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Results for OAF1

Z-value: 1.94

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Transcription factors associated with OAF1

Gene Symbol Gene ID Gene Info
OAF1
S000000048 Oleate-activated transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
OAF1YAL051W0.854.5e-08Click!

Activity profile of OAF1 motif

Sorted Z-values of OAF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YJR095W 27.81
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YLR174W 22.88
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YJL045W 21.55 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YNR002C 19.96
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YIL057C 19.32 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YJR048W 18.73
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YLR377C 18.54
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YOR348C 16.95
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YJL116C 16.58
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YFR053C 15.86
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YNL117W 15.77
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YOR343C 15.52 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDR119W-A 15.14 Putative protein of unknown function
YPL223C 15.05
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YML042W 14.61
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YLR307C-A 13.35 Putative protein of unknown function
YNL202W 12.89
SPS19
Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
YKR009C 12.27
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YFL051C 12.23 Putative protein of unknown function; YFL051C is not an essential gene
YDR536W 12.19
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YPL171C 11.96
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YNR034W-A 11.93 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YPL024W 11.28
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YGR243W 11.20
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAL039C 10.85
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YPL026C 10.53
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YKL109W 10.41
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YLR356W 10.29 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YCR005C 10.28
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YDR277C 10.04
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YBL043W 10.01
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YBL015W 9.87
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YFL030W 9.29
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YOL084W 8.88
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YPR002W 8.83
PDH1
Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YPR001W 8.43
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YNL144C 8.31 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YMR244W 8.20 Putative protein of unknown function
YHR139C 8.04
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YKL217W 8.00
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YML089C 7.83 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YOR192C 7.56
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YEL012W 7.52
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YOR382W 7.46
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOR072W 7.38 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YAR053W 7.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR192C-C 7.37 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YMR206W 7.36 Putative protein of unknown function; YMR206W is not an essential gene
YDR298C 7.25
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YOL052C-A 7.23
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YOR393W 7.14
ERR1
Protein of unknown function, has similarity to enolases
YKR097W 7.01
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YGR110W 6.93 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YLL019C 6.84
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YPR151C 6.79
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YKL028W 6.56
TFA1
TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YPL147W 6.54
PXA1
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YDR216W 6.49
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YLL041C 6.48
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YNL274C 6.47
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR421W 6.41
ARO80
Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
YGR067C 6.40 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YOR388C 6.38
FDH1
NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
YER015W 6.25
FAA2
Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids
YKR015C 6.25 Putative protein of unknown function
YPR196W 6.23 Putative maltose activator
YMR103C 6.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR070C 6.15
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL222W 6.13
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL142W 6.11
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YDR343C 6.11
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YOR381W 6.09
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YAR069C 6.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR081C 6.08
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YBR297W 6.04
MAL33
MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YOR100C 6.04
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YOR071C 6.00
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YPL135W 5.96
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YPL017C 5.94
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YHR048W 5.92
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YOR072W-A 5.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YHR212C 5.73 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR406W 5.61
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YAR070C 5.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR152C 5.59 Putative protein of unknown function; YLR152C is not an essential gene
YHR211W 5.54
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YPL201C 5.45
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YDL223C 5.44
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YHR212W-A 5.41 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLL053C 5.40 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YPL186C 5.39
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YOR065W 5.36
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YML081C-A 5.34
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YMR104C 5.33
YPK2
Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YGR144W 5.33
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YCR007C 5.27 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YPR150W 5.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YIL160C 5.23
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YAR060C 5.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL222C 5.17
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YEL009C 5.15
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YLR122C 5.15 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YEL008W 5.14 Hypothetical protein predicted to be involved in metabolism
YDL244W 5.09
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YMR017W 5.06
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YHL024W 4.97
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YJR152W 4.94
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YDR250C 4.90 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YGR045C 4.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR061C 4.87
JID1
Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YDR043C 4.86
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YFL054C 4.82 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YLL052C 4.79
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YPL185W 4.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YPL181W 4.78
CTI6
Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YOR391C 4.77
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YBL064C 4.77
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YPR013C 4.76 Putative zinc finger protein; YPR013C is not an essential gene
YJL127C-B 4.76 Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
YML090W 4.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YJL217W 4.72 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YGR256W 4.69
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YDR251W 4.66
PAM1
Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
YNL180C 4.66
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YBR072W 4.66
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YHR160C 4.65
PEX18
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
YLR296W 4.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR120W 4.62
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YOR223W 4.61 Putative protein of unknown function
YAL018C 4.60 Putative protein of unknown function
YOL085W-A 4.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YOR389W 4.54 Putative protein of unknown function; expression regulated by copper levels
YIR029W 4.52
DAL2
Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YPR023C 4.50
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YNL143C 4.50 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL182C 4.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
YBR179C 4.45
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YLR123C 4.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YDL214C 4.39
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YDR377W 4.38
ATP17
Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YNL179C 4.37 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YLR327C 4.30
TMA10
Protein of unknown function that associates with ribosomes
YER158C 4.28 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YDR441C 4.26
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YEL028W 4.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL096C 4.23 Non-essential protein of unknown function
YIL077C 4.21 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YDR342C 4.20
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YDL246C 4.16
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YDR249C 4.10 Putative protein of unknown function
YCR021C 4.06
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YJL161W 4.02
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAR068W 4.01 Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YJR078W 4.00
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YFR029W 4.00
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YBL095W 3.99 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL025C 3.99 Hypothetical protein
YKR040C 3.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YGL205W 3.98
POX1
Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YLR402W 3.94 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR016W 3.91
AIM28
Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media
YFL052W 3.90 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YMR090W 3.88 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YGR288W 3.87
MAL13
MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
YML091C 3.85
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YAR050W 3.83
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YGL258W-A 3.82 Putative protein of unknown function
YCL001W-B 3.81 Putative protein of unknown function; identified by homology
YIR039C 3.79
YPS6
Putative GPI-anchored aspartic protease
YNL242W 3.76
ATG2
Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the pre-autophagosomal structure and mitochondria
YLR403W 3.75
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YJR160C 3.72
MPH3
Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YLR295C 3.71
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YBR180W 3.69
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YJR159W 3.68
SOR1
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YDL194W 3.66
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YER033C 3.66
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YER065C 3.62
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YOR152C 3.58 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YKL029C 3.58
MAE1
Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
YLR124W 3.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL185C 3.56 Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene
YNL055C 3.56
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YKR102W 3.54
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YNL194C 3.52 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YIR027C 3.52
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YGL192W 3.46
IME4
Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YGL053W 3.46
PRM8
Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
YGL193C 3.46 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YOR011W-A 3.43 Putative protein of unknown function
YEL074W 3.41 Hypothetical protein
YHL021C 3.41
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YDL114W 3.40 Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
YOR363C 3.39
PIP2
Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes
YNL190W 3.33 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YMR110C 3.33
HFD1
Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome
YHR095W 3.33 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR287W 3.32
INM2
Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
YFL053W 3.30
DAK2
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YOR208W 3.25
PTP2
Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus

Network of associatons between targets according to the STRING database.

First level regulatory network of OAF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.3 27.8 GO:0015740 C4-dicarboxylate transport(GO:0015740)
6.4 19.1 GO:0015755 fructose transport(GO:0015755)
6.2 61.7 GO:0046487 glyoxylate metabolic process(GO:0046487)
6.1 18.4 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
5.9 17.6 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
4.8 19.2 GO:0006848 pyruvate transport(GO:0006848)
4.7 14.0 GO:0015888 thiamine transport(GO:0015888)
4.4 17.6 GO:0015804 neutral amino acid transport(GO:0015804)
3.6 10.9 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
3.3 9.9 GO:0046321 regulation of fatty acid beta-oxidation(GO:0031998) positive regulation of fatty acid beta-oxidation(GO:0032000) regulation of fatty acid oxidation(GO:0046320) positive regulation of fatty acid oxidation(GO:0046321)
3.1 9.3 GO:0006545 glycine biosynthetic process(GO:0006545)
3.0 30.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
2.9 11.7 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
2.7 2.7 GO:0051099 positive regulation of binding(GO:0051099)
2.6 7.9 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
2.6 28.5 GO:0009062 fatty acid catabolic process(GO:0009062)
2.3 11.6 GO:0015793 glycerol transport(GO:0015793)
2.1 14.9 GO:0000023 maltose metabolic process(GO:0000023)
2.1 2.1 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
2.1 12.7 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
2.1 6.3 GO:0072488 ammonium transmembrane transport(GO:0072488)
2.0 13.8 GO:0006083 acetate metabolic process(GO:0006083)
1.9 5.8 GO:0006572 tyrosine catabolic process(GO:0006572)
1.9 9.4 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.8 5.4 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
1.8 5.4 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
1.8 14.3 GO:0015891 siderophore transport(GO:0015891)
1.7 10.1 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
1.7 23.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
1.6 6.6 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
1.6 19.3 GO:0019740 nitrogen utilization(GO:0019740)
1.6 9.5 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
1.5 4.6 GO:0042843 D-xylose catabolic process(GO:0042843)
1.5 13.3 GO:0009749 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
1.5 4.4 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
1.4 5.6 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
1.4 23.3 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
1.4 4.1 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.4 10.8 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
1.3 9.2 GO:0016239 positive regulation of macroautophagy(GO:0016239)
1.3 3.8 GO:0006108 malate metabolic process(GO:0006108)
1.3 2.5 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
1.2 5.8 GO:0008053 mitochondrial fusion(GO:0008053)
1.1 4.5 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
1.1 3.2 GO:1903137 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
1.1 8.5 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.0 2.1 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
1.0 5.2 GO:0060211 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196) regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
1.0 4.0 GO:0043200 response to amino acid(GO:0043200)
0.9 2.8 GO:0005993 trehalose catabolic process(GO:0005993)
0.9 5.5 GO:0006279 premeiotic DNA replication(GO:0006279)
0.9 2.7 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.9 2.7 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.9 4.5 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.9 5.4 GO:0043457 regulation of cellular respiration(GO:0043457)
0.9 4.4 GO:0016562 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.9 6.2 GO:0015908 fatty acid transport(GO:0015908)
0.9 2.6 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.9 3.4 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.8 4.2 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.8 4.2 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.8 6.7 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.8 1.6 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.8 3.2 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.8 3.9 GO:0044070 regulation of anion transport(GO:0044070)
0.8 3.1 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.8 13.0 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.8 3.8 GO:0009251 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.7 0.7 GO:0006538 glutamate catabolic process(GO:0006538)
0.7 4.9 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.7 2.8 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.7 3.5 GO:0070941 eisosome assembly(GO:0070941)
0.7 8.9 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.7 6.7 GO:0046686 response to cadmium ion(GO:0046686)
0.7 2.6 GO:0006598 polyamine catabolic process(GO:0006598)
0.6 4.5 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.6 1.9 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.6 9.3 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.6 13.3 GO:0008219 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.6 1.2 GO:0071941 urea metabolic process(GO:0019627) nitrogen cycle metabolic process(GO:0071941)
0.6 1.2 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.6 1.1 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.5 3.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.5 2.1 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.5 2.6 GO:0072337 modified amino acid transport(GO:0072337)
0.5 1.5 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.5 7.0 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.5 1.5 GO:0019321 pentose metabolic process(GO:0019321) pentose catabolic process(GO:0019323)
0.5 3.0 GO:0000266 mitochondrial fission(GO:0000266)
0.5 2.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.5 1.4 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.4 1.3 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.4 1.8 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.4 1.2 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.4 1.6 GO:0016241 regulation of macroautophagy(GO:0016241)
0.4 2.3 GO:0015851 nucleobase transport(GO:0015851)
0.4 2.3 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.4 7.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.4 1.9 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.4 4.5 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.4 5.1 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.4 1.1 GO:0008105 asymmetric protein localization(GO:0008105)
0.4 1.5 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.4 16.3 GO:0009060 aerobic respiration(GO:0009060)
0.3 1.0 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.3 3.4 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.3 2.0 GO:0018065 protein-cofactor linkage(GO:0018065)
0.3 1.0 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.3 4.6 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.3 0.3 GO:0000304 response to singlet oxygen(GO:0000304)
0.3 1.0 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.3 5.8 GO:0006094 gluconeogenesis(GO:0006094)
0.3 1.0 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.3 1.0 GO:0015809 arginine transport(GO:0015809)
0.3 0.9 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.3 1.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 0.9 GO:0006546 glycine catabolic process(GO:0006546)
0.3 3.0 GO:0015893 drug transport(GO:0015893)
0.3 1.4 GO:0046464 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.3 2.9 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.3 0.9 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.3 1.9 GO:0045332 phospholipid translocation(GO:0045332)
0.3 10.5 GO:0010927 cellular component assembly involved in morphogenesis(GO:0010927) ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.3 3.2 GO:0051447 negative regulation of meiotic nuclear division(GO:0045835) negative regulation of meiotic cell cycle(GO:0051447)
0.3 0.5 GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of conjugation with cellular fusion(GO:0031137) regulation of multi-organism process(GO:0043900) regulation of conjugation(GO:0046999) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238)
0.3 0.8 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.3 0.5 GO:0032006 regulation of TOR signaling(GO:0032006)
0.3 1.3 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.3 1.6 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.3 1.5 GO:0009306 protein secretion(GO:0009306)
0.3 0.5 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.2 0.5 GO:0008216 spermidine metabolic process(GO:0008216)
0.2 0.5 GO:0031297 replication fork processing(GO:0031297)
0.2 1.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.2 1.4 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.2 0.2 GO:0006311 meiotic gene conversion(GO:0006311)
0.2 2.0 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.2 0.9 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.2 0.6 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.2 1.4 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.2 0.2 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.2 0.8 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.2 2.8 GO:0042493 response to drug(GO:0042493)
0.2 1.0 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.2 0.9 GO:0009208 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.2 0.2 GO:0030048 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.2 3.5 GO:0006312 mitotic recombination(GO:0006312)
0.2 0.3 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.2 3.5 GO:0016579 protein deubiquitination(GO:0016579)
0.2 1.0 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.2 4.5 GO:0007031 peroxisome organization(GO:0007031)
0.2 1.9 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.2 1.6 GO:0007129 synapsis(GO:0007129)
0.2 0.5 GO:0071850 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.1 0.3 GO:0006824 cobalt ion transport(GO:0006824)
0.1 0.3 GO:0045923 positive regulation of fatty acid metabolic process(GO:0045923)
0.1 0.3 GO:1902532 negative regulation of intracellular signal transduction(GO:1902532)
0.1 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.3 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.4 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.1 0.5 GO:0032370 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.1 0.1 GO:0045913 positive regulation of cellular carbohydrate metabolic process(GO:0010676) positive regulation of carbohydrate metabolic process(GO:0045913)
0.1 0.5 GO:0006264 mitochondrial DNA replication(GO:0006264) positive regulation of DNA-dependent DNA replication(GO:2000105)
0.1 1.6 GO:0030474 spindle pole body duplication(GO:0030474)
0.1 1.7 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.1 0.2 GO:0036293 response to decreased oxygen levels(GO:0036293) response to oxygen levels(GO:0070482)
0.1 1.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 1.2 GO:0055074 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.1 0.6 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.1 0.6 GO:0044746 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.1 0.3 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.1 0.3 GO:0015802 basic amino acid transport(GO:0015802)
0.1 0.3 GO:0045117 azole transport(GO:0045117)
0.1 1.2 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.6 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 1.4 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 0.4 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.1 0.9 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.4 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 0.4 GO:0036010 protein localization to endosome(GO:0036010)
0.1 0.8 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.7 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.3 GO:0072479 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 1.4 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.5 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 1.7 GO:0008361 regulation of cell size(GO:0008361)
0.1 1.2 GO:0001558 regulation of cell growth(GO:0001558)
0.1 0.3 GO:0042407 cristae formation(GO:0042407)
0.1 0.9 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 0.2 GO:0042148 strand invasion(GO:0042148)
0.1 0.1 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.1 0.2 GO:0061647 negative regulation of histone modification(GO:0031057) histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.1 0.2 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1 0.1 GO:0051098 regulation of binding(GO:0051098)
0.1 0.1 GO:0008272 sulfate transport(GO:0008272)
0.1 0.6 GO:0005977 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.1 0.8 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.1 1.4 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 0.6 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.1 0.1 GO:0019748 secondary metabolic process(GO:0019748)
0.1 0.4 GO:0016233 telomere capping(GO:0016233)
0.1 0.2 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.1 0.8 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.2 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.8 GO:0034629 cellular protein complex localization(GO:0034629)
0.1 0.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.3 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.1 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.4 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.0 0.8 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.2 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.2 GO:0006167 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.0 0.3 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.0 0.7 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.1 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.4 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.7 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.3 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.1 GO:0023056 positive regulation of signal transduction(GO:0009967) positive regulation of signaling(GO:0023056)
0.0 0.1 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.2 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0 0.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.2 GO:0046785 microtubule nucleation(GO:0007020) microtubule polymerization(GO:0046785)
0.0 0.1 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.0 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.0 GO:0090630 activation of GTPase activity(GO:0090630)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.5 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
3.1 37.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
2.7 10.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
2.5 7.6 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
2.3 13.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
2.0 15.8 GO:0042597 periplasmic space(GO:0042597)
1.9 5.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.9 9.4 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.5 34.0 GO:0070469 respiratory chain(GO:0070469)
1.2 3.7 GO:0045240 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
1.2 3.6 GO:0046930 pore complex(GO:0046930)
1.1 63.1 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
1.0 2.9 GO:0032176 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
1.0 4.8 GO:0032221 Rpd3S complex(GO:0032221)
0.8 11.0 GO:0005619 ascospore wall(GO:0005619)
0.8 4.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.8 3.0 GO:0033551 monopolin complex(GO:0033551)
0.7 2.0 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.6 5.8 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.6 3.3 GO:0034967 Set3 complex(GO:0034967)
0.6 26.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.6 3.3 GO:0032126 eisosome(GO:0032126)
0.5 3.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.5 8.0 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.5 6.4 GO:0098798 mitochondrial protein complex(GO:0098798)
0.5 3.3 GO:0034657 GID complex(GO:0034657)
0.5 1.8 GO:0001400 mating projection base(GO:0001400)
0.4 4.3 GO:0033698 Rpd3L complex(GO:0033698)
0.4 1.7 GO:0030666 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.4 2.0 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.4 2.8 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.4 2.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 56.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.4 9.2 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.3 1.0 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.3 1.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.3 4.5 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.3 1.9 GO:0031932 TORC2 complex(GO:0031932)
0.3 1.2 GO:0032116 SMC loading complex(GO:0032116)
0.3 0.9 GO:0005960 glycine cleavage complex(GO:0005960)
0.3 0.9 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.3 26.0 GO:0005740 mitochondrial envelope(GO:0005740)
0.2 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 0.5 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.2 3.3 GO:0000812 Swr1 complex(GO:0000812)
0.2 2.0 GO:0000795 synaptonemal complex(GO:0000795)
0.2 1.0 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.2 1.2 GO:0033263 CORVET complex(GO:0033263)
0.2 2.2 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.2 2.9 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.2 0.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 3.4 GO:0016592 mediator complex(GO:0016592)
0.2 88.3 GO:0005739 mitochondrion(GO:0005739)
0.1 0.7 GO:0031968 outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.1 0.3 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.1 0.6 GO:0019866 organelle inner membrane(GO:0019866)
0.1 0.9 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.3 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 0.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.2 GO:0070209 ASTRA complex(GO:0070209)
0.1 0.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.5 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 1.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.2 GO:0032301 MutSalpha complex(GO:0032301)
0.1 0.3 GO:0005771 multivesicular body(GO:0005771)
0.1 1.1 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.1 0.6 GO:0005769 early endosome(GO:0005769)
0.1 0.4 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.1 0.2 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.0 0.4 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.2 GO:0000835 cytoplasmic ubiquitin ligase complex(GO:0000153) ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.4 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.2 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 0.0 GO:0030897 HOPS complex(GO:0030897)
0.0 0.1 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.1 GO:0030907 MBF transcription complex(GO:0030907)
0.0 1.5 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.4 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.2 24.7 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
7.1 28.4 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
6.7 20.0 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
5.9 17.6 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
4.8 19.3 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
4.6 22.8 GO:0015295 solute:proton symporter activity(GO:0015295)
3.9 15.4 GO:0004396 hexokinase activity(GO:0004396)
3.7 11.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
3.5 10.6 GO:0016289 CoA hydrolase activity(GO:0016289)
3.4 16.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
3.2 12.9 GO:0005537 mannose binding(GO:0005537)
2.8 11.1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
2.3 11.6 GO:0008198 ferrous iron binding(GO:0008198)
2.2 9.0 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
2.2 8.8 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091) TFIIH-class transcription factor binding(GO:0001097)
2.1 16.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
2.1 22.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.9 5.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.9 11.5 GO:0000400 four-way junction DNA binding(GO:0000400)
1.9 5.7 GO:0005536 glucose binding(GO:0005536)
1.9 5.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
1.9 9.4 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.9 3.7 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.8 17.6 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
1.4 8.6 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.4 4.2 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.2 12.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
1.2 2.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
1.2 3.6 GO:0008308 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
1.0 15.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
1.0 15.9 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.9 3.8 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.9 2.8 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.9 8.2 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.9 12.3 GO:0015297 antiporter activity(GO:0015297)
0.8 6.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.8 2.5 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.8 6.5 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.8 4.0 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.7 5.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.7 2.9 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.7 6.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.7 2.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.7 2.1 GO:0016208 AMP binding(GO:0016208)
0.7 6.2 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.7 4.8 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.7 5.4 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.7 6.7 GO:0035064 methylated histone binding(GO:0035064)
0.7 2.6 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.6 1.9 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.6 1.9 GO:0016417 S-acyltransferase activity(GO:0016417)
0.6 10.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.6 6.4 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.6 2.3 GO:0019776 Atg8 ligase activity(GO:0019776)
0.6 3.4 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.6 1.7 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.6 3.4 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.6 2.2 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.6 0.6 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.5 2.1 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.5 6.8 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.5 1.0 GO:0015038 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.5 3.9 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.5 1.9 GO:0016531 copper chaperone activity(GO:0016531)
0.5 2.8 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.4 9.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.4 1.3 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.4 3.2 GO:0042802 identical protein binding(GO:0042802) protein homodimerization activity(GO:0042803)
0.4 1.6 GO:0016408 C-acyltransferase activity(GO:0016408)
0.4 6.4 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.4 3.0 GO:0034979 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.4 1.5 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.4 4.8 GO:0050661 NADP binding(GO:0050661)
0.4 3.3 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 2.1 GO:0042887 amide transmembrane transporter activity(GO:0042887)
0.3 14.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.3 1.0 GO:0070569 uridylyltransferase activity(GO:0070569)
0.3 1.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.3 1.0 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.3 1.8 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.3 7.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.3 0.9 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.3 1.5 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.3 1.8 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 13.0 GO:0043492 ATPase activity, coupled to movement of substances(GO:0043492)
0.3 1.3 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.3 1.1 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.3 1.3 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.2 4.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.2 3.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 0.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 7.0 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.2 5.3 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.2 2.0 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.2 1.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.2 0.6 GO:0004629 phospholipase C activity(GO:0004629)
0.2 1.5 GO:0005516 calmodulin binding(GO:0005516)
0.2 2.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.2 2.0 GO:0043495 protein anchor(GO:0043495)
0.2 4.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 0.5 GO:0032183 SUMO binding(GO:0032183)
0.2 1.4 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.2 0.8 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 0.5 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.2 0.5 GO:0000150 recombinase activity(GO:0000150)
0.2 1.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 14.5 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.2 0.5 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 2.7 GO:0022804 active transmembrane transporter activity(GO:0022804)
0.1 1.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 1.1 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1 2.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 0.9 GO:0005507 copper ion binding(GO:0005507)
0.1 0.4 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.1 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.1 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 8.6 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 1.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.5 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.2 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.1 1.5 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.4 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.8 GO:0000149 SNARE binding(GO:0000149)
0.1 2.0 GO:0003684 damaged DNA binding(GO:0003684)
0.1 1.9 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 2.6 GO:0032182 ubiquitin-like protein binding(GO:0032182) ubiquitin binding(GO:0043130)
0.1 0.4 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.1 0.7 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 1.1 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.5 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.7 GO:0051287 NAD binding(GO:0051287)
0.1 0.2 GO:0052744 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.1 1.2 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.3 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 1.7 GO:0046983 protein dimerization activity(GO:0046983)
0.1 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.1 GO:0045118 azole transporter activity(GO:0045118)
0.1 0.2 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0004672 protein kinase activity(GO:0004672)
0.0 0.1 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.0 0.1 GO:0017171 serine hydrolase activity(GO:0017171)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.3 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.0 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.7 5.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
1.3 11.3 PID FANCONI PATHWAY Fanconi anemia pathway
1.1 3.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5 1.0 PID NOTCH PATHWAY Notch signaling pathway
0.4 1.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.4 2.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 0.4 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.2 0.4 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.2 247.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 0.3 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 0.5 PID P73PATHWAY p73 transcription factor network
0.1 0.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 0.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.0 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 18.7 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
2.6 23.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.7 5.2 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
1.7 5.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 1.0 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.3 1.1 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.2 0.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 1.2 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.2 241.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.7 REACTOME INNATE IMMUNE SYSTEM Genes involved in Innate Immune System
0.1 0.6 REACTOME MEMBRANE TRAFFICKING Genes involved in Membrane Trafficking
0.1 0.3 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.1 0.5 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.1 0.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME MEIOSIS Genes involved in Meiosis
0.0 0.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME DNA REPAIR Genes involved in DNA Repair