Navigation
Downloads

Results for ROX1

Z-value: 1.18

Motif logo

logo of

Transcription factors associated with ROX1

Gene Symbol Gene ID Gene Info
ROX1
S000006269 Heme-dependent repressor of hypoxic genes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ROX1YPR065W-0.714.1e-05Click!

Activity profile of ROX1 motif

Sorted Z-values of ROX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 18.16
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 16.76 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YOL086C 10.73
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YCR018C 7.54
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YDR033W 7.50
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YKR038C 7.37
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YNR001W-A 7.32 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YHR181W 6.73
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YDR044W 6.67
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YGR108W 6.34
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YNL111C 5.44
CYB5
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YOL056W 5.00
GPM3
Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YKL218C 4.99
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YHR180W-A 4.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YER011W 4.65
TIR1
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YOL085C 4.48 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YFR054C 4.45 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR226C 4.42
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YHR007C 4.31
ERG11
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YDR385W 4.19
EFT2
Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YPR063C 4.17 ER-localized protein of unknown function
YMR199W 3.97
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YBR238C 3.96 Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
YDR509W 3.80 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR315W 3.74
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YMR119W 3.69
ASI1
Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YGR214W 3.66
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YLR413W 3.66 Putative protein of unknown function; YLR413W is not an essential gene
YLR355C 3.59
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YIL118W 3.59
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YDR508C 3.58
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YMR246W 3.51
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YNR054C 3.51
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YPL250W-A 3.46 Identified by fungal homology and RT-PCR
YOR342C 3.45 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YJL157C 3.43
FAR1
Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate
YLR154C 3.42
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YGL179C 3.34
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YDR002W 3.34
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YIR021W 3.31
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YKR092C 3.30
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YKL182W 3.26
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YML111W 3.12
BUL2
Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1
YLL045C 3.12
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YMR032W 3.09
HOF1
Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YDR384C 3.08
ATO3
Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YAL029C 3.08
MYO4
One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
YNR018W 3.02
AIM38
Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YJL011C 2.97
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YOR369C 2.96
RPS12
Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YDR344C 2.95 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR029W 2.93 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGR040W 2.85
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YKL096W-A 2.85
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YJR047C 2.82
ANB1
Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions
YMR106C 2.81
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YBR087W 2.81
RFC5
Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YLR448W 2.81
RPL6B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YMR177W 2.79
MMT1
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YDR279W 2.77
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YML075C 2.75
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YOR028C 2.73
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YBL092W 2.72
RPL32
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YDR497C 2.71
ITR1
Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YER131W 2.68
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YML024W 2.65
RPS17A
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein
YHR052W 2.64
CIC1
Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
YKL152C 2.61
GPM1
Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YNR013C 2.57
PHO91
Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YBR011C 2.57
IPP1
Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YGL039W 2.54 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YIL053W 2.49
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YNL069C 2.47
RPL16B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YBR202W 2.45
MCM7
Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YMR049C 2.41
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YER137C 2.41 Putative protein of unknown function
YDR345C 2.37
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YIL011W 2.37
TIR3
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YOR332W 2.35
VMA4
Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YJL188C 2.35
BUD19
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YDR417C 2.35 Hypothetical protein
YEL054C 2.35
RPL12A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YLR154W-B 2.35 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YOR008C-A 2.31 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YIL111W 2.30
COX5B
Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth
YLR154W-A 2.28 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YDR037W 2.24
KRS1
Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YBR265W 2.23
TSC10
3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
YOL014W 2.22 Putative protein of unknown function
YGR138C 2.21
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YBR084C-A 2.21
RPL19A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YJR123W 2.19
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YHR208W 2.18
BAT1
Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
YJL153C 2.17
INO1
Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YDR112W 2.16
IRC2
Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
YHR182C-A 2.16 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR015C 2.13
ERG5
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YPR170W-B 2.13 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YGR176W 2.13 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL014W 2.12
NOP1
Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YAL038W 2.11
