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Results for RTG3

Z-value: 0.68

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Transcription factors associated with RTG3

Gene Symbol Gene ID Gene Info
RTG3
S000000199 Transcription factor for retrograde (RTG) and TOR pathways

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RTG3YBL103C0.271.8e-01Click!

Activity profile of RTG3 motif

Sorted Z-values of RTG3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YPL250C 10.85
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YJL133C-A 7.87 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHL036W 5.78
MUP3
Low affinity methionine permease, similar to Mup1p
YAL054C 4.88
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YCL040W 4.65
GLK1
Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YCL042W 4.44 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YJR095W 4.17
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YKL016C 4.13
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YAL062W 3.94
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YML120C 3.75
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YNL036W 3.72
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YOR348C 3.58
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YJR138W 3.57
IML1
Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YJR146W 3.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YJR137C 3.32
ECM17
Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YPL024W 3.31
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YMR081C 3.24
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YNL063W 2.94
MTQ1
S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene
YIL107C 2.90
PFK26
6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A
YMR271C 2.76
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YPL018W 2.70
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YMR194C-B 2.55 Putative protein of unknown function
YAR053W 2.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL116C 2.52
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YMR013C 2.49
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YPL026C 2.49
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YHR001W-A 2.38
QCR10
Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YJR150C 2.37
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YJL045W 2.35 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YER091C-A 2.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR065C 2.31
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YPR001W 2.29
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YFL024C 2.27
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YNL104C 2.25
LEU4
Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YJL166W 2.23
QCR8
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YHR033W 2.22 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YOR346W 2.20
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YOR152C 2.14 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YLR438W 2.10
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YML081C-A 2.02
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YLR092W 2.02
SUL2
High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
YMR017W 2.01
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YDR542W 2.01
PAU10
Hypothetical protein
YPR036W-A 2.01 Protein of unknown function; transcription is regulated by Pdr1p
YCL001W-B 1.99 Putative protein of unknown function; identified by homology
YEL024W 1.97
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YAR060C 1.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR149C 1.96 Putative protein of unknown function; YLR149C is not an essential gene
YDR055W 1.92
PST1
Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YKL085W 1.91
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YDR530C 1.91
APA2
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YNL037C 1.90
IDH1
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YOR345C 1.87 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YLR437C-A 1.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YMR306W 1.81
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL067C 1.81
COX9
Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YER065C 1.81
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YFR049W 1.74
YMR31
Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
YLR402W 1.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL045W 1.70
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YJR115W 1.70 Putative protein of unknown function
YPL189C-A 1.70
COA2
Putative cytochrome oxidase assembly factor; identified by homology to Ashbya gossypii; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity
YDR022C 1.68
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YDR169C 1.68
STB3
Protein that binds Sin3p in a two-hybrid assay
YBL078C 1.67
ATG8
Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YLR403W 1.67
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YDR381C-A 1.66 Protein of unknown function, localized to the mitochondrial outer membrane
YKL217W 1.65
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YAR050W 1.64
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YOR328W 1.64
PDR10
ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
YLL055W 1.62
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YCR005C 1.62
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YFR030W 1.61
MET10
Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide
YLL056C 1.59 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YDR504C 1.58
SPG3
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YIL162W 1.56
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YAL061W 1.54
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YMR165C 1.54
PAH1
Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
YOR065W 1.54
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YBR296C 1.53
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YDL085W 1.53
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YLR327C 1.52
TMA10
Protein of unknown function that associates with ribosomes
YHR082C 1.50
KSP1
Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
YLR304C 1.50
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YKL192C 1.48
ACP1
Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
YPL206C 1.46
PGC1
Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs
YOR072W-A 1.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YBR072W 1.45
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YOR072W 1.44 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YJR155W 1.43
AAD10
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YLR326W 1.40 Hypothetical protein
YOR289W 1.40 Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YKL086W 1.39
SRX1
Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes
YAR047C 1.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR541C 1.38 Putative dihydrokaempferol 4-reductase
YMR195W 1.38
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YFR053C 1.37
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YBL030C 1.34
PET9
Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
YNL055C 1.34
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YCR011C 1.33
ADP1
Putative ATP-dependent permease of the ABC transporter family of proteins
YDL210W 1.32
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YDR438W 1.30
THI74
Mitochondrial transporter repressible by thiamine
YBR255C-A 1.30 Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YDL113C 1.29
ATG20
Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
YLR136C 1.28
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YOR054C 1.28
VHS3
Functionally redundant (see also SIS2) inhibitory subunit of Ppz1p, a PP1c-related ser/thr protein phosphatase Z isoform; synthetically lethal with sis2; putative phosphopantothenoylcysteine decarboxylase involved in coenzyme A biosynthesis
YER187W 1.28 Putative protein of unknown function; induced in respiratory-deficient cells
YBR145W 1.27
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YPL223C 1.27
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YOR071C 1.26
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YBL064C 1.25
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YNL115C 1.24 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
YCL041C 1.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
YNL240C 1.23
NAR1
Nuclear architecture related protein; component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins; homologous to human Narf
YIL047C 1.22
SYG1
Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YEL044W 1.21
IES6
Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YPL025C 1.21 Hypothetical protein
YJR147W 1.20
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YOR120W 1.20
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YBR116C 1.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YBR250W 1.20
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YBR287W 1.19 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
YDR441C 1.17
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YMR253C 1.15 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
YPL058C 1.15
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YCR088W 1.14
ABP1
Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization
YCL054W 1.14
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YAL063C 1.14
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YPL236C 1.13 Putative protein kinase that exhibits Akr1p-dependent palmitoylation
YOL082W 1.13
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YOR376W 1.12 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YNL103W 1.11
MET4
Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
YDR034C 1.11
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YIR039C 1.10
YPS6
Putative GPI-anchored aspartic protease
YLR307C-A 1.09 Putative protein of unknown function
YGR110W 1.09 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YOR055W 1.09 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDR114C 1.09 Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
YOR298C-A 1.09
MBF1
Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
YCL035C 1.08
GRX1
Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage
YGL072C 1.06 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YNL014W 1.06
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YHL037C 1.04 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL116W 1.04
DMA2
Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma1p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr.
YDR171W 1.03
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YMR014W 1.03
BUD22
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YKL031W 1.03 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YML089C 1.02 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YOR378W 1.00 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YBR039W 1.00
ATP3
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YKL044W 1.00 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL100W 1.00
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YPL240C 0.99
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YIL033C 0.98
BCY1
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YDR115W 0.98 Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins
YPR196W 0.97 Putative maltose activator
YFL063W 0.97 Dubious open reading frame, based on available experimental and comparative sequence data
YNL180C 0.97
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YPL135W 0.96
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YNL277W 0.96
MET2
L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway
YGR045C 0.96 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL018C 0.95 Putative protein of unknown function
YKL109W 0.95
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YNL283C 0.95
WSC2
Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YJL127C-B 0.94 Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
YDR442W 0.93 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL039C 0.92
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YGR221C 0.91
TOS2
Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p
YFL064C 0.91 Putative protein of unknown function
YFL055W 0.90
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YKR102W 0.90
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YOR192C 0.90
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YMR251W 0.89
GTO3
Omega class glutathione transferase; putative cytosolic localization
YHR212C 0.88 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR069W 0.88
MET1
S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
YNL179C 0.88 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YOL081W 0.87
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YDL020C 0.86
RPN4
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
YLR410W 0.86
VIP1
Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of IP7 by Vip1p is important for phosphate signaling; likely involved in cortical actin cytoskeleton function, by analogy with S. pombe ortholog asp1
YNL094W 0.86
APP1
Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization
YBL015W 0.86
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YHR138C 0.86 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YPR054W 0.86
SMK1
Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
YDR178W 0.84
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YHR212W-A 0.84 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YOR192C-C 0.84 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YHR204W 0.84
MNL1
Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides
YFL062W 0.83
COS4
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YOR377W 0.83
ATF1
Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation
YMR196W 0.83 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
YLR375W 0.83
STP3
Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YFR026C 0.82 Putative protein of unknown function
YOR173W 0.82
DCS2
Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YAL017W 0.81
PSK1
One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
YOR121C 0.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
YER186C 0.80 Putative protein of unknown function
YJL052W 0.80
TDH1
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YPR151C 0.79
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YDR277C 0.79
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YDR528W 0.78
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A

Network of associatons between targets according to the STRING database.

First level regulatory network of RTG3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.5 GO:0046323 glucose import(GO:0046323)
1.4 4.2 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.3 5.1 GO:0015804 neutral amino acid transport(GO:0015804)
1.3 3.8 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
1.0 2.0 GO:0008272 sulfate transport(GO:0008272)
0.9 1.9 GO:0006102 isocitrate metabolic process(GO:0006102)
0.9 3.8 GO:0043388 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.9 3.7 GO:0015976 carbon utilization(GO:0015976)
0.8 8.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.8 2.5 GO:0006003 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.8 4.9 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.8 4.7 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.8 2.3 GO:0015888 thiamine transport(GO:0015888)
0.8 2.3 GO:0019629 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.7 0.7 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.6 2.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.6 14.0 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.6 2.3 GO:0006527 arginine catabolic process(GO:0006527)
0.5 3.1 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.5 7.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.5 1.5 GO:0042843 D-xylose catabolic process(GO:0042843)
0.5 2.0 GO:0006108 malate metabolic process(GO:0006108)
0.5 1.5 GO:0009106 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.5 1.4 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.5 3.8 GO:0006097 glyoxylate cycle(GO:0006097)
0.5 1.4 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.5 1.4 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.4 3.1 GO:0015758 glucose transport(GO:0015758)
0.4 2.2 GO:0051180 vitamin transport(GO:0051180)
0.4 1.5 GO:0006848 pyruvate transport(GO:0006848)
0.4 1.1 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.4 3.9 GO:0016241 regulation of macroautophagy(GO:0016241)
0.3 0.3 GO:0045923 positive regulation of fatty acid metabolic process(GO:0045923)
0.3 3.0 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.3 1.3 GO:0015867 ATP transport(GO:0015867)
0.3 1.3 GO:0034389 lipid particle organization(GO:0034389)
0.3 1.6 GO:0046058 cAMP metabolic process(GO:0046058)
0.3 1.0 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.3 1.9 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.3 1.3 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.3 1.6 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.3 0.9 GO:0006545 glycine biosynthetic process(GO:0006545)
0.3 1.2 GO:0097271 protein localization to bud neck(GO:0097271)
0.3 0.9 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.3 0.3 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.3 2.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 0.9 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.3 1.4 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.3 3.9 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.3 1.9 GO:1902707 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.3 0.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.3 1.6 GO:0009098 leucine biosynthetic process(GO:0009098)
0.3 1.0 GO:0034030 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.3 0.8 GO:0006551 leucine metabolic process(GO:0006551)
0.2 0.5 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.2 2.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 2.8 GO:0046686 response to cadmium ion(GO:0046686)
0.2 0.7 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.2 0.2 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.2 1.5 GO:0006855 drug transmembrane transport(GO:0006855)
0.2 0.6 GO:0015856 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.2 0.8 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 1.0 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.2 3.4 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.2 1.0 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.2 0.2 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.2 0.2 GO:0019566 arabinose metabolic process(GO:0019566) arabinose catabolic process(GO:0019568)
0.2 0.6 GO:0046218 tryptophan catabolic process(GO:0006569) aromatic amino acid family catabolic process(GO:0009074) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.2 0.9 GO:0044070 regulation of anion transport(GO:0044070)
0.2 0.9 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.2 1.4 GO:0006099 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.2 1.3 GO:0015891 siderophore transport(GO:0015891)
0.2 0.8 GO:0006083 acetate metabolic process(GO:0006083)
0.2 1.1 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 0.6 GO:0046503 glycerolipid catabolic process(GO:0046503)
0.2 1.2 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.2 0.3 GO:0019388 galactose catabolic process(GO:0019388)
0.1 0.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.6 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 0.3 GO:0071456 cellular response to hypoxia(GO:0071456)
0.1 0.7 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 0.4 GO:0010039 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.1 1.9 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 1.1 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.4 GO:0071168 protein localization to chromatin(GO:0071168)
0.1 1.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.1 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.1 0.5 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.1 1.6 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.1 0.5 GO:0015847 putrescine transport(GO:0015847)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 1.0 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.1 GO:0018209 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.1 0.3 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.1 0.3 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.1 1.0 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.3 GO:0035494 SNARE complex disassembly(GO:0035494)
0.1 0.4 GO:0043937 regulation of sporulation(GO:0043937)
0.1 0.5 GO:0015793 glycerol transport(GO:0015793)
0.1 3.4 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.2 GO:0043335 protein unfolding(GO:0043335)
0.1 0.1 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 0.5 GO:0006167 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.1 0.9 GO:0006826 iron ion transport(GO:0006826)
0.1 0.8 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 1.3 GO:0042168 porphyrin-containing compound metabolic process(GO:0006778) tetrapyrrole metabolic process(GO:0033013) heme metabolic process(GO:0042168)
0.1 0.4 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.1 0.4 GO:0032370 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.1 0.4 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 1.4 GO:0015918 sterol transport(GO:0015918)
0.1 0.3 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322)
0.1 1.0 GO:0032258 CVT pathway(GO:0032258)
0.1 0.7 GO:0045912 negative regulation of cellular carbohydrate metabolic process(GO:0010677) negative regulation of carbohydrate metabolic process(GO:0045912)
0.1 0.1 GO:0001666 response to hypoxia(GO:0001666)
0.1 1.6 GO:0022900 electron transport chain(GO:0022900)
0.1 0.2 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 1.4 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.2 GO:0042743 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.1 0.5 GO:0022610 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.1 0.5 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.4 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 0.1 GO:0042148 strand invasion(GO:0042148)
0.1 0.2 GO:0032874 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.1 0.2 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.1 0.7 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.1 0.8 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.1 0.2 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.4 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.1 0.1 GO:0009743 response to carbohydrate(GO:0009743)
0.1 0.4 GO:0031134 sister chromatid biorientation(GO:0031134)
0.1 0.3 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 0.3 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 1.4 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.2 GO:0019933 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.1 0.1 GO:0031555 transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.1 0.4 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.9 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 0.1 GO:0009187 cyclic nucleotide metabolic process(GO:0009187)
0.1 0.6 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.2 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.4 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 1.1 GO:0008361 regulation of cell size(GO:0008361)
0.0 0.3 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.0 0.1 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.6 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.0 0.6 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 0.2 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.2 GO:0032973 amino acid export(GO:0032973) amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.2 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.5 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.1 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.0 0.2 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.0 0.4 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.1 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.2 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.0 0.2 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.0 0.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.1 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.2 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.1 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.0 0.2 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.0 0.2 GO:0051598 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.0 0.2 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.2 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.0 0.1 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.0 0.0 GO:0019627 urea metabolic process(GO:0019627)
0.0 0.3 GO:0010038 response to metal ion(GO:0010038)
0.0 0.2 GO:0007129 synapsis(GO:0007129)
0.0 0.7 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.0 GO:0051098 regulation of binding(GO:0051098)
0.0 0.1 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.0 GO:0045117 azole transport(GO:0045117)
0.0 0.1 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.4 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.1 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.0 0.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.4 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.4 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0019932 second-messenger-mediated signaling(GO:0019932)
0.0 0.2 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.0 0.4 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.0 GO:0043096 purine nucleobase salvage(GO:0043096)
0.0 0.5 GO:0070726 cell wall assembly(GO:0070726)
0.0 0.0 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.0 0.0 GO:0060988 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.0 0.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.1 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.1 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.0 GO:0015809 arginine transport(GO:0015809)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
1.1 3.3 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
1.0 8.7 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.9 3.5 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.7 2.7 GO:0000817 COMA complex(GO:0000817)
0.6 2.4 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.5 2.7 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.4 1.3 GO:0046930 pore complex(GO:0046930)
0.4 1.3 GO:0032177 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.4 2.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.4 0.7 GO:0030061 mitochondrial crista(GO:0030061)
0.3 2.0 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.3 1.0 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.3 1.4 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.3 3.5 GO:0070469 respiratory chain(GO:0070469)
0.3 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 1.0 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 1.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 0.7 GO:0035649 Nrd1 complex(GO:0035649)
0.2 0.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 9.9 GO:0031225 anchored component of membrane(GO:0031225)
0.2 0.8 GO:0033309 SBF transcription complex(GO:0033309)
0.2 0.8 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 0.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 1.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 3.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.4 GO:0001400 mating projection base(GO:0001400)
0.1 6.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.7 GO:0034657 GID complex(GO:0034657)
0.1 2.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.3 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.1 1.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 12.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.2 GO:0005784 Sec61 translocon complex(GO:0005784)
0.1 2.0 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.4 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 0.4 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.5 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.5 GO:0005619 ascospore wall(GO:0005619) spore wall(GO:0031160)
0.1 0.6 GO:0000942 condensed chromosome outer kinetochore(GO:0000940) condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.1 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.3 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.2 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.2 GO:0034967 Set3 complex(GO:0034967)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 1.2 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 0.4 GO:0033698 Rpd3L complex(GO:0033698)
0.0 0.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.0 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.1 GO:0032806 carboxy-terminal domain protein kinase complex(GO:0032806)
0.0 0.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.4 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.1 GO:0033101 cellular bud membrane(GO:0033101)
0.0 0.1 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.6 4.9 GO:0016208 AMP binding(GO:0016208)
1.5 6.0 GO:0004396 hexokinase activity(GO:0004396)
1.5 7.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
1.3 4.0 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.0 4.2 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
1.0 2.0 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
1.0 3.9 GO:0005537 mannose binding(GO:0005537)
0.9 7.1 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.8 2.5 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.8 2.4 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.7 2.0 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.6 7.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6 3.0 GO:0015295 solute:proton symporter activity(GO:0015295)
0.6 2.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.6 3.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.5 1.6 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.5 1.5 GO:0004629 phospholipase C activity(GO:0004629)
0.5 2.3 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.5 1.4 GO:0016289 CoA hydrolase activity(GO:0016289)
0.4 1.3 GO:0008308 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.4 4.4 GO:0015293 symporter activity(GO:0015293)
0.4 1.5 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.4 1.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.4 2.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 2.9 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.4 1.4 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3 1.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.3 0.8 GO:0048038 quinone binding(GO:0048038)
0.3 1.1 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.3 1.4 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.3 2.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 0.8 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.2 0.7 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.2 1.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.2 3.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 0.9 GO:0008169 C-methyltransferase activity(GO:0008169)
0.2 1.1 GO:0008198 ferrous iron binding(GO:0008198)
0.2 0.8 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.2 2.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.8 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.2 0.8 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.2 0.8 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.2 1.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.2 1.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 0.9 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.2 0.2 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.2 1.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 0.5 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.2 1.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379) peroxiredoxin activity(GO:0051920)
0.2 0.8 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.2 0.6 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.2 4.3 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.2 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 2.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.5 GO:0016209 antioxidant activity(GO:0016209)
0.1 0.6 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 0.4 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 0.5 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.1 0.4 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.1 0.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.9 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 0.3 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.4 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.1 0.7 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 1.0 GO:0099600 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.1 1.1 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.8 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 1.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.5 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.6 GO:0034979 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.1 0.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.7 GO:0031386 protein tag(GO:0031386)
0.1 0.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 1.3 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 0.4 GO:0001004 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.1 1.0 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.2 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.3 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.6 GO:0005507 copper ion binding(GO:0005507)
0.0 0.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 1.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.3 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.2 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.5 GO:0051015 actin filament binding(GO:0051015)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.2 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 1.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.2 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.0 0.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0015658 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.0 0.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.4 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.6 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.1 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.0 0.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.0 GO:0001026 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.0 0.1 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.2 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.3 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.5 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.1 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.0 0.1 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.9 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.0 GO:0016972 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) thiol oxidase activity(GO:0016972)
0.0 0.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 0.0 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.0 0.0 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.0 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.0 GO:0045118 azole transporter activity(GO:0045118)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.4 3.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.3 0.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 0.7 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 0.5 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 28.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.3 0.8 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.2 1.9 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 2.2 REACTOME DNA REPAIR Genes involved in DNA Repair
0.2 0.3 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 0.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.1 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 27.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.1 REACTOME MEMBRANE TRAFFICKING Genes involved in Membrane Trafficking
0.0 0.0 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.0 0.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein