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Results for RSC30

Z-value: 0.67

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Transcription factors associated with RSC30

Gene Symbol Gene ID Gene Info
RSC30
S000001098 Component of the RSC chromatin remodeling complex

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RSC30YHR056C0.544.0e-03Click!

Activity profile of RSC30 motif

Sorted Z-values of RSC30 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YOR348C 6.74
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YIL057C 3.52 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YGR067C 3.22 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YJR115W 2.69 Putative protein of unknown function
YOR345C 2.69 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YKL109W 2.68
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YML089C 2.63 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YGL062W 2.58
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YPL026C 2.55
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YOR346W 2.53
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YKL031W 2.48 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YOR072W 2.41 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YPL024W 2.31
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YAR050W 2.29
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YPR036W-A 2.18 Protein of unknown function; transcription is regulated by Pdr1p
YER065C 2.10
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YOR071C 2.00
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YJL045W 1.96 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YER088C 1.95
DOT6
Protein of unknown function, involved in telomeric gene silencing and filamentation
YLR296W 1.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR150W 1.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YDL222C 1.77
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YOR072W-A 1.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YJR078W 1.74
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YCR005C 1.73
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YBR105C 1.70
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YML090W 1.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YAR047C 1.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR152C 1.64 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YER150W 1.63
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YBL015W 1.63
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YDR343C 1.53
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YJL067W 1.52 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAR035W 1.47
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YDL210W 1.45
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YJR095W 1.44
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YPR065W 1.43
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YOR192C 1.39
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YMR194C-B 1.38 Putative protein of unknown function
YOR120W 1.36
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YLR295C 1.35
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YFL030W 1.35
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YML091C 1.33
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YBR297W 1.32
MAL33
MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YOL084W 1.31
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YLR236C 1.29 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR033C 1.27
QCR6
Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YPL230W 1.26
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YBR201C-A 1.25 Putative protein of unknown function
YAR023C 1.25 Putative integral membrane protein, member of DUP240 gene family
YMR103C 1.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL305C 1.25 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YBL033C 1.21
RIB1
GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YPL061W 1.20
ALD6
Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YHR139C 1.17
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YLR235C 1.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3
YGL045W 1.17
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YOL060C 1.17
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YLR377C 1.15
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YMR195W 1.15
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YOR139C 1.15 Hypothetical protein
YAL039C 1.14
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YKL032C 1.12
IXR1
Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YDR277C 1.11
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YKL171W 1.11 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YFR029W 1.10
PTR3
Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YIL099W 1.08
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YAR070C 1.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR259C 1.07
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YFL024C 1.07
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YPR127W 1.07 Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YHR033W 1.07 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YIL125W 1.04
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YDL067C 1.04
COX9
Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YOR186C-A 1.03 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YOL085W-A 1.01 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YPL250C 1.01
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YDR377W 1.00
ATP17
Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YCR025C 1.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YPL262W 0.99
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YMR181C 0.98 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YOR192C-C 0.98 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YPR013C 0.97 Putative zinc finger protein; YPR013C is not an essential gene
YNR073C 0.97 Putative mannitol dehydrogenase
YOR140W 0.96
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YBL064C 0.95
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YNL091W 0.92
NST1
Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
YLR438W 0.91
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YGL177W 0.88 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAR069C 0.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR048W 0.87
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YOR235W 0.86
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YMR306C-A 0.86 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR176W 0.85
FMO1
Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
YPR192W 0.85
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YDR043C 0.84
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YIL101C 0.83
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YKL163W 0.82
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YKL085W 0.82
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YLR054C 0.81
OSW2
Protein of unknown function proposed to be involved in the assembly of the spore wall
YDR169C 0.81
STB3
Protein that binds Sin3p in a two-hybrid assay
YHR211W 0.81
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YEL049W 0.81
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDR119W-A 0.79 Putative protein of unknown function
YFL064C 0.79 Putative protein of unknown function
YLR297W 0.79 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YKL217W 0.78
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YDL181W 0.76
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YFR034C 0.76
PHO4
Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability
YJR077C 0.76
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YMR135C 0.75
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YNL033W 0.74 Putative protein of unknown function
YLR437C-A 0.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YOR338W 0.74 Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen
YPL058C 0.72
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YLR237W 0.72
THI7
Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YIL055C 0.71 Putative protein of unknown function
YBR240C 0.70
THI2
Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes
YCL025C 0.70
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YFL059W 0.69
SNZ3
Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3
YGR258C 0.69
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YPL025C 0.69 Hypothetical protein
YLR176C 0.69
RFX1
Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
YMR017W 0.69
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YDR242W 0.68
AMD2
Putative amidase
YIR027C 0.68
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YOR138C 0.68
RUP1
Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain
YDR452W 0.67
PPN1
Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
YPR054W 0.67
SMK1
Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
YGL146C 0.67 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YDR466W 0.67
PKH3
Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
YBR284W 0.66 Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YOR394W 0.66
PAU21
Hypothetical protein
YHR015W 0.66
MIP6
Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YNL104C 0.65
LEU4
Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YGL117W 0.65 Putative protein of unknown function
YGR121C 0.64
MEP1
Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YIL155C 0.64
GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YPL015C 0.63
HST2
Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YOR344C 0.63
TYE7
Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
YPL164C 0.63
MLH3
Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
YIL100C-A 0.62 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR034W-A 0.62 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YFR035C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YJL100W 0.62
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YPL282C 0.61
PAU22
Hypothetical protein
YDR231C 0.61
COX20
Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YNL103W 0.61
MET4
Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
YBR006W 0.61
UGA2
Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm
YNL125C 0.61
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YPL135W 0.60
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YDL174C 0.60
DLD1
D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YLR111W 0.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER069W 0.59
ARG5,6
Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p
YHR071W 0.59
PCL5
Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YKR097W 0.58
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YDL007C-A 0.58 Putative protein of unknown function
YFR012W 0.58 Putative protein of unknown function
YDL221W 0.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
YNR047W 0.58 Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate
YNL283C 0.56
WSC2
Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YIL045W 0.56
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YJL103C 0.56
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YML133C 0.56 Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron
YLR399C 0.55
BDF1
Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
YMR069W 0.55
NAT4
N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A
YNL019C 0.55 Putative protein of unknown function
YPR005C 0.54
HAL1
Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YMR063W 0.53
RIM9
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein
YIL100W 0.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YFL060C 0.53
SNO3
Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin
YEL033W 0.53
MTC7
Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YBR001C 0.52
NTH2
Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses
YJL116C 0.51
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YOR032C 0.50
HMS1
Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YKR095W 0.49
MLP1
Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
YJL005W 0.49
CYR1
Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YHR145C 0.49 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL243W 0.49
SLA2
Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo
YBL084C 0.49
CDC27
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YER068C-A 0.49 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL063W 0.49 Dubious open reading frame, based on available experimental and comparative sequence data
YNL282W 0.49
POP3
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YKL161C 0.48 Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YMR306W 0.47
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL028W 0.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL014W 0.47
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YGR144W 0.47
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YOR374W 0.47
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YBR077C 0.46
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YJL102W 0.46
MEF2
Mitochondrial elongation factor involved in translational elongation
YBR035C 0.46
PDX3
Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YEL009C 0.46
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YNL245C 0.45
CWC25
Component of a complex containing Cef1p, involved in pre-mRNA splicing; has similarity to S. pombe Cwf25p
YKR067W 0.44
GPT2
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YLR140W 0.44 Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
YPL054W 0.43
LEE1
Zinc-finger protein of unknown function
YBR179C 0.43
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YOR236W 0.43
DFR1
Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function
YBL100C 0.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YOR285W 0.42 Protein of unknown function, localized to the mitochondrial outer membrane

Network of associatons between targets according to the STRING database.

First level regulatory network of RSC30

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.8 GO:0015804 neutral amino acid transport(GO:0015804)
1.4 4.1 GO:0015888 thiamine transport(GO:0015888)
0.6 1.8 GO:0006545 glycine biosynthetic process(GO:0006545)
0.6 1.8 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.6 2.4 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.6 1.7 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.6 1.7 GO:0019413 acetate biosynthetic process(GO:0019413)
0.5 3.0 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.5 1.5 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.5 1.4 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.5 1.4 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.5 1.4 GO:0042843 D-xylose catabolic process(GO:0042843)
0.4 3.9 GO:0006097 glyoxylate cycle(GO:0006097)
0.4 2.6 GO:0043457 regulation of cellular respiration(GO:0043457)
0.4 1.6 GO:0006083 acetate metabolic process(GO:0006083)
0.4 1.1 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.3 1.7 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.3 0.6 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.3 0.9 GO:0005993 trehalose catabolic process(GO:0005993)
0.3 0.3 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
0.3 0.6 GO:0006538 glutamate catabolic process(GO:0006538)
0.3 0.9 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.3 3.3 GO:0015758 glucose transport(GO:0015758)
0.3 1.2 GO:0015847 putrescine transport(GO:0015847)
0.3 2.5 GO:0070987 error-free translesion synthesis(GO:0070987)
0.3 1.1 GO:0071456 cellular response to hypoxia(GO:0071456)
0.3 1.1 GO:0043200 response to amino acid(GO:0043200)
0.3 1.0 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.3 1.0 GO:0006848 pyruvate transport(GO:0006848)
0.3 0.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 2.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.2 1.2 GO:0005980 glycogen catabolic process(GO:0005980)
0.2 0.7 GO:0030656 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of sulfur metabolic process(GO:0051176) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.2 0.9 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.2 0.7 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.2 0.7 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.2 1.3 GO:0042407 cristae formation(GO:0042407)
0.2 0.6 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.2 0.6 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.2 0.6 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.2 0.2 GO:0044109 cellular alcohol catabolic process(GO:0044109)
0.2 0.8 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.2 1.3 GO:0000023 maltose metabolic process(GO:0000023)
0.2 0.6 GO:0006119 oxidative phosphorylation(GO:0006119)
0.2 0.5 GO:0006108 malate metabolic process(GO:0006108)
0.2 1.4 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.2 0.7 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.2 2.1 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.2 1.2 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.2 1.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.2 1.2 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.2 0.8 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187) adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
0.2 1.0 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.2 0.2 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.2 1.1 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.1 1.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.6 GO:0016241 regulation of macroautophagy(GO:0016241) negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108) negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 1.7 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.7 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 1.1 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.6 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.1 0.5 GO:0015886 heme transport(GO:0015886)
0.1 0.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.4 GO:0015856 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.1 0.6 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.1 0.5 GO:0072414 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.1 1.3 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 2.2 GO:0006094 gluconeogenesis(GO:0006094)
0.1 1.0 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.1 0.6 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.4 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.7 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.1 0.3 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 1.5 GO:0009651 response to salt stress(GO:0009651)
0.1 0.2 GO:0046688 response to copper ion(GO:0046688)
0.1 0.3 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.1 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.6 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 0.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.2 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.6 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.1 0.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 1.0 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.1 1.7 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.1 GO:0043270 positive regulation of ion transport(GO:0043270)
0.1 2.3 GO:0070591 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.2 GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress(GO:0061408)
0.1 1.0 GO:0001101 response to acid chemical(GO:0001101)
0.1 0.2 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.1 0.2 GO:0042744 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.1 0.5 GO:0034965 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.1 0.3 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.2 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.1 1.1 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 0.1 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.5 GO:0051181 cofactor transport(GO:0051181)
0.0 0.6 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.0 0.6 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.5 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.3 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.6 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.0 0.3 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 0.8 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.2 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322)
0.0 0.2 GO:0032845 negative regulation of telomere maintenance(GO:0032205) negative regulation of homeostatic process(GO:0032845)
0.0 0.4 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.3 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.1 GO:0006086 acetyl-CoA biosynthetic process(GO:0006085) acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.4 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.1 GO:0050810 regulation of steroid metabolic process(GO:0019218) regulation of ergosterol biosynthetic process(GO:0032443) regulation of steroid biosynthetic process(GO:0050810)
0.0 0.1 GO:0071248 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to metal ion(GO:0071248) cellular response to iron ion(GO:0071281)
0.0 0.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0048211 Golgi vesicle docking(GO:0048211)
0.0 0.2 GO:0006279 premeiotic DNA replication(GO:0006279)
0.0 0.2 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.0 0.9 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.1 GO:0006813 potassium ion transport(GO:0006813)
0.0 0.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.0 0.2 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.0 GO:0045913 positive regulation of cellular carbohydrate metabolic process(GO:0010676) positive regulation of carbohydrate metabolic process(GO:0045913)
0.0 0.2 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.2 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.2 GO:0070058 tRNA gene clustering(GO:0070058)
0.0 0.5 GO:1902534 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.0 0.1 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.2 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.0 0.1 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.0 0.3 GO:0034401 chromatin organization involved in regulation of transcription(GO:0034401)
0.0 0.1 GO:0009098 leucine biosynthetic process(GO:0009098)
0.0 0.1 GO:0006816 calcium ion transport(GO:0006816)
0.0 0.7 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.4 GO:0098660 inorganic ion transmembrane transport(GO:0098660)
0.0 0.1 GO:0042435 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.4 GO:0006184 obsolete GTP catabolic process(GO:0006184)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.0 GO:0051180 vitamin transport(GO:0051180)
0.0 0.5 GO:0016573 histone acetylation(GO:0016573)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.0 0.2 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.1 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.3 GO:0009408 response to heat(GO:0009408)
0.0 0.1 GO:0032258 CVT pathway(GO:0032258)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.7 2.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 2.8 GO:0034657 GID complex(GO:0034657)
0.3 1.0 GO:0045240 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.3 1.0 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.3 2.4 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.2 1.9 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.2 1.6 GO:0042597 periplasmic space(GO:0042597)
0.2 1.8 GO:0030677 ribonuclease P complex(GO:0030677)
0.2 1.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 1.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 1.8 GO:0033698 Rpd3L complex(GO:0033698)
0.1 0.5 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 2.1 GO:0070469 respiratory chain(GO:0070469)
0.1 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.7 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.1 1.2 GO:0005619 ascospore wall(GO:0005619)
0.1 0.5 GO:0034448 EGO complex(GO:0034448)
0.1 1.6 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 1.3 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 1.9 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.6 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.2 GO:0005784 Sec61 translocon complex(GO:0005784)
0.0 0.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 7.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.2 GO:0033309 SBF transcription complex(GO:0033309)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.2 GO:0070772 PAS complex(GO:0070772)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.0 0.4 GO:0005769 early endosome(GO:0005769)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0043614 multi-eIF complex(GO:0043614)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 3.1 GO:0098852 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.0 0.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.0 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.0 0.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.1 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 2.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.1 GO:0097346 INO80-type complex(GO:0097346)
0.0 0.1 GO:0031933 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.0 0.7 GO:0005643 nuclear pore(GO:0005643)
0.0 0.1 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.8 3.1 GO:0005537 mannose binding(GO:0005537)
0.6 1.9 GO:0016289 CoA hydrolase activity(GO:0016289)
0.6 1.7 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.5 5.0 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.5 1.5 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.5 1.4 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.4 2.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.4 1.4 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.3 1.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 1.0 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.3 0.9 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.3 2.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.3 1.2 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.3 1.7 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 1.0 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.2 2.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 1.2 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.2 1.7 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 0.9 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.2 1.7 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 1.8 GO:0004526 ribonuclease P activity(GO:0004526)
0.2 0.5 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.2 0.7 GO:0015295 solute:proton symporter activity(GO:0015295)
0.2 1.2 GO:0019238 cyclohydrolase activity(GO:0019238)
0.2 0.8 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 0.5 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.2 3.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 0.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 1.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.3 GO:0000150 recombinase activity(GO:0000150)
0.1 0.6 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 3.6 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 0.7 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 0.5 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.1 0.6 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.6 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 1.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.5 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.5 GO:0008198 ferrous iron binding(GO:0008198)
0.1 1.0 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 1.8 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.3 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.1 GO:0016898 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.1 0.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.6 GO:0015293 symporter activity(GO:0015293)
0.1 0.7 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.5 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.8 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.5 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 0.8 GO:0038023 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.1 1.7 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 0.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.5 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 0.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.3 GO:0015081 sodium ion transmembrane transporter activity(GO:0015081)
0.1 0.4 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0 0.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.1 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.0 0.8 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.2 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 0.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.0 0.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.2 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 3.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.4 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.2 GO:0004601 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.0 0.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.1 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.2 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.0 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.0 0.0 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.5 0.5 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.3 0.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.3 2.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 0.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 0.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 0.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 29.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.0 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.3 0.8 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.2 2.7 REACTOME DNA REPAIR Genes involved in DNA Repair
0.2 0.9 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.2 1.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.5 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 0.6 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.1 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.2 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.0 29.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling