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Results for PHD1

Z-value: 0.98

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Transcription factors associated with PHD1

Gene Symbol Gene ID Gene Info
PHD1
S000001526 Transcriptional activator that enhances pseudohyphal growth

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PHD1YKL043W0.905.9e-10Click!

Activity profile of PHD1 motif

Sorted Z-values of PHD1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YMR017W 20.40
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YAR053W 12.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFL051C 11.61 Putative protein of unknown function; YFL051C is not an essential gene
YAL062W 10.02
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YDR536W 9.70
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YOR100C 9.54
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YAR060C 9.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL217W 9.16
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YDL210W 7.95
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YMR206W 7.27 Putative protein of unknown function; YMR206W is not an essential gene
YKL044W 6.82 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR212C 6.51 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR212W-A 6.07 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLR311C 5.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFL052W 5.83 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YPR192W 5.75
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YMR244W 5.49 Putative protein of unknown function
YKL163W 5.43
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YKL043W 5.15
PHD1
Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YHR211W 5.15
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YJR146W 4.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YER158C 4.80 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YDR119W-A 4.50 Putative protein of unknown function
YMR107W 4.48
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YGR065C 4.30
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YLR327C 4.29
TMA10
Protein of unknown function that associates with ribosomes
YGR032W 4.20
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YML042W 4.18
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YCR021C 4.16
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YCL025C 4.12
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YBR072W 4.10
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YOR343C 4.10 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YMR081C 3.82
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YEL009C 3.73
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YEL070W 3.73
DSF1
Deletion suppressor of mpt5 mutation
YEL008W 3.70 Hypothetical protein predicted to be involved in metabolism
YAR050W 3.60
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YGL258W-A 3.39 Putative protein of unknown function
YLR312C 3.33
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YBR296C 3.24
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YGL096W 3.24
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YAR047C 3.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR092C 3.03
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YDR542W 3.01
PAU10
Hypothetical protein
YNL144C 2.99 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YPR013C 2.97 Putative zinc finger protein; YPR013C is not an essential gene
YJR115W 2.95 Putative protein of unknown function
YLR023C 2.88
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YGR213C 2.87
RTA1
Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions
YLR004C 2.86
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YJR048W 2.85
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YAL034C 2.77
FUN19
Non-essential protein of unknown function
YAL063C 2.75
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YPR154W 2.72
PIN3
Protein that induces appearance of [PIN+] prion when overproduced
YOR152C 2.72 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YNL180C 2.71
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YKL026C 2.68
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YDR014W-A 2.62
HED1
Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YLR334C 2.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
YBR250W 2.61
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YEL074W 2.61 Hypothetical protein
YDL127W 2.61
PCL2
G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth
YLL060C 2.59
GTT2
Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YCR091W 2.57
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YNL179C 2.56 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YBL043W 2.53
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YNL195C 2.53 Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR387C 2.52 Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YLR053C 2.49 Putative protein of unknown function
YLR235C 2.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3
YER088C 2.44
DOT6
Protein of unknown function, involved in telomeric gene silencing and filamentation
YFR053C 2.41
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YNL117W 2.40
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YOR178C 2.40
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YOR072W 2.40 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YPL024W 2.39
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YGL062W 2.38
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YMR135C 2.36
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YLR236C 2.30 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR210C 2.29 Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YHR033W 2.28 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YGL045W 2.26
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YGR243W 2.22
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR034C 2.22
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YPL187W 2.21
MF(ALPHA)1
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
YOR072W-A 2.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YIR039C 2.21
YPS6
Putative GPI-anchored aspartic protease
YFL063W 2.18 Dubious open reading frame, based on available experimental and comparative sequence data
YER084W 2.18 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL244W 2.17
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YEL075C 2.17 Putative protein of unknown function
YFL064C 2.16 Putative protein of unknown function
YBL049W 2.14
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YNR064C 2.13 Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
YOL084W 2.10
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YMR250W 2.08
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YOR071C 2.08
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YHR139C 2.08
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YPL258C 2.07
THI21
Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
YDR540C 2.07
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YPL223C 2.06
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YNL142W 2.02
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YDR541C 2.02 Putative dihydrokaempferol 4-reductase
YDR342C 2.02
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YNR073C 2.01 Putative mannitol dehydrogenase
YHR138C 1.98 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YLR237W 1.97
THI7
Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YJL037W 1.94
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YIL122W 1.94
POG1
Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YJR147W 1.93
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YPL018W 1.92
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YFL062W 1.89
COS4
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YDR022C 1.89
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YLR393W 1.88
ATP10
Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
YPL026C 1.86
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YHL040C 1.86
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YMR194C-B 1.85 Putative protein of unknown function
YDR009W 1.84
GAL3
Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
YKR102W 1.83
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YPL186C 1.83
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YLL029W 1.82
FRA1
Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
YMR280C 1.82
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YNL052W 1.80
COX5A
Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YIL057C 1.78 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YDR231C 1.77
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YIL077C 1.76 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YLL053C 1.74 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YPL185W 1.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YKL107W 1.72 Putative protein of unknown function
YKL103C 1.72
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YDR258C 1.70
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YER101C 1.69
AST2
Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YOR192C 1.69
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YLR332W 1.68
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YLR331C 1.68
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YOR339C 1.66
UBC11
Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2
YJL133C-A 1.64 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAL039C 1.64
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YFR026C 1.60 Putative protein of unknown function
YER162C 1.59
RAD4
Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
YDR218C 1.59
SPR28
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
YER033C 1.59
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YOR192C-C 1.58 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YJR128W 1.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YEL059W 1.56 Dubious open reading frame unlikely to encode a functional protein
YDL079C 1.56
MRK1
Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YGL208W 1.55
SIP2
One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
YKL038W 1.54
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YDR259C 1.54
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YJL217W 1.53 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YKL028W 1.51
TFA1
TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YLL052C 1.51
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YLR136C 1.49
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YJR152W 1.48
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YOR221C 1.46
MCT1
Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling
YOL118C 1.46 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YBR001C 1.45
NTH2
Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses
YHR075C 1.44
PPE1
Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
YPL017C 1.44
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YGL163C 1.43
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YPR036W-A 1.42 Protein of unknown function; transcription is regulated by Pdr1p
YOR023C 1.41
AHC1
Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
YOR346W 1.40
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YNL143C 1.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR145C 1.39 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR296W 1.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL189C-A 1.39
COA2
Putative cytochrome oxidase assembly factor; identified by homology to Ashbya gossypii; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity
YDR124W 1.38 Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
YNR063W 1.36 Putative zinc-cluster protein of unknown function
YCR025C 1.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YLR295C 1.36
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YMR316C-B 1.35 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL058W 1.34
THI5
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YER121W 1.34 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YOR147W 1.33
MDM32
Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YLR356W 1.32 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YDR043C 1.32
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YEL007W 1.31 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YJL038C 1.30
LOH1
Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W
YDR232W 1.30
HEM1
5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YER187W 1.29 Putative protein of unknown function; induced in respiratory-deficient cells
YML120C 1.29
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YJR150C 1.28
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YHL046W-A 1.27 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL045C 1.26
COR1
Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YHR096C 1.26
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YPR202W 1.26 Putative protein of unknown function with similarity to telomere-encoded helicases; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
YKL198C 1.26
PTK1
Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein
YKL102C 1.26 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YDL011C 1.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YMR317W 1.25 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YNL332W 1.25
THI12
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YDL010W 1.24
GRX6
Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX6
YHR053C 1.24
CUP1-1
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YMR090W 1.22 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YJR138W 1.21
IML1
Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YDR102C 1.21 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YLR122C 1.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YBL039W-B 1.20 Putative protein of unknown function
YMR056C 1.20
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator

Network of associatons between targets according to the STRING database.

First level regulatory network of PHD1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 8.9 GO:0019676 ammonia assimilation cycle(GO:0019676)
2.8 11.4 GO:0006848 pyruvate transport(GO:0006848)
2.0 8.0 GO:0015847 putrescine transport(GO:0015847)
2.0 11.8 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
1.9 5.7 GO:0015888 thiamine transport(GO:0015888)
1.9 9.5 GO:0015793 glycerol transport(GO:0015793)
1.7 5.2 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
1.4 5.8 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
1.4 4.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.3 19.4 GO:0031321 ascospore-type prospore assembly(GO:0031321)
1.2 4.8 GO:0046323 glucose import(GO:0046323)
0.9 2.8 GO:0043335 protein unfolding(GO:0043335)
0.9 2.7 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.9 3.6 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.8 2.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.8 3.9 GO:0051180 vitamin transport(GO:0051180)
0.8 2.3 GO:0006538 glutamate catabolic process(GO:0006538)
0.7 3.0 GO:0000435 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.7 3.5 GO:0034486 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.7 2.1 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.7 2.7 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.7 2.7 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.6 5.8 GO:0006097 glyoxylate cycle(GO:0006097)
0.6 5.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.6 1.7 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.6 0.6 GO:0072353 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
0.5 1.6 GO:0045117 azole transport(GO:0045117)
0.5 1.6 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.5 2.1 GO:0046688 response to copper ion(GO:0046688)
0.5 2.0 GO:0015886 heme transport(GO:0015886)
0.5 8.5 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.5 4.4 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.5 2.0 GO:0035968 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.5 1.4 GO:0005993 trehalose catabolic process(GO:0005993)
0.5 1.9 GO:0019748 secondary metabolic process(GO:0019748)
0.5 1.4 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.5 4.6 GO:0043461 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.5 1.8 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.4 0.4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.4 3.8 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.4 0.8 GO:0042819 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.4 1.2 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.4 2.0 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.4 1.2 GO:0006824 cobalt ion transport(GO:0006824)
0.4 1.1 GO:0061727 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.3 1.0 GO:0009732 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.3 3.0 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.3 2.7 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.3 0.3 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.3 0.6 GO:0000101 sulfur amino acid transport(GO:0000101)
0.3 2.8 GO:0045332 phospholipid translocation(GO:0045332)
0.3 0.3 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.3 0.3 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993)
0.3 1.2 GO:0000023 maltose metabolic process(GO:0000023)
0.3 2.6 GO:0046352 disaccharide catabolic process(GO:0046352)
0.3 2.6 GO:0051318 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318)
0.3 2.0 GO:0009749 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.3 1.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 0.8 GO:0034090 maintenance of meiotic sister chromatid cohesion(GO:0034090)
0.3 1.6 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.3 0.8 GO:0006108 malate metabolic process(GO:0006108)
0.3 0.8 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.3 3.4 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.2 0.2 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.2 3.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.2 3.4 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.2 3.8 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.2 3.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 0.9 GO:0019388 galactose catabolic process(GO:0019388)
0.2 1.6 GO:0015891 siderophore transport(GO:0015891)
0.2 5.2 GO:0098656 anion transmembrane transport(GO:0098656)
0.2 1.1 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.2 0.7 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.2 0.7 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.2 1.1 GO:0005980 glycogen catabolic process(GO:0005980)
0.2 0.7 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.2 1.3 GO:0051260 protein homooligomerization(GO:0051260)
0.2 2.4 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 0.2 GO:0000736 removal of nonhomologous ends(GO:0000735) double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.2 1.6 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.2 2.1 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.2 3.5 GO:0007266 Rho protein signal transduction(GO:0007266)
0.2 0.2 GO:0070726 cell wall assembly(GO:0070726)
0.2 0.9 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.2 0.9 GO:0006829 zinc II ion transport(GO:0006829)
0.2 3.1 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.2 0.4 GO:0072366 regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.2 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 0.7 GO:0006171 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.2 0.4 GO:0043270 positive regulation of ion transport(GO:0043270)
0.2 1.4 GO:0046686 response to cadmium ion(GO:0046686)
0.2 9.6 GO:0009060 aerobic respiration(GO:0009060)
0.2 1.4 GO:0018345 protein palmitoylation(GO:0018345)
0.2 0.8 GO:0043605 cellular amide catabolic process(GO:0043605)
0.2 0.6 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 0.5 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.2 1.3 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.2 1.1 GO:0031647 regulation of protein stability(GO:0031647)
0.2 0.5 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.2 0.2 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.2 1.4 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 0.3 GO:0042148 strand invasion(GO:0042148)
0.1 1.9 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.1 1.0 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.1 0.4 GO:0006311 meiotic gene conversion(GO:0006311)
0.1 0.4 GO:0008272 sulfate transport(GO:0008272)
0.1 1.1 GO:0006638 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.1 0.3 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 0.4 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.1 1.2 GO:0016233 telomere capping(GO:0016233)
0.1 0.8 GO:0051322 anaphase(GO:0051322)
0.1 0.3 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
0.1 0.5 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 2.5 GO:0006094 gluconeogenesis(GO:0006094)
0.1 0.8 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.5 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.1 0.4 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 0.6 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.4 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.7 GO:0010038 response to metal ion(GO:0010038)
0.1 1.5 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.5 GO:0000755 cytogamy(GO:0000755)
0.1 0.4 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.1 0.1 GO:0051098 regulation of binding(GO:0051098)
0.1 0.2 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.1 0.6 GO:0051274 beta-glucan biosynthetic process(GO:0051274)
0.1 0.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.3 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.1 0.4 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.4 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 0.4 GO:0034508 centromere complex assembly(GO:0034508) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.1 0.6 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.5 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.1 0.2 GO:0072348 sulfur compound transport(GO:0072348)
0.1 2.5 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 2.1 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 1.4 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 0.3 GO:0030048 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 2.3 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.5 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.3 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.1 0.1 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.1 0.6 GO:0070058 tRNA gene clustering(GO:0070058)
0.1 0.2 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 0.5 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 0.2 GO:0015856 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.1 0.5 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 0.6 GO:0007118 budding cell apical bud growth(GO:0007118)
0.1 0.8 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 0.4 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.2 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 0.4 GO:0030308 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.1 0.5 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.2 GO:0044209 AMP salvage(GO:0044209)
0.1 0.3 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.4 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.6 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.6 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 3.4 GO:0007031 peroxisome organization(GO:0007031)
0.1 0.3 GO:0070941 eisosome assembly(GO:0070941)
0.1 0.2 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.1 0.3 GO:0009208 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.1 0.3 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.1 0.8 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 0.2 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.1 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.4 GO:0043488 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.1 0.2 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.1 1.0 GO:0000001 mitochondrion inheritance(GO:0000001) mitochondrion distribution(GO:0048311)
0.1 0.4 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 0.7 GO:0043486 histone exchange(GO:0043486)
0.1 0.9 GO:0007129 synapsis(GO:0007129)
0.1 0.2 GO:0009249 protein lipoylation(GO:0009249)
0.1 0.1 GO:0051230 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.1 1.0 GO:0015850 organic hydroxy compound transport(GO:0015850)
0.1 0.2 GO:0031297 replication fork processing(GO:0031297)
0.1 0.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 0.1 GO:0006546 glycine catabolic process(GO:0006546)
0.1 0.3 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.2 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 1.7 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 4.7 GO:0030435 sporulation resulting in formation of a cellular spore(GO:0030435) anatomical structure formation involved in morphogenesis(GO:0048646)
0.0 0.1 GO:0071398 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.0 0.2 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.3 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 0.3 GO:0046337 phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.0 GO:0018206 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.0 0.2 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.0 0.4 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.1 GO:0015851 nucleobase transport(GO:0015851)
0.0 0.1 GO:0036257 multivesicular body organization(GO:0036257)
0.0 0.7 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.6 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.0 0.1 GO:0009187 cyclic nucleotide metabolic process(GO:0009187)
0.0 0.5 GO:0042026 protein refolding(GO:0042026)
0.0 0.4 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.2 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.2 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.4 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.4 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.2 GO:0006284 base-excision repair(GO:0006284)
0.0 0.1 GO:0005977 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.0 0.1 GO:0060195 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.0 1.0 GO:0043254 regulation of protein complex assembly(GO:0043254)
0.0 1.2 GO:0018393 internal protein amino acid acetylation(GO:0006475) histone acetylation(GO:0016573) internal peptidyl-lysine acetylation(GO:0018393) peptidyl-lysine acetylation(GO:0018394)
0.0 0.4 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.1 GO:0019932 second-messenger-mediated signaling(GO:0019932)
0.0 0.3 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.2 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.0 0.2 GO:1902222 L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.4 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 0.5 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.3 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.1 GO:2001023 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.0 0.1 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.0 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.0 0.4 GO:0012501 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.0 0.0 GO:0045595 regulation of cell differentiation(GO:0045595)
0.0 0.2 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.2 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.0 0.1 GO:0006545 glycine biosynthetic process(GO:0006545)
0.0 0.5 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.1 GO:0006721 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0006826 iron ion transport(GO:0006826)
0.0 0.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.0 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.0 0.3 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 5.8 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.8 1.7 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.8 20.2 GO:0031201 SNARE complex(GO:0031201)
0.8 2.4 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.6 1.9 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.5 6.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.5 1.9 GO:0000817 COMA complex(GO:0000817)
0.5 3.3 GO:0034657 GID complex(GO:0034657)
0.4 1.8 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.4 0.8 GO:0030061 mitochondrial crista(GO:0030061)
0.4 1.2 GO:0005796 Golgi lumen(GO:0005796)
0.4 3.7 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.4 1.1 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.4 1.1 GO:0001400 mating projection base(GO:0001400)
0.3 2.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 1.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.3 8.3 GO:0070469 respiratory chain(GO:0070469)
0.3 1.3 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.2 0.5 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 1.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 3.1 GO:0005619 ascospore wall(GO:0005619)
0.2 0.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 0.6 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.2 0.6 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.2 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 1.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 25.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 0.5 GO:0005784 Sec61 translocon complex(GO:0005784)
0.2 0.5 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 6.9 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.1 GO:0000974 Prp19 complex(GO:0000974)
0.1 0.6 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.1 1.4 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.4 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.1 0.4 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.8 GO:0005775 vacuolar lumen(GO:0005775)
0.1 0.3 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.7 GO:0032126 eisosome(GO:0032126)
0.1 0.8 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 12.0 GO:0000329 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.1 3.5 GO:0000131 incipient cellular bud site(GO:0000131)
0.1 0.5 GO:0044233 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 32.1 GO:0005886 plasma membrane(GO:0005886)
0.1 0.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.6 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 2.9 GO:0030479 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.1 1.1 GO:0033698 Rpd3L complex(GO:0033698)
0.1 0.7 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.4 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.2 GO:0016587 Isw1 complex(GO:0016587)
0.1 1.5 GO:0044463 cell projection part(GO:0044463)
0.1 0.4 GO:0031211 palmitoyltransferase complex(GO:0002178) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.7 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 6.2 GO:0005740 mitochondrial envelope(GO:0005740)
0.0 0.6 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.1 GO:0035649 Nrd1 complex(GO:0035649)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 1.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.2 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.0 0.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.3 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0019867 outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.6 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0030869 RENT complex(GO:0030869)
0.0 0.2 GO:0097346 Ino80 complex(GO:0031011) INO80-type complex(GO:0097346)
0.0 0.0 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 1.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.3 GO:0042764 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.0 0.2 GO:0098798 mitochondrial protein complex(GO:0098798)
0.0 0.2 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.0 GO:0005955 calcineurin complex(GO:0005955)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 27.2 GO:0015295 solute:proton symporter activity(GO:0015295)
3.3 13.3 GO:0005537 mannose binding(GO:0005537)
2.3 9.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.9 5.8 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
1.7 5.2 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
1.2 3.6 GO:1901474 azole transmembrane transporter activity(GO:1901474)
1.0 3.1 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
1.0 3.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.9 3.8 GO:0004396 hexokinase activity(GO:0004396)
0.8 20.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.8 9.2 GO:0022838 substrate-specific channel activity(GO:0022838)
0.7 2.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.7 2.9 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.7 2.1 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.7 2.0 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.7 0.7 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.6 2.6 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.6 2.4 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.5 1.1 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.5 4.2 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.5 1.4 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.5 3.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.5 1.9 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.5 5.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5 2.3 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.4 1.8 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.4 0.9 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.4 2.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.4 1.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.4 2.3 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 1.1 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.4 3.4 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.4 7.3 GO:0015297 antiporter activity(GO:0015297)
0.3 3.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 1.0 GO:0005536 glucose binding(GO:0005536)
0.3 2.0 GO:0015293 symporter activity(GO:0015293)
0.3 1.0 GO:0015658 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.3 0.9 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.3 0.9 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.3 1.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 1.2 GO:0015037 glutathione-disulfide reductase activity(GO:0004362) peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.3 2.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 2.4 GO:0031072 heat shock protein binding(GO:0031072)
0.3 0.8 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.3 1.1 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.3 0.8 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.3 0.8 GO:0048038 quinone binding(GO:0048038)
0.3 0.8 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.3 0.8 GO:0016208 AMP binding(GO:0016208)
0.3 2.5 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 1.0 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.2 1.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.2 2.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 0.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.2 0.7 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 2.2 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.2 1.7 GO:0099600 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.2 1.7 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 0.4 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.2 0.8 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.2 0.2 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.2 0.8 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.2 2.2 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.2 0.6 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.2 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 0.4 GO:0016530 metallochaperone activity(GO:0016530)
0.2 0.9 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.2 0.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 4.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.2 2.4 GO:0005507 copper ion binding(GO:0005507)
0.2 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.2 0.8 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 0.5 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.2 0.6 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 0.3 GO:0015103 inorganic anion transmembrane transporter activity(GO:0015103)
0.2 0.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.4 GO:0008198 ferrous iron binding(GO:0008198)
0.1 1.6 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 6.7 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.4 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 1.2 GO:0016722 oxidoreductase activity, oxidizing metal ions(GO:0016722)
0.1 0.4 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 0.7 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.1 0.8 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 1.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.7 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 8.0 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 2.9 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 0.5 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.7 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 1.1 GO:0015036 protein disulfide oxidoreductase activity(GO:0015035) disulfide oxidoreductase activity(GO:0015036)
0.1 0.7 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.3 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.5 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.2 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128)
0.1 0.8 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.2 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 1.4 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.1 1.4 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.4 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 1.0 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 1.6 GO:0005509 calcium ion binding(GO:0005509)
0.1 0.2 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.1 0.5 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 0.4 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 1.9 GO:0003684 damaged DNA binding(GO:0003684)
0.1 1.2 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 1.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.5 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1 0.4 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.8 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.3 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.1 0.2 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.1 0.7 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.3 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 0.2 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.2 GO:0019903 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.0 0.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.2 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 5.1 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.7 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0001091 core promoter binding(GO:0001047) RNA polymerase II basal transcription factor binding(GO:0001091)
0.0 0.2 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.2 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.0 0.2 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.7 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.1 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.2 GO:0050661 NADP binding(GO:0050661)
0.0 0.0 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.0 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 0.1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.0 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.0 GO:0044212 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
0.0 0.2 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 PID NOTCH PATHWAY Notch signaling pathway
0.3 1.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 0.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 0.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 0.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 0.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 0.3 PID FOXO PATHWAY FoxO family signaling
0.1 151.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.0 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.5 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 0.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 0.5 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.1 148.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.4 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.1 0.4 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 0.3 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.0 0.1 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.1 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.0 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.1 REACTOME MEIOSIS Genes involved in Meiosis