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Results for THI2

Z-value: 1.17

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Transcription factors associated with THI2

Gene Symbol Gene ID Gene Info
THI2
S000000444 Transcriptional activator of thiamine biosynthetic genes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THI2YBR240C-0.767.1e-06Click!

Activity profile of THI2 motif

Sorted Z-values of THI2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 23.12
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 20.15 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YER131W 7.37
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YOL127W 7.15
RPL25
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YJL115W 5.95
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YPL250W-A 5.82 Identified by fungal homology and RT-PCR
YLR154C 5.47
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YLR154W-B 4.73 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-A 4.73 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YMR290W-A 4.67 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YDR033W 4.62
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YMR290C 4.62
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YBR092C 4.49
PHO3
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YCR031C 4.29
RPS14A
Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YKR092C 4.29
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YFR054C 4.17 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR031C-A 4.00
RPL2A
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YGR108W 3.96
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YLR150W 3.92
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YNL248C 3.74
RPA49
RNA polymerase I subunit A49
YGL031C 3.41
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YNR018W 3.34
AIM38
Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YOR008C-A 3.26 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YOR143C 3.25
THI80
Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
YKL219W 3.21
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGL077C 3.15
HNM1
Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
YMR123W 3.01
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YGL030W 2.88
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YGR020C 2.87
VMA7
Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YMR246W 2.87
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YPL177C 2.84
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YBR084W 2.82
MIS1
Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
YGL105W 2.78
ARC1
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
YKL110C 2.75
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YOR272W 2.74
YTM1
Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YNL231C 2.70
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YGR040W 2.65
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YMR177W 2.63
MMT1
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YAL038W 2.60
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YBL077W 2.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YLR154W-C 2.59
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YER146W 2.56
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YHR193C 2.55
EGD2
Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
YER130C 2.42 Hypothetical protein
YHR070C-A 2.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W
YHR181W 2.32
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YOR271C 2.32
FSF1
Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YPR074C 2.28
TKL1
Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YBL003C 2.25
HTA2
One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YJL177W 2.22
RPL17B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
YPL043W 2.18
NOP4
Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
YMR116C 2.18
ASC1
G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
YHR007C 2.17
ERG11
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YKL063C 2.16 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YDR133C 2.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YDR509W 2.13 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR508C 2.12
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YIL118W 2.12
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YNL030W 2.08
HHF2
One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YGR078C 2.04
PAC10
Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
YLR262C-A 2.02
TMA7
Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin
YNL247W 2.01 Essential protein of unknown function; may interact with ribosomes, based on co-purification experiments
YMR009W 2.00
ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YML111W 1.99
BUL2
Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1
YDL055C 1.99
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YOL124C 1.96
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YMR037C 1.91
MSN2
Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YML075C 1.88
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YKL096W-A 1.82
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YPR063C 1.81 ER-localized protein of unknown function
YOL130W 1.79
ALR1
Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YCR016W 1.79 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene
YNL290W 1.78
RFC3
Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YLR109W 1.76
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YOR248W 1.72 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YLR257W 1.72 Putative protein of unknown function
YBL002W 1.71
HTB2
One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YGR195W 1.71
SKI6
3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YDR050C 1.70
TPI1
Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
YEL054C 1.70
RPL12A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YJR118C 1.69
ILM1
Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
YHR163W 1.69
SOL3
6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p
YNL301C 1.68
RPL18B
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YNR001W-A 1.66 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YLR437C 1.66 Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YDR041W 1.65
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YKR013W 1.64
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YOR107W 1.58
RGS2
Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YHR094C 1.56
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YDR094W 1.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YBR084C-A 1.55
RPL19A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YML088W 1.54
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YKR093W 1.53
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YOL123W 1.53
HRP1
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YGL201C 1.52
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YIL069C 1.50
RPS24B
Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YBR017C 1.49
KAP104
Transportin, cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression
YDR344C 1.46 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR060W 1.45
ERG25
C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YPR119W 1.43
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YJL222W 1.41
