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Results for SMP1

Z-value: 0.58

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Transcription factors associated with SMP1

Gene Symbol Gene ID Gene Info
SMP1
S000000386 Putative transcription factor of the MADS-box family

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMP1YBR182C-0.832.0e-07Click!

Activity profile of SMP1 motif

Sorted Z-values of SMP1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YDR098C 4.27
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YLR154C 2.69
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YJR094W-A 2.65
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YLR388W 2.51
RPS29A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YLR154W-B 2.22 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YHR181W 2.21
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YEL040W 2.18
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YLR154W-A 2.16 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YPR157W 2.10 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR116C 2.10
ASC1
G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
YDR417C 2.09 Hypothetical protein
YIL096C 1.98 Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit
YHR180W-A 1.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YNL162W 1.78
RPL42A
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein
YKL164C 1.73
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YOR063W 1.69
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YLR154W-C 1.68
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YPL273W 1.67
SAM4
S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YNR001W-A 1.67 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YMR142C 1.54
RPL13B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YDL055C 1.49
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YMR143W 1.48
RPS16A
Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YGL031C 1.46
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YDR033W 1.36
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YGR085C 1.25
RPL11B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YMR303C 1.25
ADH2
Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
YGL030W 1.20
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YMR290C 1.18
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YMR241W 1.17
YHM2
Mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family
YDL241W 1.16 Putative protein of unknown function; YDL241W is not an essential gene
YGR271C-A 1.15
EFG1
Protein of unknown function; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YNL182C 1.14
IPI3
Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YKL218C 1.13
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YBR092C 1.13
PHO3
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YMR290W-A 1.12 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YLR432W 1.12
IMD3
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YML073C 1.11
RPL6A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
YDR509W 1.11 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR191W 1.11
RPL21A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein
YIL052C 1.10
RPL34B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YML063W 1.08
RPS1B
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YDR508C 1.07
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YML075C 1.06
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YKL219W 1.04
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YOL086C 1.04
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YPR010C 1.03
RPA135
RNA polymerase I subunit A135
YGR148C 1.03
RPL24B
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YHR141C 1.02
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YGR035C 0.96 Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YMR217W 0.96
GUA1
GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YER007C-A 0.95
TMA20
Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1
YJL162C 0.93
JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YMR246W 0.92
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YFR055W 0.91
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YDR041W 0.90
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YLL044W 0.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
YOR046C 0.88
DBP5
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination
YFL022C 0.86
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YLR048W 0.84
RPS0B
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YOR096W 0.84
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YOR073W-A 0.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR
YGR090W 0.83
UTP22
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YER026C 0.83
CHO1
Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
YKR094C 0.83
RPL40B
Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YML071C 0.83
COG8
Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YER137C 0.82 Putative protein of unknown function
YLR257W 0.82 Putative protein of unknown function
YJL115W 0.81
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YKR013W 0.81
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YML074C 0.80
FPR3
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YOR320C 0.79
GNT1
N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus
YMR106C 0.78
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YFR056C 0.77 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YLR196W 0.77
PWP1
Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YGR040W 0.77
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YLR453C 0.77
RIF2
Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YOR074C 0.77
CDC21
Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YDR040C 0.76
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YML043C 0.76
RRN11
Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YPL160W 0.75
CDC60
Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
YPL037C 0.75
EGD1
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YOR169C 0.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W
YDL179W 0.73
PCL9
Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
YIL148W 0.73
RPL40A
Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YGR036C 0.72
CAX4
Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YBR104W 0.72
YMC2
Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YOL039W 0.72
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YCR004C 0.71
YCP4
Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR102W-A 0.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR123W 0.70
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YOL013W-A 0.70 Putative protein of unknown function; identified by SAGE
YAL059W 0.70
ECM1
Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export
YDL047W 0.70
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YER131W 0.68
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YNR054C 0.67
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YDR531W 0.67 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YKR003W 0.67
OSH6
Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery
YBL108W 0.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR158W 0.67
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YLR191W 0.66
PEX13
Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
YOL040C 0.66
RPS15
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YNL178W 0.65
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YKR012C 0.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YPL030W 0.65
TRM44
tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
YCL022C 0.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W
YGR285C 0.64
ZUO1
Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
YHL001W 0.63
RPL14B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein
YPL108W 0.63 Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YNR061C 0.63 Putative protein of unknown function
YIL118W 0.63
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YFR037C 0.63
RSC8
Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YNL058C 0.62 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene
YHR052W 0.62
CIC1
Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
YJR063W 0.62
RPA12
RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
YLR028C 0.62
ADE16
Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine
YLR060W 0.61
FRS1
Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; sequence is evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase (Msf1p), but substrate binding is similar
YOR133W 0.61
EFT1
Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YIR021W 0.61
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YML119W 0.60 Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YLR441C 0.60
RPS1A
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
YOR309C 0.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
YDL240W 0.59
LRG1
Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YDL143W 0.59
CCT4
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YDR226W 0.59
ADK1
Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence
YLR076C 0.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
YLR025W 0.58
SNF7
One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
YOR340C 0.58
RPA43
RNA polymerase I subunit A43
YDL211C 0.58 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YDL167C 0.57
NRP1
Protein of unknown function, rich in asparagine residues
YIL018W 0.57
RPL2B
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures
YAL029C 0.57
MYO4
One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
YMR099C 0.56 Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
YNL175C 0.55
NOP13
Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA
YPR079W 0.55
MRL1
Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases
YNL057W 0.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR004W 0.54
PEX31
Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
YOL101C 0.54
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YBR084C-A 0.51
RPL19A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YIL029C 0.51 Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YBL087C 0.51
RPL23A
Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
YBR181C 0.50
RPS6B
Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YGR251W 0.50 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YML065W 0.50
ORC1
Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
YHR094C 0.49
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YMR141W-A 0.49 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C
YGR159C 0.49
NSR1
Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YML022W 0.49
APT1
Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis
YDR023W 0.49
SES1
Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YDR450W 0.48
RPS18A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YNL189W 0.48
SRP1
Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
YDL081C 0.48
RPP1A
Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
YJL011C 0.48
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YDR050C 0.48
TPI1
Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
YJL169W 0.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
YOR293W 0.48
RPS10A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
YNL090W 0.47
RHO2
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YGL158W 0.47
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YBR048W 0.47
RPS11B
Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YEL068C 0.47 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR216W 0.46
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YCL018W 0.46
LEU2
Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YIL169C 0.46 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YKL068W-A 0.46 Putative protein of unknown function; identified by homology to Ashbya gossypii
YMR100W 0.45
MUB1
Protein of unknown function, deletion causes multi-budding phenotype; has similarity to Aspergillus nidulans samB gene
YLL012W 0.45
YEH1
Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
YIR042C 0.45 Putative protein of unknown function; YIR042C is a non-essential gene
YHR021C 0.45
RPS27B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YMR205C 0.45
PFK2
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YOR241W 0.45
MET7
Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA
YOR357C 0.44
SNX3
Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
YDR326C 0.44
YSP2
Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification
YOR376W-A 0.44 Putative protein of unknown function; identified by fungal homology and RT-PCR
YNL043C 0.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YPR119W 0.44
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YNR003C 0.44
RPC34
RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YPL146C 0.44
NOP53
Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
YGR018C 0.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR017W
YCR102C 0.43 Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene
YAR002W 0.43
NUP60
Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
YFR032C 0.43 Putative protein of unknown function; transcribed during sporulation; YFR032C is not an essential gene
YBR190W 0.43 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
YJL190C 0.43
RPS22A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YGL224C 0.43
SDT1
Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
YBR267W 0.43
REI1
Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
YHR043C 0.43
DOG2
2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
YOR385W 0.42 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene
YNR072W 0.42
HXT17
Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YGR035W-A 0.42 Putative protein of unknown function
YAL007C 0.42
ERP2
Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YGR108W 0.42
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YGR034W 0.41
RPL26B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YMR123W 0.41
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YCR034W 0.40
FEN1
Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YMR304C-A 0.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10
YHR005C 0.40
GPA1
GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome
YKL063C 0.40 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YBR085W 0.40
AAC3
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YPL250W-A 0.40 Identified by fungal homology and RT-PCR
YDR099W 0.40
BMH2
14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YLR129W 0.40
DIP2
Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex

Network of associatons between targets according to the STRING database.

First level regulatory network of SMP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.5 1.6 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.5 1.5 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.5 1.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.4 1.7 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.4 2.9 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.4 1.2 GO:0048024 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
0.4 1.9 GO:0009757 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.4 1.1 GO:0032006 regulation of TOR signaling(GO:0032006)
0.3 1.0 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.3 1.0 GO:0006177 GMP biosynthetic process(GO:0006177) guanosine-containing compound biosynthetic process(GO:1901070)
0.3 5.5 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.3 0.9 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.3 0.3 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.3 0.8 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.3 1.1 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.3 0.8 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.2 1.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 1.7 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.2 1.0 GO:0015909 long-chain fatty acid transport(GO:0015909) fatty-acyl-CoA metabolic process(GO:0035337)
0.2 1.0 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 2.2 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
0.2 33.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 2.5 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.2 1.5 GO:0043457 regulation of cellular respiration(GO:0043457)
0.2 0.6 GO:0048211 Golgi vesicle docking(GO:0048211)
0.2 3.3 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.2 0.4 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.2 0.6 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.2 0.8 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.2 2.5 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 0.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.2 0.9 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.2 0.8 GO:0017157 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.2 0.5 GO:0044209 purine nucleobase salvage(GO:0043096) AMP salvage(GO:0044209) adenine metabolic process(GO:0046083)
0.2 0.6 GO:0030497 fatty acid elongation(GO:0030497)
0.2 0.8 GO:0007535 donor selection(GO:0007535)
0.2 1.4 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.2 1.1 GO:0043102 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.1 0.4 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.1 0.4 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 1.2 GO:0000080 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318)
0.1 1.0 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.1 1.0 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.6 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1 3.8 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 0.4 GO:0071044 histone mRNA metabolic process(GO:0008334) histone mRNA catabolic process(GO:0071044)
0.1 0.3 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.1 0.8 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.1 0.6 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.1 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.1 0.1 GO:0071482 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.1 0.3 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.1 1.9 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 0.2 GO:0050000 telomere localization(GO:0034397) chromosome localization(GO:0050000)
0.1 0.8 GO:0046040 IMP biosynthetic process(GO:0006188) 'de novo' IMP biosynthetic process(GO:0006189) IMP metabolic process(GO:0046040)
0.1 0.4 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.1 0.4 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.1 0.8 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.4 GO:0015886 heme transport(GO:0015886)
0.1 0.6 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.1 0.2 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 0.3 GO:0032239 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.1 0.4 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 0.4 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 0.4 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.1 1.7 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.3 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.1 0.6 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.1 0.3 GO:0000296 spermine transport(GO:0000296)
0.1 1.1 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 0.3 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 0.3 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.7 GO:0033313 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.1 0.9 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.1 0.2 GO:0042990 regulation of transcription factor import into nucleus(GO:0042990)
0.1 0.2 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 0.4 GO:0055088 lipid homeostasis(GO:0055088)
0.1 2.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.2 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.1 0.1 GO:2001021 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.1 0.4 GO:0006551 leucine metabolic process(GO:0006551)
0.1 0.9 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.3 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.1 0.3 GO:0009099 valine biosynthetic process(GO:0009099)
0.1 0.3 GO:1902750 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) negative regulation of cell cycle G2/M phase transition(GO:1902750)
0.1 1.7 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 0.2 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.1 0.6 GO:0016233 telomere capping(GO:0016233)
0.1 0.6 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.1 1.1 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.1 1.2 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.1 0.9 GO:0006415 translational termination(GO:0006415)
0.1 1.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 1.7 GO:0046939 nucleotide phosphorylation(GO:0046939)
0.1 0.1 GO:0060988 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.6 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 0.1 GO:0006048 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.3 GO:0030030 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
0.1 0.2 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.1 0.3 GO:0006448 regulation of translational elongation(GO:0006448)
0.1 0.2 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.1 0.2 GO:0035950 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.1 0.2 GO:0032211 negative regulation of telomere maintenance(GO:0032205) negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of homeostatic process(GO:0032845) negative regulation of telomere maintenance via telomere lengthening(GO:1904357) negative regulation of DNA biosynthetic process(GO:2000279)
0.1 0.2 GO:0001510 RNA methylation(GO:0001510)
0.1 0.2 GO:0000771 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.1 0.3 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.1 0.1 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472)
0.1 0.4 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 0.4 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 0.7 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 0.1 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0 0.2 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0008216 spermidine metabolic process(GO:0008216)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.6 GO:0007120 axial cellular bud site selection(GO:0007120)
0.0 0.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.3 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.5 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.5 GO:0009303 rRNA transcription(GO:0009303)
0.0 2.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.1 GO:0043902 positive regulation of multi-organism process(GO:0043902)
0.0 0.8 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.0 0.3 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.1 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.1 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.1 GO:0015867 ATP transport(GO:0015867)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.0 GO:0051196 regulation of nucleoside metabolic process(GO:0009118) regulation of nucleotide catabolic process(GO:0030811) regulation of cofactor metabolic process(GO:0051193) regulation of coenzyme metabolic process(GO:0051196) regulation of ATP metabolic process(GO:1903578)
0.0 0.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.5 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.2 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.1 GO:0000092 mitotic anaphase B(GO:0000092)
0.0 0.1 GO:1901073 aminoglycan biosynthetic process(GO:0006023) chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.0 4.2 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.3 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.1 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.4 GO:0006414 translational elongation(GO:0006414)
0.0 0.2 GO:0097502 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0 0.1 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362) regulation of transcription-coupled nucleotide-excision repair(GO:0090262) regulation of nucleotide-excision repair(GO:2000819) regulation of histone H2B ubiquitination(GO:2001166) regulation of histone H2B conserved C-terminal lysine ubiquitination(GO:2001173) regulation of transcription elongation from RNA polymerase I promoter(GO:2001207) positive regulation of transcription elongation from RNA polymerase I promoter(GO:2001209)
0.0 0.9 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.1 GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035)
0.0 0.1 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.0 0.3 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.3 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.5 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.6 GO:0006614 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.3 GO:0042181 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.2 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.2 GO:0000162 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.0 0.5 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 1.6 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.3 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.2 GO:0032042 mitochondrial DNA metabolic process(GO:0032042)
0.0 0.0 GO:0043038 amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)
0.0 0.2 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.0 GO:0007232 osmosensory signaling pathway via Sho1 osmosensor(GO:0007232)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.0 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.0 0.5 GO:0006612 protein targeting to membrane(GO:0006612)
0.0 0.3 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.3 GO:0006284 base-excision repair(GO:0006284)
0.0 0.1 GO:0007030 Golgi organization(GO:0007030)
0.0 0.0 GO:0043470 regulation of carbohydrate catabolic process(GO:0043470) regulation of cellular carbohydrate catabolic process(GO:0043471)
0.0 0.3 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.0 0.1 GO:0034517 ribophagy(GO:0034517)
0.0 0.0 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
0.0 0.2 GO:0015918 sterol transport(GO:0015918)
0.0 0.1 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.0 0.5 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.0 0.0 GO:0000200 inactivation of MAPK activity(GO:0000188) inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) negative regulation of MAP kinase activity(GO:0043407) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.0 0.2 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.4 GO:0051647 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.0 0.1 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.0 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.2 GO:0044089 positive regulation of cellular component biogenesis(GO:0044089)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.1 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.1 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133) regulation of cellular amine catabolic process(GO:0033241)
0.0 0.6 GO:0008202 steroid metabolic process(GO:0008202) sterol metabolic process(GO:0016125)
0.0 0.2 GO:0000105 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.0 0.0 GO:0070786 positive regulation of cell growth(GO:0030307) positive regulation of growth of unicellular organism as a thread of attached cells(GO:0070786) positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter(GO:1900461) positive regulation of pseudohyphal growth(GO:2000222)
0.0 0.1 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.1 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.2 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.0 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.0 0.2 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.0 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.0 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.0 0.0 GO:0051225 spindle assembly(GO:0051225)
0.0 0.0 GO:2000221 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.0 0.2 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.1 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.0 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.1 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.0 0.0 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.0 0.1 GO:0007009 plasma membrane organization(GO:0007009)
0.0 0.0 GO:0000076 DNA replication checkpoint(GO:0000076)
0.0 0.1 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.0 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.0 0.1 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.0 0.1 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.0 GO:0060195 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.0 0.1 GO:0043555 regulation of translation in response to stress(GO:0043555)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.4 1.1 GO:0097344 Rix1 complex(GO:0097344)
0.3 1.0 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.3 1.0 GO:0070545 PeBoW complex(GO:0070545)
0.3 26.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 17.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 1.1 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.2 2.2 GO:0000144 cellular bud neck septin ring(GO:0000144)
0.2 3.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 0.8 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.2 0.8 GO:0005797 Golgi medial cisterna(GO:0005797)
0.2 0.8 GO:0042597 periplasmic space(GO:0042597)
0.2 0.9 GO:0032545 CURI complex(GO:0032545)
0.2 0.6 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.0 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.6 GO:0000815 ESCRT III complex(GO:0000815)
0.1 1.0 GO:0017119 Golgi transport complex(GO:0017119)
0.1 2.8 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 0.7 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 1.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.4 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.1 0.3 GO:0005845 mRNA cap binding complex(GO:0005845)
0.1 0.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.2 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.6 GO:0016459 myosin complex(GO:0016459)
0.1 1.4 GO:0034399 nuclear periphery(GO:0034399)
0.1 3.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.6 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.4 GO:0005940 septin ring(GO:0005940)
0.1 0.4 GO:0031985 Golgi cisterna(GO:0031985)
0.1 0.3 GO:0033551 monopolin complex(GO:0033551)
0.1 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.4 GO:0031499 TRAMP complex(GO:0031499)
0.1 0.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 1.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.9 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.9 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.3 GO:0070772 PAS complex(GO:0070772)
0.1 0.1 GO:0000133 polarisome(GO:0000133)
0.1 1.4 GO:0005844 polysome(GO:0005844)
0.1 0.2 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.3 GO:0005871 kinesin complex(GO:0005871)
0.1 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.3 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.4 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.3 GO:0005880 nuclear microtubule(GO:0005880)
0.0 0.5 GO:0005791 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.2 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.3 GO:0031933 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.0 7.6 GO:0005730 nucleolus(GO:0005730)
0.0 0.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.0 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.0 0.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663) Elg1 RFC-like complex(GO:0031391)
0.0 0.2 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 1.2 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.7 GO:0016586 RSC complex(GO:0016586)
0.0 0.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.0 0.1 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 0.4 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 0.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.8 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0000346 transcription export complex(GO:0000346)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.1 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.0 0.1 GO:0016587 Isw1 complex(GO:0016587)
0.0 0.2 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 4.1 GO:0005933 cellular bud(GO:0005933)
0.0 0.1 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.0 0.1 GO:0034044 exomer complex(GO:0034044)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.1 GO:0071819 DUBm complex(GO:0071819)
0.0 0.0 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.4 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.6 GO:0043332 mating projection tip(GO:0043332)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.5 GO:0030659 vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659)
0.0 0.0 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.6 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.5 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.0 GO:0051233 spindle midzone(GO:0051233)
0.0 0.0 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.0 0.0 GO:0043625 delta DNA polymerase complex(GO:0043625)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.5 1.6 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.5 1.6 GO:0070568 guanylyltransferase activity(GO:0070568)
0.5 1.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.5 2.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.4 1.7 GO:0008172 S-methyltransferase activity(GO:0008172)
0.4 2.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 1.2 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.3 1.1 GO:0016854 ammonia-lyase activity(GO:0016841) racemase and epimerase activity(GO:0016854)
0.3 0.8 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.3 1.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.3 0.8 GO:0001187 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
0.2 1.5 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 1.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 3.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 0.7 GO:0043325 phosphatidylinositol-5-phosphate binding(GO:0010314) phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 2.2 GO:0031386 protein tag(GO:0031386)
0.2 3.3 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.2 0.8 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 38.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 0.8 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.2 1.8 GO:0043178 alcohol binding(GO:0043178)
0.2 0.5 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 0.8 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.4 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.1 0.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 0.4 GO:0009922 fatty acid elongase activity(GO:0009922)
0.1 0.6 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 0.6 GO:0000146 microfilament motor activity(GO:0000146)
0.1 0.5 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.1 0.6 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 1.1 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.8 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.1 0.4 GO:0008252 nucleotidase activity(GO:0008252)
0.1 0.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.4 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.1 0.4 GO:0004771 sterol esterase activity(GO:0004771)
0.1 0.3 GO:0004100 chitin synthase activity(GO:0004100)
0.1 1.1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.3 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 0.6 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.3 GO:0000339 RNA cap binding(GO:0000339)
0.1 0.3 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.1 0.7 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.1 0.3 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.2 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.1 0.2 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.1 0.5 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.1 1.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 1.3 GO:0019843 rRNA binding(GO:0019843)
0.1 0.4 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.2 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 0.1 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.1 0.2 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.1 0.1 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.1 0.3 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.6 GO:0005516 calmodulin binding(GO:0005516)
0.1 1.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.3 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 2.3 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.6 GO:0010181 FMN binding(GO:0010181)
0.1 0.9 GO:0030515 snoRNA binding(GO:0030515)
0.1 0.2 GO:0016504 peptidase activator activity(GO:0016504)
0.1 1.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.3 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.7 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.1 0.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 0.2 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.5 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.1 1.3 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 1.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.1 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.0 0.2 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.2 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0070717 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.0 1.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.7 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.3 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 1.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 1.4 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.2 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.1 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.0 0.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0016408 C-acyltransferase activity(GO:0016408)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.1 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.2 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.3 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0004529 exodeoxyribonuclease activity(GO:0004529)
0.0 1.6 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0004000 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.0 0.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.0 1.6 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.6 GO:0005048 signal sequence binding(GO:0005048)
0.0 0.2 GO:0001016 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III regulatory region DNA binding(GO:0001016) RNA polymerase III type 1 promoter DNA binding(GO:0001030) transcription factor activity, RNA polymerase III transcription factor recruiting(GO:0001153) 5S rDNA binding(GO:0080084)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.2 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 3.8 GO:0003723 RNA binding(GO:0003723)
0.0 0.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.5 GO:0003779 actin binding(GO:0003779)
0.0 0.1 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.0 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0019207 kinase regulator activity(GO:0019207)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.0 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.3 GO:0000030 mannosyltransferase activity(GO:0000030)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 PID SHP2 PATHWAY SHP2 signaling
0.3 1.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 0.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 0.7 PID E2F PATHWAY E2F transcription factor network
0.1 0.1 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 0.4 PID P73PATHWAY p73 transcription factor network
0.1 0.1 PID FGF PATHWAY FGF signaling pathway
0.1 0.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.1 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.2 PID ATR PATHWAY ATR signaling pathway
0.0 0.0 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.3 2.3 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.2 3.9 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.2 0.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 0.8 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.2 0.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 0.6 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.1 0.7 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 0.1 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 0.2 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.3 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
0.0 0.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.1 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME AXON GUIDANCE Genes involved in Axon guidance
0.0 0.1 REACTOME APOPTOSIS Genes involved in Apoptosis
0.0 0.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation