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Results for ORC1

Z-value: 1.04

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Transcription factors associated with ORC1

Gene Symbol Gene ID Gene Info
ORC1
S000004530 Largest subunit of the origin recognition complex

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ORC1YML065W0.619.7e-04Click!

Activity profile of ORC1 motif

Sorted Z-values of ORC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YAR053W 9.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR244W 5.58 Putative protein of unknown function
YAR060C 5.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR311C 5.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR212C 4.66 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR001W 4.41
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YHR212W-A 4.14 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YER065C 3.86
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YBR200W-A 3.86 Putative protein of unknown function; identified by fungal homology and RT-PCR
YAL039C 3.72
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YMR107W 3.68
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YAL062W 3.57
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YNL013C 3.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
YOR345C 3.43 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YAR070C 3.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCL054W 3.31
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YAR069C 3.12 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR138C 3.11 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YKL217W 3.03
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YOR346W 2.99
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YNL180C 2.83
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YAR050W 2.81
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YCL069W 2.79
VBA3
Permease of basic amino acids in the vacuolar membrane
YFR032C-B 2.79 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGR225W 2.71
AMA1
Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis
YJR095W 2.69
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YNL179C 2.65 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YJR048W 2.62
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YIL057C 2.59 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YKR105C 2.51
VBA5
Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny
YBR296C 2.49
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YPL033C 2.49 Putative protein of unknown function; may be involved in DNA metabolism; expression is induced by Kar4p
YGR087C 2.43
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YEL030C-A 2.42 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDL210W 2.41
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YML042W 2.37
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YIL055C 2.37 Putative protein of unknown function
YEL030W 2.29
ECM10
Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations
YDL244W 2.29
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YOL051W 2.28
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YLR307W 2.26
CDA1
Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YBL043W 2.25
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR311C 2.25
GLC8
Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2
YMR206W 2.23 Putative protein of unknown function; YMR206W is not an essential gene
YKR097W 2.21
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YGR236C 2.13
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR307C-A 2.13 Putative protein of unknown function
YDL138W 2.13
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YDR259C 2.11
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YGR258C 2.09
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YDL139C 2.04
SCM3
Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p
YFL011W 2.04
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YBR292C 1.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YDL223C 1.98
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YGL163C 1.98
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YLR356W 1.97 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YKL031W 1.97 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YLR296W 1.93 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL007W 1.92 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YOR214C 1.92 Putative protein of unknown function; YOR214C is not an essential gene
YAR047C 1.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER033C 1.89
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YKL109W 1.83
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YFL051C 1.82 Putative protein of unknown function; YFL051C is not an essential gene
YAL054C 1.80
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YLR327C 1.80
TMA10
Protein of unknown function that associates with ribosomes
YJL037W 1.78
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YOL060C 1.77
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YNL093W 1.73
YPT53
GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YGR144W 1.72
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YDR342C 1.67
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YHR139C 1.67
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YGL096W 1.66
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YOR178C 1.62
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YJR078W 1.62
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YHR217C 1.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YKL028W 1.60
TFA1
TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YCL038C 1.58
ATG22
Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
YNR073C 1.58 Putative mannitol dehydrogenase
YGR059W 1.57
SPR3
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI
YNL117W 1.55
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YMR182C 1.54
RGM1
Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth
YHR095W 1.54 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL066C 1.53
RNR3
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YEL012W 1.53
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YDL204W 1.52
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YBR250W 1.52
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YCR091W 1.51
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YJR128W 1.51 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YER121W 1.47 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YGR043C 1.47
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YNL014W 1.46
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YFL058W 1.45
THI5
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YMR081C 1.43
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YPR150W 1.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YPR002W 1.40
PDH1
Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YAL001C 1.37
TFC3
Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YER132C 1.36
PMD1
Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions
YKR102W 1.36
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YNL332W 1.34
THI12
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YOR072W 1.34 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YJL043W 1.34 Putative protein of unknown function; YJL043W is a non-essential gene
YCL073C 1.33 Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W
YAL067C 1.30
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YPR007C 1.29
REC8
Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
YGR039W 1.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YDL245C 1.28
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YIL045W 1.28
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YOR348C 1.28
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YDR310C 1.28
SUM1
Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint
YLR377C 1.27
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YPL026C 1.27
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YFR012W 1.27 Putative protein of unknown function
YDR504C 1.27
SPG3
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YKR106W 1.27 Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YCL073C
YHR071W 1.26
PCL5
Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YPL116W 1.26
HOS3
Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
YDL085W 1.25
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YMR017W 1.24
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YPL089C 1.24
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YKL029C 1.24
MAE1
Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
YLR278C 1.22 Zinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene
YDL130W-A 1.22
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YOR066W 1.22
MSA1
Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YDR119W-A 1.20 Putative protein of unknown function
YHR096C 1.20
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YMR180C 1.19
CTL1
RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm
YGL045W 1.19
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YJR150C 1.19
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YKL102C 1.18 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YMR191W 1.17
SPG5
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YEL070W 1.15
DSF1
Deletion suppressor of mpt5 mutation
YGR243W 1.12
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL100C 1.12 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YDR018C 1.12 Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype
YPR192W 1.10
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YMR068W 1.10
AVO2
Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YNL144C 1.09 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YDR199W 1.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
YGR022C 1.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YOR100C 1.09
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YMR256C 1.08
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YCR086W 1.08
CSM1
Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
YLR279W 1.07 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR097C 1.07 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YGR070W 1.07
ROM1
GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YFL061W 1.07
DDI2
Protein whose expression is induced by DNA damage
YJL133C-A 1.07 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR308W 1.05
CDA2
Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YAL063C 1.05
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YBR072W 1.05
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YJL089W 1.05
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YDR406W 1.05
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YPR193C 1.04
HPA2
Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
YGL117W 1.04 Putative protein of unknown function
YDR464W 1.04
SPP41
Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
YGR230W 1.04
BNS1
Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis
YEL009C 1.04
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YDL170W 1.04
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YDL214C 1.03
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YPR030W 1.03
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YOR393W 1.02
ERR1
Protein of unknown function, has similarity to enolases
YEL033W 1.02
MTC7
Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YFR010W-A 1.02 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YFR011C; identified by expression profiling and mass spectrometry
YCL048W 1.02
SPS22
Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YDR171W 1.01
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YAR068W 1.01 Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YAL018C 1.01 Putative protein of unknown function
YNL318C 1.01
HXT14
Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL012W 1.00
SPO1
Meiosis-specific protein with similarity to phospholipase B, required for meiotic spindle pole body duplication and separation; required for spore formation
YDR092W 1.00
UBC13
Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YOR344C 1.00
TYE7
Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
YOR394W 0.99
PAU21
Hypothetical protein
YOR388C 0.99
FDH1
NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
YJR159W 0.99
SOR1
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YCL012C 0.99 Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene
YGR023W 0.99
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YFR023W 0.98
PES4
Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
YBR040W 0.98
FIG1
Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
YPR026W 0.98
ATH1
Acid trehalase required for utilization of extracellular trehalose
YPR127W 0.98 Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YIL160C 0.98
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YCL001W-B 0.98 Putative protein of unknown function; identified by homology
YKR073C 0.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR431C 0.97
ATG23
Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway; cycles between the pre-autophagosome (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p
YBR230C 0.97
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YIR014W 0.97 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene
YPR078C 0.97 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YIL136W 0.96
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YDL172C 0.96 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YMR251W 0.95
GTO3
Omega class glutathione transferase; putative cytosolic localization
YNL018C 0.95 Putative protein of unknown function
YBL048W 0.94 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YGL230C 0.94 Putative protein of unknown function; non-essential gene
YOR355W 0.94
GDS1
Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHL041W 0.93 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YBR295W 0.93
PCA1
Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function
YLL029W 0.93
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YJR154W 0.93 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL038W 0.92
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor

Network of associatons between targets according to the STRING database.

First level regulatory network of ORC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.3 3.8 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.2 7.0 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.1 4.4 GO:0006848 pyruvate transport(GO:0006848)
1.0 2.9 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.9 2.8 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.8 2.5 GO:0009593 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.8 3.2 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.7 2.1 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.7 2.0 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.7 0.7 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.6 1.2 GO:0035948 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.6 1.8 GO:0005993 trehalose catabolic process(GO:0005993)
0.6 5.1 GO:0006097 glyoxylate cycle(GO:0006097)
0.5 9.2 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.5 1.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.5 2.1 GO:0015809 arginine transport(GO:0015809)
0.5 1.5 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.5 1.0 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.5 2.0 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.5 2.4 GO:0006026 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.4 1.7 GO:0046323 glucose import(GO:0046323)
0.4 3.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 7.4 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.4 2.1 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.4 1.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.4 2.0 GO:0016242 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.4 1.2 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.4 0.4 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.4 1.2 GO:0070583 spore membrane bending pathway(GO:0070583)
0.4 1.6 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.4 1.2 GO:0006171 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.4 1.9 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.4 1.2 GO:0006108 malate metabolic process(GO:0006108)
0.4 1.9 GO:0051099 positive regulation of binding(GO:0051099)
0.4 1.5 GO:0015847 putrescine transport(GO:0015847)
0.4 0.8 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.4 2.3 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.4 3.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.4 3.3 GO:0031167 rRNA methylation(GO:0031167)
0.4 2.6 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.4 1.1 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.4 3.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.4 1.1 GO:0015888 thiamine transport(GO:0015888)
0.4 0.4 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.3 1.0 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.3 2.4 GO:0015802 basic amino acid transport(GO:0015802)
0.3 0.3 GO:0043419 urea catabolic process(GO:0043419)
0.3 3.0 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.3 1.3 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993)
0.3 2.3 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.3 1.9 GO:0001041 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.3 1.3 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.3 1.6 GO:0043954 cellular component maintenance(GO:0043954)
0.3 0.3 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.3 1.2 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.3 0.6 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.3 2.3 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
0.3 0.9 GO:0015691 cadmium ion transport(GO:0015691)
0.3 4.2 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.3 1.6 GO:0032120 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.3 1.6 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.3 1.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.3 1.6 GO:0051322 anaphase(GO:0051322)
0.3 1.9 GO:0043457 regulation of cellular respiration(GO:0043457)
0.3 1.6 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.3 0.3 GO:0018209 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.3 0.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.3 0.8 GO:0044209 AMP salvage(GO:0044209)
0.3 1.0 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.3 2.3 GO:0015688 iron chelate transport(GO:0015688)
0.3 1.3 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.3 2.1 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.3 1.5 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.2 0.7 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 1.0 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.2 0.9 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.2 1.6 GO:0061013 regulation of mRNA catabolic process(GO:0061013)
0.2 0.7 GO:0050810 regulation of steroid metabolic process(GO:0019218) regulation of ergosterol biosynthetic process(GO:0032443) regulation of steroid biosynthetic process(GO:0050810)
0.2 2.4 GO:0015893 drug transport(GO:0015893)
0.2 1.1 GO:0015793 glycerol transport(GO:0015793)
0.2 0.9 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.2 1.3 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.2 1.0 GO:0045033 peroxisome inheritance(GO:0045033)
0.2 1.0 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.2 0.8 GO:0071456 cellular response to hypoxia(GO:0071456)
0.2 0.6 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.2 1.4 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.2 0.6 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 0.6 GO:0042843 D-xylose catabolic process(GO:0042843)
0.2 2.9 GO:0042026 protein refolding(GO:0042026)
0.2 0.6 GO:0043007 maintenance of rDNA(GO:0043007)
0.2 0.8 GO:0015804 neutral amino acid transport(GO:0015804)
0.2 2.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.2 0.6 GO:0007019 microtubule depolymerization(GO:0007019)
0.2 0.6 GO:0045128 negative regulation of reciprocal meiotic recombination(GO:0045128)
0.2 6.3 GO:0010927 cellular component assembly involved in morphogenesis(GO:0010927)
0.2 0.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.2 1.4 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.2 0.9 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.2 0.5 GO:0006452 translational frameshifting(GO:0006452)
0.2 0.5 GO:0001927 exocyst assembly(GO:0001927)
0.2 1.1 GO:0051260 protein homooligomerization(GO:0051260)
0.2 0.7 GO:0000755 cytogamy(GO:0000755)
0.2 0.7 GO:0071331 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.2 0.5 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.2 1.2 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.2 0.7 GO:0043649 dicarboxylic acid catabolic process(GO:0043649)
0.2 0.3 GO:0000078 obsolete cytokinesis after mitosis checkpoint(GO:0000078)
0.2 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 1.0 GO:0006449 regulation of translational termination(GO:0006449)
0.2 0.6 GO:0015976 carbon utilization(GO:0015976)
0.2 0.5 GO:1902749 regulation of G2/M transition of mitotic cell cycle(GO:0010389) negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) mitotic G2/M transition checkpoint(GO:0044818) regulation of cell cycle G2/M phase transition(GO:1902749) negative regulation of cell cycle G2/M phase transition(GO:1902750)
0.2 0.6 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.2 2.5 GO:0006754 ATP biosynthetic process(GO:0006754)
0.2 1.6 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.2 0.5 GO:0006545 glycine biosynthetic process(GO:0006545)
0.2 1.1 GO:0006641 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.2 0.3 GO:0006102 isocitrate metabolic process(GO:0006102)
0.2 0.8 GO:0031032 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.2 0.5 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 0.3 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.1 0.7 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.1 1.3 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.4 GO:1903339 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.1 2.5 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 3.8 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.1 0.3 GO:0008105 asymmetric protein localization(GO:0008105)
0.1 1.0 GO:0045931 positive regulation of mitotic cell cycle(GO:0045931)
0.1 0.3 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.1 0.1 GO:0001323 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324) age-dependent general metabolic decline(GO:0007571)
0.1 0.6 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 0.4 GO:0006265 DNA topological change(GO:0006265)
0.1 0.3 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.1 0.4 GO:0019388 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.6 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 0.6 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.3 GO:0071467 cellular response to pH(GO:0071467)
0.1 0.2 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.1 0.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.6 GO:0051180 vitamin transport(GO:0051180)
0.1 0.2 GO:0097271 protein localization to bud neck(GO:0097271)
0.1 0.5 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.1 2.1 GO:0098656 anion transmembrane transport(GO:0098656)
0.1 0.8 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 0.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 0.3 GO:0006003 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.3 GO:0042493 response to drug(GO:0042493)
0.1 0.7 GO:0031578 mitotic spindle orientation checkpoint(GO:0031578)
0.1 1.0 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.1 0.2 GO:0043200 response to amino acid(GO:0043200)
0.1 0.5 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 1.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.6 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.5 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 0.4 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.3 GO:0036257 multivesicular body organization(GO:0036257)
0.1 0.2 GO:0000729 DNA double-strand break processing(GO:0000729)
0.1 0.4 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 1.6 GO:0007020 microtubule nucleation(GO:0007020)
0.1 0.5 GO:0006476 protein deacetylation(GO:0006476) protein deacylation(GO:0035601) macromolecule deacylation(GO:0098732)
0.1 0.4 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.1 0.1 GO:0051098 regulation of binding(GO:0051098)
0.1 0.3 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.1 0.1 GO:0044109 cellular alcohol catabolic process(GO:0044109)
0.1 2.8 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 0.4 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.5 GO:0006020 inositol metabolic process(GO:0006020)
0.1 1.5 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.2 GO:0045117 azole transport(GO:0045117)
0.1 0.2 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.4 GO:0006591 ornithine metabolic process(GO:0006591)
0.1 0.2 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 0.1 GO:0019566 arabinose metabolic process(GO:0019566) arabinose catabolic process(GO:0019568)
0.1 0.2 GO:0090399 replicative senescence(GO:0090399)
0.1 0.8 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.1 0.3 GO:0046688 response to copper ion(GO:0046688)
0.1 0.5 GO:0000320 re-entry into mitotic cell cycle(GO:0000320) re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.3 GO:0032147 activation of protein kinase activity(GO:0032147)
0.1 0.4 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.1 0.3 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.1 0.8 GO:0030261 chromosome condensation(GO:0030261)
0.1 0.7 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.3 GO:0001934 positive regulation of protein phosphorylation(GO:0001934)
0.1 0.5 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.1 1.0 GO:0008361 regulation of cell size(GO:0008361)
0.1 0.4 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 1.3 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.2 GO:0006546 glycine catabolic process(GO:0006546)
0.1 0.4 GO:0000023 maltose metabolic process(GO:0000023)
0.1 1.2 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.6 GO:0007129 synapsis(GO:0007129)
0.1 0.9 GO:0042775 respiratory electron transport chain(GO:0022904) ATP synthesis coupled electron transport(GO:0042773) mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.1 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.1 0.2 GO:0033523 histone H2B ubiquitination(GO:0033523) histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.1 0.6 GO:0015914 phospholipid transport(GO:0015914)
0.1 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.1 GO:0007032 endosome organization(GO:0007032)
0.1 0.3 GO:0000266 mitochondrial fission(GO:0000266)
0.1 0.1 GO:0006344 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.1 0.1 GO:0001112 DNA-templated transcriptional open complex formation(GO:0001112) protein-DNA complex remodeling(GO:0001120) macromolecular complex remodeling(GO:0034367)
0.1 0.7 GO:0031929 TOR signaling(GO:0031929)
0.1 0.5 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.5 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.1 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 0.2 GO:0000076 DNA replication checkpoint(GO:0000076)
0.1 3.5 GO:0048646 anatomical structure formation involved in morphogenesis(GO:0048646)
0.1 0.7 GO:0043486 histone exchange(GO:0043486)
0.1 1.8 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.6 GO:0000902 cell morphogenesis(GO:0000902)
0.1 0.5 GO:0006813 potassium ion transport(GO:0006813)
0.0 0.2 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.1 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.0 0.4 GO:0001101 response to acid chemical(GO:0001101)
0.0 0.1 GO:0000087 mitotic M phase(GO:0000087) M phase(GO:0000279)
0.0 0.1 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.0 GO:0051403 stress-activated protein kinase signaling cascade(GO:0031098) regulation of stress-activated MAPK cascade(GO:0032872) stress-activated MAPK cascade(GO:0051403) regulation of stress-activated protein kinase signaling cascade(GO:0070302)
0.0 0.1 GO:0070054 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.0 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0 0.4 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.3 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.5 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.1 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.0 0.1 GO:0008272 sulfate transport(GO:0008272)
0.0 0.1 GO:0051346 negative regulation of hydrolase activity(GO:0051346)
0.0 0.2 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.0 0.2 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.0 GO:1902533 positive regulation of intracellular signal transduction(GO:1902533)
0.0 0.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.0 GO:0042148 strand invasion(GO:0042148)
0.0 0.4 GO:0009651 response to salt stress(GO:0009651)
0.0 0.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.1 GO:1903313 positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.0 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.0 0.0 GO:0009967 positive regulation of signal transduction(GO:0009967) positive regulation of signaling(GO:0023056)
0.0 0.2 GO:0055088 lipid homeostasis(GO:0055088)
0.0 0.3 GO:0051156 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.3 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.0 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.3 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.0 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.0 0.0 GO:0043270 positive regulation of ion transport(GO:0043270)
0.0 0.1 GO:0007030 Golgi organization(GO:0007030)
0.0 0.0 GO:0034982 mitochondrial protein processing(GO:0034982)
0.0 0.1 GO:1901976 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.2 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.1 GO:0019320 hexose catabolic process(GO:0019320)
0.0 0.1 GO:0033674 positive regulation of kinase activity(GO:0033674)
0.0 0.0 GO:0042710 biofilm formation(GO:0042710)
0.0 0.3 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.0 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.0 0.2 GO:0000077 DNA damage checkpoint(GO:0000077)
0.0 0.0 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.0 0.1 GO:0045833 negative regulation of lipid metabolic process(GO:0045833)
0.0 0.0 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.1 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.3 GO:0031503 protein complex localization(GO:0031503)
0.0 0.9 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.1 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.1 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.0 0.4 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.0 GO:2000218 regulation of invasive growth in response to glucose limitation(GO:2000217) negative regulation of invasive growth in response to glucose limitation(GO:2000218)
0.0 0.0 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.0 0.1 GO:0022610 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.0 0.1 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094)
0.0 0.0 GO:0031055 chromatin remodeling at centromere(GO:0031055)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.9 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.5 1.6 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.5 1.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 1.3 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.4 0.9 GO:0001400 mating projection base(GO:0001400)
0.4 4.2 GO:0031160 spore wall(GO:0031160)
0.3 1.4 GO:0033551 monopolin complex(GO:0033551)
0.3 1.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 2.2 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.3 1.9 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.3 7.0 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.3 2.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 0.5 GO:0051233 spindle midzone(GO:0051233)
0.3 1.6 GO:0031932 TORC2 complex(GO:0031932)
0.2 0.7 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 0.7 GO:0032807 DNA ligase IV complex(GO:0032807)
0.2 3.3 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.2 0.7 GO:0030874 nucleolar chromatin(GO:0030874)
0.2 1.5 GO:0034657 GID complex(GO:0034657)
0.2 0.9 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.2 0.8 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.2 3.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 1.1 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.2 0.7 GO:0008623 CHRAC(GO:0008623)
0.2 1.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 4.4 GO:0070469 respiratory chain(GO:0070469)
0.2 0.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 0.5 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.7 GO:0005771 multivesicular body(GO:0005771)
0.1 0.9 GO:0000133 polarisome(GO:0000133)
0.1 0.6 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 0.4 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.4 GO:0042597 periplasmic space(GO:0042597)
0.1 0.7 GO:0044233 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.3 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.1 0.4 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.8 GO:0005871 kinesin complex(GO:0005871)
0.1 0.3 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 0.3 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013)
0.1 1.4 GO:0005769 early endosome(GO:0005769)
0.1 0.6 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 0.5 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.1 4.9 GO:0044438 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.1 0.4 GO:0030870 Mre11 complex(GO:0030870)
0.1 3.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.5 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.1 0.5 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.1 0.7 GO:0034967 Set3 complex(GO:0034967)
0.1 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.3 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.1 0.3 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.1 0.2 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 3.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.5 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 4.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.2 GO:0031010 ISWI-type complex(GO:0031010)
0.1 0.8 GO:0005875 microtubule associated complex(GO:0005875)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.5 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 2.2 GO:0005770 late endosome(GO:0005770)
0.1 0.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.4 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.1 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.1 0.5 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 3.1 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.1 0.2 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.1 0.2 GO:0070390 transcription export complex 2(GO:0070390)
0.1 0.7 GO:0000124 SAGA complex(GO:0000124)
0.1 0.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.8 GO:0033698 Rpd3L complex(GO:0033698)
0.0 4.3 GO:0000790 nuclear chromatin(GO:0000790)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.6 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.6 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:0097196 Shu complex(GO:0097196)
0.0 0.2 GO:0045334 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.1 GO:0070274 RES complex(GO:0070274)
0.0 1.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.1 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 2.9 GO:0005937 mating projection(GO:0005937) cell projection(GO:0042995)
0.0 0.2 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.1 GO:0032176 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 3.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0005824 outer plaque of spindle pole body(GO:0005824)
0.0 0.3 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.2 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.0 0.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.5 GO:0097525 spliceosomal snRNP complex(GO:0097525)
0.0 0.1 GO:0070772 PAS complex(GO:0070772)
0.0 0.0 GO:0051286 cell tip(GO:0051286)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.5 6.1 GO:0005537 mannose binding(GO:0005537)
1.2 6.0 GO:0015295 solute:proton symporter activity(GO:0015295)
0.9 2.8 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.9 3.7 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.8 3.4 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.8 2.5 GO:0005536 glucose binding(GO:0005536)
0.8 3.2 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.8 3.0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.6 1.8 GO:0016208 AMP binding(GO:0016208)
0.6 3.0 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.6 1.8 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.6 2.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.6 1.7 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 2.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.5 3.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.5 1.4 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.4 2.6 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.4 1.2 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.4 1.6 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.4 1.9 GO:0008198 ferrous iron binding(GO:0008198)
0.3 1.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.3 3.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.3 1.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.3 1.0 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.3 1.3 GO:0016725 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 2.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.3 1.9 GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.3 0.9 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.3 0.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 1.4 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.3 0.8 GO:0032183 SUMO binding(GO:0032183)
0.3 1.4 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.3 1.1 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.3 0.8 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.3 5.2 GO:0019213 deacetylase activity(GO:0019213)
0.3 0.3 GO:0019902 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.3 2.7 GO:0015145 monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.3 1.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 1.0 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.3 0.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.0 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.2 1.0 GO:0045118 azole transporter activity(GO:0045118)
0.2 4.1 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.2 0.7 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.2 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 1.8 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 1.3 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.2 2.4 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.2 0.4 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.2 2.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.2 0.8 GO:0004396 hexokinase activity(GO:0004396)
0.2 0.4 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.2 0.6 GO:0003680 AT DNA binding(GO:0003680)
0.2 0.8 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 5.2 GO:0003684 damaged DNA binding(GO:0003684)
0.2 3.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 0.7 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.2 2.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 0.7 GO:0000182 rDNA binding(GO:0000182)
0.2 1.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 0.5 GO:0016898 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.2 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 0.6 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.2 0.6 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.1 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 1.2 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.7 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 1.1 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.1 3.0 GO:0031491 nucleosome binding(GO:0031491)
0.1 5.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 0.1 GO:0051119 sugar transmembrane transporter activity(GO:0051119)
0.1 1.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 1.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 0.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.4 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 2.8 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.1 0.4 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 1.4 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.8 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 0.6 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.4 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 0.2 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.1 0.8 GO:0015293 symporter activity(GO:0015293)
0.1 0.3 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.5 GO:0017022 myosin binding(GO:0017022)
0.1 1.6 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 0.3 GO:0016289 CoA hydrolase activity(GO:0016289)
0.1 0.5 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.2 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.1 0.4 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.1 1.3 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.1 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.1 0.7 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.1 0.4 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 0.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 0.3 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.1 0.2 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.1 0.1 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 0.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 1.9 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.1 0.3 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 1.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 0.6 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.5 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.2 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.2 GO:0048038 quinone binding(GO:0048038)
0.1 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 0.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.1 GO:0001007 transcription factor activity, RNA polymerase III transcription factor binding(GO:0001007)
0.1 0.6 GO:0016722 oxidoreductase activity, oxidizing metal ions(GO:0016722)
0.1 6.0 GO:0004672 protein kinase activity(GO:0004672)
0.1 1.5 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.2 GO:0016642 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.1 0.3 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.1 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.2 GO:0048256 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.1 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.0 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128)
0.0 0.7 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.9 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.2 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.1 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.1 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.0 0.1 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.0 2.3 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.0 0.6 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.3 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.2 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 1.0 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.5 GO:0043022 ribosome binding(GO:0043022)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0031072 heat shock protein binding(GO:0031072)
0.0 1.7 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.0 GO:0072341 modified amino acid binding(GO:0072341)
0.0 0.0 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.5 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.0 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.2 GO:0034061 DNA polymerase activity(GO:0034061)
0.0 0.1 GO:0017069 snRNA binding(GO:0017069)
0.0 0.1 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.2 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.0 GO:0008171 O-methyltransferase activity(GO:0008171)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 0.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 0.9 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 0.4 PID ATM PATHWAY ATM pathway
0.1 0.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 0.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 106.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.1 PID FOXO PATHWAY FoxO family signaling
0.0 0.2 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.0 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.8 2.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 0.8 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 2.8 REACTOME DNA REPAIR Genes involved in DNA Repair
0.2 1.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 0.2 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.1 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 105.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.0 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.1 REACTOME RNA POL II TRANSCRIPTION Genes involved in RNA Polymerase II Transcription
0.0 0.0 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 0.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.1 REACTOME MEIOSIS Genes involved in Meiosis