VTH2
Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
YJL167W 1.41
ERG20
Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YDR040C 1.40
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YKR075C 1.40 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YCR087C-A 1.40
LUG1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
YLR108C 1.39 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YHR128W 1.39
FUR1
Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YLL045C 1.37
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YOR009W 1.35
TIR4
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock
YDL211C 1.35 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YBR048W 1.35
RPS11B
Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YPR165W 1.33
RHO1
GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
YLR406C 1.32
RPL31B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YLR287C-A 1.30
RPS30A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein
YHR180W-A 1.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YDR095C 1.30 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR094W-A 1.28
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YGR280C 1.28
PXR1
Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YGL179C 1.25
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YKR012C 1.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YDR418W 1.22
RPL12B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YOR320C 1.22
GNT1
N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus
YCR028C-A 1.21
RIM1
Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
YHL028W 1.21
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YJL080C 1.21
SCP160
Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
YPL112C 1.18
PEX25
Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YOR263C 1.18 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W
YNR028W 1.17
CPR8
Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
YER109C 1.15
FLO8
Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
YPL263C 1.14
KEL3
Cytoplasmic protein of unknown function
YJL168C 1.13
SET2
Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
YJL193W 1.12 Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
YPL014W 1.12 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YLR060W 1.10
FRS1
Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; sequence is evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase (Msf1p), but substrate binding is similar
YNL031C 1.08
HHT2
One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YPL137C 1.07
GIP3
Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
YOL064C 1.07
MET22
Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway
YDR044W 1.06
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YMR230W 1.06
RPS10B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10
YBR283C 1.06
SSH1
Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential
YGR123C 1.05
PPT1
Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YOR362C 1.04
PRE10
Alpha 7 subunit of the 20S proteasome
YJL223C 1.04
PAU1
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YPL254W 1.03
HFI1
Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
YLR413W 1.02 Putative protein of unknown function; YLR413W is not an essential gene
YBR233W-A 1.02
DAD3
Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YML052W 1.01
SUR7
Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YJL222W-A 1.01 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR138C 1.00
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YOR264W 1.00
DSE3
Daughter cell-specific protein, may help establish daughter fate
YHR162W 1.00 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YGR249W 1.00
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YGL097W 1.00
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YGL035C 1.00
MIG1
Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YDL121C 0.99 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDL121C is not an essential protein
YIL164C 0.99
NIT1
Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
YKL152C 0.98
GPM1
Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YBR286W 0.97
APE3
Vacuolar aminopeptidase Y, processed to mature form by Prb1p
YEL051W 0.95
VMA8
Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YPR074W-A 0.93 Hypothetical protein identified by homology
YMR194C-A 0.92 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL240W 0.92
LRG1
Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YNL300W 0.92 Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YKL205W 0.92
LOS1
Nuclear pore protein involved in nuclear export of pre-tRNA
YJL173C 0.91
RFA3
Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YIL011W 0.90
TIR3
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YMR300C 0.90
ADE4
Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
YIL114C 0.89
POR2
Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability
YLR198C 0.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
YML103C 0.88
NUP188
Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
YPR170W-B 0.88 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YOR181W 0.86
LAS17
Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
YGR140W 0.86
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YBR158W 0.86
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YGR130C 0.85 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
YGR124W 0.85
ASN2
Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YLR048W 0.84
RPS0B
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YGL009C 0.83
LEU1
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YKR074W 0.83
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YGL202W 0.83
ARO8
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YLR224W 0.83 F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
YLR009W 0.82
RLP24
Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis
YJR097W 0.81
JJJ3
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YKL065C 0.81
YET1
Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YDR510W 0.80
SMT3
Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YOL161C 0.80
PAU20
Hypothetical protein
YDR502C 0.79
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YGL157W 0.79 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YJR105W 0.79
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YDR023W 0.78
SES1
Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YGR106C 0.78
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YFL015W-A 0.78 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL166C 0.77
FAP7
Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D
YGR180C 0.77
RNR4
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YFL017C 0.77
GNA1
Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
YOR180C 0.76
DCI1
Peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, involved in fatty acid metabolism, contains peroxisome targeting signals at amino and carboxy termini
YFL015C 0.76 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YGR155W 0.75
CYS4
Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YDL047W 0.75
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YOR043W 0.74
WHI2
Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression

Network of associatons between targets according to the STRING database.

First level regulatory network of THI2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 23.1 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
1.4 7.1 GO:2000758 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
1.3 3.9 GO:0043069 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.9 2.8 GO:0035955 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.9 2.7 GO:0043484 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
0.9 2.6 GO:0034225 cellular response to zinc ion starvation(GO:0034224) regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation(GO:0034225) positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422) cellular response to ethanol(GO:0071361) regulation of cell aging(GO:0090342) cellular response to alcohol(GO:0097306) regulation of replicative cell aging(GO:1900062)
0.8 5.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.8 3.2 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.8 3.0 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.7 4.9 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.7 2.0 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.6 10.9 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.6 1.8 GO:0015693 magnesium ion transport(GO:0015693)
0.6 3.0 GO:0032233 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233)
0.6 1.8 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.6 2.8 GO:0046655 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.6 0.6 GO:0031564 transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.6 2.8 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.5 2.5 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.5 7.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.5 1.5 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.5 1.9 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.5 1.4 GO:0016114 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.5 1.4 GO:0006571 tyrosine biosynthetic process(GO:0006571)
0.4 2.2 GO:0010182 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.4 0.4 GO:0010695 regulation of spindle pole body separation(GO:0010695)
0.4 1.7 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.4 2.5 GO:0072337 modified amino acid transport(GO:0072337)
0.4 1.1 GO:2000906 starch metabolic process(GO:0005982) starch catabolic process(GO:0005983) regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter(GO:0035956) positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0035957) positive regulation of multi-organism process(GO:0043902) regulation of starch catabolic process(GO:2000881) positive regulation of starch catabolic process(GO:2000883) regulation of starch metabolic process(GO:2000904) positive regulation of starch metabolic process(GO:2000906)
0.4 1.5 GO:0042938 dipeptide transport(GO:0042938)
0.4 8.5 GO:0006334 nucleosome assembly(GO:0006334)
0.4 1.4 GO:0010138 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.4 3.6 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.3 3.0 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.3 10.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 1.3 GO:1904357 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.3 3.4 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.3 1.2 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.3 0.9 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.3 1.5 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.3 0.9 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.3 2.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.3 1.2 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.3 0.9 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.3 4.2 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.3 1.9 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.3 1.1 GO:0007535 donor selection(GO:0007535)
0.3 2.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.3 0.8 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.3 0.8 GO:0044209 AMP salvage(GO:0044209)
0.3 1.0 GO:0000296 spermine transport(GO:0000296)
0.2 2.0 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.2 1.0 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.2 1.2 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.2 1.9 GO:0006814 sodium ion transport(GO:0006814)
0.2 0.7 GO:0046136 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.2 0.9 GO:0036213 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.2 2.3 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.2 23.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 2.0 GO:0006272 leading strand elongation(GO:0006272)
0.2 0.6 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.2 0.8 GO:0009226 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048) nucleotide-sugar biosynthetic process(GO:0009226)
0.2 6.0 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.2 1.5 GO:0042991 transcription factor import into nucleus(GO:0042991)
0.2 0.7 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.2 0.9 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.2 0.5 GO:0006114 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.2 0.7 GO:0015886 heme transport(GO:0015886)
0.2 0.9 GO:0044070 regulation of anion transport(GO:0044070)
0.2 0.7 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.2 0.8 GO:0009098 leucine biosynthetic process(GO:0009098)
0.2 0.8 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 1.1 GO:0016559 peroxisome fission(GO:0016559)
0.2 0.5 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.2 0.6 GO:0019346 transsulfuration(GO:0019346) homocysteine metabolic process(GO:0050667)
0.2 0.5 GO:0008272 sulfate transport(GO:0008272)
0.1 1.8 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.4 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.1 0.7 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.4 GO:0032006 regulation of TOR signaling(GO:0032006)
0.1 2.4 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 1.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.4 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 0.9 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 1.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.6 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 2.0 GO:0030488 tRNA methylation(GO:0030488)
0.1 1.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.1 0.5 GO:0043007 maintenance of rDNA(GO:0043007)
0.1 0.4 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.4 GO:0032079 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1 0.4 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.1 4.9 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 0.9 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 7.0 GO:0016311 dephosphorylation(GO:0016311)
0.1 0.4 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 1.0 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 0.1 GO:0043407 inactivation of MAPK activity(GO:0000188) negative regulation of MAP kinase activity(GO:0043407)
0.1 0.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.1 2.2 GO:0010038 response to metal ion(GO:0010038)
0.1 0.5 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 1.2 GO:0007120 axial cellular bud site selection(GO:0007120)
0.1 0.9 GO:0000022 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.1 0.1 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 0.3 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.1 0.6 GO:0071039 nuclear polyadenylation-dependent CUT catabolic process(GO:0071039)
0.1 0.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.9 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990)
0.1 0.2 GO:0000304 response to singlet oxygen(GO:0000304) positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.1 0.4 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.1 0.3 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.1 0.1 GO:1901351 regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
0.1 0.2 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.1 0.3 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.6 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.7 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.1 0.9 GO:0009651 response to salt stress(GO:0009651)
0.1 1.6 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 0.6 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.5 GO:0030031 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
0.1 0.3 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.1 0.5 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.1 0.2 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.1 0.2 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 0.3 GO:0001510 RNA methylation(GO:0001510)
0.1 0.8 GO:0016925 protein sumoylation(GO:0016925)
0.1 1.2 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 0.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 1.1 GO:0015918 sterol transport(GO:0015918)
0.1 0.2 GO:0009162 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate biosynthetic process(GO:0046385)
0.1 0.8 GO:0006635 fatty acid beta-oxidation(GO:0006635) fatty acid oxidation(GO:0019395) lipid oxidation(GO:0034440)
0.1 8.8 GO:0006364 rRNA processing(GO:0006364)
0.1 0.4 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.1 0.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 1.4 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.1 0.3 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.1 5.1 GO:0006913 nucleocytoplasmic transport(GO:0006913)
0.1 0.4 GO:0000032 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.1 0.4 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 1.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.5 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 0.6 GO:0051666 actin cortical patch localization(GO:0051666)
0.1 0.2 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.1 0.3 GO:0006273 lagging strand elongation(GO:0006273)
0.1 0.3 GO:0015793 glycerol transport(GO:0015793)
0.1 0.1 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.1 0.2 GO:0008105 asymmetric protein localization(GO:0008105)
0.1 0.1 GO:0072353 cellular age-dependent response to reactive oxygen species(GO:0072353)
0.1 0.6 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.0 0.1 GO:0006687 glycosphingolipid metabolic process(GO:0006687) glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.2 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.0 0.3 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.2 GO:0015883 FAD transport(GO:0015883)
0.0 0.2 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.0 0.2 GO:0015680 intracellular copper ion transport(GO:0015680)
0.0 0.3 GO:0070589 cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.0 0.1 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.1 GO:0006952 immune effector process(GO:0002252) immune system process(GO:0002376) defense response(GO:0006952) response to biotic stimulus(GO:0009607) response to virus(GO:0009615) response to external biotic stimulus(GO:0043207) defense response to virus(GO:0051607) response to other organism(GO:0051707) defense response to other organism(GO:0098542)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 1.0 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.2 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:1900182 endoplasmic reticulum membrane fusion(GO:0016320) ribophagy(GO:0034517) mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230) cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629) nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630) ER-associated misfolded protein catabolic process(GO:0071712) regulation of protein localization to nucleus(GO:1900180) positive regulation of protein localization to nucleus(GO:1900182) positive regulation of cellular protein localization(GO:1903829)
0.0 0.8 GO:0009408 response to heat(GO:0009408)
0.0 0.1 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.4 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.0 0.2 GO:0009749 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.0 0.4 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.2 GO:0006116 NADH oxidation(GO:0006116)
0.0 0.3 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0 0.2 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.2 GO:0016233 telomere capping(GO:0016233)
0.0 0.2 GO:0007323 peptide pheromone maturation(GO:0007323)
0.0 0.8 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.0 GO:1900461 positive regulation of cell growth(GO:0030307) positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter(GO:1900461) positive regulation of pseudohyphal growth(GO:2000222)
0.0 0.2 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.1 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.3 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.0 0.2 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.2 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.2 GO:0006817 phosphate ion transport(GO:0006817)
0.0 0.2 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 0.2 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound biosynthetic process(GO:0042559)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.1 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.1 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.0 0.4 GO:0019319 gluconeogenesis(GO:0006094) hexose biosynthetic process(GO:0019319)
0.0 0.1 GO:0006816 calcium ion transport(GO:0006816)
0.0 0.5 GO:0007015 actin filament organization(GO:0007015)
0.0 0.2 GO:0072503 cellular divalent inorganic cation homeostasis(GO:0072503) divalent inorganic cation homeostasis(GO:0072507)
0.0 0.2 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.5 GO:0008033 tRNA processing(GO:0008033)
0.0 0.1 GO:0032147 activation of protein kinase activity(GO:0032147)
0.0 0.2 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784) positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0 0.3 GO:0009247 glycolipid biosynthetic process(GO:0009247)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.1 4.5 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.9 2.8 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.9 2.7 GO:0070545 PeBoW complex(GO:0070545)
0.8 2.5 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.8 0.8 GO:0030684 preribosome(GO:0030684)
0.7 8.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.6 2.6 GO:0042597 periplasmic space(GO:0042597)
0.5 3.8 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 33.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 2.7 GO:0016272 prefoldin complex(GO:0016272)
0.4 2.9 GO:0005688 U6 snRNP(GO:0005688)
0.4 1.8 GO:0005663 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389) Elg1 RFC-like complex(GO:0031391)
0.4 1.1 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.4 21.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 2.0 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.3 0.6 GO:0030689 Noc complex(GO:0030689)
0.3 0.9 GO:0016363 nuclear matrix(GO:0016363)
0.3 1.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 0.9 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 0.9 GO:0046930 pore complex(GO:0046930)
0.3 1.8 GO:0042555 MCM complex(GO:0042555)
0.3 4.7 GO:0022626 cytosolic ribosome(GO:0022626)
0.3 3.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 0.7 GO:0005787 signal peptidase complex(GO:0005787)
0.2 0.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 0.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 0.9 GO:0031518 CBF3 complex(GO:0031518)
0.2 0.8 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.2 0.6 GO:0070939 Dsl1p complex(GO:0070939)
0.2 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 1.1 GO:0034456 UTP-C complex(GO:0034456)
0.2 2.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.2 0.4 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.2 1.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 0.7 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.2 1.9 GO:0034399 nuclear periphery(GO:0034399)
0.2 0.5 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 0.7 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 1.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 6.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 1.0 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 1.0 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.3 GO:0030428 cell septum(GO:0030428)
0.1 0.4 GO:0070823 HDA1 complex(GO:0070823)
0.1 0.4 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.4 GO:0043529 GET complex(GO:0043529)
0.1 1.0 GO:0016459 myosin complex(GO:0016459)
0.1 0.5 GO:0000938 GARP complex(GO:0000938)
0.1 0.5 GO:0097196 Shu complex(GO:0097196)
0.1 0.6 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 5.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 2.3 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 0.6 GO:0005869 dynactin complex(GO:0005869)
0.1 1.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.4 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.1 1.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.4 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 3.8 GO:0005811 lipid particle(GO:0005811)
0.1 1.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.4 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.3 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 1.3 GO:0005940 septin ring(GO:0005940)
0.1 0.3 GO:0000399 cellular bud neck septin structure(GO:0000399) cleavage apparatus septin structure(GO:0032161)
0.1 0.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 1.3 GO:0016586 RSC complex(GO:0016586)
0.1 0.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.6 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.0 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.5 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.3 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.1 0.5 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.3 GO:0034044 exomer complex(GO:0034044)
0.1 0.4 GO:0051233 spindle midzone(GO:0051233)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.1 1.5 GO:0005844 polysome(GO:0005844)
0.1 0.5 GO:0000142 cellular bud neck contractile ring(GO:0000142)
0.1 0.4 GO:0000346 transcription export complex(GO:0000346)
0.1 0.1 GO:0030904 retromer complex(GO:0030904)
0.1 0.6 GO:0031985 Golgi cisterna(GO:0031985)
0.1 7.9 GO:0005730 nucleolus(GO:0005730)
0.0 0.2 GO:0033309 SBF transcription complex(GO:0033309)
0.0 1.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 1.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.2 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852) multi-eIF complex(GO:0043614)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 4.2 GO:0005933 cellular bud(GO:0005933)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.3 GO:0000243 commitment complex(GO:0000243)
0.0 0.8 GO:0015935 small ribosomal subunit(GO:0015935)
0.0 0.2 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.2 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.4 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 20.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.4 5.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.0 5.7 GO:0003993 acid phosphatase activity(GO:0003993)
0.9 2.8 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.7 2.9 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.7 2.1 GO:0070568 guanylyltransferase activity(GO:0070568)
0.7 2.0 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.6 3.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.6 1.8 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.6 2.8 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.6 2.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.5 3.8 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.5 3.2 GO:0070300 phosphatidic acid binding(GO:0070300)
0.5 2.7 GO:0004707 MAP kinase activity(GO:0004707)
0.5 5.2 GO:0005216 ion channel activity(GO:0005216)
0.5 2.0 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.5 3.3 GO:0016778 diphosphotransferase activity(GO:0016778)
0.4 2.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.4 1.7 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.4 1.3 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.4 2.3 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.4 1.5 GO:0009378 four-way junction helicase activity(GO:0009378)
0.4 1.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.4 2.9 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.3 1.0 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.3 3.1 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.3 1.2 GO:0008252 nucleotidase activity(GO:0008252)
0.3 1.8 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 13.4 GO:0019843 rRNA binding(GO:0019843)
0.3 3.7 GO:0001054 RNA polymerase I activity(GO:0001054)
0.3 1.1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.3 2.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.3 1.6 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.3 0.8 GO:0004017 adenylate kinase activity(GO:0004017)
0.3 1.5 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.3 7.8 GO:0046982 protein heterodimerization activity(GO:0046982)
0.3 1.0 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.2 1.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 0.7 GO:0004100 chitin synthase activity(GO:0004100)
0.2 0.9 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 0.8 GO:0019206 nucleoside kinase activity(GO:0019206)
0.2 4.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.2 0.8 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 34.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 0.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 1.3 GO:1901681 sulfur compound binding(GO:1901681)
0.2 0.6 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 0.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 1.5 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.2 0.7 GO:0005471 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.2 0.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.2 1.4 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 5.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.2 6.5 GO:0042393 histone binding(GO:0042393)
0.2 0.8 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.2 3.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 1.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 0.5 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.2 1.4 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.2 1.2 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.2 0.5 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.1 0.7 GO:0000146 microfilament motor activity(GO:0000146)
0.1 1.1 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 0.4 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 1.6 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.5 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 4.1 GO:0015631 tubulin binding(GO:0015631)
0.1 0.4 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.1 0.6 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 0.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.9 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 2.0 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.3 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 0.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 2.4 GO:0019901 protein kinase binding(GO:0019901)
0.1 0.3 GO:0009922 fatty acid elongase activity(GO:0009922)
0.1 1.1 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.5 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 1.4 GO:0004659 prenyltransferase activity(GO:0004659)
0.1 0.3 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 1.2 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.1 2.0 GO:0005048 signal sequence binding(GO:0005048)
0.1 1.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 1.2 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.4 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.3 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.1 3.6 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.0 GO:0030674 protein binding, bridging(GO:0030674)
0.1 1.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.2 GO:0019202 amino acid kinase activity(GO:0019202)
0.1 0.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.1 2.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.0 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.4 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.3 GO:0019238 cyclohydrolase activity(GO:0019238)
0.1 0.7 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.2 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.1 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.7 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.2 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1 0.3 GO:0017108 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.1 0.2 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.2 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.0 0.1 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 2.2 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 0.2 GO:0017022 myosin binding(GO:0017022)
0.0 3.2 GO:0003682 chromatin binding(GO:0003682)
0.0 0.6 GO:0003774 motor activity(GO:0003774)
0.0 0.3 GO:0017069 snRNA binding(GO:0017069)
0.0 0.7 GO:0005507 copper ion binding(GO:0005507)
0.0 3.2 GO:0005525 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.0 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 1.2 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.6 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 0.6 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.3 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.5 GO:0043566 structure-specific DNA binding(GO:0043566)
0.0 0.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.0 GO:0051213 dioxygenase activity(GO:0051213)
0.0 0.3 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.2 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) thiol oxidase activity(GO:0016972)
0.0 0.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0019239 deaminase activity(GO:0019239)
0.0 0.2 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.2 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0 5.5 GO:0003723 RNA binding(GO:0003723)
0.0 0.7 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 0.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.1 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.0 0.4 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.4 GO:0008047 enzyme activator activity(GO:0008047)
0.0 0.8 GO:0001159 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.1 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 0.1 GO:0005319 lipid transporter activity(GO:0005319)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.3 1.7 PID FGF PATHWAY FGF signaling pathway
0.2 2.0 PID ATR PATHWAY ATR signaling pathway
0.1 0.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 0.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 0.2 PID E2F PATHWAY E2F transcription factor network
0.0 0.1 PID MYC PATHWAY C-MYC pathway
0.0 0.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.5 2.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.4 1.8 REACTOME NUCLEOTIDE EXCISION REPAIR Genes involved in Nucleotide Excision Repair
0.4 2.9 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.3 0.9 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.3 0.9 REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT Genes involved in SLC-mediated transmembrane transport
0.3 2.0 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.3 1.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 3.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 0.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.0 0.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.0 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.1 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.0 0.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase