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Results for NDT80

Z-value: 1.88

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Transcription factors associated with NDT80

Gene Symbol Gene ID Gene Info
NDT80
S000001166 Meiosis-specific transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NDT80YHR124W0.846.4e-08Click!

Activity profile of NDT80 motif

Sorted Z-values of NDT80 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YLR307C-A 24.73 Putative protein of unknown function
YJL037W 22.63
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YMR107W 18.24
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YOR214C 18.21 Putative protein of unknown function; YOR214C is not an essential gene
YKR097W 14.41
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YPL223C 13.94
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YJL038C 13.28
LOH1
Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W
YAR053W 9.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL160C 9.27
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YDL210W 9.23
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YAR050W 8.31
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YPL021W 7.22
ECM23
Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
YER065C 7.10
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YMR244W 7.04 Putative protein of unknown function
YJL116C 6.82
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YMR017W 6.80
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YFL024C 6.80
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YBR051W 6.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YOL084W 6.70
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YFL012W 6.64 Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin
YLR142W 6.63
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YAL062W 6.55
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YAR047C 6.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFL011W 6.44
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YDR342C 6.41
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YBR050C 6.33
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YAR060C 6.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFL030W 6.29
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YBR072W 6.14
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YDR343C 6.02
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YKL031W 5.91 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YBR045C 5.76
GIP1
Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
YPL222W 5.76
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL202W 5.57
SPS19
Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
YOR023C 5.51
AHC1
Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
YPL033C 5.21 Putative protein of unknown function; may be involved in DNA metabolism; expression is induced by Kar4p
YIL155C 5.07
GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YLR308W 4.79
CDA2
Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YAL018C 4.74 Putative protein of unknown function
YIL066C 4.73
RNR3
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YFL051C 4.61 Putative protein of unknown function; YFL051C is not an essential gene
YLR356W 4.40 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YLR267W 4.32
BOP2
Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YER088C 4.30
DOT6
Protein of unknown function, involved in telomeric gene silencing and filamentation
YLR312C 4.28
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YJL043W 4.24 Putative protein of unknown function; YJL043W is a non-essential gene
YOR348C 4.12
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YGR243W 4.07
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR151C 4.05
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YLR122C 4.02 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YCR010C 3.99
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YIL107C 3.98
PFK26
6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A
YDR218C 3.89
SPR28
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
YOL047C 3.85 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YHR212C 3.79 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR027C 3.79 Putative protein of unknown function
YPL250C 3.79
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YFR023W 3.79
PES4
Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
YOL060C 3.73
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YGR059W 3.72
SPR3
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI
YLR054C 3.65
OSW2
Protein of unknown function proposed to be involved in the assembly of the spore wall
YBR250W 3.62
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YOL085W-A 3.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YGL163C 3.56
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YER103W 3.55
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YOR338W 3.53 Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen
YFL012W-A 3.50 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C
YDR317W 3.48
HIM1
Protein of unknown function involved in DNA repair
YNL018C 3.45 Putative protein of unknown function
YLR123C 3.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YJL166W 3.39
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YHR212W-A 3.32 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YNL318C 3.31
HXT14
Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR402W 3.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR339C 3.27
UBC11
Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2
YGR043C 3.27
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YLR403W 3.23
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YFL013C 3.21
IES1
Subunit of the INO80 chromatin remodeling complex
YLR149C 3.20 Putative protein of unknown function; YLR149C is not an essential gene
YCL054W 3.19
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YLR327C 3.18
TMA10
Protein of unknown function that associates with ribosomes
YGR110W 3.16 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YBR076W 3.14
ECM8
Non-essential protein of unknown function
YBL015W 3.12
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YOL163W 3.11 Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
YDR042C 3.10 Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
YDR096W 3.09
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YOR345C 3.08 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YER106W 3.05
MAM1
Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
YOR346W 3.03
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YLR136C 2.95
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YGL183C 2.94
MND1
Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks
YHR211W 2.94
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YOR192C 2.93
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YHR048W 2.92
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YDR529C 2.86
QCR7
Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
YOR343C 2.82 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGR201C 2.81 Putative protein of unknown function
YLR124W 2.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR144W 2.77
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YBR056W-A 2.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YPL092W 2.75
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YHR145C 2.74 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL039C 2.72
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YHR015W 2.70
MIP6
Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YGL170C 2.68
SPO74
Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
YOR192C-C 2.66 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YLR228C 2.64
ECM22
Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YDR271C 2.57 Hypothetical protein
YIL113W 2.56
SDP1
Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
YDR114C 2.56 Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
YNR063W 2.56 Putative zinc-cluster protein of unknown function
YOR072W 2.53 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YBL096C 2.51 Non-essential protein of unknown function
YOR373W 2.50
NUD1
Component of the spindle pole body outer plaque, required for exit from mitosis
YOR372C 2.49
NDD1
Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes
YMR165C 2.47
PAH1
Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
YML131W 2.46 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YGR191W 2.45
HIP1
High-affinity histidine permease, also involved in the transport of manganese ions
YLR125W 2.44 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YDR277C 2.43
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YHR097C 2.40 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YDR542W 2.39
PAU10
Hypothetical protein
YDR055W 2.38
PST1
Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YLR152C 2.37 Putative protein of unknown function; YLR152C is not an essential gene
YFL023W 2.34
BUD27
Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by TOR kinase; diploid mutants show a random budding pattern rather than the wild-type bipolar pattern; plays a role in regulating Ty1 transposition
YBL095W 2.29 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR190W 2.27
SPR1
Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
YMR206W 2.26 Putative protein of unknown function; YMR206W is not an essential gene
YJR146W 2.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YPL189C-A 2.24
COA2
Putative cytochrome oxidase assembly factor; identified by homology to Ashbya gossypii; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity
YJR120W 2.24 Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YIR014W 2.23 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene
YBR180W 2.21
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YPL206C 2.20
PGC1
Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs
YLR213C 2.19
CRR1
Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
YBR179C 2.15
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YGR070W 2.14
ROM1
GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YKL032C 2.12
IXR1
Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YLR111W 2.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR034C 2.08
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YKR101W 2.07
SIR1
Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
YEL059W 2.07 Dubious open reading frame unlikely to encode a functional protein
YDR438W 2.06
THI74
Mitochondrial transporter repressible by thiamine
YOR024W 2.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR270C 2.05
BIT2
Hypothetical protein
YOR290C 2.02
SNF2
Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
YLR395C 2.02
COX8
Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YCR007C 2.02 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YNL196C 1.99
SLZ1
Sporulation-specific protein with a leucine zipper motif
YDR281C 1.98
PHM6
Protein of unknown function, expression is regulated by phosphate levels
YJR150C 1.98
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YDR173C 1.96
ARG82
Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
YNL033W 1.96 Putative protein of unknown function
YOR031W 1.96
CRS5
Copper-binding metallothionein, required for wild-type copper resistance
YOR071C 1.95
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YDR505C 1.91
PSP1
Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition
YHR184W 1.90
SSP1
Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis
YJR107W 1.89 Putative protein of unknown function; has sequence or structural similarity to lipases
YDL109C 1.86 Putative lipase; involved in lipid metabolism; YDL109C is not an essential gene
YAR035W 1.85
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YDR273W 1.85
DON1
Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
YLL019C 1.84
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YKL067W 1.83
YNK1
Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YER085C 1.82 Putative protein of unknown function
YGR190C 1.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YLR375W 1.81
STP3
Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YAL063C 1.81
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YOR178C 1.80
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YPR013C 1.78 Putative zinc finger protein; YPR013C is not an essential gene
YLR374C 1.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
YJR048W 1.78
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YKL044W 1.75 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR141C 1.75
KAR3
Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate
YCL001W-B 1.73 Putative protein of unknown function; identified by homology
YDL181W 1.72
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YGL073W 1.72
HSF1
Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
YAL017W 1.70
PSK1
One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
YKR100C 1.70
SKG1
Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
YGL117W 1.69 Putative protein of unknown function
YNL019C 1.69 Putative protein of unknown function
YGL121C 1.68
GPG1
Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p
YOR072W-A 1.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YGL249W 1.67
ZIP2
Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis
YML066C 1.67
SMA2
Protein of unknown function involved in the assembly of the prospore membrane during sporulation
YOR100C 1.66
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YDL204W 1.66
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YAL067C 1.65
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YDR148C 1.65
KGD2
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
YGR268C 1.63
HUA1
Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YNL017C 1.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the tRNA ORF tI(AAU)N2
YIL144W 1.62
TID3
Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
YBR201C-A 1.61 Putative protein of unknown function
YJL045W 1.60 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YGL015C 1.60 Hypothetical protein
YDR115W 1.56 Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins
YDR014W-A 1.55
HED1
Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YLL039C 1.55
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YBR292C 1.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YMR118C 1.54 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene

Network of associatons between targets according to the STRING database.

