Results for SFP1
Z-value: 6.73
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Transcription factors associated with SFP1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SFP1
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S000004395 | Regulates transcription of ribosomal protein and biogenesis genes |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YHR094C Show fit | 86.95 |
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting |
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| YFR055W Show fit | 62.25 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YJL148W Show fit | 55.39 |
RNA polymerase I subunit A34.5 |
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| YFR056C Show fit | 54.46 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YDR345C Show fit | 48.39 |
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions |
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| YOR047C Show fit | 43.10 |
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p |
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| YLR372W Show fit | 37.44 |
Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis |
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| YAL038W Show fit | 36.13 |
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration |
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| YPL037C Show fit | 34.33 |
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b |
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| YJR070C Show fit | 33.63 |
Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning |
Network of associatons between targets according to the STRING database.
First level regulatory network of SFP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 397.4 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 5.5 | 247.5 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 4.5 | 241.0 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 6.3 | 195.9 | GO:0034471 | rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471) |
| 5.7 | 186.7 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 5.6 | 172.5 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 7.7 | 138.0 | GO:0042790 | transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790) |
| 7.5 | 134.7 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 6.8 | 121.8 | GO:0042797 | tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 4.1 | 111.0 | GO:0033750 | ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 456.3 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 2.6 | 307.1 | GO:0005730 | nucleolus(GO:0005730) |
| 6.3 | 295.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 5.1 | 260.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 14.1 | 197.5 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 4.8 | 149.4 | GO:0030684 | preribosome(GO:0030684) |
| 5.2 | 134.8 | GO:0032040 | small-subunit processome(GO:0032040) |
| 16.9 | 67.5 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 9.1 | 63.7 | GO:0034455 | t-UTP complex(GO:0034455) |
| 15.8 | 63.4 | GO:0031429 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 619.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.3 | 261.6 | GO:0003723 | RNA binding(GO:0003723) |
| 14.1 | 197.5 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 5.1 | 159.6 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 7.3 | 146.7 | GO:0030515 | snoRNA binding(GO:0030515) |
| 4.3 | 126.0 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 6.6 | 98.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 2.7 | 71.9 | GO:0008135 | translation factor activity, RNA binding(GO:0008135) |
| 0.9 | 64.1 | GO:0019001 | GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561) |
| 1.8 | 62.6 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.1 | 27.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 2.6 | 26.2 | PID ATR PATHWAY | ATR signaling pathway |
| 3.5 | 14.0 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 4.3 | 13.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 2.6 | 10.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 3.0 | 8.9 | PID SHP2 PATHWAY | SHP2 signaling |
| 8.7 | 8.7 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 2.4 | 7.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 2.1 | 4.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.8 | 3.7 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 67.1 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 6.5 | 52.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 5.2 | 36.3 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 5.9 | 23.5 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 7.1 | 21.2 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 6.2 | 18.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 2.5 | 17.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 2.5 | 17.3 | REACTOME PROTEIN FOLDING | Genes involved in Protein folding |
| 3.5 | 14.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 4.4 | 13.2 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |