Results for RPH1
Z-value: 3.74
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Transcription factors associated with RPH1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RPH1
|
S000000971 | JmjC domain-containing histone demethylase |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YMR107W Show fit | 57.85 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YHR096C Show fit | 54.27 |
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs |
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| YBR072W Show fit | 53.23 |
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells |
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| YMR175W Show fit | 48.90 |
Protein of unknown function whose expression is induced by osmotic stress |
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| YGR087C Show fit | 47.02 |
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation |
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| YNR034W-A Show fit | 41.20 |
Putative protein of unknown function; expression is regulated by Msn2p/Msn4p |
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| YKL065W-A Show fit | 40.50 |
Putative protein of unknown function |
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| YGR256W Show fit | 34.05 |
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone |
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| YFR017C Show fit | 33.78 |
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene |
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| YHR139C Show fit | 32.91 |
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall |
Network of associatons between targets according to the STRING database.
First level regulatory network of RPH1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.3 | 91.1 | GO:0015758 | glucose transport(GO:0015758) |
| 12.6 | 50.4 | GO:0006848 | pyruvate transport(GO:0006848) |
| 12.1 | 48.6 | GO:0009415 | response to water(GO:0009415) cellular response to water stimulus(GO:0071462) |
| 12.1 | 48.3 | GO:0000949 | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949) |
| 5.7 | 45.3 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 2.8 | 44.7 | GO:0006754 | ATP biosynthetic process(GO:0006754) |
| 4.6 | 41.5 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
| 8.1 | 40.7 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
| 2.5 | 40.7 | GO:0042724 | thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724) |
| 1.0 | 40.2 | GO:0071940 | ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 323.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.5 | 64.2 | GO:0000323 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 2.8 | 36.8 | GO:0005619 | ascospore wall(GO:0005619) |
| 2.9 | 35.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 1.9 | 33.8 | GO:0031306 | intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307) |
| 10.9 | 32.7 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 6.2 | 30.9 | GO:0045257 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 2.2 | 27.0 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259) |
| 1.1 | 23.8 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.5 | 23.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 121.4 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 4.7 | 65.4 | GO:0005353 | fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578) |
| 3.0 | 51.7 | GO:0046906 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
| 9.9 | 49.4 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 12.1 | 48.3 | GO:0004737 | pyruvate decarboxylase activity(GO:0004737) |
| 10.9 | 32.7 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 10.8 | 32.3 | GO:0016880 | acid-ammonia (or amide) ligase activity(GO:0016880) |
| 5.3 | 32.0 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 4.0 | 31.8 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 6.2 | 30.9 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 453.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 3.1 | 15.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 3.5 | 10.6 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 1.8 | 7.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.1 | 3.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.7 | 2.1 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.7 | 2.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.7 | 2.0 | PID FOXO PATHWAY | FoxO family signaling |
| 0.3 | 1.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 0.8 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 453.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 3.0 | 33.5 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 8.7 | 26.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.4 | 5.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.9 | 3.4 | REACTOME BIOLOGICAL OXIDATIONS | Genes involved in Biological oxidations |
| 0.9 | 2.7 | REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | Genes involved in MyD88:Mal cascade initiated on plasma membrane |
| 1.3 | 2.6 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.5 | 1.4 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.5 | 1.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 1.4 | REACTOME MEIOSIS | Genes involved in Meiosis |