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Results for RFX1

Z-value: 0.80

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Transcription factors associated with RFX1

Gene Symbol Gene ID Gene Info
RFX1
S000004166 Major transcriptional repressor of DNA-damage-regulated genes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX1YLR176C-0.832.0e-07Click!

Activity profile of RFX1 motif

Sorted Z-values of RFX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 8.44
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 7.25 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YDR044W 4.62
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YHR141C 3.65
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YNR001W-A 3.41 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YGR108W 3.29
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YDL085C-A 3.12 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOR063W 3.04
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YOR315W 3.01
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YOL086C 2.90
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YGL097W 2.80
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YDR345C 2.78
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YNR067C 2.70
DSE4
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YBR210W 2.66
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YIL069C 2.64
RPS24B
Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YER137C 2.43 Putative protein of unknown function
YHR136C 2.40
SPL2
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YIL029C 2.35 Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YLR154C 2.34
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YJR063W 2.33
RPA12
RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
YER124C 2.29
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YJL136C 2.23
RPS21B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YGR180C 2.16
RNR4
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YDR279W 2.15
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YMR106C 2.13
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YGL031C 2.12
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YER043C 2.03
SAH1
S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YNL030W 2.00
HHF2
One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YML052W 1.98
SUR7
Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YGL030W 1.92
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YIR021W 1.90
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YHL028W 1.80
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YFR054C 1.79 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR154W-B 1.74 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-A 1.74 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR328W 1.74
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YIL114C 1.73
POR2
Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability
YMR119W 1.72
ASI1
Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YKR075C 1.69 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YKL120W 1.69
OAC1
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YER070W 1.68
RNR1
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YER011W 1.66
TIR1
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YML026C 1.63
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YKR094C 1.62
RPL40B
Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YGR155W 1.58
CYS4
Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YMR177W 1.56
MMT1
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YMR011W 1.51
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YKR038C 1.51
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YDL007W 1.46
RPT2
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YIL118W 1.46
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YMR006C 1.45
PLB2
Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YOR234C 1.44
RPL33B
Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YLR286C 1.43
CTS1
Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YPR170W-B 1.39 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YOR280C 1.37
FSH3
Serine hydrolase; sequence is similar to Fsh1p and Fsh2p
YBR158W 1.37
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YJL200C 1.37
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YGR040W 1.36
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YHR201C 1.35
PPX1
Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YDR112W 1.35
IRC2
Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
YGL039W 1.33 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YDR033W 1.33
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YDL229W 1.33
SSB1
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p
YGR181W 1.33
TIM13
Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YKL096W-A 1.32
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YOR047C 1.32
STD1
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YDL148C 1.30
NOP14
Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
YPL177C 1.26
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YDR072C 1.25
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YJL029C 1.24
VPS53
Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
YDL189W 1.23
RBS1
Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
YER107W-A 1.22 Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
YBL057C 1.22
PTH2
One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth
YPL142C 1.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
YOL155C 1.18
HPF1
Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YOR314W 1.18 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR170W-A 1.17 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YMR083W 1.17
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YGR090W 1.16
UTP22
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YOL085C 1.16 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YDR417C 1.16 Hypothetical protein
YHL015W 1.15
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YER107C 1.14
GLE2
Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
YJR094W-A 1.13
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YHR010W 1.12
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YOR313C 1.12
SPS4
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YGR052W 1.10
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YLR449W 1.09
FPR4
Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YBL028C 1.09 Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YGL034C 1.09 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL027W 1.09
RPL19B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YNL111C 1.08
CYB5
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YBR126W-A 1.08 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YDR111C 1.08
ALT2
Putative alanine transaminase (glutamic pyruvic transaminase)
YHR137W 1.06
ARO9
Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YDR534C 1.05
FIT1
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YJL198W 1.05
PHO90
Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YHR094C 1.05
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YGL012W 1.03
ERG4
C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YIL078W 1.03
THS1
Threonyl-tRNA synthetase, essential cytoplasmic protein
YKL153W 1.02 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YNL289W 1.02
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YLL034C 1.01
RIX7
Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
YDR060W 1.00
MAK21
Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YMR143W 1.00
RPS16A
Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YCR016W 0.99 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene
YGL040C 0.99
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YGR208W 0.99
SER2
Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
YNL031C 0.97
HHT2
One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YPR170C 0.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YLR025W 0.94
SNF7
One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
YIL009W 0.94
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YMR142C 0.94
RPL13B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YGR050C 0.93 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR078W 0.93
ECM33
GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
YHR170W 0.92
NMD3
Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YDR418W 0.92
RPL12B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YOL127W 0.92
RPL25
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YBR209W 0.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YIL009C-A 0.89
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YBR121C 0.89
GRS1
Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
YBL056W 0.88
PTC3
Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation
YKL219W 0.88
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGL080W 0.88
FMP37
Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL218C 0.87
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YDL236W 0.86
PHO13
Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein
YHR142W 0.85
CHS7
Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
YOR087W 0.84
YVC1
Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
YHR183W 0.84
GND1
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YNL016W 0.82
PUB1
Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
YBR112C 0.81
CYC8
General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YKL110C 0.81
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YGR179C 0.80
OKP1
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YDR215C 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
YGR164W 0.80 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR182C-A 0.80 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR199W 0.78
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YBR202W 0.78
MCM7
Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YGR106C 0.78
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YHR070C-A 0.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W
YJR145C 0.78
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YML053C 0.76 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YML053C is not an essential gene
YCR072C 0.75
RSA4
WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
YEL020C-B 0.75 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YGR214W 0.74
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YEL056W 0.72
HAT2
Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YOR269W 0.72
PAC1
Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1
YBR126C 0.71
TPS1
Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YML119W 0.71 Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YMR205C 0.71
PFK2
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YDL211C 0.71 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YER131W 0.69
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YOR164C 0.69 Protein of unknown function; highly conserved across species and homologous to human gene C7orf20; interacts with Mdy2p
YBR113W 0.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YDR047W 0.68
HEM12
Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YGR051C 0.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YNR013C 0.66
PHO91
Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YBR032W 0.66 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YDR535C 0.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YDR278C 0.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR218W 0.65
CRM1
Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus
YAL033W 0.65
POP5
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YDR410C 0.65
STE14
Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane
YGL225W 0.65
VRG4
Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YOL103W 0.64
ITR2
Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YNL043C 0.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YER012W 0.62
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YLR400W 0.61 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR157W 0.61 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YLR287C-A 0.61
RPS30A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein
YDL241W 0.61 Putative protein of unknown function; YDL241W is not an essential gene
YLR154W-C 0.61
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YDR133C 0.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YMR263W 0.60
SAP30
Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
YDR188W 0.60
CCT6
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
YIR033W 0.59
MGA2
ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YGR122W 0.59 Putative protein of unknown function; deletion mutants do not properly process Rim101p and have decreased resistance to rapamycin; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YJL028W 0.59 Protein of unknown function; may interact with ribosomes, based on co-purification experiments
YGR234W 0.58
YHB1
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YGR195W 0.58
SKI6
3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YDR073W 0.58
SNF11
Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YER003C 0.57
PMI40
Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YPR171W 0.57
BSP1
Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
YIL015W 0.57
BAR1
Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YAR002C-A 0.57
ERP1
Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YMR112C 0.56
MED11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
YLR321C 0.56
SFH1
Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
YGR187C 0.56
HGH1
Nonessential protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)
YMR099C 0.56 Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
YPR146C 0.56 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR187C 0.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
YMR113W 0.55
FOL3
Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
YHR181W 0.54
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YBL083C 0.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3
YOR086C 0.54
TCB1
Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact
YGR107W 0.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL028W 0.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR008C-A 0.52 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YKL179C 0.52
COY1
Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
YMR290W-A 0.52 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.4 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.9 3.6 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.9 2.7 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.8 2.5 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.8 5.5 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.7 3.0 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
0.7 2.1 GO:2000879 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.6 4.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.6 1.7 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.5 3.4 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.5 2.3 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.5 1.4 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.4 1.3 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.4 0.9 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.4 3.9 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
0.4 2.1 GO:0007535 donor selection(GO:0007535)
0.4 1.6 GO:0019346 transsulfuration(GO:0019346)
0.4 3.9 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.4 1.5 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.4 1.1 GO:0031057 negative regulation of histone modification(GO:0031057)
0.4 1.8 GO:0044070 regulation of anion transport(GO:0044070)
0.4 1.1 GO:0097053 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.3 5.6 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.3 0.9 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.3 0.9 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.3 1.5 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.3 0.6 GO:2000531 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter(GO:0100070) regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter(GO:2000531)
0.3 0.9 GO:0006850 mitochondrial pyruvate transport(GO:0006850)
0.3 2.0 GO:0043171 peptide catabolic process(GO:0043171)
0.3 0.9 GO:0048024 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
0.3 0.6 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.3 0.8 GO:0010793 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.3 1.9 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.3 1.3 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.3 0.5 GO:0071902 positive regulation of protein serine/threonine kinase activity(GO:0071902)
0.3 1.3 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.3 1.3 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.2 0.5 GO:0090088 regulation of peptide transport(GO:0090087) regulation of oligopeptide transport(GO:0090088) regulation of dipeptide transport(GO:0090089)
0.2 1.9 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.2 7.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 2.9 GO:0007120 axial cellular bud site selection(GO:0007120)
0.2 1.1 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.2 0.8 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.2 1.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 1.0 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.2 1.7 GO:0006814 sodium ion transport(GO:0006814)
0.2 1.8 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.2 1.5 GO:0009395 phospholipid catabolic process(GO:0009395)
0.2 0.5 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.2 1.5 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.2 0.7 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.2 0.5 GO:0006531 aspartate metabolic process(GO:0006531)
0.2 0.5 GO:0015693 magnesium ion transport(GO:0015693)
0.2 19.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 0.8 GO:0000173 inactivation of MAPK activity involved in osmosensory signaling pathway(GO:0000173)
0.1 0.7 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 1.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.6 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.6 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.1 1.5 GO:0034963 box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963)
0.1 1.1 GO:0034221 cell wall chitin biosynthetic process(GO:0006038) fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.1 0.6 GO:0009312 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 2.8 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.1 0.3 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 1.2 GO:0006012 galactose metabolic process(GO:0006012)
0.1 1.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.4 GO:0045896 regulation of transcription during mitosis(GO:0045896)
0.1 1.0 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.1 1.0 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 0.5 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.4 GO:0007050 cell cycle arrest(GO:0007050)
0.1 0.6 GO:0007323 peptide pheromone maturation(GO:0007323)
0.1 0.3 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.1 1.3 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 0.6 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.5 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.3 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 0.3 GO:0000101 sulfur amino acid transport(GO:0000101)
0.1 0.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 3.8 GO:0009266 response to temperature stimulus(GO:0009266)
0.1 0.3 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.1 0.3 GO:1900436 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.1 0.2 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.1 0.9 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 1.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.3 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.1 2.8 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.1 1.7 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) negative regulation of proteasomal protein catabolic process(GO:1901799)
0.1 0.7 GO:0031506 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.1 0.9 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 0.3 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.1 0.5 GO:0015891 siderophore transport(GO:0015891)
0.1 1.4 GO:0006885 regulation of pH(GO:0006885)
0.1 0.3 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.1 1.7 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 0.2 GO:0036213 actomyosin contractile ring contraction(GO:0000916) actin filament-based movement(GO:0030048) contractile ring contraction(GO:0036213) actin filament-based transport(GO:0099515)
0.1 0.2 GO:0009187 cyclic nucleotide metabolic process(GO:0009187)
0.1 0.2 GO:0000296 spermine transport(GO:0000296)
0.1 0.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 0.3 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 1.4 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 0.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 0.4 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.1 0.2 GO:0006571 tyrosine biosynthetic process(GO:0006571) L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.0 0.5 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.9 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.0 0.6 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.2 GO:0046656 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.0 0.2 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.0 0.1 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.0 0.3 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0 1.1 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.1 GO:0015691 cadmium ion transport(GO:0015691)
0.0 0.1 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.0 0.2 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.0 0.7 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.4 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.2 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.1 GO:0034517 ribophagy(GO:0034517)
0.0 0.1 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 1.2 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.3 GO:0090002 protein localization to plasma membrane(GO:0072659) establishment of protein localization to plasma membrane(GO:0090002) protein localization to cell periphery(GO:1990778)
0.0 0.5 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.2 GO:2000278 regulation of telomere maintenance via telomerase(GO:0032210) regulation of telomere maintenance via telomere lengthening(GO:1904356) regulation of DNA biosynthetic process(GO:2000278)
0.0 0.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.0 0.7 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0046033 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.0 0.2 GO:0016233 telomere capping(GO:0016233)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 0.3 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.2 GO:0006779 porphyrin-containing compound metabolic process(GO:0006778) porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole metabolic process(GO:0033013) tetrapyrrole biosynthetic process(GO:0033014) heme metabolic process(GO:0042168)
0.0 0.1 GO:0000162 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.2 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.0 2.2 GO:0016072 rRNA metabolic process(GO:0016072)
0.0 0.5 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.0 0.0 GO:0035306 positive regulation of phosphatase activity(GO:0010922) positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.0 0.4 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.1 GO:0051668 localization within membrane(GO:0051668)
0.0 0.3 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.6 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.1 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.0 0.0 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 0.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.2 GO:0006415 translational termination(GO:0006415)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.1 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.1 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.0 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.0 0.1 GO:0016125 steroid metabolic process(GO:0008202) sterol metabolic process(GO:0016125)
0.0 0.2 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 0.0 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0000735 removal of nonhomologous ends(GO:0000735)
0.0 0.0 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0 0.1 GO:0043687 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.0 0.0 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.0 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.0 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.0 0.3 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.1 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.1 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.9 2.7 GO:0030428 cell septum(GO:0030428)
0.6 1.7 GO:0046930 pore complex(GO:0046930)
0.5 2.5 GO:0030689 Noc complex(GO:0030689)
0.4 1.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.4 1.7 GO:0000938 GARP complex(GO:0000938)
0.3 2.0 GO:0032126 eisosome(GO:0032126)
0.3 1.5 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.3 24.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 2.1 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.2 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 2.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 0.9 GO:0000815 ESCRT III complex(GO:0000815)
0.2 3.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 12.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 1.0 GO:0032545 CURI complex(GO:0032545)
0.2 0.8 GO:0000817 COMA complex(GO:0000817)
0.2 2.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 2.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 1.2 GO:0042597 periplasmic space(GO:0042597)
0.2 1.7 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.6 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 0.8 GO:0042555 MCM complex(GO:0042555)
0.1 0.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.1 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.1 0.4 GO:0000928 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.1 4.3 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.7 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 0.5 GO:0000811 GINS complex(GO:0000811)
0.1 0.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.7 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.1 GO:0005940 septin ring(GO:0005940) septin cytoskeleton(GO:0032156)
0.1 0.3 GO:0043529 GET complex(GO:0043529)
0.1 4.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.3 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.1 0.2 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 0.3 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.5 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 0.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 0.4 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 1.4 GO:0005844 polysome(GO:0005844)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.6 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.8 GO:0016586 RSC complex(GO:0016586)
0.0 0.1 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.0 0.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 1.3 GO:0005576 extracellular region(GO:0005576)
0.0 0.5 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.4 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.5 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.2 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.3 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.6 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 5.7 GO:0005933 cellular bud(GO:0005933)
0.0 0.2 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 4.3 GO:0005730 nucleolus(GO:0005730)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.6 GO:0070847 core mediator complex(GO:0070847)
0.0 0.0 GO:0005880 nuclear microtubule(GO:0005880)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.1 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0070772 PAS complex(GO:0070772)
0.0 1.0 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.0 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.0 0.1 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 0.1 GO:0044433 vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659) cytoplasmic vesicle part(GO:0044433)
0.0 0.0 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 8.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.1 4.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.1 4.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.7 2.9 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.6 3.9 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.6 1.7 GO:0005253 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.6 1.7 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.5 1.6 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.4 1.9 GO:0036002 pre-mRNA binding(GO:0036002)
0.4 1.5 GO:0004622 lysophospholipase activity(GO:0004622)
0.3 1.7 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.3 0.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3 0.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 0.9 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.3 0.9 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.3 0.8 GO:0022832 voltage-gated ion channel activity(GO:0005244) calcium channel activity(GO:0005262) voltage-gated channel activity(GO:0022832)
0.3 1.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 1.4 GO:0004707 MAP kinase activity(GO:0004707)
0.2 0.9 GO:0016854 ammonia-lyase activity(GO:0016841) racemase and epimerase activity(GO:0016854)
0.2 0.6 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.2 2.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 0.6 GO:0016504 peptidase activator activity(GO:0016504)
0.2 2.4 GO:0005199 structural constituent of cell wall(GO:0005199)
0.2 0.4 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.2 0.6 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.2 0.8 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 1.4 GO:0030145 manganese ion binding(GO:0030145)
0.2 4.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 1.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 1.1 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.2 1.8 GO:0030295 protein kinase activator activity(GO:0030295)
0.2 2.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 0.5 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.2 1.7 GO:0031386 protein tag(GO:0031386)
0.2 3.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.2 3.8 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 32.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.7 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.7 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.7 GO:0016408 C-acyltransferase activity(GO:0016408)
0.1 1.4 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.1 0.6 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.1 1.8 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.4 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 1.0 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 1.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 0.3 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.1 3.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 0.4 GO:0005034 osmosensor activity(GO:0005034)
0.1 0.3 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 0.4 GO:0004771 sterol esterase activity(GO:0004771)
0.1 0.1 GO:0015248 sterol transporter activity(GO:0015248)
0.1 1.2 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.3 GO:0016972 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) thiol oxidase activity(GO:0016972)
0.1 0.7 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.3 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.3 GO:0004100 chitin synthase activity(GO:0004100)
0.1 0.9 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.1 2.0 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 0.2 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.1 1.8 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 0.2 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.3 GO:0019201 nucleotide kinase activity(GO:0019201)
0.1 1.3 GO:0030515 snoRNA binding(GO:0030515)
0.1 1.9 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 3.9 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.1 0.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.1 2.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 0.6 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.1 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.6 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.1 0.2 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.1 1.0 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.1 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.2 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.1 0.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.8 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.2 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0004000 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.2 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.5 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.7 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
0.0 0.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.3 GO:0030276 clathrin binding(GO:0030276)
0.0 0.2 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.0 0.1 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.1 GO:0005216 ion channel activity(GO:0005216)
0.0 0.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0008443 phosphofructokinase activity(GO:0008443)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.1 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.8 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.2 GO:0019904 protein domain specific binding(GO:0019904)
0.0 1.4 GO:0003924 GTPase activity(GO:0003924)
0.0 0.2 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.2 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.1 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0015103 inorganic anion transmembrane transporter activity(GO:0015103)
0.0 0.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.3 GO:0032561 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.0 0.2 GO:0050661 NADP binding(GO:0050661)
0.0 0.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.0 0.2 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0030695 GTPase regulator activity(GO:0030695)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 PID E2F PATHWAY E2F transcription factor network
0.1 0.8 PID ATR PATHWAY ATR signaling pathway
0.0 0.1 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.1 PID FGF PATHWAY FGF signaling pathway
0.0 0.0 PID ATM PATHWAY ATM pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.3 7.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 1.2 REACTOME GPCR LIGAND BINDING Genes involved in GPCR ligand binding
0.1 0.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 0.6 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 0.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 0.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis