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Results for PDR8

Z-value: 0.77

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Transcription factors associated with PDR8

Gene Symbol Gene ID Gene Info
PDR8
S000004256 Transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PDR8YLR266C0.862.3e-08Click!

Activity profile of PDR8 motif

Sorted Z-values of PDR8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YIL057C 9.69 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YML042W 8.13
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YOR100C 7.52
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YOR343C 6.53 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YJL045W 6.15 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YOR348C 5.87
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YJR095W 5.27
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YMR107W 4.92
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YAL062W 4.70
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YLR377C 4.25
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YML081C-A 4.24
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YPL222C-A 4.24 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR536W 4.04
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YKR097W 3.96
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YCR007C 3.93 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YFL051C 3.85 Putative protein of unknown function; YFL051C is not an essential gene
YKL109W 3.41
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YHR139C 3.39
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YJL116C 3.39
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YDR530C 3.33
APA2
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YAL039C 3.25
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YLR307C-A 3.09 Putative protein of unknown function
YAR053W 3.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL017C 3.03
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YLR122C 2.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YGL258W-A 2.99 Putative protein of unknown function
YJR146W 2.94 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YEL008W 2.93 Hypothetical protein predicted to be involved in metabolism
YER014C-A 2.92
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YEL009C 2.79
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YLR346C 2.76 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YER067C-A 2.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
YJR048W 2.71
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YOR139C 2.67 Hypothetical protein
YDR343C 2.66
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YLR332W 2.66
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YHR001W-A 2.58
QCR10
Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YLR331C 2.57
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YPL181W 2.56
CTI6
Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YBL064C 2.55
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YOR140W 2.54
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YLR123C 2.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YPL186C 2.52
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YPL135W 2.51
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YGR023W 2.49
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YGR022C 2.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YDR406W 2.42
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YDR036C 2.39
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YEL028W 2.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL194W 2.35
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YPR013C 2.33 Putative zinc finger protein; YPR013C is not an essential gene
YML089C 2.30 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YHR096C 2.29
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YCR091W 2.28
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YHR048W 2.27
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YMR017W 2.25
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YAR050W 2.25
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YPL182C 2.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
YAR060C 2.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR296W 2.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL185W 2.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YOR065W 2.18
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YJL166W 2.17
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YDL214C 2.15
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YLR366W 2.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YFR053C 2.12
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YEL070W 2.11
DSF1
Deletion suppressor of mpt5 mutation
YOL157C 2.09 Putative protein of unknown function
YFL054C 2.08 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YDL215C 2.08
GDH2
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YNL305C 2.06 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YLR295C 2.06
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YCL001W-B 2.05 Putative protein of unknown function; identified by homology
YGL096W 1.99
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YOL128C 1.96
YGK3
Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YGR110W 1.94 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YFL052W 1.94 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YPL223C 1.94
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YGR236C 1.92
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL255W 1.92
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YLR304C 1.90
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YDR010C 1.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR045C 1.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR197C 1.87
SNG1
Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance
YOR381W 1.87
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YHR092C 1.87
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YER119C 1.84
AVT6
Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YKL221W 1.81
MCH2
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YBR072W 1.78
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YAR047C 1.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL054C 1.77
MCH1
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YJL220W 1.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2
YLL053C 1.73 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YJL127C-B 1.71 Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
YLR124W 1.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL177W 1.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YOR393W 1.66
ERR1
Protein of unknown function, has similarity to enolases
YDL244W 1.65
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YIL120W 1.64
QDR1
Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban
YPR061C 1.64
JID1
Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YOR049C 1.63
RSB1
Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YPL024W 1.63
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YPR192W 1.63
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YOR138C 1.62
RUP1
Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain
YNL055C 1.59
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YDR119W-A 1.59 Putative protein of unknown function
YEL065W 1.59
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YLR125W 1.56 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YGR087C 1.55
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YMR081C 1.55
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YFL030W 1.53
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YLL052C 1.52
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YDL210W 1.52
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YOL156W 1.51
HXT11
Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance
YJL221C 1.51
FSP2
Protein of unknown function, expression is induced during nitrogen limitation
YNL277W-A 1.50 Putative protein of unknown function
YGL187C 1.47
COX4
Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import; phosphorylated
YMR181C 1.44 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YPL201C 1.44
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YLR365W 1.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YDR171W 1.42
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YCR005C 1.42
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YOL082W 1.42
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YLR174W 1.41
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YDR043C 1.40
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YLL029W 1.39
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YIL160C 1.38
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YOL100W 1.37
PKH2
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YFR052C-A 1.37 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL089W 1.36
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YJL219W 1.35
HXT9
Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p
YDL246C 1.34
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YML090W 1.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YJL130C 1.34
URA2
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YNL194C 1.32 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YPL250C 1.32
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YKR009C 1.31
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YIR027C 1.31
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YOL081W 1.30
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YBR269C 1.29
FMP21
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR196W 1.29 Putative maltose activator
YDR001C 1.29
NTH1
Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
YPL092W 1.28
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YFL053W 1.27
DAK2
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YKL178C 1.25
STE3
Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YOR072W 1.24 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YNL180C 1.24
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YDR342C 1.24
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YJR159W 1.23
SOR1
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YML083C 1.22 Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
YDR277C 1.22
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YHL024W 1.21
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YPL026C 1.20
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YJR147W 1.20
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YLR259C 1.19
HSP60
Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YHR125W 1.19 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL026C 1.18
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YNL179C 1.17 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YOL154W 1.17
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YHR160C 1.17
PEX18
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
YOL084W 1.16
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YDR031W 1.16
MIC14
Mitochondrial intermembrane space cysteine motif protein of 14 kDa
YDR030C 1.16
RAD28
Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
YBL030C 1.15
PET9
Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
YAL063C 1.15
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YHR008C 1.14
SOD2
Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YDR231C 1.13
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YKL217W 1.13
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YDR377W 1.13
ATP17
Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDR287W 1.12
INM2
Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
YLL055W 1.11
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YDR533C 1.11
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YNL014W 1.11
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YPR113W 1.10
PIS1
Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
YPR010C-A 1.09 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YLL056C 1.09 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YGR239C 1.09
PEX21
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p
YOR371C 1.08
GPB1
Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p
YNL190W 1.07 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YGL072C 1.07 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YBL015W 1.04
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YOR071C 1.04
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YNR002C 1.03
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YFL024C 1.03
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YMR040W 1.03
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YML081W 1.03 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene
YOR391C 1.02
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YGR088W 1.01
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YBR280C 1.01
SAF1
F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
YDR455C 1.01 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
YOL051W 1.00
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YJL037W 0.99
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YBR297W 0.99
MAL33
MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YPR150W 0.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YOR072W-A 0.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YDR456W 0.98
NHX1
Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock
YDR014W-A 0.98
HED1
Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YFR026C 0.98 Putative protein of unknown function
YER158C 0.98 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YPL200W 0.98
CSM4
Protein required for accurate chromosome segregation during meiosis

Network of associatons between targets according to the STRING database.

First level regulatory network of PDR8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 8.9 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
1.6 6.3 GO:0015804 neutral amino acid transport(GO:0015804)
1.5 4.5 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.4 4.1 GO:0015755 fructose transport(GO:0015755)
1.3 3.9 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.3 3.9 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.1 3.3 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.0 10.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.9 3.6 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.7 3.0 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.7 2.2 GO:0005993 trehalose catabolic process(GO:0005993)
0.7 10.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.7 2.0 GO:0035948 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.6 1.9 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.6 2.5 GO:0070054 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.6 2.3 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.6 2.8 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.6 2.8 GO:0051099 positive regulation of binding(GO:0051099)
0.5 3.3 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.5 2.7 GO:0015793 glycerol transport(GO:0015793)
0.5 3.2 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.5 1.6 GO:0006545 glycine biosynthetic process(GO:0006545)
0.5 2.0 GO:0015847 putrescine transport(GO:0015847)
0.5 1.5 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.5 2.0 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.5 7.7 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.5 6.2 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.5 2.8 GO:0006097 glyoxylate cycle(GO:0006097)
0.5 1.4 GO:0015888 thiamine transport(GO:0015888)
0.4 3.9 GO:0045332 phospholipid translocation(GO:0045332)
0.4 1.7 GO:0015886 heme transport(GO:0015886)
0.4 1.7 GO:0006848 pyruvate transport(GO:0006848)
0.4 3.7 GO:0046686 response to cadmium ion(GO:0046686)
0.4 1.6 GO:0044070 regulation of anion transport(GO:0044070)
0.4 2.8 GO:0000023 maltose metabolic process(GO:0000023)
0.4 3.5 GO:0006829 zinc II ion transport(GO:0006829)
0.4 1.5 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.4 0.7 GO:0006754 ATP biosynthetic process(GO:0006754)
0.4 0.4 GO:0006740 NADPH regeneration(GO:0006740)
0.3 5.2 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.3 0.7 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.3 2.7 GO:0015891 siderophore transport(GO:0015891)
0.3 2.0 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.3 1.3 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.3 0.3 GO:1902222 L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.3 0.9 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.3 1.5 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.3 2.3 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.3 2.5 GO:0009746 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.3 1.4 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.3 0.3 GO:0034440 fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.3 1.1 GO:0072369 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.3 0.8 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.3 1.5 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.3 4.1 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.3 1.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 1.5 GO:0006020 inositol metabolic process(GO:0006020)
0.2 0.7 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.2 0.7 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.2 3.0 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.2 1.6 GO:0050821 protein stabilization(GO:0050821)
0.2 0.2 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.2 5.5 GO:0006094 gluconeogenesis(GO:0006094)
0.2 0.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.2 0.9 GO:0043200 response to amino acid(GO:0043200)
0.2 0.4 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 1.2 GO:0006279 premeiotic DNA replication(GO:0006279)
0.2 0.8 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.2 3.8 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.2 1.0 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.2 0.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 1.3 GO:0006083 acetate metabolic process(GO:0006083)
0.2 2.3 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.2 1.4 GO:0015893 drug transport(GO:0015893)
0.2 0.3 GO:0043335 protein unfolding(GO:0043335)
0.2 0.3 GO:0031647 regulation of protein stability(GO:0031647)
0.2 1.3 GO:0072348 sulfur compound transport(GO:0072348)
0.2 0.9 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.2 0.5 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.1 0.3 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.1 0.6 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.1 1.2 GO:0018345 protein palmitoylation(GO:0018345)
0.1 2.4 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.1 0.7 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 0.3 GO:0043270 positive regulation of ion transport(GO:0043270)
0.1 3.2 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 1.3 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.1 0.4 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.5 GO:0009300 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.1 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.4 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 0.5 GO:0070988 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.1 2.4 GO:0016579 protein deubiquitination(GO:0016579)
0.1 1.7 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 3.6 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.1 1.0 GO:0000755 cytogamy(GO:0000755)
0.1 0.3 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.1 0.3 GO:0016241 regulation of macroautophagy(GO:0016241)
0.1 0.5 GO:0019433 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.1 3.4 GO:0009060 aerobic respiration(GO:0009060)
0.1 1.4 GO:0032258 CVT pathway(GO:0032258)
0.1 0.3 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.2 GO:0052652 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.1 1.0 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.3 GO:0042407 cristae formation(GO:0042407)
0.1 0.2 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.1 3.0 GO:0007031 peroxisome organization(GO:0007031)
0.1 0.2 GO:0019748 secondary metabolic process(GO:0019748)
0.1 0.2 GO:0045117 azole transport(GO:0045117)
0.1 0.4 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.3 GO:0071168 protein localization to chromatin(GO:0071168)
0.1 0.2 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 0.2 GO:0046113 nucleobase catabolic process(GO:0046113)
0.1 1.4 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 3.0 GO:0070590 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.5 GO:0070058 tRNA gene clustering(GO:0070058)
0.1 0.2 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.1 1.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.1 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.2 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.1 GO:0000304 response to singlet oxygen(GO:0000304)
0.1 0.1 GO:0030007 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.1 0.1 GO:0071400 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.1 0.3 GO:0043954 cellular component maintenance(GO:0043954)
0.1 0.2 GO:0031297 replication fork processing(GO:0031297)
0.1 0.5 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 0.4 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.1 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.1 0.3 GO:0006241 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.1 0.2 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.1 0.3 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.4 GO:0070272 proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.1 0.1 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.1 0.4 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 0.7 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.1 GO:0072485 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.0 0.7 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.1 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.1 GO:0036257 multivesicular body organization(GO:0036257)
0.0 0.6 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0 0.2 GO:0042732 D-xylose metabolic process(GO:0042732)
0.0 0.2 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.0 0.1 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.0 0.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.4 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.1 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 0.1 GO:2001023 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.3 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.0 0.2 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.0 0.1 GO:0034755 high-affinity iron ion transmembrane transport(GO:0006827) iron ion transmembrane transport(GO:0034755)
0.0 0.4 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.1 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.0 0.2 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.1 GO:0006631 fatty acid metabolic process(GO:0006631)
0.0 0.4 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.5 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0006739 NADP metabolic process(GO:0006739)
0.0 0.1 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.2 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 1.3 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.1 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.1 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.0 0.1 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.5 GO:0022900 electron transport chain(GO:0022900)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.9 GO:0072666 protein targeting to vacuole(GO:0006623) establishment of protein localization to vacuole(GO:0072666)
0.0 0.2 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.2 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.0 0.2 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.2 GO:0019740 nitrogen utilization(GO:0019740)
0.0 0.0 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.2 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.2 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.0 0.2 GO:0015918 sterol transport(GO:0015918)
0.0 0.6 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.1 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0006626 protein targeting to mitochondrion(GO:0006626) protein localization to mitochondrion(GO:0070585) establishment of protein localization to mitochondrion(GO:0072655)
0.0 0.2 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.2 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.3 GO:0006112 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.0 0.0 GO:0019400 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.0 0.0 GO:0071616 acetyl-CoA biosynthetic process(GO:0006085) acetyl-CoA biosynthetic process from pyruvate(GO:0006086) thioester biosynthetic process(GO:0035384) acyl-CoA biosynthetic process(GO:0071616)
0.0 0.2 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.0 GO:0042173 regulation of sporulation resulting in formation of a cellular spore(GO:0042173)
0.0 0.0 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.0 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.8 7.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.8 7.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.6 1.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.6 1.7 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.5 1.6 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.5 1.6 GO:0046930 pore complex(GO:0046930)
0.5 1.6 GO:0045240 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.5 1.5 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.4 3.5 GO:0042597 periplasmic space(GO:0042597)
0.3 1.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.3 5.4 GO:0070469 respiratory chain(GO:0070469)
0.3 1.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.3 1.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.3 0.8 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.3 17.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 1.0 GO:0031901 early endosome membrane(GO:0031901)
0.2 1.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 1.7 GO:0005769 early endosome(GO:0005769)
0.2 0.5 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.2 1.3 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.2 2.5 GO:0031160 spore wall(GO:0031160)
0.2 4.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 0.5 GO:0031226 intrinsic component of plasma membrane(GO:0031226) anchored component of plasma membrane(GO:0046658)
0.1 21.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 2.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 2.0 GO:0033698 Rpd3L complex(GO:0033698)
0.1 0.9 GO:0034657 GID complex(GO:0034657)
0.1 0.7 GO:0032126 eisosome(GO:0032126)
0.1 0.3 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 0.5 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 2.2 GO:0031201 SNARE complex(GO:0031201)
0.1 0.5 GO:0031262 Ndc80 complex(GO:0031262)
0.1 3.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.0 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 0.2 GO:0031207 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.1 0.5 GO:0098798 mitochondrial protein complex(GO:0098798)
0.1 0.2 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 1.0 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.4 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.3 GO:0008623 CHRAC(GO:0008623)
0.1 1.4 GO:0016592 mediator complex(GO:0016592)
0.1 0.4 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.4 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.1 6.0 GO:0005740 mitochondrial envelope(GO:0005740)
0.1 0.4 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 0.6 GO:0000974 Prp19 complex(GO:0000974)
0.1 0.2 GO:0070274 RES complex(GO:0070274)
0.1 0.1 GO:0070211 Snt2C complex(GO:0070211)
0.1 0.2 GO:0034099 luminal surveillance complex(GO:0034099)
0.1 0.2 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.4 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.2 GO:0033309 SBF transcription complex(GO:0033309)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.7 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.0 0.2 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.0 0.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.2 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 11.2 GO:0005739 mitochondrion(GO:0005739)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0001400 mating projection base(GO:0001400)
0.0 0.2 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.3 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.0 9.9 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 8.9 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
1.6 6.5 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.4 5.8 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
1.4 6.8 GO:0015295 solute:proton symporter activity(GO:0015295)
1.1 3.4 GO:0016289 CoA hydrolase activity(GO:0016289)
1.0 4.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.9 10.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.9 2.7 GO:0005536 glucose binding(GO:0005536)
0.8 4.2 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.8 3.4 GO:0005537 mannose binding(GO:0005537)
0.8 2.4 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.7 2.2 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.7 5.3 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.7 12.0 GO:0015297 antiporter activity(GO:0015297)
0.6 1.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.6 1.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.6 2.9 GO:0008198 ferrous iron binding(GO:0008198)
0.5 1.6 GO:0008308 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.5 1.4 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.5 3.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 1.8 GO:0004396 hexokinase activity(GO:0004396)
0.4 1.3 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.4 2.4 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 1.6 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.4 3.6 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.4 1.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.4 1.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.4 1.5 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.4 2.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379) peroxiredoxin activity(GO:0051920)
0.3 4.1 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.3 2.7 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.3 3.2 GO:0035064 methylated histone binding(GO:0035064)
0.3 2.6 GO:0099600 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.3 1.7 GO:0000400 four-way junction DNA binding(GO:0000400)
0.3 0.6 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.3 3.3 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.3 1.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.3 2.3 GO:0015293 symporter activity(GO:0015293)
0.2 3.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 0.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 1.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 3.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 2.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2 1.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.2 1.3 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.2 0.6 GO:0048038 quinone binding(GO:0048038)
0.2 0.6 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.2 0.8 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.2 2.7 GO:0070566 adenylyltransferase activity(GO:0070566)
0.2 0.6 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 1.0 GO:0070403 NAD+ binding(GO:0070403)
0.2 0.5 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.2 0.2 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.2 1.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.5 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.2 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 0.5 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.2 1.2 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.2 0.8 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.2 0.8 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.6 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.1 0.4 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.1 0.5 GO:0016531 copper chaperone activity(GO:0016531)
0.1 0.5 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.1 0.4 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 0.3 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.1 0.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 0.3 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.1 0.5 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 1.2 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 0.3 GO:0032183 SUMO binding(GO:0032183)
0.1 0.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.4 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.2 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.1 0.7 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.1 1.1 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 2.3 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 0.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 3.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 1.2 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 1.5 GO:0016298 lipase activity(GO:0016298)
0.1 0.4 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 0.7 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.1 1.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 3.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 1.5 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.2 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.1 1.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.2 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.1 0.9 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.6 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.1 2.0 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.1 1.9 GO:0043492 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.6 GO:0010181 FMN binding(GO:0010181)
0.1 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.2 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 0.3 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 0.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.3 GO:0001004 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.1 0.7 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 0.2 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.3 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.2 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.2 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.0 0.1 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.0 0.5 GO:0050661 NADP binding(GO:0050661)
0.0 0.1 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.2 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.1 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.3 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.7 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.0 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.1 GO:0016597 amino acid binding(GO:0016597)
0.0 0.6 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.4 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 2.9 GO:0004672 protein kinase activity(GO:0004672)
0.0 0.1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0015405 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405)
0.0 0.0 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.0 0.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.2 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.2 GO:0022838 substrate-specific channel activity(GO:0022838)
0.0 0.1 GO:0016878 AMP binding(GO:0016208) CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.2 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 0.1 GO:0005507 copper ion binding(GO:0005507)
0.0 0.2 GO:0019900 kinase binding(GO:0019900)
0.0 0.1 GO:0034979 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 1.1 PID FOXO PATHWAY FoxO family signaling
0.4 1.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.4 1.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 1.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 0.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 67.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.1 PID AURORA B PATHWAY Aurora B signaling
0.0 0.0 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 9.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.9 2.7 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.5 1.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.5 1.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.4 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 0.6 REACTOME MEIOSIS Genes involved in Meiosis
0.1 0.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 0.2 REACTOME INNATE IMMUNE SYSTEM Genes involved in Innate Immune System
0.1 0.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 66.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.0 0.0 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 0.1 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.0 0.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane