Results for RAP1
Z-value: 8.56
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Transcription factors associated with RAP1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RAP1
|
S000005160 | Essential DNA-binding transcription regulator that binds at many loci |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YJR094W-A Show fit | 98.78 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein |
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| YNL338W Show fit | 82.56 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV |
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| YER117W Show fit | 70.57 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins |
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| YFR055W Show fit | 69.31 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YLR167W Show fit | 65.79 |
Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B |
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| YPL250W-A Show fit | 65.11 |
Identified by fungal homology and RT-PCR |
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| YOR293W Show fit | 64.33 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10 |
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| YHL015W Show fit | 63.89 |
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins |
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| YMR142C Show fit | 63.24 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein |
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| YPL079W Show fit | 63.12 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of RAP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 25.5 | 3497.0 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 27.1 | 434.4 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 39.7 | 158.6 | GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461) |
| 36.8 | 147.1 | GO:0046898 | response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898) |
| 10.2 | 143.5 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 4.7 | 113.7 | GO:0006414 | translational elongation(GO:0006414) |
| 3.6 | 102.1 | GO:0006096 | glycolytic process(GO:0006096) nucleoside diphosphate phosphorylation(GO:0006165) ATP generation from ADP(GO:0006757) |
| 8.3 | 83.1 | GO:0006116 | NADH oxidation(GO:0006116) |
| 0.6 | 70.9 | GO:0006913 | nucleocytoplasmic transport(GO:0006913) |
| 23.1 | 69.3 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 29.5 | 2480.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 31.2 | 1902.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.6 | 96.9 | GO:0005933 | cellular bud(GO:0005933) |
| 18.4 | 92.2 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 19.9 | 59.6 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 4.2 | 59.5 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 1.2 | 53.6 | GO:0044445 | cytosolic part(GO:0044445) |
| 0.9 | 42.8 | GO:0030659 | vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659) |
| 13.3 | 40.0 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 1.2 | 35.7 | GO:0005844 | polysome(GO:0005844) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.8 | 4354.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.2 | 73.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.9 | 65.3 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 10.1 | 60.7 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 19.9 | 59.8 | GO:0019003 | GDP binding(GO:0019003) |
| 14.9 | 59.6 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 4.2 | 59.5 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 4.5 | 57.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.2 | 55.1 | GO:0003723 | RNA binding(GO:0003723) |
| 8.1 | 48.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 20.9 | PID SHP2 PATHWAY | SHP2 signaling |
| 3.5 | 10.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 1.7 | 8.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.4 | 5.4 | PID E2F PATHWAY | E2F transcription factor network |
| 1.3 | 3.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.8 | 2.5 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.6 | 1.1 | PID FGF PATHWAY | FGF signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 31.0 | 496.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 31.8 | 254.1 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 5.4 | 21.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 7.0 | 20.9 | REACTOME INSULIN RECEPTOR SIGNALLING CASCADE | Genes involved in Insulin receptor signalling cascade |
| 5.5 | 16.5 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 1.9 | 15.3 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 4.3 | 12.8 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 3.1 | 12.3 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 3.0 | 9.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 4.2 | 8.3 | REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |