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Results for RDR1

Z-value: 0.80

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Transcription factors associated with RDR1

Gene Symbol Gene ID Gene Info
RDR1
S000005907 Transcriptional repressor involved in regulating multidrug resistance

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RDR1YOR380W-0.357.8e-02Click!

Activity profile of RDR1 motif

Sorted Z-values of RDR1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YDR345C 3.97
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YHR092C 3.87
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YGR108W 3.86
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YKL096W-A 3.81
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YJR105W 2.68
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YGL055W 2.67
OLE1
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YCL064C 2.64
CHA1
Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YLR328W 2.45
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YFR055W 2.29
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YLR110C 2.27
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YOL086C 2.27
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YHR136C 2.21
SPL2
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YIL162W 1.97
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YOL085C 1.91 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YFR056C 1.88 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YGR107W 1.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR106C 1.70
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YKL182W 1.69
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YDR033W 1.68
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YHR216W 1.67
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YEL027W 1.64
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YHR071C-A 1.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W
YHR143W 1.52
DSE2
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YDR133C 1.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YHR137W 1.39
ARO9
Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YDR002W 1.39
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YOR051C 1.36 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YHR072W 1.32
ERG7
Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
YCL063W 1.31
VAC17
Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YGR249W 1.29
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YNL160W 1.29
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YGR254W 1.26
ENO1
Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YKL219W 1.21
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YLR348C 1.20
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YKL051W 1.19
SFK1
Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YOL154W 1.17
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YPL256C 1.16
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YOR101W 1.15
RAS1
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YOR317W 1.14
FAA1
Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YER131W 1.14
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YJR094W-A 1.13
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YLR349W 1.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YPR113W 1.11
PIS1
Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
YHR174W 1.11
ENO2
Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
YPR157W 1.11 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YEL066W 1.10
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YJL153C 1.09
INO1
Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YLR350W 1.09
ORM2
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YNR001W-A 1.07 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YLR154C 1.07
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YCR102W-A 1.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR028W 1.05
YOP1
Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells
YNR016C 1.02
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YGR052W 1.02
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YOL101C 1.02
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YKR038C 1.01
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YJL216C 0.99 Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YDR044W 0.97
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YOR049C 0.96
RSB1
Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YGR036C 0.95
CAX4
Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YMR122C 0.95 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL124C 0.95
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YGL157W 0.94 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YNL028W 0.93 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR146C 0.93 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR122W-A 0.92 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum
YLR212C 0.92
TUB4
Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
YPR074C 0.92
TKL1
Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YGR280C 0.92
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YBR053C 0.91 Putative protein of unknown function; induced by cell wall perturbation
YOR095C 0.91
RKI1
Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
YMR194C-A 0.91 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR249C 0.90
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YDR010C 0.90 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL014W 0.89 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YMR305C 0.88
SCW10
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YEL067C 0.87 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL011C 0.85
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YIL051C 0.84
MMF1
Mitochondrial protein involved in maintenance of the mitochondrial genome
YLL028W 0.84
TPO1
Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
YLR109W 0.84
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YLR258W 0.82
GSY2
Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YJL133W 0.82
MRS3
Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs4p; functions under low-iron conditions; may transport other cations in addition to iron
YMR082C 0.81 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR083W 0.80
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YDR304C 0.79
CPR5
Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
YDR276C 0.79
PMP3
Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YBR293W 0.77
VBA2
Permease of basic amino acids in the vacuolar membrane
YMR205C 0.76
PFK2
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YIL076W 0.76
SEC28
Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YER146W 0.74
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YOL020W 0.73
TAT2
High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance
YKL218C 0.73
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YGR131W 0.72 Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YJR016C 0.71
ILV3
Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
YPL274W 0.71
SAM3
High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YOL039W 0.69
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YDR072C 0.69
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YLR154W-B 0.68 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGR138C 0.67
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YNL035C 0.67 Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
YJL158C 0.66
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YPL265W 0.66
DIP5
Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YOR063W 0.66
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YNL066W 0.66
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YCR102C 0.65 Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene
YDR098C 0.65
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YPL273W 0.65
SAM4
S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YKR066C 0.63
CCP1
Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YIL148W 0.63
RPL40A
Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YER124C 0.63
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YCR024C-B 0.63 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YOR376W-A 0.62 Putative protein of unknown function; identified by fungal homology and RT-PCR
YGL179C 0.62
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YIL169C 0.61 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YEL001C 0.61
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YMR123W 0.60
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YIL118W 0.60
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YDR129C 0.60
SAC6
Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
YMR290C 0.59
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YGR157W 0.59
CHO2
Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YDL018C 0.59
ERP3
Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YCR104W 0.59
PAU3
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDL186W 0.59 Putative protein of unknown function; YDL186W is not an essential gene
YDR032C 0.59
PST2
Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR140W 0.59 Putative integral membrane protein of unknown function
YLR256W 0.58
HAP1
Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
YNL055C 0.58
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YMR001C-A 0.58 Putative protein of unknown function
YNL090W 0.58
RHO2
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YLR301W 0.56 Protein of unknown function that interacts with Sec72p
YNL029C 0.56
KTR5
Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YMR032W 0.56
HOF1
Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YKR088C 0.55
TVP38
Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YPL131W 0.55
RPL5
Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly
YNL239W 0.55
LAP3
Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
YNL336W 0.55
COS1
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGR177C 0.54
ATF2
Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing
YBR221C 0.54
PDB1
E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
YPR149W 0.54
NCE102
Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YBR052C 0.53
RFS1
Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOR122C 0.53
PFY1
Profilin, actin- and phosphatidylinositol 4,5-bisphosphate-binding protein, involved in cytoskeleton organization, required for normal timing of actin polymerization in response to thermal stress; localizes to plasma membrane and cytosol
YLR112W 0.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR041W 0.52
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YDR101C 0.52
ARX1
Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YCR018C 0.52
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YBR177C 0.52
EHT1
Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YHR049W 0.52
FSH1
Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh2p and Fsh3p
YER031C 0.52
YPT31
GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YIL011W 0.51
TIR3
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YLR113W 0.51
HOG1
Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
YFR047C 0.51
BNA6
Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YEL017W 0.51
GTT3
Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YNL024C 0.51 Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene
YNL148C 0.51
ALF1
Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
YDR086C 0.51
SSS1
Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YKR075C 0.51 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YCR022C 0.50 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YEL029C 0.50
BUD16
Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YOR273C 0.50
TPO4
Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YPR170W-B 0.50 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YDR225W 0.50
HTA1
One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YOR021C 0.49 Putative protein of unknown function; YOR021C is not an essential gene
YHR124W 0.49
NDT80
Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
YHR177W 0.49 Putative protein of unknown function
YDL022C-A 0.49 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YER055C 0.49
HIS1
ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YCR006C 0.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR288C 0.48
MPD1
Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
YDR531W 0.48 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YNL338W 0.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YGR050C 0.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR399W 0.47
HPT1
Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YKL141W 0.47
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YLR314C 0.47
CDC3
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YIR027C 0.47
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YLR257W 0.47 Putative protein of unknown function
YER177W 0.47
BMH1
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YGL209W 0.47
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YNR003C 0.47
RPC34
RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YOR029W 0.47 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YKL008C 0.46
LAC1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YIL009C-A 0.46
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YMR290W-A 0.46 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YGR234W 0.45
YHB1
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YGR055W 0.45
MUP1
High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
YDR037W 0.45
KRS1
Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YDR040C 0.45
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YFL028C 0.45
CAF16
Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; putative ABC ATPase; interacts with Ssn2p, Ssn3p, and Ssn8p
YGR250C 0.45 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL174C 0.45
TPO5
Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
YGR139W 0.45 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML043C 0.44
RRN11
Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YMR006C 0.44
PLB2
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YGR242W 0.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YGR025W 0.44 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL015W-A 0.44 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR054C 0.44 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR369C 0.43
RPS12
Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YML132W 0.43
COS3
Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Network of associatons between targets according to the STRING database.

First level regulatory network of RDR1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0006567 threonine catabolic process(GO:0006567)
0.9 2.7 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.9 2.7 GO:0044209 AMP salvage(GO:0044209)
0.8 2.4 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.6 2.5 GO:0098740 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.6 4.3 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.6 2.4 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.6 3.0 GO:0006177 GMP biosynthetic process(GO:0006177)
0.6 2.3 GO:0000296 spermine transport(GO:0000296)
0.5 1.4 GO:0097052 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.4 1.3 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.4 3.6 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
0.4 1.1 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.4 1.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.4 0.7 GO:0015848 spermidine transport(GO:0015848)
0.3 0.6 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.3 1.1 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.3 0.3 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.3 3.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.3 2.3 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.2 1.2 GO:0015908 fatty acid transport(GO:0015908)
0.2 0.9 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.2 1.3 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.2 1.0 GO:0006021 inositol biosynthetic process(GO:0006021)
0.2 3.1 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.2 0.8 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.2 1.4 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.2 0.6 GO:0000101 sulfur amino acid transport(GO:0000101)
0.2 1.5 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.2 1.3 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.2 2.1 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.2 0.6 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.2 0.7 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
0.2 0.5 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.2 4.6 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.2 0.4 GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.2 0.9 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.2 0.5 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.2 0.5 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.2 4.0 GO:0006885 regulation of pH(GO:0006885)
0.2 0.7 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 0.7 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.2 0.6 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.2 0.2 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.2 0.5 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2 0.3 GO:0045338 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.2 1.6 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.2 0.5 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.2 0.3 GO:0034764 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.1 0.4 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.1 2.3 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.1 1.1 GO:0006901 vesicle coating(GO:0006901)
0.1 0.7 GO:0044070 regulation of anion transport(GO:0044070)
0.1 1.0 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.1 0.1 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 0.4 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.1 0.8 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 3.1 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.1 1.3 GO:0006817 phosphate ion transport(GO:0006817)
0.1 2.6 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.1 0.2 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.1 1.0 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.2 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.1 0.4 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 0.5 GO:0070941 eisosome assembly(GO:0070941)
0.1 0.1 GO:0019358 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.1 1.1 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 0.3 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.1 0.6 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.1 0.3 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.3 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.1 0.3 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.1 1.2 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.1 0.5 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.5 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 1.3 GO:0000011 vacuole inheritance(GO:0000011)
0.1 0.2 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 2.6 GO:0044107 ergosterol metabolic process(GO:0008204) phytosteroid metabolic process(GO:0016128) cellular alcohol metabolic process(GO:0044107)
0.1 0.9 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.3 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.9 GO:0015802 basic amino acid transport(GO:0015802)
0.1 0.2 GO:0006595 polyamine metabolic process(GO:0006595)
0.1 0.7 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 1.4 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.3 GO:0030817 regulation of cyclic nucleotide metabolic process(GO:0030799) regulation of cyclic nucleotide biosynthetic process(GO:0030802) regulation of nucleotide biosynthetic process(GO:0030808) regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of purine nucleotide biosynthetic process(GO:1900371)
0.1 0.8 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.5 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 0.3 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 1.5 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.1 0.6 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 2.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.2 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 0.2 GO:0060988 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 1.1 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.1 0.2 GO:0043484 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
0.1 0.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.4 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.4 GO:0031506 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.1 9.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.3 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.6 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.7 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 1.2 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.5 GO:0015940 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.1 1.3 GO:0033673 negative regulation of kinase activity(GO:0033673)
0.1 0.2 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.8 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656) ethanolamine-containing compound metabolic process(GO:0042439) phosphatidylcholine metabolic process(GO:0046470)
0.1 0.3 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 0.3 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 0.6 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 0.7 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.2 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.1 0.2 GO:0015883 FAD transport(GO:0015883)
0.1 0.4 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.1 0.2 GO:0017157 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.1 0.5 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.0 1.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.3 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.0 0.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.8 GO:0006448 regulation of translational elongation(GO:0006448)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.0 0.1 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.0 0.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 1.5 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.0 GO:0035953 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.0 0.1 GO:0006311 meiotic gene conversion(GO:0006311)
0.0 0.8 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.2 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.0 0.1 GO:0034517 endoplasmic reticulum membrane fusion(GO:0016320) ribophagy(GO:0034517)
0.0 0.2 GO:0046174 polyol catabolic process(GO:0046174)
0.0 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.2 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 1.5 GO:0007015 actin filament organization(GO:0007015)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 1.2 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 0.4 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.7 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.2 GO:0030030 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
0.0 0.1 GO:0035376 sterol import(GO:0035376)
0.0 0.1 GO:0035384 acetyl-CoA biosynthetic process(GO:0006085) thioester biosynthetic process(GO:0035384) acyl-CoA biosynthetic process(GO:0071616)
0.0 1.1 GO:0006865 amino acid transport(GO:0006865)
0.0 0.5 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.9 GO:0033750 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
0.0 0.1 GO:0019346 transsulfuration(GO:0019346)
0.0 0.8 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.1 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.0 0.4 GO:0006826 iron ion transport(GO:0006826)
0.0 0.6 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.4 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0 0.1 GO:0006458 'de novo' protein folding(GO:0006458)
0.0 0.1 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.2 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.0 0.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0002376 immune effector process(GO:0002252) immune system process(GO:0002376) response to virus(GO:0009615) response to external biotic stimulus(GO:0043207) defense response to virus(GO:0051607) response to other organism(GO:0051707) defense response to other organism(GO:0098542)
0.0 0.4 GO:0072599 establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0 0.1 GO:0008272 sulfate transport(GO:0008272)
0.0 0.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.2 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.2 GO:0060261 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.0 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.1 GO:0006090 pyruvate metabolic process(GO:0006090)
0.0 0.4 GO:0006278 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004) telomere maintenance via telomere lengthening(GO:0010833)
0.0 0.1 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.3 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.2 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.1 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.3 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.0 0.1 GO:0001510 RNA methylation(GO:0001510)
0.0 0.1 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.2 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.2 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.1 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.0 0.1 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.0 3.4 GO:0006364 rRNA processing(GO:0006364)
0.0 0.0 GO:0031292 gene conversion at mating-type locus, DNA double-strand break processing(GO:0031292)
0.0 0.2 GO:0006415 translational termination(GO:0006415)
0.0 0.1 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.0 0.2 GO:0006206 pyrimidine nucleobase metabolic process(GO:0006206)
0.0 0.0 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.1 GO:0000431 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.0 0.0 GO:0015856 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.0 0.2 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.0 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.0 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.0 0.0 GO:0045833 negative regulation of lipid metabolic process(GO:0045833)
0.0 0.2 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.0 0.0 GO:1901070 guanosine-containing compound biosynthetic process(GO:1901070)
0.0 0.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.0 GO:0016094 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.0 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.0 0.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 1.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 0.9 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.3 4.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 0.7 GO:0046930 pore complex(GO:0046930)
0.2 1.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.2 1.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.2 1.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 1.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.2 0.5 GO:0071261 Sec61 translocon complex(GO:0005784) Ssh1 translocon complex(GO:0071261)
0.1 1.2 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.6 GO:0000144 cellular bud neck septin ring(GO:0000144)
0.1 0.6 GO:0032160 septin filament array(GO:0032160)
0.1 3.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 6.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 5.1 GO:0005811 lipid particle(GO:0005811)
0.1 10.0 GO:0005576 extracellular region(GO:0005576)
0.1 0.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.0 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.5 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.4 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.1 0.7 GO:0032432 actin filament bundle(GO:0032432)
0.1 8.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.3 GO:0034457 Mpp10 complex(GO:0034457)
0.1 1.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.5 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 5.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.3 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.1 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 1.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.6 GO:0072686 mitotic spindle(GO:0072686)
0.1 1.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.5 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.3 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 0.2 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.1 0.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 0.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.1 GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.1 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.4 GO:0005775 vacuolar lumen(GO:0005775)
0.1 0.9 GO:0000786 nucleosome(GO:0000786)
0.1 0.2 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.2 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.1 1.0 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 1.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.1 GO:0044284 mitochondrial crista junction(GO:0044284)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 2.4 GO:0044445 cytosolic part(GO:0044445)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 11.9 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.2 GO:0034518 RNA cap binding complex(GO:0034518)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.1 GO:0097255 ASTRA complex(GO:0070209) R2TP complex(GO:0097255)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 1.6 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.2 GO:0034967 Set3 complex(GO:0034967)
0.0 0.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.1 GO:0034456 UTP-C complex(GO:0034456)
0.0 0.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.3 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120) RNA polymerase I upstream activating factor complex(GO:0000500)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 5.0 GO:0005886 plasma membrane(GO:0005886)
0.0 0.1 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.0 0.1 GO:0032045 eukaryotic translation initiation factor 2B complex(GO:0005851) guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.0 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.6 GO:0015934 large ribosomal subunit(GO:0015934)
0.0 0.1 GO:0016459 myosin complex(GO:0016459)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 1.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.1 GO:0034455 t-UTP complex(GO:0034455)
0.0 0.0 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.3 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.9 3.7 GO:0016841 ammonia-lyase activity(GO:0016841)
0.8 2.5 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.8 2.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.7 2.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.7 2.1 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.7 2.7 GO:0019206 nucleoside kinase activity(GO:0019206)
0.6 3.6 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.6 2.3 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.4 1.7 GO:0016417 S-acyltransferase activity(GO:0016417)
0.4 4.8 GO:0005199 structural constituent of cell wall(GO:0005199)
0.4 1.6 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.4 2.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.4 1.1 GO:0016872 intramolecular lyase activity(GO:0016872)
0.4 0.7 GO:0015606 spermidine transmembrane transporter activity(GO:0015606)
0.3 1.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 1.6 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.3 0.9 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.3 1.5 GO:0008443 phosphofructokinase activity(GO:0008443)
0.3 1.5 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.3 2.8 GO:0005216 ion channel activity(GO:0005216)
0.3 1.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.3 0.8 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.3 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.3 2.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 1.5 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.2 0.7 GO:0070568 guanylyltransferase activity(GO:0070568)
0.2 1.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.2 0.9 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.2 0.9 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 1.1 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.2 0.8 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.2 0.8 GO:0008172 S-methyltransferase activity(GO:0008172)
0.2 0.5 GO:0008097 5S rRNA binding(GO:0008097)
0.2 0.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 3.4 GO:0015926 glucosidase activity(GO:0015926)
0.2 4.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 2.5 GO:0070566 adenylyltransferase activity(GO:0070566)
0.2 1.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 1.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.2 0.5 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 1.4 GO:0010181 FMN binding(GO:0010181)
0.2 0.5 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.1 0.4 GO:0001187 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
0.1 1.6 GO:0043495 protein anchor(GO:0043495)
0.1 0.7 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.6 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 0.4 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 0.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.1 GO:0015645 fatty acid ligase activity(GO:0015645)
0.1 0.6 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.8 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 0.1 GO:0019210 kinase inhibitor activity(GO:0019210)
0.1 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.9 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.7 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 1.0 GO:0031386 protein tag(GO:0031386)
0.1 0.5 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.3 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 0.5 GO:0008312 7S RNA binding(GO:0008312)
0.1 0.4 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.4 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.1 0.3 GO:0004629 phospholipase C activity(GO:0004629)
0.1 0.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.6 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.1 0.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 2.0 GO:0016866 intramolecular transferase activity(GO:0016866)
0.1 0.3 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 1.4 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.1 1.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.2 GO:0048038 quinone binding(GO:0048038)
0.1 0.2 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.1 0.4 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 0.2 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.1 0.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 0.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.2 GO:0009922 fatty acid elongase activity(GO:0009922)
0.1 0.4 GO:0016853 isomerase activity(GO:0016853)
0.1 1.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.1 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.1 0.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.5 GO:0016860 intramolecular oxidoreductase activity(GO:0016860)
0.1 0.2 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.1 0.1 GO:0015248 sterol transporter activity(GO:0015248)
0.1 4.6 GO:0003924 GTPase activity(GO:0003924)
0.1 0.3 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.2 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.1 0.7 GO:0005319 lipid transporter activity(GO:0005319)
0.1 0.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 0.5 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 13.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.2 GO:0000339 RNA cap binding(GO:0000339)
0.1 0.6 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.1 0.5 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.1 0.2 GO:0004497 monooxygenase activity(GO:0004497)
0.1 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 0.7 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 0.2 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.3 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.1 0.7 GO:0051015 actin filament binding(GO:0051015)
0.1 0.2 GO:0097617 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.1 0.2 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.1 1.8 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 0.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.5 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.1 0.2 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.2 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.0 0.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.1 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.0 0.2 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 1.2 GO:0015631 tubulin binding(GO:0015631)
0.0 0.1 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163)
0.0 0.3 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.0 0.1 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.1 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.0 0.8 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.5 GO:0000049 tRNA binding(GO:0000049)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.1 GO:0019203 carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.0 0.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.0 0.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.5 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.1 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.2 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.0 0.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.1 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.7 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.5 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.1 GO:0008252 nucleotidase activity(GO:0008252)
0.0 0.8 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.0 0.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0016300 double-stranded DNA exodeoxyribonuclease activity(GO:0008309) tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.1 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296) single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 0.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.0 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0019001 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.0 0.0 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.0 0.1 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.1 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.0 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.0 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 0.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 0.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.0 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.1 PID SHP2 PATHWAY SHP2 signaling
0.0 0.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 0.4 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.2 0.5 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.2 1.2 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.2 1.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 0.3 REACTOME SIGNALING BY INSULIN RECEPTOR Genes involved in Signaling by Insulin receptor
0.1 2.0 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
0.1 0.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 0.9 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 0.3 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.1 0.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.1 REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION Genes involved in Post-translational protein modification
0.0 0.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.1 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.0 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.0 0.1 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 0.1 REACTOME TRANSLATION Genes involved in Translation