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Results for SFP1

Z-value: 6.73

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Transcription factors associated with SFP1

Gene Symbol Gene ID Gene Info
SFP1
S000004395 Regulates transcription of ribosomal protein and biogenesis genes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SFP1YLR403W-0.815.3e-07Click!

Activity profile of SFP1 motif

Sorted Z-values of SFP1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YHR094C 86.95
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YFR055W 62.25
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YJL148W 55.39
RPA34
RNA polymerase I subunit A34.5
YFR056C 54.46 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YDR345C 48.39
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YOR047C 43.10
STD1
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YLR372W 37.44
SUR4
Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YAL038W 36.13
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YPL037C 34.33
EGD1
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YJR070C 33.63
LIA1
Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YEL040W 33.06
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YJR071W 32.12 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL014W 31.98
NOP1
Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YOR340C 31.02
RPA43
RNA polymerase I subunit A43
YGR108W 30.77
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YLR150W 29.36
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YNR001W-A 29.31 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YLR175W 28.88
CBF5
Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2
YMR083W 28.40
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YDR033W 27.76
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YGR264C 27.34
MES1
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YER070W 27.32
RNR1
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YER131W 26.76
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YLR197W 26.66
SIK1
Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YGR265W 26.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YGR195W 26.41
SKI6
3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YOR342C 25.79 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YKL081W 25.30
TEF4
Translation elongation factor EF-1 gamma
YMR011W 25.10
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YGR155W 24.77
CYS4
Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YOR309C 24.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
YDR344C 24.38 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNR053C 24.18
NOG2
Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YMR116C 23.92
ASC1
G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
YGL209W 23.88
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YOR167C 23.79
RPS28A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein
YPR014C 23.70 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YOR212W 22.55
STE4
G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
YDR044W 22.45
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YBL003C 22.32
HTA2
One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YLR029C 22.32
RPL15A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YOL086C 22.09
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YBL039C 22.03
URA7
Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YGL008C 21.56
PMA1
Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases
YKL218C 21.55
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YOR272W 21.45
YTM1
Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YEL026W 21.44
SNU13
RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
YJL011C 21.42
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YJL200C 21.29
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YGR103W 21.20
NOP7
Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles; required for exit from G0 and the initiation of cell proliferation
YNL112W 20.78
DBP2
Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing
YBR121C 20.38
GRS1
Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
YDL037C 20.29
BSC1
Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YFL022C 20.22
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YAL003W 19.96
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YGL157W 19.95 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YLR110C 19.82
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YNL111C 19.78
CYB5
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YGR123C 19.67
PPT1
Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YOR293W 19.67
RPS10A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
YHR196W 19.62
UTP9
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YOL097C 19.58
WRS1
Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
YGR280C 19.50
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YLR022C 19.33
SDO1
Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes
YBL085W 19.30
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YBR154C 19.17
RPB5
RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
YDL211C 19.00 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YBR143C 18.98
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YBR238C 18.78 Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
YMR290C 18.72
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YGL078C 18.51
DBP3
Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YNL182C 18.47
IPI3
Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YBR158W 18.43
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YMR290W-A 18.43 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YPR044C 18.30
OPI11
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO
YBL002W 18.01
HTB2
One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YKL110C 17.92
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YLR367W 17.90
RPS22B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YDR023W 17.83
SES1
Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YLR449W 17.76
FPR4
Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YPL075W 17.66
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YOR315W 17.65
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YML106W 17.31
URA5
Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; minor OPRTase encoded by URA10
YLR432W 17.28
IMD3
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YOR271C 17.19
FSF1
Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YGR185C 17.13
TYS1
Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr
YDL055C 17.13
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YBL092W 17.13
RPL32
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YHR193C 17.08
EGD2
Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
YPR069C 17.03
SPE3
Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
YGR124W 16.97
ASN2
Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YDR101C 16.90
ARX1
Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YDL229W 16.88
SSB1
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p
YOR234C 16.76
RPL33B
Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YIL074C 16.57
SER33
3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p
YOR222W 16.28
ODC2
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YHR089C 16.24
GAR1
Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YPL245W 16.22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YJL198W 15.85
PHO90
Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YIL169C 15.85 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YBR249C 15.82
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YKL120W 15.80
OAC1
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YOR376W-A 15.79 Putative protein of unknown function; identified by fungal homology and RT-PCR
YKR094C 15.78
RPL40B
Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YLR409C 15.74
UTP21
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YOR168W 15.69
GLN4
Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions
YMR082C 15.67 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL059C 15.61
KRR1
Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
YNL289W 15.51
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YOR369C 15.36
RPS12
Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YOR096W 15.31
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YNL175C 15.27
NOP13
Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA
YPR110C 15.18
RPC40
RNA polymerase subunit, common to RNA polymerase I and III
YBL027W 15.17
RPL19B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YJR016C 15.12
ILV3
Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
YPR010C 15.08
RPA135
RNA polymerase I subunit A135
YLR249W 15.05
YEF3
Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YFR054C 15.03 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR095C 15.01 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR216W 14.85
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YDR094W 14.81 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YKL216W 14.79
URA1
Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YLR435W 14.79
TSR2
Protein with a potential role in pre-rRNA processing
YDR417C 14.66 Hypothetical protein
YER043C 14.59
SAH1
S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YOR072W-B 14.46 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YNL113W 14.29
RPC19
RNA polymerase subunit, common to RNA polymerases I and III
YPL093W 14.23
NOG1
Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
YBL028C 14.12 Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YOR310C 14.12
NOP58
Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YNL132W 14.04
KRE33
Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
YER011W 13.99
TIR1
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YGR266W 13.99 Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
YOR063W 13.96
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YHL034C 13.87
SBP1
Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
YAL059W 13.68
ECM1
Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export
YDR341C 13.59 Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR088C 13.40
SLU7
RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YHR197W 13.34
RIX1
Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YOL130W 13.32
ALR1
Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YBR032W 13.32 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YJL080C 13.30
SCP160
Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
YOR004W 13.21
UTP23
Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function
YIL158W 13.19
AIM20
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YDR385W 13.17
EFT2
Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YLR009W 13.15
RLP24
Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis
YIL069C 13.04
RPS24B
Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YOR375C 12.92
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YBR087W 12.91
RFC5
Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YGL105W 12.86
ARC1
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
YLR061W 12.85
RPL22A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein
YOR341W 12.79
RPA190
RNA polymerase I subunit; largest subunit of RNA polymerase I
YBL024W 12.79
NCL1
S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120
YMR217W 12.77
GUA1
GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YOR312C 12.76
RPL20B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
YLR060W 12.72
FRS1
Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; sequence is evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase (Msf1p), but substrate binding is similar
YHR052W 12.69
CIC1
Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
YLR075W 12.65
RPL10
Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YEL053W-A 12.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YDL208W 12.59
NHP2
Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
YOR133W 12.58
EFT1
Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YBR084C-A 12.41
RPL19A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YKL009W 12.34
MRT4
Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YDR365C 12.29
ESF1
Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
YML074C 12.28
FPR3
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YPR132W 12.23
RPS23B
Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YPL178W 12.16
CBC2
Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YGR138C 12.13
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YER126C 12.07
NSA2
Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
YJR123W 12.03
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YLR048W 11.87
RPS0B
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YOR029W 11.66 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGR085C 11.65
RPL11B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YOL049W 11.64
GSH2
Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
YER156C 11.62 Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YAL033W 11.53
POP5
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YLR355C 11.53
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YPR148C 11.52 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YPL142C 11.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
YGL120C 11.47
PRP43
RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YAL012W 11.44
CYS3
Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine
YGL070C 11.43
RPB9
RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance
YOL121C 11.42
RPS19A
Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp
YAL007C 11.41
ERP2
Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YMR106C 11.37
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YMR009W 11.36
ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YOR254C 11.33
SEC63
Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YDR037W 11.32
KRS1
Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YMR296C 11.31
LCB1
Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YAL025C 11.24
MAK16
Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YMR146C 11.22
TIF34
Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation
YPR163C 11.19
TIF3
Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YER009W 11.10
NTF2
Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
YLR196W 11.09
PWP1
Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YER134C 10.98 Putative protein of unknown function; non-essential gene
YGL039W 10.98 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YGR036C 10.98
CAX4
Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YJR047C 10.96
ANB1
Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions
YJL109C 10.95
UTP10
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YNL114C 10.94 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of SFP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
20.8 62.4 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
14.9 74.3 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
14.4 43.1 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
14.2 56.9 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
13.2 13.2 GO:0045901 positive regulation of translational elongation(GO:0045901)
11.1 44.6 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
11.1 55.6 GO:0006177 GMP biosynthetic process(GO:0006177)
11.0 32.9 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
10.7 42.9 GO:0030497 fatty acid elongation(GO:0030497)
9.9 39.6 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
9.8 29.4 GO:0043066 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
9.1 36.2 GO:0019346 transsulfuration(GO:0019346)
8.4 8.4 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
8.2 32.9 GO:0042256 mature ribosome assembly(GO:0042256)
7.8 23.5 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
7.8 15.7 GO:0008216 spermidine metabolic process(GO:0008216)
7.7 138.0 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
7.6 22.7 GO:0002188 translation reinitiation(GO:0002188)
7.5 134.7 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
6.9 20.7 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
6.8 121.8 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
6.7 26.8 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
6.6 73.0 GO:0034963 box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963)
6.3 195.9 GO:0034471 rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
6.3 50.2 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
6.2 43.4 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
6.0 18.1 GO:0006529 asparagine biosynthetic process(GO:0006529)
5.9 29.7 GO:0007535 donor selection(GO:0007535)
5.7 17.1 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
5.7 186.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
5.6 22.3 GO:0098610 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
5.6 172.5 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
5.6 16.7 GO:0072363 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
5.6 16.7 GO:0015740 C4-dicarboxylate transport(GO:0015740)
5.5 60.6 GO:0015758 glucose transport(GO:0015758)
5.5 247.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
5.4 16.3 GO:0043096 purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083)
5.3 16.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
5.3 21.0 GO:0000296 spermine transport(GO:0000296)
4.9 14.8 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
4.7 23.5 GO:0042593 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
4.5 241.0 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
4.5 26.7 GO:0009099 valine biosynthetic process(GO:0009099)
4.3 47.6 GO:0006415 translational termination(GO:0006415)
4.3 12.9 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
4.2 21.1 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
4.1 16.5 GO:0031057 negative regulation of histone modification(GO:0031057)
4.1 111.0 GO:0033750 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
4.1 16.4 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
4.0 28.3 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
4.0 48.1 GO:0071047 nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
4.0 15.8 GO:0009423 chorismate biosynthetic process(GO:0009423)
3.9 397.4 GO:0002181 cytoplasmic translation(GO:0002181)
3.8 7.7 GO:0016094 polyprenol metabolic process(GO:0016093) polyprenol biosynthetic process(GO:0016094) dolichol metabolic process(GO:0019348) dolichol biosynthetic process(GO:0019408)
3.8 3.8 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
3.7 25.6 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
3.6 17.9 GO:0006564 L-serine biosynthetic process(GO:0006564)
3.4 34.3 GO:0006116 NADH oxidation(GO:0006116)
3.4 10.2 GO:0046416 D-amino acid metabolic process(GO:0046416)
3.3 6.7 GO:0044209 AMP salvage(GO:0044209)
3.3 13.3 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
3.2 3.2 GO:0042255 ribosome assembly(GO:0042255)
3.2 9.5 GO:0031167 rRNA methylation(GO:0031167)
3.1 15.4 GO:0046655 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
3.0 12.2 GO:0009130 UMP biosynthetic process(GO:0006222) pyrimidine nucleoside monophosphate metabolic process(GO:0009129) pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
2.9 20.4 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
2.8 11.4 GO:0071265 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
2.8 65.2 GO:0006414 translational elongation(GO:0006414)
2.8 14.1 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
2.8 11.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
2.8 30.3 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
2.7 43.7 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
2.7 46.3 GO:0030488 tRNA methylation(GO:0030488)
2.7 8.1 GO:0006571 tyrosine biosynthetic process(GO:0006571)
2.6 7.9 GO:0019413 acetate biosynthetic process(GO:0019413)
2.5 22.7 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
2.5 39.8 GO:0006037 cell wall chitin metabolic process(GO:0006037)
2.5 14.8 GO:0001522 pseudouridine synthesis(GO:0001522)
2.5 7.4 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
2.5 12.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
2.4 26.5 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
2.4 19.2 GO:0006814 sodium ion transport(GO:0006814)
2.4 4.8 GO:0034284 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
2.4 14.2 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
2.3 9.0 GO:0015909 long-chain fatty acid transport(GO:0015909)
2.2 104.2 GO:0006364 rRNA processing(GO:0006364)
2.2 8.8 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
2.2 4.4 GO:0006549 isoleucine metabolic process(GO:0006549)
2.2 6.6 GO:0015693 magnesium ion transport(GO:0015693)
2.2 22.0 GO:0006272 leading strand elongation(GO:0006272)
2.2 8.6 GO:0060188 regulation of protein desumoylation(GO:0060188)
2.1 18.8 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
2.0 11.8 GO:0009088 threonine biosynthetic process(GO:0009088)
1.9 17.5 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
1.9 5.8 GO:0042780 tRNA 3'-end processing(GO:0042780)
1.9 7.6 GO:0015780 nucleotide-sugar transport(GO:0015780)
1.9 7.6 GO:0019358 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
1.8 1.8 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
1.8 7.4 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
1.7 1.7 GO:0009090 homoserine biosynthetic process(GO:0009090)
1.7 10.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
1.7 23.9 GO:0030473 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
1.7 3.4 GO:0007188 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187) adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
1.7 6.7 GO:0048313 Golgi inheritance(GO:0048313)
1.6 42.8 GO:0046031 purine nucleoside diphosphate metabolic process(GO:0009135) purine ribonucleoside diphosphate metabolic process(GO:0009179) ribonucleoside diphosphate metabolic process(GO:0009185) ADP metabolic process(GO:0046031)
1.6 8.2 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
1.6 9.8 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
1.6 8.0 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
1.6 30.4 GO:0006334 nucleosome assembly(GO:0006334)
1.6 3.2 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
1.6 14.2 GO:0000022 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
1.6 9.4 GO:0045014 negative regulation of transcription from RNA polymerase II promoter by glucose(GO:0000433) negative regulation of transcription by glucose(GO:0045014)
1.6 9.4 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
1.6 3.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
1.5 9.2 GO:0042538 hyperosmotic salinity response(GO:0042538)
1.5 21.2 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
1.5 4.5 GO:0043171 peptide catabolic process(GO:0043171)
1.5 21.1 GO:0006446 regulation of translational initiation(GO:0006446)
1.5 6.0 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
1.5 3.0 GO:0006596 polyamine biosynthetic process(GO:0006596)
1.5 2.9 GO:0007030 Golgi organization(GO:0007030)
1.5 1.5 GO:0070189 kynurenine metabolic process(GO:0070189)
1.5 2.9 GO:0070827 chromatin maintenance(GO:0070827)
1.4 5.8 GO:0043094 cellular metabolic compound salvage(GO:0043094)
1.4 14.5 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
1.4 1.4 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898) response to ketone(GO:1901654)
1.4 4.2 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
1.4 5.5 GO:0015886 heme transport(GO:0015886)
1.4 1.4 GO:0006531 aspartate metabolic process(GO:0006531)
1.3 49.5 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
1.3 2.6 GO:0048194 Golgi vesicle budding(GO:0048194)
1.3 4.0 GO:0006517 protein deglycosylation(GO:0006517)
1.3 15.7 GO:0090002 protein localization to plasma membrane(GO:0072659) establishment of protein localization to plasma membrane(GO:0090002) protein localization to cell periphery(GO:1990778)
1.3 32.6 GO:0006413 translational initiation(GO:0006413)
1.3 1.3 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015)
1.3 46.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
1.3 1.3 GO:0071039 CUT catabolic process(GO:0071034) nuclear polyadenylation-dependent CUT catabolic process(GO:0071039) CUT metabolic process(GO:0071043)
1.3 2.5 GO:0010793 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
1.2 1.2 GO:0070868 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
1.2 6.2 GO:0010455 positive regulation of cell fate commitment(GO:0010455) positive regulation of mating type switching(GO:0031496) positive regulation of cell differentiation(GO:0045597) positive regulation of developmental process(GO:0051094)
1.2 2.4 GO:0000092 mitotic anaphase B(GO:0000092)
1.2 16.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
1.2 14.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
1.2 5.9 GO:0043555 regulation of translation in response to stress(GO:0043555)
1.2 9.3 GO:0051598 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
1.2 4.6 GO:0019184 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
1.1 4.6 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
1.1 4.5 GO:0032988 ribonucleoprotein complex disassembly(GO:0032988)
1.1 1.1 GO:0046037 GMP metabolic process(GO:0046037)
1.1 2.2 GO:0035953 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
1.1 7.7 GO:0032447 protein urmylation(GO:0032447)
1.1 5.5 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
1.1 4.3 GO:0009113 purine nucleobase biosynthetic process(GO:0009113) nucleobase biosynthetic process(GO:0046112)
1.1 13.0 GO:0007120 axial cellular bud site selection(GO:0007120)
1.1 5.3 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole biosynthetic process(GO:0033014)
1.0 1.0 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
1.0 7.1 GO:0007323 peptide pheromone maturation(GO:0007323)
1.0 3.0 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
1.0 14.9 GO:0006555 methionine metabolic process(GO:0006555)
1.0 43.8 GO:0008033 tRNA processing(GO:0008033)
1.0 8.8 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
1.0 10.5 GO:0006999 nuclear pore organization(GO:0006999)
0.9 1.9 GO:0010695 regulation of spindle pole body separation(GO:0010695)
0.9 4.7 GO:0006551 leucine metabolic process(GO:0006551) leucine biosynthetic process(GO:0009098)
0.9 7.3 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.9 6.2 GO:0030031 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
0.9 8.9 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.8 3.4 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.8 7.6 GO:0032508 DNA duplex unwinding(GO:0032508)
0.8 0.8 GO:0071482 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.8 2.4 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.8 3.1 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.7 3.0 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.7 5.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.7 2.2 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.7 2.1 GO:0001174 DNA-templated transcriptional start site selection(GO:0001173) transcriptional start site selection at RNA polymerase II promoter(GO:0001174)
0.7 2.0 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.7 7.5 GO:0016125 steroid metabolic process(GO:0008202) sterol metabolic process(GO:0016125)
0.7 16.8 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.7 4.0 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.6 3.2 GO:0006972 hyperosmotic response(GO:0006972)
0.6 2.5 GO:0018344 protein geranylgeranylation(GO:0018344)
0.6 1.9 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.6 0.6 GO:0051664 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.6 5.4 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.6 1.7 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.6 2.9 GO:0006613 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.6 6.2 GO:0009636 response to toxic substance(GO:0009636)
0.6 2.8 GO:0006885 regulation of pH(GO:0006885)
0.6 11.6 GO:0051445 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.5 2.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.5 0.5 GO:0009094 L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.5 3.2 GO:0006998 nuclear envelope organization(GO:0006998)
0.5 3.8 GO:0006284 base-excision repair(GO:0006284)
0.5 9.6 GO:0006915 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.5 5.9 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.5 1.6 GO:0008299 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.5 3.2 GO:0009306 protein secretion(GO:0009306)
0.5 4.7 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.5 5.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.5 2.0 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.5 1.0 GO:0015867 ATP transport(GO:0015867)
0.5 0.5 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.5 2.0 GO:0009452 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260)
0.5 1.5 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.5 3.8 GO:0000321 re-entry into mitotic cell cycle(GO:0000320) re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.5 3.8 GO:0009303 rRNA transcription(GO:0009303)
0.5 1.4 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.5 2.7 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.5 0.9 GO:0045842 positive regulation of mitotic nuclear division(GO:0045840) positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101) positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.5 1.4 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.4 7.3 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.4 1.3 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.4 2.1 GO:0051325 interphase(GO:0051325) mitotic interphase(GO:0051329)
0.4 0.8 GO:0030046 parallel actin filament bundle assembly(GO:0030046) formin-nucleated actin cable assembly(GO:0070649)
0.4 3.3 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.4 3.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.4 9.9 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.4 25.9 GO:0006839 mitochondrial transport(GO:0006839)
0.4 2.9 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.4 1.9 GO:0009073 aromatic amino acid family biosynthetic process(GO:0009073)
0.4 3.4 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.4 2.6 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.4 1.5 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.4 1.8 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.4 1.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.3 0.7 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.3 2.4 GO:0042991 transcription factor import into nucleus(GO:0042991)
0.3 2.6 GO:2001252 positive regulation of chromosome organization(GO:2001252)
0.3 2.9 GO:0006862 nucleotide transport(GO:0006862)
0.3 2.2 GO:0042726 flavin-containing compound metabolic process(GO:0042726) flavin-containing compound biosynthetic process(GO:0042727)
0.3 4.0 GO:0045727 positive regulation of translation(GO:0045727)
0.3 4.9 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.3 0.6 GO:0036213 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.3 1.5 GO:0070941 eisosome assembly(GO:0070941)
0.3 0.3 GO:0009411 response to UV(GO:0009411)
0.3 1.4 GO:0046351 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.3 13.7 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.3 0.5 GO:0031494 regulation of cell fate commitment(GO:0010453) regulation of mating type switching(GO:0031494)
0.3 2.3 GO:0015833 peptide transport(GO:0015833)
0.2 0.7 GO:0009607 response to biotic stimulus(GO:0009607)
0.2 3.5 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.2 3.2 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.2 2.5 GO:0030474 spindle pole body duplication(GO:0030474)
0.2 1.6 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.2 2.1 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 1.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 2.8 GO:0006606 protein import into nucleus(GO:0006606) nuclear import(GO:0051170) single-organism nuclear import(GO:1902593)
0.2 1.6 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.2 0.8 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.2 0.6 GO:0000032 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.2 0.7 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.2 2.5 GO:0072503 cellular divalent inorganic cation homeostasis(GO:0072503) divalent inorganic cation homeostasis(GO:0072507)
0.2 0.7 GO:0006465 signal peptide processing(GO:0006465)
0.2 2.4 GO:0030242 pexophagy(GO:0030242)
0.2 3.5 GO:0043248 proteasome assembly(GO:0043248)
0.2 0.7 GO:2000242 negative regulation of reproductive process(GO:2000242)
0.2 0.7 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.2 0.8 GO:0006816 calcium ion transport(GO:0006816)
0.2 0.5 GO:0045833 negative regulation of lipid metabolic process(GO:0045833)
0.2 0.6 GO:0036010 protein localization to endosome(GO:0036010)
0.2 0.3 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 0.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 1.2 GO:0006997 nucleus organization(GO:0006997)
0.1 7.6 GO:0006457 protein folding(GO:0006457)
0.1 2.3 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.1 0.4 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.3 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.1 0.4 GO:0030308 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.1 0.8 GO:0015791 polyol transport(GO:0015791)
0.1 6.9 GO:0000398 mRNA splicing, via spliceosome(GO:0000398)
0.1 0.2 GO:0070828 heterochromatin organization(GO:0070828)
0.1 0.7 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.3 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 0.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.1 GO:0006399 tRNA metabolic process(GO:0006399)
0.1 0.2 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.1 0.3 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.1 0.3 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.3 GO:0006083 acetate metabolic process(GO:0006083)
0.1 1.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.3 GO:0006273 lagging strand elongation(GO:0006273)
0.1 0.1 GO:0042148 strand invasion(GO:0042148)
0.1 0.4 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.3 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.0 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.3 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.1 GO:0051294 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.0 0.1 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 0.7 GO:0016311 dephosphorylation(GO:0016311)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
17.1 51.4 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
16.9 50.7 GO:0070545 PeBoW complex(GO:0070545)
16.9 67.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
15.8 63.4 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
14.4 43.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
14.1 197.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
12.1 36.4 GO:0097344 Rix1 complex(GO:0097344)
10.5 52.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
9.1 63.7 GO:0034455 t-UTP complex(GO:0034455)
8.5 50.7 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
8.2 32.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
6.8 20.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
6.6 13.3 GO:0030689 Noc complex(GO:0030689)
6.5 19.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
6.3 295.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
6.1 6.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
5.9 23.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
5.8 29.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
5.6 28.1 GO:0043614 multi-eIF complex(GO:0043614)
5.5 55.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
5.2 134.8 GO:0032040 small-subunit processome(GO:0032040)
5.1 260.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
4.8 149.4 GO:0030684 preribosome(GO:0030684)
4.8 456.3 GO:0022626 cytosolic ribosome(GO:0022626)
4.3 17.4 GO:0042788 polysomal ribosome(GO:0042788)
4.3 59.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
4.2 25.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
3.9 15.6 GO:0044611 nuclear pore inner ring(GO:0044611)
3.9 15.4 GO:0031207 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
3.7 18.6 GO:0031391 Elg1 RFC-like complex(GO:0031391)
3.7 33.0 GO:0000144 cellular bud neck septin ring(GO:0000144)
3.6 14.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
3.6 10.9 GO:0000814 ESCRT II complex(GO:0000814)
3.1 9.2 GO:0030428 cell septum(GO:0030428)
3.0 17.8 GO:0042555 MCM complex(GO:0042555)
2.9 20.4 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
2.9 8.7 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
2.8 16.6 GO:0043527 tRNA methyltransferase complex(GO:0043527)
2.7 32.5 GO:0000788 nuclear nucleosome(GO:0000788)
2.7 45.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
2.6 307.1 GO:0005730 nucleolus(GO:0005730)
2.5 54.6 GO:0005844 polysome(GO:0005844)
2.5 9.9 GO:0031518 CBF3 complex(GO:0031518)
2.5 7.4 GO:0033186 CAF-1 complex(GO:0033186)
2.4 12.2 GO:0034518 RNA cap binding complex(GO:0034518)
2.4 9.6 GO:0033176 vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176)
2.3 6.8 GO:0070209 ASTRA complex(GO:0070209) R2TP complex(GO:0097255)
2.2 19.9 GO:0005832 chaperonin-containing T-complex(GO:0005832)
2.0 12.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
1.8 10.6 GO:0031933 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
1.7 3.4 GO:0000792 heterochromatin(GO:0000792)
1.6 9.7 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
1.6 11.0 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
1.5 9.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
1.5 6.2 GO:0017053 transcriptional repressor complex(GO:0017053)
1.5 6.0 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
1.5 8.9 GO:0005871 kinesin complex(GO:0005871)
1.4 11.3 GO:0030126 COPI vesicle coat(GO:0030126)
1.4 1.4 GO:0005880 nuclear microtubule(GO:0005880)
1.4 9.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
1.3 4.0 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
1.3 3.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
1.3 3.8 GO:0070985 TFIIK complex(GO:0070985)
1.2 7.3 GO:0000136 alpha-1,6-mannosyltransferase complex(GO:0000136)
1.2 6.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
1.2 4.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.2 4.8 GO:0030906 retromer, cargo-selective complex(GO:0030906)
1.2 5.8 GO:0005641 nuclear envelope lumen(GO:0005641)
1.1 3.3 GO:0005796 Golgi lumen(GO:0005796)
1.0 5.2 GO:0016272 prefoldin complex(GO:0016272)
1.0 17.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
1.0 9.1 GO:0000243 commitment complex(GO:0000243)
1.0 8.7 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.9 0.9 GO:0005688 U6 snRNP(GO:0005688)
0.9 10.1 GO:0034399 nuclear periphery(GO:0034399)
0.9 3.7 GO:0005797 Golgi medial cisterna(GO:0005797)
0.9 29.9 GO:0044445 cytosolic part(GO:0044445)
0.9 4.5 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.9 2.6 GO:0044697 HICS complex(GO:0044697)
0.8 13.6 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.8 5.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.8 2.5 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.8 5.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.8 28.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.8 5.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.8 5.4 GO:0016459 myosin complex(GO:0016459)
0.8 8.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.7 1.5 GO:0008278 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.7 2.2 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.7 2.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.7 4.2 GO:0030125 clathrin vesicle coat(GO:0030125)
0.7 4.9 GO:0005791 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.7 26.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.7 2.6 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.6 5.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.6 4.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.6 11.7 GO:0030133 transport vesicle(GO:0030133)
0.6 14.4 GO:0005802 trans-Golgi network(GO:0005802)
0.6 1.7 GO:0070823 HDA1 complex(GO:0070823)
0.6 3.5 GO:0000133 polarisome(GO:0000133)
0.5 6.0 GO:0005685 U1 snRNP(GO:0005685)
0.5 1.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.5 4.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.5 0.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.5 2.8 GO:0005940 septin ring(GO:0005940)
0.4 1.8 GO:0000811 GINS complex(GO:0000811)
0.4 0.4 GO:0030286 dynein complex(GO:0030286)
0.4 2.0 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.4 1.2 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.4 0.8 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.4 55.2 GO:0005933 cellular bud(GO:0005933)
0.4 1.5 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.4 1.4 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.3 12.1 GO:0005811 lipid particle(GO:0005811)
0.3 2.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.3 4.7 GO:0030659 vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659)
0.3 3.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 1.2 GO:0000817 COMA complex(GO:0000817)
0.3 4.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.3 0.9 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.3 0.9 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.3 2.1 GO:0042597 periplasmic space(GO:0042597)
0.3 45.6 GO:0005829 cytosol(GO:0005829)
0.3 1.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.3 20.7 GO:0005635 nuclear envelope(GO:0005635)
0.3 1.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.3 1.6 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 2.3 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.2 1.0 GO:0000938 GARP complex(GO:0000938)
0.2 0.7 GO:0005787 signal peptidase complex(GO:0005787)
0.2 1.6 GO:0000346 transcription export complex(GO:0000346)
0.2 2.5 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.2 2.9 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 2.2 GO:0032300 mismatch repair complex(GO:0032300)
0.2 4.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 17.0 GO:0005840 ribosome(GO:0005840)
0.2 0.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.1 0.9 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 0.6 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 0.5 GO:0055087 Ski complex(GO:0055087)
0.1 0.3 GO:0097196 Shu complex(GO:0097196)
0.1 0.5 GO:0034967 Set3 complex(GO:0034967)
0.1 6.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 0.3 GO:0030135 coated vesicle(GO:0030135)
0.1 0.3 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 0.1 GO:0030897 HOPS complex(GO:0030897)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
14.7 58.8 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
14.3 42.9 GO:0009922 fatty acid elongase activity(GO:0009922)
14.1 197.5 GO:0001054 RNA polymerase I activity(GO:0001054)
11.0 32.9 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
10.7 32.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
9.0 45.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
8.9 35.6 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
8.2 32.8 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
8.0 47.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
7.9 31.8 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
7.3 146.7 GO:0030515 snoRNA binding(GO:0030515)
6.7 26.7 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
6.6 98.6 GO:0003746 translation elongation factor activity(GO:0003746)
6.5 25.8 GO:0016841 ammonia-lyase activity(GO:0016841)
6.4 19.3 GO:0070568 guanylyltransferase activity(GO:0070568)
5.8 57.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
5.5 55.4 GO:0001056 RNA polymerase III activity(GO:0001056)
5.5 16.5 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
5.5 22.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
5.5 27.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
5.4 16.3 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
5.3 16.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
5.3 21.0 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
5.3 31.5 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
5.1 159.6 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
5.1 15.4 GO:0051010 microtubule plus-end binding(GO:0051010)
5.0 15.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
5.0 39.8 GO:0019843 rRNA binding(GO:0019843)
4.9 14.8 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
4.9 14.6 GO:0097617 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
4.8 47.8 GO:0004497 monooxygenase activity(GO:0004497)
4.7 14.0 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
4.5 49.2 GO:0030295 protein kinase activator activity(GO:0030295)
4.3 126.0 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
4.2 21.2 GO:0008186 RNA-dependent ATPase activity(GO:0008186)
4.2 25.4 GO:0016408 C-acyltransferase activity(GO:0016408)
4.2 21.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
4.1 24.4 GO:0070300 phosphatidic acid binding(GO:0070300)
4.1 12.2 GO:0000339 RNA cap binding(GO:0000339)
3.8 11.5 GO:0042134 rRNA primary transcript binding(GO:0042134)
3.7 7.3 GO:0008097 5S rRNA binding(GO:0008097)
3.6 3.6 GO:0003924 GTPase activity(GO:0003924)
3.6 54.3 GO:0000049 tRNA binding(GO:0000049)
3.5 10.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
3.4 10.1 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
3.3 23.0 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
3.2 12.7 GO:0008536 Ran GTPase binding(GO:0008536)
3.0 619.1 GO:0003735 structural constituent of ribosome(GO:0003735)
3.0 18.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
3.0 6.0 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
3.0 50.7 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
2.9 5.9 GO:0016778 diphosphotransferase activity(GO:0016778)
2.9 8.7 GO:0070336 flap-structured DNA binding(GO:0070336)
2.9 8.6 GO:0070567 cytidylyltransferase activity(GO:0070567)
2.8 8.5 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
2.7 71.9 GO:0008135 translation factor activity, RNA binding(GO:0008135)
2.6 10.6 GO:0019206 nucleoside kinase activity(GO:0019206)
2.6 10.4 GO:0009378 four-way junction helicase activity(GO:0009378)
2.6 10.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
2.5 7.6 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
2.5 12.7 GO:0019201 nucleotide kinase activity(GO:0019201)
2.5 49.2 GO:0042162 telomeric DNA binding(GO:0042162)
2.3 9.1 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
2.2 26.9 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
2.2 49.2 GO:0016836 hydro-lyase activity(GO:0016836)
2.2 6.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
2.2 53.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
2.1 6.4 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
2.1 4.3 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
2.1 10.3 GO:0004707 MAP kinase activity(GO:0004707)
2.0 6.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
2.0 19.6 GO:0005216 ion channel activity(GO:0005216)
2.0 15.7 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
1.9 9.7 GO:0008649 rRNA methyltransferase activity(GO:0008649)
1.9 5.8 GO:0019202 amino acid kinase activity(GO:0019202)
1.8 9.0 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
1.8 7.2 GO:0008143 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
1.8 7.2 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
1.8 62.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
1.8 7.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
1.8 5.3 GO:0016882 cyclo-ligase activity(GO:0016882)
1.7 5.2 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
1.7 13.9 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
1.7 5.2 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
1.6 9.9 GO:0019237 centromeric DNA binding(GO:0019237)
1.6 6.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
1.6 3.2 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467) fatty acid ligase activity(GO:0015645)
1.6 19.1 GO:0005516 calmodulin binding(GO:0005516)
1.5 6.2 GO:0004622 lysophospholipase activity(GO:0004622)
1.5 7.7 GO:0003724 RNA helicase activity(GO:0003724)
1.5 44.4 GO:0046982 protein heterodimerization activity(GO:0046982)
1.5 7.6 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
1.5 6.0 GO:0008172 S-methyltransferase activity(GO:0008172)
1.5 3.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
1.4 14.3 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
1.4 19.9 GO:0001671 ATPase activator activity(GO:0001671)
1.4 12.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
1.4 13.5 GO:0008173 RNA methyltransferase activity(GO:0008173)
1.3 6.7 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
1.3 16.0 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
1.3 6.6 GO:0003727 single-stranded RNA binding(GO:0003727)
1.3 4.0 GO:0004100 chitin synthase activity(GO:0004100)
1.3 261.6 GO:0003723 RNA binding(GO:0003723)
1.3 3.8 GO:0000146 microfilament motor activity(GO:0000146)
1.2 6.0 GO:0060590 ATPase regulator activity(GO:0060590)
1.2 15.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.2 4.7 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
1.2 3.5 GO:0008171 O-methyltransferase activity(GO:0008171)
1.1 9.0 GO:0019239 deaminase activity(GO:0019239)
1.1 4.5 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
1.1 25.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
1.0 12.5 GO:0005199 structural constituent of cell wall(GO:0005199)
1.0 11.3 GO:0070566 adenylyltransferase activity(GO:0070566)
1.0 8.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.0 5.0 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
1.0 3.0 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
1.0 5.9 GO:0004521 endoribonuclease activity(GO:0004521)
1.0 5.9 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
1.0 5.8 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.0 9.7 GO:0004177 aminopeptidase activity(GO:0004177)
1.0 12.4 GO:0042803 protein homodimerization activity(GO:0042803)
0.9 25.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.9 7.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.9 8.2 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.9 2.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.9 64.1 GO:0019001 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.9 8.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.8 0.8 GO:0019901 protein kinase binding(GO:0019901)
0.8 5.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.8 2.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.8 5.8 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.7 3.0 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.7 6.6 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.7 6.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.7 2.8 GO:0016885 biotin carboxylase activity(GO:0004075) ligase activity, forming carbon-carbon bonds(GO:0016885)
0.7 5.7 GO:0051087 chaperone binding(GO:0051087)
0.7 4.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.7 4.1 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.6 2.5 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.6 3.0 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.6 2.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.6 1.7 GO:0008144 drug binding(GO:0008144)
0.6 3.9 GO:0019211 phosphatase activator activity(GO:0019211)
0.6 1.7 GO:0003680 AT DNA binding(GO:0003680)
0.5 34.2 GO:0051082 unfolded protein binding(GO:0051082)
0.5 3.0 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.5 1.5 GO:0008252 nucleotidase activity(GO:0008252)
0.5 30.6 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.5 1.4 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.5 2.3 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.5 3.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.5 1.4 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.4 0.9 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.4 2.9 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.4 0.8 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.4 4.5 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.4 32.2 GO:0003682 chromatin binding(GO:0003682)
0.4 10.4 GO:0000287 magnesium ion binding(GO:0000287)
0.4 4.0 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
0.4 3.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.4 1.2 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.4 3.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.4 1.5 GO:0004771 sterol esterase activity(GO:0004771)
0.3 3.5 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.3 1.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 16.1 GO:0008565 protein transporter activity(GO:0008565)
0.3 1.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.3 1.6 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.3 1.9 GO:0004529 exodeoxyribonuclease activity(GO:0004529)
0.3 0.9 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.3 0.9 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.3 3.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 1.8 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.3 1.0 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.3 1.3 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.2 8.2 GO:0043130 ubiquitin binding(GO:0043130)
0.2 3.1 GO:0019207 kinase regulator activity(GO:0019207)
0.2 1.4 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.2 0.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 0.9 GO:0005034 osmosensor activity(GO:0005034)
0.2 5.6 GO:0004871 signal transducer activity(GO:0004871)
0.2 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.2 0.5 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.2 3.9 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.2 2.2 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 0.5 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) thiol oxidase activity(GO:0016972)
0.1 1.0 GO:0043566 structure-specific DNA binding(GO:0043566)
0.1 1.2 GO:0016866 intramolecular transferase activity(GO:0016866)
0.1 0.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 3.3 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 1.7 GO:0051287 NAD binding(GO:0051287)
0.1 0.6 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 2.2 GO:0042393 histone binding(GO:0042393)
0.1 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.4 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.1 0.3 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.1 0.3 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 0.3 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.5 GO:0030276 clathrin binding(GO:0030276)
0.1 1.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.4 GO:0003774 motor activity(GO:0003774)
0.0 0.1 GO:0003993 acid phosphatase activity(GO:0003993)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
9.1 27.2 PID LKB1 PATHWAY LKB1 signaling events
8.7 8.7 PID VEGFR1 PATHWAY VEGFR1 specific signals
4.3 13.0 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
3.5 14.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
3.0 8.9 PID SHP2 PATHWAY SHP2 signaling
2.6 26.2 PID ATR PATHWAY ATR signaling pathway
2.6 10.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
2.4 7.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
2.1 4.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
1.8 3.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
1.1 1.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.9 3.7 PID P73PATHWAY p73 transcription factor network
0.6 1.9 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.5 1.5 PID E2F PATHWAY E2F transcription factor network
0.2 1.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 1.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.2 0.6 PID MYC PATHWAY C-MYC pathway
0.2 0.6 PID AURORA B PATHWAY Aurora B signaling
0.1 0.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 21.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
6.5 52.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
6.2 18.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
5.9 23.5 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
5.2 36.3 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
4.4 13.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
4.2 67.1 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
3.8 7.7 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
3.6 10.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
3.5 14.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
3.1 9.3 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
2.5 17.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
2.5 17.3 REACTOME PROTEIN FOLDING Genes involved in Protein folding
2.2 10.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
1.9 7.7 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
1.7 3.4 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
1.4 8.7 REACTOME AXON GUIDANCE Genes involved in Axon guidance
1.4 8.2 REACTOME TRANSLATION Genes involved in Translation
1.2 4.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.1 2.3 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.9 6.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.8 0.8 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.5 2.2 REACTOME APOPTOSIS Genes involved in Apoptosis
0.5 7.2 REACTOME TRANSCRIPTION Genes involved in Transcription
0.5 0.9 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.3 3.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 3.0 REACTOME M G1 TRANSITION Genes involved in M/G1 Transition
0.2 0.5 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.1 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks