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Results for STB4

Z-value: 1.42

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Transcription factors associated with STB4

Gene Symbol Gene ID Gene Info
STB4
S000004621 Putative transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STB4YMR019W0.442.3e-02Click!

Activity profile of STB4 motif

Sorted Z-values of STB4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YKR097W 15.58
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YNL117W 10.63
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YPL262W 8.48
FUM1
Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YMR081C 7.26
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YLR307C-A 7.21 Putative protein of unknown function
YER024W 7.00
YAT2
Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YJR078W 6.34
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YMR034C 5.38 Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
YBR072W 5.19
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YGR067C 4.97 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YJR146W 4.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YLR122C 4.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YIL057C 4.61 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YBR222C 4.48
PCS60
Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
YDR406W 4.44
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YNL144C 4.37 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YJR155W 4.35
AAD10
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YER065C 4.35
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YBR051W 4.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YBR050C 4.30
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YLL060C 4.30
GTT2
Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YAL062W 4.28
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YGL255W 4.22
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YMR271C 4.16
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YLL053C 4.15 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YLR123C 3.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YDL169C 3.89
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YPL054W 3.86
LEE1
Zinc-finger protein of unknown function
YPR002W 3.83
PDH1
Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YJR077C 3.79
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YLL052C 3.67
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YGL184C 3.67
STR3
Cystathionine beta-lyase, converts cystathionine into homocysteine
YAR023C 3.62 Putative integral membrane protein, member of DUP240 gene family
YIL166C 3.57 Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
YLR312C 3.34
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YEL028W 3.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR296W 3.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR006C 3.32
ICL2
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YOR208W 3.31
PTP2
Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus
YGL208W 3.28
SIP2
One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
YKL065W-A 3.17 Putative protein of unknown function
YFL055W 3.17
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YMR056C 3.11
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YNR073C 3.08 Putative mannitol dehydrogenase
YBR047W 3.06
FMP23
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR295C 3.05
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YHR048W 3.04
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YJR120W 3.03 Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YOR147W 3.03
MDM32
Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YFR022W 3.03
ROG3
Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YNL142W 3.01
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YOR343C 3.00 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDR343C 2.97
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YBR045C 2.90
GIP1
Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
YFL024C 2.79
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YOL154W 2.73
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YDL170W 2.72
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YKR067W 2.70
GPT2
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YMR035W 2.66
IMP2
Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
YPL223C 2.65
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YBR046C 2.64
ZTA1
Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
YML089C 2.61 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YLR125W 2.55 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YKR066C 2.55
CCP1
Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YCL040W 2.55
GLK1
Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YAR050W 2.51
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YLR124W 2.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL023C 2.44
YKE4
Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
YBL015W 2.43
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YDR102C 2.43 Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YGR065C 2.40
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YPL021W 2.38
ECM23
Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
YCL042W 2.38 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YAR053W 2.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL102W 2.34
SFT2
Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
YGR023W 2.33
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YLR252W 2.30 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism
YDR421W 2.29
ARO80
Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
YPR010C-A 2.28 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YPR184W 2.27
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YFL052W 2.25 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YDR533C 2.23
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YJR150C 2.23
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YGR022C 2.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YBL043W 2.18
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YJL116C 2.15
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YPL024W 2.14
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YGL083W 2.12
SCY1
Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
YHR092C 2.10
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YJR147W 2.10
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YHL046W-A 2.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAR047C 2.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR124W 2.08 Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
YKL162C 2.06 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YDR505C 2.06
PSP1
Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition
YBL030C 2.06
PET9
Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
YGL165C 2.05 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
YEL020C 2.04 Hypothetical protein with low sequence identity to Pdc1p
YDR148C 2.03
KGD2
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
YNL274C 2.03
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR015C 2.02 Putative protein of unknown function
YLR326W 1.99 Hypothetical protein
YMR206W 1.99 Putative protein of unknown function; YMR206W is not an essential gene
YPL222C-A 1.99 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPR140W 1.99
TAZ1
Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; similar to human tafazzin, which is implicated in Barth syndrome
YBR067C 1.98
TIP1
Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YBR296C 1.94
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YDR103W 1.90
STE5
Pheromone-response scaffold protein; binds kinases Ste11p, Ste7p, and Fus3p to form a MAPK cascade complex that interacts with the plasma membrane, via a PH (pleckstrin homology) and PM/NLS domain, and with Ste4p-Ste18p, during signaling
YAR060C 1.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR393W 1.88
ATP10
Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
YEL049W 1.87
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YNL134C 1.85 Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YHL047C 1.85
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YNL036W 1.85
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YMR110C 1.84
HFD1
Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome
YLR402W 1.83 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR005C 1.80
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YJR020W 1.80 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR110W 1.78 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YLR403W 1.78
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YNL143C 1.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR277C 1.78
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YJR046W 1.77
TAH11
DNA replication licensing factor, required for pre-replication complex assembly
YGL131C 1.77
SNT2
DNA binding protein with similarity to the S. pombe Snt2 protein
YDR536W 1.76
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YJR019C 1.75
TES1
Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
YKR102W 1.73
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YER033C 1.73
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YGL084C 1.72
GUP1
Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport
YJR045C 1.70
SSC1
Mitochondrial matrix ATPase, subunit of the presequence translocase-associated protein import motor (PAM) and of SceI endonuclease; involved in protein folding and translocation into the matrix; phosphorylated; member of HSP70 family
YAR035W 1.67
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YMR103C 1.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR178C 1.67
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YDR298C 1.66
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YLR342W 1.66
FKS1
Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
YBL017C 1.66
PEP1
Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
YDR043C 1.66
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YNL115C 1.65 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
YOR023C 1.64
AHC1
Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
YOR231W 1.62
MKK1
Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p
YIL125W 1.61
KGD1
Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YOR378W 1.60 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YDR178W 1.59
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YNR034W-A 1.58 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YDR542W 1.56
PAU10
Hypothetical protein
YAR027W 1.55
UIP3
Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
YBR077C 1.55
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YIL042C 1.54
PKP1
Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
YHR159W 1.52 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate
YML090W 1.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YER066W 1.51 Putative protein of unknown function; YER066W is not an essential gene
YLR304C 1.46
ACO1
Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YFR023W 1.46
PES4
Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
YKR016W 1.46
AIM28
Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media
YFR053C 1.45
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YHL021C 1.44
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YPL026C 1.44
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YLR297W 1.43 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YPR196W 1.43 Putative maltose activator
YCR068W 1.42
ATG15
Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YOL128C 1.42
YGK3
Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YER150W 1.40
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YFR033C 1.40
QCR6
Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YJL100W 1.40
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YAL067C 1.39
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YLR294C 1.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
YMR316C-B 1.34 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR293W 1.34
VBA2
Permease of basic amino acids in the vacuolar membrane
YDR014W-A 1.34
HED1
Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YPL183W-A 1.32
RTC6
Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome; null mutation suppresses cdc13-1 temperature sensitivity
YPL111W 1.32
CAR1
Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YML054C 1.31
CYB2
Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YPR191W 1.30
QCR2
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YOL082W 1.30
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YDR387C 1.29 Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
YOR387C 1.29 Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YKL163W 1.28
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YOR142W 1.27
LSC1
Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
YBR284W 1.26 Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YGL134W 1.25
PCL10
Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
YIL162W 1.25
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YBR292C 1.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YOL051W 1.23
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YNR055C 1.23
HOL1
Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake
YLL055W 1.22
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YMR317W 1.22 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YOR394W 1.20
PAU21
Hypothetical protein
YLR047C 1.19
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YMR194C-B 1.19 Putative protein of unknown function
YPL222W 1.18
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL174C 1.18
DLD1
D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YDR541C 1.18 Putative dihydrokaempferol 4-reductase
YPL274W 1.18
SAM3
High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YKL141W 1.17
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YOR024W 1.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR212C 1.15 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR281C 1.14
PHM6
Protein of unknown function, expression is regulated by phosphate levels
YMR171C 1.13
EAR1
Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p: YMR171C is not an essential gene
YPL171C 1.12
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YLR035C 1.12
MLH2
Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p

Network of associatons between targets according to the STRING database.

First level regulatory network of STB4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.7 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
2.4 7.2 GO:0019543 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.9 18.8 GO:0046487 glyoxylate metabolic process(GO:0046487)
1.4 7.1 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
1.3 5.2 GO:0015886 heme transport(GO:0015886)
1.1 19.2 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
1.0 3.1 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.0 3.0 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.0 5.9 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.9 3.7 GO:0019346 transsulfuration(GO:0019346)
0.9 0.9 GO:0046185 aldehyde catabolic process(GO:0046185)
0.9 2.7 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.8 2.5 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.8 3.4 GO:0015976 carbon utilization(GO:0015976)
0.8 3.3 GO:1903137 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.8 3.2 GO:0046323 glucose import(GO:0046323)
0.8 2.3 GO:0006572 tyrosine catabolic process(GO:0006572)
0.8 6.8 GO:0006829 zinc II ion transport(GO:0006829)
0.7 2.7 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.7 0.7 GO:0035786 protein complex oligomerization(GO:0035786)
0.7 19.1 GO:0006094 gluconeogenesis(GO:0006094)
0.6 2.6 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.6 3.7 GO:0042407 cristae formation(GO:0042407)
0.6 2.5 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.6 1.7 GO:0015888 thiamine transport(GO:0015888)
0.6 1.7 GO:0043335 protein unfolding(GO:0043335)
0.6 1.7 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.6 2.8 GO:0051180 vitamin transport(GO:0051180)
0.5 2.7 GO:0015793 glycerol transport(GO:0015793)
0.5 2.1 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.5 2.7 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.5 4.4 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.5 1.4 GO:0036257 multivesicular body organization(GO:0036257)
0.5 2.4 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.5 1.8 GO:0019748 secondary metabolic process(GO:0019748)
0.5 2.3 GO:0005980 glycogen catabolic process(GO:0005980)
0.4 1.3 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.4 1.3 GO:0019627 urea metabolic process(GO:0019627)
0.4 1.3 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.4 1.2 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.4 1.2 GO:0000101 sulfur amino acid transport(GO:0000101)
0.4 2.0 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.4 4.4 GO:0015893 drug transport(GO:0015893)
0.4 0.8 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.4 1.1 GO:0005993 trehalose catabolic process(GO:0005993)
0.4 2.3 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.4 2.6 GO:0006083 acetate metabolic process(GO:0006083)
0.4 2.6 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.4 11.6 GO:0098656 anion transmembrane transport(GO:0098656)
0.4 3.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.4 1.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.4 4.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.3 2.0 GO:0044205 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.3 0.3 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.3 2.3 GO:0015758 glucose transport(GO:0015758)
0.3 1.9 GO:0006089 lactate metabolic process(GO:0006089)
0.3 0.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.3 1.9 GO:0015802 basic amino acid transport(GO:0015802)
0.3 0.9 GO:0034090 maintenance of meiotic sister chromatid cohesion(GO:0034090)
0.3 0.6 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.3 12.6 GO:0009060 aerobic respiration(GO:0009060)
0.3 2.2 GO:0070272 proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.3 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.3 0.8 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.3 2.6 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 0.8 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.3 0.5 GO:0006013 mannose metabolic process(GO:0006013)
0.2 1.0 GO:0000431 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.2 1.5 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.2 1.0 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 1.0 GO:0090337 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.2 1.2 GO:0000023 maltose metabolic process(GO:0000023)
0.2 0.5 GO:0006754 ATP biosynthetic process(GO:0006754)
0.2 1.4 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.2 0.7 GO:0006545 glycine biosynthetic process(GO:0006545)
0.2 0.7 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.2 0.6 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.2 0.8 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.2 0.6 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.2 0.6 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.2 0.6 GO:0008216 spermidine metabolic process(GO:0008216)
0.2 0.4 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.2 2.1 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.2 1.5 GO:0006573 valine metabolic process(GO:0006573)
0.2 0.7 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.2 5.2 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.2 0.7 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.2 1.4 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.2 0.2 GO:0007032 endosome organization(GO:0007032)
0.2 1.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.2 0.5 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.2 2.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.2 0.6 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.2 0.2 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.2 0.5 GO:0032006 regulation of TOR signaling(GO:0032006)
0.2 1.1 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.1 0.4 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 0.7 GO:0051274 beta-glucan biosynthetic process(GO:0051274)
0.1 0.3 GO:0051098 regulation of binding(GO:0051098)
0.1 1.7 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 1.0 GO:0033993 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.1 0.3 GO:0000304 response to singlet oxygen(GO:0000304)
0.1 0.4 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.1 0.4 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071) positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 0.6 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.4 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.1 0.4 GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238)
0.1 0.5 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.1 0.2 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.1 0.4 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.1 1.8 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 1.4 GO:0001101 response to acid chemical(GO:0001101)
0.1 3.2 GO:0051646 mitochondrion localization(GO:0051646)
0.1 0.8 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 0.6 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 0.5 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 2.0 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.3 GO:0042843 D-xylose catabolic process(GO:0042843)
0.1 0.3 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.1 1.0 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.3 GO:1901976 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.1 0.8 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.3 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 0.3 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 1.4 GO:0030242 pexophagy(GO:0030242)
0.1 0.3 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.1 0.3 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.1 0.8 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.1 0.2 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.1 0.7 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.4 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.2 GO:0006546 glycine catabolic process(GO:0006546)
0.1 1.3 GO:0012501 apoptotic process(GO:0006915) cell death(GO:0008219) programmed cell death(GO:0012501)
0.1 0.1 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.1 1.3 GO:0015918 sterol transport(GO:0015918)
0.1 0.3 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 1.3 GO:0031503 protein complex localization(GO:0031503)
0.1 0.6 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.5 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.6 GO:0016574 histone ubiquitination(GO:0016574)
0.1 1.1 GO:0016237 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.1 0.2 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 0.5 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 1.0 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.2 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.3 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.0 GO:0001324 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324) age-dependent general metabolic decline(GO:0007571)
0.0 0.5 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 0.3 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.0 0.2 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.1 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.0 0.2 GO:0045033 peroxisome inheritance(GO:0045033)
0.0 0.3 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.1 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.0 0.1 GO:0009107 lipoate metabolic process(GO:0009106) lipoate biosynthetic process(GO:0009107)
0.0 0.3 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.2 GO:0031297 replication fork processing(GO:0031297)
0.0 0.2 GO:0046174 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563) polyol catabolic process(GO:0046174)
0.0 0.2 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.0 0.3 GO:0051653 establishment of spindle localization(GO:0051293) spindle localization(GO:0051653)
0.0 0.1 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.0 1.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.2 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.0 0.1 GO:0043270 positive regulation of ion transport(GO:0043270)
0.0 0.5 GO:0048278 vesicle docking(GO:0048278)
0.0 0.4 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.1 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) UDP-glucose transport(GO:0015786)
0.0 0.6 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.8 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.9 GO:0022900 electron transport chain(GO:0022900)
0.0 0.2 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990)
0.0 0.1 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.7 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.3 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.1 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.0 0.2 GO:0009187 cyclic nucleotide metabolic process(GO:0009187)
0.0 0.1 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.0 0.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 1.1 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.1 GO:0001881 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.1 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.2 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.8 GO:0006839 mitochondrial transport(GO:0006839)
0.0 0.2 GO:0051181 cofactor transport(GO:0051181)
0.0 0.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.0 GO:2000045 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) regulation of cell cycle G1/S phase transition(GO:1902806) negative regulation of cell cycle G1/S phase transition(GO:1902807) positive regulation of cell cycle G1/S phase transition(GO:1902808) regulation of G1/S transition of mitotic cell cycle(GO:2000045) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.7 GO:0072666 protein targeting to vacuole(GO:0006623) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0 0.2 GO:0034401 chromatin organization involved in regulation of transcription(GO:0034401)
0.0 0.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.1 GO:0019400 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.0 0.2 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.2 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.9 GO:0006457 protein folding(GO:0006457)
0.0 0.0 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.1 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 13.5 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
1.3 15.7 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.1 8.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.9 2.7 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.8 2.3 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.7 2.1 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.7 3.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.6 1.9 GO:0032585 multivesicular body membrane(GO:0032585)
0.6 3.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.6 2.5 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.6 1.8 GO:0070211 Snt2C complex(GO:0070211)
0.6 2.8 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.5 1.5 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.5 2.8 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.4 1.3 GO:0030061 mitochondrial crista(GO:0030061)
0.4 2.9 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.4 1.1 GO:0032389 MutLalpha complex(GO:0032389)
0.4 1.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 1.7 GO:0001400 mating projection base(GO:0001400)
0.3 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 1.5 GO:0034448 EGO complex(GO:0034448)
0.3 4.8 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.2 0.9 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.2 1.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 5.1 GO:0098573 integral component of mitochondrial membrane(GO:0032592) intrinsic component of mitochondrial membrane(GO:0098573)
0.2 1.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.2 4.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 1.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.2 3.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 0.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 6.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.8 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 0.9 GO:0034657 GID complex(GO:0034657)
0.1 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.3 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.1 1.8 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 1.5 GO:0031902 late endosome membrane(GO:0031902)
0.1 3.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 0.3 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 2.2 GO:0016592 mediator complex(GO:0016592)
0.1 0.6 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.9 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.3 GO:0032126 eisosome(GO:0032126)
0.1 0.2 GO:0032176 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.1 9.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.8 GO:0097346 Swr1 complex(GO:0000812) INO80-type complex(GO:0097346)
0.1 0.2 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 0.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 4.7 GO:0019867 outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.1 0.6 GO:1902555 ribonuclease P complex(GO:0030677) endoribonuclease complex(GO:1902555)
0.1 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 2.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0035649 Nrd1 complex(GO:0035649)
0.0 0.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 15.2 GO:0005886 plasma membrane(GO:0005886)
0.0 0.3 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.9 GO:0005934 cellular bud tip(GO:0005934)
0.0 0.2 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.5 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0005769 early endosome(GO:0005769)
0.0 0.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.3 GO:0033698 Rpd3L complex(GO:0033698)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 9.3 GO:0005739 mitochondrion(GO:0005739)
0.0 0.0 GO:0031310 intrinsic component of vacuolar membrane(GO:0031310) vacuolar transporter chaperone complex(GO:0033254)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0008023 transcription elongation factor complex(GO:0008023)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.7 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
1.7 5.2 GO:0016289 CoA hydrolase activity(GO:0016289)
1.7 5.2 GO:0016208 AMP binding(GO:0016208)
1.5 5.9 GO:0005537 mannose binding(GO:0005537)
1.3 5.2 GO:0005471 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
1.2 13.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.1 5.7 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
1.1 7.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.9 2.8 GO:0048038 quinone binding(GO:0048038)
0.9 7.0 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.9 4.3 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.9 6.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.8 15.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.8 3.3 GO:0004396 hexokinase activity(GO:0004396)
0.8 2.5 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.8 1.6 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.8 3.1 GO:0016898 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.8 3.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.7 2.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.7 2.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.7 3.4 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.7 3.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.6 1.9 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.6 4.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.6 5.4 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.6 2.4 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.6 1.2 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.6 3.5 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.5 13.1 GO:0016836 hydro-lyase activity(GO:0016836)
0.5 1.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.5 1.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.5 5.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5 7.3 GO:0015293 symporter activity(GO:0015293)
0.5 1.8 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.4 4.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.4 1.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 1.1 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.4 2.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.3 1.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.3 4.2 GO:0022838 substrate-specific channel activity(GO:0022838)
0.3 0.3 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.3 0.3 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.3 2.7 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.3 1.2 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.3 1.4 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.3 1.4 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.3 2.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.3 3.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.3 0.3 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.2 2.0 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.2 1.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.2 1.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 0.7 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.2 1.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 2.0 GO:0008374 O-acyltransferase activity(GO:0008374)
0.2 3.1 GO:0008236 serine-type peptidase activity(GO:0008236)
0.2 0.8 GO:0016531 copper chaperone activity(GO:0016531)
0.2 0.6 GO:0015186 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.2 0.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 0.8 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.2 0.6 GO:0031406 amino acid binding(GO:0016597) carboxylic acid binding(GO:0031406) organic acid binding(GO:0043177)
0.2 0.9 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.2 4.5 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.2 2.4 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.2 1.5 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 0.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 1.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 0.6 GO:0008169 C-methyltransferase activity(GO:0008169)
0.2 2.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 0.6 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 2.5 GO:0016298 lipase activity(GO:0016298)
0.1 0.6 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 2.7 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 7.2 GO:0043492 ATPase activity, coupled to movement of substances(GO:0043492)
0.1 0.4 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 2.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 10.5 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 0.1 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 0.5 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.1 0.4 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 0.5 GO:1901618 alcohol transmembrane transporter activity(GO:0015665) organic hydroxy compound transmembrane transporter activity(GO:1901618)
0.1 0.5 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 0.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.7 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.1 GO:0015297 antiporter activity(GO:0015297)
0.1 1.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.4 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 1.8 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.5 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 0.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 2.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.3 GO:0001025 transcription factor activity, core RNA polymerase III binding(GO:0000995) RNA polymerase III transcription factor binding(GO:0001025) TFIIIB-type transcription factor activity(GO:0001026) TFIIIC-class transcription factor binding(GO:0001156)
0.1 0.3 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 0.5 GO:0008198 ferrous iron binding(GO:0008198)
0.1 1.0 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.1 0.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.5 GO:0000146 microfilament motor activity(GO:0000146)
0.1 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.4 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.1 0.2 GO:0051864 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) histone demethylase activity(GO:0032452) histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.5 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.1 0.2 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.1 0.2 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.4 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 0.5 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 0.9 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 0.3 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.1 0.7 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.1 0.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.6 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 2.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 1.1 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.1 0.7 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0015405 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405)
0.0 0.5 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.2 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.6 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.1 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.1 GO:0019003 GDP binding(GO:0019003)
0.0 0.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.2 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.2 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.7 2.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.6 1.7 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.4 1.1 PID NOTCH PATHWAY Notch signaling pathway
0.2 0.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 1.5 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 0.8 PID P73PATHWAY p73 transcription factor network
0.1 0.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 87.4 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.1 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 17.5 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.8 2.3 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.4 1.5 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.3 1.0 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.2 2.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 0.4 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 0.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 0.7 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 0.8 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1 87.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME INNATE IMMUNE SYSTEM Genes involved in Innate Immune System