 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.5 6.4 GO:0005619 ascospore wall(GO:0005619)
0.5 3.6 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.4 1.3 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.4 1.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.4 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.4 1.4 GO:0032116 SMC loading complex(GO:0032116)
0.3 2.1 GO:0033101 cellular bud membrane(GO:0033101)
0.3 15.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 0.6 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.3 15.1 GO:0031225 anchored component of membrane(GO:0031225)
0.3 0.9 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.3 1.8 GO:0008180 COP9 signalosome(GO:0008180)
0.3 4.5 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.3 46.5 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.3 1.1 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.3 0.3 GO:0005775 vacuolar lumen(GO:0005775)
0.2 0.5 GO:0044284 mitochondrial crista junction(GO:0044284)
0.2 4.4 GO:0005811 lipid particle(GO:0005811)
0.2 3.4 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.2 1.0 GO:0032221 Rpd3S complex(GO:0032221)
0.2 4.3 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.2 3.5 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.2 3.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 0.9 GO:0005869 dynactin complex(GO:0005869)
0.2 0.3 GO:0032126 eisosome(GO:0032126)
0.2 1.9 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.2 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 4.0 GO:0005770 late endosome(GO:0005770)
0.1 0.9 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 107.2 GO:0005739 mitochondrion(GO:0005739)
0.1 0.5 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 1.5 GO:0070822 Sin3-type complex(GO:0070822)
0.1 2.5 GO:0016592 mediator complex(GO:0016592)
0.1 1.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 0.5 GO:0033551 monopolin complex(GO:0033551)
0.1 0.7 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.8 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.5 GO:0019867 outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.1 0.3 GO:0005618 cell wall(GO:0005618) external encapsulating structure(GO:0030312)
0.1 1.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.3 GO:0000817 COMA complex(GO:0000817)
0.0 1.1 GO:0005576 extracellular region(GO:0005576)
0.0 0.2 GO:0097196 Shu complex(GO:0097196)
0.0 0.1 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.6 GO:0044438 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 0.4 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.0 GO:0000818 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 22.5 GO:0015295 solute:proton symporter activity(GO:0015295)
4.3 12.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
4.2 16.8 GO:0004396 hexokinase activity(GO:0004396)
4.2 12.5 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
2.9 11.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
2.7 8.0 GO:0016289 CoA hydrolase activity(GO:0016289)
2.6 7.9 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
2.5 9.9 GO:0005537 mannose binding(GO:0005537)
2.5 12.3 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
2.1 8.6 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
2.0 5.9 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.9 5.8 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.9 9.5 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.9 5.7 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.7 5.2 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.7 6.8 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.3 4.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
1.3 8.0 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.3 10.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.3 7.9 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.3 22.3 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
1.3 5.2 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
1.3 3.8 GO:0016405 AMP binding(GO:0016208) CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
1.2 17.3 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
1.2 4.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.1 7.9 GO:0004364 glutathione transferase activity(GO:0004364)
1.1 3.4 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
1.1 11.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.1 2.1 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.0 8.0 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.9 1.9 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.9 6.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.9 3.5 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.9 5.2 GO:0051213 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) dioxygenase activity(GO:0051213)
0.8 9.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.8 4.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.8 2.4 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.8 3.1 GO:0004180 carboxypeptidase activity(GO:0004180)
0.8 8.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.7 4.3 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.7 6.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.7 9.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.7 2.1 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.7 0.7 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.7 5.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.7 2.0 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.6 1.9 GO:0016872 intramolecular lyase activity(GO:0016872)
0.6 3.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.6 1.8 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.6 4.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.6 2.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.6 1.7 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.6 5.0 GO:0004888 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.6 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.6 6.1 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.5 1.1 GO:0048029 monosaccharide binding(GO:0048029)
0.5 1.5 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.5 1.5 GO:0070569 uridylyltransferase activity(GO:0070569)
0.5 2.4 GO:0008198 ferrous iron binding(GO:0008198)
0.5 3.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.5 34.6 GO:0051082 unfolded protein binding(GO:0051082)
0.4 1.3 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.4 1.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.4 2.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.4 2.1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.4 1.3 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.4 4.4 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.4 2.0 GO:0042171 lysophosphatidic acid acyltransferase activity(GO:0042171)
0.4 4.2 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.4 11.6 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.4 1.9 GO:0017022 myosin binding(GO:0017022)
0.4 3.2 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.3 1.0 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.3 2.7 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.3 0.7 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.3 3.3 GO:0031386 protein tag(GO:0031386)
0.3 0.6 GO:0045118 azole transporter activity(GO:0045118)
0.3 3.7 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.3 0.9 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.3 0.6 GO:0001097 RNA polymerase II basal transcription factor binding(GO:0001091) TFIIH-class transcription factor binding(GO:0001097)
0.3 0.3 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.3 2.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.3 2.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.3 4.0 GO:0015297 antiporter activity(GO:0015297)
0.2 0.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 2.9 GO:0022838 substrate-specific channel activity(GO:0022838)
0.2 3.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 1.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 1.1 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.2 0.9 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.2 1.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 4.8 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.2 2.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 1.0 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.2 2.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 2.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 0.4 GO:0015294 solute:cation symporter activity(GO:0015294)
0.2 0.9 GO:0008171 O-methyltransferase activity(GO:0008171)
0.2 0.9 GO:0070403 NAD+ binding(GO:0070403)
0.2 3.1 GO:0050661 NADP binding(GO:0050661)
0.2 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.5 GO:0019776 Atg8 ligase activity(GO:0019776)
0.2 2.0 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 0.4 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.9 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.3 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.4 GO:0004457 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.1 0.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 1.4 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.3 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 5.0 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.3 GO:0097027 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) ubiquitin-protein transferase activator activity(GO:0097027)
0.1 0.5 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 1.5 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.1 GO:0019902 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.1 1.5 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.3 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.1 0.2 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 0.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.4 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.9 GO:0017171 serine hydrolase activity(GO:0017171)
0.1 0.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 0.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 0.3 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 1.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.2 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 1.1 GO:0005509 calcium ion binding(GO:0005509)
0.1 3.5 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.1 1.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.5 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.5 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.1 0.3 GO:0004075 biotin carboxylase activity(GO:0004075)
0.0 0.3 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.2 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 1.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 2.8 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.5 GO:0005507 copper ion binding(GO:0005507)
0.0 0.3 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.6 GO:0016298 lipase activity(GO:0016298)
0.0 0.6 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0 0.2 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.6 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.6 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.2 GO:0016722 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions(GO:0016722) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.0 0.0 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.0 0.1 GO:0031683 receptor binding(GO:0005102) G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.8 4.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.7 2.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.6 1.8 PID FOXO PATHWAY FoxO family signaling
0.4 1.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4 1.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 1.0 PID NOTCH PATHWAY Notch signaling pathway
0.2 0.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.2 0.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.2 0.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 0.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.5 PID PLK1 PATHWAY PLK1 signaling events
0.1 86.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
2.0 21.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
1.0 3.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.4 0.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 0.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 0.5 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 1.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 80.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance