Navigation
Downloads

Results for SWI4

Z-value: 1.97

Motif logo

logo of

Transcription factors associated with SWI4

Gene Symbol Gene ID Gene Info
SWI4
S000000913 DNA binding component of the SBF complex (Swi4p-Swi6p)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SWI4YER111C-0.048.6e-01Click!

Activity profile of SWI4 motif

Sorted Z-values of SWI4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YNL301C 27.37
RPL18B
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YPL256C 24.89
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YKL096W-A 22.75
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YNL289W 21.43
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YJR094W-A 18.31
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YGL179C 18.29
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YGR108W 17.74
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YNL300W 17.43 Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YER070W 17.34
RNR1
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YDL055C 15.13
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YDL211C 14.82 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YPR119W 13.78
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YIL118W 12.99
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YDR044W 12.59
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YJL158C 12.54
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YMR199W 12.19
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YLR325C 11.40
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YOL007C 11.15
CSI2
Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
YKR013W 10.49
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YFR055W 10.40
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YOR226C 10.33
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YPL163C 10.31
SVS1
Cell wall and vacuolar protein, required for wild-type resistance to vanadate
YGL147C 10.09
RPL9A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YPL250W-A 9.82 Identified by fungal homology and RT-PCR
YLR185W 9.37
RPL37A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YEL040W 9.32
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YLR183C 9.22
TOS4
Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YFR056C 9.22 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YCR018C 9.08
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YNL030W 9.04
HHF2
One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YIR021W 9.03
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YLR441C 8.87
RPS1A
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
YOL101C 8.86
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YGR152C 8.85
RSR1
GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
YER001W 8.80
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YKR012C 8.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YMR049C 8.65
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YIL169C 8.57 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YGL031C 8.45
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YPL255W 8.41
BBP1
Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YGL201C 8.32
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YGL225W 8.00
VRG4
Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YDL227C 7.93
HO
Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
YDR224C 7.90
HTB1
One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YOL015W 7.89
IRC10
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YOL039W 7.89
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YOR342C 7.72 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YFL045C 7.33
SEC53
Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
YOL040C 7.30
RPS15
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YMR307W 7.27
GAS1
Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
YBR009C 7.19
HHF1
One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YBR143C 7.19
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YIL069C 7.19
RPS24B
Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YHR141C 7.15
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YEL001C 7.13
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YFL015W-A 7.12 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR305C 7.09
SCW10
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YGL030W 7.09
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YBR210W 6.93
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YOR376W-A 6.88 Putative protein of unknown function; identified by fungal homology and RT-PCR
YDL191W 6.83
RPL35A
Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YFL015C 6.81 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YLR110C 6.71
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YBR088C 6.68
POL30
Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
YEL068C 6.62 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR034W 6.61
FEN1
Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YEL053W-A 6.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YDR382W 6.50
RPP2B
Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YDL003W 6.30
MCD1
Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase
YER003C 6.16
PMI40
Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YJL080C 6.12
SCP160
Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
YNL178W 6.12
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YDR002W 6.11
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YLR314C 6.07
CDC3
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YAL033W 6.06
POP5
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YDR309C 6.03
GIC2
Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YCL063W 6.03
VAC17
Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YDR225W 5.99
HTA1
One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YDR509W 5.85 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR375C 5.69
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YDR508C 5.63
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YJL115W 5.62
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YDR399W 5.54
HPT1
Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YOL016C 5.48
CMK2
Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II
YDL192W 5.45
ARF1
ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
YCL024W 5.43
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YKL122C 5.37
SRP21
Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YDL228C 5.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1
YHR094C 5.35
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YDL145C 5.32
COP1
Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
YLR388W 5.26
RPS29A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YKL110C 5.26
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YHR216W 5.25
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YKR092C 5.23
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YNL231C 5.19
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YDR098C 5.14
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YGL178W 5.13
MPT5
Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
YGR189C 5.12
CRH1
Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions
YIL133C 5.12
RPL16A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YDR381W 5.10
YRA1
Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
YCR065W 5.09
HCM1
Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role
YHR123W 5.08
EPT1
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability
YGR214W 5.07
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YER118C 4.89
SHO1
Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway
YMR083W 4.88
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YMR144W 4.86 Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YNL111C 4.85
CYB5
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YMR108W 4.85
ILV2
Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YDL014W 4.79
NOP1
Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YBR010W 4.75
HHT1
One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YLR180W 4.72
SAM1
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YNL031C 4.72
HHT2
One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YGR138C 4.72
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YEL066W 4.72
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YGR187C 4.69
HGH1
Nonessential protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)
YDL219W 4.68
DTD1
D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
YBR112C 4.68
CYC8
General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YGR090W 4.66
UTP22
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YKL063C 4.62 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YCL023C 4.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YGL039W 4.56 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YER137C 4.51 Putative protein of unknown function
YGR140W 4.47
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YKL068W-A 4.45 Putative protein of unknown function; identified by homology to Ashbya gossypii
YER156C 4.44 Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YKR038C 4.43
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YKL218C 4.42
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YLR061W 4.41
RPL22A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein
YIL123W 4.38
SIM1
Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YJR043C 4.37
POL32
Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YGL123C-A 4.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YGL123W 4.33
RPS2
Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YBL009W 4.24
ALK2
Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins
YDR500C 4.22
RPL37B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
YGR229C 4.15
SMI1
Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YGR148C 4.14
RPL24B
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YMR296C 4.10
LCB1
Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YPL263C 4.10
KEL3
Cytoplasmic protein of unknown function
YDR064W 4.09
RPS13
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins
YDL189W 4.08
RBS1
Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
YBR244W 4.07
GPX2
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YPL227C 3.97
ALG5
UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
YLR406C 3.95
RPL31B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YBL085W 3.93
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YCL058C 3.92
FYV5
Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
YKL165C 3.89
MCD4
Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YJL200C 3.85
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YBL031W 3.84
SHE1
Cytoskeletal protein of unknown function; overexpression causes growth arrest
YHL015W 3.84
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YCL064C 3.83
CHA1
Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YEL067C 3.83 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL101W 3.81
HSL1
Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YLR339C 3.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
YFL037W 3.78
TUB2
Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules
YBR113W 3.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YLR084C 3.76
RAX2
N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p
YOR247W 3.76
SRL1
Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YKL042W 3.72
SPC42
Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
YHR149C 3.70
SKG6
Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YLR372W 3.69
SUR4
Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YGR040W 3.67
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YJR123W 3.67
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YHR007C 3.66
ERG11
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YPR157W 3.66 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YIL009W 3.64
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YPL267W 3.62
ACM1
Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins
YNL016W 3.62
PUB1
Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
YLR340W 3.62
RPP0
Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302
YFL022C 3.58
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YKL128C 3.56
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YBR106W 3.54
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YDR072C 3.54
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YOL005C 3.52
RPB11
RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YNR053C 3.50
NOG2
Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YOR309C 3.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
YLR137W 3.48 Putative protein of unknown function
YBR232C 3.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL212W 3.48
SAC1
Phosphatidylinositol (PI) phosphatase, involved in hydrolysis of PI 3-phosphate, PI 4-phosphate and PI 3,5-bisphosphate to PI; membrane protein localizes to ER and Golgi; involved in protein trafficking, secretion and inositol metabolism
YOR198C 3.46
BFR1
Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity
YGR106C 3.46
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YLR042C 3.45 Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YBR233W 3.43
PBP2
RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length
YJL035C 3.41
TAD2
Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
YOL113W 3.40
SKM1
Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; proposed to be a downstream effector of Cdc42p during polarized growth
YMR121C 3.36
RPL15B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YIR033W 3.36
MGA2
ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YNL066W 3.33
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YFL016C 3.32
MDJ1
Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YMR215W 3.30
GAS3
Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YGR139W 3.30 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL065W 3.30
AQR1
Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YIL056W 3.30
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YER146W 3.29
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YLR432W 3.28
IMD3
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YCR099C 3.26 Putative protein of unknown function
YPL124W 3.25
SPC29
Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication
YMR015C 3.25
ERG5
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YMR037C 3.22
MSN2
Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YDR345C 3.22
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YHR172W 3.17
SPC97
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque

Network of associatons between targets according to the STRING database.

First level regulatory network of SWI4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.5 28.6 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
4.6 32.1 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
3.6 3.6 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
3.5 17.4 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
3.5 10.4 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
3.3 13.3 GO:0017157 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
3.1 9.3 GO:0046416 D-amino acid metabolic process(GO:0046416)
3.0 11.8 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
2.9 14.7 GO:0006177 GMP biosynthetic process(GO:0006177)
2.9 26.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
2.7 10.9 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
2.6 10.3 GO:0030497 fatty acid elongation(GO:0030497)
2.5 5.0 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
2.5 7.4 GO:0035953 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
2.3 16.2 GO:0034729 histone H3-K79 methylation(GO:0034729)
2.3 15.9 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
2.2 6.6 GO:0006567 threonine catabolic process(GO:0006567)
2.2 6.5 GO:0043484 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
2.0 10.0 GO:0015780 nucleotide-sugar transport(GO:0015780)
2.0 35.8 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
2.0 5.9 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.9 3.8 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
1.8 3.7 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
1.8 1.8 GO:0032365 intracellular lipid transport(GO:0032365)
1.8 40.5 GO:0006334 nucleosome assembly(GO:0006334)
1.8 3.5 GO:0030541 plasmid partitioning(GO:0030541)
1.8 5.3 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
1.7 6.8 GO:0098609 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
1.7 10.0 GO:0007534 gene conversion at mating-type locus(GO:0007534)
1.7 19.8 GO:0007120 axial cellular bud site selection(GO:0007120)
1.6 4.9 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
1.6 4.8 GO:2001021 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
1.6 1.6 GO:0030261 chromosome condensation(GO:0030261)
1.5 4.6 GO:0061422 cellular response to zinc ion starvation(GO:0034224) regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation(GO:0034225) positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422) regulation of cell aging(GO:0090342) regulation of replicative cell aging(GO:1900062)
1.5 9.0 GO:0006491 N-glycan processing(GO:0006491)
1.5 205.1 GO:0002181 cytoplasmic translation(GO:0002181)
1.5 5.9 GO:0006657 CDP-choline pathway(GO:0006657)
1.4 7.2 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
1.4 2.9 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
1.3 5.4 GO:0000296 spermine transport(GO:0000296)
1.3 10.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.3 10.3 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
1.3 18.1 GO:0006037 cell wall chitin metabolic process(GO:0006037)
1.3 3.9 GO:0046677 response to antibiotic(GO:0046677)
1.3 3.8 GO:0070868 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
1.2 1.2 GO:0070475 rRNA base methylation(GO:0070475)
1.2 14.4 GO:0006272 leading strand elongation(GO:0006272)
1.2 7.2 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
1.2 3.6 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
1.2 4.7 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
1.2 3.5 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
1.1 6.8 GO:0030030 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
1.1 1.1 GO:0045901 positive regulation of translational elongation(GO:0045901)
1.1 3.3 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015)
1.1 2.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
1.1 2.1 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.9 23.6 GO:0006885 regulation of pH(GO:0006885)
0.9 4.5 GO:0009098 leucine biosynthetic process(GO:0009098)
0.9 4.4 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.9 2.6 GO:0043069 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.9 12.3 GO:0015918 sterol transport(GO:0015918)
0.9 4.4 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.9 1.8 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.9 8.8 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.9 2.6 GO:0045128 negative regulation of reciprocal meiotic recombination(GO:0045128)
0.9 14.0 GO:0030474 spindle pole body duplication(GO:0030474)
0.9 5.2 GO:0009099 valine biosynthetic process(GO:0009099)
0.8 1.7 GO:0032006 regulation of TOR signaling(GO:0032006)
0.8 0.8 GO:0000090 mitotic anaphase(GO:0000090)
0.8 10.1 GO:0034963 box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963)
0.8 7.6 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.8 1.5 GO:0071482 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.8 10.7 GO:0006415 translational termination(GO:0006415)
0.8 3.0 GO:1900434 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.8 1.5 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.7 3.0 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.7 9.7 GO:0030011 maintenance of cell polarity(GO:0030011)
0.7 5.1 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.7 10.1 GO:0000011 vacuole inheritance(GO:0000011)
0.7 23.6 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.7 2.1 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.7 6.4 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.7 2.1 GO:0048313 Golgi inheritance(GO:0048313)
0.7 14.4 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.7 2.7 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.7 2.7 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.7 5.4 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.7 2.7 GO:0000032 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.6 1.9 GO:0043171 peptide catabolic process(GO:0043171)
0.6 1.9 GO:1902223 L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.6 0.6 GO:0032368 regulation of lipid transport(GO:0032368)
0.6 8.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.6 2.5 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.6 4.4 GO:0034063 stress granule assembly(GO:0034063)
0.6 14.9 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.6 3.7 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.6 2.4 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.6 0.6 GO:1902931 negative regulation of alcohol biosynthetic process(GO:1902931)
0.6 12.8 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.6 17.3 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.6 2.3 GO:0046417 chorismate metabolic process(GO:0046417)
0.5 1.1 GO:0071044 histone mRNA metabolic process(GO:0008334) histone mRNA catabolic process(GO:0071044)
0.5 1.6 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.5 1.1 GO:1901351 regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
0.5 2.7 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 2.2 GO:0006750 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.5 6.9 GO:0006284 base-excision repair(GO:0006284)
0.5 0.5 GO:0007050 cell cycle arrest(GO:0007050)
0.5 4.2 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.5 6.8 GO:0030473 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.5 4.2 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.5 2.1 GO:0015867 ATP transport(GO:0015867)
0.5 2.5 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.5 1.5 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.5 0.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.5 0.5 GO:0010383 cell wall polysaccharide metabolic process(GO:0010383)
0.5 1.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.5 0.9 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.5 1.9 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.5 4.1 GO:0032508 DNA duplex unwinding(GO:0032508)
0.5 4.6 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.5 1.8 GO:0042357 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.4 4.0 GO:0007118 budding cell apical bud growth(GO:0007118)
0.4 6.1 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.4 0.4 GO:0007535 donor selection(GO:0007535)
0.4 1.3 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.4 6.2 GO:0030488 tRNA methylation(GO:0030488)
0.4 3.7 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.4 1.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.4 1.2 GO:0000916 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.4 0.8 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.4 1.6 GO:0030835 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.4 1.6 GO:0043007 maintenance of rDNA(GO:0043007)
0.4 0.8 GO:0046999 regulation of conjugation with cellular fusion(GO:0031137) regulation of conjugation(GO:0046999)
0.4 1.9 GO:0070813 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.4 9.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.4 14.4 GO:0043087 regulation of GTPase activity(GO:0043087)
0.4 1.1 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.4 2.6 GO:0006814 sodium ion transport(GO:0006814)
0.4 4.1 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.4 0.7 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.4 1.8 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.3 2.8 GO:0015677 copper ion import(GO:0015677)
0.3 3.5 GO:0006526 arginine biosynthetic process(GO:0006526)
0.3 0.7 GO:0007000 nucleolus organization(GO:0007000)
0.3 1.7 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.3 1.3 GO:0043102 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.3 1.9 GO:0071039 nuclear polyadenylation-dependent CUT catabolic process(GO:0071039)
0.3 7.7 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.3 0.9 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.3 2.2 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.3 5.1 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.3 2.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.3 6.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.3 0.6 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.3 0.9 GO:0034501 protein localization to kinetochore(GO:0034501)
0.3 12.3 GO:0008033 tRNA processing(GO:0008033)
0.3 1.7 GO:0016584 nucleosome positioning(GO:0016584)
0.3 3.9 GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0000750) signal transduction involved in conjugation with cellular fusion(GO:0032005)
0.3 1.1 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.3 1.4 GO:0071028 nuclear mRNA surveillance(GO:0071028)
0.3 1.4 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.3 1.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 1.4 GO:0007021 tubulin complex assembly(GO:0007021)
0.3 3.5 GO:0006999 nuclear pore organization(GO:0006999)
0.3 3.7 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.3 0.8 GO:0060988 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.3 1.8 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.3 1.0 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.3 4.3 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.2 1.5 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.2 3.2 GO:0046839 phospholipid dephosphorylation(GO:0046839) phosphatidylinositol dephosphorylation(GO:0046856)
0.2 0.5 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.2 4.9 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.2 1.0 GO:0001304 progressive alteration of chromatin involved in replicative cell aging(GO:0001304) negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.2 2.9 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.2 0.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 3.5 GO:0006734 NADH metabolic process(GO:0006734)
0.2 0.7 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.2 0.7 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.2 8.6 GO:0000747 conjugation with cellular fusion(GO:0000747)
0.2 4.0 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 0.9 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.2 1.3 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.2 0.7 GO:0036260 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260)
0.2 0.2 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.2 2.0 GO:0009303 rRNA transcription(GO:0009303)
0.2 6.1 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.2 0.4 GO:0045948 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402) positive regulation of translational initiation(GO:0045948)
0.2 1.9 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.2 1.0 GO:0030811 regulation of glycolytic process(GO:0006110) regulation of nucleoside metabolic process(GO:0009118) regulation of nucleotide catabolic process(GO:0030811) regulation of cofactor metabolic process(GO:0051193) regulation of coenzyme metabolic process(GO:0051196) regulation of ATP metabolic process(GO:1903578)
0.2 0.8 GO:0015883 FAD transport(GO:0015883)
0.2 0.8 GO:0018202 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202)
0.2 2.8 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.2 1.4 GO:0009306 protein secretion(GO:0009306)
0.2 7.8 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.2 6.3 GO:0006413 translational initiation(GO:0006413)
0.2 17.6 GO:0006364 rRNA processing(GO:0006364)
0.2 0.7 GO:0048255 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.2 0.7 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.2 0.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 1.4 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.2 1.1 GO:0007009 plasma membrane organization(GO:0007009)
0.2 0.2 GO:0006344 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.2 3.0 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.1 0.1 GO:2000242 negative regulation of reproductive process(GO:2000242)
0.1 1.5 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 4.0 GO:0043039 amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)
0.1 0.1 GO:0007052 mitotic spindle organization(GO:0007052)
0.1 0.8 GO:0032973 amino acid export(GO:0032973)
0.1 3.6 GO:0051302 regulation of cell division(GO:0051302)
0.1 1.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 1.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.4 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.1 6.1 GO:0006913 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.1 0.5 GO:0045116 protein neddylation(GO:0045116)
0.1 1.1 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
0.1 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.4 GO:0009636 response to toxic substance(GO:0009636)
0.1 1.7 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 0.2 GO:0042255 ribosome assembly(GO:0042255)
0.1 0.4 GO:0006026 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.1 0.2 GO:0090337 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.1 0.6 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 0.2 GO:0071072 negative regulation of lipid biosynthetic process(GO:0051055) negative regulation of phospholipid biosynthetic process(GO:0071072) negative regulation of phospholipid metabolic process(GO:1903726)
0.1 0.2 GO:0035066 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.1 0.2 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.3 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.1 0.4 GO:0006613 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.2 GO:0051260 protein homooligomerization(GO:0051260)
0.1 0.7 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.1 0.5 GO:0032120 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.7 GO:0097033 mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.5 GO:0016559 peroxisome fission(GO:0016559)
0.1 0.2 GO:0006448 regulation of translational elongation(GO:0006448)
0.1 0.8 GO:0042181 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.1 0.4 GO:0006862 nucleotide transport(GO:0006862)
0.1 0.1 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021)
0.1 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 0.2 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.1 1.5 GO:0009135 purine nucleoside diphosphate metabolic process(GO:0009135) purine ribonucleoside diphosphate metabolic process(GO:0009179) ribonucleoside diphosphate metabolic process(GO:0009185) ADP metabolic process(GO:0046031)
0.1 5.2 GO:0006468 protein phosphorylation(GO:0006468)
0.1 3.0 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.1 0.1 GO:0010978 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.1 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.3 GO:0009088 threonine biosynthetic process(GO:0009088)
0.0 0.3 GO:0007323 peptide pheromone maturation(GO:0007323)
0.0 1.0 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.7 GO:0009100 glycoprotein metabolic process(GO:0009100) glycoprotein biosynthetic process(GO:0009101)
0.0 0.2 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.0 0.1 GO:0001109 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.0 0.1 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.0 0.4 GO:0009267 cellular response to starvation(GO:0009267)
0.0 0.2 GO:0048278 vesicle docking(GO:0048278)
0.0 0.2 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.0 0.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.1 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.1 GO:0006563 L-serine metabolic process(GO:0006563)
0.0 0.1 GO:0015758 glucose transport(GO:0015758)
0.0 0.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.0 0.2 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 42.9 GO:0000788 nuclear nucleosome(GO:0000788)
3.6 60.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
2.9 8.7 GO:0070545 PeBoW complex(GO:0070545)
2.8 13.8 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
2.7 2.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
2.1 179.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
2.0 7.9 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
1.9 7.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
1.9 9.5 GO:0000408 EKC/KEOPS complex(GO:0000408)
1.8 11.0 GO:0042555 MCM complex(GO:0042555)
1.8 5.5 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
1.8 5.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.8 7.1 GO:0017053 transcriptional repressor complex(GO:0017053)
1.8 15.8 GO:0000144 cellular bud neck septin ring(GO:0000144)
1.7 5.0 GO:0044697 HICS complex(GO:0044697)
1.6 1.6 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
1.5 9.0 GO:0005940 septin ring(GO:0005940)
1.5 5.9 GO:0005880 nuclear microtubule(GO:0005880)
1.4 8.5 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
1.3 6.6 GO:0032545 CURI complex(GO:0032545)
1.3 6.4 GO:0005823 central plaque of spindle pole body(GO:0005823)
1.2 2.5 GO:0000786 nucleosome(GO:0000786)
1.2 74.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.2 7.2 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
1.2 8.2 GO:0000346 transcription export complex(GO:0000346)
1.1 3.2 GO:0000930 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) inner plaque of spindle pole body(GO:0005822) gamma-tubulin small complex(GO:0008275)
1.1 8.4 GO:0030126 COPI vesicle coat(GO:0030126)
1.0 4.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
1.0 4.0 GO:0000811 GINS complex(GO:0000811)
1.0 6.9 GO:0051233 spindle midzone(GO:0051233)
0.9 6.1 GO:0043614 multi-eIF complex(GO:0043614)
0.9 3.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.9 4.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.8 0.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.8 2.5 GO:0032301 MutSalpha complex(GO:0032301)
0.8 3.4 GO:0005871 kinesin complex(GO:0005871)
0.8 62.1 GO:0005576 extracellular region(GO:0005576)
0.8 4.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.8 3.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.7 4.4 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.7 1.4 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.7 2.9 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.7 2.7 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.7 2.0 GO:0005845 mRNA cap binding complex(GO:0005845)
0.7 2.7 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.7 2.0 GO:0030874 nucleolar chromatin(GO:0030874)
0.7 2.0 GO:0033186 CAF-1 complex(GO:0033186)
0.7 2.6 GO:0044611 nuclear pore inner ring(GO:0044611)
0.6 2.5 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.6 22.1 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.6 3.7 GO:0042597 periplasmic space(GO:0042597)
0.6 18.1 GO:0005844 polysome(GO:0005844)
0.6 0.6 GO:0034455 t-UTP complex(GO:0034455)
0.6 4.5 GO:0005688 U6 snRNP(GO:0005688)
0.6 1.7 GO:0097344 Rix1 complex(GO:0097344)
0.6 2.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.6 1.1 GO:0005796 Golgi lumen(GO:0005796)
0.5 2.1 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.5 4.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.5 4.7 GO:0033553 rDNA heterochromatin(GO:0033553)
0.5 1.5 GO:0031415 NatA complex(GO:0031415)
0.5 1.5 GO:0000417 HIR complex(GO:0000417)
0.5 6.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.5 2.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.5 3.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.5 2.9 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.5 2.4 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.4 1.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.4 1.8 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.4 1.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 3.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.4 1.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.4 1.7 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.4 5.3 GO:0022626 cytosolic ribosome(GO:0022626)
0.4 1.6 GO:0097196 Shu complex(GO:0097196)
0.4 0.8 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.4 7.3 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.4 1.2 GO:0034457 Mpp10 complex(GO:0034457)
0.4 3.5 GO:0000137 Golgi cis cisterna(GO:0000137)
0.4 3.5 GO:0042729 DASH complex(GO:0042729)
0.4 3.5 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.4 1.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.4 2.3 GO:0000133 polarisome(GO:0000133)
0.4 1.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.4 2.9 GO:0000792 heterochromatin(GO:0000792)
0.4 43.6 GO:0005935 cellular bud neck(GO:0005935)
0.4 1.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.4 8.2 GO:0009277 fungal-type cell wall(GO:0009277)
0.4 1.8 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 1.1 GO:0000262 cytoplasmic chromosome(GO:0000229) mitochondrial chromosome(GO:0000262)
0.3 3.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 0.6 GO:0030869 RENT complex(GO:0030869)
0.3 2.2 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.3 0.6 GO:0008278 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.3 2.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541) endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.3 2.3 GO:0005876 spindle microtubule(GO:0005876)
0.3 1.1 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.3 2.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.3 0.8 GO:0030689 Noc complex(GO:0030689)
0.3 2.2 GO:0030008 TRAPP complex(GO:0030008)
0.3 4.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 1.4 GO:0016272 prefoldin complex(GO:0016272)
0.3 1.8 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.3 4.5 GO:0016586 RSC complex(GO:0016586)
0.2 0.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 0.7 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.2 4.8 GO:0005657 replication fork(GO:0005657)
0.2 3.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 0.2 GO:0031391 Elg1 RFC-like complex(GO:0031391)
0.2 0.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 5.3 GO:0012506 vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659)
0.2 1.9 GO:0000243 commitment complex(GO:0000243)
0.2 0.8 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.2 2.6 GO:0032040 small-subunit processome(GO:0032040)
0.2 7.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 3.6 GO:0070847 core mediator complex(GO:0070847)
0.2 0.7 GO:0000817 COMA complex(GO:0000817)
0.2 5.7 GO:0005811 lipid particle(GO:0005811)
0.2 1.0 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 0.7 GO:0000938 GARP complex(GO:0000938)
0.2 1.2 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 5.3 GO:0005933 cellular bud(GO:0005933)
0.1 0.1 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.1 0.4 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.1 0.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 25.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 7.2 GO:0000139 Golgi membrane(GO:0000139)
0.1 2.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 17.2 GO:0005730 nucleolus(GO:0005730)
0.1 0.8 GO:0000974 Prp19 complex(GO:0000974)
0.1 1.1 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.5 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.1 4.3 GO:0005643 nuclear pore(GO:0005643)
0.1 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.4 GO:0030907 MBF transcription complex(GO:0030907)
0.1 0.3 GO:0032116 SMC loading complex(GO:0032116)
0.1 0.9 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 0.8 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 12.4 GO:0005829 cytosol(GO:0005829)
0.1 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.3 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.9 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.1 0.1 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.7 GO:0036452 ESCRT complex(GO:0036452)
0.0 0.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.5 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.1 GO:0070823 HDA1 complex(GO:0070823)
0.0 0.5 GO:0098589 membrane region(GO:0098589)
0.0 2.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.1 GO:0030897 HOPS complex(GO:0030897)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0070209 ASTRA complex(GO:0070209)
0.0 0.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.1 GO:0070568 guanylyltransferase activity(GO:0070568)
3.4 10.3 GO:0009922 fatty acid elongase activity(GO:0009922)
3.4 88.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
3.2 38.2 GO:0005199 structural constituent of cell wall(GO:0005199)
3.2 12.7 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
2.8 8.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
2.8 11.1 GO:0016841 ammonia-lyase activity(GO:0016841)
2.6 10.5 GO:0009378 four-way junction helicase activity(GO:0009378)
2.2 6.5 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
2.1 8.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
2.0 10.0 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
1.8 5.5 GO:0072341 modified amino acid binding(GO:0072341)
1.8 5.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.8 10.8 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
1.8 8.8 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.7 6.9 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
1.7 6.7 GO:0005034 osmosensor activity(GO:0005034)
1.5 1.5 GO:0015248 sterol transporter activity(GO:0015248)
1.5 47.7 GO:0046982 protein heterodimerization activity(GO:0046982)
1.5 5.9 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.4 8.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.4 7.1 GO:0036002 pre-mRNA binding(GO:0036002)
1.4 2.7 GO:0019104 DNA N-glycosylase activity(GO:0019104)
1.3 5.4 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
1.3 5.3 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
1.3 7.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
1.3 7.8 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
1.3 12.7 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
1.3 3.8 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
1.3 6.3 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
1.3 2.5 GO:0000403 Y-form DNA binding(GO:0000403)
1.2 3.7 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.2 3.7 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
1.2 4.9 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
1.2 6.1 GO:0008536 Ran GTPase binding(GO:0008536)
1.2 7.2 GO:0016408 C-acyltransferase activity(GO:0016408)
1.2 3.6 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
1.2 5.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.2 5.9 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
1.1 3.4 GO:0051010 microtubule plus-end binding(GO:0051010)
1.1 3.4 GO:0008251 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
1.1 219.0 GO:0003735 structural constituent of ribosome(GO:0003735)
1.1 13.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
1.0 5.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.0 3.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.0 4.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.0 3.9 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.9 2.8 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.9 4.6 GO:0017048 Rho GTPase binding(GO:0017048)
0.9 5.4 GO:0008312 7S RNA binding(GO:0008312)
0.9 1.8 GO:0004529 exodeoxyribonuclease activity(GO:0004529)
0.9 2.6 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.9 2.6 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.8 2.5 GO:0001187 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
0.8 2.5 GO:0043812 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.8 3.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.8 7.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.8 6.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.7 7.4 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.7 4.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.7 4.2 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.7 2.7 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.7 3.4 GO:0004707 MAP kinase activity(GO:0004707)
0.7 2.6 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.7 2.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.7 2.0 GO:0019003 GDP binding(GO:0019003)
0.6 5.7 GO:0001055 RNA polymerase II activity(GO:0001055)
0.6 42.0 GO:0003924 GTPase activity(GO:0003924)
0.6 4.9 GO:0019842 vitamin binding(GO:0019842)
0.6 2.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.6 1.8 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.6 2.9 GO:0003777 microtubule motor activity(GO:0003777)
0.6 1.7 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.6 6.7 GO:0005516 calmodulin binding(GO:0005516)
0.5 1.6 GO:0070569 uridylyltransferase activity(GO:0070569)
0.5 1.1 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.5 2.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.5 1.6 GO:0003680 AT DNA binding(GO:0003680)
0.5 2.1 GO:0004771 sterol esterase activity(GO:0004771)
0.5 4.2 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.5 2.1 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.5 2.0 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.5 4.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.5 9.2 GO:0030515 snoRNA binding(GO:0030515)
0.5 3.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.5 1.8 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.5 0.9 GO:0015645 fatty acid ligase activity(GO:0015645)
0.4 2.6 GO:0019237 centromeric DNA binding(GO:0019237)
0.4 3.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.4 1.7 GO:0008242 omega peptidase activity(GO:0008242)
0.4 2.5 GO:0003993 acid phosphatase activity(GO:0003993)
0.4 1.2 GO:0004100 chitin synthase activity(GO:0004100)
0.4 3.3 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.4 17.2 GO:0004519 endonuclease activity(GO:0004519)
0.4 1.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.4 14.9 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.4 2.7 GO:0016778 diphosphotransferase activity(GO:0016778)
0.4 1.2 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.4 1.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.4 4.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.4 1.4 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.4 1.8 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.4 0.4 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.3 5.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.3 1.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.3 0.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 10.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 1.0 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.3 0.9 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.3 11.8 GO:0042393 histone binding(GO:0042393)
0.3 0.9 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.3 1.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 2.7 GO:0043022 ribosome binding(GO:0043022)
0.3 10.3 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.3 1.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.3 8.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 2.2 GO:0000149 SNARE binding(GO:0000149)
0.3 2.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.3 2.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.3 0.5 GO:0030145 manganese ion binding(GO:0030145)
0.3 2.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.3 1.0 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.3 1.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.3 1.0 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 3.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 2.7 GO:0000182 rDNA binding(GO:0000182)
0.2 1.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 3.3 GO:0001671 ATPase activator activity(GO:0001671)
0.2 1.2 GO:0070403 NAD+ binding(GO:0070403)
0.2 0.7 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.2 2.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 2.5 GO:0000049 tRNA binding(GO:0000049)
0.2 1.3 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.2 0.7 GO:0000339 RNA cap binding(GO:0000339)
0.2 1.3 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 1.5 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.2 4.5 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.2 1.9 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 0.8 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.2 2.4 GO:0019904 protein domain specific binding(GO:0019904)
0.2 4.0 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.2 0.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.2 6.7 GO:0043130 ubiquitin binding(GO:0043130)
0.2 0.8 GO:0001167 RNA polymerase I transcription factor activity, sequence-specific DNA binding(GO:0001167)
0.2 0.5 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.2 0.5 GO:0000146 microfilament motor activity(GO:0000146)
0.2 2.0 GO:0043495 protein anchor(GO:0043495)
0.2 0.7 GO:0004017 adenylate kinase activity(GO:0004017)
0.2 4.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.2 2.3 GO:0016866 intramolecular transferase activity(GO:0016866)
0.2 0.7 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.2 1.2 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.2 0.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 1.0 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 4.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 0.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.2 1.1 GO:0003724 RNA helicase activity(GO:0003724)
0.2 0.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 3.9 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.2 0.3 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 7.3 GO:0030695 GTPase regulator activity(GO:0030695)
0.2 29.3 GO:0003723 RNA binding(GO:0003723)
0.1 0.7 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.1 14.1 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 0.3 GO:0019202 amino acid kinase activity(GO:0019202)
0.1 1.0 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 1.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.1 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.1 0.9 GO:0031386 protein tag(GO:0031386)
0.1 1.2 GO:0015616 DNA translocase activity(GO:0015616)
0.1 1.0 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.2 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 0.2 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.7 GO:0051087 chaperone binding(GO:0051087)
0.1 0.3 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.1 0.9 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 1.0 GO:0051015 actin filament binding(GO:0051015)
0.1 0.5 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.4 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 5.2 GO:0003682 chromatin binding(GO:0003682)
0.1 0.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 1.0 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 0.8 GO:0005048 signal sequence binding(GO:0005048)
0.1 0.6 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.1 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.1 0.2 GO:0051213 dioxygenase activity(GO:0051213)
0.1 0.3 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 0.4 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 2.0 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.0 2.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.1 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.2 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.5 GO:0019001 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0042277 peptide binding(GO:0042277)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0019207 kinase regulator activity(GO:0019207)
0.0 0.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.5 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.8 GO:0051082 unfolded protein binding(GO:0051082)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.1 3.2 PID SHP2 PATHWAY SHP2 signaling
0.8 2.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.7 1.4 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.7 0.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.5 1.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.4 1.2 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.4 1.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 2.4 PID ATR PATHWAY ATR signaling pathway
0.2 0.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 0.7 PID P73PATHWAY p73 transcription factor network
0.1 0.3 PID FGF PATHWAY FGF signaling pathway
0.1 0.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 0.5 PID PLK1 PATHWAY PLK1 signaling events
0.1 0.4 PID E2F PATHWAY E2F transcription factor network
0.1 0.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.0 NABA MATRISOME Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins
0.0 0.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 29.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
2.4 38.8 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
1.8 5.5 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
1.6 11.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.6 6.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
1.3 4.0 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
1.3 3.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
1.3 3.8 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.9 2.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.9 5.2 REACTOME DNA STRAND ELONGATION Genes involved in DNA strand elongation
0.7 1.4 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.5 1.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.4 3.5 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.4 1.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 1.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 1.9 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 1.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 0.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.3 REACTOME CELL CYCLE CHECKPOINTS Genes involved in Cell Cycle Checkpoints
0.1 0.5 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.1 0.7 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.1 0.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION Genes involved in Post-translational protein modification