First level regulatory network of NDT80

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 14.9 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
2.2 8.9 GO:0015847 putrescine transport(GO:0015847)
2.2 6.6 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
2.2 6.5 GO:0006545 glycine biosynthetic process(GO:0006545)
1.9 5.7 GO:0015888 thiamine transport(GO:0015888)
1.6 4.7 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.4 4.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
1.4 4.1 GO:0006850 mitochondrial pyruvate transport(GO:0006850)
1.1 4.6 GO:0015804 neutral amino acid transport(GO:0015804)
1.0 24.5 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
1.0 7.1 GO:0006097 glyoxylate cycle(GO:0006097)
1.0 5.1 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.9 3.7 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.9 3.7 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.9 2.7 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.9 6.2 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.9 4.3 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.9 1.7 GO:0032006 regulation of TOR signaling(GO:0032006)
0.8 15.8 GO:0009062 fatty acid catabolic process(GO:0009062)
0.8 2.5 GO:0045117 azole transport(GO:0045117)
0.8 0.8 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.8 8.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.8 2.3 GO:0042148 strand invasion(GO:0042148)
0.7 3.0 GO:0034389 lipid particle organization(GO:0034389)
0.7 2.2 GO:0070583 spore membrane bending pathway(GO:0070583)
0.7 2.2 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.7 4.3 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.7 2.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.7 2.1 GO:0071456 cellular response to hypoxia(GO:0071456)
0.7 2.1 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.7 2.1 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.7 2.0 GO:0000821 regulation of glutamine family amino acid metabolic process(GO:0000820) regulation of arginine metabolic process(GO:0000821)
0.6 2.6 GO:0000200 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.6 2.5 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.6 1.9 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.6 2.4 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.6 2.3 GO:0072369 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.6 1.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.6 3.4 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.6 6.8 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.5 0.5 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.5 1.6 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.5 3.7 GO:0006083 acetate metabolic process(GO:0006083)
0.5 2.1 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.5 2.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.5 3.5 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.5 1.0 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.5 2.4 GO:0006032 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.5 0.5 GO:0001666 response to hypoxia(GO:0001666)
0.4 0.4 GO:0006110 regulation of glycolytic process(GO:0006110)
0.4 2.9 GO:0070987 error-free translesion synthesis(GO:0070987)
0.4 1.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.4 1.6 GO:0019748 secondary metabolic process(GO:0019748)
0.4 0.8 GO:0071467 cellular response to pH(GO:0071467)
0.4 1.1 GO:0061727 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.4 11.7 GO:0006094 gluconeogenesis(GO:0006094)
0.4 1.1 GO:0044209 AMP salvage(GO:0044209)
0.4 3.3 GO:0072348 sulfur compound transport(GO:0072348)
0.4 2.9 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.4 1.1 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.4 3.2 GO:0031167 rRNA methylation(GO:0031167)
0.4 3.5 GO:0042766 nucleosome mobilization(GO:0042766)
0.3 1.0 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.3 1.7 GO:0043954 cellular component maintenance(GO:0043954)
0.3 12.4 GO:0070591 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.3 4.3 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.3 1.0 GO:0051865 protein autoubiquitination(GO:0051865)
0.3 2.9 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.3 3.5 GO:0015696 ammonium transport(GO:0015696)
0.3 1.3 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.3 5.4 GO:0006513 protein monoubiquitination(GO:0006513)
0.3 1.2 GO:0051099 positive regulation of binding(GO:0051099)
0.3 0.9 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.3 2.1 GO:0015851 nucleobase transport(GO:0015851)
0.3 0.3 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.3 2.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 2.6 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.3 1.4 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3 1.1 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.3 3.1 GO:0015893 drug transport(GO:0015893)
0.3 0.8 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.3 0.6 GO:1903321 negative regulation of protein ubiquitination(GO:0031397) negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of protein modification by small protein conjugation or removal(GO:1903321)
0.3 0.8 GO:0008105 asymmetric protein localization(GO:0008105)
0.3 1.1 GO:0015793 glycerol transport(GO:0015793)
0.3 0.5 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.3 1.3 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.3 1.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.3 1.3 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.3 0.8 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.3 1.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.3 1.8 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.2 1.2 GO:0006279 premeiotic DNA replication(GO:0006279)
0.2 0.5 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.2 1.0 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.2 3.7 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.2 5.4 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.2 1.1 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.2 1.5 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.2 0.6 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.2 0.6 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.2 2.3 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.2 1.0 GO:0000023 maltose metabolic process(GO:0000023)
0.2 2.2 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.2 1.7 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 2.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 0.2 GO:0051606 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.2 0.7 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.2 0.4 GO:0043270 positive regulation of ion transport(GO:0043270)
0.2 0.2 GO:0046185 aldehyde catabolic process(GO:0046185)
0.2 0.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.2 0.4 GO:0006108 malate metabolic process(GO:0006108)
0.2 0.9 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.2 0.9 GO:0030007 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.2 0.2 GO:0043937 regulation of sporulation(GO:0043937)
0.2 0.7 GO:0006598 polyamine catabolic process(GO:0006598)
0.2 0.5 GO:0030308 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.2 0.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 2.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.2 0.5 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 0.5 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.2 1.8 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.2 1.2 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.2 0.8 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.2 13.1 GO:0030435 sporulation resulting in formation of a cellular spore(GO:0030435)
0.2 1.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 0.5 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.2 0.5 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.2 1.6 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.2 0.8 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.2 0.8 GO:0035376 sterol import(GO:0035376)
0.2 0.5 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.1 0.6 GO:0019346 transsulfuration(GO:0019346)
0.1 0.4 GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress(GO:0061408)
0.1 0.4 GO:0042743 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.1 3.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 0.4 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.8 GO:0006449 regulation of translational termination(GO:0006449)
0.1 0.8 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.1 0.7 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.1 2.5 GO:0010038 response to metal ion(GO:0010038)
0.1 0.1 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.1 0.9 GO:0071459 protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
0.1 0.9 GO:0006801 superoxide metabolic process(GO:0006801)
0.1 0.9 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 5.1 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.2 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.1 1.1 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.6 GO:0045815 negative regulation of chromatin silencing(GO:0031936) positive regulation of gene expression, epigenetic(GO:0045815) negative regulation of gene silencing(GO:0060969)
0.1 0.4 GO:0050685 positive regulation of mRNA processing(GO:0050685)
0.1 0.5 GO:0045471 response to ethanol(GO:0045471)
0.1 0.6 GO:0032973 amino acid export(GO:0032973) amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.1 0.5 GO:0015937 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.1 0.7 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.4 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.1 1.3 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.1 1.0 GO:0006826 iron ion transport(GO:0006826)
0.1 0.1 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.1 0.3 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.1 0.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.4 GO:1901925 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 0.6 GO:0045116 protein neddylation(GO:0045116)
0.1 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.1 1.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.3 GO:0046503 glycerolipid catabolic process(GO:0046503)
0.1 0.6 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.1 0.1 GO:0070482 response to decreased oxygen levels(GO:0036293) response to oxygen levels(GO:0070482)
0.1 0.4 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 0.6 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.2 GO:0010672 regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010672)
0.1 0.3 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.1 0.4 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.1 0.5 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.4 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.1 1.0 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 2.8 GO:0016573 histone acetylation(GO:0016573)
0.1 0.9 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835) negative regulation of meiotic cell cycle(GO:0051447)
0.1 0.2 GO:0015883 FAD transport(GO:0015883)
0.1 0.3 GO:0000090 mitotic anaphase(GO:0000090)
0.1 0.5 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.1 0.6 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.4 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 0.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.2 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.5 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.2 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.6 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.8 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 0.2 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.1 0.2 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.1 0.2 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 1.1 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:2001040 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.4 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.5 GO:0006031 aminoglycan biosynthetic process(GO:0006023) chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.0 0.3 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.2 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.0 0.1 GO:0031111 negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0 0.1 GO:0008216 spermidine metabolic process(GO:0008216)
0.0 3.6 GO:0006457 protein folding(GO:0006457)
0.0 0.2 GO:0032978 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979)
0.0 0.1 GO:0009268 response to pH(GO:0009268)
0.0 0.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.0 0.2 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.0 0.1 GO:0036257 multivesicular body organization(GO:0036257)
0.0 0.0 GO:0032205 negative regulation of telomere maintenance(GO:0032205) negative regulation of homeostatic process(GO:0032845)
0.0 0.0 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.2 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.0 0.1 GO:0006452 translational frameshifting(GO:0006452)
0.0 0.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) regulation of transcription initiation from RNA polymerase II promoter(GO:0060260) regulation of DNA-templated transcription, initiation(GO:2000142)
0.0 0.6 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.0 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0070941 eisosome assembly(GO:0070941)
0.0 0.2 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0019932 second-messenger-mediated signaling(GO:0019932)
0.0 0.4 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.1 GO:0009106 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.0 0.0 GO:0070550 rDNA condensation(GO:0070550)
0.0 0.1 GO:0006529 asparagine metabolic process(GO:0006528) asparagine biosynthetic process(GO:0006529)
0.0 0.1 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 13.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.2 14.8 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.1 6.8 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
1.1 14.6 GO:0005619 ascospore wall(GO:0005619)
0.8 5.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.8 18.9 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.7 2.9 GO:0033551 monopolin complex(GO:0033551)
0.7 6.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.7 2.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.5 1.6 GO:0045252 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.5 1.0 GO:0001400 mating projection base(GO:0001400)
0.3 1.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.3 1.6 GO:0031262 Ndc80 complex(GO:0031262)
0.3 3.8 GO:0031011 Ino80 complex(GO:0031011)
0.3 4.8 GO:0033698 Rpd3L complex(GO:0033698)
0.3 2.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.3 1.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 0.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 0.9 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.3 1.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 1.9 GO:0016272 prefoldin complex(GO:0016272)
0.3 2.3 GO:0000795 synaptonemal complex(GO:0000795)
0.3 11.3 GO:0031225 anchored component of membrane(GO:0031225)
0.2 0.7 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.2 0.7 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.2 2.5 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.2 2.0 GO:0070069 cytochrome complex(GO:0070069)
0.2 0.8 GO:0000815 ESCRT III complex(GO:0000815)
0.2 1.8 GO:0070469 respiratory chain(GO:0070469)
0.2 0.6 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.2 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.2 1.3 GO:0033101 cellular bud membrane(GO:0033101)
0.2 0.7 GO:0008623 CHRAC(GO:0008623)
0.2 1.2 GO:0034967 Set3 complex(GO:0034967)
0.2 0.5 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.2 0.5 GO:0032177 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.2 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.9 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.7 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.1 2.4 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.5 GO:0000817 COMA complex(GO:0000817)
0.1 0.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 5.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.4 GO:0033309 SBF transcription complex(GO:0033309)
0.1 1.5 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 0.8 GO:0034657 GID complex(GO:0034657)
0.1 19.1 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 3.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.2 GO:0005845 mRNA cap binding complex(GO:0005845)
0.1 1.4 GO:0005682 U5 snRNP(GO:0005682)
0.1 1.1 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 1.5 GO:0070847 core mediator complex(GO:0070847)
0.1 0.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.6 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.3 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 1.9 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 50.9 GO:0005739 mitochondrion(GO:0005739)
0.1 0.2 GO:0032116 SMC loading complex(GO:0032116)
0.1 0.5 GO:0097346 INO80-type complex(GO:0097346)
0.0 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.2 GO:0000144 cellular bud neck septin ring(GO:0000144)
0.0 0.2 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:0098589 membrane region(GO:0098589)
0.0 0.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.9 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 0.1 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.2 GO:0008023 transcription elongation factor complex(GO:0008023)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 14.6 GO:0005537 mannose binding(GO:0005537)
3.1 9.2 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
2.1 6.4 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
1.4 5.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.4 4.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
1.4 5.5 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.4 4.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.2 7.0 GO:0016408 C-acyltransferase activity(GO:0016408)
1.2 6.9 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
1.1 3.3 GO:1901474 azole transmembrane transporter activity(GO:1901474)
1.0 3.1 GO:0016289 CoA hydrolase activity(GO:0016289)
1.0 3.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.9 17.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.9 6.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.9 8.1 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.9 6.0 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.9 2.6 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.8 3.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.8 6.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.8 7.0 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.7 0.7 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.7 2.2 GO:0004629 phospholipase C activity(GO:0004629)
0.7 4.3 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.7 2.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.7 2.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.6 1.9 GO:0016417 S-acyltransferase activity(GO:0016417)
0.6 3.2 GO:0008198 ferrous iron binding(GO:0008198)
0.6 1.9 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.6 5.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.6 0.6 GO:0032452 histone demethylase activity(GO:0032452)
0.6 1.1 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.5 3.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.5 1.9 GO:0004396 hexokinase activity(GO:0004396)
0.5 12.7 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.4 7.3 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 1.5 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.4 4.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.4 4.1 GO:0015103 inorganic anion transmembrane transporter activity(GO:0015103)
0.4 1.1 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.3 1.0 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.3 1.3 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.3 1.0 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.3 4.3 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.3 0.9 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.3 1.4 GO:0017022 myosin binding(GO:0017022)
0.3 0.9 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.3 0.6 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.3 0.3 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.3 0.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 2.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 0.9 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.2 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 1.1 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.2 0.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 1.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 3.5 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.2 1.7 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.2 0.6 GO:0016655 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 1.0 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.2 3.3 GO:0015616 DNA translocase activity(GO:0015616)
0.2 2.0 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 1.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 2.2 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.2 4.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 1.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.2 0.7 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.2 3.2 GO:0015297 antiporter activity(GO:0015297)
0.2 1.2 GO:0015293 symporter activity(GO:0015293)
0.2 0.5 GO:0030332 cyclin binding(GO:0030332)
0.2 1.9 GO:0005507 copper ion binding(GO:0005507)
0.1 0.9 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.4 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 1.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.3 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.1 0.7 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.5 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 6.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.5 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.4 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.1 0.5 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.4 GO:0032183 SUMO binding(GO:0032183)
0.1 2.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.4 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 0.4 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.1 1.4 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 3.1 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 8.4 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.5 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 2.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.9 GO:0016722 oxidoreductase activity, oxidizing metal ions(GO:0016722)
0.1 0.4 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 0.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 0.6 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.1 0.3 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 0.4 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.7 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 0.2 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 0.5 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 1.5 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 1.1 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.3 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.3 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 0.2 GO:0004930 G-protein coupled receptor activity(GO:0004930) glucose binding(GO:0005536)
0.1 0.9 GO:0008301 DNA binding, bending(GO:0008301)
0.1 3.9 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.1 0.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 1.2 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.1 0.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.5 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.1 0.3 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.1 1.1 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.1 0.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.5 GO:0034212 peptide N-acetyltransferase activity(GO:0034212)
0.0 0.4 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.0 0.6 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.2 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.0 0.1 GO:0016885 biotin carboxylase activity(GO:0004075) ligase activity, forming carbon-carbon bonds(GO:0016885)
0.0 1.2 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.5 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.2 GO:0017171 serine hydrolase activity(GO:0017171)
0.0 0.4 GO:0022804 active transmembrane transporter activity(GO:0022804)
0.0 0.2 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.6 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.0 0.0 GO:0045118 azole transporter activity(GO:0045118)
0.0 0.1 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163)
0.0 0.1 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.0 0.2 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138) ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.8 2.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.5 0.5 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.5 0.5 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.2 1.1 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.2 1.0 PID P73PATHWAY p73 transcription factor network
0.2 0.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 161.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
1.8 14.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.6 1.8 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.4 3.6 REACTOME MEIOSIS Genes involved in Meiosis
0.3 1.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.3 3.1 REACTOME DNA REPAIR Genes involved in DNA Repair
0.3 0.3 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.2 0.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 0.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.4 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 151.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 0.1 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.0 0.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives