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Results for RIM101

Z-value: 2.50

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Transcription factors associated with RIM101

Gene Symbol Gene ID Gene Info
RIM101
S000001019 Cys2His2 zinc-finger transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RIM101YHL027W0.931.2e-11Click!

Activity profile of RIM101 motif

Sorted Z-values of RIM101 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YAL062W 47.04
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YJR095W 31.15
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YDR536W 30.71
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YKL163W 24.44
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YKL217W 22.60
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YOR383C 22.47
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOR382W 21.03
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YMR244W 20.26 Putative protein of unknown function
YMR017W 16.47
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YAL063C 14.82
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YMR107W 14.62
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YGL045W 13.79
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YLR122C 13.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YJL045W 13.23 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YOR393W 12.64
ERR1
Protein of unknown function, has similarity to enolases
YFL051C 12.59 Putative protein of unknown function; YFL051C is not an essential gene
YFL019C 12.24 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YGR087C 11.91
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YOR100C 11.64
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YOR378W 11.43 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YLR123C 11.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YDR043C 11.38
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YCR091W 11.12
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YDR342C 10.74
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YML131W 10.46 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YCR005C 9.97
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YMR081C 9.36
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YAL067C 9.33
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YMR056C 9.31
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YJR061W 9.28 Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p
YIL099W 9.24
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YJL116C 9.21
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YIL057C 9.17 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YDL210W 9.06
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YPR078C 8.87 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YGL096W 8.77
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YNL194C 8.71 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YKL148C 8.68
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YLR124W 8.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFR053C 8.64
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YNL125C 8.62
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YOR178C 8.55
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YKL109W 8.49
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YFL020C 8.43
PAU5
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YCL025C 8.43
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YPL054W 8.37
LEE1
Zinc-finger protein of unknown function
YMR206W 8.26 Putative protein of unknown function; YMR206W is not an essential gene
YOR192C 8.22
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YDR343C 8.22
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YOR391C 8.14
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YFL011W 8.07
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YOR192C-C 7.98 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YBR072W 7.76
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YOR072W 7.74 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YAL061W 7.69
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YDR533C 7.63
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YNR073C 7.61 Putative mannitol dehydrogenase
YHL041W 7.52 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YHR139C 7.45
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YOR072W-A 7.15 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YDR070C 7.13
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR125W 7.07 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YIL101C 7.06
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YKL028W 6.99
TFA1
TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YMR306W 6.99
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR088W 6.96
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YIL066C 6.83
RNR3
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YPL024W 6.75
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YOL084W 6.69
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YNR034W-A 6.64 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YPL036W 6.63
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YLR023C 6.63
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YOR071C 6.58
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YOR011W-A 6.45 Putative protein of unknown function
YPL250C 6.34
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YNL305C 6.30 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YNL018C 6.25 Putative protein of unknown function
YDR171W 6.21
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YMR090W 6.00 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YLR356W 6.00 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YIL086C 5.99 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL144C 5.90 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YPR015C 5.86 Putative protein of unknown function
YPR010C-A 5.81 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YML089C 5.76 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YEL039C 5.74
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YEL070W 5.74
DSF1
Deletion suppressor of mpt5 mutation
YLL060C 5.71
GTT2
Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YPL026C 5.68
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YLR304C 5.65
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YPL058C 5.61
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YAR023C 5.60 Putative integral membrane protein, member of DUP240 gene family
YIL166C 5.60 Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
YCL054W 5.58
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YKL085W 5.56
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YLR332W 5.34
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YPL018W 5.29
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YLR438W 5.29
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YOR010C 5.27
TIR2
Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
YKR096W 5.20 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc (PilT N terminus) domain
YGR144W 5.19
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YGL156W 5.19
AMS1
Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
YLR331C 5.18
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YDL218W 5.07 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YPL171C 5.04
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YJR115W 5.03 Putative protein of unknown function
YLL056C 4.95 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YER185W 4.91
PUG1
Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions
YAR069C 4.90 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL274C 4.88
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR181C 4.87 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YPL271W 4.85
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YBR182C 4.85
SMP1
Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors
YLR047C 4.85
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YGR142W 4.83
BTN2
v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YGR066C 4.82 Putative protein of unknown function
YIL087C 4.81
LRC2
Putative protein of unknown function; protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YAR070C 4.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR286C 4.79
BIO2
Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YCR007C 4.78 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YJR150C 4.73
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YKR067W 4.70
GPT2
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YOL118C 4.65 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YLR437C-A 4.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YFR029W 4.57
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YNL142W 4.55
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YPR065W 4.47
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YMR040W 4.42
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YFL052W 4.41 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YOR384W 4.38
FRE5
Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR009C 4.33
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YOR139C 4.32 Hypothetical protein
YEL060C 4.29
PRB1
Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YLL055W 4.28
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YGL072C 4.24 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YPL089C 4.23
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YOR140W 4.22
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YOR381W 4.21
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YIL100C-A 4.15 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR392W 4.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat
YOL035C 4.11 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL214C 4.09
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YKL171W 4.09 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YHR071W 4.08
PCL5
Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YER004W 4.02
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YIL024C 3.98 Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
YAL066W 3.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML054C 3.95
CYB2
Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YAR068W 3.93 Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YIL100W 3.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YCL040W 3.92
GLK1
Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YHL040C 3.91
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YIR039C 3.89
YPS6
Putative GPI-anchored aspartic protease
YLR402W 3.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR235C 3.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3
YLR236C 3.83 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR020C 3.83
PET18
Protein required for respiratory growth and stability of the mitochondrial genome
YBR200W-A 3.83 Putative protein of unknown function; identified by fungal homology and RT-PCR
YER184C 3.78 Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source
YCL042W 3.78 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YBL049W 3.74
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YFL003C 3.73
MSH4
Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
YOR186W 3.72 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YHR080C 3.70 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR176W 3.70
FMO1
Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
YIL113W 3.68
SDP1
Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
YOL052C-A 3.68
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YOL100W 3.65
PKH2
Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YLR403W 3.63
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YHR008C 3.61
SOD2
Mitochondrial superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YDR186C 3.60 Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDL170W 3.60
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YIL102C 3.58 Putative protein of unknown function
YFL030W 3.53
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YJL163C 3.53 Putative protein of unknown function
YKL029C 3.48
MAE1
Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
YJR038C 3.47 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL004W 3.47
AUR1
Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
YKL005C 3.47
BYE1
Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
YKL146W 3.45
AVT3
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YML090W 3.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YNL036W 3.40
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YBR145W 3.40
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YJL056C 3.40
ZAP1
Zinc-regulated transcription factor, binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc; regulates its own transcription; contains seven zinc-finger domains
YOL075C 3.39 Putative ABC transporter
YPL150W 3.38 Putative protein kinase of unknown cellular role
YKL147C 3.37 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YKR066C 3.37
CCP1
Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YNL074C 3.35
MLF3
Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YER065C 3.34
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YPL230W 3.32
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YPL189C-A 3.31
COA2
Putative cytochrome oxidase assembly factor; identified by homology to Ashbya gossypii; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity
YLR273C 3.30
PIG1
Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
YLR121C 3.29
YPS3
Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YNL133C 3.28
FYV6
Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining
YDR277C 3.27
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YML083C 3.26 Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
YNL055C 3.20
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YNR063W 3.20 Putative zinc-cluster protein of unknown function
YDR085C 3.18
AFR1
Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p

Network of associatons between targets according to the STRING database.

First level regulatory network of RIM101

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.4 46.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
10.4 31.2 GO:0015740 C4-dicarboxylate transport(GO:0015740)
6.1 48.5 GO:0015891 siderophore transport(GO:0015891)
5.9 17.8 GO:0015888 thiamine transport(GO:0015888)
5.9 29.3 GO:0015793 glycerol transport(GO:0015793)
5.7 22.6 GO:0006848 pyruvate transport(GO:0006848)
3.6 14.2 GO:0015886 heme transport(GO:0015886)
3.5 10.4 GO:0015755 fructose transport(GO:0015755)
3.4 10.3 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
3.4 10.2 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
3.4 20.5 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
2.9 11.8 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
2.9 8.7 GO:0006013 mannose metabolic process(GO:0006013)
2.6 10.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
2.2 8.9 GO:0015847 putrescine transport(GO:0015847)
2.2 6.6 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
2.2 43.8 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
2.0 8.1 GO:0006108 malate metabolic process(GO:0006108)
2.0 18.2 GO:0046487 glyoxylate metabolic process(GO:0046487)
2.0 7.9 GO:0006527 arginine catabolic process(GO:0006527)
2.0 17.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.8 9.2 GO:0005980 glycogen catabolic process(GO:0005980)
1.8 1.8 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
1.7 7.0 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
1.7 8.7 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.7 6.8 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
1.6 4.9 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.4 2.8 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
1.4 4.1 GO:0006545 glycine biosynthetic process(GO:0006545)
1.3 2.7 GO:0006102 isocitrate metabolic process(GO:0006102)
1.3 19.5 GO:0031321 ascospore-type prospore assembly(GO:0031321)
1.3 2.6 GO:0006538 glutamate catabolic process(GO:0006538)
1.2 3.7 GO:1903137 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
1.2 3.6 GO:0001315 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
1.2 10.8 GO:0045332 phospholipid translocation(GO:0045332)
1.1 4.6 GO:0043200 response to amino acid(GO:0043200)
1.1 4.5 GO:0070054 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
1.1 4.2 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
1.0 17.8 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
1.0 3.1 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.0 16.6 GO:0006754 ATP biosynthetic process(GO:0006754)
1.0 3.0 GO:0030808 regulation of cyclic nucleotide metabolic process(GO:0030799) regulation of cyclic nucleotide biosynthetic process(GO:0030802) regulation of nucleotide biosynthetic process(GO:0030808) regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of purine nucleotide biosynthetic process(GO:1900371)
1.0 2.9 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.9 3.7 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.9 16.7 GO:0006772 thiamine metabolic process(GO:0006772)
0.9 2.8 GO:0045117 azole transport(GO:0045117)
0.9 3.6 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.9 6.3 GO:0000023 maltose metabolic process(GO:0000023)
0.9 13.9 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.9 7.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.9 3.4 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.9 3.4 GO:0015976 carbon utilization(GO:0015976)
0.9 4.3 GO:0032108 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108) negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.8 0.8 GO:0006119 oxidative phosphorylation(GO:0006119)
0.8 4.1 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.8 2.5 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.8 3.1 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.8 7.0 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.8 4.6 GO:0006089 lactate metabolic process(GO:0006089)
0.7 2.1 GO:0015691 cadmium ion transport(GO:0015691)
0.7 2.1 GO:0055088 lipid homeostasis(GO:0055088)
0.7 3.4 GO:0034486 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.7 9.3 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.6 3.9 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.6 5.6 GO:0031167 rRNA methylation(GO:0031167)
0.6 1.8 GO:0006824 cobalt ion transport(GO:0006824)
0.6 2.9 GO:0072337 modified amino acid transport(GO:0072337)
0.5 7.0 GO:0006749 glutathione metabolic process(GO:0006749)
0.5 4.8 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.5 2.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.5 3.2 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.5 2.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.5 1.5 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.5 0.5 GO:0019627 urea metabolic process(GO:0019627) urea catabolic process(GO:0043419)
0.5 3.3 GO:0006083 acetate metabolic process(GO:0006083)
0.5 0.5 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.4 1.3 GO:0015851 nucleobase transport(GO:0015851)
0.4 0.8 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.4 1.2 GO:0015677 copper ion import(GO:0015677)
0.4 8.8 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.4 0.4 GO:0009730 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.3 2.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.3 0.7 GO:0043335 protein unfolding(GO:0043335)
0.3 3.7 GO:0000710 meiotic mismatch repair(GO:0000710)
0.3 7.0 GO:0016579 protein deubiquitination(GO:0016579)
0.3 1.0 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.3 7.8 GO:0012501 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.3 6.5 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.3 1.6 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.3 2.9 GO:0070987 error-free translesion synthesis(GO:0070987)
0.3 1.3 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.3 5.4 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.3 0.9 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.3 3.1 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 10.6 GO:0006865 amino acid transport(GO:0006865)
0.3 0.9 GO:0043954 cellular component maintenance(GO:0043954)
0.3 0.9 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.3 1.2 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.3 3.0 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.3 2.1 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.3 6.2 GO:0022900 electron transport chain(GO:0022900)
0.3 0.9 GO:0044209 AMP salvage(GO:0044209)
0.3 1.4 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.3 1.4 GO:0001881 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.3 3.0 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.3 1.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.3 1.6 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.3 3.5 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.3 0.3 GO:0006740 NADPH regeneration(GO:0006740)
0.3 0.8 GO:0042843 D-xylose catabolic process(GO:0042843)
0.3 1.6 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.3 1.8 GO:0006829 zinc II ion transport(GO:0006829)
0.3 1.8 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.3 1.5 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.3 0.8 GO:0050685 positive regulation of mRNA processing(GO:0050685)
0.3 1.8 GO:0043461 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.3 0.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 9.8 GO:0009060 aerobic respiration(GO:0009060)
0.2 0.7 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.2 1.0 GO:0006598 polyamine catabolic process(GO:0006598)
0.2 1.4 GO:0045013 carbon catabolite repression of transcription(GO:0045013)
0.2 1.6 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.2 1.3 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.2 8.6 GO:0042244 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.2 0.7 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.2 0.9 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 1.8 GO:0046686 response to cadmium ion(GO:0046686)
0.2 0.8 GO:0001927 exocyst assembly(GO:0001927)
0.2 1.0 GO:0060628 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport(GO:0060628) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.2 1.0 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.2 1.1 GO:0006452 translational frameshifting(GO:0006452)
0.2 0.9 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.2 3.0 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 0.7 GO:2000909 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.2 0.8 GO:0034551 respiratory chain complex III assembly(GO:0017062) protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.2 0.2 GO:0070726 cell wall assembly(GO:0070726)
0.2 1.7 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.2 0.9 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.1 0.7 GO:0031397 negative regulation of protein ubiquitination(GO:0031397) negative regulation of protein modification by small protein conjugation or removal(GO:1903321)
0.1 0.6 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.1 0.8 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.1 1.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.1 2.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.3 GO:0042762 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of sulfur metabolic process(GO:0042762)
0.1 0.6 GO:0070058 tRNA gene clustering(GO:0070058)
0.1 0.4 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 0.7 GO:0030100 regulation of endocytosis(GO:0030100)
0.1 1.1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.1 0.7 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.1 0.8 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 0.2 GO:0051098 DNA-templated transcriptional open complex formation(GO:0001112) protein-DNA complex remodeling(GO:0001120) macromolecular complex remodeling(GO:0034367) regulation of binding(GO:0051098)
0.1 0.8 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.8 GO:0031578 mitotic spindle orientation checkpoint(GO:0031578)
0.1 0.8 GO:0060260 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) regulation of transcription initiation from RNA polymerase II promoter(GO:0060260) regulation of DNA-templated transcription, initiation(GO:2000142)
0.1 0.4 GO:0019346 transsulfuration(GO:0019346)
0.1 1.2 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.5 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.1 0.4 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.3 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.1 0.4 GO:0001678 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to carbohydrate stimulus(GO:0071322) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.1 0.5 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.1 0.7 GO:0006638 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.1 0.3 GO:0051260 protein homooligomerization(GO:0051260)
0.1 0.3 GO:0051382 centromere complex assembly(GO:0034508) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.1 0.8 GO:0030952 establishment or maintenance of actin cytoskeleton polarity(GO:0030950) establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.1 0.2 GO:0000348 mRNA branch site recognition(GO:0000348)
0.1 0.3 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.1 0.3 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.8 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.4 GO:0097502 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.1 1.1 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.1 0.3 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 0.2 GO:0090114 COPII-coated vesicle budding(GO:0090114)
0.1 0.2 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.1 0.3 GO:0016233 telomere capping(GO:0016233)
0.1 0.3 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.1 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.3 GO:0000279 mitotic M phase(GO:0000087) M phase(GO:0000279)
0.0 0.1 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 0.7 GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0000750) signal transduction involved in conjugation with cellular fusion(GO:0032005)
0.0 0.2 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.6 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.2 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.4 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.1 GO:0043937 regulation of sporulation resulting in formation of a cellular spore(GO:0042173) regulation of sporulation(GO:0043937)
0.0 0.2 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.2 GO:0006112 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.0 0.1 GO:0060988 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.0 0.3 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.0 0.2 GO:0000755 cytogamy(GO:0000755)
0.0 0.4 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.2 GO:0006265 DNA topological change(GO:0006265)
0.0 0.3 GO:0055074 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.0 0.2 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.0 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.0 0.4 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.2 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.1 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.0 GO:0097035 lipid translocation(GO:0034204) regulation of membrane lipid distribution(GO:0097035)
0.0 0.0 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.2 GO:0030437 ascospore formation(GO:0030437) cell development(GO:0048468)
0.0 0.1 GO:0051181 cofactor transport(GO:0051181)
0.0 0.0 GO:0046040 IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0 0.0 GO:0017004 cytochrome complex assembly(GO:0017004)
0.0 0.4 GO:0030435 sporulation resulting in formation of a cellular spore(GO:0030435)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
2.5 10.1 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
2.4 9.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
2.3 6.8 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
1.7 8.7 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.7 3.4 GO:0001400 mating projection base(GO:0001400)
1.6 4.9 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
1.5 12.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.2 4.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.1 18.0 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
1.1 3.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.9 2.6 GO:0032176 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.9 20.4 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.8 0.8 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.8 10.2 GO:0005619 ascospore wall(GO:0005619)
0.8 3.1 GO:0000817 COMA complex(GO:0000817)
0.8 3.8 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.7 33.5 GO:0031225 anchored component of membrane(GO:0031225)
0.7 2.1 GO:0005784 Sec61 translocon complex(GO:0005784)
0.7 4.6 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.6 5.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.5 11.7 GO:0070469 respiratory chain(GO:0070469)
0.5 3.0 GO:0032126 eisosome(GO:0032126)
0.5 5.0 GO:0032300 mismatch repair complex(GO:0032300)
0.5 1.4 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.4 2.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.4 1.6 GO:0033551 monopolin complex(GO:0033551)
0.4 1.2 GO:0000814 ESCRT II complex(GO:0000814)
0.4 2.6 GO:0034657 GID complex(GO:0034657)
0.3 6.1 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.3 1.3 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.3 0.9 GO:0030874 nucleolar chromatin(GO:0030874)
0.3 2.4 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.3 2.3 GO:0098797 plasma membrane protein complex(GO:0098797)
0.3 44.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 1.6 GO:0008180 COP9 signalosome(GO:0008180)
0.3 0.8 GO:0032585 multivesicular body membrane(GO:0032585)
0.3 1.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 4.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.2 2.5 GO:0000974 Prp19 complex(GO:0000974)
0.2 83.3 GO:0005886 plasma membrane(GO:0005886)
0.2 1.9 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.2 1.4 GO:0031499 TRAMP complex(GO:0031499)
0.2 5.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 2.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.2 3.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 1.5 GO:0005801 cis-Golgi network(GO:0005801)
0.2 6.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 24.1 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.2 1.6 GO:0005769 early endosome(GO:0005769)
0.2 1.9 GO:0000942 condensed chromosome outer kinetochore(GO:0000940) condensed nuclear chromosome outer kinetochore(GO:0000942)
0.2 0.6 GO:0032116 SMC loading complex(GO:0032116)
0.2 0.5 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.2 1.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 8.9 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.3 GO:0043291 RAVE complex(GO:0043291)
0.1 0.4 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 0.4 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.4 GO:0005787 signal peptidase complex(GO:0005787)
0.1 6.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.4 GO:0034099 luminal surveillance complex(GO:0034099)
0.1 0.3 GO:0051286 cell tip(GO:0051286)
0.1 0.3 GO:0031518 CBF3 complex(GO:0031518)
0.1 1.9 GO:0005795 Golgi stack(GO:0005795)
0.1 0.3 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.2 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 53.0 GO:0005739 mitochondrion(GO:0005739)
0.1 1.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.7 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.1 0.2 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 1.1 GO:0033698 Rpd3L complex(GO:0033698)
0.1 0.1 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.1 0.9 GO:0000812 Swr1 complex(GO:0000812)
0.1 1.2 GO:0030312 cell wall(GO:0005618) external encapsulating structure(GO:0030312)
0.1 3.8 GO:0043332 mating projection tip(GO:0043332)
0.1 1.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 0.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.1 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 0.4 GO:0031011 Ino80 complex(GO:0031011)
0.1 1.1 GO:0005844 polysome(GO:0005844)
0.0 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 1.5 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.3 GO:0016586 RSC complex(GO:0016586)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
13.0 64.8 GO:0015295 solute:proton symporter activity(GO:0015295)
11.5 46.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
7.8 31.2 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
4.5 18.0 GO:0005537 mannose binding(GO:0005537)
4.4 13.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
3.8 11.5 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
3.5 13.9 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
3.4 10.1 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
3.1 12.6 GO:0004396 hexokinase activity(GO:0004396)
2.9 11.8 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
2.3 11.7 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
2.3 9.3 GO:0005471 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
2.2 22.3 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
2.0 8.1 GO:0016615 malate dehydrogenase activity(GO:0016615)
1.7 7.0 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
1.7 8.7 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.6 14.5 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
1.6 6.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.6 14.2 GO:0015293 symporter activity(GO:0015293)
1.3 2.7 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
1.3 2.7 GO:1901474 azole transmembrane transporter activity(GO:1901474)
1.3 5.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
1.2 3.7 GO:0033549 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
1.2 4.9 GO:0004457 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
1.2 4.7 GO:0016725 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.2 18.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.1 3.4 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
1.1 7.9 GO:0004364 glutathione transferase activity(GO:0004364)
1.1 10.1 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
1.1 6.7 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
1.1 6.5 GO:0000400 four-way junction DNA binding(GO:0000400)
1.1 5.3 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
1.0 3.9 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
1.0 11.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.0 3.8 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.9 10.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.9 4.5 GO:0008198 ferrous iron binding(GO:0008198)
0.9 9.8 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.9 0.9 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.8 12.3 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.8 1.6 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.8 1.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.7 3.7 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.7 2.0 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.6 1.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.6 19.2 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.6 15.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.6 26.0 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.6 1.8 GO:0004100 chitin synthase activity(GO:0004100)
0.6 0.6 GO:0032451 demethylase activity(GO:0032451) histone demethylase activity(GO:0032452)
0.6 5.0 GO:0030983 mismatched DNA binding(GO:0030983)
0.6 1.7 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.6 1.7 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.6 5.0 GO:0000149 SNARE binding(GO:0000149)
0.6 1.7 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.5 2.7 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.5 9.4 GO:0008301 DNA binding, bending(GO:0008301)
0.5 1.9 GO:0008172 S-methyltransferase activity(GO:0008172)
0.5 3.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.5 0.9 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.4 3.0 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.4 4.8 GO:0035064 methylated histone binding(GO:0035064)
0.4 4.8 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.4 1.2 GO:0030332 cyclin binding(GO:0030332)
0.4 3.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.4 1.2 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.4 1.1 GO:0016880 AMP binding(GO:0016208) CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878) acid-ammonia (or amide) ligase activity(GO:0016880)
0.4 0.4 GO:0048029 monosaccharide binding(GO:0048029)
0.3 8.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.3 2.3 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.3 1.0 GO:0000150 recombinase activity(GO:0000150)
0.3 1.0 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.3 2.5 GO:0005057 receptor signaling protein activity(GO:0005057)
0.3 0.9 GO:0070569 uridylyltransferase activity(GO:0070569)
0.3 5.5 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.3 0.9 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.3 3.5 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.3 3.1 GO:0099600 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.3 2.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.3 0.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 2.1 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.9 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.2 1.6 GO:0019238 cyclohydrolase activity(GO:0019238)
0.2 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.2 3.6 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.2 0.8 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 1.2 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 1.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 0.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 0.5 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.2 1.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.2 3.2 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.2 0.6 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.9 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 2.0 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 1.1 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1 1.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 0.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 4.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 2.3 GO:0051287 NAD binding(GO:0051287)
0.1 2.5 GO:0050662 coenzyme binding(GO:0050662)
0.1 3.0 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.6 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.4 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.4 GO:0015386 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.1 0.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.2 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.1 2.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 0.4 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 0.5 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 0.4 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.1 0.2 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.1 6.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 1.5 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 0.4 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 0.4 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.6 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 0.4 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.4 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.1 0.4 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.7 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.2 GO:0005509 calcium ion binding(GO:0005509)
0.1 1.5 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.1 GO:0045118 azole transporter activity(GO:0045118)
0.0 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.8 GO:0030515 snoRNA binding(GO:0030515)
0.0 3.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.1 GO:0017022 myosin binding(GO:0017022)
0.0 0.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.0 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.0 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.2 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.1 GO:0051184 cofactor transporter activity(GO:0051184)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
2.3 2.3 PID AR PATHWAY Coregulation of Androgen receptor activity
1.4 4.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.4 7.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
1.1 3.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.9 2.6 PID FOXO PATHWAY FoxO family signaling
0.9 6.9 PID FANCONI PATHWAY Fanconi anemia pathway
0.7 2.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.4 0.7 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.2 304.7 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.2 0.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 0.6 PID NOTCH PATHWAY Notch signaling pathway
0.2 0.2 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 0.3 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.1 0.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 6.0 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
2.4 7.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
1.4 2.7 REACTOME DNA REPAIR Genes involved in DNA Repair
1.0 2.9 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.9 3.7 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.7 6.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.4 3.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.3 0.7 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.3 2.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 1.2 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 304.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 0.2 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.1 0.3 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.1 0.4 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.1 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.1 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane