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Results for RAP1

Z-value: 8.56

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Transcription factors associated with RAP1

Gene Symbol Gene ID Gene Info
RAP1
S000005160 Essential DNA-binding transcription regulator that binds at many loci

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RAP1YNL216W0.491.0e-02Click!

Activity profile of RAP1 motif

Sorted Z-values of RAP1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YJR094W-A 98.78
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YNL338W 82.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YER117W 70.57
RPL23B
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YFR055W 69.31
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YLR167W 65.79
RPS31
Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
YPL250W-A 65.11 Identified by fungal homology and RT-PCR
YOR293W 64.33
RPS10A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
YHL015W 63.89
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YMR142C 63.24
RPL13B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YPL079W 63.12
RPL21B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein
YMR143W 62.45
RPS16A
Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YIL018W 62.04
RPL2B
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures
YFR056C 61.42 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YPL090C 60.33
RPS6A
Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YDR471W 60.23
RPL27B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
YOR096W 58.94
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YDL082W 57.68
RPL13A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein
YGR034W 56.78
RPL26B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YGL103W 56.25
RPL28
Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
YJL177W 55.73
RPL17B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
YGR148C 55.70
RPL24B
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YHR141C 55.21
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YDL083C 55.01
RPS16B
Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins
YBR181C 54.69
RPS6B
Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YNL337W 54.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL190C 54.10
RPS22A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YGR214W 52.39
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YLR448W 52.17
RPL6B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YBR048W 51.24
RPS11B
Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YDR033W 51.00
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YER131W 50.80
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YOL127W 50.67
RPL25
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YJL136C 50.28
RPS21B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YDR447C 50.08
RPS17B
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YEL054C 49.51
RPL12A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YDR418W 48.68
RPL12B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YGL135W 48.01
RPL1B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YKR094C 47.39
RPL40B
Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YER056C-A 47.28
RPL34A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
YJR145C 46.33
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YML073C 46.32
RPL6A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
YNL069C 45.96
RPL16B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YOL121C 45.83
RPS19A
Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp
YML024W 45.53
RPS17A
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein
YFR031C-A 45.08
RPL2A
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YOL086C 44.86
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YBR189W 44.06
RPS9B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins
YDR064W 43.71
RPS13
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins
YGL076C 43.60
RPL7A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YBL092W 43.07
RPL32
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YLR441C 42.92
RPS1A
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
YDR025W 42.91
RPS11A
Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YIL052C 42.52
RPL34B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YGR027C 41.71
RPS25A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YPR132W 41.33
RPS23B
Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YPR102C 41.01
RPL11A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YGL189C 40.95
RPS26A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein
YML063W 40.76
RPS1B
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YGR118W 40.73
RPS23A
Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YLR061W 40.30
RPL22A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein
YPL037C 39.96
EGD1
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YML026C 39.57
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YBR118W 38.75
TEF2
Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YOR234C 38.12
RPL33B
Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YBR084C-A 38.06
RPL19A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YLR154C 37.54
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YGL123C-A 36.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YGL123W 36.58
RPS2
Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YLR048W 36.51
RPS0B
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YGR108W 36.40
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YNL162W 35.64
RPL42A
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein
YER074W 35.33
RPS24A
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YLR029C 35.24
RPL15A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YBR191W 35.01
RPL21A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein
YDL136W 34.91
RPL35B
Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein
YKR092C 34.20
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YLL045C 34.11
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YDL191W 34.10
RPL35A
Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YHR021C 33.55
RPS27B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YMR106C 33.35
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YKL180W 33.32
RPL17A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YNL339C 32.56
YRF1-6
Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YDR450W 32.35
RPS18A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YIL053W 32.25
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YHR203C 32.20
RPS4B
Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YLR325C 32.10
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YOL120C 31.51
RPL18A
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation
YDL075W 31.46
RPL31A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YMR116C 31.45
ASC1
G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
YOR101W 30.88
RAS1
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YGR085C 30.58
RPL11B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YNL178W 30.24
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YFL034C-A 30.22
RPL22B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein
YNR013C 29.56
PHO91
Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YGL031C 29.55
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YJR123W 29.24
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YGL147C 29.06
RPL9A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YLR154W-B 29.06 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YHR010W 29.04
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YBL027W 28.84
RPL19B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YLR154W-A 28.76 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR110C 28.32
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YLR344W 28.23
RPL26A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YKL030W 28.17 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
YDL055C 27.88
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YER031C 27.84
YPT31
GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YNL336W 27.58
COS1
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YBR085W 27.26
AAC3
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YPL131W 26.93
RPL5
Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly
YLR400W 26.83 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR032C-A 26.52
RPL29
Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate
YOR312C 26.31
RPL20B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
YGR052W 25.67
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR194W 25.57
RPL36A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YPL143W 25.47
RPL33A
N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YER102W 25.35
RPS8B
Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YBL028C 25.34 Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YOL039W 25.33
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YBL087C 25.11
RPL23A
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
YGL030W 25.04
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YLR333C 24.17
RPS25B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YLR312W-A 24.02
MRPL15
Mitochondrial ribosomal protein of the large subunit
YAL038W 23.64
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YHL033C 23.63
RPL8A
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YMR141W-A 23.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C
YGR259C 23.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YOL040C 22.94
RPS15
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YNL096C 22.67
RPS7B
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YGR050C 22.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHL001W 22.56
RPL14B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein
YFL015W-A 22.35 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR339C 22.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
YDR279W 22.04
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YAL003W 21.87
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YCR031C 21.39
RPS14A
Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YGR060W 21.32
ERG25
C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YLR340W 21.09
RPP0
Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302
YIL148W 20.98
RPL40A
Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YFL015C 20.92 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YFL022C 20.89
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YLR075W 20.79
RPL10
Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YHR181W 20.78
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YMR230W 20.59
RPS10B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10
YDR500C 19.94
RPL37B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
YLR154W-C 19.88
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YMR083W 19.56
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YKR057W 19.43
RPS21A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein
YLR185W 19.39
RPL37A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YPL249C-A 19.28
RPL36B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YKL152C 19.05
GPM1
Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YLR183C 18.95
TOS4
Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YEL068C 18.95 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL085C 18.72 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YOR369C 18.22
RPS12
Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YFR054C 17.57 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER032W 17.56
FIR1
Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
YGR192C 17.50
TDH3
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YMR183C 17.43
SSO2
Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YMR205C 17.41
PFK2
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YER130C 17.14 Hypothetical protein
YOR315W 17.05
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YJR094C 16.98
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YGR051C 16.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YDR041W 16.86
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YKL081W 16.60
TEF4
Translation elongation factor EF-1 gamma
YHR142W 16.57
CHS7
Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
YGR234W 16.56
YHB1
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YLR003C 16.46 Putative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene
YHR032W-A 16.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A
YGR253C 16.27
PUP2
Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YDR188W 16.20
CCT6
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
YPR063C 16.10 ER-localized protein of unknown function
YDR449C 16.08
UTP6
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YCL024W 15.99
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YNL024C 15.98 Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene
YDR037W 15.88
KRS1
Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YDR133C 15.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YLR388W 15.78
RPS29A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YLR300W 15.65
EXG1
Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YLR287C-A 15.48
RPS30A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein
YDL023C 15.35 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YEL056W 15.24
HAT2
Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YLR401C 15.18
DUS3
Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region
YGR260W 15.12
TNA1
High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YDR044W 15.09
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YPR080W 14.99
TEF1
Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YPL227C 14.98
ALG5
UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
YPR029C 14.96
APL4
Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YHR180W-A 14.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YDR040C 14.74
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YAL033W 14.73
POP5
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YBR190W 14.71 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
YNL302C 14.71
RPS19B
Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap
YDR187C 14.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
YDR112W 14.61
IRC2
Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
YML064C 14.57
TEM1
GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
YFR028C 14.39
CDC14
Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit
YEL066W 14.24
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YLR249W 14.18
YEF3
Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YPR131C 14.12
NAT3
Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met

Network of associatons between targets according to the STRING database.

First level regulatory network of RAP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
39.7 158.6 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
36.8 147.1 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
27.1 434.4 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
25.5 3497.0 GO:0002181 cytoplasmic translation(GO:0002181)
23.1 69.3 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
13.3 40.0 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
10.7 32.2 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
10.2 143.5 GO:0006450 regulation of translational fidelity(GO:0006450)
10.2 30.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
9.3 27.9 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
8.5 59.6 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
8.3 83.1 GO:0006116 NADH oxidation(GO:0006116)
7.6 30.6 GO:0071331 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
7.2 35.8 GO:0007535 donor selection(GO:0007535)
7.1 28.3 GO:0098740 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
7.0 20.9 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
6.8 27.3 GO:0015886 heme transport(GO:0015886)
5.7 17.1 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
5.7 51.0 GO:0006814 sodium ion transport(GO:0006814)
5.1 35.9 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
4.7 14.2 GO:0046416 D-amino acid metabolic process(GO:0046416)
4.7 113.7 GO:0006414 translational elongation(GO:0006414)
4.7 18.9 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
4.6 13.7 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
4.5 13.4 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
4.0 15.9 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
3.9 19.3 GO:2000758 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
3.9 27.0 GO:0009098 leucine biosynthetic process(GO:0009098)
3.9 11.6 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
3.8 26.4 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
3.6 102.1 GO:0006096 glycolytic process(GO:0006096) nucleoside diphosphate phosphorylation(GO:0006165) ATP generation from ADP(GO:0006757)
3.5 14.0 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
3.3 13.4 GO:0015909 long-chain fatty acid transport(GO:0015909) fatty-acyl-CoA metabolic process(GO:0035337)
3.3 16.4 GO:0046417 chorismate metabolic process(GO:0046417)
3.3 9.8 GO:1901070 GMP biosynthetic process(GO:0006177) guanosine-containing compound biosynthetic process(GO:1901070)
3.2 9.7 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
3.1 9.3 GO:0044209 AMP salvage(GO:0044209)
3.1 15.4 GO:0035392 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
3.0 21.3 GO:0043457 regulation of cellular respiration(GO:0043457)
3.0 9.0 GO:0035952 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
2.9 5.9 GO:0046083 adenine metabolic process(GO:0046083)
2.9 28.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
2.8 13.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
2.8 8.3 GO:1902101 positive regulation of mitotic nuclear division(GO:0045840) positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101) positive regulation of ubiquitin protein ligase activity(GO:1904668)
2.7 2.7 GO:0046037 GMP metabolic process(GO:0046037)
2.7 10.8 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
2.7 48.2 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
2.7 10.6 GO:0042938 dipeptide transport(GO:0042938)
2.6 13.1 GO:0015780 nucleotide-sugar transport(GO:0015780)
2.6 7.7 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
2.5 2.5 GO:0010695 regulation of spindle pole body separation(GO:0010695)
2.5 9.9 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
2.4 7.3 GO:0071478 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
2.4 21.8 GO:0071966 cell wall chitin biosynthetic process(GO:0006038) fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
2.4 7.1 GO:1904666 regulation of ubiquitin protein ligase activity(GO:1904666)
2.3 11.7 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
2.2 11.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
2.2 30.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
2.0 10.1 GO:0051664 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
1.9 9.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
1.9 21.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
1.9 11.4 GO:0006458 'de novo' protein folding(GO:0006458)
1.9 9.4 GO:0006032 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
1.8 12.8 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
1.7 13.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
1.6 8.2 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
1.6 6.5 GO:0000296 spermine transport(GO:0000296)
1.6 11.0 GO:0034729 histone H3-K79 methylation(GO:0034729)
1.6 42.4 GO:0044108 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
1.5 20.9 GO:0031321 ascospore-type prospore assembly(GO:0031321)
1.5 1.5 GO:0070592 cell wall polysaccharide biosynthetic process(GO:0070592)
1.5 51.7 GO:0006487 protein N-linked glycosylation(GO:0006487)
1.5 5.9 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
1.4 7.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
1.4 12.9 GO:0031070 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
1.4 1.4 GO:0006901 vesicle coating(GO:0006901)
1.4 42.5 GO:0007096 regulation of exit from mitosis(GO:0007096)
1.4 5.7 GO:0042256 mature ribosome assembly(GO:0042256)
1.4 19.7 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
1.4 7.0 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
1.4 4.1 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
1.4 4.1 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133) regulation of cellular amine catabolic process(GO:0033241)
1.3 5.3 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
1.3 4.0 GO:0051238 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
1.3 5.2 GO:0006563 L-serine metabolic process(GO:0006563)
1.3 9.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
1.3 28.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
1.3 10.2 GO:0090522 vesicle tethering involved in exocytosis(GO:0090522)
1.2 2.5 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
1.2 7.3 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
1.2 4.7 GO:0009090 homoserine biosynthetic process(GO:0009090)
1.2 10.6 GO:0006797 polyphosphate metabolic process(GO:0006797)
1.2 15.1 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
1.1 20.7 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
1.1 5.7 GO:0007030 Golgi organization(GO:0007030)
1.1 3.2 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
1.1 13.9 GO:0006862 nucleotide transport(GO:0006862) cofactor transport(GO:0051181)
1.1 6.4 GO:0070941 eisosome assembly(GO:0070941)
1.1 3.2 GO:0006449 regulation of translational termination(GO:0006449)
1.0 5.2 GO:0007119 budding cell isotropic bud growth(GO:0007119)
1.0 11.4 GO:0046685 response to arsenic-containing substance(GO:0046685)
1.0 3.1 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.0 3.0 GO:1902707 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
1.0 14.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
1.0 11.9 GO:0009636 response to toxic substance(GO:0009636)
1.0 3.0 GO:0006624 vacuolar protein processing(GO:0006624)
1.0 7.8 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
1.0 23.8 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.9 2.7 GO:0044109 cellular alcohol catabolic process(GO:0044109) positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation(GO:0061412)
0.9 8.7 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.9 4.3 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.8 3.3 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.8 7.3 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.8 0.8 GO:0031555 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178) transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.8 3.2 GO:0006560 proline metabolic process(GO:0006560) proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.8 11.2 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.8 0.8 GO:0006567 threonine catabolic process(GO:0006567)
0.7 18.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.7 2.2 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
0.7 5.7 GO:0006903 vesicle targeting(GO:0006903) vesicle localization(GO:0051648) establishment of vesicle localization(GO:0051650)
0.7 11.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.7 4.3 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.7 4.2 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.7 4.9 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.7 4.6 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.6 4.4 GO:0006415 translational termination(GO:0006415)
0.6 70.9 GO:0006913 nucleocytoplasmic transport(GO:0006913)
0.6 2.3 GO:0019365 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.6 1.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.6 1.1 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.6 3.4 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.5 1.6 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.5 1.6 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.5 8.8 GO:0006334 nucleosome assembly(GO:0006334)
0.5 8.7 GO:0006378 mRNA polyadenylation(GO:0006378)
0.5 3.3 GO:0019722 calcium-mediated signaling(GO:0019722)
0.5 9.3 GO:0051647 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.5 16.2 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.5 11.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.5 10.0 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.4 2.7 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.4 1.8 GO:0051260 protein homooligomerization(GO:0051260)
0.4 14.1 GO:0006333 chromatin assembly or disassembly(GO:0006333)
0.4 4.8 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.4 3.5 GO:0006189 IMP biosynthetic process(GO:0006188) 'de novo' IMP biosynthetic process(GO:0006189) IMP metabolic process(GO:0046040)
0.4 2.2 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.4 7.5 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.4 0.8 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054) negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.4 1.2 GO:0006517 protein deglycosylation(GO:0006517)
0.4 1.2 GO:0000730 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.4 11.3 GO:0001302 replicative cell aging(GO:0001302)
0.4 5.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.4 1.6 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.4 1.9 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.4 3.0 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.4 0.7 GO:0097271 protein localization to bud neck(GO:0097271)
0.4 10.3 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.4 2.1 GO:0061572 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.3 4.3 GO:0007117 budding cell bud growth(GO:0007117)
0.3 1.0 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.3 6.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.3 2.5 GO:0000921 septin ring assembly(GO:0000921)
0.3 2.7 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.3 1.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.3 1.6 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.3 6.7 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.3 1.1 GO:0046655 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.3 3.6 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.2 1.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 15.0 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.2 4.6 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.2 1.8 GO:0010529 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.2 0.5 GO:0051693 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.2 1.5 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.2 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.2 10.4 GO:0051302 regulation of cell division(GO:0051302)
0.2 0.3 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.2 0.9 GO:0070058 tRNA gene clustering(GO:0070058)
0.2 0.6 GO:0006857 oligopeptide transport(GO:0006857)
0.1 0.6 GO:0007009 plasma membrane organization(GO:0007009)
0.1 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 2.5 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.1 1.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 0.5 GO:0031087 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 2.0 GO:0009267 cellular response to starvation(GO:0009267)
0.1 0.9 GO:0031120 tRNA pseudouridine synthesis(GO:0031119) snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.1 0.6 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.1 1.0 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.1 2.7 GO:0006413 translational initiation(GO:0006413)
0.1 0.7 GO:0009303 rRNA transcription(GO:0009303)
0.1 0.5 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.1 0.2 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.1 2.4 GO:0007015 actin filament organization(GO:0007015)
0.1 0.5 GO:0097502 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.1 0.3 GO:0000076 DNA replication checkpoint(GO:0000076)
0.1 0.4 GO:0032147 activation of protein kinase activity(GO:0032147)
0.1 0.6 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.1 0.5 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 0.4 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.1 0.8 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.2 GO:0018410 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.0 1.0 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.4 GO:0010833 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004) telomere maintenance via telomere lengthening(GO:0010833)
0.0 0.9 GO:0006400 tRNA modification(GO:0006400)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
31.2 1902.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
29.5 2480.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
19.9 59.6 GO:0032299 ribonuclease H2 complex(GO:0032299)
18.4 92.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
13.3 40.0 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
6.2 18.7 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
4.8 14.4 GO:0030869 RENT complex(GO:0030869)
4.2 59.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
4.2 33.3 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
3.9 11.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
3.0 18.2 GO:0034455 t-UTP complex(GO:0034455)
2.9 34.7 GO:0000788 nuclear nucleosome(GO:0000788)
2.9 11.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.7 16.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
2.7 10.7 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
2.6 7.8 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
2.5 15.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
2.5 7.5 GO:0071261 Ssh1 translocon complex(GO:0071261)
2.3 16.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
2.2 6.7 GO:0097344 Rix1 complex(GO:0097344)
2.2 15.2 GO:0031080 nuclear pore outer ring(GO:0031080)
2.1 8.3 GO:0033597 mitotic checkpoint complex(GO:0033597)
2.0 13.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
1.9 9.7 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.9 32.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.9 5.6 GO:0070545 PeBoW complex(GO:0070545)
1.8 14.1 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
1.8 5.3 GO:0070939 Dsl1p complex(GO:0070939)
1.8 5.3 GO:0030428 cell septum(GO:0030428)
1.7 13.8 GO:0005688 U6 snRNP(GO:0005688)
1.7 3.4 GO:0033553 rDNA heterochromatin(GO:0033553)
1.7 15.1 GO:0000137 Golgi cis cisterna(GO:0000137)
1.5 12.2 GO:0042597 periplasmic space(GO:0042597)
1.5 11.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
1.5 5.9 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
1.4 12.9 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
1.4 13.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
1.3 22.8 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
1.3 14.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
1.3 10.2 GO:0000145 exocyst(GO:0000145)
1.3 19.1 GO:0005940 septin ring(GO:0005940)
1.2 22.5 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
1.2 35.7 GO:0005844 polysome(GO:0005844)
1.2 53.6 GO:0044445 cytosolic part(GO:0044445)
1.2 4.7 GO:0000938 GARP complex(GO:0000938)
1.2 4.6 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
1.1 8.0 GO:0044615 nuclear pore nuclear basket(GO:0044615)
1.1 3.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
1.0 7.3 GO:0032432 actin filament bundle(GO:0032432)
1.0 4.8 GO:0031588 nuclear envelope lumen(GO:0005641) nucleotide-activated protein kinase complex(GO:0031588)
0.9 4.6 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.9 2.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.9 42.8 GO:0030659 vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659)
0.9 4.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.9 5.2 GO:0032126 eisosome(GO:0032126)
0.8 4.0 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.7 5.0 GO:0000346 transcription export complex(GO:0000346)
0.7 15.7 GO:0032040 small-subunit processome(GO:0032040)
0.7 10.0 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.7 4.0 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.7 23.8 GO:0005811 lipid particle(GO:0005811)
0.7 26.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.6 11.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.6 5.1 GO:0033101 cellular bud membrane(GO:0033101)
0.6 2.5 GO:0031518 CBF3 complex(GO:0031518)
0.6 96.9 GO:0005933 cellular bud(GO:0005933)
0.6 4.9 GO:0017119 Golgi transport complex(GO:0017119)
0.6 18.8 GO:0015935 small ribosomal subunit(GO:0015935)
0.6 1.2 GO:0000786 nucleosome(GO:0000786)
0.6 1.1 GO:0005871 kinesin complex(GO:0005871)
0.6 2.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.5 3.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.5 35.3 GO:0000139 Golgi membrane(GO:0000139)
0.5 1.6 GO:0005845 mRNA cap binding complex(GO:0005845)
0.5 3.0 GO:0070772 PAS complex(GO:0070772)
0.5 7.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 18.9 GO:0030479 actin cortical patch(GO:0030479) endocytic patch(GO:0061645)
0.4 1.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.4 14.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.4 3.6 GO:0098589 membrane region(GO:0098589)
0.4 2.5 GO:0072686 mitotic spindle(GO:0072686)
0.3 1.0 GO:0070390 transcription export complex 2(GO:0070390)
0.3 15.4 GO:0005815 microtubule organizing center(GO:0005815) spindle pole body(GO:0005816)
0.3 4.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.3 1.3 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.3 1.2 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.3 1.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 2.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541) endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.2 2.7 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.2 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 0.8 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.2 22.3 GO:0005730 nucleolus(GO:0005730)
0.2 0.9 GO:0044815 DNA packaging complex(GO:0044815)
0.2 1.8 GO:0000243 commitment complex(GO:0000243)
0.2 0.9 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.2 1.9 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.2 0.8 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.2 0.8 GO:0000922 spindle pole(GO:0000922)
0.2 1.6 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.2 10.4 GO:0005681 spliceosomal complex(GO:0005681)
0.1 0.6 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 0.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.5 GO:0031501 mannosyltransferase complex(GO:0031501)
0.1 0.3 GO:0070209 ASTRA complex(GO:0070209)
0.1 1.1 GO:0034708 methyltransferase complex(GO:0034708)
0.1 6.1 GO:0005794 Golgi apparatus(GO:0005794)
0.1 1.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.9 GO:0016586 RSC complex(GO:0016586)
0.1 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 4.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.1 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
20.8 4354.3 GO:0003735 structural constituent of ribosome(GO:0003735)
19.9 59.8 GO:0019003 GDP binding(GO:0019003)
14.9 59.6 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
10.1 60.7 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
9.9 29.7 GO:0072341 modified amino acid binding(GO:0072341)
9.7 29.0 GO:0070568 guanylyltransferase activity(GO:0070568)
9.0 26.9 GO:0003938 IMP dehydrogenase activity(GO:0003938)
8.1 48.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
7.4 37.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
7.0 21.0 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
7.0 20.9 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
6.8 27.3 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
5.2 15.5 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
5.0 24.9 GO:0008443 phosphofructokinase activity(GO:0008443)
4.5 17.8 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
4.5 57.9 GO:0003746 translation elongation factor activity(GO:0003746)
4.4 44.0 GO:0005216 ion channel activity(GO:0005216)
4.3 21.6 GO:0008536 Ran GTPase binding(GO:0008536)
4.3 21.6 GO:0070300 phosphatidic acid binding(GO:0070300)
4.2 59.5 GO:0001054 RNA polymerase I activity(GO:0001054)
4.1 16.6 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
4.0 15.9 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
3.9 11.8 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
3.9 11.6 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
3.9 15.5 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
3.9 11.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
3.8 11.4 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
3.8 15.1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
3.5 17.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
3.5 13.8 GO:0016832 aldehyde-lyase activity(GO:0016832)
3.3 13.4 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
3.3 16.3 GO:0004707 MAP kinase activity(GO:0004707)
3.1 18.9 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
2.9 17.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
2.9 11.6 GO:0016725 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.7 31.9 GO:0030276 clathrin binding(GO:0030276)
2.6 13.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
2.5 15.3 GO:0016408 C-acyltransferase activity(GO:0016408)
2.5 7.4 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
2.3 9.3 GO:0019206 nucleoside kinase activity(GO:0019206)
2.0 6.1 GO:0051010 microtubule plus-end binding(GO:0051010)
1.9 65.3 GO:0003678 DNA helicase activity(GO:0003678)
1.9 5.7 GO:0043023 ribosomal large subunit binding(GO:0043023)
1.9 5.7 GO:0016504 peptidase activator activity(GO:0016504)
1.9 11.2 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.9 7.5 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
1.8 5.3 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
1.8 3.5 GO:0099516 ion antiporter activity(GO:0099516)
1.8 3.5 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
1.7 16.9 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
1.7 16.9 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
1.7 6.7 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
1.6 6.5 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
1.6 6.4 GO:1901677 phosphate transmembrane transporter activity(GO:1901677)
1.6 12.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
1.6 32.8 GO:0019901 protein kinase binding(GO:0019901)
1.5 4.6 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
1.5 6.2 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.5 13.7 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
1.5 16.5 GO:0030295 protein kinase activator activity(GO:0030295)
1.5 11.9 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
1.4 12.5 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
1.4 13.8 GO:0001056 RNA polymerase III activity(GO:0001056)
1.3 9.4 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
1.3 15.7 GO:0005516 calmodulin binding(GO:0005516)
1.3 12.9 GO:0000171 ribonuclease MRP activity(GO:0000171) ribonuclease P activity(GO:0004526)
1.3 7.7 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
1.3 15.4 GO:0019843 rRNA binding(GO:0019843)
1.3 25.3 GO:0016836 hydro-lyase activity(GO:0016836)
1.2 25.3 GO:0051287 NAD binding(GO:0051287)
1.2 22.3 GO:0030515 snoRNA binding(GO:0030515)
1.2 73.1 GO:0003924 GTPase activity(GO:0003924)
1.0 3.1 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
1.0 4.0 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
1.0 4.0 GO:0008312 7S RNA binding(GO:0008312)
1.0 8.7 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.9 2.7 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.9 9.4 GO:0051015 actin filament binding(GO:0051015)
0.9 20.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.8 2.5 GO:0004100 chitin synthase activity(GO:0004100)
0.8 5.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.8 5.1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.8 6.7 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.8 24.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.8 11.1 GO:0001671 ATPase activator activity(GO:0001671)
0.8 5.5 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.8 3.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.7 2.9 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.7 13.2 GO:0016866 intramolecular transferase activity(GO:0016866)
0.7 18.7 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.7 10.0 GO:0070566 adenylyltransferase activity(GO:0070566)
0.7 5.0 GO:0019237 centromeric DNA binding(GO:0019237)
0.7 8.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.7 2.8 GO:0016841 ammonia-lyase activity(GO:0016841)
0.7 2.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.7 3.4 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.7 48.0 GO:0016791 phosphatase activity(GO:0016791)
0.6 4.4 GO:0019211 phosphatase activator activity(GO:0019211)
0.6 41.9 GO:0051082 unfolded protein binding(GO:0051082)
0.6 5.6 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.5 10.4 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.5 1.6 GO:0000339 RNA cap binding(GO:0000339)
0.5 10.0 GO:0003688 DNA replication origin binding(GO:0003688)
0.5 2.4 GO:0017022 myosin binding(GO:0017022)
0.5 1.9 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.5 19.7 GO:0005096 GTPase activator activity(GO:0005096)
0.4 2.2 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.4 1.6 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.4 2.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.4 4.6 GO:0005199 structural constituent of cell wall(GO:0005199)
0.4 5.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.4 2.3 GO:0019201 nucleotide kinase activity(GO:0019201)
0.4 13.4 GO:0042393 histone binding(GO:0042393)
0.4 2.1 GO:0030145 manganese ion binding(GO:0030145)
0.3 1.7 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.3 9.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.3 10.8 GO:0000030 mannosyltransferase activity(GO:0000030)
0.3 1.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 1.8 GO:0030695 GTPase regulator activity(GO:0030695)
0.3 3.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.3 14.4 GO:0008565 protein transporter activity(GO:0008565)
0.3 4.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.3 6.0 GO:0008170 N-methyltransferase activity(GO:0008170)
0.3 2.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.2 1.0 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.2 5.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 2.6 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.2 1.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.2 6.4 GO:0051540 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.2 55.1 GO:0003723 RNA binding(GO:0003723)
0.2 0.8 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.2 1.0 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.2 3.4 GO:0003774 motor activity(GO:0003774)
0.2 1.9 GO:0000182 rDNA binding(GO:0000182)
0.2 3.5 GO:0046983 protein dimerization activity(GO:0046983)
0.2 0.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 1.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.2 0.6 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.1 1.0 GO:0004312 fatty acid synthase activity(GO:0004312)
0.1 0.4 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.1 1.8 GO:0004659 prenyltransferase activity(GO:0004659)
0.1 1.6 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.1 0.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.5 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 1.1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.7 GO:0034061 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.1 3.0 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 2.4 GO:0000287 magnesium ion binding(GO:0000287)
0.1 0.8 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 0.8 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 0.3 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129)
0.1 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.2 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.4 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.0 0.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.1 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.0 0.7 GO:0043130 ubiquitin binding(GO:0043130)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 20.9 PID SHP2 PATHWAY SHP2 signaling
3.5 10.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
1.7 8.3 PID PLK1 PATHWAY PLK1 signaling events
1.4 5.4 PID E2F PATHWAY E2F transcription factor network
1.3 3.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.8 2.5 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.6 1.1 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
31.8 254.1 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
31.0 496.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
7.0 20.9 REACTOME INSULIN RECEPTOR SIGNALLING CASCADE Genes involved in Insulin receptor signalling cascade
5.5 16.5 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
5.4 21.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
4.3 12.8 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
4.2 8.3 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
3.1 12.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
3.0 9.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
2.6 7.8 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
1.9 15.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
1.3 1.3 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
0.8 2.5 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.6 2.3 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.5 1.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.5 3.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.4 4.6 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.3 1.9 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 1.6 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.2 2.6 REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.1 0.3 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology