Results for SUM1
Z-value: 4.01
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Transcription factors associated with SUM1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SUM1
|
S000002718 | Transcriptional repressor that regulates middle-sporulation genes |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YLR307C-A Show fit | 62.68 |
Putative protein of unknown function |
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| YAL062W Show fit | 46.80 |
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources |
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| YCR005C Show fit | 43.23 |
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors |
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| YDL210W Show fit | 26.24 |
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane |
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| YJL037W Show fit | 24.34 |
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci |
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| YJL133C-A Show fit | 23.82 |
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
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| YGR256W Show fit | 23.02 |
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone |
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| YPL240C Show fit | 22.50 |
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p |
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| YKL177W Show fit | 20.88 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3 |
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| YAR035W Show fit | 20.01 |
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated |
Network of associatons between targets according to the STRING database.
First level regulatory network of SUM1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 101.8 | GO:0071940 | ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940) |
| 6.8 | 61.4 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 8.1 | 48.5 | GO:0000501 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 15.0 | 45.1 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 1.7 | 40.0 | GO:0015749 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 11.4 | 34.1 | GO:0006577 | amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437) |
| 0.7 | 32.3 | GO:0034293 | sexual sporulation(GO:0034293) sexual sporulation resulting in formation of a cellular spore(GO:0043935) |
| 4.0 | 31.7 | GO:0045740 | positive regulation of DNA replication(GO:0045740) |
| 7.7 | 30.9 | GO:0015847 | putrescine transport(GO:0015847) |
| 3.0 | 30.4 | GO:0006098 | pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 85.5 | GO:0005886 | plasma membrane(GO:0005886) |
| 1.2 | 56.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 2.0 | 48.1 | GO:0042763 | prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764) |
| 3.7 | 44.0 | GO:0031160 | spore wall(GO:0031160) |
| 0.6 | 32.3 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 3.3 | 29.6 | GO:0045277 | mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) |
| 0.3 | 29.1 | GO:0000329 | fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852) |
| 2.3 | 27.4 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 1.1 | 27.3 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.5 | 22.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.1 | 48.5 | GO:0005537 | mannose binding(GO:0005537) |
| 11.3 | 45.1 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 14.4 | 43.2 | GO:0004108 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 6.2 | 37.0 | GO:0005354 | galactose transmembrane transporter activity(GO:0005354) |
| 11.4 | 34.1 | GO:0004092 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 10.5 | 31.5 | GO:0015489 | putrescine transmembrane transporter activity(GO:0015489) |
| 3.0 | 29.6 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 4.3 | 26.0 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 4.1 | 24.9 | GO:0016744 | transferase activity, transferring aldehyde or ketonic groups(GO:0016744) |
| 1.8 | 19.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 581.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 4.9 | 14.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 2.4 | 7.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 2.0 | 6.1 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 1.2 | 2.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.3 | 1.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.9 | 1.8 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.9 | 0.9 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.2 | 0.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 0.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 567.2 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 4.9 | 14.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 2.3 | 7.0 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.4 | 3.9 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.4 | 3.4 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.9 | 2.8 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.4 | 1.8 | REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | Genes involved in NGF signalling via TRKA from the plasma membrane |
| 0.4 | 1.7 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 1.4 | 1.4 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 0.9 | 0.9 | REACTOME PI3K EVENTS IN ERBB2 SIGNALING | Genes involved in PI3K events in ERBB2 signaling |