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YGR140W 2.11
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YHR183W 2.11
GND1
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YMR083W 2.10
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YBR210W 2.10
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YMR208W 2.10
ERG12
Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YBR104W 2.07
YMC2
Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YBR249C 2.07
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YDR465C 2.04
RMT2
Arginine methyltransferase; ribosomal protein L12 is a substrate
YCR006C 2.03 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL200C 2.03
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YPL243W 2.02
SRP68
Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
YCL018W 2.01
LEU2
Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YLR257W 1.99 Putative protein of unknown function
YPR170W-A 1.99 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YNL289W 1.97
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YGL158W 1.96
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YJR070C 1.95
LIA1
Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YJR071W 1.92 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR016W 1.92 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene
YJR057W 1.90
CDC8
Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
YLR198C 1.90 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
YOR153W 1.90
PDR5
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YMR194C-A 1.88 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR126W-A 1.87 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YDL205C 1.87
HEM3
Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p
YOR096W 1.85
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YGL225W 1.84
VRG4
Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YJL090C 1.84
DPB11
Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control
YOL149W 1.83
DCP1
Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p
YPR102C 1.82
RPL11A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YOL124C 1.81
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YLR180W 1.81
SAM1
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YJL008C 1.80
CCT8
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YEL051W 1.78
VMA8
Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YNR003C 1.76
RPC34
RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YMR205C 1.75
PFK2
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YPL256C 1.75
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YKL219W 1.74
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGL021W 1.74
ALK1
Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins
YER012W 1.73
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YGR086C 1.72
PIL1
Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YLR312W-A 1.70
MRPL15
Mitochondrial ribosomal protein of the large subunit
YER109C 1.69
FLO8
Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
YDR091C 1.68
RLI1
Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YGL001C 1.66
ERG26
C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YKL212W 1.66
SAC1
Phosphatidylinositol (PI) phosphatase, involved in hydrolysis of PI 3-phosphate, PI 4-phosphate and PI 3,5-bisphosphate to PI; membrane protein localizes to ER and Golgi; involved in protein trafficking, secretion and inositol metabolism
YCR019W 1.66
MAK32
Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YER102W 1.65
RPS8B
Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YKL081W 1.65
TEF4
Translation elongation factor EF-1 gamma
YGL157W 1.65 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YIL074C 1.64
SER33
3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p
YLL044W 1.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
YOR254C 1.63
SEC63
Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YEL053W-A 1.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YNL178W 1.62
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YDL047W 1.61
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YDR086C 1.61
SSS1
Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YEL027W 1.61
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YIL148W 1.61
RPL40A
Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YKR043C 1.61 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YKL030W 1.60 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
YOR030W 1.60
DFG16
Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
YOR011W 1.60
AUS1
Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YGL148W 1.59
ARO2
Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YEL029C 1.59
BUD16
Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YLR132C 1.58 Protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene
YLR110C 1.58
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YKR026C 1.58
GCN3
Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YGR251W 1.58 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YER070W 1.57
RNR1
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YDR146C 1.57
SWI5
Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YGL040C 1.57
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YLL027W 1.57
ISA1
Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources
YHR062C 1.56
RPP1
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YMR321C 1.56 Putative protein of unknown function
YOR310C 1.56
NOP58
Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YHR203C 1.54
RPS4B
Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YOR206W 1.54
NOC2
Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
YDR111C 1.53
ALT2
Putative alanine transaminase (glutamic pyruvic transaminase)
YKL008C 1.52
LAC1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YGR090W 1.51
UTP22
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YLR249W 1.51
YEF3
Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YGR027C 1.49
RPS25A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YOR222W 1.48
ODC2
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YKL110C 1.48
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YOR314W 1.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL265W 1.45
DIP5
Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YLR150W 1.45
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YHR152W 1.45
SPO12
Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
YJR016C 1.44
ILV3
Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
YLR254C 1.44
NDL1
Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
YBR085W 1.43
AAC3
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YBR130C 1.43
SHE3
Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
YPL037C 1.43
EGD1
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YLR210W 1.43
CLB4
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
YKL060C 1.43
FBA1
Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YMR290W-A 1.43 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YGR106C 1.42
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YKL080W 1.41
VMA5
Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane

Network of associatons between targets according to the STRING database.

First level regulatory network of ROX1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 17.9 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
2.6 7.7 GO:0045901 positive regulation of translational elongation(GO:0045901)
1.4 2.8 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
1.4 5.5 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
1.3 9.2 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
1.2 8.7 GO:0019660 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
1.2 7.4 GO:0009099 valine biosynthetic process(GO:0009099)
1.2 4.9 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
1.1 4.6 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
1.1 3.3 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
1.1 7.5 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.9 3.7 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.9 3.6 GO:0090337 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.9 3.6 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.9 6.2 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.9 7.7 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.8 2.5 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.8 3.9 GO:0007535 donor selection(GO:0007535)
0.8 6.9 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.7 2.9 GO:0000296 spermine transport(GO:0000296)
0.7 0.7 GO:0042710 biofilm formation(GO:0042710)
0.7 2.8 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.6 0.6 GO:0035950 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.6 1.2 GO:0016093 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
0.6 6.8 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.6 1.8 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.6 8.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.6 1.8 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
0.6 4.7 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.6 1.7 GO:0043171 peptide catabolic process(GO:0043171)
0.5 1.1 GO:0009847 spore germination(GO:0009847)
0.5 2.7 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.5 1.6 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.5 1.5 GO:1901351 regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
0.5 1.0 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.5 16.5 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.5 3.0 GO:0007030 Golgi organization(GO:0007030)
0.5 4.9 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.5 2.4 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.5 1.5 GO:0043069 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.5 1.9 GO:0030497 fatty acid elongation(GO:0030497)
0.5 1.4 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.5 1.9 GO:0006657 CDP-choline pathway(GO:0006657)
0.5 2.8 GO:0006021 inositol biosynthetic process(GO:0006021)
0.5 0.9 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.5 7.3 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.5 1.8 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.4 1.3 GO:0043902 starch metabolic process(GO:0005982) starch catabolic process(GO:0005983) regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter(GO:0035956) positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0035957) positive regulation of multi-organism process(GO:0043902) regulation of starch catabolic process(GO:2000881) positive regulation of starch catabolic process(GO:2000883) regulation of starch metabolic process(GO:2000904) positive regulation of starch metabolic process(GO:2000906)
0.4 2.7 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.4 0.9 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.4 0.9 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.4 2.6 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.4 4.3 GO:0090662 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.4 1.7 GO:0045896 regulation of transcription during mitosis(GO:0045896)
0.4 3.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.4 2.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.4 3.3 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.4 2.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.4 1.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.4 1.2 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.4 1.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.4 1.9 GO:0009098 leucine biosynthetic process(GO:0009098)
0.4 3.7 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.4 4.5 GO:0034963 box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963)
0.4 1.5 GO:0000433 negative regulation of transcription from RNA polymerase II promoter by glucose(GO:0000433) negative regulation of transcription by glucose(GO:0045014)
0.4 1.1 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.4 45.5 GO:0002181 cytoplasmic translation(GO:0002181)
0.3 0.3 GO:0043067 regulation of cell death(GO:0010941) regulation of apoptotic process(GO:0042981) regulation of programmed cell death(GO:0043067)
0.3 4.5 GO:0007120 axial cellular bud site selection(GO:0007120)
0.3 7.5 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.3 1.4 GO:0019365 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.3 4.1 GO:0006415 translational termination(GO:0006415)
0.3 2.7 GO:0006272 leading strand elongation(GO:0006272)
0.3 1.3 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.3 1.9 GO:0070941 eisosome assembly(GO:0070941)
0.3 2.5 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.3 1.8 GO:0035376 sterol import(GO:0035376)
0.3 1.2 GO:0036213 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.3 1.8 GO:0006116 NADH oxidation(GO:0006116)
0.3 0.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.3 1.2 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.3 1.5 GO:0060304 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.3 1.7 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.3 2.9 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.3 3.4 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.3 0.9 GO:0009394 pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate biosynthetic process(GO:0046385)
0.3 1.1 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.3 1.1 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.3 2.5 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.3 1.3 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.3 0.8 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.3 1.9 GO:0034063 stress granule assembly(GO:0034063)
0.3 4.5 GO:0030488 tRNA methylation(GO:0030488)
0.3 1.6 GO:0006448 regulation of translational elongation(GO:0006448)
0.3 1.3 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 2.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.3 7.3 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.3 0.8 GO:2001021 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.2 0.7 GO:0006571 tyrosine biosynthetic process(GO:0006571)
0.2 1.0 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.2 1.7 GO:0015791 polyol transport(GO:0015791)
0.2 0.7 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2 2.9 GO:0000921 septin ring assembly(GO:0000921)
0.2 0.2 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.2 0.9 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.2 1.7 GO:0006814 sodium ion transport(GO:0006814)
0.2 0.9 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 1.4 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.2 2.8 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.2 1.8 GO:0031506 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.2 0.4 GO:0015886 heme transport(GO:0015886)
0.2 0.7 GO:1900062 regulation of cell aging(GO:0090342) regulation of replicative cell aging(GO:1900062)
0.2 3.1 GO:0006885 regulation of pH(GO:0006885)
0.2 3.3 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.2 1.1 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.2 1.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.2 0.2 GO:0045337 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.2 1.9 GO:0071966 cell wall chitin biosynthetic process(GO:0006038) fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.2 0.8 GO:0007157 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.2 0.8 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.2 0.6 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.2 0.4 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.2 5.3 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.2 0.6 GO:0072523 adenine metabolic process(GO:0046083) nucleobase catabolic process(GO:0046113) purine-containing compound catabolic process(GO:0072523)
0.2 1.0 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.2 2.2 GO:0006446 regulation of translational initiation(GO:0006446)
0.2 1.0 GO:0042435 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.2 0.6 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.2 0.2 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.2 0.8 GO:0006563 L-serine metabolic process(GO:0006563)
0.2 0.6 GO:0051446 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.2 0.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.2 1.3 GO:0007323 peptide pheromone maturation(GO:0007323)
0.2 0.4 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.2 1.3 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.2 0.6 GO:0015680 intracellular copper ion transport(GO:0015680)
0.2 1.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.2 0.7 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.2 1.6 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.2 0.9 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.2 0.7 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.2 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.2 3.7 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.2 2.2 GO:0042255 ribosome assembly(GO:0042255)
0.2 0.5 GO:0019413 acetate biosynthetic process(GO:0019413)
0.2 0.7 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.2 2.3 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 3.1 GO:0006278 RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004) telomere maintenance via telomere lengthening(GO:0010833)
0.2 2.3 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.2 1.3 GO:0006614 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2 0.6 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 1.0 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 1.3 GO:0016074 snoRNA metabolic process(GO:0016074)
0.1 0.3 GO:0031555 regulation of DNA-templated transcription, termination(GO:0031554) transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.1 0.6 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.1 0.1 GO:0031106 septin ring organization(GO:0031106)
0.1 0.4 GO:0006801 superoxide metabolic process(GO:0006801)
0.1 0.9 GO:0006273 lagging strand elongation(GO:0006273)
0.1 0.7 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.1 0.7 GO:0001301 progressive alteration of chromatin involved in cell aging(GO:0001301)
0.1 2.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 0.4 GO:0032006 regulation of TOR signaling(GO:0032006)
0.1 0.8 GO:0071028 nuclear mRNA surveillance(GO:0071028)
0.1 1.6 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.5 GO:0030834 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.1 2.1 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 3.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 2.2 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.1 0.4 GO:0023021 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 0.3 GO:0010978 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.1 0.9 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 2.4 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.1 0.5 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 0.6 GO:0043007 maintenance of rDNA(GO:0043007)
0.1 4.6 GO:0044744 protein targeting to nucleus(GO:0044744)
0.1 14.5 GO:0006364 rRNA processing(GO:0006364)
0.1 0.4 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.1 0.1 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.4 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.1 0.5 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.1 1.2 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 2.0 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 3.3 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.1 GO:0033182 regulation of histone ubiquitination(GO:0033182)
0.1 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.1 1.1 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 3.1 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.2 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 0.6 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.1 0.3 GO:0009088 threonine biosynthetic process(GO:0009088)
0.1 0.1 GO:0010452 histone H3-K36 methylation(GO:0010452)
0.1 0.5 GO:0006998 nuclear envelope organization(GO:0006998)
0.1 0.6 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1 0.4 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 2.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 0.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.2 GO:0001927 exocyst assembly(GO:0001927)
0.1 2.2 GO:0006334 nucleosome assembly(GO:0006334)
0.1 0.4 GO:0055075 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.1 0.9 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.7 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.2 GO:0032886 regulation of microtubule-based process(GO:0032886) regulation of microtubule cytoskeleton organization(GO:0070507)
0.1 0.2 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.1 0.2 GO:0008216 spermidine metabolic process(GO:0008216)
0.1 0.1 GO:0043038 amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)
0.1 0.3 GO:0008272 sulfate transport(GO:0008272)
0.1 1.3 GO:0008219 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.1 0.1 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.1 1.2 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.2 GO:0045833 negative regulation of lipid metabolic process(GO:0045833)
0.1 0.9 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.5 GO:0000011 vacuole inheritance(GO:0000011)
0.1 0.5 GO:0016125 steroid metabolic process(GO:0008202) sterol metabolic process(GO:0016125)
0.1 0.5 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.2 GO:0032042 mitochondrial DNA metabolic process(GO:0032042)
0.1 0.3 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.1 0.4 GO:0072337 modified amino acid transport(GO:0072337)
0.1 2.1 GO:0006887 exocytosis(GO:0006887)
0.1 0.4 GO:0006855 drug transmembrane transport(GO:0006855)
0.1 0.1 GO:0048211 Golgi vesicle docking(GO:0048211)
0.1 0.5 GO:0006857 oligopeptide transport(GO:0006857)
0.1 1.9 GO:0034470 ncRNA processing(GO:0034470)
0.1 0.5 GO:0006999 nuclear pore organization(GO:0006999)
0.1 0.1 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.1 0.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.3 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.1 0.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.7 GO:0006414 translational elongation(GO:0006414)
0.1 0.2 GO:0031338 regulation of vesicle fusion(GO:0031338) SNARE complex assembly(GO:0035493) regulation of SNARE complex assembly(GO:0035542)
0.1 0.1 GO:0008299 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.1 0.2 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 1.2 GO:0009303 rRNA transcription(GO:0009303)
0.1 0.5 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.3 GO:0006284 base-excision repair(GO:0006284)
0.0 0.2 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.0 0.5 GO:0051666 actin cortical patch localization(GO:0051666)
0.0 0.1 GO:0030308 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.0 0.3 GO:0045047 protein targeting to ER(GO:0045047)
0.0 0.0 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.3 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.0 0.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.1 GO:0015867 ATP transport(GO:0015867)
0.0 0.3 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.2 GO:0008655 pyrimidine-containing compound salvage(GO:0008655)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.2 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.0 0.1 GO:0001173 DNA-templated transcriptional start site selection(GO:0001173) transcriptional start site selection at RNA polymerase II promoter(GO:0001174)
0.0 0.2 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0 0.2 GO:0010921 regulation of phosphatase activity(GO:0010921) regulation of protein dephosphorylation(GO:0035304)
0.0 0.3 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.4 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.6 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.1 GO:0043173 nucleotide salvage(GO:0043173)
0.0 0.4 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.1 GO:0050821 protein stabilization(GO:0050821)
0.0 1.1 GO:0006839 mitochondrial transport(GO:0006839)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) negative regulation of proteasomal protein catabolic process(GO:1901799)
0.0 0.3 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.1 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.0 1.2 GO:0006457 protein folding(GO:0006457)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 0.1 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.0 0.0 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.1 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.0 GO:0031081 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.0 0.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.1 GO:0031023 microtubule organizing center organization(GO:0031023) spindle pole body organization(GO:0051300)
0.0 0.0 GO:0051865 protein autoubiquitination(GO:0051865)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.5 7.5 GO:0000408 EKC/KEOPS complex(GO:0000408)
1.1 7.5 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
1.1 3.2 GO:0070545 PeBoW complex(GO:0070545)
1.0 4.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.8 2.5 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.8 3.1 GO:0044697 HICS complex(GO:0044697)
0.6 4.4 GO:0016459 myosin complex(GO:0016459)
0.6 2.9 GO:0030689 Noc complex(GO:0030689)
0.6 2.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.6 2.8 GO:0031389 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.5 3.3 GO:0042555 MCM complex(GO:0042555)
0.5 2.1 GO:0031518 CBF3 complex(GO:0031518)
0.5 2.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.5 32.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 8.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 1.0 GO:0033553 rDNA heterochromatin(GO:0033553)
0.5 1.4 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.5 3.7 GO:0042597 periplasmic space(GO:0042597)
0.5 10.5 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.4 2.6 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.4 4.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.4 42.6 GO:0022626 cytosolic ribosome(GO:0022626)
0.4 1.7 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.4 2.0 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.4 2.3 GO:0032040 small-subunit processome(GO:0032040)
0.4 6.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.4 1.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.4 0.4 GO:0000133 polarisome(GO:0000133)
0.4 2.2 GO:0032126 eisosome(GO:0032126)
0.4 1.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.4 1.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.4 2.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.3 1.3 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.3 1.3 GO:0032160 septin filament array(GO:0032160)
0.3 1.3 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.3 2.2 GO:0000346 transcription export complex(GO:0000346)
0.3 1.6 GO:0032545 CURI complex(GO:0032545)
0.3 3.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.3 1.8 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.3 2.4 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.3 0.9 GO:0000137 Golgi cis cisterna(GO:0000137)
0.3 1.4 GO:0034518 RNA cap binding complex(GO:0034518)
0.3 1.1 GO:0000817 COMA complex(GO:0000817)
0.3 2.4 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.3 0.8 GO:0043529 GET complex(GO:0043529)
0.2 0.7 GO:0000131 incipient cellular bud site(GO:0000131)
0.2 0.7 GO:0031417 NatC complex(GO:0031417)
0.2 1.0 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 1.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 1.8 GO:0000142 cellular bud neck contractile ring(GO:0000142)
0.2 2.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 0.6 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 0.4 GO:0048475 membrane coat(GO:0030117) clathrin adaptor complex(GO:0030131) coated membrane(GO:0048475)
0.2 3.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 1.2 GO:0005871 kinesin complex(GO:0005871)
0.2 0.8 GO:0030907 MBF transcription complex(GO:0030907)
0.2 1.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 6.9 GO:0005811 lipid particle(GO:0005811)
0.2 0.7 GO:0005797 Golgi medial cisterna(GO:0005797)
0.2 1.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 0.9 GO:0034044 exomer complex(GO:0034044)
0.2 0.5 GO:0030428 cell septum(GO:0030428)
0.2 8.7 GO:0030686 90S preribosome(GO:0030686)
0.2 0.7 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 1.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 0.5 GO:0000814 ESCRT II complex(GO:0000814)
0.2 0.5 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 1.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.0 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 0.9 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.9 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 0.7 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 0.3 GO:0000786 nucleosome(GO:0000786)
0.1 1.4 GO:0005940 septin ring(GO:0005940)
0.1 0.8 GO:0070772 PAS complex(GO:0070772)
0.1 0.5 GO:0005884 actin filament(GO:0005884)
0.1 0.6 GO:0043614 multi-eIF complex(GO:0043614)
0.1 4.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.4 GO:0005771 multivesicular body(GO:0005771)
0.1 1.2 GO:0042729 DASH complex(GO:0042729)
0.1 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 1.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.6 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.1 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 3.1 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 17.3 GO:0005933 cellular bud(GO:0005933)
0.1 0.1 GO:0030286 dynactin complex(GO:0005869) dynein complex(GO:0030286)
0.1 0.4 GO:0000938 GARP complex(GO:0000938)
0.1 2.9 GO:0012506 vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659)
0.1 0.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.2 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.1 0.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.4 GO:0031262 Ndc80 complex(GO:0031262)
0.1 2.6 GO:0071010 U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.1 1.6 GO:0016586 RSC complex(GO:0016586)
0.1 3.6 GO:0005816 microtubule organizing center(GO:0005815) spindle pole body(GO:0005816)
0.1 0.6 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 0.2 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.1 0.3 GO:0070823 HDA1 complex(GO:0070823)
0.1 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.1 0.8 GO:0034399 nuclear periphery(GO:0034399)
0.1 1.9 GO:0005844 polysome(GO:0005844)
0.1 1.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.5 GO:0030894 alpha DNA polymerase:primase complex(GO:0005658) replisome(GO:0030894) nuclear replisome(GO:0043601)
0.1 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.6 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.2 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.2 GO:0070939 Dsl1p complex(GO:0070939)
0.1 1.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 6.1 GO:0005730 nucleolus(GO:0005730)
0.1 0.2 GO:0000262 cytoplasmic chromosome(GO:0000229) mitochondrial chromosome(GO:0000262)
0.1 2.3 GO:0000139 Golgi membrane(GO:0000139)
0.1 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.3 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.1 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.2 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.2 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.5 GO:0031298 replication fork protection complex(GO:0031298)
0.1 0.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.6 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0055087 Ski complex(GO:0055087)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0033263 HOPS complex(GO:0030897) CORVET complex(GO:0033263)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.2 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 1.0 GO:0005840 ribosome(GO:0005840)
0.0 1.1 GO:0043332 mating projection tip(GO:0043332)
0.0 0.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0044815 DNA packaging complex(GO:0044815)
0.0 0.1 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.4 GO:0031201 SNARE complex(GO:0031201)
0.0 5.8 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.1 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.0 0.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.1 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.0 0.1 GO:0045254 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 2.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.0 0.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.0 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 15.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
2.4 7.1 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
2.0 12.1 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.7 6.8 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.6 6.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.4 4.3 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
1.4 5.5 GO:0016841 ammonia-lyase activity(GO:0016841)
1.3 4.0 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
1.3 5.0 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
1.1 3.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
1.1 6.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.9 3.6 GO:0004497 monooxygenase activity(GO:0004497)
0.9 4.4 GO:0000146 microfilament motor activity(GO:0000146)
0.9 3.5 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.9 3.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.8 4.8 GO:0016408 C-acyltransferase activity(GO:0016408)
0.8 7.6 GO:0005216 ion channel activity(GO:0005216)
0.7 3.0 GO:0009378 four-way junction helicase activity(GO:0009378)
0.7 2.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.7 10.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.7 2.2 GO:0016872 intramolecular lyase activity(GO:0016872)
0.7 2.9 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.7 7.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.7 3.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.7 2.0 GO:0004100 chitin synthase activity(GO:0004100)
0.6 14.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.6 1.8 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.6 1.7 GO:0016504 peptidase activator activity(GO:0016504)
0.6 2.3 GO:0004771 sterol esterase activity(GO:0004771)
0.6 1.7 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.6 2.8 GO:0004707 MAP kinase activity(GO:0004707)
0.6 1.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.5 1.6 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.5 1.6 GO:0043812 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.5 1.6 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.5 2.6 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.5 2.4 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.5 1.4 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.5 2.8 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.5 1.4 GO:0000339 RNA cap binding(GO:0000339)
0.4 1.3 GO:0009922 fatty acid elongase activity(GO:0009922)
0.4 1.7 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.4 5.0 GO:0005199 structural constituent of cell wall(GO:0005199)
0.4 1.6 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.4 1.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.4 2.7 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.4 6.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.4 1.9 GO:0019201 nucleotide kinase activity(GO:0019201)
0.4 1.1 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.4 3.6 GO:0031386 protein tag(GO:0031386)
0.4 2.9 GO:0019237 centromeric DNA binding(GO:0019237)
0.4 1.1 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.4 1.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.3 1.3 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.3 1.0 GO:0070568 guanylyltransferase activity(GO:0070568)
0.3 1.2 GO:0008242 omega peptidase activity(GO:0008242)
0.3 1.5 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.3 12.3 GO:0030674 protein binding, bridging(GO:0030674)
0.3 5.7 GO:0042162 telomeric DNA binding(GO:0042162)
0.3 0.3 GO:0019003 GDP binding(GO:0019003)
0.3 0.9 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.3 0.3 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.3 0.9 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.3 0.8 GO:0019202 amino acid kinase activity(GO:0019202)
0.3 55.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 0.5 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.2 0.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 0.5 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2 0.9 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.2 2.4 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.2 2.3 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.2 0.7 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 1.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.2 1.9 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.2 7.3 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 1.4 GO:0051015 actin filament binding(GO:0051015)
0.2 0.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 0.8 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.2 0.2 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.2 0.6 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 1.1 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.2 1.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 2.6 GO:0001671 ATPase activator activity(GO:0001671)
0.2 0.6 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.2 0.7 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 3.5 GO:0005048 signal sequence binding(GO:0005048)
0.2 0.7 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 1.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 0.5 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.2 0.9 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.2 1.8 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.2 6.3 GO:0051536 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.2 0.9 GO:0008443 phosphofructokinase activity(GO:0008443)
0.2 2.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.2 0.7 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 1.0 GO:0016778 diphosphotransferase activity(GO:0016778)
0.2 1.3 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 1.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 0.8 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.2 8.8 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.2 1.4 GO:0019904 protein domain specific binding(GO:0019904)
0.2 2.2 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 1.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.2 0.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 0.6 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.2 0.9 GO:0051087 chaperone binding(GO:0051087)
0.2 0.8 GO:0030145 manganese ion binding(GO:0030145)
0.1 0.4 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 1.2 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 1.2 GO:0005516 calmodulin binding(GO:0005516)
0.1 1.4 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 1.4 GO:0019239 deaminase activity(GO:0019239)
0.1 1.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.4 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 1.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 3.7 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.1 4.0 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.8 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.1 1.2 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.1 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 0.4 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.1 0.7 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 6.8 GO:0003924 GTPase activity(GO:0003924)
0.1 0.5 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.1 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.8 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 0.3 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 1.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 0.3 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 0.2 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 1.1 GO:0000182 rDNA binding(GO:0000182)
0.1 0.3 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 2.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.3 GO:0019901 protein kinase binding(GO:0019901)
0.1 0.9 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 4.2 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 0.6 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 2.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.0 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 2.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.3 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.1 0.7 GO:0019843 rRNA binding(GO:0019843)
0.1 0.6 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.5 GO:0030276 clathrin binding(GO:0030276)
0.1 3.6 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.1 0.5 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.1 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.6 GO:0017069 snRNA binding(GO:0017069)
0.1 2.4 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 0.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 0.5 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.1 0.3 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.1 0.6 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.1 0.2 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.1 0.5 GO:0003724 RNA helicase activity(GO:0003724)
0.1 0.7 GO:0019207 kinase regulator activity(GO:0019207)
0.1 1.8 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 0.7 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.3 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 1.1 GO:0005525 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.1 1.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.1 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295)
0.1 0.1 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.1 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.1 GO:0000403 Y-form DNA binding(GO:0000403)
0.1 0.4 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.1 0.4 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.2 GO:0042277 peptide binding(GO:0042277)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 2.0 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors(GO:0016614)
0.0 0.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 2.3 GO:0016791 phosphatase activity(GO:0016791)
0.0 0.7 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.2 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 0.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.3 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0 0.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.2 GO:0043022 ribosome binding(GO:0043022)
0.0 0.2 GO:0000149 SNARE binding(GO:0000149)
0.0 4.5 GO:0003723 RNA binding(GO:0003723)
0.0 0.2 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.0 0.2 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.0 0.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.6 5.6 PID ATR PATHWAY ATR signaling pathway
0.4 0.9 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.4 0.4 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.4 1.9 PID PLK1 PATHWAY PLK1 signaling events
0.3 0.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.2 0.6 PID E2F PATHWAY E2F transcription factor network
0.2 0.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 0.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.7 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.1 0.4 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.1 0.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.2 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.9 1.8 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.7 2.8 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.5 3.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.5 1.0 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.5 1.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.4 3.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4 1.4 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.3 1.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.3 6.2 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.3 0.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.2 0.2 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.2 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 1.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 2.5 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.1 0.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.6 REACTOME DEADENYLATION DEPENDENT MRNA DECAY Genes involved in Deadenylation-dependent mRNA decay
0.1 0.5 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.1 0.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.2 REACTOME AXON GUIDANCE Genes involved in Axon guidance
0.0 0.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.2 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling